Manuel Covarrubias - Publications

Affiliations: 
Thomas Jefferson University, Philadelphia, PA, United States 
Area:
K channels

91 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Clatot J, Currin CB, Liang Q, Pipatpolkai T, Massey SL, Helbig I, Delemotte L, Vogels TP, Covarrubias M, Goldberg EM. A structurally precise mechanism links an epilepsy-associated potassium channel mutation to interneuron dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 121: e2307776121. PMID 38194456 DOI: 10.1073/pnas.2307776121  0.538
2022 Alexander TD, Muqeem T, Zhi L, Tymanskyj SR, Covarrubias ML. Tunable Action Potential Repolarization Governed by Kv3.4 Channels in Dorsal Root Ganglion Neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 36198500 DOI: 10.1523/JNEUROSCI.1210-22.2022  0.845
2022 Chi G, Liang Q, Sridhar A, Cowgill JB, Sader K, Radjainia M, Qian P, Castro-Hartmann P, Venkaya S, Singh NK, McKinley G, Fernandez-Cid A, Mukhopadhyay SMM, Burgess-Brown NA, Delemotte L, ... Covarrubias M, et al. Cryo-EM structure of the human Kv3.1 channel reveals gating control by the cytoplasmic T1 domain. Nature Communications. 13: 4087. PMID 35840580 DOI: 10.1038/s41467-022-29594-w  0.487
2021 Yang E, Bu W, Suma A, Carnevale V, Grasty KC, Loll PJ, Woll K, Bhanu N, Garcia BA, Eckenhoff RG, Covarrubias M. Binding Sites and the Mechanism of Action of Propofol and a Photoreactive Analogue in Prokaryotic Voltage-Gated Sodium Channels. Acs Chemical Neuroscience. 12: 3898-3914. PMID 34607428 DOI: 10.1021/acschemneuro.1c00495  0.818
2021 Ojala KS, Ginebaugh SP, Wu M, Miller EW, Ortiz G, Covarrubias M, Meriney SD. A high affinity, partial antagonist effect of 3,4-diaminopyridine mediates action potential broadening and enhancement of transmitter release at NMJs. The Journal of Biological Chemistry. 100302. PMID 33465376 DOI: 10.1016/j.jbc.2021.100302  0.512
2021 Zemel BM, Zhi L, Brown EV, Tymanskyj SR, Liang Q, Covarrubias M. PKCε associates with the Kv3.4 channel to promote its expression in a kinase activity-dependent manner. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21241. PMID 33368632 DOI: 10.1096/fj.201901877R  0.868
2018 Zemel BM, Ritter DM, Covarrubias M, Muqeem T. A-Type K Channels in Dorsal Root Ganglion Neurons: Diversity, Function, and Dysfunction. Frontiers in Molecular Neuroscience. 11: 253. PMID 30127716 DOI: 10.3389/Fnmol.2018.00253  0.842
2018 Wang Y, Yang E, Wells MM, Bondarenko V, Woll K, Carnevale V, Granata D, Klein ML, Eckenhoff RG, Dailey WP, Covarrubias M, Tang P, Xu Y. Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites. The Journal of General Physiology. PMID 30018039 DOI: 10.1085/Jgp.201811993  0.832
2018 Yang E, Granata D, Eckenhoff RG, Carnevale V, Covarrubias M. Propofol inhibits prokaryotic voltage-gated Na channels by promoting activation-coupled inactivation. The Journal of General Physiology. PMID 30018038 DOI: 10.1085/Jgp.201711924  0.832
2018 Yang E, Zhi L, Liang Q, Covarrubias M. Electrophysiological Analysis of Voltage-Gated Ion Channel Modulation by General Anesthetics. Methods in Enzymology. 602: 339-368. PMID 29588038 DOI: 10.1016/Bs.Mie.2018.01.013  0.821
2018 Muqeem T, Ghosh B, Pinto V, Lepore AC, Covarrubias M. Regulation of nociceptive glutamatergic signaling by presynaptic Kv3.4 channels in the rat spinal dorsal horn. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29540546 DOI: 10.1523/Jneurosci.3212-17.2018  0.86
2018 Woll KA, Zhou X, Bhanu NV, Garcia BA, Covarrubias M, Miller KW, Eckenhoff RG. Identification of binding sites contributing to volatile anesthetic effects on GABA type A receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201701347R. PMID 29505303 DOI: 10.1096/Fj.201701347R  0.306
2017 Zemel BM, Muqeem T, Brown EV, Goulão M, Urban MW, Tymanskyj SR, Lepore AC, Covarrubias M. Calcineurin dysregulation underlies spinal cord injury-induced K(+) channel dysfunction in DRG neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28751455 DOI: 10.1523/Jneurosci.0434-17.2017  0.825
2017 Woll KA, Peng W, Liang Q, Zhi L, Jacobs JA, Maciunas L, Bhanu N, Garcia BA, Covarrubias M, Loll PJ, Dailey WP, Eckenhoff RG. Photoaffinity ligand for the inhalational anesthetic sevoflurane allows mechanistic insight into potassium channel modulation. Acs Chemical Biology. PMID 28333442 DOI: 10.1021/Acschembio.7B00222  0.628
2017 Bu W, Liang Q, Zhi L, Maciunas L, Loll PJ, Eckenhoff RG, Covarrubias M. Sites and Functional Consequence of Alkylphenol Anesthetic Binding to Kv1.2 Channels. Molecular Neurobiology. PMID 28204960 DOI: 10.1007/S12035-017-0437-2  0.586
2017 Yang E, Granata D, Eckenhoff R, Carnevale V, Covarrubias M. Propofol is a Potent Gating Modifier of Voltage-Gated Sodium Channels Biophysical Journal. 112: 105. DOI: 10.1016/J.Bpj.2016.11.601  0.848
2017 Szanto TG, Fineberg JD, Covarrubias M, Varga Z, Panyi G. Analysis of the State-Dependent Block of Shaker IR by bTBuA Biophysical Journal. 112: 247a. DOI: 10.1016/J.Bpj.2016.11.1351  0.883
2016 Fineberg JD, Szanto TG, Panyi G, Covarrubias M. Closed-state inactivation involving an internal gate in Kv4.1 channels modulates pore blockade by intracellular quaternary ammonium ions. Scientific Reports. 6: 31131. PMID 27502553 DOI: 10.1038/Srep31131  0.878
2016 Woll KA, Murlidaran S, Pinch BJ, Hénin J, Wang X, Salari R, Covarrubias M, Dailey WP, Brannigan G, Garcia BA, Eckenhoff RG. A Novel Bifunctional Alkylphenol Anesthetic Allows Characterization of GABAA Receptor Subunit Binding Selectivity in Synaptosomes. The Journal of Biological Chemistry. PMID 27462076 DOI: 10.1074/Jbc.M116.736975  0.323
2016 Yang E, Carnevale V, Covarrubias M. Inhibition of a Voltage-Gated Sodium Channel by Propofol Involves Modulation of Slow Inactivation Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2355  0.757
2015 Liang Q, Anderson WD, Jones ST, Souza CS, Hosoume JM, Treptow W, Covarrubias M. Positive Allosteric Modulation of Kv Channels by Sevoflurane: Insights into the Structural Basis of Inhaled Anesthetic Action. Plos One. 10: e0143363. PMID 26599217 DOI: 10.1371/journal.pone.0143363  0.702
2015 Covarrubias M, Barber AF, Carnevale V, Treptow W, Eckenhoff RG. Mechanistic Insights into the Modulation of Voltage-Gated Ion Channels by Inhalational Anesthetics. Biophysical Journal. 109: 2003-11. PMID 26588560 DOI: 10.1016/J.Bpj.2015.09.032  0.854
2015 Ritter DM, Zemel BM, Lepore AC, Covarrubias M. Kv3.4 channel function and dysfunction in nociceptors. Channels (Austin, Tex.). 9: 209-17. PMID 26039360 DOI: 10.1080/19336950.2015.1056949  0.842
2015 Woll KA, Weiser BP, Liang Q, Meng T, McKinstry-Wu A, Pinch B, Dailey WP, Gao WD, Covarrubias M, Eckenhoff RG. Role for the Propofol Hydroxyl in Anesthetic Protein Target Molecular Recognition. Acs Chemical Neuroscience. 6: 927-35. PMID 25799399 DOI: 10.1021/Acschemneuro.5B00078  0.353
2015 Ritter DM, Zemel BM, Hala TJ, O'Leary ME, Lepore AC, Covarrubias M. Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 1260-73. PMID 25609640 DOI: 10.1523/Jneurosci.1594-14.2015  0.871
2015 Liang Q, Alvaro G, Large C, Covarrubias M. A New Class of Positive Gating Modulators of hKv3.2 Channels: Insights into the Mechanism of Action Biophysical Journal. 108: 1-7. DOI: 10.1016/J.Bpj.2014.11.710  0.64
2015 Jones ST, Hosoume J, Stock L, Souza C, Treptow W, Covarrubias M. Sevoflurane Potentiates Kv Channels by Inhibiting a Late Non-Conducting State: A Plausible Mechanism of General Anesthetic Action Implicating the Selectivity Filter Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.1536  0.572
2014 Barber AF, Carnevale V, Klein ML, Eckenhoff RG, Covarrubias M. Modulation of a voltage-gated Na+ channel by sevoflurane involves multiple sites and distinct mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 111: 6726-31. PMID 24753583 DOI: 10.1073/Pnas.1405768111  0.854
2014 Souza CS, Hosoume JM, Covarrubias M, Treptow W. Exploring Anesthetic Binding on Voltage-Gated Cation Channels Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.2702  0.542
2014 Covarrubias M, Fineberg JD. Two-in-One: Activation and Inactivation at the Intracellular Gate of a Kv Channel Biophysical Journal. 106: 15a. DOI: 10.1016/J.Bpj.2013.11.136  0.885
2013 Covarrubias M. Dipeptidyl-peptidase-like proteins cast in a new role: enabling scorpion toxin block of A-type K+ channels. The Journal of Physiology. 591: 2373-4. PMID 23678148 DOI: 10.1113/jphysiol.2013.254441  0.69
2013 Zhang J, Qu X, Covarrubias M, Germann MW. Insight into the modulation of Shaw2 Kv channels by general anesthetics: structural and functional studies of S4-S5 linker and S6 C-terminal peptides in micelles by NMR. Biochimica Et Biophysica Acta. 1828: 595-601. PMID 23031574 DOI: 10.1016/J.Bbamem.2012.09.025  0.439
2013 Barber AF, Raju SG, Lebard D, Carnevale V, Klein ML, Covarrubias M. Volatile General Anesthetic Interactions with a Bacterial Sodium Channel Biophysical Journal. 104: 136a. DOI: 10.1016/J.Bpj.2012.11.777  0.846
2013 Fineberg JD, Covarrubias M. Is the Activation Gate Closed in Kv Channel Closed-State Inactivation? Biophysical Journal. 104: 127a. DOI: 10.1016/J.Bpj.2012.11.729  0.865
2013 Urbani B, Covarrubias M. Gating Interactions between the Cytoplasmic T1 Domain and Pore of a Kv Channel Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.728  0.444
2013 Liang Q, Barber AF, Souza CS, Treptow W, Covarrubias M. Novel Modulation of a Kv1.2 Chimera by Volatile Anesthetics Biophysical Journal. 104: 126a. DOI: 10.1016/J.Bpj.2012.11.725  0.836
2013 Ritter D, Zemel B, Hala T, Lepore A, Covarrubias M. Kv3.4 Channel Expression, Modulation and Function in a Spinal Cord Injury Model of Neuropathic Pain Biophysical Journal. 104: 465a. DOI: 10.1016/J.Bpj.2012.11.2573  0.863
2012 Fineberg JD, Ritter DM, Covarrubias M. Modeling-independent elucidation of inactivation pathways in recombinant and native A-type Kv channels. The Journal of General Physiology. 140: 513-27. PMID 23109714 DOI: 10.1085/Jgp.201210869  0.868
2012 Barber AF, Liang Q, Covarrubias M. Novel activation of voltage-gated K(+) channels by sevoflurane. The Journal of Biological Chemistry. 287: 40425-32. PMID 23038249 DOI: 10.1074/Jbc.M112.405787  0.875
2012 Ritter DM, Ho C, O'Leary ME, Covarrubias M. Modulation of Kv3.4 channel N-type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons. The Journal of Physiology. 590: 145-61. PMID 22063632 DOI: 10.1113/Jphysiol.2011.218560  0.835
2012 Barber AF, Liang Q, Covarrubias M. Sevoflurane: A Potent General Anesthetic Enhancer of Kv Channel Activation Biophysical Journal. 102: 533a. DOI: 10.1016/J.Bpj.2011.11.2914  0.84
2011 Barber AF, Liang Q, Amaral C, Treptow W, Covarrubias M. Molecular mapping of general anesthetic sites in a voltage-gated ion channel. Biophysical Journal. 101: 1613-22. PMID 21961587 DOI: 10.1016/J.Bpj.2011.08.026  0.862
2011 Cheng L, Yung A, Covarrubias M, Radice GL. Cortactin is required for N-cadherin regulation of Kv1.5 channel function. The Journal of Biological Chemistry. 286: 20478-89. PMID 21507952 DOI: 10.1074/jbc.M111.218560  0.551
2011 Bähring R, Covarrubias M. Mechanisms of closed-state inactivation in voltage-gated ion channels. The Journal of Physiology. 589: 461-79. PMID 21098008 DOI: 10.1113/jphysiol.2010.191965  0.672
2011 Barber AF, Liang Q, Amaral C, Eckenhoff RG, Treptow W, Covarrubias M. Visualization of the General Anesthetic Site in a K+ Channel Biophysical Journal. 100: 100a. DOI: 10.1016/J.Bpj.2010.12.755  0.846
2011 Fineberg JD, Covarrubias M. "Must Channels Open Before Inactivating?" Redux Biophysical Journal. 100: 580a. DOI: 10.1016/J.Bpj.2010.12.3353  0.888
2010 Santiago-Castillo JA, Covarrubias M, Sánchez-Rodríguez JE, Perez-Cornejo P, Arreola J. Simulating complex ion channel kinetics with IonChannelLab. Channels (Austin, Tex.). 4: 422-8. PMID 20935453 DOI: 10.4161/chan.4.5.13404  0.544
2010 Eckenhoff RG, Xi J, Shimaoka M, Bhattacharji A, Covarrubias M, Dailey WP. Azi-isoflurane, a Photolabel Analog of the Commonly Used Inhaled General Anesthetic Isoflurane. Acs Chemical Neuroscience. 1: 139-145. PMID 20228895 DOI: 10.1021/Cn900014M  0.373
2010 Bhattacharji A, Klett N, Go RC, Covarrubias M. Inhalational anaesthetics and n-alcohols share a site of action in the neuronal Shaw2 Kv channel. British Journal of Pharmacology. 159: 1475-85. PMID 20136839 DOI: 10.1111/j.1476-5381.2010.00642.x  0.642
2009 Jerng HH, Dougherty K, Covarrubias M, Pfaffinger PJ. A novel N-terminal motif of dipeptidyl peptidase-like proteins produces rapid inactivation of KV4.2 channels by a pore-blocking mechanism. Channels (Austin, Tex.). 3: 448-61. PMID 19901547 DOI: 10.4161/Chan.3.6.10216  0.595
2009 Phuket TR, Covarrubias M. Kv4 Channels Underlie the Subthreshold-Operating A-type K-current in Nociceptive Dorsal Root Ganglion Neurons. Frontiers in Molecular Neuroscience. 2: 3. PMID 19668710 DOI: 10.3389/neuro.02.003.2009  0.636
2009 Dougherty K, Tu L, Deutsch C, Covarrubias M. The dipeptidyl-aminopeptidase-like protein 6 is an integral voltage sensor-interacting beta-subunit of neuronal K(V)4.2 channels. Channels (Austin, Tex.). 3: 122-8. PMID 19372736 DOI: 10.4161/Chan.3.2.8333  0.572
2009 Kaulin YA, De Santiago-Castillo JA, Rocha CA, Nadal MS, Rudy B, Covarrubias M. The dipeptidyl-peptidase-like protein DPP6 determines the unitary conductance of neuronal Kv4.2 channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3242-51. PMID 19279261 DOI: 10.1016/J.Bpj.2008.12.826  0.696
2008 Schwenk J, Zolles G, Kandias NG, Neubauer I, Kalbacher H, Covarrubias M, Fakler B, Bentrop D. NMR analysis of KChIP4a reveals structural basis for control of surface expression of Kv4 channel complexes. The Journal of Biological Chemistry. 283: 18937-46. PMID 18458082 DOI: 10.1074/jbc.M800976200  0.501
2008 Covarrubias M, Bhattacharji A, De Santiago-Castillo JA, Dougherty K, Kaulin YA, Na-Phuket TR, Wang G. The neuronal Kv4 channel complex. Neurochemical Research. 33: 1558-67. PMID 18357523 DOI: 10.1007/s11064-008-9650-8  0.681
2008 Dougherty K, De Santiago-Castillo JA, Covarrubias M. Gating charge immobilization in Kv4.2 channels: the basis of closed-state inactivation. The Journal of General Physiology. 131: 257-73. PMID 18299396 DOI: 10.1085/jgp.200709938  0.695
2008 Amarillo Y, De Santiago-Castillo JA, Dougherty K, Maffie J, Kwon E, Covarrubias M, Rudy B. Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons. The Journal of Physiology. 586: 2093-106. PMID 18276729 DOI: 10.1113/Jphysiol.2007.150540  0.717
2008 Rojas P, Garst-Orozco J, Baban B, de Santiago-Castillo JA, Covarrubias M, Salkoff L. Cumulative activation of voltage-dependent KVS-1 potassium channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 757-65. PMID 18199775 DOI: 10.1523/Jneurosci.3825-07.2008  0.807
2008 Kaulin YA, De Santiago-Castillo JA, Rocha CA, Covarrubias M. Mechanism of the modulation of Kv4:KChIP-1 channels by external K+. Biophysical Journal. 94: 1241-51. PMID 17951301 DOI: 10.1529/biophysj.107.117796  0.645
2007 Wang G, Strang C, Pfaffinger PJ, Covarrubias M. Zn2+-dependent redox switch in the intracellular T1-T1 interface of a Kv channel. The Journal of Biological Chemistry. 282: 13637-47. PMID 17331952 DOI: 10.1074/jbc.M609182200  0.576
2006 Dougherty K, Covarrubias M. A dipeptidyl aminopeptidase-like protein remodels gating charge dynamics in Kv4.2 channels. The Journal of General Physiology. 128: 745-53. PMID 17130523 DOI: 10.1085/jgp.200609668  0.636
2006 Fawcett GL, Santi CM, Butler A, Harris T, Covarrubias M, Salkoff L. Mutant analysis of the Shal (Kv4) voltage-gated fast transient K+ channel in Caenorhabditis elegans. The Journal of Biological Chemistry. 281: 30725-35. PMID 16899454 DOI: 10.1074/Jbc.M605814200  0.848
2006 Bhattacharji A, Kaplan B, Harris T, Qu X, Germann MW, Covarrubias M. The concerted contribution of the S4-S5 linker and the S6 segment to the modulation of a Kv channel by 1-alkanols. Molecular Pharmacology. 70: 1542-54. PMID 16887933 DOI: 10.1124/Mol.106.026187  0.592
2006 Wang G, Covarrubias M. Voltage-dependent gating rearrangements in the intracellular T1-T1 interface of a K+ channel. The Journal of General Physiology. 127: 391-400. PMID 16533897 DOI: 10.1085/jgp.200509442  0.592
2005 Wang G, Shahidullah M, Rocha CA, Strang C, Pfaffinger PJ, Covarrubias M. Functionally active t1-t1 interfaces revealed by the accessibility of intracellular thiolate groups in kv4 channels. The Journal of General Physiology. 126: 55-69. PMID 15955876 DOI: 10.1085/jgp.200509288  0.581
2005 Covarrubias M, Bhattacharji A, Harris T, Kaplan B, Germann MW. Alcohol and anesthetic action at the gate of a voltage-dependent K+ channel International Congress Series. 1283: 55-60. DOI: 10.1016/j.ics.2005.06.045  0.504
2004 Jerng HH, Pfaffinger PJ, Covarrubias M. Molecular physiology and modulation of somatodendritic A-type potassium channels. Molecular and Cellular Neurosciences. 27: 343-69. PMID 15555915 DOI: 10.1016/J.Mcn.2004.06.011  0.688
2003 Shahidullah M, Harris T, Germann MW, Covarrubias M. Molecular features of an alcohol binding site in a neuronal potassium channel. Biochemistry. 42: 11243-52. PMID 14503874 DOI: 10.1021/Bi034738F  0.514
2003 Harris T, Graber AR, Covarrubias M. Allosteric modulation of a neuronal K+ channel by 1-alkanols is linked to a key residue in the activation gate. American Journal of Physiology. Cell Physiology. 285: C788-96. PMID 12958027 DOI: 10.1152/ajpcell.00113.2003  0.672
2003 Shahidullah M, Covarrubias M. The link between ion permeation and inactivation gating of Kv4 potassium channels. Biophysical Journal. 84: 928-41. PMID 12547775 DOI: 10.1016/S0006-3495(03)74910-8  0.719
2002 Beck EJ, Bowlby M, An WF, Rhodes KJ, Covarrubias M. Remodelling inactivation gating of Kv4 channels by KChIP1, a small-molecular-weight calcium-binding protein. The Journal of Physiology. 538: 691-706. PMID 11826158 DOI: 10.1113/jphysiol.2001.013127  0.703
2002 Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, et al. Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain. Proceedings of the National Academy of Sciences of the United States of America. 99: 1035-40. PMID 11805342 DOI: 10.1073/Pnas.022509299  0.692
2001 Beck EJ, Covarrubias M. Kv4 channels exhibit modulation of closed-state inactivation in inside-out patches. Biophysical Journal. 81: 867-83. PMID 11463631 DOI: 10.1016/S0006-3495(01)75747-5  0.64
2000 Walters FS, Covarrubias M, Ellingson JS. Potent inhibition of the aortic smooth muscle maxi-K channel by clinical doses of ethanol. American Journal of Physiology. Cell Physiology. 279: C1107-15. PMID 11003591 DOI: 10.1152/Ajpcell.2000.279.4.C1107  0.494
2000 Harris T, Shahidullah M, Ellingson JS, Covarrubias M. General anesthetic action at an internal protein site involving the S4-S5 cytoplasmic loop of a neuronal K(+) channel. The Journal of Biological Chemistry. 275: 4928-36. PMID 10671530 DOI: 10.1074/jbc.275.7.4928  0.644
1999 Velasco I, Covarrubias M, Tapia R. Injection of Xenopus oocytes with mRNA from cultured neurons induces new currents and susceptibility to the damaging action of ruthenium red. Brain Research Bulletin. 48: 383-6. PMID 10357069 DOI: 10.1016/S0361-9230(99)00010-6  0.618
1999 Jerng HH, Shahidullah M, Covarrubias M. Inactivation gating of Kv4 potassium channels: molecular interactions involving the inner vestibule of the pore. The Journal of General Physiology. 113: 641-60. PMID 10228180 DOI: 10.1085/Jgp.113.5.641  0.677
1999 Antz C, Bauer T, Kalbacher H, Frank R, Covarrubias M, Kalbitzer HR, Ruppersberg JP, Baukrowitz T, Fakler B. Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate. Nature Structural Biology. 6: 146-50. PMID 10048926 DOI: 10.1038/5833  0.564
1998 Velasco I, Beck EJ, Covarrubias M. Receptor-coupled regulation of K+ channel N-type inactivation. Neurobiology (Budapest, Hungary). 6: 23-32. PMID 9713829  0.46
1998 Beck EJ, Sorensen RG, Slater SJ, Covarrubias M. Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action. The Journal of General Physiology. 112: 71-84. PMID 9649584 DOI: 10.1085/Jgp.112.1.71  0.485
1997 Jerng HH, Covarrubias M. K+ channel inactivation mediated by the concerted action of the cytoplasmic N- and C-terminal domains. Biophysical Journal. 72: 163-74. PMID 8994601 DOI: 10.1016/S0006-3495(97)78655-7  0.652
1995 Covarrubias M, Vyas TB, Escobar L, Wei A. Alcohols inhibit a cloned potassium channel at a discrete saturable site. Insights into the molecular basis of general anesthesia. The Journal of Biological Chemistry. 270: 19408-16. PMID 7642622 DOI: 10.1074/Jbc.270.33.19408  0.633
1995 Navaratnam DS, Escobar L, Covarrubias M, Oberholtzer JC. Permeation properties and differential expression across the auditory receptor epithelium of an inward rectifier K+ channel cloned from the chick inner ear. The Journal of Biological Chemistry. 270: 19238-45. PMID 7642595 DOI: 10.1074/jbc.270.33.19238  0.674
1994 Covarrubias M, Wei A, Salkoff L, Vyas TB. Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate. Neuron. 13: 1403-12. PMID 7993631 DOI: 10.1016/0896-6273(94)90425-1  0.779
1993 Chabala LD, Bakry N, Covarrubias M. Low molecular weight poly(A)+ mRNA species encode factors that modulate gating of a non-Shaker A-type K+ channel. The Journal of General Physiology. 102: 713-28. PMID 7903683  0.41
1992 Salkoff L, Baker K, Butler A, Covarrubias M, Pak MD, Wei A. An essential 'set' of K+ channels conserved in flies, mice and humans. Trends in Neurosciences. 15: 161-6. PMID 1377421 DOI: 10.1016/0166-2236(92)90165-5  0.795
1991 Pak MD, Baker K, Covarrubias M, Butler A, Ratcliffe A, Salkoff L. mShal, a subfamily of A-type K+ channel cloned from mammalian brain. Proceedings of the National Academy of Sciences of the United States of America. 88: 4386-90. PMID 2034678 DOI: 10.1073/Pnas.88.10.4386  0.768
1991 Pak MD, Covarrubias M, Ratcliffe A, Salkoff L. A mouse brain homolog of the Drosophila Shab K+ channel with conserved delayed-rectifier properties. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 869-80. PMID 2002364 DOI: 10.1523/Jneurosci.11-03-00869.1991  0.81
1991 Covarrubias M, Wei AA, Salkoff L. Shaker, Shal, Shab, and Shaw express independent K+ current systems. Neuron. 7: 763-73. PMID 1742024 DOI: 10.1016/0896-6273(91)90279-9  0.741
1990 Wei A, Covarrubias M, Butler A, Baker K, Pak M, Salkoff L. K+ current diversity is produced by an extended gene family conserved in Drosophila and mouse. Science (New York, N.Y.). 248: 599-603. PMID 2333511 DOI: 10.1126/Science.2333511  0.735
1989 Covarrubias M, Kopta C, Steinbach JH. Inhibitors of asparagine-linked oligosaccharide processing alter the kinetics of the nicotinic acetylcholine receptor. The Journal of General Physiology. 93: 765-83. PMID 2525606 DOI: 10.1085/Jgp.93.5.765  0.371
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