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David J. Hosfield, Ph.D. - Publications

Affiliations: 
2001 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Area:
Biochemistry
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Bennett MJ, Wu Y, Boloor A, Matuszkiewicz J, O'Connell SM, Shi L, Stansfield RK, Del Rosario JR, Veal JM, Hosfield DJ, Xu J, Kaldor SW, Stafford JA, Betancort JM. Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29657099 DOI: 10.1016/J.Bmcl.2018.04.016  0.309
2018 Nie Z, Shi L, Lai C, O'Connell SM, Xu J, Stansfield RK, Hosfield DJ, Veal JM, Stafford JA. Structure-based design and discovery of potent and selective KDM5 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 29627262 DOI: 10.1016/J.Bmcl.2018.03.083  0.307
2017 Cheruvallath ZS, Gwaltney SL, Sabat M, Tang M, Wang H, Jennings A, Hosfield D, Lee B, Wu Y, Halkowycz P, Grimshaw CE. Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators. Bioorganic & Medicinal Chemistry Letters. PMID 28512030 DOI: 10.1016/J.Bmcl.2017.04.041  0.303
2016 Kiryanov A, Natala S, Jones B, McBride C, Feher V, Lam B, Liu Y, Honda K, Uchiyama N, Kawamoto T, Hikichi Y, Zhang L, Hosfield D, Skene R, Zou H, et al. Structure-based design and SAR development of 5,6-dihydroimidazolo[1,5-f]pteridine derivatives as novel Polo-like kinase-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 28169164 DOI: 10.1016/J.Bmcl.2016.10.009  0.314
2013 Tomita N, Hayashi Y, Suzuki S, Oomori Y, Aramaki Y, Matsushita Y, Iwatani M, Iwata H, Okabe A, Awazu Y, Isono O, Skene RJ, Hosfield DJ, Miki H, Kawamoto T, et al. Structure-based discovery of cellular-active allosteric inhibitors of FAK. Bioorganic & Medicinal Chemistry Letters. 23: 1779-85. PMID 23414845 DOI: 10.1016/J.Bmcl.2013.01.047  0.302
2013 Tsutakawa SE, Shin DS, Mol CD, Izumi T, Arvai AS, Mantha AK, Szczesny B, Ivanov IN, Hosfield DJ, Maiti B, Pique ME, Frankel KA, Hitomi K, Cunningham RP, Mitra S, et al. Conserved structural chemistry for incision activity in structurally non-homologous apurinic/apyrimidinic endonuclease APE1 and endonuclease IV DNA repair enzymes. The Journal of Biological Chemistry. 288: 8445-55. PMID 23355472 DOI: 10.1074/Jbc.M112.422774  0.759
2013 Iwatani M, Iwata H, Okabe A, Skene RJ, Tomita N, Hayashi Y, Aramaki Y, Hosfield DJ, Hori A, Baba A, Miki H. Discovery and characterization of novel allosteric FAK inhibitors. European Journal of Medicinal Chemistry. 61: 49-60. PMID 22819505 DOI: 10.1016/J.Ejmech.2012.06.035  0.312
2010 Fradera X, Vu D, Nimz O, Skene R, Hosfield D, Wynands R, Cooke AJ, Haunsø A, King A, Bennett DJ, McGuire R, Uitdehaag JC. X-ray structures of the LXRalpha LBD in its homodimeric form and implications for heterodimer signaling. Journal of Molecular Biology. 399: 120-32. PMID 20382159 DOI: 10.1016/J.Jmb.2010.04.005  0.311
2009 Mol CD, Okada K, Hosfield DJ. Protein Kinase Structural Biology: Methods and Strategies for Targeted Drug Discovery Kinase Inhibitor Drugs. 485-500. DOI: 10.1002/9780470524961.ch19  0.631
2008 Garcin ED, Hosfield DJ, Desai SA, Haas BJ, Björas M, Cunningham RP, Tainer JA. DNA apurinic-apyrimidinic site binding and excision by endonuclease IV. Nature Structural & Molecular Biology. 15: 515-22. PMID 18408731 DOI: 10.1038/Nsmb.1414  0.692
2008 Hosfield DJ, Mol CD. Targeting inactive kinases: Structure as foundation for cancer drug discovery Cancer Drug Design and Discovery. 229-252. DOI: 10.1016/B978-012369448-5.50013-6  0.633
2006 Garcin-Hosfield ED, Arvai AS, Rosenfeld RJ, Bonaventura J, Scharber MA, Bruns CM, Hosfield DJ, Jane Lloyd S, MacCoss MJ, Yates J, Tiso M, Stuehr DJ, Tainer JA, Getzoff ED. P188. Structural insights into NOS regulatory mechanisms: What? where? how? Nitric Oxide. 14: 77-78. DOI: 10.1016/J.Niox.2006.04.258  0.462
2005 Hosfield DJ, Wu Y, Skene RJ, Hilgers M, Jennings A, Snell GP, Aertgeerts K. Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation. The Journal of Biological Chemistry. 280: 4639-48. PMID 15513927 DOI: 10.1074/Jbc.M411104200  0.355
2004 Mol CD, Fabbro D, Hosfield DJ. Structural insights into the conformational selectivity of STI-571 and related kinase inhibitors. Current Opinion in Drug Discovery & Development. 7: 639-48. PMID 15503866  0.645
2004 Garcin ED, Bruns CM, Lloyd SJ, Hosfield DJ, Tiso M, Gachhui R, Stuehr DJ, Tainer JA, Getzoff ED. Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase. The Journal of Biological Chemistry. 279: 37918-27. PMID 15208315 DOI: 10.1074/Jbc.M406204200  0.495
2004 Chapados BR, Hosfield DJ, Han S, Qiu J, Yelent B, Shen B, Tainer JA. Structural basis for FEN-1 substrate specificity and PCNA-mediated activation in DNA replication and repair. Cell. 116: 39-50. PMID 14718165 DOI: 10.1016/S0092-8674(03)01036-5  0.803
2004 Hosfield DJ, Zhang Y, Dougan DR, Broun A, Tari LW, Swanson RV, Finn J. Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis. The Journal of Biological Chemistry. 279: 8526-9. PMID 14672944 DOI: 10.2210/Pdb1Rtr/Pdb  0.425
2003 Shouldice SR, Dougan DR, Williams PA, Skene RJ, Snell G, Scheibe D, Kirby S, Hosfield DJ, McRee DE, Schryvers AB, Tari LW. Crystal structure of Pasteurella haemolytica ferric ion-binding protein A reveals a novel class of bacterial iron-binding proteins. The Journal of Biological Chemistry. 278: 41093-8. PMID 12882966 DOI: 10.1074/Jbc.M306821200  0.305
2002 Adak S, Bilwes AM, Panda K, Hosfield D, Aulak KS, McDonald JF, Tainer JA, Getzoff ED, Crane BR, Stuehr DJ. Cloning, expression, and characterization of a nitric oxide synthase protein from Deinococcus radiodurans. Proceedings of the National Academy of Sciences of the United States of America. 99: 107-12. PMID 11756668 DOI: 10.1073/Pnas.012470099  0.505
2001 Hosfield DJ, Daniels DS, Mol CD, Putnam CD, Parikh SS, Tainer JA. DNA damage recognition and repair pathway coordination revealed by the structural biochemistry of DNA repair enzymes. Progress in Nucleic Acid Research and Molecular Biology. 68: 315-47. PMID 11554309 DOI: 10.1016/S0079-6603(01)68110-8  0.728
2001 Chapados BR, Chai Q, Hosfield DJ, Qiu J, Shen B, Tainer JA. Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication. Journal of Molecular Biology. 307: 541-56. PMID 11254381 DOI: 10.1006/Jmbi.2001.4494  0.774
2000 Mol CD, Hosfield DJ, Tainer JA. Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means. Mutation Research. 460: 211-29. PMID 10946230 DOI: 10.1016/S0921-8777(00)00028-8  0.798
1999 Hosfield DJ, Guan Y, Haas BJ, Cunningham RP, Tainer JA. Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis. Cell. 98: 397-408. PMID 10458614 DOI: 10.1016/S0092-8674(00)81968-6  0.718
1999 Parikh SS, Mol CD, Hosfield DJ, Tainer JA. Envisioning the molecular choreography of DNA base excision repair. Current Opinion in Structural Biology. 9: 37-47. PMID 10047578 DOI: 10.1016/S0959-440X(99)80006-2  0.8
1998 Hosfield DJ, Mol CD, Shen B, Tainer JA. Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity. Cell. 95: 135-46. PMID 9778254 DOI: 10.1016/S0092-8674(00)81789-4  0.805
1998 Hosfield DJ, Frank G, Weng Y, Tainer JA, Shen B. Newly discovered archaebacterial flap endonucleases show a structure-specific mechanism for DNA substrate binding and catalysis resembling human flap endonuclease-1. The Journal of Biological Chemistry. 273: 27154-61. PMID 9765234 DOI: 10.1074/Jbc.273.42.27154  0.669
1998 Shen B, Qiu J, Hosfield D, Tainer JA. Flap endonuclease homologs in archaebacteria exist as independent proteins. Trends in Biochemical Sciences. 23: 171-3. PMID 9612080 DOI: 10.1016/S0968-0004(98)01199-2  0.428
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