| Year |
Citation |
Score |
| 2022 |
Joslyn LR, Flynn JL, Kirschner DE, Linderman JJ. Concomitant immunity to M. tuberculosis infection. Scientific Reports. 12: 20731. PMID 36456599 DOI: 10.1038/s41598-022-24516-8 |
0.355 |
|
| 2022 |
Grant NL, Maiello P, Klein E, Lin PL, Borish HJ, Tomko J, Frye LJ, White AG, Kirschner DE, Mattila JT, Flynn JL. T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques. Cell Reports. 39: 110826. PMID 35584684 DOI: 10.1016/j.celrep.2022.110826 |
0.313 |
|
| 2022 |
Joslyn LR, Linderman JJ, Kirschner DE. A virtual host model of Mycobacterium tuberculosis infection identifies early immune events as predictive of infection outcomes. Journal of Theoretical Biology. 539: 111042. PMID 35114195 DOI: 10.1016/j.jtbi.2022.111042 |
0.333 |
|
| 2020 |
Millar JA, Butler JR, Evans S, Mattila JT, Linderman JJ, Flynn JL, Kirschner DE. Spatial Organization and Recruitment of Non-Specific T Cells May Limit T Cell-Macrophage Interactions Within Granulomas. Frontiers in Immunology. 11: 613638. PMID 33552077 DOI: 10.3389/fimmu.2020.613638 |
0.385 |
|
| 2020 |
Renardy M, Kirschner DE. Predicting the second wave of COVID-19 in Washtenaw County, MI. Medrxiv : the Preprint Server For Health Sciences. PMID 32676613 DOI: 10.1016/J.Jtbi.2020.110461 |
0.343 |
|
| 2020 |
Renardy M, Kirschner DE. A Framework for Network-Based Epidemiological Modeling of Tuberculosis Dynamics Using Synthetic Datasets. Bulletin of Mathematical Biology. 82: 78. PMID 32535697 DOI: 10.1007/S11538-020-00752-9 |
0.391 |
|
| 2020 |
Wessler T, Joslyn LR, Borish HJ, Gideon HP, Flynn JL, Kirschner DE, Linderman JJ. A computational model tracks whole-lung Mycobacterium tuberculosis infection and predicts factors that inhibit dissemination. Plos Computational Biology. 16: e1007280. PMID 32433646 DOI: 10.1371/Journal.Pcbi.1007280 |
0.43 |
|
| 2020 |
Cicchese JM, Dartois V, Kirschner DE, Linderman JJ. Both Pharmacokinetic Variability and Granuloma Heterogeneity Impact the Ability of the First-Line Antibiotics to Sterilize Tuberculosis Granulomas. Frontiers in Pharmacology. 11: 333. PMID 32265707 DOI: 10.3389/Fphar.2020.00333 |
0.321 |
|
| 2019 |
Wong EA, Evans S, Kraus CR, Engelman KD, Maiello P, Flores WJ, Cadena AM, Klein E, Thomas K, White AG, Causgrove C, Stein B, Tomko J, Mattila JT, Gideon H, ... ... Kirschner DE, et al. IL-10 Impairs Local Immune Response in Lung Granulomas and Lymph Nodes during Early Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 31862711 DOI: 10.4049/Jimmunol.1901211 |
0.347 |
|
| 2019 |
Sarathy J, Blanc L, Alvarez-Cabrera N, O'Brien P, Dias-Freedman I, Mina M, Zimmerman M, Kaya F, Liang HH, Prideaux B, Dietzold J, Salgame P, Savic R, Linderman J, Kirschner D, et al. Fluoroquinolone efficacy against tuberculosis is driven by penetration into lesions and activity against resident bacterial populations. Antimicrobial Agents and Chemotherapy. PMID 30803965 DOI: 10.1128/Aac.02516-18 |
0.312 |
|
| 2018 |
Marino S, Hult C, Wolberg P, Linderman JJ, Kirschner DE. The Role of Dimensionality in Understanding Granuloma Formation. Computation (Basel, Switzerland). 6. PMID 31258937 DOI: 10.3390/Computation6040058 |
0.373 |
|
| 2018 |
Joslyn LR, Pienaar E, DiFazio RM, Suliman S, Kagina BM, Flynn JL, Scriba TJ, Linderman JJ, Kirschner DE. Integrating Non-human Primate, Human, and Mathematical Studies to Determine the Influence of BCG Timing on H56 Vaccine Outcomes. Frontiers in Microbiology. 9: 1734. PMID 30177914 DOI: 10.3389/Fmicb.2018.01734 |
0.303 |
|
| 2018 |
Cicchese JM, Evans S, Hult C, Joslyn LR, Wessler T, Millar JA, Marino S, Cilfone NA, Mattila JT, Linderman JJ, Kirschner DE. Dynamic balance of pro- and anti-inflammatory signals controls disease and limits pathology. Immunological Reviews. 285: 147-167. PMID 30129209 DOI: 10.1111/Imr.12671 |
0.42 |
|
| 2018 |
Wong EA, Joslyn L, Grant NL, Klein E, Lin PL, Kirschner DE, Flynn JL. Low levels of T cell exhaustion in tuberculous lung granulomas. Infection and Immunity. PMID 29891540 DOI: 10.1128/Iai.00426-18 |
0.447 |
|
| 2017 |
Kirschner D, Pienaar E, Marino S, Linderman JJ. A review of computational and mathematical modeling contributions to our understanding of Mycobacterium tuberculosis within-host infection and treatment. Current Opinion in Systems Biology. 3: 170-185. PMID 30714019 DOI: 10.1016/J.Coisb.2017.05.014 |
0.437 |
|
| 2017 |
Warsinske HC, Pienaar E, Linderman JJ, Mattila JT, Kirschner DE. Deletion of TGF-β1 Increases Bacterial Clearance by Cytotoxic T Cells in a Tuberculosis Granuloma Model. Frontiers in Immunology. 8: 1843. PMID 29326718 DOI: 10.3389/Fimmu.2017.01843 |
0.414 |
|
| 2017 |
Pienaar E, Sarathy J, Prideaux B, Dietzold J, Dartois V, Kirschner DE, Linderman JJ. Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach. Plos Computational Biology. 13: e1005650. PMID 28817561 DOI: 10.1371/Journal.Pcbi.1005650 |
0.337 |
|
| 2017 |
Warsinske HC, DiFazio RM, Linderman JJ, Flynn JL, Kirschner DE. Identifying mechanisms driving formation of granuloma-associated fibrosis during Mycobacterium tuberculosis infection. Journal of Theoretical Biology. PMID 28642013 DOI: 10.1016/J.Jtbi.2017.06.017 |
0.404 |
|
| 2016 |
Marino S, Kirschner DE. A Multi-Compartment Hybrid Computational Model Predicts Key Roles for Dendritic Cells in Tuberculosis Infection. Computation (Basel, Switzerland). 4. PMID 28989808 DOI: 10.3390/Computation4040039 |
0.434 |
|
| 2016 |
Warsinske HC, Wheaton AK, Kim KK, Linderman JJ, Moore BB, Kirschner DE. Computational Modeling Predicts Simultaneous Targeting of Fibroblasts and Epithelial Cells Is Necessary for Treatment of Pulmonary Fibrosis. Frontiers in Pharmacology. 7: 183. PMID 27445819 DOI: 10.3389/Fphar.2016.00183 |
0.3 |
|
| 2016 |
Marino S, Gideon HP, Gong C, Mankad S, McCrone JT, Lin PL, Linderman JJ, Flynn JL, Kirschner DE. Computational and Empirical Studies Predict Mycobacterium tuberculosis-Specific T Cells as a Biomarker for Infection Outcome. Plos Computational Biology. 12: e1004804. PMID 27065304 DOI: 10.1371/Journal.Pcbi.1004804 |
0.433 |
|
| 2016 |
Pienaar E, Matern WM, Linderman JJ, Bader JS, Kirschner DE. Multi-scale model of Mycobacterium tuberculosis infection maps metabolite and gene perturbations to granuloma sterilization predictions. Infection and Immunity. PMID 26975995 DOI: 10.1128/Iai.01438-15 |
0.39 |
|
| 2015 |
Linderman JJ, Kirschner DE. In silico models of M. tuberculosis infection provide a route to new therapies. Drug Discovery Today. Disease Models. 15: 37-41. PMID 26904139 DOI: 10.1016/J.Ddmod.2014.02.006 |
0.34 |
|
| 2015 |
Ziraldo C, Gong C, Kirschner DE, Linderman JJ. Strategic Priming with Multiple Antigens can Yield Memory Cell Phenotypes Optimized for Infection with Mycobacterium tuberculosis: A Computational Study. Frontiers in Microbiology. 6: 1477. PMID 26779136 DOI: 10.3389/Fmicb.2015.01477 |
0.323 |
|
| 2015 |
Pienaar E, Dartois V, Linderman JJ, Kirschner DE. In silico evaluation and exploration of antibiotic tuberculosis treatment regimens. Bmc Systems Biology. 9: 79. PMID 26578235 DOI: 10.1186/S12918-015-0221-8 |
0.351 |
|
| 2015 |
Cilfone NA, Kirschner DE, Linderman JJ. Strategies for efficient numerical implementation of hybrid multi-scale agent-based models to describe biological systems. Cellular and Molecular Bioengineering. 8: 119-136. PMID 26366228 DOI: 10.1007/S12195-014-0363-6 |
0.314 |
|
| 2015 |
Guzzetta G, Ajelli M, Yang Z, Mukasa LN, Patil N, Bates JH, Kirschner DE, Merler S. Effectiveness of contact investigations for tuberculosis control in Arkansas. Journal of Theoretical Biology. 380: 238-246. PMID 26051196 DOI: 10.1016/J.Jtbi.2015.05.031 |
0.306 |
|
| 2015 |
Linderman JJ, Cilfone NA, Pienaar E, Gong C, Kirschner DE. A multi-scale approach to designing therapeutics for tuberculosis. Integrative Biology : Quantitative Biosciences From Nano to Macro. 7: 591-609. PMID 25924949 DOI: 10.1039/C4Ib00295D |
0.36 |
|
| 2015 |
Gong C, Linderman JJ, Kirschner D. A population model capturing dynamics of tuberculosis granulomas predicts host infection outcomes. Mathematical Biosciences and Engineering : Mbe. 12: 625-42. PMID 25811559 DOI: 10.3934/Mbe.2015.12.625 |
0.445 |
|
| 2015 |
Gideon HP, Phuah J, Myers AJ, Bryson BD, Rodgers MA, Coleman MT, Maiello P, Rutledge T, Marino S, Fortune SM, Kirschner DE, Lin PL, Flynn JL. Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization. Plos Pathogens. 11: e1004603. PMID 25611466 DOI: 10.1371/Journal.Ppat.1004603 |
0.409 |
|
| 2015 |
Cilfone NA, Ford CB, Marino S, Mattila JT, Gideon HP, Flynn JL, Kirschner DE, Linderman JJ. Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity-mediated antimicrobial responses with caseation during mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 194: 664-77. PMID 25512604 DOI: 10.4049/Jimmunol.1400734 |
0.343 |
|
| 2015 |
Pienaar E, Cilfone NA, Lin PL, Dartois V, Mattila JT, Butler JR, Flynn JL, Kirschner DE, Linderman JJ. A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment. Journal of Theoretical Biology. 367: 166-79. PMID 25497475 DOI: 10.1016/J.Jtbi.2014.11.021 |
0.419 |
|
| 2015 |
Marino S, Cilfone NA, Mattila JT, Linderman JJ, Flynn JL, Kirschner DE. Macrophage polarization drives granuloma outcome during Mycobacterium tuberculosis infection. Infection and Immunity. 83: 324-38. PMID 25368116 DOI: 10.1128/Iai.02494-14 |
0.374 |
|
| 2014 |
Davis GS, Marino S, Marrs CF, Gilsdorf JR, Dawid S, Kirschner DE. Phase variation and host immunity against high molecular weight (HMW) adhesins shape population dynamics of nontypeable Haemophilus influenzae within human hosts. Journal of Theoretical Biology. 355: 208-18. PMID 24747580 DOI: 10.1016/J.Jtbi.2014.04.010 |
0.349 |
|
| 2014 |
Gong C, Linderman JJ, Kirschner D. Harnessing the heterogeneity of T cell differentiation fate to fine-tune generation of effector and memory T cells. Frontiers in Immunology. 5: 57. PMID 24600448 DOI: 10.3389/Fimmu.2014.00057 |
0.417 |
|
| 2014 |
Cilfone NA, Pienaar E, Kirschner DE, Linderman JJ. Computational Modeling of Granuloma Formation in Tuberculosis Yields Insights into both Infection and Treatment Biophysical Journal. 106: 644a. DOI: 10.1016/J.Bpj.2013.11.3565 |
0.426 |
|
| 2013 |
Cilfone NA, Perry CR, Kirschner DE, Linderman JJ. Multi-scale modeling predicts a balance of tumor necrosis factor-α and interleukin-10 controls the granuloma environment during Mycobacterium tuberculosis infection. Plos One. 8: e68680. PMID 23869227 DOI: 10.1371/Journal.Pone.0068680 |
0.37 |
|
| 2013 |
Gong C, Mattila JT, Miller M, Flynn JL, Linderman JJ, Kirschner D. Predicting lymph node output efficiency using systems biology. Journal of Theoretical Biology. 335: 169-84. PMID 23816876 DOI: 10.1016/J.Jtbi.2013.06.016 |
0.409 |
|
| 2013 |
Mattila JT, Ojo OO, Kepka-Lenhart D, Marino S, Kim JH, Eum SY, Via LE, Barry CE, Klein E, Kirschner DE, Morris SM, Lin PL, Flynn JL. Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms. Journal of Immunology (Baltimore, Md. : 1950). 191: 773-84. PMID 23749634 DOI: 10.4049/Jimmunol.1300113 |
0.316 |
|
| 2013 |
Guzzetta G, Kirschner D. The Roles of Immune Memory and Aging in Protective Immunity and Endogenous Reactivation of Tuberculosis Plos One. 8. PMID 23580062 DOI: 10.1371/Journal.Pone.0060425 |
0.417 |
|
| 2013 |
Myers AJ, Marino S, Kirschner DE, Flynn JL. Inoculation dose of Mycobacterium tuberculosis does not influence priming of T cell responses in lymph nodes. Journal of Immunology (Baltimore, Md. : 1950). 190: 4707-16. PMID 23547119 DOI: 10.4049/Jimmunol.1203465 |
0.35 |
|
| 2013 |
El-Kebir M, van der Kuip M, van Furth AM, Kirschner DE. Computational modeling of tuberculous meningitis reveals an important role for tumor necrosis factor-α. Journal of Theoretical Biology. 328: 43-53. PMID 23542051 DOI: 10.1016/J.Jtbi.2013.03.008 |
0.381 |
|
| 2013 |
Repasy T, Lee J, Marino S, Martinez N, Kirschner DE, Hendricks G, Baker S, Wilson AA, Kotton DN, Kornfeld H. Intracellular bacillary burden reflects a burst size for Mycobacterium tuberculosis in vivo. Plos Pathogens. 9: e1003190. PMID 23436998 DOI: 10.1371/Journal.Ppat.1003190 |
0.41 |
|
| 2013 |
Qin S, Junecko BA, Lucero CM, Klamar CR, Trichel AM, Murphey-Corb MA, Tarwater PM, Kirschner DE, Reinhart TA. Simian immunodeficiency virus infection potently modulates chemokine networks and immune environments in hilar lymph nodes of cynomolgus macaques. Journal of Acquired Immune Deficiency Syndromes (1999). 63: 428-37. PMID 23429503 DOI: 10.1097/Qai.0B013E31828Ac85F |
0.416 |
|
| 2012 |
Fallahi-Sichani M, Kirschner DE, Linderman JJ. NF-κB Signaling Dynamics Play a Key Role in Infection Control in Tuberculosis. Frontiers in Physiology. 3: 170. PMID 22685435 DOI: 10.3389/Fphys.2012.00170 |
0.402 |
|
| 2011 |
Guzzetta G, Ajelli M, Yang Z, Merler S, Furlanello C, Kirschner D. Modeling socio-demography to capture tuberculosis transmission dynamics in a low burden setting. Journal of Theoretical Biology. 289: 197-205. PMID 21906603 DOI: 10.1016/J.Jtbi.2011.08.032 |
0.349 |
|
| 2011 |
Spagnuolo AM, Dirita V, Kirschner D. A model for Vibrio cholerae colonization of the human intestine. Journal of Theoretical Biology. 289: 247-58. PMID 21903104 DOI: 10.1016/J.Jtbi.2011.08.028 |
0.33 |
|
| 2011 |
Mirsky HP, Miller MJ, Linderman JJ, Kirschner DE. Systems biology approaches for understanding cellular mechanisms of immunity in lymph nodes during infection. Journal of Theoretical Biology. 287: 160-70. PMID 21798267 DOI: 10.1016/J.Jtbi.2011.06.037 |
0.427 |
|
| 2011 |
Marino S, El-Kebir M, Kirschner D. A hybrid multi-compartment model of granuloma formation and T cell priming in tuberculosis. Journal of Theoretical Biology. 280: 50-62. PMID 21443879 DOI: 10.1016/J.Jtbi.2011.03.022 |
0.476 |
|
| 2011 |
Fallahi-Sichani M, El-Kebir M, Marino S, Kirschner DE, Linderman JJ. Multiscale computational modeling reveals a critical role for TNF-α receptor 1 dynamics in tuberculosis granuloma formation. Journal of Immunology (Baltimore, Md. : 1950). 186: 3472-83. PMID 21321109 DOI: 10.4049/Jimmunol.1003299 |
0.435 |
|
| 2011 |
Marino S, Linderman JJ, Kirschner DE. A multifaceted approach to modeling the immune response in tuberculosis. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 3: 479-89. PMID 21197656 DOI: 10.1002/Wsbm.131 |
0.428 |
|
| 2010 |
Qin S, Fallert Junecko BA, Trichel AM, Tarwater PM, Murphey-Corb MA, Kirschner DE, Reinhart TA. Simian immunodeficiency virus infection alters chemokine networks in lung tissues of cynomolgus macaques: association with Pneumocystis carinii infection. The American Journal of Pathology. 177: 1274-85. PMID 20671263 DOI: 10.2353/Ajpath.2010.091288 |
0.402 |
|
| 2010 |
Kirschner DE, Young D, Flynn JL. Tuberculosis: global approaches to a global disease. Current Opinion in Biotechnology. 21: 524-31. PMID 20637596 DOI: 10.1016/J.Copbio.2010.06.002 |
0.384 |
|
| 2010 |
Marino S, Myers A, Flynn JL, Kirschner DE. TNF and IL-10 are major factors in modulation of the phagocytic cell environment in lung and lymph node in tuberculosis: a next-generation two-compartmental model. Journal of Theoretical Biology. 265: 586-98. PMID 20510249 DOI: 10.1016/J.Jtbi.2010.05.012 |
0.37 |
|
| 2010 |
Fallahi-Sichani M, Schaller MA, Kirschner DE, Kunkel SL, Linderman JJ. Identification of key processes that control tumor necrosis factor availability in a tuberculosis granuloma. Plos Computational Biology. 6: e1000778. PMID 20463877 DOI: 10.1371/Journal.Pcbi.1000778 |
0.389 |
|
| 2010 |
Linderman JJ, Riggs T, Pande M, Miller M, Marino S, Kirschner DE. Characterizing the dynamics of CD4+ T cell priming within a lymph node. Journal of Immunology (Baltimore, Md. : 1950). 184: 2873-85. PMID 20154206 DOI: 10.4049/Jimmunol.0903117 |
0.389 |
|
| 2009 |
Kirschner D, Tsygvintsev A. On the global dynamics of a model for tumor immunotherapy. Mathematical Biosciences and Engineering : Mbe. 6: 573-83. PMID 19566127 DOI: 10.3934/Mbe.2009.6.573 |
0.315 |
|
| 2009 |
Ray JC, Flynn JL, Kirschner DE. Synergy between individual TNF-dependent functions determines granuloma performance for controlling Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 182: 3706-17. PMID 19265149 DOI: 10.4049/Jimmunol.0802297 |
0.674 |
|
| 2009 |
Kirschner DE, Linderman JJ. Mathematical and computational approaches can complement experimental studies of host-pathogen interactions. Cellular Microbiology. 11: 531-9. PMID 19134115 DOI: 10.1111/J.1462-5822.2008.01281.X |
0.338 |
|
| 2008 |
Hogue IB, Bajaria SH, Fallert BA, Qin S, Reinhart TA, Kirschner DE. The dual role of dendritic cells in the immune response to human immunodeficiency virus type 1 infection. The Journal of General Virology. 89: 2228-39. PMID 18753232 DOI: 10.1099/Vir.0.83600-0 |
0.785 |
|
| 2008 |
Young D, Stark J, Kirschner D. Systems biology of persistent infection: tuberculosis as a case study. Nature Reviews Microbiology. 6: 520-528. PMID 18536727 DOI: 10.1038/Nrmicro1919 |
0.366 |
|
| 2008 |
Chang ST, Linderman JJ, Kirschner DE. Effect of multiple genetic polymorphisms on antigen presentation and susceptibility to Mycobacterium tuberculosis infection. Infection and Immunity. 76: 3221-32. PMID 18443099 DOI: 10.1128/Iai.01677-07 |
0.308 |
|
| 2008 |
Qin S, Sui Y, Soloff AC, Junecko BA, Kirschner DE, Murphey-Corb MA, Watkins SC, Tarwater PM, Pease JE, Barratt-Boyes SM, Reinhart TA. Chemokine and cytokine mediated loss of regulatory T cells in lymph nodes during pathogenic simian immunodeficiency virus infection. Journal of Immunology (Baltimore, Md. : 1950). 180: 5530-6. PMID 18390737 DOI: 10.4049/Jimmunol.180.8.5530 |
0.437 |
|
| 2008 |
Ray JC, Wang J, Chan J, Kirschner DE. The timing of TNF and IFN-gamma signaling affects macrophage activation strategies during Mycobacterium tuberculosis infection. Journal of Theoretical Biology. 252: 24-38. PMID 18321531 DOI: 10.1016/J.Jtbi.2008.01.010 |
0.662 |
|
| 2008 |
Chakravarty SD, Zhu G, Tsai MC, Mohan VP, Marino S, Kirschner DE, Huang L, Flynn J, Chan J. Tumor necrosis factor blockade in chronic murine tuberculosis enhances granulomatous inflammation and disorganizes granulomas in the lungs. Infection and Immunity. 76: 916-26. PMID 18212087 DOI: 10.1128/Iai.01011-07 |
0.366 |
|
| 2008 |
Riggs T, Walts A, Perry N, Bickle L, Lynch JN, Myers A, Flynn J, Linderman JJ, Miller MJ, Kirschner DE. A comparison of random vs. chemotaxis-driven contacts of T cells with dendritic cells during repertoire scanning. Journal of Theoretical Biology. 250: 732-51. PMID 18068193 DOI: 10.1016/J.Jtbi.2007.10.015 |
0.377 |
|
| 2008 |
Fallert BA, Poveda S, Schaefer TM, Pfeifer ME, Sanghavi SK, Watkins SC, Murphey-Corb MA, Tarwater PM, Kirschner DE, Reinhart TA. Virologic and immunologic events in hilar lymph nodes during simian immunodeficiency virus infection: development of polarized inflammation. Journal of Acquired Immune Deficiency Syndromes (1999). 47: 16-26. PMID 17971706 DOI: 10.1097/QAI.0b013e31815cea8b |
0.325 |
|
| 2008 |
Bauer AL, Hogue IB, Marino S, Kirschner DE. The Effects of HIV-1 Infection on Latent Tuberculosis Mathematical Modelling of Natural Phenomena. 3: 229-266. DOI: 10.1051/Mmnp:2008051 |
0.496 |
|
| 2007 |
Marino S, Sud D, Plessner H, Lin PL, Chan J, Flynn JL, Kirschner DE. Differences in reactivation of tuberculosis induced from anti-TNF treatments are based on bioavailability in granulomatous tissue. Plos Computational Biology. 3: 1909-24. PMID 17953477 DOI: 10.1371/Journal.Pcbi.0030194 |
0.385 |
|
| 2007 |
Blaser MJ, Kirschner D. The equilibria that allow bacterial persistence in human hosts Nature. 449: 843-849. PMID 17943121 DOI: 10.1038/Nature06198 |
0.3 |
|
| 2007 |
Marino S, Beretta E, Kirschner DE. The role of delays in innate and adaptive immunity to intracellular bacterial infection. Mathematical Biosciences and Engineering : Mbe. 4: 261-88. PMID 17658927 DOI: 10.3934/Mbe.2007.4.261 |
0.401 |
|
| 2007 |
Plessner HL, Lin PL, Kohno T, Louie JS, Kirschner D, Chan J, Flynn JL. Neutralization of tumor necrosis factor (TNF) by antibody but not TNF receptor fusion molecule exacerbates chronic murine tuberculosis. The Journal of Infectious Diseases. 195: 1643-50. PMID 17471434 DOI: 10.1086/517519 |
0.328 |
|
| 2007 |
Kirschner DE, Chang ST, Riggs TW, Perry N, Linderman JJ. Toward a multiscale model of antigen presentation in immunity. Immunological Reviews. 216: 93-118. PMID 17367337 DOI: 10.1111/J.1600-065X.2007.00490.X |
0.335 |
|
| 2006 |
Morel PA, Ta'asan S, Morel BF, Kirschner DE, Flynn JL. New insights into mathematical modeling of the immune system. Immunologic Research. 36: 157-65. PMID 17337776 DOI: 10.1385/Ir:36:1:157 |
0.334 |
|
| 2006 |
Schaefer TM, Fuller CL, Basu S, Fallert BA, Poveda SL, Sanghavi SK, Choi YK, Kirschner DE, Feingold E, Reinhart TA. Increased expression of interferon-inducible genes in macaque lung tissues during simian immunodeficiency virus infection. Microbes and Infection / Institut Pasteur. 8: 1839-50. PMID 16822691 DOI: 10.1016/J.Micinf.2006.02.022 |
0.407 |
|
| 2006 |
Sud D, Bigbee C, Flynn JL, Kirschner DE. Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection. Journal of Immunology (Baltimore, Md. : 1950). 176: 4296-314. PMID 16547267 DOI: 10.4049/Jimmunol.176.7.4296 |
0.453 |
|
| 2006 |
Ray JC, Kirschner DE. Requirement for multiple activation signals by anti-inflammatory feedback in macrophages. Journal of Theoretical Biology. 241: 276-94. PMID 16460764 DOI: 10.1016/J.Jtbi.2005.11.037 |
0.594 |
|
| 2006 |
Sud D, Bigbee C, Flynn JL, Kirschner DE. Contribution of CD8+ T cells to control of Mycobacterium tuberculosis infection. The Journal of Immunology. 177: 5747.2-5747. DOI: 10.4049/jimmunol.177.8.5747-a |
0.328 |
|
| 2005 |
Ganguli S, Gammack D, Kirschner DE. A metapopulation model of granuloma formation in the lung during infection with mycobacterium tuberculosis. Mathematical Biosciences and Engineering : Mbe. 2: 535-60. PMID 20369939 DOI: 10.3934/Mbe.2005.2.535 |
0.423 |
|
| 2005 |
Kirschner D, Marino S. Mycobacterium tuberculosis as viewed through a computer. Trends in Microbiology. 13: 206-11. PMID 15866037 DOI: 10.1016/J.Tim.2005.03.005 |
0.425 |
|
| 2005 |
Bajaria SH, Kirschner DE. CTL action during HIV-1 is determined VIA interactions with multiple cell types Deterministic and Stochastic Models of Aids Epidemics and Hiv Infections With Intervention. 219-254. DOI: 10.1142/9789812569264_0010 |
0.781 |
|
| 2005 |
Gammack D, Ganguli S, Marino S, Segovia-Juarez J, Kirschner DE. Understanding the Immune Response in Tuberculosis Using Different Mathematical Models and Biological Scales Multiscale Modeling & Simulation. 3: 312-345. DOI: 10.1137/040603127 |
0.42 |
|
| 2005 |
Lin PL, Kirschner D, Flynn JL. Modeling pathogen and host: in vitro, in vivo and in silico models of latent Mycobacterium tuberculosis infection Drug Discovery Today: Disease Models. 2: 149-154. DOI: 10.1016/J.Ddmod.2005.05.019 |
0.481 |
|
| 2004 |
Singer BH, Kirschner DE. Influence of backward bifurcation on interpretation of r(0) in a model of epidemic tuberculosis with reinfection. Mathematical Biosciences and Engineering : Mbe. 1: 81-93. PMID 20369961 DOI: 10.3934/Mbe.2004.1.81 |
0.41 |
|
| 2004 |
Segovia-Juarez JL, Ganguli S, Kirschner D. Identifying control mechanisms of granuloma formation during M. tuberculosis infection using an agent-based model. Journal of Theoretical Biology. 231: 357-76. PMID 15501468 DOI: 10.1016/J.Jtbi.2004.06.031 |
0.487 |
|
| 2004 |
Bajaria SH, Webb G, Kirschner DE. Predicting differential responses to structured treatment interruptions during HAART. Bulletin of Mathematical Biology. 66: 1093-118. PMID 15294419 DOI: 10.1016/J.Bulm.2003.11.003 |
0.762 |
|
| 2004 |
Marino S, Pawar S, Fuller CL, Reinhart TA, Flynn JL, Kirschner DE. Dendritic cell trafficking and antigen presentation in the human immune response to Mycobacterium tuberculosis. Journal of Immunology (Baltimore, Md. : 1950). 173: 494-506. PMID 15210810 DOI: 10.4049/Jimmunol.173.1.494 |
0.468 |
|
| 2004 |
Ye P, Kazanjian P, Kunkel SL, Kirschner DE. Lack of good correlation of serum CC-chemokine levels with human immunodeficiency virus-1 disease stage and response to treatment. The Journal of Laboratory and Clinical Medicine. 143: 310-9. PMID 15122175 DOI: 10.1016/J.Lab.2004.01.012 |
0.516 |
|
| 2004 |
Ye P, Kirschner DE, Kourtis AP. The thymus during HIV disease: role in pathogenesis and in immune recovery. Current Hiv Research. 2: 177-83. PMID 15078181 DOI: 10.2174/1570162043484898 |
0.568 |
|
| 2004 |
Joseph IM, Kirschner D. A model for the study of Helicobacter pylori interaction with human gastric acid secretion. Journal of Theoretical Biology. 228: 55-80. PMID 15064083 DOI: 10.1016/J.Jtbi.2003.12.004 |
0.762 |
|
| 2004 |
Marino S, Kirschner DE. The human immune response to Mycobacterium tuberculosis in lung and lymph node. Journal of Theoretical Biology. 227: 463-86. PMID 15038983 DOI: 10.1016/J.Jtbi.2003.11.023 |
0.443 |
|
| 2004 |
Gammack D, Doering CR, Kirschner DE. Macrophage response to Mycobacterium tuberculosis infection. Journal of Mathematical Biology. 48: 218-42. PMID 14745511 DOI: 10.1007/S00285-003-0232-8 |
0.445 |
|
| 2004 |
SUD D, JOSEPH IMP, KIRSCHNER D. PREDICTING EFFICACY OF PROTON PUMP INHIBITORS IN REGULATING GASTRIC ACID SECRETION Journal of Biological Systems. 12: 1-34. DOI: 10.1142/S0218339004000999 |
0.317 |
|
| 2003 |
Marino S, Ganguli S, Joseph IM, Kirschner DE. The importance of an inter-compartmental delay in a model for human gastric acid secretion. Bulletin of Mathematical Biology. 65: 963-90. PMID 14607284 DOI: 10.1016/S0092-8240(03)00046-6 |
0.747 |
|
| 2003 |
Ye P, Kourtis AP, Kirschner DE. Reconstitution of thymic function in HIV-1 patients treated with highly active antiretroviral therapy. Clinical Immunology (Orlando, Fla.). 106: 95-105. PMID 12672400 DOI: 10.1016/S1521-6616(02)00024-4 |
0.551 |
|
| 2003 |
Joseph IM, Zavros Y, Merchant JL, Kirschner D. A model for integrative study of human gastric acid secretion. Journal of Applied Physiology (Bethesda, Md. : 1985). 94: 1602-18. PMID 12433865 DOI: 10.1152/Japplphysiol.00281.2002 |
0.737 |
|
| 2002 |
Ye P, Kirschner DE. Measuring emigration of human thymocytes by T-cell receptor excision circles. Critical Reviews in Immunology. 22: 483-97. PMID 12803323 DOI: 10.1615/Critrevimmunol.V22.I5-6.80 |
0.531 |
|
| 2002 |
Ye P, Kourtis AP, Kirschner DE. The effects of different HIV type 1 strains on human thymic function. Aids Research and Human Retroviruses. 18: 1239-51. PMID 12487812 DOI: 10.1089/088922202320886280 |
0.58 |
|
| 2002 |
Murphy BM, Singer BH, Anderson S, Kirschner D. Comparing epidemic tuberculosis in demographically distinct heterogeneous populations. Mathematical Biosciences. 180: 161-85. PMID 12387922 DOI: 10.1016/S0025-5564(02)00133-5 |
0.339 |
|
| 2002 |
Wang L, Li MY, Kirschner DE. Mathematical analysis of the global dynamics of a model for HTLV-I infection and ATL progression Bellman Prize in Mathematical Biosciences. 179: 207-217. PMID 12208616 DOI: 10.1016/S0025-5564(02)00103-7 |
0.454 |
|
| 2002 |
Bajaria SH, Webb G, Cloyd M, Kirschner D. Dynamics of naive and memory CD4+ T lymphocytes in HIV-1 disease progression. Journal of Acquired Immune Deficiency Syndromes (1999). 30: 41-58. PMID 12048362 DOI: 10.1097/00126334-200205010-00006 |
0.777 |
|
| 2002 |
Ye P, Kirschner DE. Reevaluation of T cell receptor excision circles as a measure of human recent thymic emigrants. Journal of Immunology (Baltimore, Md. : 1950). 168: 4968-79. PMID 11994448 DOI: 10.4049/Jimmunol.168.10.4968 |
0.523 |
|
| 2001 |
Sullivan AD, Wigginton J, Kirschner DE. The coreceptor mutation CCR5Δ32 influences the dynamics of HIV epidemics and is selected for by HIV Proceedings of the National Academy of Sciences of the United States of America. 98: 10214-10219. PMID 11517319 DOI: 10.1073/Pnas.181325198 |
0.374 |
|
| 2001 |
Wigginton JE, Kirschner D. A Model to Predict Cell-Mediated Immune Regulatory Mechanisms During Human Infection with Mycobacterium tuberculosis Journal of Immunology. 166: 1951-1967. PMID 11160244 DOI: 10.4049/Jimmunol.166.3.1951 |
0.474 |
|
| 2000 |
Kirschner D, Webb GF, Cloyd M. Model of HIV-1 disease progression based on virus-induced lymph node homing and homing-induced apoptosis of CD4+ lymphocytes. Journal of Acquired Immune Deficiency Syndromes (1999). 24: 352-62. PMID 11015152 DOI: 10.1097/00126334-200008010-00010 |
0.427 |
|
| 2000 |
Falk PG, Syder AJ, Guruge JL, Kirschner D, Blaser MJ, Gordon JI. Theoretical and experimental approaches for studying factors defining the Helicobacter pylori-host relationship. Trends in Microbiology. 8: 321-9. PMID 10878767 DOI: 10.1016/S0966-842X(00)01780-7 |
0.342 |
|
| 1999 |
Blaser MJ, Kirschner D. Dynamics of Helicobacter pylori colonization in relation to the host response Proceedings of the National Academy of Sciences of the United States of America. 96: 8359-8364. PMID 10411880 DOI: 10.1073/Pnas.96.15.8359 |
0.364 |
|
| 1999 |
Kirschner D. Dynamics of co-infection with M. Tuberculosis and HIV-1. Theoretical Population Biology. 55: 94-109. PMID 9925811 DOI: 10.1006/Tpbi.1998.1382 |
0.472 |
|
| 1998 |
Kirschner D, Panetta JC. Modeling immunotherapy of the tumor-immune interaction. Journal of Mathematical Biology. 37: 235-52. PMID 9785481 DOI: 10.1007/S002850050127 |
0.328 |
|
| 1998 |
Kirschner DE, Mehr R, Perelson AS. Role of the thymus in pediatric HIV-1 infection. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association. 18: 95-109. PMID 9637574 DOI: 10.1097/00042560-199806010-00001 |
0.479 |
|
| 1998 |
Kirschner DE, Webb GF. Immunotherapy of HIV-1 Infection Journal of Biological Systems. 6: 71-83. DOI: 10.1142/S0218339098000091 |
0.483 |
|
| 1997 |
Kirschner DE, Webb GF. Resistance, remission, and qualitative differences in HIV chemotherapy. Emerging Infectious Diseases. 3: 273-83. PMID 9284371 DOI: 10.3201/Eid0303.970303 |
0.401 |
|
| 1997 |
Kirschner D, Lenhart S, Serbin S. Optimal control of the chemotherapy of HIV Journal of Mathematical Biology. 35: 775-792. PMID 9269736 DOI: 10.1007/S002850050076 |
0.348 |
|
| 1997 |
Kirschner DE, Webb GF. Understanding drug resistance for monotherapy treatment of HIV infection. Bulletin of Mathematical Biology. 59: 763-85. PMID 9214852 DOI: 10.1007/Bf02458429 |
0.48 |
|
| 1997 |
Kirschner DE, Webb GF. A Mathematical Model of Combined Drug Therapy of HIV Infection Journal of Theoretical Medicine. 1: 25-34. DOI: 10.1080/10273669708833004 |
0.499 |
|
| 1996 |
Kirschner D, Webb GF. A model for treatment strategy in the chemotherapy of AIDS. Bulletin of Mathematical Biology. 58: 376-90. PMID 8713663 DOI: 10.1016/0092-8240(95)00345-2 |
0.37 |
|
| 1996 |
Kirschner DE. A Diffusion Model for AIDS in a Closed, Heterosexual Population: Examining Rates of Infection Siam Journal On Applied Mathematics. 56: 143-166. DOI: 10.1137/S003613999223911X |
0.378 |
|
| 1995 |
Kirschner DE, Blaser MJ. The dynamics of helicobacter pylori infection of the human stomach Journal of Theoretical Biology. 176: 281-290. PMID 7475116 DOI: 10.1006/Jtbi.1995.0198 |
0.402 |
|
| 1993 |
Perelson AS, Kirschner DE, De Boer R. Dynamics of HIV infection of CD4+ T cells. Mathematical Biosciences. 114: 81-125. PMID 8096155 DOI: 10.1016/0025-5564(93)90043-A |
0.461 |
|
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