Year |
Citation |
Score |
2021 |
Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, ... ... Edwards PA, et al. FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. Cell Metabolism. PMID 34270928 DOI: 10.1016/j.cmet.2021.06.012 |
0.33 |
|
2021 |
von Scheidt M, Zhao Y, de Aguiar Vallim TQ, Che N, Wierer M, Seldin MM, Franzén O, Kurt Z, Pang S, Bongiovanni D, Yamamoto M, Edwards PA, Ruusalepp A, Kovacic JC, Mann M, et al. The Transcription Factor MAFF Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism. Circulation. PMID 33626882 DOI: 10.1161/CIRCULATIONAHA.120.050186 |
0.317 |
|
2018 |
Von Scheidt M, Zhao Y, De Aguiar Vallim TQ, Che N, Franzen O, Kurt Z, Yamamoto M, Edwards PA, Ruusalepp A, Kovacic J, Bjorkegren JLM, Lusis AJ, Yang X, Schunkert H. P1844The transcription factor MAFF regulates an atherosclerosis relevant gene network European Heart Journal. 39. DOI: 10.1093/Eurheartj/Ehy565.P1844 |
0.332 |
|
2016 |
Tarling EJ, Edwards PA. Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 27230131 DOI: 10.1161/Atvbaha.116.307414 |
0.305 |
|
2015 |
de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA. MAFG is a transcriptional repressor of bile acid synthesis and metabolism. Cell Metabolism. 21: 298-310. PMID 25651182 DOI: 10.1016/J.Cmet.2015.01.007 |
0.457 |
|
2014 |
Das S, Edwards PA, Crockett JC, Rogers MJ. Upregulation of endogenous farnesyl diphosphate synthase overcomes the inhibitory effect of bisphosphonate on protein prenylation in Hela cells. Biochimica Et Biophysica Acta. 1841: 569-73. PMID 24369118 DOI: 10.1016/J.Bbalip.2013.12.010 |
0.32 |
|
2013 |
Rong X, Albert CJ, Hong C, Duerr MA, Chamberlain BT, Tarling EJ, Ito A, Gao J, Wang B, Edwards PA, Jung ME, Ford DA, Tontonoz P. LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition. Cell Metabolism. 18: 685-97. PMID 24206663 DOI: 10.1016/J.Cmet.2013.10.002 |
0.409 |
|
2013 |
de Aguiar Vallim TQ, Tarling EJ, Edwards PA. Pleiotropic roles of bile acids in metabolism. Cell Metabolism. 17: 657-69. PMID 23602448 DOI: 10.1016/J.Cmet.2013.03.013 |
0.479 |
|
2013 |
Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, Sidhu R, Onken MD, Harbour JW, Hagbi-Levi S, Chowers I, Edwards PA, Baldan A, Parks JS, Ory DS, et al. Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. Cell Metabolism. 17: 549-61. PMID 23562078 DOI: 10.1016/J.Cmet.2013.03.009 |
0.628 |
|
2013 |
de Aguiar Vallim TQ, Tarling EJ, Kim T, Civelek M, Baldán Á, Esau C, Edwards PA. MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor. Circulation Research. 112: 1602-12. PMID 23519696 DOI: 10.1161/Circresaha.112.300648 |
0.696 |
|
2013 |
Tarling EJ, de Aguiar Vallim TQ, Edwards PA. Role of ABC transporters in lipid transport and human disease. Trends in Endocrinology and Metabolism: Tem. 24: 342-50. PMID 23415156 DOI: 10.1016/J.Tem.2013.01.006 |
0.389 |
|
2013 |
Bennett BJ, de Aguiar Vallim TQ, Wang Z, Shih DM, Meng Y, Gregory J, Allayee H, Lee R, Graham M, Crooke R, Edwards PA, Hazen SL, Lusis AJ. Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metabolism. 17: 49-60. PMID 23312283 DOI: 10.1016/J.Cmet.2012.12.011 |
0.416 |
|
2012 |
Zhang Y, Ge X, Heemstra LA, Chen WD, Xu J, Smith JL, Ma H, Kasim N, Edwards PA, Novak CM. Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice. Molecular Endocrinology (Baltimore, Md.). 26: 272-80. PMID 22261820 DOI: 10.1210/Me.2011-1157 |
0.346 |
|
2012 |
Tarling EJ, Edwards PA. Dancing with the sterols: critical roles for ABCG1, ABCA1, miRNAs, and nuclear and cell surface receptors in controlling cellular sterol homeostasis. Biochimica Et Biophysica Acta. 1821: 386-95. PMID 21824529 DOI: 10.1016/J.Bbalip.2011.07.011 |
0.423 |
|
2011 |
Tarling EJ, Edwards PA. ATP binding cassette transporter G1 (ABCG1) is an intracellular sterol transporter. Proceedings of the National Academy of Sciences of the United States of America. 108: 19719-24. PMID 22095132 DOI: 10.1073/Pnas.1113021108 |
0.4 |
|
2011 |
Yin L, Ma H, Ge X, Edwards PA, Zhang Y. Hepatic hepatocyte nuclear factor 4α is essential for maintaining triglyceride and cholesterol homeostasis. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 328-36. PMID 21071704 DOI: 10.1161/Atvbaha.110.217828 |
0.353 |
|
2010 |
Jiang YJ, Lu B, Tarling EJ, Kim P, Man MQ, Crumrine D, Edwards PA, Elias PM, Feingold KR. Regulation of ABCG1 expression in human keratinocytes and murine epidermis. Journal of Lipid Research. 51: 3185-95. PMID 20675829 DOI: 10.1194/Jlr.M006445 |
0.498 |
|
2010 |
Lee FY, de Aguiar Vallim TQ, Chong HK, Zhang Y, Liu Y, Jones SA, Osborne TF, Edwards PA. Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity. Molecular Endocrinology (Baltimore, Md.). 24: 1626-36. PMID 20573685 DOI: 10.1210/Me.2010-0117 |
0.698 |
|
2010 |
Chong HK, Infante AM, Seo YK, Jeon TI, Zhang Y, Edwards PA, Xie X, Osborne TF. Genome-wide interrogation of hepatic FXR reveals an asymmetric IR-1 motif and synergy with LRH-1. Nucleic Acids Research. 38: 6007-17. PMID 20483916 DOI: 10.1093/Nar/Gkq397 |
0.459 |
|
2010 |
Tarling EJ, Bojanic DD, Tangirala RK, Wang X, Lovgren-Sandblom A, Lusis AJ, Bjorkhem I, Edwards PA. Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 1174-80. PMID 20299684 DOI: 10.1161/Atvbaha.110.205617 |
0.772 |
|
2010 |
Zhang Y, Yin L, Anderson J, Ma H, Gonzalez FJ, Willson TM, Edwards PA. Identification of novel pathways that control farnesoid X receptor-mediated hypocholesterolemia. The Journal of Biological Chemistry. 285: 3035-43. PMID 19996107 DOI: 10.1074/Jbc.M109.083899 |
0.52 |
|
2010 |
Bojanic DD, Tarr PT, Gale GD, Smith DJ, Bok D, Chen B, Nusinowitz S, Lövgren-Sandblom A, Björkhem I, Edwards PA. Differential expression and function of ABCG1 and ABCG4 during development and aging. Journal of Lipid Research. 51: 169-81. PMID 19633360 DOI: 10.1194/Jlr.M900250-Jlr200 |
0.799 |
|
2010 |
Lee FY, de Aguiar Vallim TQ, Chong HK, Zhang Y, Liu Y, Jones SA, Osborne TF, Edwards PA. Activation of the Farnesoid X-Activated Receptor Provides Protection against Acetaminophen-Induced Hepatic Toxicity The Journal of Clinical Endocrinology & Metabolism. 95: 3563-3563. DOI: 10.1210/Jcem.95.7.9994 |
0.698 |
|
2009 |
Vallim TQ, Edwards PA. Bile acids have the gall to function as hormones. Cell Metabolism. 10: 162-4. PMID 19723491 DOI: 10.1016/J.Cmet.2009.08.005 |
0.371 |
|
2009 |
A-Gonzalez N, Bensinger SJ, Hong C, Beceiro S, Bradley MN, Zelcer N, Deniz J, Ramirez C, DÃaz M, Gallardo G, de Galarreta CR, Salazar J, Lopez F, Edwards P, Parks J, et al. Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR. Immunity. 31: 245-58. PMID 19646905 DOI: 10.1016/J.Immuni.2009.06.018 |
0.717 |
|
2009 |
Tarr PT, Tarling EJ, Bojanic DD, Edwards PA, Baldán A. Emerging new paradigms for ABCG transporters. Biochimica Et Biophysica Acta. 1791: 584-93. PMID 19416657 DOI: 10.1016/J.Bbalip.2009.01.007 |
0.752 |
|
2009 |
Baldán A, Bojanic DD, Edwards PA. The ABCs of sterol transport. Journal of Lipid Research. 50: S80-5. PMID 18997165 DOI: 10.1194/Jlr.R800044-Jlr200 |
0.829 |
|
2008 |
Bensinger SJ, Bradley MN, Joseph SB, Zelcer N, Janssen EM, Hausner MA, Shih R, Parks JS, Edwards PA, Jamieson BD, Tontonoz P. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell. 134: 97-111. PMID 18614014 DOI: 10.1016/J.Cell.2008.04.052 |
0.727 |
|
2008 |
Baldán A, Gomes AV, Ping P, Edwards PA. Loss of ABCG1 results in chronic pulmonary inflammation. Journal of Immunology (Baltimore, Md. : 1950). 180: 3560-8. PMID 18292583 DOI: 10.4049/Jimmunol.180.5.3560 |
0.659 |
|
2008 |
Zhang Y, Edwards PA. FXR signaling in metabolic disease. Febs Letters. 582: 10-8. PMID 18023284 DOI: 10.1016/J.Febslet.2007.11.015 |
0.411 |
|
2008 |
Tarr PT, Edwards PA. ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2. Journal of Lipid Research. 49: 169-82. PMID 17916878 DOI: 10.1194/Jlr.M700364-Jlr200 |
0.763 |
|
2007 |
Lee H, Hubbert ML, Osborne TF, Woodford K, Zerangue N, Edwards PA. Regulation of the sodium/sulfate co-transporter by farnesoid X receptor alpha. The Journal of Biological Chemistry. 282: 21653-61. PMID 17545158 DOI: 10.1074/Jbc.M700897200 |
0.461 |
|
2007 |
Hubbert ML, Zhang Y, Lee FY, Edwards PA. Regulation of hepatic Insig-2 by the farnesoid X receptor. Molecular Endocrinology (Baltimore, Md.). 21: 1359-69. PMID 17440045 DOI: 10.1210/Me.2007-0089 |
0.71 |
|
2006 |
Lee FY, Lee H, Hubbert ML, Edwards PA, Zhang Y. FXR, a multipurpose nuclear receptor. Trends in Biochemical Sciences. 31: 572-80. PMID 16908160 DOI: 10.1016/J.Tibs.2006.08.002 |
0.66 |
|
2006 |
Baldán A, Pei L, Lee R, Tarr P, Tangirala RK, Weinstein MM, Frank J, Li AC, Tontonoz P, Edwards PA. Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrow. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2301-7. PMID 16888235 DOI: 10.1161/01.Atv.0000240051.22944.Dc |
0.78 |
|
2006 |
Baldán A, Tarr P, Vales CS, Frank J, Shimotake TK, Hawgood S, Edwards PA. Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis. The Journal of Biological Chemistry. 281: 29401-10. PMID 16887795 DOI: 10.1074/Jbc.M606597200 |
0.799 |
|
2006 |
Zhang Y, Wang X, Vales C, Lee FY, Lee H, Lusis AJ, Edwards PA. FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 2316-21. PMID 16825595 DOI: 10.1161/01.Atv.0000235697.35431.05 |
0.602 |
|
2006 |
Baldán A, Tarr P, Lee R, Edwards PA. ATP-binding cassette transporter G1 and lipid homeostasis. Current Opinion in Lipidology. 17: 227-32. PMID 16680026 DOI: 10.1097/01.Mol.0000226113.89812.Bb |
0.778 |
|
2006 |
Zhang Y, Lee FY, Barrera G, Lee H, Vales C, Gonzalez FJ, Willson TM, Edwards PA. Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 1006-11. PMID 16410358 DOI: 10.1073/Pnas.0506982103 |
0.631 |
|
2006 |
Shih DM, Kast-Woelbern HR, Wong J, Xia YR, Edwards PA, Lusis AJ. A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids. Journal of Lipid Research. 47: 384-92. PMID 16269825 DOI: 10.1194/Jlr.M500378-Jlr200 |
0.497 |
|
2006 |
Lee H, Zhang Y, Lee FY, Nelson SF, Gonzalez FJ, Edwards PA. FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine. Journal of Lipid Research. 47: 201-14. PMID 16251721 DOI: 10.1194/Jlr.M500417-Jlr200 |
0.669 |
|
2005 |
Arai S, Shelton JM, Chen M, Bradley MN, Castrillo A, Bookout AL, Mak PA, Edwards PA, Mangelsdorf DJ, Tontonoz P, Miyazaki T. A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis development. Cell Metabolism. 1: 201-13. PMID 16054063 DOI: 10.1016/J.Cmet.2005.02.002 |
0.669 |
|
2005 |
Kennedy MA, Barrera GC, Nakamura K, Baldán A, Tarr P, Fishbein MC, Frank J, Francone OL, Edwards PA. ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation. Cell Metabolism. 1: 121-31. PMID 16054053 DOI: 10.1016/J.Cmet.2005.01.002 |
0.808 |
|
2005 |
Lee FY, Kast-Woelbern HR, Chang J, Luo G, Jones SA, Fishbein MC, Edwards PA. Alpha-crystallin is a target gene of the farnesoid X-activated receptor in human livers. The Journal of Biological Chemistry. 280: 31792-800. PMID 16012168 DOI: 10.1074/Jbc.M503182200 |
0.66 |
|
2005 |
Anisfeld AM, Kast-Woelbern HR, Lee H, Zhang Y, Lee FY, Edwards PA. Activation of the nuclear receptor FXR induces fibrinogen expression: a new role for bile acid signaling. Journal of Lipid Research. 46: 458-68. PMID 15604525 DOI: 10.1194/Jlr.M400292-Jlr200 |
0.823 |
|
2004 |
Nakamura K, Kennedy MA, Baldán A, Bojanic DD, Lyons K, Edwards PA. Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein. The Journal of Biological Chemistry. 279: 45980-9. PMID 15319426 DOI: 10.1074/Jbc.M408652200 |
0.814 |
|
2004 |
Zhang Y, Castellani LW, Sinal CJ, Gonzalez FJ, Edwards PA. Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR. Genes & Development. 18: 157-69. PMID 14729567 DOI: 10.1101/Gad.1138104 |
0.409 |
|
2003 |
Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Molecular Cell. 11: 1079-92. PMID 12718892 DOI: 10.1016/S1097-2765(03)00104-7 |
0.818 |
|
2003 |
Anisfeld AM, Kast-Woelbern HR, Meyer ME, Jones SA, Zhang Y, Williams KJ, Willson T, Edwards PA. Syndecan-1 expression is regulated in an isoform-specific manner by the farnesoid-X receptor. The Journal of Biological Chemistry. 278: 20420-8. PMID 12660231 DOI: 10.1074/Jbc.M302505200 |
0.83 |
|
2003 |
Zhang Y, Kast-Woelbern HR, Edwards PA. Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation. The Journal of Biological Chemistry. 278: 104-10. PMID 12393883 DOI: 10.1074/Jbc.M209505200 |
0.539 |
|
2002 |
Mak PA, Kast-Woelbern HR, Anisfeld AM, Edwards PA. Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors. Journal of Lipid Research. 43: 2037-41. PMID 12454263 DOI: 10.1194/Jlr.C200014-Jlr200 |
0.823 |
|
2002 |
Edwards PA, Kennedy MA, Mak PA. LXRs; oxysterol-activated nuclear receptors that regulate genes controlling lipid homeostasis. Vascular Pharmacology. 38: 249-56. PMID 12449021 DOI: 10.1016/S1537-1891(02)00175-1 |
0.431 |
|
2002 |
Mak PA, Laffitte BA, Desrumaux C, Joseph SB, Curtiss LK, Mangelsdorf DJ, Tontonoz P, Edwards PA. Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta. The Journal of Biological Chemistry. 277: 31900-8. PMID 12032151 DOI: 10.1074/Jbc.M202993200 |
0.761 |
|
2002 |
Edwards PA, Kast HR, Anisfeld AM. BAREing it all: the adoption of LXR and FXR and their roles in lipid homeostasis. Journal of Lipid Research. 43: 2-12. PMID 11792716 |
0.801 |
|
2002 |
Kast HR, Goodwin B, Tarr PT, Jones SA, Anisfeld AM, Stoltz CM, Tontonoz P, Kliewer S, Willson TM, Edwards PA. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. The Journal of Biological Chemistry. 277: 2908-15. PMID 11706036 DOI: 10.1074/Jbc.M109326200 |
0.794 |
|
2001 |
Kast HR, Nguyen CM, Sinal CJ, Jones SA, Laffitte BA, Reue K, Gonzalez FJ, Willson TM, Edwards PA. Farnesoid X-activated receptor induces apolipoprotein C-II transcription: a molecular mechanism linking plasma triglyceride levels to bile acids. Molecular Endocrinology (Baltimore, Md.). 15: 1720-8. PMID 11579204 DOI: 10.1210/Mend.15.10.0712 |
0.82 |
|
2001 |
Kennedy MA, Venkateswaran A, Tarr PT, Xenarios I, Kudoh J, Shimizu N, Edwards PA. Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein. The Journal of Biological Chemistry. 276: 39438-47. PMID 11500512 DOI: 10.1074/Jbc.M105863200 |
0.775 |
|
2001 |
Kast HR, Nguyen CM, Anisfeld AM, Ericsson J, Edwards PA. CTP:phosphocholine cytidylyltransferase, a new sterol- and SREBP-responsive gene. Journal of Lipid Research. 42: 1266-72. PMID 11483628 |
0.805 |
|
2001 |
Chawla A, Boisvert WA, Lee CH, Laffitte BA, Barak Y, Joseph SB, Liao D, Nagy L, Edwards PA, Curtiss LK, Evans RM, Tontonoz P. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Molecular Cell. 7: 161-71. PMID 11172721 DOI: 10.1016/S1097-2765(01)00164-2 |
0.751 |
|
2000 |
Edwards PA, Tabor D, Kast HR, Venkateswaran A. Regulation of gene expression by SREBP and SCAP. Biochimica Et Biophysica Acta. 1529: 103-13. PMID 11111080 DOI: 10.1016/S1388-1981(00)00140-2 |
0.817 |
|
2000 |
Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha. Proceedings of the National Academy of Sciences of the United States of America. 97: 12097-102. PMID 11035776 DOI: 10.1073/Pnas.200367697 |
0.783 |
|
2000 |
Venkateswaran A, Repa JJ, Lobaccaro JM, Bronson A, Mangelsdorf DJ, Edwards PA. Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterols. The Journal of Biological Chemistry. 275: 14700-7. PMID 10799558 DOI: 10.1074/Jbc.275.19.14700 |
0.522 |
|
2000 |
Laffitte BA, Kast HR, Nguyen CM, Zavacki AM, Moore DD, Edwards PA. Identification of the DNA binding specificity and potential target genes for the farnesoid X-activated receptor. The Journal of Biological Chemistry. 275: 10638-47. PMID 10744760 DOI: 10.1074/Jbc.275.14.10638 |
0.789 |
|
1999 |
Edwards PA, Ericsson J. Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Annual Review of Biochemistry. 68: 157-85. PMID 10872447 DOI: 10.1146/Annurev.Biochem.68.1.157 |
0.401 |
|
1999 |
Tabor DE, Kim JB, Spiegelman BM, Edwards PA. Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2. The Journal of Biological Chemistry. 274: 20603-10. PMID 10400691 DOI: 10.1074/Jbc.274.29.20603 |
0.448 |
|
1999 |
Ericsson J, Usheva A, Edwards PA. YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes. The Journal of Biological Chemistry. 274: 14508-13. PMID 10318878 DOI: 10.1074/jbc.274.20.14508 |
0.42 |
|
1998 |
Edwards PA, Ericsson J. Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease. Current Opinion in Lipidology. 9: 433-40. PMID 9812197 DOI: 10.1097/00041433-199810000-00007 |
0.407 |
|
1998 |
Tabor DE, Kim JB, Spiegelman BM, Edwards PA. Transcriptional activation of the stearoyl-CoA desaturase 2 gene by sterol regulatory element-binding protein/adipocyte determination and differentiation factor 1. The Journal of Biological Chemistry. 273: 22052-8. PMID 9705348 DOI: 10.1074/Jbc.273.34.22052 |
0.475 |
|
1998 |
Ericsson J, Edwards PA. CBP is required for sterol-regulated and sterol regulatory element-binding protein-regulated transcription. The Journal of Biological Chemistry. 273: 17865-70. PMID 9651391 DOI: 10.1074/Jbc.273.28.17865 |
0.516 |
|
1997 |
Jackson SM, Ericsson J, Edwards PA. Signaling molecules derived from the cholesterol biosynthetic pathway. Sub-Cellular Biochemistry. 28: 1-21. PMID 9090289 DOI: 10.1007/978-1-4615-5901-6_1 |
0.329 |
|
1997 |
Ericsson J, Jackson SM, Kim JB, Spiegelman BM, Edwards PA. Identification of glycerol-3-phosphate acyltransferase as an adipocyte determination and differentiation factor 1- and sterol regulatory element-binding protein-responsive gene. The Journal of Biological Chemistry. 272: 7298-305. PMID 9054427 DOI: 10.1074/Jbc.272.11.7298 |
0.454 |
|
1996 |
Ericsson J, Jackson SM, Edwards PA. Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene. The Journal of Biological Chemistry. 271: 24359-64. PMID 8798690 DOI: 10.1074/Jbc.271.40.24359 |
0.408 |
|
1996 |
Navab M, Berliner JA, Watson AD, Hama SY, Territo MC, Lusis AJ, Shih DM, Van Lenten BJ, Frank JS, Demer LL, Edwards PA, Fogelman AM. The Yin and Yang of oxidation in the development of the fatty streak. A review based on the 1994 George Lyman Duff Memorial Lecture. Arteriosclerosis, Thrombosis, and Vascular Biology. 16: 831-42. PMID 8673557 DOI: 10.1161/01.Atv.16.7.831 |
0.366 |
|
1996 |
Ericsson J, Jackson SM, Lee BC, Edwards PA. Sterol regulatory element binding protein binds to a cis element in the promoter of the farnesyl diphosphate synthase gene. Proceedings of the National Academy of Sciences of the United States of America. 93: 945-50. PMID 8570665 DOI: 10.1073/Pnas.93.2.945 |
0.441 |
|
1996 |
Edwards PA, Davis R. Chapter 13 Isoprenoids, sterols and bile acids New Comprehensive Biochemistry. 31: 341-362. DOI: 10.1016/S0167-7306(08)60520-7 |
0.304 |
|
1995 |
Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edwards PA, Watson AD, Lusis AJ. Atherosclerosis: basic mechanisms. Oxidation, inflammation, and genetics. Circulation. 91: 2488-96. PMID 7729036 DOI: 10.1161/01.Cir.91.9.2488 |
0.373 |
|
1995 |
Jackson SM, Ericsson J, Osborne TF, Edwards PA. NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes. The Journal of Biological Chemistry. 270: 21445-8. PMID 7665553 DOI: 10.1074/Jbc.270.37.21445 |
0.47 |
|
1995 |
Navab M, Fogelman AM, Berliner JA, Territo MC, Demer LL, Frank JS, Watson AD, Edwards PA, Lusis AJ. Pathogenesis of atherosclerosis. The American Journal of Cardiology. 76: 18C-23C. PMID 7572682 DOI: 10.1016/S0002-9149(99)80466-4 |
0.421 |
|
1992 |
Bork RW, Svenson KL, Mehrabian M, Lusis AJ, Fogelman AM, Edwards PA. Mechanisms controlling competence gene expression in murine fibroblasts stimulated with minimally modified LDL. Arteriosclerosis and Thrombosis : a Journal of Vascular Biology. 12: 800-6. PMID 1616905 DOI: 10.1161/01.Atv.12.7.800 |
0.422 |
|
1991 |
Teruya JH, Salido EC, Edwards PA, Clarke CF. Testis-specific transcripts of rat farnesyl pyrophosphate synthetase are developmentally regulated and localized to haploid germ cells. Biology of Reproduction. 44: 663-71. PMID 2043737 DOI: 10.1095/Biolreprod44.4.663 |
0.588 |
|
1991 |
Edwards PA. Chapter 13 Regulation of sterol biosynthesis and isoprenylation of proteins New Comprehensive Biochemistry. 20: 383-401. DOI: 10.1016/S0167-7306(08)60341-5 |
0.461 |
|
1990 |
Teruya JH, Kutsunai SY, Spear DH, Edwards PA, Clarke CF. Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA. Molecular and Cellular Biology. 10: 2315-26. PMID 2325654 DOI: 10.1128/mcb.10.5.2315-2326.1990 |
0.623 |
|
1989 |
Heinzmann C, Clarke CF, Klisak I, Mohandas T, Sparkes RS, Edwards PA, Lusis AJ. Dispersed family of human genes with sequence similarity to farnesyl pyrophosphate synthetase. Genomics. 5: 493-500. PMID 2613235 DOI: 10.1016/0888-7543(89)90015-3 |
0.567 |
|
1989 |
Levin MS, Pitt AJ, Schwartz AL, Edwards PA, Gordon JI. Developmental changes in the expression of genes involved in cholesterol biosynthesis and lipid transport in human and rat fetal and neonatal livers. Biochimica Et Biophysica Acta. 1003: 293-300. PMID 2472835 DOI: 10.1016/0005-2760(89)90235-X |
0.416 |
|
1988 |
Fogelman AM, Van Lenten BJ, Warden C, Haberland ME, Edwards PA. Macrophage lipoprotein receptors. Journal of Cell Science. Supplement. 9: 135-49. PMID 2855802 DOI: 10.1242/Jcs.1988.Supplement_9.7 |
0.448 |
|
1987 |
Clarke CF, Tanaka RD, Svenson K, Wamsley M, Fogelman AM, Edwards PA. Molecular cloning and sequence of a cholesterol-repressible enzyme related to prenyltransferase in the isoprene biosynthetic pathway. Molecular and Cellular Biology. 7: 3138-46. PMID 3670308 DOI: 10.1128/mcb.7.9.3138-3146.1987 |
0.603 |
|
1987 |
Clarke CF, Edwards PA, Fogelman AM. Chapter 8 Cellular regulation of cholesterol metabolism New Comprehensive Biochemistry. 14: 261-276. DOI: 10.1016/S0167-7306(08)60202-1 |
0.619 |
|
1986 |
Navab M, Hough GP, Berliner JA, Frank JA, Fogelman AM, Haberland ME, Edwards PA. Rabbit beta-migrating very low density lipoprotein increases endothelial macromolecular transport without altering electrical resistance. The Journal of Clinical Investigation. 78: 389-97. PMID 3734098 DOI: 10.1172/Jci112589 |
0.374 |
|
1986 |
Van Lenten BJ, Fogelman AM, Haberland ME, Edwards PA. The role of lipoproteins and receptor-mediated endocytosis in the transport of bacterial lipopolysaccharide. Proceedings of the National Academy of Sciences of the United States of America. 83: 2704-8. PMID 3517876 DOI: 10.1073/Pnas.83.8.2704 |
0.35 |
|
1985 |
Clarke CF, Fogelman AM, Edwards PA. Transcriptional regulation of the 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in rat liver. The Journal of Biological Chemistry. 260: 14363-7. PMID 3850901 |
0.577 |
|
1984 |
Clarke CF, Fogelman AM, Edwards PA. Diurnal rhythm of rat liver mRNAs encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase. Correlation of functional and total mRNA levels with enzyme activity and protein. The Journal of Biological Chemistry. 259: 10439-47. PMID 6540773 |
0.536 |
|
1984 |
Baker DP, van Lenten BJ, Fogelman AM, Edwards PA, Kean C, Berliner JA. LDL, scavenger, and β-VLDL receptors on aortic endothelial cells Arteriosclerosis. 4: 248-255. PMID 6324733 DOI: 10.1161/01.Atv.4.3.248 |
0.37 |
|
1983 |
Clarke CF, Edwards PA, Lan SF, Tanaka RD, Fogelman AM. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase mRNA levels in rat liver. Proceedings of the National Academy of Sciences of the United States of America. 80: 3305-8. PMID 6190175 DOI: 10.1073/Pnas.80.11.3305 |
0.578 |
|
1982 |
Haberland ME, Fogelman AM, Edwards PA. Specificity of receptor-mediated recognition of malondialdehyde-modified low density lipoproteins. Proceedings of the National Academy of Sciences of the United States of America. 79: 1712-6. PMID 6281781 DOI: 10.1073/Pnas.79.6.1712 |
0.423 |
|
1982 |
Fogelman AM, Seager J, Haberland ME, Hokom M, Tanaka R, Edwards PA. Lymphocyte-conditioned medium protects human monocyte-macrophages from cholesteryl ester accumulation. Proceedings of the National Academy of Sciences of the United States of America. 79: 922-6. PMID 6278500 DOI: 10.1073/Pnas.79.3.922 |
0.371 |
|
1980 |
Fogelman AM, Shechter I, Seager J, Hokom M, Child JS, Edwards PA. Malondialdehyde alteration of low density lipoproteins leads to cholesteryl ester accumulation in human monocyte-macrophages. Proceedings of the National Academy of Sciences of the United States of America. 77: 2214-8. PMID 6769124 DOI: 10.1073/Pnas.77.4.2214 |
0.37 |
|
1977 |
Fogelman AM, Seager J, Edwards PA, Hokom M, Popják G. Cholesterol biosynthesis in human lymphocytes, monocytes, and granulocytes. Biochemical and Biophysical Research Communications. 76: 167-73. PMID 869944 DOI: 10.1016/0006-291X(77)91682-5 |
0.323 |
|
1976 |
Edwards PA, Fogelman AM, Popják G. A direct relationship between the amount of sterol lost from rat hepatocytes and the increase in activity of HMG-CoA reductase. Biochemical and Biophysical Research Communications. 68: 64-9. PMID 1247463 DOI: 10.1016/0006-291X(76)90010-3 |
0.381 |
|
1974 |
Edwards PA, Gould RG. Dependence of the circadian rhythm of hepatic beta-hydroxy-beta-methylglutaryl coenzyme A on ribonucleic acid synthesis. A possible second site of inhibition by dietary cholesterol. The Journal of Biological Chemistry. 249: 2891-6. PMID 4828326 |
0.578 |
|
1972 |
Edwards PA, Muroya H, Gould RG. In vivo demonstration of the circadian thythm of cholesterol biosynthesis in the liver and intestine of the rat. Journal of Lipid Research. 13: 396-401. PMID 5025468 |
0.617 |
|
1972 |
Edwards PA, Gould RG. Turnover rate of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase as determined by use of cycloheximide. The Journal of Biological Chemistry. 247: 1520-4. PMID 5012320 |
0.54 |
|
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