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Philip J. Kranzusch, Ph.D. - Publications

Affiliations: 
Microbiology & Immunobiology Harvard Medical School, Boston, MA, United States 
 2012 Biology: Medical Sciences, Division of Harvard University, Cambridge, MA, United States 
Area:
Virology Biology, Biochemistry, Microbiology Biology
Website:
http://kranzuschlab.med.harvard.edu/people.html
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52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Antine SP, Johnson AG, Mooney SE, Leavitt A, Mayer ML, Yirmiya E, Amitai G, Sorek R, Kranzusch PJ. Structural basis of Gabija anti-phage defence and viral immune evasion. Nature. PMID 37992757 DOI: 10.1038/s41586-023-06855-2  0.368
2023 Yirmiya E, Leavitt A, Lu A, Ragucci AE, Avraham C, Osterman I, Garb J, Antine SP, Mooney SE, Hobbs SJ, Kranzusch PJ, Amitai G, Sorek R. Phages overcome bacterial immunity via diverse anti-defence proteins. Nature. PMID 37992756 DOI: 10.1038/s41586-023-06869-w  0.301
2023 Govande AA, Babnis AW, Urban C, Habjan M, Hartmann R, Kranzusch PJ, Pichlmair A. RNase L-activating 2'-5' oligoadenylates bind ABCF1, ABCF3 and Decr-1. The Journal of General Virology. 104. PMID 37676257 DOI: 10.1099/jgv.0.001890  0.324
2023 Slavik KM, Kranzusch PJ. CBASS to cGAS-STING: The Origins and Mechanisms of Nucleotide Second Messenger Immune Signaling. Annual Review of Virology. PMID 37380187 DOI: 10.1146/annurev-virology-111821-115636  0.33
2023 Li Y, Slavik KM, Toyoda HC, Morehouse BR, de Oliveira Mann CC, Elek A, Levy S, Wang Z, Mears KS, Liu J, Kashin D, Guo X, Mass T, Sebé-Pedrós A, Schwede F, ... Kranzusch PJ, et al. cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell. PMID 37379839 DOI: 10.1016/j.cell.2023.05.038  0.342
2023 Richmond-Buccola D, Hobbs SJ, Garcia JM, Toyoda H, Gao J, Shao S, Lee ASY, Kranzusch PJ. Convergent mutations in phage virion assembly proteins enable evasion of Type I CBASS immunity. Biorxiv : the Preprint Server For Biology. PMID 37292831 DOI: 10.1101/2023.05.21.541620  0.319
2023 Cai H, Li L, Slavik K, Huang J, Yin T, Hédelin L, Xiang Z, Yang Y, Li X, Chen Y, Wei Z, Deng H, Chen D, Jiao R, Martins N, ... ... Kranzusch P, et al. A novel virus-induced cyclic dinucleotide, 2'3'-c-di-GMP, mediates STING-dependent antiviral immunity in . Biorxiv : the Preprint Server For Biology. PMID 37214844 DOI: 10.1101/2023.05.08.539652  0.333
2023 Li Y, Slavik KM, Morehouse BR, de Oliveira Mann CC, Mears K, Liu J, Kashin D, Schwede F, Kranzusch PJ. cGLRs are a diverse family of pattern recognition receptors in animal innate immunity. Biorxiv : the Preprint Server For Biology. PMID 36865129 DOI: 10.1101/2023.02.22.529553  0.344
2023 Duncan-Lowey B, Tal N, Johnson AG, Rawson S, Mayer ML, Doron S, Millman A, Melamed S, Fedorenko T, Kacen A, Brandis A, Mehlman T, Amitai G, Sorek R, Kranzusch PJ. Cryo-EM structure of the RADAR supramolecular anti-phage defense complex. Cell. PMID 36764290 DOI: 10.1016/j.cell.2023.01.012  0.322
2022 Leavitt A, Yirmiya E, Amitai G, Lu A, Garb J, Herbst E, Morehouse BR, Hobbs SJ, Antine SP, Sun ZJ, Kranzusch PJ, Sorek R. Viruses inhibit TIR gcADPR signaling to overcome bacterial defense. Nature. PMID 36174646 DOI: 10.1038/s41586-022-05375-9  0.32
2022 Zhou W, Richmond-Buccola D, Wang Q, Kranzusch PJ. Structural basis of human TREX1 DNA degradation and autoimmune disease. Nature Communications. 13: 4277. PMID 35879334 DOI: 10.1038/s41467-022-32055-z  0.371
2022 Hertzog J, Zhou W, Fowler G, Rigby RE, Bridgeman A, Blest HT, Cursi C, Chauveau L, Davenne T, Warner BE, Kinchington PR, Kranzusch PJ, Rehwinkel J. Varicella-Zoster virus ORF9 is an antagonist of the DNA sensor cGAS. The Embo Journal. e109217. PMID 35670106 DOI: 10.15252/embj.2021109217  0.351
2022 Hobbs SJ, Wein T, Lu A, Morehouse BR, Schnabel J, Leavitt A, Yirmiya E, Sorek R, Kranzusch PJ. Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Nature. PMID 35395152 DOI: 10.1038/s41586-022-04716-y  0.356
2022 Duncan-Lowey B, Kranzusch PJ. CBASS phage defense and evolution of antiviral nucleotide signaling. Current Opinion in Immunology. 74: 156-163. PMID 35123147 DOI: 10.1016/j.coi.2022.01.002  0.348
2021 Tal N, Morehouse BR, Millman A, Stokar-Avihail A, Avraham C, Fedorenko T, Yirmiya E, Herbst E, Brandis A, Mehlman T, Oppenheimer-Shaanan Y, Keszei AFA, Shao S, Amitai G, Kranzusch PJ, et al. Cyclic CMP and cyclic UMP mediate bacterial immunity against phages. Cell. PMID 34644530 DOI: 10.1016/j.cell.2021.09.031  0.332
2021 Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ. cGAS-like receptors sense RNA and control 3'2'-cGAMP signaling in Drosophila. Nature. PMID 34261127 DOI: 10.1038/s41586-021-03743-5  0.365
2021 Zhou W, Mohr L, Maciejowski J, Kranzusch PJ. cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing. Molecular Cell. 81: 739-755.e7. PMID 33606975 DOI: 10.1016/j.molcel.2021.01.024  0.317
2020 Eaglesham JB, McCarty KL, Kranzusch PJ. Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict. Elife. 9. PMID 33191912 DOI: 10.7554/eLife.59753  0.355
2020 Morehouse BR, Govande AA, Millman A, Keszei AFA, Lowey B, Ofir G, Shao S, Sorek R, Kranzusch PJ. STING cyclic dinucleotide sensing originated in bacteria. Nature. PMID 32877915 DOI: 10.1038/S41586-020-2719-5  0.463
2020 Lowey B, Whiteley AT, Keszei AFA, Morehouse BR, Mathews IT, Antine SP, Cabrera VJ, Kashin D, Niemann P, Jain M, Schwede F, Mekalanos JJ, Shao S, Lee ASY, Kranzusch PJ. CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. PMID 32544385 DOI: 10.1016/J.Cell.2020.05.019  0.452
2020 Eaglesham JB, Kranzusch PJ. Conserved strategies for pathogen evasion of cGAS-STING immunity. Current Opinion in Immunology. 66: 27-34. PMID 32339908 DOI: 10.1016/J.Coi.2020.04.002  0.492
2020 Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD. Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Molecular Cell. PMID 31932164 DOI: 10.1016/J.Molcel.2019.12.010  0.667
2020 Wade JT, Kranzusch PJ, Sashital DG. Decision letter: Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage Elife. DOI: 10.7554/Elife.57627.Sa1  0.603
2019 Kranzusch PJ. cGAS and CD-NTase enzymes: structure, mechanism, and evolution. Current Opinion in Structural Biology. 59: 178-187. PMID 31593902 DOI: 10.1016/J.Sbi.2019.08.003  0.404
2019 Zhou W, Whiteley AT, Kranzusch PJ. Analysis of human cGAS activity and structure. Methods in Enzymology. 625: 13-40. PMID 31455523 DOI: 10.1016/Bs.Mie.2019.04.012  0.512
2019 de Oliveira Mann CC, Orzalli MH, King DS, Kagan JC, Lee ASY, Kranzusch PJ. Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation. Cell Reports. 27: 1165-1175.e5. PMID 31018131 DOI: 10.1016/J.Celrep.2019.03.098  0.409
2019 Hallberg ZF, Chan CH, Wright TA, Kranzusch PJ, Doxzen KW, Park JJ, Bond DR, Hammond MC. Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration. Elife. 8. PMID 30964001 DOI: 10.7554/Elife.43959  0.389
2019 Barnett KC, Coronas-Serna JM, Zhou W, Ernandes MJ, Cao A, Kranzusch PJ, Kagan JC. Phosphoinositide Interactions Position cGAS at the Plasma Membrane to Ensure Efficient Distinction between Self- and Viral DNA. Cell. PMID 30827685 DOI: 10.1016/J.Cell.2019.01.049  0.433
2019 Whiteley AT, Eaglesham JB, de Oliveira Mann CC, Morehouse BR, Lowey B, Nieminen EA, Danilchanka O, King DS, Lee ASY, Mekalanos JJ, Kranzusch PJ. Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. PMID 30787435 DOI: 10.1038/S41586-019-0953-5  0.383
2019 Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ. Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature. PMID 30728498 DOI: 10.1038/S41586-019-0928-6  0.471
2019 Carey CM, Govande AA, Cooper JM, Hartley MK, Kranzusch PJ, Elde NC. Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates. Cell Host & Microbe. PMID 30713099 DOI: 10.1016/J.Chom.2019.01.001  0.359
2019 Hallberg ZF, Chan CH, Wright TA, Kranzusch PJ, Doxzen KW, Park JJ, Bond DR, Hammond MC. Author response: Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration Elife. DOI: 10.7554/Elife.43959.036  0.3
2019 Mann CCdO, King DS, Kranzusch PJ. Abstract B150: STING acquired species-specific motifs to control alternative immune responses Cancer Immunology Research. 7. DOI: 10.1158/2326-6074.Cricimteatiaacr18-B150  0.433
2018 Zhou W, Whiteley AT, de Oliveira Mann CC, Morehouse BR, Nowak RP, Fischer ES, Gray NS, Mekalanos JJ, Kranzusch PJ. Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 174: 300-311.e11. PMID 30007416 DOI: 10.1016/J.Cell.2018.06.026  0.498
2017 de Oliveira Mann CC, Kranzusch PJ. cGAS Conducts Micronuclei DNA Surveillance. Trends in Cell Biology. PMID 28882413 DOI: 10.1016/J.Tcb.2017.08.007  0.43
2017 Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell. PMID 28844692 DOI: 10.1016/J.Cell.2017.07.037  0.735
2016 Lee AS, Kranzusch PJ, Doudna JA, Cate JH. eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation. Nature. 536: 96-9. PMID 27462815 DOI: 10.1038/Nature18954  0.661
2016 Kaya E, Doxzen KW, Knoll KR, Wilson RC, Strutt SC, Kranzusch PJ, Doudna JA. A bacterial Argonaute with noncanonical guide RNA specificity. Proceedings of the National Academy of Sciences of the United States of America. 113: 4057-62. PMID 27035975 DOI: 10.1073/Pnas.1524385113  0.593
2015 Nuñez JK, Harrington LB, Kranzusch PJ, Engelman AN, Doudna JA. Foreign DNA capture during CRISPR-Cas adaptive immunity. Nature. 527: 535-8. PMID 26503043 DOI: 10.1038/Nature15760  0.746
2015 Kranzusch PJ, Wilson SC, Lee AS, Berger JM, Doudna JA, Vance RE. Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling. Molecular Cell. 59: 891-903. PMID 26300263 DOI: 10.1016/J.Molcel.2015.07.022  0.672
2015 Lee AS, Kranzusch PJ, Cate JH. eIF3 targets cell-proliferation messenger RNAs for translational activation or repression. Nature. 522: 111-4. PMID 25849773 DOI: 10.1038/Nature14267  0.609
2014 Kranzusch PJ, Lee AS, Wilson SC, Solovykh MS, Vance RE, Berger JM, Doudna JA. Structure-guided reprogramming of human cGAS dinucleotide linkage specificity. Cell. 158: 1011-21. PMID 25131990 DOI: 10.1016/J.Cell.2014.07.028  0.7
2014 Nuñez JK, Kranzusch PJ, Noeske J, Wright AV, Davies CW, Doudna JA. Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity. Nature Structural & Molecular Biology. 21: 528-34. PMID 24793649 DOI: 10.1038/Nsmb.2820  0.74
2013 Kranzusch PJ, Vance RE. cGAS dimerization entangles DNA recognition. Immunity. 39: 992-4. PMID 24332024 DOI: 10.1016/J.Immuni.2013.11.012  0.43
2013 Kranzusch PJ, Lee AS, Berger JM, Doudna JA. Structure of human cGAS reveals a conserved family of second-messenger enzymes in innate immunity. Cell Reports. 3: 1362-8. PMID 23707061 DOI: 10.1016/J.Celrep.2013.05.008  0.696
2013 Morin B, Kranzusch PJ, Rahmeh AA, Whelan SPJ. The polymerase of negative-stranded RNA viruses Current Opinion in Virology. 3: 103-110. PMID 23602472 DOI: 10.1016/J.Coviro.2013.03.008  0.301
2012 Kranzusch PJ, Whelan SPJ. Architecture and regulation of negative-strand viral enzymatic machinery Rna Biology. 9: 941-948. PMID 22767259 DOI: 10.4161/Rna.20345  0.361
2011 Kranzusch PJ, Whelan SPJ. Arenavirus Z protein controls viral RNA synthesis by locking a polymerase-promoter complex Proceedings of the National Academy of Sciences of the United States of America. 108: 19743-19748. PMID 22106304 DOI: 10.1073/Pnas.1112742108  0.385
2011 Carette JE, Raaben M, Wong AC, Herbert AS, Obernosterer G, Mulherkar N, Kuehne AI, Kranzusch PJ, Griffin AM, Ruthel G, Dal Cin P, Dye JM, Whelan SP, Chandran K, Brummelkamp TR. Ebola virus entry requires the cholesterol transporter Niemann-Pick C1. Nature. 477: 340-3. PMID 21866103 DOI: 10.1038/Nature10348  0.307
2010 Rahmeh AA, Schenk AD, Danek EI, Kranzusch PJ, Liang B, Walz T, Whelan SP. Molecular architecture of the vesicular stomatitis virus RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America. 107: 20075-80. PMID 21041632 DOI: 10.1073/Pnas.1013559107  0.365
2010 Kranzusch PJ, Schenk AD, Rahmeh AA, Radoshitzky SR, Bavari S, Walz T, Whelan SP. Assembly of a functional Machupo virus polymerase complex. Proceedings of the National Academy of Sciences of the United States of America. 107: 20069-74. PMID 20978208 DOI: 10.1073/Pnas.1007152107  0.36
2010 Liu W, Li Y, Learn GH, Rudicell RS, Robertson JD, Keele BF, Ndjango JB, Sanz CM, Morgan DB, Locatelli S, Gonder MK, Kranzusch PJ, Walsh PD, Delaporte E, Mpoudi-Ngole E, et al. Origin of the human malaria parasite Plasmodium falciparum in gorillas. Nature. 467: 420-5. PMID 20864995 DOI: 10.1038/Nature09442  0.306
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