Kellie R. Machlus, Ph.D. - Publications

Affiliations: 
2011 Pathology University of North Carolina, Chapel Hill, Chapel Hill, NC 
Area:
Physiology Biology, Biochemistry, Medicine and Surgery, Pathology

55 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Desai C, Koupenova M, Machlus KR, Sen Gupta A. Beyond the thrombus: Platelet-inspired nanomedicine approaches in inflammation, immune response, and cancer. Journal of Thrombosis and Haemostasis : Jth. PMID 35441793 DOI: 10.1111/jth.15733  0.313
2021 Chang WC, Jackson JW, Machlus KR, Wolberg AS, Ovanesov MV. Fluorescence artifact correction in the thrombin generation assay: Necessity for correction algorithms in procoagulant samples. Research and Practice in Thrombosis and Haemostasis. 5: 447-455. PMID 33870030 DOI: 10.1002/rth2.12499  0.473
2020 Puhm F, Boilard E, Machlus KR. Platelet Extracellular Vesicles: Beyond the Blood. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314644. PMID 33028092 DOI: 10.1161/ATVBAHA.120.314644  0.346
2020 Chang WC, Jackson JW, Machlus KR, Wolberg AS, Ovanesov MV. Comparative Analysis of Thrombin Calibration Algorithms and Correction for Thrombin-α2macroglobulin Activity. Journal of Clinical Medicine. 9. PMID 32987791 DOI: 10.3390/jcm9103077  0.476
2020 Cushman M, Barnes GD, Creager MA, Diaz JA, Henke PK, Machlus KR, Nieman MT, Wolberg AS. Venous Thromboembolism Research Priorities: A Scientific Statement From the American Heart Association and the International Society on Thrombosis and Haemostasis. Circulation. 142: e85-e94. PMID 32776842 DOI: 10.1161/Cir.0000000000000818  0.525
2020 Melki I, Allaeys I, Tessandier N, Mailhot B, Cloutier N, Campbell RA, Rowley JW, Salem D, Zufferey A, Laroche A, Lévesque T, Patey N, Rauch J, Lood C, Droit A, ... ... Machlus KR, et al. FcγRIIA expression aggravates nephritis and increases platelet activation in systemic lupus erythematosus in mice. Blood. PMID 32766888 DOI: 10.1182/Blood.2020004974  0.398
2020 Cushman M, Barnes GD, Creager MA, Diaz JA, Henke PK, Machlus KR, Nieman MT, Wolberg AS. Venous thromboembolism research priorities: A scientific statement from the American Heart Association and the International Society on Thrombosis and Haemostasis. Research and Practice in Thrombosis and Haemostasis. 4: 714-721. PMID 32685877 DOI: 10.1002/rth2.12373  0.478
2020 French SL, Vijey P, Karhohs KW, Wilkie AR, Horin LJ, Ray A, Posorske B, Carpenter AE, Machlus KR, Italiano JE. High Content, Label-Free Analysis of Proplatelet Production from Megakaryocytes. Journal of Thrombosis and Haemostasis : Jth. PMID 32662223 DOI: 10.1111/Jth.15012  0.429
2020 French SL, Butov KR, Allaeys I, Canas J, Morad G, Davenport P, Laroche A, Trubina NM, Italiano JE, Moses MA, Sola-Visner M, Boilard E, Panteleev MA, Machlus KR. Platelet-derived extracellular vesicles infiltrate and modify the bone marrow during inflammation. Blood Advances. 4: 3011-3023. PMID 32614966 DOI: 10.1182/Bloodadvances.2020001758  0.441
2019 Asquith NL, Machlus KR. Teamwork makes the dream work in thrombopoiesis. Blood. 134: 791-792. PMID 31488457 DOI: 10.1182/Blood.2019002306  0.362
2019 Couldwell G, Machlus KR. Modulation of megakaryopoiesis and platelet production during inflammation. Thrombosis Research. 179: 114-120. PMID 31128560 DOI: 10.1016/J.Thromres.2019.05.008  0.448
2019 Noetzli LJ, French SL, Machlus KR. New Insights Into the Differentiation of Megakaryocytes From Hematopoietic Progenitors. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA119312129. PMID 31043076 DOI: 10.1161/Atvbaha.119.312129  0.345
2019 Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Wactor A, Nelson-Maney N, Morris A, Guo L, Weyrich A, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets. Elife. 8. PMID 31042146 DOI: 10.7554/Elife.44031  0.375
2019 Johnson KE, Ceglowski JR, Roweth HG, Forward JA, Tippy MD, El-Husayni S, Kulenthirarajan R, Malloy MW, Machlus KR, Chen WY, Italiano JE, Battinelli EM. Aspirin inhibits platelets from reprogramming breast tumor cells and promoting metastasis. Blood Advances. 3: 198-211. PMID 30670536 DOI: 10.1182/Bloodadvances.2018026161  0.36
2019 Cunin P, Bouslama R, Machlus KR, Martínez-Bonet M, Lee PY, Wactor A, Nelson-Maney N, Morris A, Guo L, Weyrich A, Sola-Visner M, Boilard E, Italiano JE, Nigrovic PA. Author response: Megakaryocyte emperipolesis mediates membrane transfer from intracytoplasmic neutrophils to platelets Elife. DOI: 10.7554/Elife.44031.026  0.328
2019 Wilkie AR, Noetzli LJ, Couldwell G, Sciaudone AR, Ray A, Machlus KR, Italiano JE. KIFC1 Mediates Centrosome Clustering Prior to Proplatelet Formation from Megakaryocytes Blood. 134: 721-721. DOI: 10.1182/Blood-2019-130803  0.433
2018 Vijey P, Posorske B, Machlus KR. In vitro culture of murine megakaryocytes from fetal liver-derived hematopoietic stem cells. Platelets. 1-6. PMID 30047825 DOI: 10.1080/09537104.2018.1492107  0.367
2018 Roweth HG, Parvin S, Machlus KR. Megakaryocyte modification of platelets in thrombocytopenia. Current Opinion in Hematology. PMID 29985173 DOI: 10.1097/Moh.0000000000000451  0.446
2018 Fager AM, Machlus KR, Ezban M, Hoffman M. Human platelets express Endothelial Protein C Receptor which can be utilized to enhance localization of Factor VIIa activity. Journal of Thrombosis and Haemostasis : Jth. PMID 29879294 DOI: 10.1111/Jth.14165  0.42
2018 Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, et al. Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration. Proceedings of the National Academy of Sciences of the United States of America. PMID 29386381 DOI: 10.1073/Pnas.1720553115  0.425
2018 Noetzli L, Parvin S, Battinelli E, Machlus K. CCL5 Enhances Megakaryocyte Differentiation and Development Blood. 132: 522-522. DOI: 10.1182/Blood-2018-99-117518  0.396
2017 Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE, Weyrich AS, Bear JE, et al. Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood Advances. 1: 1398-1408. PMID 29104956 DOI: 10.1182/Bloodadvances.2017006973  0.415
2017 Machlus KR, Wu SK, Vijey P, Soussou TS, Liu ZJ, Shacham E, Unger TJ, Kashyap T, Klebanov B, Sola-Visner M, Crochiere M, Italiano JE, Landesman Y. Selinexor-induced thrombocytopenia results from inhibition of thrombopoietin signaling in early megakaryopoiesis. Blood. PMID 28630120 DOI: 10.1182/Blood-2016-11-752840  0.314
2017 Machlus KR, Battinelli EM. RBCs pin platelets against the (thrombus) wall. Blood. 129: 2460-2461. PMID 28473411 DOI: 10.1182/Blood-2017-03-772079  0.457
2017 Johnson KE, Forward JA, Tippy MD, Ceglowski JR, El-Husayni S, Kulenthirarajan R, Machlus KR, Mayer EL, Italiano JE, Battinelli EM. Tamoxifen Directly Inhibits Platelet Angiogenic Potential and Platelet-Mediated Metastasis. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 28153880 DOI: 10.1161/Atvbaha.116.308791  0.398
2016 Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE. Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood. PMID 26744461 DOI: 10.1182/Blood-2015-08-663146  0.363
2016 Johnson KE, Machlus KR, Forward JA, Tippy MD, El-Husayni SA, Italiano JE, Battinelli EM. Abstract C12: Platelets promote breast cancer metastasis by reprogramming tumor cells to produce IL-8 Cancer Research. 76. DOI: 10.1158/1538-7445.Tme16-C12  0.356
2015 Machlus KR, Johnson KE, Kulenthirarajan R, Forward JA, Tippy MD, Soussou TS, El-Husayni SH, Wu SK, Wang S, Watnick RS, Italiano JE, Battinelli EM. CCL5 derived from platelets increases megakaryocyte proplatelet formation. Blood. PMID 26647394 DOI: 10.1182/Blood-2015-05-644583  0.437
2015 Barbieri SS, Petrucci G, Tarantino E, Amadio P, Rocca B, Pesce M, Machlus KR, Ranelletti FO, Gianellini S, Weksler B, Italiano JE, Tremoli E. Abnormal megakaryopoiesis and platelet function in cyclooxygenase-2-deficient mice. Thrombosis and Haemostasis. 114: 1218-29. PMID 26272103 DOI: 10.1160/Th14-10-0872  0.437
2015 Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, et al. Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. The Journal of Clinical Investigation. 125: 2369-74. PMID 25961454 DOI: 10.1172/Jci77670  0.386
2015 Johnson KE, Machlus KR, El-Husayni S, Kulenthirarajan R, Forward JA, Italiano JE, Battinelli EM. Platelets Promote Breast Cancer Metastasis By Reprogramming Tumor Cells to Produce IL-8 Blood. 126: 2233-2233. DOI: 10.1182/Blood.V126.23.2233.2233  0.362
2015 Machlus KR, Johnson KE, Kulenthirarajan R, El-Husayni S, Forward JA, Wu SK, Italiano JE, Battinelli EM. CCL5 Released from Platelets Increases Megakaryocyte Maturation and Proplatelet Formation Blood. 126: 1162-1162. DOI: 10.1182/Blood.V126.23.1162.1162  0.435
2014 Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE. Platelet bioreactor-on-a-chip. Blood. 124: 1857-67. PMID 25606631 DOI: 10.1182/Blood-2014-05-574913  0.416
2014 Feng Q, Shabrani N, Thon JN, Huo H, Thiel A, Machlus KR, Kim K, Brooks J, Li F, Luo C, Kimbrel EA, Wang J, Kim KS, Italiano J, Cho J, et al. Scalable generation of universal platelets from human induced pluripotent stem cells. Stem Cell Reports. 3: 817-31. PMID 25418726 DOI: 10.1016/J.Stemcr.2014.09.010  0.44
2014 Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE, et al. Proteasome function is required for platelet production. The Journal of Clinical Investigation. 124: 3757-66. PMID 25061876 DOI: 10.1172/Jci75247  0.395
2014 Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE. Platelet bioreactor-on-a-chip. Blood. PMID 25049277 DOI: 10.1182/blood-2014-05-574913  0.311
2014 Machlus KR, Thon JN, Italiano JE. Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation. British Journal of Haematology. 165: 227-36. PMID 24499183 DOI: 10.1111/Bjh.12758  0.448
2014 Battinelli EM, Markens BA, Kulenthirarajan RA, Machlus KR, Flaumenhaft R, Italiano JE. Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response. Blood. 123: 101-12. PMID 24065244 DOI: 10.1182/Blood-2013-02-485011  0.438
2014 Noh J, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan S, Chou ST, Paralkar VR, Machlus KR, Italiano JE, Kyba M, French DL, Poncz M, Weiss MJ. Inducible Gata1 Suppression As a Novel Strategy to Expand Physiologic Megakaryocyte Production from Embryonic Stem Cells Blood. 124: 3846-3846. DOI: 10.1182/Blood.V124.21.3846.3846  0.384
2014 Machlus KR, Wu S, Carlson R, Friedlander S, Kashyap T, Kalid O, Shacham E, Rashal T, Shacham S, Italiano JE, Landesman Y. Selinexor-Induced Thrombocytopenia Results from the Inhibition of Megakaryocyte Progenitor Cells in the Early Stage of Megakaryopoiesis Blood. 124: 1458-1458. DOI: 10.1182/Blood.V124.21.1458.1458  0.419
2013 Machlus KR, Italiano JE. The incredible journey: From megakaryocyte development to platelet formation. The Journal of Cell Biology. 201: 785-96. PMID 23751492 DOI: 10.1083/Jcb.201304054  0.447
2013 Aleman MM, Walton BL, Byrnes JR, Wang JG, Heisler MJ, Machlus KR, Cooley BC, Wolberg AS. Elevated prothrombin promotes venous, but not arterial, thrombosis in mice Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 1829-1836. PMID 23723374 DOI: 10.1161/Atvbaha.113.301607  0.577
2013 Battinelli EM, Markens BA, Kulenthirarajan R, Machlus KR, Flaumenhaft R, Italiano JE. Anticoagulation Inhibits Tumor Cell-Mediated Release Of Platelet Angiogenic Proteins and Disrupts The Platelet Angiogenic Potential Blood. 122: 2303-2303. DOI: 10.1182/Blood.V122.21.2303.2303  0.437
2012 Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Weyrich AS, Semple JW, Flaumenhaft R, Italiano JE. T granules in human platelets function in TLR9 organization and signaling. The Journal of Cell Biology. 198: 561-74. PMID 22908309 DOI: 10.1083/Jcb.201111136  0.31
2012 Wolberg AS, Aleman MM, Leiderman K, Machlus KR. Procoagulant activity in hemostasis and thrombosis: Virchow's triad revisited. Anesthesia and Analgesia. 114: 275-85. PMID 22104070 DOI: 10.1213/Ane.0B013E31823A088C  0.609
2012 Machlus KR, Shi D, Weyrich AS, Italiano JE. Protein Synthesis and Degradation in the Late Stages of Megakaryocyte Maturation Trigger Proplatelet Formation Blood. 120: 1218-1218. DOI: 10.1182/Blood.V120.21.1218.1218  0.385
2012 Liu X, Mu J, Machlus KR, Wolberg AS, Rosen ED, Xu Z, Alber MS, Chen DZ. Automatic segmentation and analysis of fibrin networks in 3D confocal microscopy images Progress in Biomedical Optics and Imaging - Proceedings of Spie. 8314. DOI: 10.1117/12.911712  0.504
2011 Machlus KR, Lin FC, Wolberg AS. Procoagulant activity induced by vascular injury determines contribution of elevated factor VIII to thrombosis and thrombus stability in mice. Blood. 118: 3960-8. PMID 21828144 DOI: 10.1182/Blood-2011-06-362814  0.562
2011 Gray LD, Hussey MA, Larson BM, MacHlus KR, Campbell RA, Koch G, Ezban M, Hedner U, Wolberg AS. Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma Thrombosis Research. 128: 570-576. PMID 21561645 DOI: 10.1016/J.Thromres.2011.04.009  0.589
2011 Machlus KR, Cardenas JC, Church FC, Wolberg AS. Causal relationship between hyperfibrinogenemia, thrombosis, and resistance to thrombolysis in mice. Blood. 117: 4953-63. PMID 21355090 DOI: 10.1182/Blood-2010-11-316885  0.603
2011 Machlus KR, Aleman MM, Wolberg AS. Update on venous thromboembolism: risk factors, mechanisms, and treatments. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 476-8. PMID 21325668 DOI: 10.1161/Atvbaha.111.223008  0.515
2011 Kim E, Kim OV, MacHlus KR, Liu X, Kupaev T, Lioi J, Wolberg AS, Chen DZ, Rosen ED, Xu Z, Alber M. Correlation between fibrin network structure and mechanical properties: An experimental and computational analysis Soft Matter. 7: 4983-4992. DOI: 10.1039/C0Sm01528H  0.503
2010 Campbell RA, MacHlus KR, Wolberg AS. Editorial: Smoking out the cause of thrombosis Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 7-8. PMID 20018940 DOI: 10.1161/Atvbaha.109.198051  0.555
2010 Ollivier V, Wang J, Manly D, Machlus KR, Wolberg AS, Jandrot-Perrus M, Mackman N. Detection of endogenous tissue factor levels in plasma using the calibrated automated thrombogram assay. Thrombosis Research. 125: 90-6. PMID 19345399 DOI: 10.1016/J.Thromres.2009.03.003  0.552
2009 Machlus KR, Colby EA, Wu JR, Koch GG, Key NS, Wolberg AS. Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram. Thrombosis and Haemostasis. 102: 936-44. PMID 19888532 DOI: 10.1160/Th09-03-0180  0.607
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