Rachelle Gaudet, Ph.D. - Publications

Molecular and Cellular Biology Harvard University, Cambridge, MA, United States 
Gaudet Structural biology of signaling and transport through biological membranes

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bozzi AT, McCabe AL, Barnett BC, Gaudet R. Transmembrane helix 6b links proton- and metal-release pathways and drives conformational change in an Nramp-family transition metal transporter. The Journal of Biological Chemistry. PMID 31882536 DOI: 10.1074/jbc.RA119.011336  0.6
2019 Bozzi AT, Bane LB, Zimanyi CM, Gaudet R. Unique structural features in an Nramp metal transporter impart substrate-specific proton cotransport and a kinetic bias to favor import. The Journal of General Physiology. PMID 31619456 DOI: 10.1085/jgp.201912428  0.6
2019 Nicoludis JM, Green AG, Walujkar S, May EJ, Sotomayor M, Marks DS, Gaudet R. Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31431536 DOI: 10.1073/pnas.1821063116  0.72
2019 Bozzi AT, Zimanyi CM, Nicoludis JM, Lee BK, Zhang CH, Gaudet R. Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter. Elife. 8. PMID 30714568 DOI: 10.7554/eLife.41124  0.6
2017 Bradshaw N, Levdikov VM, Zimanyi CM, Gaudet R, Wilkinson AJ, Losick R. A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases. Elife. 6. PMID 28527238 DOI: 10.7554/eLife.26111  0.32
2017 Powers RE, Gaudet R, Sotomayor M. A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15. Structure (London, England : 1993). PMID 28238533 DOI: 10.1016/j.str.2017.01.014  0.72
2016 Bozzi AT, Bane LB, Weihofen WA, Singharoy A, Guillen ER, Ploegh HL, Schulten K, Gaudet R. Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter. Structure (London, England : 1993). PMID 27839948 DOI: 10.1016/j.str.2016.09.017  0.72
2016 Bozzi AT, Bane LB, Weihofen WA, McCabe AL, Singharoy A, Chipot CJ, Schulten K, Gaudet R. Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573840 DOI: 10.1073/pnas.1607734113  0.72
2016 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, ... ... Gaudet R, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/ncomms10882  1
2015 Sullivan JM, Zimanyi CM, Aisenberg W, Bears B, Chen DH, Day JW, Bird TD, Siskind CE, Gaudet R, Sumner CJ. Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy. Neurology. Genetics. 1: e29. PMID 27066566 DOI: 10.1212/NXG.0000000000000029  0.32
2015 Nicoludis JM, Lau SY, Schärfe CP, Marks DS, Weihofen WA, Gaudet R. Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity. Structure (London, England : 1993). 23: 2087-98. PMID 26481813 DOI: 10.1016/j.str.2015.09.005  1
2015 Brewster MS, Gaudet R. How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 1184-92. PMID 26387779 DOI: 10.1002/bies.201500085  1
2015 Knecht ZA, Gaudet R, Garrity PA. The Touching Tail of a Mechanotransduction Channel. Cell. 162: 1214-6. PMID 26359983 DOI: 10.1016/j.cell.2015.08.049  1
2015 Gaudet R, Roux B, Minor DL. Insights into the molecular foundations of electrical excitation. Journal of Molecular Biology. 427: 1-2. PMID 25542854 DOI: 10.1016/j.jmb.2014.12.006  1
2015 Sysoeva TA, Bane LB, Xiao DY, Bose B, Chilton SS, Gaudet R, Burton BM. Structural characterization of the late competence protein ComFB from Bacillus subtilis. Bioscience Reports. 35. PMID 25423369 DOI: 10.1042/BSR20140174  1
2014 Sullivan JM, Landouré G, Gaudet R, Sumner CJ. Phenotypic spectrum and incidence of TRPV4 mutations in patients with inherited axonal neuropathy. Neurology. 83: 1991. PMID 25404646 DOI: 10.1212/WNL.0000000000001041  1
2014 Grossmann N, Vakkasoglu AS, Hulpke S, Abele R, Gaudet R, Tampé R. Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter. Nature Communications. 5: 5419. PMID 25377891 DOI: 10.1038/ncomms6419  1
2014 Hellmich UA, Gaudet R. High-resolution views of TRPV1 and their implications for the TRP channel superfamily. Handbook of Experimental Pharmacology. 223: 991-1004. PMID 24961977 DOI: 10.1007/978-3-319-05161-1_11  1
2014 Hellmich UA, Gaudet R. Structural biology of TRP channels. Handbook of Experimental Pharmacology. 223: 963-90. PMID 24961976 DOI: 10.1007/978-3-319-05161-1_10  1
2014 Sotomayor M, Gaudet R, Corey DP. Sorting out a promiscuous superfamily: towards cadherin connectomics. Trends in Cell Biology. 24: 524-36. PMID 24794279 DOI: 10.1016/j.tcb.2014.03.007  1
2013 Garcia-Elias A, Mrkonjic S, Pardo-Pastor C, Inada H, Hellmich UA, Rubio-Moscardó F, Plata C, Gaudet R, Vicente R, Valverde MA. Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Proceedings of the National Academy of Sciences of the United States of America. 110: 9553-8. PMID 23690576 DOI: 10.1073/pnas.1220231110  1
2013 Perálvarez-Marín A, Doñate-Macian P, Gaudet R. What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? The Febs Journal. 280: 5471-87. PMID 23615321 DOI: 10.1111/febs.12302  1
2013 Geng R, Sotomayor M, Kinder KJ, Gopal SR, Gerka-Stuyt J, Chen DH, Hardisty-Hughes RE, Ball G, Parker A, Gaudet R, Furness D, Brown SD, Corey DP, Alagramam KN. Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4395-404. PMID 23467356 DOI: 10.1523/JNEUROSCI.4514-12.2013  1
2012 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction. Nature. 492: 128-32. PMID 23135401 DOI: 10.1038/nature11590  1
2012 Lau SY, Procko E, Gaudet R. Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel. The Journal of General Physiology. 140: 541-55. PMID 23109716 DOI: 10.1085/jgp.201210810  1
2012 Inada H, Procko E, Sotomayor M, Gaudet R. Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry. 51: 6195-206. PMID 22702953 DOI: 10.1021/bi300279b  1
2012 Landouré G, Sullivan JM, Johnson JO, Munns CH, Shi Y, Diallo O, Gibbs JR, Gaudet R, Ludlow CL, Fischbeck KH, Traynor BJ, Burnett BG, Sumner CJ. Exome sequencing identifies a novel TRPV4 mutation in a CMT2C family. Neurology. 79: 192-4. PMID 22675077 DOI: 10.1212/WNL.0b013e31825f04b2  1
2011 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Molecular mechanics of tip-link cadherins Aip Conference Proceedings. 1403: 64-69. DOI: 10.1063/1.3658062  1
2010 Zimo? M, Baets J, Auer-Grumbach M, Berciano J, Garcia A, Lopez-Laso E, Merlini L, Hilton-Jones D, McEntagart M, Crosby AH, Barisic N, Boltshauser E, Shaw CE, Landouré G, Ludlow CL, ... Gaudet R, et al. Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies. Brain : a Journal of Neurology. 133: 1798-809. PMID 20460441 DOI: 10.1093/brain/awq109  1
2010 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Structural determinants of cadherin-23 function in hearing and deafness. Neuron. 66: 85-100. PMID 20399731 DOI: 10.1016/j.neuron.2010.03.028  1
2010 Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL. Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. The Journal of Biological Chemistry. 285: 6857-66. PMID 20042598 DOI: 10.1074/jbc.M109.072405  1
2010 Landouré G, Zdebik AA, Martinez TL, Burnett BG, Stanescu HC, Inada H, Shi Y, Taye AA, Kong L, Munns CH, Choo SS, Phelps CB, Paudel R, Houlden H, Ludlow CL, ... ... Gaudet R, et al. Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nature Genetics. 42: 170-4. PMID 20037586 DOI: 10.1038/ng.512  1
2010 Phelps CB, Wang RR, Choo SS, Gaudet R. Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. The Journal of Biological Chemistry. 285: 731-40. PMID 19864432 DOI: 10.1074/jbc.M109.052548  1
2009 Procko E, Gaudet R. Antigen processing and presentation: TAPping into ABC transporters. Current Opinion in Immunology. 21: 84-91. PMID 19261456 DOI: 10.1016/j.coi.2009.02.003  1
2009 Gaudet R. Divide and conquer: high resolution structural information on TRP channel fragments. The Journal of General Physiology. 133: 231-7. PMID 19237587 DOI: 10.1085/jgp.200810137  1
2009 Procko E, O'Mara ML, Bennett WF, Tieleman DP, Gaudet R. The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 1287-302. PMID 19174475 DOI: 10.1096/fj.08-121855  1
2008 Gaudet R. The ABCs of trans(porter) inhibition. Nature Chemical Biology. 4: 454-5. PMID 18641624 DOI: 10.1038/nchembio0808-454  1
2008 Gaudet R. TRP channels entering the structural era. The Journal of Physiology. 586: 3565-75. PMID 18535090 DOI: 10.1113/jphysiol.2008.155812  1
2008 Procko E, Gaudet R. Functionally important interactions between the nucleotide-binding domains of an antigenic peptide transporter. Biochemistry. 47: 5699-708. PMID 18452308 DOI: 10.1021/bi7024854  1
2008 Gaudet R. A primer on ankyrin repeat function in TRP channels and beyond. Molecular Biosystems. 4: 372-9. PMID 18414734 DOI: 10.1039/b801481g  1
2008 Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R. Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry. 47: 2476-84. PMID 18232717 DOI: 10.1021/bi702109w  1
2007 Phelps CB, Procko E, Lishko PV, Wang RR, Gaudet R. Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels. Channels (Austin, Tex.). 1: 148-51. PMID 18690026  1
2007 Phelps CB, Gaudet R. The role of the N terminus and transmembrane domain of TRPM8 in channel localization and tetramerization. The Journal of Biological Chemistry. 282: 36474-80. PMID 17908685 DOI: 10.1074/jbc.M707205200  1
2007 Lishko PV, Procko E, Jin X, Phelps CB, Gaudet R. The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron. 54: 905-18. PMID 17582331 DOI: 10.1016/j.neuron.2007.05.027  1
2007 Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL. Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Molecular Cell. 25: 677-87. PMID 17349955 DOI: 10.1016/j.molcel.2007.01.033  1
2006 Procko E, Ferrin-O'Connell I, Ng SL, Gaudet R. Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter. Molecular Cell. 24: 51-62. PMID 17018292 DOI: 10.1016/j.molcel.2006.07.034  1
2006 Jin X, Touhey J, Gaudet R. Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. The Journal of Biological Chemistry. 281: 25006-10. PMID 16809337 DOI: 10.1074/jbc.C600153200  1
2005 Procko E, Raghuraman G, Wiley DC, Raghavan M, Gaudet R. Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I. Immunology and Cell Biology. 83: 475-82. PMID 16174096 DOI: 10.1111/j.1440-1711.2005.01354.x  1
2005 Misaghi S, Galardy PJ, Meester WJ, Ovaa H, Ploegh HL, Gaudet R. Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. The Journal of Biological Chemistry. 280: 1512-20. PMID 15531586 DOI: 10.1074/jbc.M410770200  1
2004 Misaghi S, Sun ZY, Stern P, Gaudet R, Wagner G, Ploegh H. Structural and functional analysis of human cytomegalovirus US3 protein. Journal of Virology. 78: 413-23. PMID 14671122 DOI: 10.1128/JVI.78.1.413-423.2004  1
2002 Obin M, Lee BY, Meinke G, Bohm A, Lee RH, Gaudet R, Hopp JA, Arshavsky VY, Willardson BM, Taylor A. Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin. The Journal of Biological Chemistry. 277: 44566-75. PMID 12215439 DOI: 10.1074/jbc.M205308200  1
2001 Gaudet R, Wiley DC. Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing. The Embo Journal. 20: 4964-72. PMID 11532960 DOI: 10.1093/emboj/20.17.4964  1
2001 Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL. Virus subversion of immunity: a structural perspective. Current Opinion in Immunology. 13: 442-50. PMID 11498300 DOI: 10.1016/S0952-7915(00)00239-9  1
2001 Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL, Wiley DC. Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2. Proceedings of the National Academy of Sciences of the United States of America. 98: 6794-9. PMID 11391001 DOI: 10.1073/pnas.121172898  1
2001 Holm M, Hardtke CS, Gaudet R, Deng XW. Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1. The Embo Journal. 20: 118-27. PMID 11226162 DOI: 10.1093/emboj/20.1.118  1
1999 Gaudet R, Savage JR, McLaughlin JN, Willardson BM, Sigler PB. A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin. Molecular Cell. 3: 649-60. PMID 10360181 DOI: 10.1016/S1097-2765(00)80358-5  1
1997 Bohm A, Gaudet R, Sigler PB. Structural aspects of heterotrimeric G-protein signaling. Current Opinion in Biotechnology. 8: 480-7. PMID 9265729 DOI: 10.1016/S0958-1669(97)80072-9  1
1996 Gaudet R, Bohm A, Sigler PB. Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin. Cell. 87: 577-88. PMID 8898209 DOI: 10.1016/S0092-8674(00)81376-8  1
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