Thomas J. Urban, Ph.D. - Publications

Affiliations: 
2007 Pharmaceutical Sciences and Pharmacogenomics University of California, San Francisco, San Francisco, CA 
Area:
Pharmacology

54 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Lu YF, Mauger DM, Goldstein DB, Urban TJ, Weeks KM, Bradrick SS. IFNL3 mRNA structure is remodeled by a functional non-coding polymorphism associated with hepatitis C virus clearance. Scientific Reports. 5: 16037. PMID 26531896 DOI: 10.1038/srep16037  0.96
2015 Mousallem T, Urban TJ, McSweeney KM, Kleinstein SE, Zhu M, Adeli M, Parrott RE, Roberts JL, Krueger B, Buckley RH, Goldstein DB. Clinical application of whole-genome sequencing in patients with primary immunodeficiency. The Journal of Allergy and Clinical Immunology. PMID 25981738 DOI: 10.1016/j.jaci.2015.02.040  0.96
2015 Welch MA, Köck K, Urban TJ, Brouwer KL, Swaan PW. Toward predicting drug-induced liver injury: parallel computational approaches to identify multidrug resistance protein 4 and bile salt export pump inhibitors. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 725-34. PMID 25735837 DOI: 10.1124/dmd.114.062539  0.96
2015 Wu LS, Rower JE, Burton JR, Anderson PL, Hammond KP, Baouchi-Mokrane F, Everson GT, Urban TJ, D'Argenio DZ, Kiser JJ. Population pharmacokinetic modeling of plasma and intracellular ribavirin concentrations in patients with chronic hepatitis C virus infection. Antimicrobial Agents and Chemotherapy. 59: 2179-88. PMID 25645847 DOI: 10.1128/AAC.04618-14  0.96
2015 Lu YF, Goldstein DB, Urban TJ, Bradrick SS. Interferon-λ4 is a cell-autonomous type III interferon associated with pre-treatment hepatitis C virus burden. Virology. 476: 334-40. PMID 25577150 DOI: 10.1016/j.virol.2014.12.020  0.96
2015 Church RJ, Gatti DM, Urban TJ, Long N, Yang X, Shi Q, Eaddy JS, Mosedale M, Ballard S, Churchill GA, Navarro V, Watkins PB, Threadgill DW, Harrill AH. Sensitivity to hepatotoxicity due to epigallocatechin gallate is affected by genetic background in diversity outbred mice. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 76: 19-26. PMID 25446466 DOI: 10.1016/j.fct.2014.11.008  0.96
2015 Usachov V, Urban TJ, Fontana RJ, Gross A, Iyer S, Omary MB, Strnad P. Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury Bmc Medicine. 13. DOI: 10.1186/s12916-015-0418-0  0.96
2014 Mousallem T, Yang J, Urban TJ, Wang H, Adeli M, Parrott RE, Roberts JL, Goldstein DB, Buckley RH, Zhong XP. A nonsense mutation in IKBKB causes combined immunodeficiency. Blood. 124: 2046-50. PMID 25139357 DOI: 10.1182/blood-2014-04-571265  0.96
2014 Urban TJ, Daly AK, Aithal GP. Genetic basis of drug-induced liver injury: present and future. Seminars in Liver Disease. 34: 123-33. PMID 24879978 DOI: 10.1055/s-0034-1375954  0.96
2014 Nelson D, Yoshida EM, Paulson MS, Hengen PN, Ge D, Kanwar B, McNally J, Pang PS, Subramanian GM, McHutchison JG, Urbanek P, Lawitz E, Urban TJ. Genome-wide association study to characterize serum bilirubin elevations in patients with HCV treated with GS-9256, an HCV NS3 serine protease inhibitor. Antiviral Therapy. 19: 679-86. PMID 24503447 DOI: 10.3851/IMP2747  0.96
2014 Köck K, Ferslew BC, Netterberg I, Yang K, Urban TJ, Swaan PW, Stewart PW, Brouwer KL. Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 665-74. PMID 24154606 DOI: 10.1124/dmd.113.054304  0.96
2014 Jilg N, Lin W, Hong J, Schaefer EA, Wolski D, Meixong J, Goto K, Brisac C, Chusri P, Fusco DN, Chevaliez S, Luther J, Kumthip K, Urban TJ, Peng LF, et al. Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus. Hepatology (Baltimore, Md.). 59: 1250-61. PMID 23913866 DOI: 10.1002/hep.26653  0.96
2014 Urban TJ, Tillmann H. Drug-Induced Liver Injury Handbook of Pharmacogenomics and Stratified Medicine. 467-477. DOI: 10.1016/B978-0-12-386882-4.00022-0  0.96
2013 Clark PJ, Aghemo A, Degasperi E, Galmozzi E, Urban TJ, Vock DM, Patel K, Thompson AJ, Rumi MG, D'Ambrosio R, Muir AJ, Colombo M. Inosine triphosphatase deficiency helps predict anaemia, anaemia management and response in chronic hepatitis C therapy. Journal of Viral Hepatitis. 20: 858-66. PMID 24304455 DOI: 10.1111/jvh.12113  0.96
2013 Ko DC, Urban TJ. Understanding human variation in infectious disease susceptibility through clinical and cellular GWAS. Plos Pathogens. 9: e1003424. PMID 23935492 DOI: 10.1371/journal.ppat.1003424  0.96
2013 Urban TJ. Whole-genome sequencing in pharmacogenetics. Pharmacogenomics. 14: 345-8. PMID 23438878 DOI: 10.2217/pgs.12.211  0.96
2012 Wei R, Yang F, Urban TJ, Li L, Chalasani N, Flockhart DA, Liu W. Impact of the Interaction between 3'-UTR SNPs and microRNA on the Expression of Human Xenobiotic Metabolism Enzyme and Transporter Genes. Frontiers in Genetics. 3: 248. PMID 23181071 DOI: 10.3389/fgene.2012.00248  0.96
2012 Urban TJ, Shen Y, Stolz A, Chalasani N, Fontana RJ, Rochon J, Ge D, Shianna KV, Daly AK, Lucena MI, Nelson MR, Molokhia M, Aithal GP, Floratos A, Pe'er I, et al. Limited contribution of common genetic variants to risk for liver injury due to a variety of drugs. Pharmacogenetics and Genomics. 22: 784-95. PMID 22968431 DOI: 10.1097/FPC.0b013e3283589a76  0.96
2012 Zhu Q, Ge D, Heinzen EL, Dickson SP, Urban TJ, Zhu M, Maia JM, He M, Zhao Q, Shianna KV, Goldstein DB. Prioritizing genetic variants for causality on the basis of preferential linkage disequilibrium. American Journal of Human Genetics. 91: 422-34. PMID 22939045 DOI: 10.1016/j.ajhg.2012.07.010  0.96
2012 Urban TJ, Goldstein DB, Watkins PB. Genetic basis of susceptibility to drug-induced liver injury: what have we learned and where do we go from here? Pharmacogenomics. 13: 735-8. PMID 22594502 DOI: 10.2217/pgs.12.45  0.96
2012 Clark PJ, Thompson AJ, Zhu Q, Vock DM, Zhu M, Patel K, Harrison SA, Naggie S, Ge D, Tillmann HL, Urban TJ, Shianna K, Fellay J, Goodman Z, Noviello S, et al. The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection. Digestive Diseases and Sciences. 57: 2213-21. PMID 22543885 DOI: 10.1007/s10620-012-2171-y  0.96
2012 Clark PJ, Thompson AJ, Zhu M, Vock DM, Zhu Q, Ge D, Patel K, Harrison SA, Urban TJ, Naggie S, Fellay J, Tillmann HL, Shianna K, Noviello S, Pedicone LD, et al. Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response. Journal of Viral Hepatitis. 19: 332-40. PMID 22497812 DOI: 10.1111/j.1365-2893.2011.01553.x  0.96
2012 McCormack M, Urban TJ, Shianna KV, Walley N, Pandolfo M, Depondt C, Chaila E, O'Conner GD, Kasperavičiūtė D, Radtke RA, Heinzen EL, Sisodiya SM, Delanty N, Cavalleri GL. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. Pharmacogenomics. 13: 399-405. PMID 22379998 DOI: 10.2217/pgs.11.165  0.96
2012 Cirulli ET, Urban TJ, Marino SE, Linney KN, Birnbaum AK, Depondt C, Attix DK, Radtke RA, Goldstein DB. Genetic and environmental correlates of topiramate-induced cognitive impairment. Epilepsia. 53: e5-8. PMID 22091778 DOI: 10.1111/j.1528-1167.2011.03322.x  0.96
2012 Thompson AJ, Clark PJ, Singh A, Ge D, Fellay J, Zhu M, Zhu Q, Urban TJ, Patel K, Tillmann HL, Naggie S, Afdhal NH, Jacobson IM, Esteban R, Poordad F, et al. Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients. Journal of Hepatology. 56: 313-9. PMID 21703177 DOI: 10.1016/j.jhep.2011.04.021  0.96
2011 Pelak K, Need AC, Fellay J, Shianna KV, Feng S, Urban TJ, Ge D, De Luca A, Martinez-Picado J, Wolinsky SM, Martinson JJ, Jamieson BD, Bream JH, Martin MP, Borrow P, et al. Copy number variation of KIR genes influences HIV-1 control. Plos Biology. 9: e1001208. PMID 22140359 DOI: 10.1371/journal.pbio.1001208  0.96
2011 Lucena MI, Molokhia M, Shen Y, Urban TJ, Aithal GP, Andrade RJ, Day CP, Ruiz-Cabello F, Donaldson PT, Stephens C, Pirmohamed M, Romero-Gomez M, Navarro JM, Fontana RJ, Miller M, et al. Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. Gastroenterology. 141: 338-47. PMID 21570397 DOI: 10.1053/j.gastro.2011.04.001  0.96
2011 Hitomi Y, Cirulli ET, Fellay J, McHutchison JG, Thompson AJ, Gumbs CE, Shianna KV, Urban TJ, Goldstein DB. Inosine triphosphate protects against ribavirin-induced adenosine triphosphate loss by adenylosuccinate synthase function Gastroenterology. 140: 1314-1321. PMID 21199653 DOI: 10.1053/j.gastro.2010.12.038  0.96
2010 Urban TJ, Thompson AJ, Bradrick SS, Fellay J, Schuppan D, Cronin KD, Hong L, McKenzie A, Patel K, Shianna KV, McHutchison JG, Goldstein DB, Afdhal N. IL28B genotype is associated with differential expression of intrahepatic interferon-stimulated genes in patients with chronic hepatitis C. Hepatology (Baltimore, Md.). 52: 1888-96. PMID 20931559 DOI: 10.1002/hep.23912  0.96
2010 Thompson AJ, Fellay J, Patel K, Tillmann HL, Naggie S, Ge D, Urban TJ, Shianna KV, Muir AJ, Fried MW, Afdhal NH, Goldstein DB, McHutchison JG. Variants in the ITPA gene protect against ribavirin-induced hemolytic anemia and decrease the need for ribavirin dose reduction. Gastroenterology. 139: 1181-9. PMID 20547162 DOI: 10.1053/j.gastro.2010.06.016  0.96
2010 Heinzen EL, Radtke RA, Urban TJ, Cavalleri GL, Depondt C, Need AC, Walley NM, Nicoletti P, Ge D, Catarino CB, Duncan JS, Kasperavici?te D, Tate SK, Caboclo LO, Sander JW, et al. Rare deletions at 16p13.11 predispose to a diverse spectrum of sporadic epilepsy syndromes. American Journal of Human Genetics. 86: 707-18. PMID 20398883 DOI: 10.1016/j.ajhg.2010.03.018  0.96
2010 Urban TJ. Race, ethnicity, ancestry, and pharmacogenetics. The Mount Sinai Journal of Medicine, New York. 77: 133-9. PMID 20309922 DOI: 10.1002/msj.20168  0.96
2010 Fellay J, Thompson AJ, Ge D, Gumbs CE, Urban TJ, Shianna KV, Little LD, Qiu P, Bertelsen AH, Watson M, Warner A, Muir AJ, Brass C, Albrecht J, Sulkowski M, et al. ITPA gene variants protect against anaemia in patients treated for chronic hepatitis C. Nature. 464: 405-8. PMID 20173735 DOI: 10.1038/nature08825  0.96
2010 Chaudhry AS, Urban TJ, Lamba JK, Birnbaum AK, Remmel RP, Subramanian M, Strom S, You JH, Kasperaviciute D, Catarino CB, Radtke RA, Sisodiya SM, Goldstein DB, Schuetz EG. CYP2C9*1B promoter polymorphisms, in linkage with CYP2C19*2, affect phenytoin autoinduction of clearance and maintenance dose. The Journal of Pharmacology and Experimental Therapeutics. 332: 599-611. PMID 19855097 DOI: 10.1124/jpet.109.161026  0.96
2009 Fellay J, Ge D, Shianna KV, Colombo S, Ledergerber B, Cirulli ET, Urban TJ, Zhang K, Gumbs CE, Smith JP, Castagna A, Cozzi-Lepri A, De Luca A, Easterbrook P, Günthard HF, et al. Common genetic variation and the control of HIV-1 in humans. Plos Genetics. 5: e1000791. PMID 20041166 DOI: 10.1371/journal.pgen.1000791  0.96
2009 Urban TJ, Weintrob AC, Fellay J, Colombo S, Shianna KV, Gumbs C, Rotger M, Pelak K, Dang KK, Detels R, Martinson JJ, O'Brien SJ, Letvin NL, McMichael AJ, Haynes BF, et al. CCL3L1 and HIV/AIDS susceptibility. Nature Medicine. 15: 1110-2. PMID 19812560 DOI: 10.1038/nm1009-1110  0.96
2009 Ge D, Fellay J, Thompson AJ, Simon JS, Shianna KV, Urban TJ, Heinzen EL, Qiu P, Bertelsen AH, Muir AJ, Sulkowski M, McHutchison JG, Goldstein DB. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature. 461: 399-401. PMID 19684573 DOI: 10.1038/nature08309  0.96
2009 McBride BF, Yang T, Liu K, Urban TJ, Giacomini KM, Kim RB, Roden DM. The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channel. Journal of Cardiovascular Pharmacology. 54: 63-71. PMID 19528813 DOI: 10.1097/FJC.0b013e3181abc288  0.96
2009 Chen Y, Li S, Brown C, Cheatham S, Castro RA, Leabman MK, Urban TJ, Chen L, Yee SW, Choi JH, Huang Y, Brett CM, Burchard EG, Giacomini KM. Effect of genetic variation in the organic cation transporter 2 on the renal elimination of metformin. Pharmacogenetics and Genomics. 19: 497-504. PMID 19483665 DOI: 10.1097/FPC.0b013e32832cc7e9  0.96
2009 Tahara H, Yee SW, Urban TJ, Hesselson S, Castro RA, Kawamoto M, Stryke D, Johns SJ, Ferrin TE, Kwok PY, Giacomini KM. Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5). The Journal of Pharmacology and Experimental Therapeutics. 329: 262-71. PMID 19141711 DOI: 10.1124/jpet.108.146449  0.96
2008 Ge D, Zhang K, Need AC, Martin O, Fellay J, Urban TJ, Telenti A, Goldstein DB. WGAViewer: software for genomic annotation of whole genome association studies. Genome Research. 18: 640-3. PMID 18256235 DOI: 10.1101/gr.071571.107  0.96
2008 Cropp CD, Komori T, Shima JE, Urban TJ, Yee SW, More SS, Giacomini KM. Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. Molecular Pharmacology. 73: 1151-8. PMID 18216183 DOI: 10.1124/mol.107.043117  0.96
2008 Urban TJ, Brown C, Castro RA, Shah N, Mercer R, Huang Y, Brett CM, Burchard EG, Giacomini KM. Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clinical Pharmacology and Therapeutics. 83: 416-21. PMID 17609685 DOI: 10.1038/sj.clpt.6100271  0.96
2007 Urban TJ, Yang C, Lagpacan LL, Brown C, Castro RA, Taylor TR, Huang CC, Stryke D, Johns SJ, Kawamoto M, Carlson EJ, Ferrin TE, Burchard EG, Giacomini KM. Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). Pharmacogenetics and Genomics. 17: 773-82. PMID 17700366 DOI: 10.1097/FPC.0b013e3281c6d08e.  0.96
2006 Urban TJ, Gallagher RC, Brown C, Castro RA, Lagpacan LL, Brett CM, Taylor TR, Carlson EJ, Ferrin TE, Burchard EG, Packman S, Giacomini KM. Functional genetic diversity in the high-affinity carnitine transporter OCTN2 (SLC22A5). Molecular Pharmacology. 70: 1602-11. PMID 16931768 DOI: 10.1124/mol.106.028126  0.96
2006 Shu Y, Urban TJ, Leabman MK, Fujita T, Erdman AR, Lagpacan LL, Brown C, Castro RA, Huang CC, Stryke D, Kawamoto M, Johns SJ, Taylor TR, Chan W, De La Cruz M, et al. PharmGKB submission update: V. PMT submissions of genetic variation in SLC22 family transporters. Pharmacological Reviews. 58: 3-4. PMID 16507878 DOI: 10.1124/pr.58.1.2  0.96
2006 Urban TJ, Sebro R, Hurowitz EH, Leabman MK, Badagnani I, Lagpacan LL, Risch N, Giacomini KM. Functional genomics of membrane transporters in human populations. Genome Research. 16: 223-30. PMID 16354753 DOI: 10.1101/gr.4356206  0.96
2006 Fujita T, Urban TJ, Leabman MK, Fujita K, Giacomini KM. Transport of drugs in the kidney by the human organic cation transporter, OCT2 and its genetic variants. Journal of Pharmaceutical Sciences. 95: 25-36. PMID 16307453 DOI: 10.1002/jps.20536  0.96
2006 Erdman AR, Mangravite LM, Urban TJ, Lagpacan LL, Castro RA, de la Cruz M, Chan W, Huang CC, Johns SJ, Kawamoto M, Stryke D, Taylor TR, Carlson EJ, Ferrin TE, Brett CM, et al. The human organic anion transporter 3 (OAT3; SLC22A8): genetic variation and functional genomics. American Journal of Physiology. Renal Physiology. 290: F905-12. PMID 16291576 DOI: 10.1152/ajprenal.00272.2005  0.96
2006 Urban TJ, Giacomini KM. Organic Cation Transporters Drug Transporters: Molecular Characterization and Role in Drug Disposition. 11-33. DOI: 10.1002/9780470140505.ch2  0.96
2005 Urban TJ, Giacomini KM, Risch N. Haplotype structure and ethnic-specific allele frequencies at the OCTN locus: implications for the genetics of Crohn's disease. Inflammatory Bowel Diseases. 11: 78-9. PMID 15674120 DOI: 10.1097/00054725-200501000-00014  0.96
2004 Gray JH, Mangravite LM, Owen RP, Urban TJ, Chan W, Carlson EJ, Huang CC, Kawamoto M, Johns SJ, Stryke D, Ferrin TE, Giacomini KM. Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations. Molecular Pharmacology. 65: 512-9. PMID 14978229 DOI: 10.1124/mol.65.3.512  0.96
2003 Shu Y, Leabman MK, Feng B, Mangravite LM, Huang CC, Stryke D, Kawamoto M, Johns SJ, DeYoung J, Carlson E, Ferrin TE, Herskowitz I, Giacomini KM. Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1. Proceedings of the National Academy of Sciences of the United States of America. 100: 5902-7. PMID 12719534 DOI: 10.1073/pnas.0730858100  0.96
2003 Leabman MK, Huang CC, DeYoung J, Carlson EJ, Taylor TR, de la Cruz M, Johns SJ, Stryke D, Kawamoto M, Urban TJ, Kroetz DL, Ferrin TE, Clark AG, Risch N, Herskowitz I, et al. Natural variation in human membrane transporter genes reveals evolutionary and functional constraints. Proceedings of the National Academy of Sciences of the United States of America. 100: 5896-901. PMID 12719533 DOI: 10.1073/pnas.0730857100  0.96
Show low-probability matches.