Year |
Citation |
Score |
2016 |
Shrestha L, Bolaender A, Patel HJ, Taldone T. Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease. Current Topics in Medicinal Chemistry. PMID 27072696 DOI: 10.2174/1568026616666160413141911 |
0.35 |
|
2015 |
Patel HJ, Patel PD, Ochiana SO, Yan P, Sun W, Patel MR, Shah SK, Tramentozzi E, Brooks J, Bolaender A, Shrestha L, Stephani R, Finotti P, Leifer C, Li Z, et al. Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94. Journal of Medicinal Chemistry. 58: 3922-43. PMID 25901531 DOI: 10.1021/Acs.Jmedchem.5B00197 |
0.65 |
|
2015 |
Yan P, Patel H, Patel P, Ochiana S, Sun W, Shah S, Finotti P, Leifer C, Li Z, Gewirth D, Taldone T, Chiosis G. Abstract 4716: Tumor-specific regulation of receptor tyrosine kinases by Grp94 Cancer Research. 75: 4716-4716. DOI: 10.1158/1538-7445.Am2015-4716 |
0.326 |
|
2015 |
Ochiana SO, Taldone T, Patel HJ, Patel P, Pengrong Y, Sun W, Rodina A, Shah S, Gewirth DT, Chiosis G. Abstract 2831: Development of selective GRP94 inhibitors for the treatment of cancer Cancer Research. 75: 2831-2831. DOI: 10.1158/1538-7445.Am2015-2831 |
0.397 |
|
2014 |
Patel S, Liu X, Liu M, Stephani R, Patel H, Cantor J. HJP272, a novel endothelin receptor antagonist, attenuates lipopolysaccharide-induced acute lung injury in hamsters. Lung. 192: 803-10. PMID 25087133 DOI: 10.1007/S00408-014-9628-Z |
0.615 |
|
2014 |
Taldone T, Patel HJ, Bolaender A, Patel MR, Chiosis G. Protein chaperones: a composition of matter review (2008 - 2013). Expert Opinion On Therapeutic Patents. 24: 501-18. PMID 24742089 DOI: 10.1517/13543776.2014.887681 |
0.308 |
|
2014 |
Taldone T, Kang Y, Patel HJ, Patel MR, Patel PD, Rodina A, Patel Y, Gozman A, Maharaj R, Clement CC, Lu A, Young JC, Chiosis G. Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70. Journal of Medicinal Chemistry. 57: 1208-24. PMID 24548239 DOI: 10.1021/Jm401552Y |
0.387 |
|
2014 |
Kang Y, Taldone T, Patel HJ, Patel PD, Rodina A, Gozman A, Maharaj R, Clement CC, Patel MR, Brodsky JL, Young JC, Chiosis G. Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70. Journal of Medicinal Chemistry. 57: 1188-207. PMID 24548207 DOI: 10.1021/Jm401551N |
0.378 |
|
2014 |
Bhagwat N, Koppikar P, Keller M, Marubayashi S, Shank K, Rampal R, Qi J, Kleppe M, Patel HJ, Shah SK, Taldone T, Bradner JE, Chiosis G, Levine RL. Improved targeting of JAK2 leads to increased therapeutic efficacy in myeloproliferative neoplasms. Blood. 123: 2075-83. PMID 24470592 DOI: 10.1182/Blood-2014-01-547760 |
0.318 |
|
2014 |
Yan P, Patel H, Yang C, Taldone T, Chiosis G. Abstract 3329: Investigations into the tumor specific regulation of HER2 by Grp94 in breast cancer Cancer Research. 74: 3329-3329. DOI: 10.1158/1538-7445.Am2014-3329 |
0.348 |
|
2013 |
Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, et al. Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein. Chemistry & Biology. 20: 1469-80. PMID 24239008 DOI: 10.1016/J.Chembiol.2013.10.008 |
0.377 |
|
2013 |
Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nature Chemical Biology. 9: 677-84. PMID 23995768 DOI: 10.1038/Nchembio.1335 |
0.635 |
|
2013 |
Taldone T, Patel PD, Patel M, Patel HJ, Evans CE, Rodina A, Ochiana S, Shah SK, Uddin M, Gewirth D, Chiosis G. Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series. Journal of Medicinal Chemistry. 56: 6803-18. PMID 23965125 DOI: 10.1021/Jm400619B |
0.352 |
|
2013 |
Taldone T, Rodina A, Dagama Gomes EM, Riolo M, Patel HJ, Alonso-Sabadell R, Zatorska D, Patel MR, Kishinevsky S, Chiosis G. Synthesis and evaluation of cell-permeable biotinylated PU-H71 derivatives as tumor Hsp90 probes. Beilstein Journal of Organic Chemistry. 9: 544-56. PMID 23616796 DOI: 10.3762/Bjoc.9.60 |
0.318 |
|
2011 |
Patel HJ, Modi S, Chiosis G, Taldone T. Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment. Expert Opinion On Drug Discovery. 6: 559-587. PMID 22400044 DOI: 10.1517/17460441.2011.563296 |
0.343 |
|
2011 |
Rodina A, Kang Y, Taldone T, Patel H, Patel P, Caldas-Lopes E, Erdjument-Bromage H, Guzman M, Young JC, Melnick A, Chiosis G. Abstract 2579: YK5, a small molecule inhibitor of Hsp70 and Hsc70, reveals a multifaceted role for the Hsp70 chaperones in regulating oncogenic and non-oncogenic addiction of tumors Cancer Research. 71: 2579-2579. DOI: 10.1158/1538-7445.Am2011-2579 |
0.364 |
|
2010 |
Patel HJ, Olgun N, Lengyel I, Reznik S, Stephani RA. Synthesis and pharmacological activity of 1,3,6-trisubstituted-4-oxo-1,4-dihydroquinoline-2-carboxylic acids as selective ET(A) antagonists. Bioorganic & Medicinal Chemistry Letters. 20: 6840-4. PMID 20932745 DOI: 10.1016/J.Bmcl.2010.08.074 |
0.644 |
|
2010 |
Olgun NS, Patel HJ, Stephani R, Lengyel I, Reznik SE. Blockade of endothelin-1 with a novel series of 1,3,6-trisubstituted-2-carboxy-quinol-4-ones controls infection-associated preterm birth. The American Journal of Pathology. 177: 1929-35. PMID 20802183 DOI: 10.2353/Ajpath.2010.100281 |
0.644 |
|
2008 |
Bhavsar T, Liu XJ, Patel H, Stephani R, Cantor JO. Preferential recruitment of neutrophils by endothelin-1 in acute lung inflammation induced by lipopolysaccharide or cigarette smoke. International Journal of Chronic Obstructive Pulmonary Disease. 3: 477-81. PMID 18990977 DOI: 10.2147/Copd.S2837 |
0.601 |
|
2008 |
Olgun N, Patel HJ, Stephani R, Wang W, Yen H, Reznik SE. Effect of the putative novel selective ETA-receptor antagonist HJP272, a 1,3,6-trisubstituted-2-carboxy-quinol-4-one, on infection-mediated premature delivery. Canadian Journal of Physiology and Pharmacology. 86: 571-5. PMID 18758506 DOI: 10.1139/Y08-057 |
0.621 |
|
2007 |
Lengyei I, Patel HJ, Stephani RA. The preparation and characterization of nineteen new phthalidyl spirohydantoins Heterocycles. 73: 349-375. DOI: 10.3987/Com-07-S(U)9 |
0.607 |
|
2006 |
Patel HJ, Sarra J, Caruso F, Rossi M, Doshi U, Stephani RA. Synthesis and anticonvulsant activity of new N-1',N-3'-disubstituted-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-triones. Bioorganic & Medicinal Chemistry Letters. 16: 4644-7. PMID 16793262 DOI: 10.1016/J.Bmcl.2006.05.102 |
0.614 |
|
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