| Year |
Citation |
Score |
| 2023 |
Thoden JB, McKnight JO, Kroft CW, Jast JDT, Holden HM. Structural analysis of a bacterial UDP-sugar 2-epimerase reveals the active site architecture before and after catalysis. The Journal of Biological Chemistry. 105200. PMID 37660908 DOI: 10.1016/j.jbc.2023.105200 |
0.432 |
|
| 2023 |
Hofmeister DL, Seltzner CA, Bockhaus NJ, Thoden JB, Holden HM. Investigation of the enzymes required for the biosynthesis of 2,3-diacetamido-2,3-dideoxy-d-glucuronic acid in Psychrobacter cryohalolentis K5. Protein Science : a Publication of the Protein Society. 32: e4502. PMID 36346293 DOI: 10.1002/pro.4502 |
0.395 |
|
| 2022 |
Xiang DF, Thoden JB, Ghosh MK, Holden HM, Raushel FM. Reaction Mechanism and Three-Dimensional Structure of GDP-d-glycero-α-d-manno-heptose 4,6-Dehydratase from . Biochemistry. PMID 35715226 DOI: 10.1021/acs.biochem.2c00244 |
0.349 |
|
| 2022 |
Herkert NR, Thoden JB, Holden HM. Structure and Function of an N-acetyltransferase from the Human Pathogen Acinetobacter baumannii Isolate BAL_212. Proteins. PMID 35277885 DOI: 10.1002/prot.26334 |
0.407 |
|
| 2021 |
Griffiths WA, Spencer KD, Thoden JB, Holden HM. Biochemical Investigation of an N-acetyltransferase from Helicobacter pullorum. Protein Science : a Publication of the Protein Society. PMID 34651380 DOI: 10.1002/pro.4207 |
0.37 |
|
| 2021 |
Seltzner CA, Ferek JD, Thoden JB, Holden HM. Characterization of an aminotransferase from Acanthamoeba polyphaga Mimivirus. Protein Science : a Publication of the Protein Society. PMID 34076307 DOI: 10.1002/pro.4139 |
0.41 |
|
| 2021 |
Linehan MP, Thoden JB, Holden HM. Characterization of two enzymes from Psychrobacter cryohalolentis that are required for the biosynthesis of an unusual diacetamido-d-sugar. The Journal of Biological Chemistry. 100463. PMID 33639157 DOI: 10.1016/j.jbc.2021.100463 |
0.433 |
|
| 2020 |
Bockhaus NJ, Ferek JD, Thoden JB, Holden HM. The High-Resolution Structure of a UDP-l-Rhamnose Synthase from Acanthamoeba polyphaga Mimivirus. Protein Science : a Publication of the Protein Society. PMID 32797646 DOI: 10.1002/Pro.3928 |
0.481 |
|
| 2020 |
Huddleston JP, Anderson TK, Spencer KD, Thoden JB, Raushel FM, Holden HM. Structural Analysis of Cj1427, an Essential NAD-dependent Dehydrogenase for the Biosynthesis of the Heptose Residues in the Capsular Polysaccharides of Campylobacter jejuni. Biochemistry. PMID 32168450 DOI: 10.1021/Acs.Biochem.0C00096 |
0.465 |
|
| 2020 |
Ferek JD, Thoden JB, Holden HM. Biochemical analysis of a sugar 4,6-dehydratase from Acanthamoeba polyphaga Mimivirus. Protein Science : a Publication of the Protein Society. PMID 32083779 DOI: 10.1002/Pro.3843 |
0.492 |
|
| 2019 |
Girardi NM, Thoden JB, Holden HM. Misannotations of the Genes Encoding Sugar N-formyltransferases. Protein Science : a Publication of the Protein Society. PMID 31867814 DOI: 10.1002/Pro.3807 |
0.457 |
|
| 2019 |
Huddleston JP, Thoden JB, Dopkins BJ, Narindoshvili T, Fose BJ, Holden HM, Raushel FM. Structural and Functional Characterization of YdjI, an Aldolase of Unknown Specificity in Escherichia coli K12. Biochemistry. PMID 31322866 DOI: 10.1021/Acs.Biochem.9B00326 |
0.423 |
|
| 2019 |
Hofmeister DL, Thoden JB, Holden HM. Investigation of a Sugar N-formyltransferase from the Plant Pathogen Pantoea ananatis. Protein Science : a Publication of the Protein Society. PMID 30666752 DOI: 10.1002/Pro.3577 |
0.39 |
|
| 2018 |
Vrielink A, Holden HM. Editorial overview: Catalysis and regulation: Structural features guiding enzyme catalysed processes. Current Opinion in Structural Biology. 53: iii-v. PMID 30553296 DOI: 10.1016/J.Sbi.2018.11.008 |
0.415 |
|
| 2018 |
Brown HA, Vinogradov E, Gilbert M, Holden HM. The Mycobacterium tuberculosis Complex has a Pathway for the Biosynthesis of 4-Formamido-4,6-Dideoxy-d-Glucose. Protein Science : a Publication of the Protein Society. PMID 29761597 DOI: 10.1002/Pro.3443 |
0.363 |
|
| 2018 |
Dow GT, Thoden JB, Holden HM. The Three-Dimensional Structure of NeoB: An Aminotransferase Involved in the Biosynthesis of Neomycin. Protein Science : a Publication of the Protein Society. PMID 29516565 DOI: 10.1002/Pro.3400 |
0.472 |
|
| 2017 |
Grisewood MJ, Hernandez Lozada NJ, Thoden JB, Gifford NP, Mendez-Perez D, Schoenberger HA, Allan MF, Floy ME, Lai RY, Holden HM, Pfleger BF, Maranas CD. Computational Redesign of Acyl-ACP Thioesterase with Improved Selectivity toward Medium-Chain-Length Fatty Acids. Acs Catalysis. 7: 3837-3849. PMID 29375928 DOI: 10.1021/Acscatal.7B00408 |
0.439 |
|
| 2017 |
Delvaux NA, Thoden JB, Holden HM. Molecular Architectures of Pen and Pal: Key Enzymes Required for CMP-Pseudaminic Acid Biosynthesis in Bacillus thuringiensis. Protein Science : a Publication of the Protein Society. PMID 29266550 DOI: 10.1002/Pro.3368 |
0.562 |
|
| 2017 |
Brown HA, Thoden JB, Tipton PA, Holden HM. The Structure of Glucose-1-Phosphate Thymidylyltransferase from Mycobacterium tuberculosis Reveals the Location of an Essential Magnesium Ion in the RmlA-type Enzymes. Protein Science : a Publication of the Protein Society. PMID 29076563 DOI: 10.1002/Pro.3333 |
0.43 |
|
| 2017 |
Riegert AS, Thoden JB, Schoenhofen IC, Watson DC, Young NM, Tipton PA, Holden HM. Structural and Biochemical Investigation of PglF from Campylobacter jejuni Reveals a New Mechanism for a Member of the Short Chain Dehydrogenase/Reductase Superfamily. Biochemistry. PMID 29053280 DOI: 10.1021/Acs.Biochem.7B00910 |
0.559 |
|
| 2017 |
Taylor Z, Brown HA, Holden HM, Raushel FM. Biosynthesis of Nucleoside Diphosphoramidates in Campylobacter jejuni. Biochemistry. PMID 29023101 DOI: 10.1021/Acs.Biochem.7B00905 |
0.405 |
|
| 2017 |
Zachman-Brockmeyer TR, Thoden JB, Holden HM. The Structure of RbmB from Streptomyces ribosidificus, an Aminotransferase Involved in the Biosynthesis of Ribostamycin. Protein Science : a Publication of the Protein Society. PMID 28685903 DOI: 10.1002/Pro.3221 |
0.516 |
|
| 2017 |
Dunsirn MM, Thoden JB, Gilbert M, Holden HM. Biochemical Investigation of Rv3404c from Mycobacterium tuberculosis. Biochemistry. PMID 28665588 DOI: 10.1021/Acs.Biochem.7B00506 |
0.348 |
|
| 2017 |
Taylor ZW, Brown HA, Narindoshvili T, Wenzel CQ, Szymanski C, Holden HM, Raushel FM. Discovery of a Glutamine Kinase Required for the Biosynthesis of the O-Methyl Phosphoramidate Modifications Found in the Capsular Polysaccharides of Campylobacter jejuni. Journal of the American Chemical Society. PMID 28650156 DOI: 10.1021/Jacs.7B04824 |
0.418 |
|
| 2017 |
Riegert AS, Chantigian DP, Thoden JB, Tipton PA, Holden HM. Biochemical Characterization of WbkC, an N-formyltransferase from Brucella melitensis. Biochemistry. PMID 28636341 DOI: 10.1021/Acs.Biochem.7B00494 |
0.529 |
|
| 2017 |
Woodford CR, Thoden JB, Holden HM. Molecular Architecture of an N-formyltransferase from Salmonella enterica O60. Journal of Structural Biology. PMID 28263875 DOI: 10.1016/J.Jsb.2017.03.002 |
0.478 |
|
| 2017 |
Li ZZ, Riegert AS, Goneau MF, Cunningham AM, Vinogradov E, Li J, Schoenhofen IC, Thoden JB, Holden HM, Gilbert M. Characterization of the dTDP-Fuc3N and dTDP-Qui3N biosynthetic pathways in Campylobacter jejuni 81116†. Glycobiology. PMID 28096310 DOI: 10.1093/Glycob/Cww136 |
0.515 |
|
| 2016 |
Dow GT, Gilbert M, Thoden JB, Holden HM. Structural Investigation on WlaRG from Campylobacter jejuni: A Sugar Aminotransferase. Protein Science : a Publication of the Protein Society. PMID 28028852 DOI: 10.1002/Pro.3109 |
0.473 |
|
| 2016 |
Dow GT, Thoden JB, Holden HM. Structural Studies on KijD1, a Sugar C-3'-Methyltransferase. Protein Science : a Publication of the Protein Society. PMID 27595766 DOI: 10.1002/Pro.3034 |
0.547 |
|
| 2016 |
Salinger AJ, Thoden JB, Holden HM. Structural and Functional Investigation of FdhC from Acinetobacter nosocomialis: a Sugar N-Acyltransferase Belonging to the GNAT Superfamily. Biochemistry. PMID 27404806 DOI: 10.1021/Acs.Biochem.6B00602 |
0.551 |
|
| 2016 |
Dopkins BJ, Tipton PA, Thoden JB, Holden HM. Structural Studies on a Glucosamine/Glucosaminide N-Acetyltransferase. Biochemistry. PMID 27348258 DOI: 10.1021/Acs.Biochem.6B00536 |
0.557 |
|
| 2016 |
Zachman-Brockmeyer TR, Thoden JB, Holden HM. Structures of KdnB and KdnA from Shewanella oneidensis: Key Enzymes in the Formation of 8-Amino-3,8-Dideoxy-D-Manno-Octulosonic Acid. Biochemistry. PMID 27275764 DOI: 10.1021/Acs.Biochem.6B00439 |
0.523 |
|
| 2016 |
Holden HM, Thoden JB, Gilbert M. Enzymes required for the biosynthesis of N-formylated sugars. Current Opinion in Structural Biology. 41: 1-9. PMID 27209114 DOI: 10.1016/J.Sbi.2016.04.003 |
0.375 |
|
| 2016 |
Genthe NA, Thoden JB, Holden HM. Structure of the Escherichia coli ArnA N-Formyltransferase Domain in Complex with N(5) -formyltetrahydrofolate and UDP-Ara4N. Protein Science : a Publication of the Protein Society. PMID 27171345 DOI: 10.1002/Pro.2938 |
0.424 |
|
| 2015 |
Riegert AS, Young NM, Watson DC, Thoden JB, Holden HM. Structure of the external aldimine form of PglE, an aminotransferase required for N,N'-diacetylbacillosamine biosynthesis. Protein Science : a Publication of the Protein Society. 24: 1609-16. PMID 26178292 DOI: 10.1002/Pro.2745 |
0.487 |
|
| 2015 |
Delvaux NA, Thoden JB, Holden HM. Molecular architecture of KedS8, a sugar N-methyltransferase from Streptoalloteichus sp. ATCC 53650. Protein Science : a Publication of the Protein Society. 24: 1593-9. PMID 26177844 DOI: 10.1002/Pro.2742 |
0.467 |
|
| 2015 |
Salinger AJ, Brown HA, Thoden JB, Holden HM. Biochemical studies on WbcA, a sugar epimerase from Yersinia enterocolitica. Protein Science : a Publication of the Protein Society. 24: 1633-9. PMID 26174084 DOI: 10.1002/Pro.2747 |
0.541 |
|
| 2015 |
Thoden JB, Vinogradov E, Gilbert M, Salinger AJ, Holden HM. Bacterial Sugar 3,4-Ketoisomerases: Structural Insight into Product Stereochemistry. Biochemistry. 54: 4495-506. PMID 26125548 DOI: 10.1021/Acs.Biochem.5B00541 |
0.559 |
|
| 2015 |
Genthe NA, Thoden JB, Benning MM, Holden HM. Molecular structure of an N-formyltransferase from Providencia alcalifaciens O30. Protein Science : a Publication of the Protein Society. 24: 976-86. PMID 25752909 DOI: 10.1002/Pro.2675 |
0.503 |
|
| 2015 |
Woodford CR, Thoden JB, Holden HM. New role for the ankyrin repeat revealed by a study of the N-formyltransferase from Providencia alcalifaciens. Biochemistry. 54: 631-8. PMID 25574689 DOI: 10.1021/Bi501539A |
0.536 |
|
| 2014 |
Thoden JB, Holden HM, Grant GA. Structure of L-serine dehydratase from Legionella pneumophila: novel use of the C-terminal cysteine as an intrinsic competitive inhibitor. Biochemistry. 53: 7615-24. PMID 25380533 DOI: 10.1021/Bi501253W |
0.465 |
|
| 2014 |
Thoden JB, Holden HM. The molecular architecture of QdtA, a sugar 3,4-ketoisomerase from Thermoanaerobacterium thermosaccharolyticum. Protein Science : a Publication of the Protein Society. 23: 683-92. PMID 24616215 DOI: 10.1002/Pro.2451 |
0.599 |
|
| 2014 |
Thoden JB, Holden HM. Production of a novel N-monomethylated dideoxysugar. Biochemistry. 53: 1105-7. PMID 24512254 DOI: 10.1021/Bi500098A |
0.355 |
|
| 2014 |
Zimmer AL, Thoden JB, Holden HM. Three-dimensional structure of a sugar N-formyltransferase from Francisella tularensis. Protein Science : a Publication of the Protein Society. 23: 273-83. PMID 24347283 DOI: 10.1002/Pro.2409 |
0.568 |
|
| 2013 |
Dunaway-Mariano D, Holden HM, Raushel FM. W. W. "Mo" Cleland: a catalytic life. Biochemistry. 52: 9092-6. PMID 24308306 DOI: 10.1021/Bi4015709 |
0.378 |
|
| 2013 |
Chantigian DP, Thoden JB, Holden HM. Structural and biochemical characterization of a bifunctional ketoisomerase/N-acetyltransferase from Shewanella denitrificans. Biochemistry. 52: 8374-85. PMID 24128043 DOI: 10.1021/Bi401170T |
0.538 |
|
| 2013 |
Thoden JB, Goneau MF, Gilbert M, Holden HM. Structure of a sugar N-formyltransferase from Campylobacter jejuni. Biochemistry. 52: 6114-26. PMID 23898784 DOI: 10.1021/Bi4009006 |
0.54 |
|
| 2013 |
Reinhardt LA, Thoden JB, Peters GS, Holden HM, Cleland WW. pH-rate profiles support a general base mechanism for galactokinase (Lactococcus lactis). Febs Letters. 587: 2876-81. PMID 23872454 DOI: 10.1016/J.Febslet.2013.07.017 |
0.388 |
|
| 2013 |
Thoden JB, Branch MC, Zimmer AL, Bruender NA, Holden HM. Active site architecture of a sugar N-oxygenase. Biochemistry. 52: 3191-3. PMID 23621882 DOI: 10.1021/Bi400407X |
0.798 |
|
| 2013 |
Kubiak RL, Thoden JB, Holden HM. Structure of EvaA: a paradigm for sugar 2,3-dehydratases. Biochemistry. 52: 2078-88. PMID 23473392 DOI: 10.1021/Bi400176N |
0.837 |
|
| 2013 |
Zmudka MW, Thoden JB, Holden HM. The structure of DesR from Streptomyces venezuelae, a β-glucosidase involved in macrolide activation. Protein Science : a Publication of the Protein Society. 22: 883-92. PMID 23225731 DOI: 10.1002/Pro.2204 |
0.492 |
|
| 2012 |
Kubiak RL, Phillips RK, Zmudka MW, Ahn MR, Maka EM, Pyeatt GL, Roggensack SJ, Holden HM. Structural and functional studies on a 3'-epimerase involved in the biosynthesis of dTDP-6-deoxy-D-allose. Biochemistry. 51: 9375-83. PMID 23116432 DOI: 10.1021/Bi3012737 |
0.839 |
|
| 2012 |
Waldrop GL, Holden HM, Maurice MS. The enzymes of biotin dependent CO2 metabolism: What structures reveal about their reaction mechanisms Protein Science. 21: 1597-1619. PMID 22969052 DOI: 10.1002/Pro.2156 |
0.474 |
|
| 2012 |
Song F, Thoden JB, Zhuang Z, Latham J, Trujillo M, Holden HM, Dunaway-Mariano D. The catalytic mechanism of the hotdog-fold enzyme superfamily 4-hydroxybenzoyl-CoA thioesterase from Arthrobacter sp. strain SU. Biochemistry. 51: 7000-16. PMID 22873756 DOI: 10.1021/Bi301059M |
0.52 |
|
| 2012 |
Bruender NA, Holden HM. Probing the catalytic mechanism of a C-3'-methyltransferase involved in the biosynthesis of D-tetronitrose. Protein Science : a Publication of the Protein Society. 21: 876-86. PMID 22495991 DOI: 10.1002/Pro.2074 |
0.826 |
|
| 2012 |
Thoden JB, Reinhardt LA, Cook PD, Menden P, Cleland WW, Holden HM. Catalytic mechanism of perosamine N-acetyltransferase revealed by high-resolution X-ray crystallographic studies and kinetic analyses. Biochemistry. 51: 3433-44. PMID 22443398 DOI: 10.1021/Bi300197H |
0.535 |
|
| 2012 |
Kubiak RL, Holden HM. Structural studies of AntD: an N-Acyltransferase involved in the biosynthesis of D-Anthrose. Biochemistry. 51: 867-78. PMID 22220494 DOI: 10.1021/Bi201650C |
0.844 |
|
| 2011 |
Kubiak RL, Holden HM. Combined structural and functional investigation of a C-3''-ketoreductase involved in the biosynthesis of dTDP-L-digitoxose. Biochemistry. 50: 5905-17. PMID 21598943 DOI: 10.1021/Bi200514B |
0.841 |
|
| 2011 |
Kim A, Benning MM, OkLee S, Quinn J, Martin BM, Holden HM, Dunaway-Mariano D. Divergence of chemical function in the alkaline phosphatase superfamily: structure and mechanism of the P-C bond cleaving enzyme phosphonoacetate hydrolase. Biochemistry. 50: 3481-94. PMID 21366328 DOI: 10.1021/Bi200165H |
0.493 |
|
| 2011 |
Thoden JB, Holden HM. Biochemical and structural characterization of WlbA from Bordetella pertussis and Chromobacterium violaceum: enzymes required for the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid. Biochemistry. 50: 1483-91. PMID 21241053 DOI: 10.1021/Bi101871F |
0.543 |
|
| 2011 |
Carney AE, Holden HM. Molecular architecture of TylM1 from Streptomyces fradiae: an N,N-dimethyltransferase involved in the production of dTDP-D-mycaminose. Biochemistry. 50: 780-7. PMID 21142177 DOI: 10.1021/Bi101733Y |
0.792 |
|
| 2010 |
Holden HM, Cook PD, Thoden JB. Biosynthetic enzymes of unusual microbial sugars. Current Opinion in Structural Biology. 20: 543-50. PMID 20832292 DOI: 10.1016/J.Sbi.2010.08.002 |
0.421 |
|
| 2010 |
Thoden JB, Holden HM. Structural and functional studies of WlbA: A dehydrogenase involved in the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid . Biochemistry. 49: 7939-48. PMID 20690587 DOI: 10.1021/Bi101103S |
0.54 |
|
| 2010 |
Bruender NA, Thoden JB, Kaur M, Avey MK, Holden HM. Molecular architecture of a C-3'-methyltransferase involved in the biosynthesis of D-tetronitrose. Biochemistry. 49: 5891-8. PMID 20527922 DOI: 10.1021/Bi100782B |
0.819 |
|
| 2010 |
Thoden JB, Holden HM. Molecular structure of WlbB, a bacterial N-acetyltransferase involved in the biosynthesis of 2,3-diacetamido-2,3-dideoxy-D-mannuronic acid . Biochemistry. 49: 4644-53. PMID 20433200 DOI: 10.1021/Bi1005738 |
0.531 |
|
| 2010 |
Bruender NA, Thoden JB, Holden HM. X-ray structure of kijd3, a key enzyme involved in the biosynthesis of D-kijanose. Biochemistry. 49: 3517-24. PMID 20334431 DOI: 10.1021/Bi100318V |
0.833 |
|
| 2010 |
Thoden JB, Holden HM, Paritala H, Firestine SM. Structural and functional studies of Aspergillus clavatus N(5)-carboxyaminoimidazole ribonucleotide synthetase . Biochemistry. 49: 752-60. PMID 20050602 DOI: 10.1021/Bi901599U |
0.513 |
|
| 2009 |
Cook PD, Kubiak RL, Toomey DP, Holden HM. Two site-directed mutations are required for the conversion of a sugar dehydratase into an aminotransferase. Biochemistry. 48: 5246-53. PMID 19402712 DOI: 10.1021/Bi9005545 |
0.824 |
|
| 2009 |
Firestine SM, Paritala H, McDonnell JE, Thoden JB, Holden HM. Identification of inhibitors of N5-carboxyaminoimidazole ribonucleotide synthetase by high-throughput screening. Bioorganic & Medicinal Chemistry. 17: 3317-23. PMID 19362848 DOI: 10.1016/J.Bmc.2009.03.043 |
0.323 |
|
| 2009 |
Thoden JB, Cook PD, Schäffer C, Messner P, Holden HM. Structural and functional studies of QdtC: an N-acetyltransferase required for the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose. Biochemistry. 48: 2699-709. PMID 19191736 DOI: 10.1021/Bi802313N |
0.564 |
|
| 2009 |
Thoden JB, Schäffer C, Messner P, Holden HM. Structural analysis of QdtB, an aminotransferase required for the biosynthesis of dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose. Biochemistry. 48: 1553-61. PMID 19178182 DOI: 10.1021/Bi8022015 |
0.547 |
|
| 2008 |
Thoden JB, Holden HM, Firestine SM. Structural analysis of the active site geometry of N5-carboxyaminoimidazole ribonucleotide synthetase from Escherichia coli. Biochemistry. 47: 13346-53. PMID 19053251 DOI: 10.1021/Bi801734Z |
0.481 |
|
| 2008 |
Cook PD, Carney AE, Holden HM. Accommodation of GDP-linked sugars in the active site of GDP-perosamine synthase. Biochemistry. 47: 10685-93. PMID 18795799 DOI: 10.1021/Bi801309Q |
0.781 |
|
| 2008 |
Thoden JB, Ryan LA, Reece RJ, Holden HM. The interaction between an acidic transcriptional activator and its inhibitor. The molecular basis of Gal4p recognition by Gal80p. The Journal of Biological Chemistry. 283: 30266-72. PMID 18701455 DOI: 10.1074/Jbc.M805200200 |
0.448 |
|
| 2008 |
Burgie ES, Holden HM. Three-dimensional structure of DesVI from Streptomyces venezuelae: a sugar N,N-dimethyltransferase required for dTDP-desosamine biosynthesis. Biochemistry. 47: 3982-8. PMID 18327916 DOI: 10.1021/Bi800063J |
0.546 |
|
| 2008 |
Cook PD, Holden HM. GDP-perosamine synthase: structural analysis and production of a novel trideoxysugar. Biochemistry. 47: 2833-40. PMID 18247575 DOI: 10.1021/Bi702430D |
0.553 |
|
| 2008 |
Cook PD, Holden HM. GDP-4-keto-6-deoxy-D-mannose 3-dehydratase, accommodating a sugar substrate in the active site. The Journal of Biological Chemistry. 283: 4295-303. PMID 18045869 DOI: 10.1074/Jbc.M708893200 |
0.539 |
|
| 2007 |
Cook PD, Holden HM. A structural study of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: caught in the act of geminal diamine formation. Biochemistry. 46: 14215-24. PMID 17997582 DOI: 10.1021/Bi701686S |
0.525 |
|
| 2007 |
Burgie ES, Holden HM. Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine. Biochemistry. 46: 8999-9006. PMID 17630700 DOI: 10.1021/Bi700751D |
0.545 |
|
| 2007 |
Thoden JB, Holden HM. Active site geometry of glucose-1-phosphate uridylyltransferase. Protein Science : a Publication of the Protein Society. 16: 1379-88. PMID 17567737 DOI: 10.1110/Ps.072864707 |
0.495 |
|
| 2007 |
Davis ML, Thoden JB, Holden HM. The x-ray structure of dTDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase. The Journal of Biological Chemistry. 282: 19227-36. PMID 17459872 DOI: 10.1074/Jbc.M702529200 |
0.552 |
|
| 2007 |
Burgie ES, Thoden JB, Holden HM. Molecular architecture of DesV from Streptomyces venezuelae: a PLP-dependent transaminase involved in the biosynthesis of the unusual sugar desosamine. Protein Science : a Publication of the Protein Society. 16: 887-96. PMID 17456741 DOI: 10.1110/Ps.062711007 |
0.554 |
|
| 2007 |
Thoden JB, Holden HM. The molecular architecture of glucose-1-phosphate uridylyltransferase. Protein Science : a Publication of the Protein Society. 16: 432-40. PMID 17322528 DOI: 10.1110/Ps.062626007 |
0.437 |
|
| 2007 |
Thoden JB, Sellick CA, Reece RJ, Holden HM. Understanding a transcriptional paradigm at the molecular level. The structure of yeast Gal80p. The Journal of Biological Chemistry. 282: 1534-8. PMID 17121853 DOI: 10.1074/Jbc.C600285200 |
0.453 |
|
| 2006 |
Cook PD, Thoden JB, Holden HM. The structure of GDP-4-keto-6-deoxy-D-mannose-3-dehydratase: a unique coenzyme B6-dependent enzyme. Protein Science : a Publication of the Protein Society. 15: 2093-106. PMID 16943443 DOI: 10.1110/Ps.062328306 |
0.566 |
|
| 2005 |
Martí-Arbona R, Thoden JB, Holden HM, Raushel FM. Functional significance of Glu-77 and Tyr-137 within the active site of isoaspartyl dipeptidase. Bioorganic Chemistry. 33: 448-58. PMID 16289685 DOI: 10.1016/J.Bioorg.2005.10.002 |
0.506 |
|
| 2005 |
Thoden JB, Sellick CA, Timson DJ, Reece RJ, Holden HM. Molecular structure of Saccharomyces cerevisiae Gal1p, a bifunctional galactokinase and transcriptional inducer. The Journal of Biological Chemistry. 280: 36905-11. PMID 16115868 DOI: 10.1074/Jbc.M508446200 |
0.489 |
|
| 2005 |
Thoden JB, Holden HM. The molecular architecture of human N-acetylgalactosamine kinase. The Journal of Biological Chemistry. 280: 32784-91. PMID 16006554 DOI: 10.1074/Jbc.M505730200 |
0.496 |
|
| 2005 |
Martí-Arbona R, Fresquet V, Thoden JB, Davis ML, Holden HM, Raushel FM. Mechanism of the reaction catalyzed by isoaspartyl dipeptidase from Escherichia coli. Biochemistry. 44: 7115-24. PMID 15882050 DOI: 10.1021/Bi050008R |
0.447 |
|
| 2005 |
Koropatkin NM, Holden HM. Structure of CDP-D-glucose 4,6-dehydratase from Salmonella typhi complexed with CDP-D-xylose. Acta Crystallographica. Section D, Biological Crystallography. 61: 365-73. PMID 15805590 DOI: 10.1107/S0907444904033876 |
0.805 |
|
| 2005 |
Thoden JB, Holden HM. The molecular architecture of galactose mutarotase/UDP-galactose 4-epimerase from Saccharomyces cerevisiae. The Journal of Biological Chemistry. 280: 21900-7. PMID 15795221 DOI: 10.1074/Jbc.M502411200 |
0.543 |
|
| 2005 |
Wasilenko J, Lucas ME, Thoden JB, Holden HM, Fridovich-Keil JL. Functional characterization of the K257R and G319E-hGALE alleles found in patients with ostensibly peripheral epimerase deficiency galactosemia. Molecular Genetics and Metabolism. 84: 32-8. PMID 15639193 DOI: 10.1016/J.Ymgme.2004.09.003 |
0.352 |
|
| 2005 |
Koropatkin NM, Cleland WW, Holden HM. Kinetic and structural analysis of alpha-D-Glucose-1-phosphate cytidylyltransferase from Salmonella typhi. The Journal of Biological Chemistry. 280: 10774-80. PMID 15634670 DOI: 10.1074/Jbc.M414111200 |
0.811 |
|
| 2005 |
Thoden JB, Timson DJ, Reece RJ, Holden HM. Molecular structure of human galactokinase: implications for type II galactosemia. The Journal of Biological Chemistry. 280: 9662-70. PMID 15590630 DOI: 10.1074/Jbc.M412916200 |
0.485 |
|
| 2004 |
Holden HM, Thoden JB, Timson DJ, Reece RJ. Galactokinase: Structure, function and role in type II galactosemia Cellular and Molecular Life Sciences. 61: 2471-2484. PMID 15526155 DOI: 10.1007/S00018-004-4160-6 |
0.475 |
|
| 2004 |
Blommel PG, Smith DW, Bingman CA, Dyer DH, Rayment I, Holden HM, Fox BG, Phillips GN. Crystal structure of gene locus At3g16990 from Arabidopsis thaliana. Proteins. 57: 221-2. PMID 15326608 DOI: 10.1002/Prot.20213 |
0.561 |
|
| 2004 |
Thoden JB, Huang X, Kim J, Raushel FM, Holden HM. Long-range allosteric transitions in carbamoyl phosphate synthetase. Protein Science : a Publication of the Protein Society. 13: 2398-405. PMID 15322282 DOI: 10.1110/Ps.04822704 |
0.539 |
|
| 2004 |
Koropatkin NM, Holden HM. Molecular structure of alpha-D-glucose-1-phosphate cytidylyltransferase from Salmonella typhi. The Journal of Biological Chemistry. 279: 44023-9. PMID 15292268 DOI: 10.1074/Jbc.M407755200 |
0.806 |
|
| 2004 |
Schulz JM, Watson AL, Sanders R, Ross KL, Thoden JB, Holden HM, Fridovich-Keil JL. Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase. The Journal of Biological Chemistry. 279: 32796-803. PMID 15175331 DOI: 10.1074/Jbc.M405005200 |
0.474 |
|
| 2004 |
Thoden JB, Taylor Ringia EA, Garrett JB, Gerlt JA, Holden HM, Rayment I. Evolution of enzymatic activity in the enolase superfamily: structural studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis. Biochemistry. 43: 5716-27. PMID 15134446 DOI: 10.1021/bi0497897 |
0.613 |
|
| 2004 |
Thoden JB, Timson DJ, Reece RJ, Holden HM. Molecular structure of human galactose mutarotase. The Journal of Biological Chemistry. 279: 23431-7. PMID 15026423 DOI: 10.1074/Jbc.M402347200 |
0.485 |
|
| 2004 |
Fresquet V, Thoden JB, Holden HM, Raushel FM. Kinetic mechanism of asparagine synthetase from Vibrio cholerae. Bioorganic Chemistry. 32: 63-75. PMID 14990305 DOI: 10.1016/J.Bioorg.2003.10.002 |
0.424 |
|
| 2004 |
Taylor Ringia EA, Garrett JB, Thoden JB, Holden HM, Rayment I, Gerlt JA. Evolution of enzymatic activity in the enolase superfamily: functional studies of the promiscuous o-succinylbenzoate synthase from Amycolatopsis. Biochemistry. 43: 224-9. PMID 14705949 DOI: 10.1021/Bi035815+ |
0.608 |
|
| 2004 |
Allard ST, Cleland WW, Holden HM. High resolution X-ray structure of dTDP-glucose 4,6-dehydratase from Streptomyces venezuelae. The Journal of Biological Chemistry. 279: 2211-20. PMID 14570895 DOI: 10.1074/Jbc.M310134200 |
0.488 |
|
| 2003 |
Hill CM, Li WS, Thoden JB, Holden HM, Raushel FM. Enhanced degradation of chemical warfare agents through molecular engineering of the phosphotriesterase active site. Journal of the American Chemical Society. 125: 8990-1. PMID 15369336 DOI: 10.1021/Ja0358798 |
0.491 |
|
| 2003 |
Holden HM, Rayment I, Thoden JB. Structure and function of enzymes of the Leloir pathway for galactose metabolism. The Journal of Biological Chemistry. 278: 43885-8. PMID 12923184 DOI: 10.1074/Jbc.R300025200 |
0.611 |
|
| 2003 |
Thoden JB, Zhuang Z, Dunaway-Mariano D, Holden HM. The structure of 4-hydroxybenzoyl-CoA thioesterase from arthrobacter sp. strain SU. The Journal of Biological Chemistry. 278: 43709-16. PMID 12907670 DOI: 10.1074/Jbc.M308198200 |
0.525 |
|
| 2003 |
Grimek TL, Holden H, Rayment I, Escalante-Semerena JC. Residues C123 and D58 of the 2-methylisocitrate lyase (PrpB) enzyme of Salmonella enterica are essential for catalysis. Journal of Bacteriology. 185: 4837-43. PMID 12897003 DOI: 10.1128/Jb.185.16.4837-4843.2003 |
0.664 |
|
| 2003 |
Raushel FM, Thoden JB, Holden HM. Enzymes with molecular tunnels. Accounts of Chemical Research. 36: 539-48. PMID 12859215 DOI: 10.1021/Ar020047K |
0.482 |
|
| 2003 |
Dyer DH, Lovell S, Thoden JB, Holden HM, Rayment I, Lan Q. The structural determination of an insect sterol carrier protein-2 with a ligand-bound C16 fatty acid at 1.35-A resolution. The Journal of Biological Chemistry. 278: 39085-91. PMID 12855689 DOI: 10.1074/Jbc.M306214200 |
0.631 |
|
| 2003 |
Thoden JB, Holden HM. Molecular structure of galactokinase. The Journal of Biological Chemistry. 278: 33305-11. PMID 12796487 DOI: 10.1074/Jbc.M304789200 |
0.502 |
|
| 2003 |
Dyer DH, Rubio LM, Thoden JB, Holden HM, Ludden PW, Rayment I. The three-dimensional structure of the core domain of Naf Y from Azotobacter vinelandii determined at 1.8-A resolution. The Journal of Biological Chemistry. 278: 32150-6. PMID 12754195 DOI: 10.1074/Jbc.M304264200 |
0.607 |
|
| 2003 |
Thoden JB, Marti-Arbona R, Raushel FM, Holden HM. High-resolution X-ray structure of isoaspartyl dipeptidase from Escherichia coli. Biochemistry. 42: 4874-82. PMID 12718528 DOI: 10.1021/Bi034233P |
0.553 |
|
| 2003 |
Thoden JB, Kim J, Raushel FM, Holden HM. The catalytic mechanism of galactose mutarotase. Protein Science : a Publication of the Protein Society. 12: 1051-9. PMID 12717027 DOI: 10.1110/Ps.0243203 |
0.56 |
|
| 2003 |
Koropatkin NM, Liu HW, Holden HM. High resolution x-ray structure of tyvelose epimerase from Salmonella typhi. The Journal of Biological Chemistry. 278: 20874-81. PMID 12642575 DOI: 10.1074/Jbc.M301948200 |
0.838 |
|
| 2002 |
Thoden JB, Kim J, Raushel FM, Holden HM. Structural and kinetic studies of sugar binding to galactose mutarotase from Lactococcus lactis. The Journal of Biological Chemistry. 277: 45458-65. PMID 12218067 DOI: 10.1074/Jbc.M208395200 |
0.504 |
|
| 2002 |
Thoden JB, Huang X, Raushel FM, Holden HM. Carbamoyl-phosphate synthetase. Creation of an escape route for ammonia. The Journal of Biological Chemistry. 277: 39722-7. PMID 12130656 DOI: 10.1074/Jbc.M206915200 |
0.525 |
|
| 2002 |
Thoden JB, Henderson JM, Fridovich-Keil JL, Holden HM. Structural analysis of the Y299C mutant of Escherichia coli UDP-galactose 4-epimerase. Teaching an old dog new tricks. The Journal of Biological Chemistry. 277: 27528-34. PMID 12019271 DOI: 10.1074/Jbc.M204413200 |
0.522 |
|
| 2002 |
Thoden JB, Holden HM, Zhuang Z, Dunaway-Mariano D. X-ray crystallographic analyses of inhibitor and substrate complexes of wild-type and mutant 4-hydroxybenzoyl-CoA thioesterase. The Journal of Biological Chemistry. 277: 27468-76. PMID 11997398 DOI: 10.1074/Jbc.M203904200 |
0.54 |
|
| 2002 |
Thoden JB, Firestine SM, Benkovic SJ, Holden HM. PurT-encoded glycinamide ribonucleotide transformylase. Accommodation of adenosine nucleotide analogs within the active site. The Journal of Biological Chemistry. 277: 23898-908. PMID 11953435 DOI: 10.1074/Jbc.M202251200 |
0.472 |
|
| 2002 |
Thoden JB, Holden HM. High resolution X-ray structure of galactose mutarotase from Lactococcus lactis. The Journal of Biological Chemistry. 277: 20854-61. PMID 11907040 DOI: 10.1074/Jbc.M201415200 |
0.533 |
|
| 2002 |
Miles BW, Thoden JB, Holden HM, Raushel FM. Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin. The Journal of Biological Chemistry. 277: 4368-73. PMID 11729189 DOI: 10.1074/Jbc.M108582200 |
0.493 |
|
| 2002 |
Thoden JB, Holden HM. Structural studies of the enzymes of the Leloir pathway Acta Crystallographica Section a Foundations of Crystallography. 58: c94-c94. DOI: 10.1107/S0108767302088785 |
0.347 |
|
| 2002 |
Koropatkin N, Thoden JB, Holden HM. Structural studies of CDP-tyvelose 2-epimerase Acta Crystallographica Section a Foundations of Crystallography. 58: c92-c92. DOI: 10.1107/S0108767302088700 |
0.767 |
|
| 2002 |
Holden HM, Thoden JB, Raushel FM. Structural and functional analyses of dihydroorotase fromEscherichia coli Acta Crystallographica Section a Foundations of Crystallography. 58: c14-c14. DOI: 10.1107/S0108767302085641 |
0.378 |
|
| 2001 |
Zhang W, Wei Y, Luo L, Taylor KL, Yang G, Dunaway-Mariano D, Benning MM, Holden HM. Histidine 90 function in 4-chlorobenzoyl-coenzyme a dehalogenase catalysis. Biochemistry. 40: 13474-82. PMID 11695894 DOI: 10.1021/Bi0114426 |
0.425 |
|
| 2001 |
Thoden JB, Phillips GN, Neal TM, Raushel FM, Holden HM. Molecular structure of dihydroorotase: a paradigm for catalysis through the use of a binuclear metal center. Biochemistry. 40: 6989-97. PMID 11401542 DOI: 10.1021/Bi010682I |
0.41 |
|
| 2001 |
Huang X, Holden HM, Raushel FM. Channeling of substrates and intermediates in enzyme-catalyzed reactions. Annual Review of Biochemistry. 70: 149-80. PMID 11395405 DOI: 10.1146/Annurev.Biochem.70.1.149 |
0.435 |
|
| 2001 |
Thoden JB, Wohlers TM, Fridovich-Keil JL, Holden HM. Molecular basis for severe epimerase deficiency galactosemia. X-ray structure of the human V94m-substituted UDP-galactose 4-epimerase. The Journal of Biological Chemistry. 276: 20617-23. PMID 11279193 DOI: 10.1074/Jbc.M101304200 |
0.52 |
|
| 2001 |
Thoden JB, Wohlers TM, Fridovich-Keil JL, Holden HM. Human UDP-galactose 4-epimerase. Accommodation of UDP-N-acetylglucosamine within the active site. The Journal of Biological Chemistry. 276: 15131-6. PMID 11279032 DOI: 10.1074/Jbc.M100220200 |
0.531 |
|
| 2001 |
Holden HM, Benning MM, Haller T, Gerlt JA. The crotonase superfamily: Divergently related enzymes that catalyze different reactions involving acyl coenzyme a thioesters Accounts of Chemical Research. 34: 145-157. PMID 11263873 DOI: 10.1021/Ar000053L |
0.469 |
|
| 2001 |
Benning MM, Shim H, Raushel FM, Holden HM. High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta. Biochemistry. 40: 2712-22. PMID 11258882 DOI: 10.1021/Bi002661E |
0.341 |
|
| 2001 |
Bauer CB, Fonseca MV, Holden HM, Thoden JB, Thompson TB, Escalante-Semerena JC, Rayment I. Three-dimensional structure of ATP:corrinoid adenosyltransferase from Salmonella typhimurium in its free state, complexed with MgATP, or complexed with hydroxycobalamin and MgATP. Biochemistry. 40: 361-74. PMID 11148030 DOI: 10.1021/Bi002145O |
0.711 |
|
| 2000 |
Bauer CB, Holden HM, Thoden JB, Smith R, Rayment I. X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain. The Journal of Biological Chemistry. 275: 38494-9. PMID 10954715 DOI: 10.1074/Jbc.M005585200 |
0.638 |
|
| 2000 |
Thoden JB, Firestine S, Nixon A, Benkovic SJ, Holden HM. Molecular structure of Escherichia coli purT-encoded glycinamide ribonucleotide transformylase Biochemistry. 39: 8791-8802. PMID 10913290 DOI: 10.1021/Bi000926J |
0.556 |
|
| 2000 |
Benning MM, Hong SB, Raushel FM, Holden HM. The binding of substrate analogs to phosphotriesterase. The Journal of Biological Chemistry. 275: 30556-60. PMID 10871616 DOI: 10.1074/Jbc.M003852200 |
0.492 |
|
| 2000 |
Thoden JB, Blanchard CZ, Holden HM, Waldrop GL. Movement of the biotin carboxylase B-domain as a result of ATP binding Journal of Biological Chemistry. 275: 16183-16190. PMID 10821865 DOI: 10.1074/Jbc.275.21.16183 |
0.528 |
|
| 2000 |
Thoden JB, Wohlers TM, Fridovich-Keil JL, Holden HM. Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase. Biochemistry. 39: 5691-701. PMID 10801319 DOI: 10.1021/Bi000215L |
0.494 |
|
| 2000 |
Raushel FM, Holden HM. Phosphotriesterase: an enzyme in search of its natural substrate. Advances in Enzymology and Related Areas of Molecular Biology. 74: 51-93. PMID 10800593 DOI: 10.1002/9780470123201.Ch2 |
0.42 |
|
| 2000 |
Benning MM, Haller T, Gerlt JA, Holden HM. New reactions in the crotonase superfamily: structure of methylmalonyl CoA decarboxylase from Escherichia coli. Biochemistry. 39: 4630-9. PMID 10769118 DOI: 10.1021/Bi9928896 |
0.522 |
|
| 1999 |
Holden HM, Thoden JB, Raushel FM. Carbamoyl phosphate synthetase: an amazing biochemical odyssey from substrate to product. Cellular and Molecular Life Sciences : Cmls. 56: 507-22. PMID 11212301 DOI: 10.1007/S000180050448 |
0.467 |
|
| 1999 |
Thoden JB, Huang X, Raushel FM, Holden HM. The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway. Biochemistry. 38: 16158-66. PMID 10587438 DOI: 10.1021/Bi991741J |
0.506 |
|
| 1999 |
Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I. Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product. Biochemistry. 38: 16146-57. PMID 10587437 DOI: 10.1021/Bi9915768 |
0.692 |
|
| 1999 |
Thoden JB, Kappock TJ, Stubbe J, Holden HM. Three-dimensional structure of N5-carboxyaminoimidazole ribonucleotide synthetase: a member of the ATP grasp protein superfamily. Biochemistry. 38: 15480-92. PMID 10569930 DOI: 10.1021/Bi991618S |
0.499 |
|
| 1999 |
Thoden JB, Raushel FM, Wesenberg G, Holden HM. The binding of inosine monophosphate to Escherichia coli carbamoyl phosphate synthetase. The Journal of Biological Chemistry. 274: 22502-7. PMID 10428826 DOI: 10.1074/Jbc.274.32.22502 |
0.534 |
|
| 1999 |
Raushel FM, Thoden JB, Holden HM. The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia. Biochemistry. 38: 7891-9. PMID 10387030 DOI: 10.1021/Bi990871P |
0.525 |
|
| 1999 |
Thoden JB, Raushel FM, Benning MM, Rayment I, Holden HM. The structure of carbamoyl phosphate synthetase determined to 2.1 A resolution. Acta Crystallographica. Section D, Biological Crystallography. 55: 8-24. PMID 10089390 DOI: 10.1107/S0907444998006234 |
0.688 |
|
| 1999 |
Thoden JB, Wesenberg G, Raushel FM, Holden HM. Carbamoyl phosphate synthetase: closure of the B-domain as a result of nucleotide binding. Biochemistry. 38: 2347-57. PMID 10029528 DOI: 10.1021/Bi982517H |
0.552 |
|
| 1999 |
Vanhooke JL, Thoden JB, Brunhuber NM, Blanchard JS, Holden HM. Phenylalanine dehydrogenase from Rhodococcus sp. M4: high-resolution X-ray analyses of inhibitory ternary complexes reveal key features in the oxidative deamination mechanism. Biochemistry. 38: 2326-39. PMID 10029526 DOI: 10.1021/Bi982244Q |
0.536 |
|
| 1999 |
Chen-Goodspeed M, Vanhooke JL, Holden HM, Raushel FM. Kinetic mechanism of kanamycin nucleotidyltransferase from Staphylococcus aureus Bioorganic Chemistry. 27: 395-408. DOI: 10.1006/Bioo.1999.1144 |
0.341 |
|
| 1999 |
Raushel FM, Thoden JB, Holden HM. The amidotransferase family of enzymes: Molecular machines for the production and delivery of ammonia Biochemistry. 38. |
0.434 |
|
| 1998 |
Holden HM, Thoden JB, Raushel FM. Carbamoyl phosphate synthetase: a tunnel runs through it. Current Opinion in Structural Biology. 8: 679-85. PMID 9914247 DOI: 10.1016/S0959-440X(98)80086-9 |
0.482 |
|
| 1998 |
Benning MM, Wesenberg G, Liu R, Taylor KL, Dunaway-Mariano D, Holden HM. The three-dimensional structure of 4-hydroxybenzoyl-CoA thioesterase from Pseudomonas sp. Strain CBS-3. The Journal of Biological Chemistry. 273: 33572-9. PMID 9837940 DOI: 10.1074/Jbc.273.50.33572 |
0.49 |
|
| 1998 |
Raushel FM, Thodent JB, Reinhart GD, Holden HM. Carbamoyl phosphate synthetase: A crooked path from substrates to products Current Opinion in Chemical Biology. 2: 624-632. PMID 9818189 DOI: 10.1016/S1367-5931(98)80094-X |
0.517 |
|
| 1998 |
Thoden JB, Holden HM. Dramatic differences in the binding of UDP-galactose and UDP-glucose to UDP-galactose 4-epimerase from Escherichia coli Biochemistry. 37: 11469-11477. PMID 9708982 DOI: 10.1021/Bi9808969 |
0.519 |
|
| 1998 |
Thoden JB, Miran SG, Phillips JC, Howard AJ, Raushel FM, Holden HM. Carbamoyl phosphate synthetase: caught in the act of glutamine hydrolysis. Biochemistry. 37: 8825-31. PMID 9636022 DOI: 10.1021/Bi9807761 |
0.551 |
|
| 1997 |
Hurley JK, Weber-Main AM, Hodges AE, Stankovich MT, Benning MM, Holden HM, Cheng H, Xia B, Markley JL, Genzor C, Gomez-Moreno C, Hafezi R, Tollin G. Iron-sulfur cluster cysteine-to-serine mutants of Anabaena -2Fe-2S- ferredoxin exhibit unexpected redox properties and are competent in electron transfer to ferredoxin:NADP+ reductase. Biochemistry. 36: 15109-17. PMID 9398238 DOI: 10.1021/Bi972001I |
0.363 |
|
| 1997 |
Hurley JK, Weber-Main AM, Stankovich MT, Benning MM, Thoden JB, Vanhooke JL, Holden HM, Chae YK, Xia B, Cheng H, Markley JL, Martinez-Júlvez M, Gómez-Moreno C, Schmeits JL, Tollin G. Structure-function relationships in Anabaena ferredoxin: correlations between X-ray crystal structures, reduction potentials, and rate constants of electron transfer to ferredoxin:NADP+ reductase for site-specific ferredoxin mutants. Biochemistry. 36: 11100-17. PMID 9287153 DOI: 10.1021/Bi9709001 |
0.37 |
|
| 1997 |
Thoden JB, Gulick AM, Holden HM. Molecular structures of the S124A, S124T, and S124V site-directed mutants of UDP-galactose 4-epimerase from Escherichia coli. Biochemistry. 36: 10685-95. PMID 9271499 DOI: 10.1021/Bi9704313 |
0.533 |
|
| 1997 |
Liu Y, Thoden JB, Kim J, Berger E, Gulick AM, Ruzicka FJ, Holden HM, Frey PA. Mechanistic roles of tyrosine 149 and serine 124 in UDP-galactose 4-epimerase from Escherichia coli. Biochemistry. 36: 10675-84. PMID 9271498 DOI: 10.1021/Bi970430A |
0.45 |
|
| 1997 |
Thoden JB, Holden HM, Wesenberg G, Raushel FM, Rayment I. Structure of carbamoyl phosphate synthetase: a journey of 96 A from substrate to product. Biochemistry. 36: 6305-16. PMID 9174345 DOI: 10.1021/Bi970503Q |
0.703 |
|
| 1997 |
Thoden JB, Hegeman AD, Wesenberg G, Chapeau MC, Frey PA, Holden HM. Structural analysis of UDP-sugar binding to UDP-galactose 4-epimerase from Escherichia coli. Biochemistry. 36: 6294-304. PMID 9174344 DOI: 10.1021/Bi970025J |
0.531 |
|
| 1997 |
Thoden JB, Ruzicka FJ, Frey PA, Rayment I, Holden HM. Structural analysis of the H166G site-directed mutant of galactose-1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: detailed description of the nucleotide sugar binding site. Biochemistry. 36: 1212-22. PMID 9063869 DOI: 10.1021/Bi9626517 |
0.733 |
|
| 1997 |
Thoden JB, Holden HM, Fisher AJ, Sinclair JF, Wesenberg G, Baldwin TO, Rayment I. Structure of the beta 2 homodimer of bacterial luciferase from Vibrio harveyi: X-ray analysis of a kinetic protein folding trap. Protein Science : a Publication of the Protein Society. 6: 13-23. PMID 9007973 DOI: 10.1002/Pro.5560060103 |
0.617 |
|
| 1997 |
Holden HM, Thoder JB, Wesenberg G, Raushel FM, Rayment I. The three dimensional structure of carbamoyl phosphate synthetase Faseb Journal. 11: A1140. |
0.576 |
|
| 1996 |
Holden HM, Wesenberg G, Raynes DA, Hartshorne DJ, Guerriero V, Rayment I. Molecular structure of a proteolytic fragment of TLP20. Acta Crystallographica. Section D, Biological Crystallography. 52: 1153-60. PMID 15299576 DOI: 10.1107/S0907444996008128 |
0.665 |
|
| 1996 |
Thoden JB, Frey PA, Holden HM. High-resolution X-ray structure of UDP-galactose 4-epimerase complexed with UDP-phenol. Protein Science : a Publication of the Protein Society. 5: 2149-61. PMID 8931134 DOI: 10.1002/Pro.5560051102 |
0.534 |
|
| 1996 |
Benning MM, Meyer TE, Holden HM. Molecular structure of a high potential cytochrome C2 isolated from Rhodopila globiformis Archives of Biochemistry and Biophysics. 333: 338-348. PMID 8809072 DOI: 10.1006/Abbi.1996.0400 |
0.448 |
|
| 1996 |
Benning MM, Taylor KL, Liu R-Q, Yang G, Xiang H, Wesenberg G, Dunaway-Mariano D, Holden HM. Structure of 4-chlorobenzoyl coenzyme A dehalogenase determined to 1.8 A resolution: an enzyme catalyst generated via adaptive mutation. Biochemistry. 35: 8103-9. PMID 8679561 DOI: 10.1021/Bi960768P |
0.564 |
|
| 1996 |
Vanhooke JL, Benning MM, Raushel FM, Holden HM. Three-dimensional structure of the zinc-containing phosphotriesterase with the bound substrate analog diethyl 4-methylbenzylphosphonate Biochemistry. 35: 6020-6025. PMID 8634243 DOI: 10.1021/Bi960325L |
0.511 |
|
| 1996 |
Thoden JB, Frey PA, Holden HM. Crystal structures of the oxidized and reduced forms of UDP-galactose 4-epimerase isolated from Escherichia coli. Biochemistry. 35: 2557-66. PMID 8611559 DOI: 10.1021/Bi952715Y |
0.53 |
|
| 1996 |
Thoden JB, Frey PA, Holden HM. Molecular structure of the NADH/UDP-glucose abortive complex of UDP-galactose 4-epimerase from Escherichia coli: implications for the catalytic mechanism. Biochemistry. 35: 5137-44. PMID 8611497 DOI: 10.1021/Bi9601114 |
0.546 |
|
| 1996 |
Vanhooke JL, Brunhuber NMW, Blanchard JS, Holden HM. Preliminary crystallographic analysis of theL-phenylalanine dehydrogenase NAD+complex fromRhodococcus Acta Crystallographica Section a Foundations of Crystallography. 52: C100-C100. DOI: 10.1107/S0108767396095116 |
0.316 |
|
| 1996 |
Pederson LC, Holden HM. Structure of an antibiotic deactivating enzyme Acta Crystallographica Section a Foundations of Crystallography. 52: C122-C122. DOI: 10.1107/S0108767396094287 |
0.361 |
|
| 1996 |
Rayment I, Fisher AJ, Smith CA, Gulick A, Smith R, Holden HM, Sutoh K. Structural basis of myosin motility Acta Crystallographica Section a Foundations of Crystallography. 52: C209-C209. DOI: 10.1107/S010876739609099X |
0.593 |
|
| 1995 |
Benning MM, Kuo JM, Raushel FM, Holden HM. Three-dimensional structure of the binuclear metal center of phosphotriesterase Biochemistry. 34: 7973-7978. PMID 7794910 DOI: 10.1021/Bi00025A002 |
0.445 |
|
| 1995 |
Hurley JK, Caffrey MS, Markley JL, Cheng H, Xia B, Chae YK, Holden HM, Tollin G. Mutations of surface residues in Anabaena vegetative and heterocyst ferredoxin that affect thermodynamic stability as determined by guanidine hydrochloride denaturation. Protein Science : a Publication of the Protein Society. 4: 58-64. PMID 7773177 DOI: 10.1002/Pro.5560040108 |
0.341 |
|
| 1995 |
Rayment I, Holden HM, Sellers JR, Fananapazir L, Epstein ND. Structural interpretation of the mutations in the beta-cardiac myosin that have been implicated in familial hypertrophic cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 92: 3864-8. PMID 7731997 DOI: 10.1073/Pnas.92.9.3864 |
0.579 |
|
| 1995 |
Fisher AJ, Smith CA, Thoden JB, Smith R, Sutoh K, Holden HM, Rayment I. X-ray structures of the myosin motor domain of Dictyostelium discoideum complexed with MgADP.BeFx and MgADP.AlF4-. Biochemistry. 34: 8960-72. PMID 7619795 DOI: 10.1021/Bi00028A004 |
0.645 |
|
| 1995 |
Pedersen LC, Benning MM, Holden HM. Structural investigation of the antibiotic and ATP-binding sites in kanamycin nucleotidyltransferase Biochemistry. 34: 13305-13311. PMID 7577914 DOI: 10.1021/Bi00041A005 |
0.625 |
|
| 1994 |
Rayment I, Holden HM. The three-dimensional structure of a molecular motor. Trends in Biochemical Sciences. 19: 129-34. PMID 8203020 DOI: 10.1016/0968-0004(94)90206-2 |
0.583 |
|
| 1994 |
Larsen TM, Laughlin LT, Holden HM, Rayment I, Reed GH. Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate. Biochemistry. 33: 6301-9. PMID 8193145 DOI: 10.1021/Bi00186A033 |
0.637 |
|
| 1994 |
Benning MM, Meyer TE, Holden HM. X-ray structure of the cytochrome c2 isolated from Paracoccus denitrificans refined to 1.7-Å resolution Archives of Biochemistry and Biophysics. 310: 460-466. PMID 8179333 DOI: 10.1006/Abbi.1994.1193 |
0.44 |
|
| 1994 |
Benning MM, Meyer TE, Rayment I, Holden HM. Molecular structure of the oxidized high-potential iron-sulfur protein isolated from Ectothiorhodospira vacuolata. Biochemistry. 33: 2476-83. PMID 8117708 DOI: 10.1021/Bi00175A016 |
0.622 |
|
| 1994 |
Holden HM, Jacobson BL, Hurley JK, Tollin G, Oh BH, Skjeldal L, Chae YK, Cheng H, Xia B, Markley JL. Structure-function studies of [2Fe-2S] ferredoxins. Journal of Bioenergetics and Biomembranes. 26: 67-88. PMID 8027024 DOI: 10.1007/Bf00763220 |
0.419 |
|
| 1994 |
Benning MM, Kuo JM, Raushel FM, Holden HM. Three-dimensional structure of phosphotriesterase: An enzyme capable of detoxifying organophosphate nerve agents Biochemistry. 33: 15001-15007. PMID 7999757 DOI: 10.1021/Bi00254A008 |
0.482 |
|
| 1994 |
Haunerland NH, Jacobson BL, Wesenberg G, Rayment I, Holden HM. Three-dimensional structure of the muscle fatty-acid-binding protein isolated from the desert locust Schistocerca gregaria. Biochemistry. 33: 12378-85. PMID 7918460 DOI: 10.1021/Bi00207A004 |
0.647 |
|
| 1994 |
Waldrop G, Holden HM, Rayment I. Preliminary X-ray crystallographic analysis of biotin carboxylase isolated from Escherichia coli. Journal of Molecular Biology. 235: 367-9. PMID 7904651 DOI: 10.1016/S0022-2836(05)80042-7 |
0.651 |
|
| 1993 |
Blaber M, Isackson PJ, Holden HM, Bradshaw RA. Synthetic chimeras of mouse growth factor-associated glandular kallikreins. II. Growth factor binding properties. Protein Science : a Publication of the Protein Society. 2: 1220-8. PMID 8401207 DOI: 10.1002/Pro.5560020804 |
0.333 |
|
| 1993 |
Rypniewski WR, Holden HM, Rayment I. Structural consequences of reductive methylation of lysine residues in hen egg white lysozyme: an X-ray analysis at 1.8-A resolution. Biochemistry. 32: 9851-8. PMID 8373783 DOI: 10.1021/Bi00088A041 |
0.651 |
|
| 1993 |
Jacobson BL, Chae YK, Markley JL, Rayment I, Holden HM. Molecular structure of the oxidized, recombinant, heterocyst [2Fe-2S] ferredoxin from Anabaena 7120 determined to 1.7-A resolution. Biochemistry. 32: 6788-93. PMID 8329401 DOI: 10.1021/Bi00077A033 |
0.622 |
|
| 1993 |
Schröder RR, Manstein DJ, Jahn W, Holden H, Rayment I, Holmes KC, Spudich JA. Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1. Nature. 364: 171-4. PMID 8321290 DOI: 10.1038/364171A0 |
0.494 |
|
| 1993 |
Rayment I, Holden HM, Whittaker M, Yohn CB, Lorenz M, Holmes KC, Milligan RA. Structure of the actin-myosin complex and its implications for muscle contraction. Science (New York, N.Y.). 261: 58-65. PMID 8316858 DOI: 10.1126/Science.8316858 |
0.573 |
|
| 1993 |
Rayment I, Rypniewski WR, Schmidt-Bäse K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM. Three-dimensional structure of myosin subfragment-1: a molecular motor. Science (New York, N.Y.). 261: 50-8. PMID 8316857 DOI: 10.1126/Science.8316857 |
0.594 |
|
| 1993 |
Sakon J, Liao HH, Kanikula AM, Benning MM, Rayment I, Holden HM. Molecular structure of kanamycin nucleotidyltransferase determined to 3.0-A resolution. Biochemistry. 32: 11977-84. PMID 8218273 DOI: 10.1021/Bi00096A006 |
0.817 |
|
| 1993 |
Rayment I, Holden HM. Myosin subfragment-1: structure and function of a molecular motor. Current opinion in structural biology 1993, 3:944-952 Current Opinion in Structural Biology. 3: 944-952. DOI: 10.1016/0959-440X(93)90160-M |
0.577 |
|
| 1992 |
Bauer AJ, Rayment I, Frey PA, Holden HM. The molecular structure of UDP-galactose 4-epimerase from Escherichia coli determined at 2.5 A resolution. Proteins. 12: 372-81. PMID 1579570 DOI: 10.1002/Prot.340120409 |
0.685 |
|
| 1992 |
Jacobson BL, Chae YK, Böhme H, Markley JL, Holden HM. Crystallization and preliminary analysis of oxidized, recombinant, heterocyst [2Fe-2S] ferredoxin from Anabaena 7120. Archives of Biochemistry and Biophysics. 294: 279-81. PMID 1550351 DOI: 10.1016/0003-9861(92)90169-W |
0.439 |
|
| 1992 |
Rayment I, Wesenberg G, Meyer TE, Cusanovich MA, Holden HM. Three-dimensional structure of the high-potential iron-sulfur protein isolated from the purple phototrophic bacterium Rhodocyclus tenuis determined and refined at 1.5 A resolution. Journal of Molecular Biology. 228: 672-86. PMID 1453470 DOI: 10.1016/0022-2836(92)90849-F |
0.637 |
|
| 1992 |
Banning MM, Smith AF, Wells MA, Holden HM. Crystallization, structure determination and least-squares refinement to 1.75 Å resolution of the fatty-acid-binding protein isolated from Manduca sexta L Journal of Molecular Biology. 228: 208-219. PMID 1447782 DOI: 10.1016/0022-2836(92)90501-A |
0.438 |
|
| 1992 |
Holden HM, Ito M, Hartshorne DJ, Rayment I. X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 A resolution. Journal of Molecular Biology. 227: 840-51. PMID 1404391 DOI: 10.1016/0022-2836(92)90226-A |
0.634 |
|
| 1992 |
Kanikula AM, Liao HH, Sakon J, Holden HM, Rayment I. Crystallization and preliminary crystallographic analysis of a thermostable mutant of kanamycin nucleotidyltransferase. Archives of Biochemistry and Biophysics. 295: 1-4. PMID 1315501 DOI: 10.1016/0003-9861(92)90479-G |
0.771 |
|
| 1992 |
Frey PA, Bauer AJ, Vanhooke JL, Konopka JM, Rayment I, Holden HM. Chemical spectroscopic and crystallographic studies of UDP-galactose 4-epimerase from Escherichia coli. Journal of Nutritional Science and Vitaminology. 461-4. PMID 1297789 DOI: 10.3177/Jnsv.38.Special_461 |
0.577 |
|
| 1991 |
Bauer AJ, Rayment I, Frey PA, Holden HM. The isolation, purification, and preliminary crystallographic characterization of UDP-galactose-4-epimerase from Escherichia coli Proteins: Structure, Function and Genetics. 9: 135-142. PMID 2008433 DOI: 10.1002/Prot.340090207 |
0.637 |
|
| 1991 |
Breiter DR, Kanost MR, Benning MM, Wesenberg G, Law JH, Wells MA, Rayment I, Holden HM. Molecular structure of an apolipoprotein determined at 2.5-A resolution. Biochemistry. 30: 603-8. PMID 1988048 DOI: 10.1021/Bi00217A002 |
0.613 |
|
| 1991 |
Holden HM, Rayment I. Trimethyllead acetate: a first-choice heavy atom derivative for protein crystallography. Archives of Biochemistry and Biophysics. 291: 187-94. PMID 1929430 DOI: 10.1016/0003-9861(91)90122-Y |
0.573 |
|
| 1991 |
Breiter DR, Meyer TE, Rayment I, Holden HM. The molecular structure of the high potential iron-sulfur protein isolated from Ectothiorhodospira halophila determined at 2.5-A resolution. The Journal of Biological Chemistry. 266: 18660-7. PMID 1917989 DOI: 10.2210/Pdb2Hip/Pdb |
0.634 |
|
| 1991 |
Skjeldal L, Westler WM, Oh BH, Krezel AM, Holden HM, Jacobson BL, Rayment I, Markley JL. Two-dimensional magnetization exchange spectroscopy of Anabaena 7120 ferredoxin. Nuclear Overhauser effect and electron self-exchange cross peaks from amino acid residues surrounding the 2Fe-2S* cluster. Biochemistry. 30: 7363-8. PMID 1906741 DOI: 10.1021/Bi00244A002 |
0.555 |
|
| 1991 |
Rypniewski WR, Breiter DR, Benning MM, Wesenberg G, Oh BH, Markley JL, Rayment I, Holden HM. Crystallization and structure determination to 2.5-A resolution of the oxidized [2Fe-2S] ferredoxin isolated from Anabaena 7120. Biochemistry. 30: 4126-31. PMID 1902376 DOI: 10.1021/Bi00231A003 |
0.623 |
|
| 1991 |
Caffrey MS, Daldal F, Holden HM, Cusanovich MA. Importance of a conserved hydrogen-bonding network in cytochromes c to their redox potentials and stabilities. Biochemistry. 30: 4119-25. PMID 1850617 DOI: 10.1021/Bi00231A002 |
0.394 |
|
| 1991 |
Benning MM, Wesenberg G, Caffrey MS, Bartsch RG, Meyer TE, Cusanovich MA, Rayment I, Holden HM. Molecular structure of cytochrome c2 isolated from Rhodobacter capsulatus determined at 2.5 A resolution. Journal of Molecular Biology. 220: 673-85. PMID 1651396 DOI: 10.1016/0022-2836(91)90109-J |
0.669 |
|
| 1988 |
Holden HM, Kanost MR, Law JH, Rayment I, Wells MA. Crystallization and preliminary analysis of crystals of apolipophorin III isolated from Locusta migratoria. The Journal of Biological Chemistry. 263: 3960-2. PMID 3346231 |
0.538 |
|
| 1988 |
Holden HM, Matthews BW. The binding of L-valyl-L-tryptophan to crystalline thermolysin illustrates the mode of interaction of a product of peptide hydrolysis Journal of Biological Chemistry. 263: 3256-3260. PMID 3343246 DOI: 10.2210/Pdb3Tmn/Pdb |
0.368 |
|
| 1987 |
Tronrud DE, Holden HM, Matthews BW. Structures of two thermolysin-inhibitor complexes that differ by a single hydrogen bond Science. 235: 571-574. PMID 3810156 DOI: 10.1126/Science.3810156 |
0.382 |
|
| 1987 |
Holden HM, Rypniewski WR, Law JH, Rayment I. The molecular structure of insecticyanin from the tobacco hornworm Manduca sexta L. at 2.6 A resolution. The Embo Journal. 6: 1565-70. PMID 3608987 DOI: 10.1002/J.1460-2075.1987.Tb02401.X |
0.64 |
|
| 1987 |
Birktoft JJ, Holden HM, Hamlin R, Xuong NH, Banaszak LJ. Structure of L-3-hydroxyacyl-coenzyme A dehydrogenase: preliminary chain tracing at 2.8-A resolution. Proceedings of the National Academy of Sciences of the United States of America. 84: 8262-6. PMID 3479790 DOI: 10.1073/Pnas.84.23.8262 |
0.709 |
|
| 1987 |
Holden HM, Tronrud DE, Monzingo AF, Weaver LH, Matthews BW. Slow- and fast-binding inhibitors of thermolysin display different modes of binding: Crystallographic analysis of extended phosphonamidate transition-state analogues Biochemistry. 26: 8542-8553. PMID 3442675 DOI: 10.1021/Bi00400A008 |
0.408 |
|
| 1987 |
Holden HM, Meyer TE, Cusanovich MA, Daldal F, Rayment I. Crystallization and preliminary analysis of crystals of cytochrome c2 from Rhodopseudomonas capsulata Journal of Molecular Biology. 195: 229-231. PMID 2821271 DOI: 10.1016/0022-2836(87)90341-X |
0.572 |
|
| 1987 |
Holden HM, Tronrud DE, Monzingo AF, Weaver LH, Matthews BW. Structural basis of the action of thermolysin and the zinc proteases Acta Crystallographica Section a Foundations of Crystallography. 43: C17-C17. DOI: 10.1107/S010876738708509X |
0.375 |
|
| 1986 |
Holden HM, Meyer TE, Cusanovich MA, Rayment I. Crystallization and preliminary analysis of crystals of high potential iron-sulfur protein from Rhodospirillum tenue The Journal of Biological Chemistry. 261: 4219-4220. PMID 3949809 |
0.553 |
|
| 1986 |
Holden HM, Law JH, Rayment I. Crystallization of insecticyanin from the hemolymph of the tobacco hornworm Manduca sexta L. in a form suitable for a high resolution structure determination. The Journal of Biological Chemistry. 261: 4217-8. PMID 3949808 |
0.54 |
|
| 1986 |
Holden HM, Meyer TE, Cusanovich MA, Rayment I. Crystallization of a high potential iron-sulfur protein from the halophilic phototrophic bacterium Ectothiorhodospira halophila Journal of Biological Chemistry. 261: 14746-14747. PMID 3771550 |
0.539 |
|
| 1984 |
Birktoft JJ, Banaszak LJ, Holden HM, Ross J, Roderick SL, Sacchettini J, Hamlin RC, Xoung N. L-3-Hydroxyacyl coenzyme-A dehydrogenase – structural studies at 3.5 Å resolution Acta Crystallographica Section a Foundations of Crystallography. 40: C30-C30. DOI: 10.1107/S0108767384098901 |
0.619 |
|
| 1983 |
Holden HM, Banaszak LJ. L-3-hydroxyacyl coenzyme A dehydrogenase. The location of NAD binding sites and the bilobal subunit structure. The Journal of Biological Chemistry. 258: 2383-9. PMID 6822567 |
0.637 |
|
| 1981 |
Holden HM, Banaszak LJ, Frieden C, McLoughlin DJ. Differences in the binding of coenzyme to L-3-hydroxyacyl-coenzyme A dehydrogenase in the crystalline state and in solution. Febs Letters. 132: 15-8. PMID 7297684 DOI: 10.1016/0014-5793(81)80417-6 |
0.691 |
|
| 1981 |
Holden HM, Banaszak LJ. The molecular structure ofL-3-hydroxyacyl coenzyme A dehydrogenase Acta Crystallographica Section a Foundations of Crystallography. 37: C37-C37. DOI: 10.1107/S0108767381098498 |
0.607 |
|
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