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Filip Bednar, Ph.D. - Publications

Affiliations: 
2007 Temple University, Philadelphia, PA, United States 
Area:
Immunology, Molecular Biology, Cell Biology
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50 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Yan W, Menjivar RE, Bonilla ME, Steele NG, Kemp SB, Du W, Donahue KL, Brown K, Carpenter ES, Avritt FR, Irizarry-Negron VM, Yang S, Burns WR, Zhang Y, Pasca di Magliano M, ... Bednar F, et al. Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer. Cancer Immunology Research. PMID 37931247 DOI: 10.1158/2326-6066.CIR-23-0037  0.322
2023 Carpenter ES, Kadiyala P, Elhossiny AM, Kemp SB, Li J, Steele NG, Nicolle R, Nwosu ZC, Freeman J, Dai H, Paglia D, Du W, Donahue K, Morales J, Medina-Cabrera PI, ... ... Bednar F, et al. KRT17High/CXCL8+ tumor cells display both classical and basal features and regulate myeloid infiltration in the pancreatic cancer microenvironment. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 37851080 DOI: 10.1158/1078-0432.CCR-23-1421  0.349
2023 Bednar F, Pasca di Magliano M. Calligraphy tool offers clues to the origin of pancreatic cancer. Nature. 621: 265-266. PMID 37587278 DOI: 10.1038/d41586-023-02518-4  0.31
2023 Menjivar RE, Nwosu ZC, Du W, Donahue KL, Hong HS, Espinoza C, Brown K, Velez-Delgado A, Yan W, Lima F, Bischoff A, Kadiyala P, Salas-Escabillas D, Crawford HC, Bednar F, et al. Arginase 1 is a key driver of immune suppression in pancreatic cancer. Elife. 12. PMID 36727849 DOI: 10.7554/eLife.80721  0.363
2023 Yan W, Steele NG, Kemp SB, Menjivar RE, Du W, Carpenter ES, Donahue KL, Brown KL, Irizarry-Negron V, Yang S, Burns WR, Zhang Y, di Magliano MP, Bednar F. Notch signaling regulates immunosuppressive tumor-associated macrophage function in pancreatic cancer. Biorxiv : the Preprint Server For Biology. PMID 36711890 DOI: 10.1101/2023.01.11.523584  0.327
2022 Scales MK, Velez-Delgado A, Steele NG, Schrader HE, Stabnick AM, Yan W, Mercado Soto NM, Nwosu ZC, Johnson C, Zhang Y, Salas-Escabillas DJ, Menjivar RE, Maurer HC, Crawford HC, Bednar F, et al. Combinatorial Gli activity directs immune infiltration and tumor growth in pancreatic cancer. Plos Genetics. 18: e1010315. PMID 35867772 DOI: 10.1371/journal.pgen.1010315  0.386
2022 Velez-Delgado A, Donahue KL, Du W, Irizarry-Negron V, Menjivar RE, Lasse Opsahl EL, Steele NG, The S, Lazarus J, Sirihorachai VR, Yan W, Kemp SB, Kerk SA, Bollampally M, Yang S, ... ... Bednar F, et al. Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming. Cellular and Molecular Gastroenterology and Hepatology. PMID 35245687 DOI: 10.1016/j.jcmgh.2022.02.016  0.334
2021 Thompson JK, Bednar F. Clinical Utility of Epigenetic Changes in Pancreatic Adenocarcinoma. Epigenomes. 5. PMID 34968245 DOI: 10.3390/epigenomes5040020  0.31
2021 Steele NG, Biffi G, Kemp SB, Zhang Y, Drouillard D, Syu LJ, Hao Y, Oni TE, Brosnan E, Elyada E, Doshi A, Hansma C, Espinoza C, Abbas A, The S, ... ... Bednar F, et al. Inhibition of Hedgehog signaling alters fibroblast composition in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 33495315 DOI: 10.1158/1078-0432.CCR-20-3715  0.329
2020 Hoffman MT, Kemp SB, Salas-Escabillas DJ, Zhang Y, Steele NG, The S, Long D, Benitz S, Yan W, Margolskee RF, Bednar F, Pasca di Magliano M, Wen HJ, Crawford HC. The Gustatory Sensory G-Protein GNAT3 Suppresses Pancreatic Cancer Progression in Mice. Cellular and Molecular Gastroenterology and Hepatology. PMID 32882403 DOI: 10.1016/J.Jcmgh.2020.08.011  0.406
2020 Bednar F, Pasca di Magliano M. Chemotherapy and Tumor Evolution Shape Pancreatic Cancer Recurrence after Resection. Cancer Discovery. 10: 762-764. PMID 32482663 DOI: 10.1158/2159-8290.Cd-20-0359  0.395
2020 Garcia PE, Adoumie M, Kim EC, Zhang Y, Scales MK, El-Tawil YS, Shaikh AZ, Wen HJ, Bednar F, Allen BL, Wellik DM, Crawford HC, Pasca di Magliano M. Differential contribution of pancreatic fibroblast subsets to the pancreatic cancer stroma. Cellular and Molecular Gastroenterology and Hepatology. PMID 32454112 DOI: 10.1016/J.Jcmgh.2020.05.004  0.399
2020 Bednar F, Pasca di Magliano M. Context-Dependent Immune Responses Explain Pancreatic Cancer Immunoresistance. Cancer Cell. 37: 261-263. PMID 32183944 DOI: 10.1016/J.Ccell.2020.02.010  0.405
2020 Zhang Y, Lazarus J, Steele NG, Yan W, Lee HJ, Nwosu ZC, Halbrook CJ, Menjivar RE, Kemp SB, Sirihorachai V, Velez-Delgado A, Donahue K, Carpenter ES, Brown KL, Irizarry-Negron V, ... ... Bednar F, et al. Regulatory T cell depletion alters the tumor microenvironment and accelerates pancreatic carcinogenesis. Cancer Discovery. PMID 31911451 DOI: 10.1158/2159-8290.Cd-19-0958  0.483
2020 Carpenter E, Steele N, Kemp S, Sirihorachai V, Delrosario L, Gunchick V, Donahue K, Rao A, Anderson MA, Crawford H, Frankel T, Bednar F, Magliano MPD. Sa1422 USING ENDOSCOPIC FINE NEEDLE BIOPSIES TO MAP THE IMMUNE LANDSCAPE IN HUMAN PANCREATIC CANCER Gastrointestinal Endoscopy. 91. DOI: 10.1016/J.Gie.2020.03.1155  0.372
2019 Kamarajah SK, Sonnenday CJ, Cho CS, Frankel TL, Bednar F, Lawrence TS, Nathan H. Association of Adjuvant Radiotherapy With Survival After Margin-negative Resection of Pancreatic Ductal Adenocarcinoma: A Propensity-matched National Cancer Database (NCDB) Analysis. Annals of Surgery. PMID 30817352 DOI: 10.1097/SLA.0000000000003242  0.338
2019 Zhang Y, Lazarus J, Steele N, Lee H, Yan W, Halbrook CJ, Menjivar R, Kemp SB, Sirihoracai V, Carpenter ES, Nevison AC, Vinta A, Anderson MA, Crawford HC, Lyssiotis CA, ... ... Bednar F, et al. Abstract I04: Regulatory T-cell depletion causes compensatory immune suppression and accelerates pancreatic carcinogenesis Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-I04  0.492
2019 Thompson JK, Wu E, Alkhalili O, Crawford HC, Magliano MPd, Bednar F. Abstract C56: Bmi1 is widely expressed in acini and regulates Kras-driven transcription factor networks in early pancreatic neoplasia Robotics and Autonomous Systems. 79. DOI: 10.1158/1538-7445.Panca19-C56  0.393
2019 Zhang Y, Lazarus J, Steele N, Yan W, Lee H, Halbrook CJ, Menjivar R, Kemp SB, Sirihorachai V, Carpenter ES, Nevison AC, Vinta A, Anderson MA, Crawford HC, Lyssiotis CA, ... ... Bednar F, et al. Abstract A62: Regulatory T-cell depletion promotes oncogenic Kras-driven pancreatic carcinogenesis Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A62  0.482
2019 Yan W, Zhang Y, Menjivar R, Bednar F, Magliano MPd, Burns WR. Abstract A58: Notch signaling is a key regulator for immune-suppressive function of tumor-associated macrophages in pancreatic adenocarcinoma Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A58  0.406
2019 Steele N, Kemp S, Irizarry-Negron V, Sirihorachai V, Abbas A, Carpenter E, Halbrook C, Espinoza C, Lyssiotis C, Crawford H, Frankel T, Bednar F, Allen B, Magliano MPd. Abstract A52: Modulation of Hedgehog signaling alters immune infiltration in pancreatic cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A52  0.452
2019 Kemp S, Steele N, Carpenter E, Sirihorachai V, Bushnell G, Morris A, Espinoza C, Lima F, Nwosu Z, Orbach S, Shea L, Bednar F, Crawford H, Magliano MPd. Abstract A25: Using biomaterial scaffolds to study the genesis of the immunosuppressive premetastatic niche in pancreatic cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A25  0.446
2019 Hoffman MT, Salas-Escabillas DJ, DelGiorno KE, Bednar F, Margolskee RF, Rao A, Crawford HC. Abstract A19: The role of metaplastic tuft cell chemosensory signaling in pancreatic cancer Cancer Research. 79. DOI: 10.1158/1538-7445.Panca19-A19  0.475
2018 Perusina Lanfranca M, Thompson JK, Bednar F, Halbrook C, Lyssiotis C, Levi B, Frankel TL. Metabolism and Epigenetics of Pancreatic Cancer Stem Cells. Seminars in Cancer Biology. PMID 30273655 DOI: 10.1016/J.Semcancer.2018.09.008  0.385
2018 Kamarajah SK, Sonnenday CJ, Cho CS, Frankel TL, Bednar F, Nathan H. Association of Adjuvant Radiotherapy with Survival after Margin-Negative (R0) Resection of Pancreatic Ductal Adenocarcinoma: A Propensity Score-Matched National Cancer Database Analysis Journal of the American College of Surgeons. 227. DOI: 10.1016/J.Jamcollsurg.2018.07.360  0.361
2016 Bednar F, Ocuin LM, Steve J, Zenati MS, Winters S, Hogg ME, Bahary N, Zeh HJ, Zureikat AH. FOLFIRINOX and gemcitabine/nab-paclitaxel efficacy in the treatment of locally advanced unresectable pancreatic adenocarcinoma. Journal of Clinical Oncology. 34: 399-399. DOI: 10.1200/Jco.2016.34.4_Suppl.399  0.313
2015 Bednar F, Schofield HK, Collins MA, Yan W, Zhang Y, Shyam N, Eberle JA, Almada LL, Olive KP, Bardeesy N, Fernandez-Zapico ME, Nakada D, Simeone DM, Morrison SJ, Pasca di Magliano M. Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism. Carcinogenesis. PMID 25939753 DOI: 10.1093/Carcin/Bgv058  0.448
2015 Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Zhang Y, Leflein J, Waghray M, Owens S, Wilkinson JE, Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, et al. ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis. Genes & Development. 29: 171-83. PMID 25593307 DOI: 10.1101/Gad.253591.114  0.418
2015 Zhang Y, Yan W, Mathew E, Bednar F, Wan S, Collins MA, Evans RA, Welling TH, Vonderheide RH, Magliano MPd. Abstract A48: CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A48  0.359
2015 Schofield H, Bednar F, Collins M, Yan W, Zhang Y, Shyam N, Eberle J, Olive K, Bardeesy N, Nakada D, Simeone D, Morrison S, Magliano MPd. Abstract LB-061: Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism Cancer Research. 75. DOI: 10.1158/1538-7445.Am2015-Lb-061  0.407
2014 Zhang Y, Yan W, Mathew E, Bednar F, Wan S, Collins MA, Evans RA, Welling TH, Vonderheide RH, di Magliano MP. CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice. Cancer Immunology Research. 2: 423-35. PMID 24795355 DOI: 10.1158/2326-6066.Cir-14-0016-T  0.397
2014 Bednar F, Song C, Bardi G, Cornwell W, Rogers TJ. Cross-desensitization of CCR1, but not CCR2, following activation of the formyl peptide receptor FPR1. Journal of Immunology (Baltimore, Md. : 1950). 192: 5305-13. PMID 24778447 DOI: 10.4049/Jimmunol.1302983  0.36
2014 Abel EV, Kim EJ, Wu J, Hynes M, Bednar F, Proctor E, Wang L, Dziubinski ML, Simeone DM. The Notch pathway is important in maintaining the cancer stem cell population in pancreatic cancer. Plos One. 9: e91983. PMID 24647545 DOI: 10.1371/Journal.Pone.0091983  0.456
2014 Zhang Y, Yan W, Bednar F, Wan S, Collins MA, Evans RA, Mathew E, Welling TH, Vonderheide RH, Magliano MPd. Abstract IA12: Oncogenic KRAS and the inflammatory microenvironment in pancreatic cancer Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-Ia12  0.472
2014 Zhang Y, Yan W, Mathew E, Bednar F, Wan S, Collins MA, Evans RA, Welling TH, Vonderheide RH, Magliano MPd. Abstract B23: CD4+ T lymphocytes promote pancreatic cancer progression by suppressing anti-tumor immune responses Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B23  0.418
2013 Zhang Y, Yan W, Collins MA, Bednar F, Rakshit S, Zetter BR, Stanger BZ, Chung I, Rhim AD, di Magliano MP. Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. Cancer Research. 73: 6359-74. PMID 24097820 DOI: 10.1158/0008-5472.Can-13-1558-T  0.388
2013 Proctor E, Waghray M, Lee CJ, Heidt DG, Yalamanchili M, Li C, Bednar F, Simeone DM. Bmi1 enhances tumorigenicity and cancer stem cell function in pancreatic adenocarcinoma. Plos One. 8: e55820. PMID 23437065 DOI: 10.1371/Journal.Pone.0055820  0.428
2013 Bednar F, Collins MA, Yan W, Zhang Y, Nakada D, Simeone DM, Morrison SJ, Pasca di Magliano M. Bmi1 is required for murine pancreatic cancer initiation Journal of the American College of Surgeons. 217: S133. DOI: 10.1016/J.Jamcollsurg.2013.07.309  0.422
2012 Collins MA, Brisset JC, Zhang Y, Bednar F, Pierre J, Heist KA, Galbán CJ, Galbán S, di Magliano MP. Metastatic pancreatic cancer is dependent on oncogenic Kras in mice. Plos One. 7: e49707. PMID 23226501 DOI: 10.1371/Journal.Pone.0049707  0.452
2012 Bednar F, Simeone DM. Metformin and cancer stem cells: old drug, new targets. Cancer Prevention Research (Philadelphia, Pa.). 5: 351-4. PMID 22389436 DOI: 10.1158/1940-6207.Capr-12-0026  0.371
2012 Collins MA, Bednar F, Zhang Y, Brisset JC, Galbán S, Galbán CJ, Rakshit S, Flannagan KS, Adsay NV, Pasca di Magliano M. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. The Journal of Clinical Investigation. 122: 639-53. PMID 22232209 DOI: 10.1172/Jci59227  0.48
2012 Bednar F, Zhang Y, Nakada D, Simeone DM, Morrison SJ, Magliano MPd. Abstract B59: Bmi1 is required for murine pancreatic cancer initiation. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-B59  0.441
2012 Wang L, Yang H, Bednar F, Zhang Y, Leflein J, Detzler T, Ney GM, Magliano MPd, Simeone DM. Abstract B49: ATDC synergizes with oncogenic Kras to induce invasive pancreatic adeno-carcinoma in transgenic mice. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-B49  0.384
2012 Zhang Y, Bednar F, Yan W, Collins MA, Rakshit S, Magliano MPD. Abstract A104: IL6 signaling is required for pancreatitis-induced pancreatic intra-epithelial neoplasia progression and maintenance in mice. Cancer Research. 72. DOI: 10.1158/1538-7445.Panca2012-A104  0.346
2011 Bednar F, Simeone DM. Pancreatic cancer stem cell biology and its therapeutic implications. Journal of Gastroenterology. 46: 1345-52. PMID 22048257 DOI: 10.1007/S00535-011-0494-7  0.45
2011 Song C, Rahim RT, Davey PC, Bednar F, Bardi G, Zhang L, Zhang N, Oppenheim JJ, Rogers TJ. Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5. The Journal of Biological Chemistry. 286: 20354-65. PMID 21454526 DOI: 10.1074/Jbc.M110.177303  0.367
2009 Bednar F, Simeone DM. Pancreatic cancer stem cells and relevance to cancer treatments. Journal of Cellular Biochemistry. 107: 40-5. PMID 19301275 DOI: 10.1002/Jcb.22093  0.432
2004 Sun R, Iribarren P, Zhang N, Zhou Y, Gong W, Cho EH, Lockett S, Chertov O, Bednar F, Rogers TJ, Oppenheim JJ, Wang JM. Identification of neutrophil granule protein cathepsin G as a novel chemotactic agonist for the G protein-coupled formyl peptide receptor. Journal of Immunology (Baltimore, Md. : 1950). 173: 428-36. PMID 15210802 DOI: 10.4049/Jimmunol.173.1.428  0.34
2003 Szabo I, Wetzel MA, Zhang N, Steele AD, Kaminsky DE, Chen C, Liu-Chen LY, Bednar F, Henderson EE, Howard OM, Oppenheim JJ, Rogers TJ. Selective inactivation of CCR5 and decreased infectivity of R5 HIV-1 strains mediated by opioid-induced heterologous desensitization. Journal of Leukocyte Biology. 74: 1074-82. PMID 12972507 DOI: 10.1189/Jlb.0203067  0.588
2002 Steele AD, Szabo I, Bednar F, Rogers TJ. Interactions between opioid and chemokine receptors: heterologous desensitization. Cytokine & Growth Factor Reviews. 13: 209-22. PMID 12486875 DOI: 10.1016/S1359-6101(02)00007-2  0.34
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