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Hardik J. Patel, Ph.D. - Publications

Affiliations: 
2009 St. John's University (New York), School of Pharmacy 
Area:
Pharmaceutical Chemistry, Organic Chemistry, Pharmacology
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22 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Shrestha L, Bolaender A, Patel HJ, Taldone T. Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease. Current Topics in Medicinal Chemistry. PMID 27072696 DOI: 10.2174/1568026616666160413141911  0.35
2015 Patel HJ, Patel PD, Ochiana SO, Yan P, Sun W, Patel MR, Shah SK, Tramentozzi E, Brooks J, Bolaender A, Shrestha L, Stephani R, Finotti P, Leifer C, Li Z, et al. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. Journal of Medicinal Chemistry. 58: 3922-43. PMID 25901531 DOI: 10.1021/Acs.Jmedchem.5B00197  0.65
2015 Yan P, Patel H, Patel P, Ochiana S, Sun W, Shah S, Finotti P, Leifer C, Li Z, Gewirth D, Taldone T, Chiosis G. Abstract 4716: Tumor-specific regulation of receptor tyrosine kinases by Grp94 Cancer Research. 75: 4716-4716. DOI: 10.1158/1538-7445.Am2015-4716  0.326
2015 Ochiana SO, Taldone T, Patel HJ, Patel P, Pengrong Y, Sun W, Rodina A, Shah S, Gewirth DT, Chiosis G. Abstract 2831: Development of selective GRP94 inhibitors for the treatment of cancer Cancer Research. 75: 2831-2831. DOI: 10.1158/1538-7445.Am2015-2831  0.397
2014 Patel S, Liu X, Liu M, Stephani R, Patel H, Cantor J. HJP272, a novel endothelin receptor antagonist, attenuates lipopolysaccharide-induced acute lung injury in hamsters. Lung. 192: 803-10. PMID 25087133 DOI: 10.1007/S00408-014-9628-Z  0.615
2014 Taldone T, Patel HJ, Bolaender A, Patel MR, Chiosis G. Protein chaperones: a composition of matter review (2008 - 2013). Expert Opinion On Therapeutic Patents. 24: 501-18. PMID 24742089 DOI: 10.1517/13543776.2014.887681  0.308
2014 Taldone T, Kang Y, Patel HJ, Patel MR, Patel PD, Rodina A, Patel Y, Gozman A, Maharaj R, Clement CC, Lu A, Young JC, Chiosis G. Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70. Journal of Medicinal Chemistry. 57: 1208-24. PMID 24548239 DOI: 10.1021/Jm401552Y  0.387
2014 Kang Y, Taldone T, Patel HJ, Patel PD, Rodina A, Gozman A, Maharaj R, Clement CC, Patel MR, Brodsky JL, Young JC, Chiosis G. Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. Journal of Medicinal Chemistry. 57: 1188-207. PMID 24548207 DOI: 10.1021/Jm401551N  0.378
2014 Bhagwat N, Koppikar P, Keller M, Marubayashi S, Shank K, Rampal R, Qi J, Kleppe M, Patel HJ, Shah SK, Taldone T, Bradner JE, Chiosis G, Levine RL. Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms. Blood. 123: 2075-83. PMID 24470592 DOI: 10.1182/Blood-2014-01-547760  0.318
2014 Yan P, Patel H, Yang C, Taldone T, Chiosis G. Abstract 3329: Investigations into the tumor specific regulation of HER2 by Grp94 in breast cancer Cancer Research. 74: 3329-3329. DOI: 10.1158/1538-7445.Am2014-3329  0.348
2013 Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, et al. Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. Chemistry & Biology. 20: 1469-80. PMID 24239008 DOI: 10.1016/J.Chembiol.2013.10.008  0.377
2013 Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nature Chemical Biology. 9: 677-84. PMID 23995768 DOI: 10.1038/Nchembio.1335  0.635
2013 Taldone T, Patel PD, Patel M, Patel HJ, Evans CE, Rodina A, Ochiana S, Shah SK, Uddin M, Gewirth D, Chiosis G. Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. Journal of Medicinal Chemistry. 56: 6803-18. PMID 23965125 DOI: 10.1021/Jm400619B  0.352
2013 Taldone T, Rodina A, Dagama Gomes EM, Riolo M, Patel HJ, Alonso-Sabadell R, Zatorska D, Patel MR, Kishinevsky S, Chiosis G. Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes. Beilstein Journal of Organic Chemistry. 9: 544-56. PMID 23616796 DOI: 10.3762/Bjoc.9.60  0.318
2011 Patel HJ, Modi S, Chiosis G, Taldone T. Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment. Expert Opinion On Drug Discovery. 6: 559-587. PMID 22400044 DOI: 10.1517/17460441.2011.563296  0.343
2011 Rodina A, Kang Y, Taldone T, Patel H, Patel P, Caldas-Lopes E, Erdjument-Bromage H, Guzman M, Young JC, Melnick A, Chiosis G. Abstract 2579: YK5, a small molecule inhibitor of Hsp70 and Hsc70, reveals a multifaceted role for the Hsp70 chaperones in regulating oncogenic and non-oncogenic addiction of tumors Cancer Research. 71: 2579-2579. DOI: 10.1158/1538-7445.Am2011-2579  0.364
2010 Patel HJ, Olgun N, Lengyel I, Reznik S, Stephani RA. Synthesis and pharmacological activity of 1,3,6-trisubstituted-4-oxo-1,4-dihydroquinoline-2-carboxylic acids as selective ET(A) antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 6840-4. PMID 20932745 DOI: 10.1016/J.Bmcl.2010.08.074  0.644
2010 Olgun NS, Patel HJ, Stephani R, Lengyel I, Reznik SE. Blockade of endothelin-1 with a novel series of 1,3,6-trisubstituted-2-carboxy-quinol-4-ones controls infection-associated preterm birth. The American Journal of Pathology. 177: 1929-35. PMID 20802183 DOI: 10.2353/Ajpath.2010.100281  0.644
2008 Bhavsar T, Liu XJ, Patel H, Stephani R, Cantor JO. Preferential recruitment of neutrophils by endothelin-1 in acute lung inflammation induced by lipopolysaccharide or cigarette smoke. International Journal of Chronic Obstructive Pulmonary Disease. 3: 477-81. PMID 18990977 DOI: 10.2147/Copd.S2837  0.601
2008 Olgun N, Patel HJ, Stephani R, Wang W, Yen H, Reznik SE. Effect of the putative novel selective ETA-receptor antagonist HJP272, a 1,3,6-trisubstituted-2-carboxy-quinol-4-one, on infection-mediated premature delivery. Canadian Journal of Physiology and Pharmacology. 86: 571-5. PMID 18758506 DOI: 10.1139/Y08-057  0.621
2007 Lengyei I, Patel HJ, Stephani RA. The preparation and characterization of nineteen new phthalidyl spirohydantoins Heterocycles. 73: 349-375. DOI: 10.3987/Com-07-S(U)9  0.607
2006 Patel HJ, Sarra J, Caruso F, Rossi M, Doshi U, Stephani RA. Synthesis and anticonvulsant activity of new N-1',N-3'-disubstituted-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-triones. Bioorganic & Medicinal Chemistry Letters. 16: 4644-7. PMID 16793262 DOI: 10.1016/J.Bmcl.2006.05.102  0.614
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