Timothy H. Murphy, Ph.D. - Publications

Affiliations: 
Neuroscience University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Stroke, Vascular System, Dendritic Plasticity, Oxidative Stress
Website:
http://www.neuroscience.ubc.ca/faculty/murphy.html

145 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Michelson NJ, Bolaños F, Bolaños LA, Balbi M, LeDue JM, Murphy TH. Meso-py: Dual brain cortical calcium imaging in mice during head-fixed social stimulus presentation. Eneuro. PMID 38053472 DOI: 10.1523/ENEURO.0096-23.2023  0.821
2023 Xiao D, Yan Y, Murphy TH. Mesotrode chronic simultaneous mesoscale cortical imaging and subcortical or peripheral nerve spiking activity recording in mice. Elife. 12. PMID 37962180 DOI: 10.7554/eLife.87691  0.367
2023 Fong T, Hu H, Gupta P, Jury B, Murphy TH. PyMouseTracks: flexible computer vision and RFID based system for multiple mouse tracking and behavioral assessment. Eneuro. PMID 37185293 DOI: 10.1523/ENEURO.0127-22.2023  0.368
2023 Ramandi D, Michelson NJ, Raymond LA, Murphy TH. Chronic multiscale resolution of mouse brain networks using combined mesoscale cortical imaging and subcortical fiber photometry. Neurophotonics. 10: 015001. PMID 36694618 DOI: 10.1117/1.NPh.10.1.015001  0.815
2022 Sepers MD, Mackay JP, Koch E, Xiao D, Mohajerani MH, Chan AW, Smith-Dijak AI, Ramandi D, Murphy TH, Raymond LA. Altered cortical processing of sensory input in Huntington disease mouse models. Neurobiology of Disease. 169: 105740. PMID 35460870 DOI: 10.1016/j.nbd.2022.105740  0.735
2021 Xiao D, Forys BJ, Vanni MP, Murphy TH. MesoNet allows automated scaling and segmentation of mouse mesoscale cortical maps using machine learning. Nature Communications. 12: 5992. PMID 34645817 DOI: 10.1038/s41467-021-26255-2  0.792
2021 Bolaños LA, Xiao D, Ford NL, LeDue JM, Gupta PK, Doebeli C, Hu H, Rhodin H, Murphy TH. A three-dimensional virtual mouse generates synthetic training data for behavioral analysis. Nature Methods. PMID 33820989 DOI: 10.1038/s41592-021-01103-9  0.315
2021 Balbi M, Xiao D, Jativa Vega M, Hu H, Vanni MP, Bernier LP, LeDue J, MacVicar B, Murphy TH. Gamma frequency activation of inhibitory neurons in the acute phase after stroke attenuates vascular and behavioral dysfunction. Cell Reports. 34: 108696. PMID 33535035 DOI: 10.1016/j.celrep.2021.108696  0.723
2020 Murphy TH, Michelson NJ, Boyd JD, Fong T, Bolanos LA, Bierbrauer D, Siu T, Balbi M, Bolanos F, Vanni M, LeDue JM. Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages. Elife. 9. PMID 32412409 DOI: 10.7554/Elife.55964  0.797
2020 Forys BJ, Xiao D, Gupta P, Murphy TH. Real-time selective markerless tracking of forepaws of head fixed mice using deep neural networks. Eneuro. PMID 32409507 DOI: 10.1523/ENEURO.0096-20.2020  0.772
2020 McGirr A, LeDue J, Chan AW, Boyd JD, Metzak PD, Murphy TH. Stress impacts sensory variability through cortical sensory activity motifs. Translational Psychiatry. 10: 20. PMID 32066714 DOI: 10.1038/S41398-020-0713-1  0.728
2020 Murphy TH, Michelson NJ, Boyd JD, Fong T, Bolanos LA, Bierbrauer D, Siu T, Balbi M, Bolanos F, Vanni M, LeDue JM. Author response: Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages Elife. DOI: 10.7554/Elife.55964.Sa2  0.771
2019 Michelson NJ, Vanni MP, Murphy TH. Comparison between transgenic and AAV-PHP.eB-mediated expression of GCaMP6s using wide-field functional imaging of brain activity. Neurophotonics. 6: 025014. PMID 31763351 DOI: 10.1117/1.Nph.6.2.025014  0.792
2019 Gupta PK, Murphy TH. Cortex-wide Computations in Complex Decision Making in Mice. Neuron. 104: 631-633. PMID 31751543 DOI: 10.1016/J.Neuron.2019.10.043  0.539
2019 Ashby DM, LeDue J, Murphy TH, McGirr A. Peripheral Nerve Ligation Elicits Widespread Alterations in Cortical Sensory Evoked and Spontaneous Activity. Scientific Reports. 9: 15341. PMID 31653941 DOI: 10.1038/S41598-019-51811-8  0.69
2019 Mitelut CC, Spacek MA, Chan AW, Murphy TH, Swindale NV. LFP clustering in cortex reveals a taxonomy of UP-states and near-millisecond, ordered phase-locking in cortical neurons. Journal of Neurophysiology. PMID 31433725 DOI: 10.1152/Jn.00456.2019  0.55
2019 Cait J, Hughes MR, Zeglinski MR, Chan AW, Osterhof S, Scott RW, Canals Hernaez D, Cait A, Vogl AW, Bernatchez P, Underhill TM, Granville DJ, Murphy TH, Roskelley CD, McNagny KM. Podocalyxin is required for maintaining blood-brain barrier function during acute inflammation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30787191 DOI: 10.1073/Pnas.1814766116  0.535
2019 Murphy TH. High-Throughput Electrophysiological, Behavioral, or Social Event Triggered Imaging of Mouse Mesoscale Brain Activity Brain. DOI: 10.1364/Brain.2019.Bm2A.1  0.346
2018 Balbi M, Vanni MP, Vega MJ, Silasi G, Sekino Y, Boyd JD, LeDue JM, Murphy TH. Longitudinal monitoring of mesoscopic cortical activity in a mouse model of microinfarcts reveals dissociations with behavioral and motor function. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18763428. PMID 29521138 DOI: 10.1177/0271678X18763428  0.816
2017 Chan AW, Murphy TH. Good Vibrations: Resting-State Functional Connectivity Reflects Entrainment of Vasomotion. Neuron. 96: 716-717. PMID 29144969 DOI: 10.1016/J.Neuron.2017.10.035  0.539
2017 Silasi G, Boyd J, Bolanos F, LeDue J, Scott SH, Murphy TH. Individualized tracking of self-directed motor learning in group-housed mice performing a skilled lever positioning task in the home cage. Journal of Neurophysiology. jn.00115.2017. PMID 29070625 DOI: 10.1152/Jn.00115.2017  0.704
2017 Woodard CL, Bolaños F, Boyd JD, Silasi G, Murphy TH, Raymond LA. An Automated Home-Cage System to Assess Learning and Performance of a Skilled Motor Task in a Mouse Model of Huntington's Disease. Eneuro. 4. PMID 28929129 DOI: 10.1523/ENEURO.0141-17.2017  0.678
2017 McGirr A, LeDue J, Chan AW, Xie Y, Murphy TH. Cortical functional hyperconnectivity in a mouse model of depression and selective network effects of ketamine. Brain : a Journal of Neurology. 140: 2210-2225. PMID 28899017 DOI: 10.1093/Brain/Awx142  0.748
2017 Balbi M, Vanni MP, Silasi G, Sekino Y, Bolanos L, LeDue JM, Murphy TH. Targeted ischemic stroke induction and mesoscopic imaging assessment of blood flow and ischemic depolarization in awake mice. Neurophotonics. 4: 035001. PMID 28721356 DOI: 10.1117/1.Nph.4.3.035001  0.791
2017 Vanni MP, Chan AW, Balbi M, Silasi G, Murphy TH. Mesoscale mapping of mouse cortex reveals frequency-dependent cycling between distinct macroscale functional modules. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28674167 DOI: 10.1523/Jneurosci.3560-16.2017  0.82
2017 Haupt D, Vanni MP, Bolanos F, Mitelut C, LeDue JM, Murphy TH. Mesoscale brain explorer, a flexible python-based image analysis and visualization tool. Neurophotonics. 4: 031210. PMID 28560240 DOI: 10.1117/1.Nph.4.3.031210  0.745
2017 Xiao D, Vanni MP, Mitelut CC, Chan AW, LeDue JM, Xie Y, Chen AC, Swindale NV, Murphy TH. Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons. Elife. 6. PMID 28160463 DOI: 10.7554/Elife.19976  0.82
2017 Xiao D, Vanni MP, Mitelut CC, Chan AW, LeDue JM, Xie Y, Chen AC, Swindale NV, Murphy TH. Author response: Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons Elife. DOI: 10.7554/Elife.19976.035  0.805
2016 McVea DA, Murphy TH, Mohajerani MH. Large Scale Cortical Functional Networks Associated with Slow-Wave and Spindle-Burst-Related Spontaneous Activity. Frontiers in Neural Circuits. 10: 103. PMID 28066190 DOI: 10.3389/Fncir.2016.00103  0.675
2016 Hefendehl JK, LeDue J, Ko RW, Mahler J, Murphy TH, MacVicar BA. Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging. Nature Communications. 7: 13441. PMID 27834383 DOI: 10.1038/Ncomms13441  0.376
2016 Connor SA, Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Kurihara N, Tada A, Ge Y, Lu H, Yan R, LeDue JM, Matsumoto H, Kiyonari H, Kirino Y, Matsuzaki F, ... ... Murphy TH, et al. Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2. Neuron. 91: 1052-68. PMID 27608760 DOI: 10.1016/J.Neuron.2016.08.016  0.73
2016 Murphy TH, Boyd JD, Bolaños F, Vanni MP, Silasi G, Haupt D, LeDue JM. High-throughput automated home-cage mesoscopic functional imaging of mouse cortex. Nature Communications. 7: 11611. PMID 27291514 DOI: 10.1038/Ncomms11611  0.81
2016 Silasi G, Xiao D, Vanni MP, Chen AC, Murphy TH. Intact skull chronic windows for mesoscopic wide-field imaging in awake mice. Journal of Neuroscience Methods. PMID 27102043 DOI: 10.1016/J.Jneumeth.2016.04.012  0.793
2016 Hilton BJ, Anenberg E, Harrison TC, Boyd JD, Murphy TH, Tetzlaff W. Re-Establishment of Cortical Motor Output Maps and Spontaneous Functional Recovery via Spared Dorsolaterally Projecting Corticospinal Neurons after Dorsal Column Spinal Cord Injury in Adult Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 4080-92. PMID 27053214 DOI: 10.1523/Jneurosci.3386-15.2016  0.679
2016 Parsons MP, Vanni MP, Woodard CL, Kang R, Murphy TH, Raymond LA. Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models. Nature Communications. 7: 11251. PMID 27052848 DOI: 10.1038/Ncomms11251  0.707
2016 Xie Y, Chan AW, McGirr A, Xue S, Xiao D, Zeng H, Murphy TH. Resolution of High-Frequency Mesoscale Intracortical Maps Using the Genetically Encoded Glutamate Sensor iGluSnFR. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1261-72. PMID 26818514 DOI: 10.1523/Jneurosci.2744-15.2016  0.768
2015 Lacroix A, Toussay X, Anenberg E, Lecrux C, Ferreirós N, Karagiannis A, Plaisier F, Chausson P, Jarlier F, Burgess SA, Hillman EM, Tegeder I, Murphy TH, Hamel E, Cauli B. COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11791-810. PMID 26311764 DOI: 10.1523/Jneurosci.0651-15.2015  0.384
2015 Funayama K, Minamisawa G, Matsumoto N, Ban H, Chan AW, Matsuki N, Murphy TH, Ikegaya Y. Neocortical Rebound Depolarization Enhances Visual Perception. Plos Biology. 13: e1002231. PMID 26274866 DOI: 10.1371/Journal.Pbio.1002231  0.525
2015 Chan AW, Mohajerani MH, LeDue JM, Wang YT, Murphy TH. Mesoscale infraslow spontaneous membrane potential fluctuations recapitulate high-frequency activity cortical motifs. Nature Communications. 6: 7738. PMID 26190168 DOI: 10.1038/Ncomms8738  0.797
2015 Lim DH, LeDue JM, Murphy TH. Network analysis of mesoscale optical recordings to assess regional, functional connectivity. Neurophotonics. 2: 041405. PMID 26158019 DOI: 10.1117/1.Nph.2.4.041405  0.558
2015 Anenberg E, Chan AW, Xie Y, LeDue JM, Murphy TH. Optogenetic stimulation of GABA neurons can decrease local neuronal activity while increasing cortical blood flow. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26082013 DOI: 10.1038/Jcbfm.2015.140  0.677
2015 Murphy TH. Two-Photon Imaging of Neuronal Structural Plasticity in Mice during and after Ischemia. Cold Spring Harbor Protocols. 2015: pdb.prot087486. PMID 26034310 DOI: 10.1101/Pdb.Prot087486  0.383
2015 Silasi G, She J, Boyd JD, Xue S, Murphy TH. A mouse model of small-vessel disease that produces brain-wide-identified microocclusions and regionally selective neuronal injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 734-8. PMID 25690472 DOI: 10.1038/Jcbfm.2015.8  0.72
2015 Vanni MP, Chan A, Xiao D, Silasi G, Moshevand M, Ledue J, Murphy TH. Cortical activity motifs that correspond to sensory modalities are organized within larger superclusters Optics and the Brain, Brain 2015. DOI: 10.1364/Brain.2015.Brt2B.3  0.806
2015 Murphy TH. Point-source Maps: Relations between Mesoscopic Imaging of Mouse Cortex and Neuronal Spiking Brain. DOI: 10.1364/Brain.2015.Brt2B.1  0.447
2014 Lim DH, LeDue JM, Mohajerani MH, Murphy TH. Optogenetic mapping after stroke reveals network-wide scaling of functional connections and heterogeneous recovery of the peri-infarct. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 16455-66. PMID 25471583 DOI: 10.1523/Jneurosci.3384-14.2014  0.716
2014 Vanni MP, Murphy TH. Mesoscale transcranial spontaneous activity mapping in GCaMP3 transgenic mice reveals extensive reciprocal connections between areas of somatomotor cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15931-46. PMID 25429135 DOI: 10.1523/Jneurosci.1818-14.2014  0.782
2014 Xie Y, Chen S, Wu Y, Murphy TH. Prolonged deficits in parvalbumin neuron stimulation-evoked network activity despite recovery of dendritic structure and excitability in the somatosensory cortex following global ischemia in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 14890-900. PMID 25378156 DOI: 10.1523/Jneurosci.1775-14.2014  0.57
2014 Silasi G, Murphy TH. Stroke and the connectome: how connectivity guides therapeutic intervention. Neuron. 83: 1354-68. PMID 25233317 DOI: 10.1016/J.Neuron.2014.08.052  0.724
2014 Silasi G, Murphy TH. Removing the brakes on post-stroke plasticity drives recovery from the intact hemisphere and spinal cord. Brain : a Journal of Neurology. 137: 648-50. PMID 24549809 DOI: 10.1093/Brain/Awu016  0.72
2014 Harrison TC, Murphy TH. Motor maps and the cortical control of movement. Current Opinion in Neurobiology. 24: 88-94. PMID 24492084 DOI: 10.1016/J.Conb.2013.08.018  0.676
2014 Anenberg E, Arstikaitis P, Niitsu Y, Harrison TC, Boyd JD, Hilton BJ, Tetzlaff W, Murphy TH. Ministrokes in channelrhodopsin-2 transgenic mice reveal widespread deficits in motor output despite maintenance of cortical neuronal excitability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1094-104. PMID 24453302 DOI: 10.1523/Jneurosci.1442-13.2014  0.686
2014 Reimers MA, Mohajerani M, Murphy TH. A dynamic model for delta rhythm fit to high-frequency cortical activity data shows discrete functional connectivity in mouse cortex Bmc Neuroscience. 15. DOI: 10.1186/1471-2202-15-S1-P82  0.679
2013 Mohajerani MH, Chan AW, Mohsenvand M, LeDue J, Liu R, McVea DA, Boyd JD, Wang YT, Reimers M, Murphy TH. Spontaneous cortical activity alternates between motifs defined by regional axonal projections. Nature Neuroscience. 16: 1426-35. PMID 23974708 DOI: 10.1038/Nn.3499  0.791
2013 Silasi G, Boyd JD, Ledue J, Murphy TH. Improved methods for chronic light-based motor mapping in mice: automated movement tracking with accelerometers, and chronic EEG recording in a bilateral thin-skull preparation. Frontiers in Neural Circuits. 7: 123. PMID 23966910 DOI: 10.3389/Fncir.2013.00123  0.728
2013 Harrison TC, Silasi G, Boyd JD, Murphy TH. Displacement of sensory maps and disorganization of motor cortex after targeted stroke in mice. Stroke; a Journal of Cerebral Circulation. 44: 2300-6. PMID 23743973 DOI: 10.1161/Strokeaha.113.001272  0.808
2013 Xie Y, Chen S, Anenberg E, Murphy TH. Resistance of optogenetically evoked motor function to global ischemia and reperfusion in mouse in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1148-52. PMID 23736644 DOI: 10.1038/Jcbfm.2013.89  0.516
2013 Lim DH, Ledue J, Mohajerani MH, Vanni MP, Murphy TH. Optogenetic approaches for functional mouse brain mapping. Frontiers in Neuroscience. 7: 54. PMID 23596383 DOI: 10.3389/Fnins.2013.00054  0.82
2013 Reimers M, Mohajerani M, Murphy TH. A model for delta rhythm fit to high-frequency cortical activity data Bmc Neuroscience. 14. DOI: 10.1186/1471-2202-14-S1-P287  0.652
2012 Harrison TC, Murphy TH. Towards a circuit mechanism for movement tuning in motor cortex. Frontiers in Neural Circuits. 6: 127. PMID 23346050 DOI: 10.3389/Fncir.2012.00127  0.686
2012 Chen S, Mohajerani MH, Xie Y, Murphy TH. Optogenetic analysis of neuronal excitability during global ischemia reveals selective deficits in sensory processing following reperfusion in mouse cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13510-9. PMID 23015440 DOI: 10.1523/Jneurosci.1439-12.2012  0.731
2012 McVea DA, Mohajerani MH, Murphy TH. Voltage-sensitive dye imaging reveals dynamic spatiotemporal properties of cortical activity after spontaneous muscle twitches in the newborn rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10982-94. PMID 22875932 DOI: 10.1523/Jneurosci.1322-12.2012  0.701
2012 Xie Y, Chen S, Murphy T. Dendritic spines and pre-synaptic boutons are stable despite local deep hypothermic challenge and re-warming in vivo. Plos One. 7: e36305. PMID 22563488 DOI: 10.1371/Journal.Pone.0036305  0.531
2012 Harrison TC, Ayling OG, Murphy TH. Distinct cortical circuit mechanisms for complex forelimb movement and motor map topography. Neuron. 74: 397-409. PMID 22542191 DOI: 10.1016/J.Neuron.2012.02.028  0.675
2012 Lim DH, Mohajerani MH, Ledue J, Boyd J, Chen S, Murphy TH. In vivo Large-Scale Cortical Mapping Using Channelrhodopsin-2 Stimulation in Transgenic Mice Reveals Asymmetric and Reciprocal Relationships between Cortical Areas. Frontiers in Neural Circuits. 6: 11. PMID 22435052 DOI: 10.3389/Fncir.2012.00011  0.762
2012 Scott NA, Murphy TH. Hemodynamic responses evoked by neuronal stimulation via channelrhodopsin-2 can be independent of intracortical glutamatergic synaptic transmission. Plos One. 7: e29859. PMID 22253807 DOI: 10.1371/Journal.Pone.0029859  0.399
2012 Tran S, Chen S, Liu RR, Xie Y, Murphy TH. Moderate or deep local hypothermia does not prevent the onset of ischemia-induced dendritic damage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 437-42. PMID 22167237 DOI: 10.1038/Jcbfm.2011.178  0.496
2011 Mohajerani MH, Aminoltejari K, Murphy TH. Targeted mini-strokes produce changes in interhemispheric sensory signal processing that are indicative of disinhibition within minutes. Proceedings of the National Academy of Sciences of the United States of America. 108: E183-91. PMID 21576480 DOI: 10.1073/Pnas.1101914108  0.653
2011 Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH, Craig AM. Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex. Neuron. 69: 287-303. PMID 21262467 DOI: 10.1016/J.Neuron.2010.12.024  0.666
2011 Chen S, Tran S, Sigler A, Murphy TH. Automated and quantitative image analysis of ischemic dendritic blebbing using in vivo 2-photon microscopy data. Journal of Neuroscience Methods. 195: 222-31. PMID 21184780 DOI: 10.1016/J.Jneumeth.2010.12.018  0.376
2011 Scott NA, Murphy TH. Glial laminar cortical architecture matches metabolic demand. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 793-4. PMID 21139627 DOI: 10.1038/Jcbfm.2010.205  0.309
2011 Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH, Craig AM. Identification of the TrkC/PTPσ trans-synaptic complex as a bidirectional excitatory synaptic organizer Neuroscience Research. 71: e17. DOI: 10.1016/J.Neures.2011.07.070  0.524
2010 Sigler A, Murphy TH. In vivo 2-photon imaging of fine structure in the rodent brain: before, during, and after stroke. Stroke; a Journal of Cerebral Circulation. 41: S117-23. PMID 20876484 DOI: 10.1161/Strokeaha.110.594648  0.354
2010 Mohajerani MH, McVea DA, Fingas M, Murphy TH. Mirrored bilateral slow-wave cortical activity within local circuits revealed by fast bihemispheric voltage-sensitive dye imaging in anesthetized and awake mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3745-51. PMID 20220008 DOI: 10.1523/Jneurosci.6437-09.2010  0.684
2010 Milnerwood AJ, Gladding CM, Pouladi MA, Kaufman AM, Hines RM, Boyd JD, Ko RW, Vasuta OC, Graham RK, Hayden MR, Murphy TH, Raymond LA. Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice. Neuron. 65: 178-90. PMID 20152125 DOI: 10.1016/J.Neuron.2010.01.008  0.347
2010 Brown CE, Boyd JD, Murphy TH. Longitudinal in vivo imaging reveals balanced and branch-specific remodeling of mature cortical pyramidal dendritic arbors after stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 783-91. PMID 19920846 DOI: 10.1038/Jcbfm.2009.241  0.567
2009 Liu RR, Murphy TH. Reversible cyclosporin A-sensitive mitochondrial depolarization occurs within minutes of stroke onset in mouse somatosensory cortex in vivo: a two-photon imaging study. The Journal of Biological Chemistry. 284: 36109-17. PMID 19892710 DOI: 10.1074/Jbc.M109.055301  0.341
2009 Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nature Reviews. Neuroscience. 10: 861-72. PMID 19888284 DOI: 10.1038/Nrn2735  0.352
2009 Winship IR, Murphy TH. Remapping the somatosensory cortex after stroke: insight from imaging the synapse to network. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 15: 507-24. PMID 19622841 DOI: 10.1177/1073858409333076  0.417
2009 Sigler A, Mohajerani MH, Murphy TH. Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 11759-64. PMID 19571005 DOI: 10.1073/Pnas.0812695106  0.697
2009 Harrison TC, Sigler A, Murphy TH. Simple and cost-effective hardware and software for functional brain mapping using intrinsic optical signal imaging. Journal of Neuroscience Methods. 182: 211-8. PMID 19559049 DOI: 10.1016/J.Jneumeth.2009.06.021  0.643
2009 Ayling OG, Harrison TC, Boyd JD, Goroshkov A, Murphy TH. Automated light-based mapping of motor cortex by photoactivation of channelrhodopsin-2 transgenic mice. Nature Methods. 6: 219-24. PMID 19219033 DOI: 10.1038/Nmeth.1303  0.684
2009 Brown CE, Aminoltejari K, Erb H, Winship IR, Murphy TH. In vivo voltage-sensitive dye imaging in adult mice reveals that somatosensory maps lost to stroke are replaced over weeks by new structural and functional circuits with prolonged modes of activation within both the peri-infarct zone and distant sites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1719-34. PMID 19211879 DOI: 10.1523/Jneurosci.4249-08.2009  0.612
2008 Li P, Murphy TH. Two-photon imaging during prolonged middle cerebral artery occlusion in mice reveals recovery of dendritic structure after reperfusion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11970-9. PMID 19005062 DOI: 10.1523/Jneurosci.3724-08.2008  0.341
2008 Winship IR, Murphy TH. In vivo calcium imaging reveals functional rewiring of single somatosensory neurons after stroke. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6592-606. PMID 18579732 DOI: 10.1523/Jneurosci.0622-08.2008  0.435
2008 Brown CE, Wong C, Murphy TH. Rapid morphologic plasticity of peri-infarct dendritic spines after focal ischemic stroke. Stroke; a Journal of Cerebral Circulation. 39: 1286-91. PMID 18323506 DOI: 10.1161/Strokeaha.107.498238  0.578
2008 Arstikaitis P, Gauthier-Campbell C, Carolina Gutierrez Herrera R, Huang K, Levinson JN, Murphy TH, Kilimann MW, Sala C, Colicos MA, El-Husseini A. Paralemmin-1, a modulator of filopodia induction is required for spine maturation. Molecular Biology of the Cell. 19: 2026-38. PMID 18287537 DOI: 10.1091/Mbc.E07-08-0802  0.341
2008 Murphy TH, Li P, Betts K, Liu R. Two-photon imaging of stroke onset in vivo reveals that NMDA-receptor independent ischemic depolarization is the major cause of rapid reversible damage to dendrites and spines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1756-72. PMID 18272696 DOI: 10.1523/Jneurosci.5128-07.2008  0.375
2008 Brown CE, Murphy TH. Livin' on the edge: imaging dendritic spine turnover in the peri-infarct zone during ischemic stroke and recovery. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 14: 139-46. PMID 18039977 DOI: 10.1177/1073858407309854  0.532
2007 Liu RR, Brown CE, Murphy TH. Differential regulation of cell proliferation in neurogenic zones in mice lacking cystine transport by xCT. Biochemical and Biophysical Research Communications. 364: 528-33. PMID 17963724 DOI: 10.1016/J.Bbrc.2007.10.036  0.519
2007 Winship IR, Plaa N, Murphy TH. Rapid astrocyte calcium signals correlate with neuronal activity and onset of the hemodynamic response in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6268-72. PMID 17554000 DOI: 10.1523/Jneurosci.4801-06.2007  0.394
2007 Liu Z, Otsu Y, Vasuta C, Nawa H, Murphy TH. Action-potential-independent GABAergic tone mediated by nicotinic stimulation of immature striatal miniature synaptic transmission. Journal of Neurophysiology. 98: 581-93. PMID 17553945 DOI: 10.1152/Jn.00768.2006  0.306
2007 Awatramani GB, Boyd JD, Delaney KR, Murphy TH. Effective release rates at single rat Schaffer collateral-CA1 synapses during sustained theta-burst activity revealed by optical imaging. The Journal of Physiology. 582: 583-95. PMID 17463045 DOI: 10.1113/Jphysiol.2007.130286  0.33
2007 Zhang S, Murphy TH. Imaging the impact of cortical microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivo. Plos Biology. 5: e119. PMID 17456007 DOI: 10.1371/Journal.Pbio.0050119  0.686
2007 Brown CE, Li P, Boyd JD, Delaney KR, Murphy TH. Extensive turnover of dendritic spines and vascular remodeling in cortical tissues recovering from stroke. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4101-9. PMID 17428988 DOI: 10.1523/Jneurosci.4295-06.2007  0.574
2007 Shih AY, Erb H, Murphy TH. Dopamine activates Nrf2-regulated neuroprotective pathways in astrocytes and meningeal cells. Journal of Neurochemistry. 101: 109-19. PMID 17394461 DOI: 10.1111/J.1471-4159.2006.04345.X  0.57
2007 Enright LE, Zhang S, Murphy TH. Fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer V neuron dendritic tufts within single neurons in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 1185-200. PMID 17164811 DOI: 10.1038/Sj.Jcbfm.9600428  0.666
2007 Pacchioni AM, Vallone J, Melendez RI, Shih A, Murphy TH, Kalivas PW. Nrf2 gene deletion fails to alter psychostimulant-induced behavior or neurotoxicity. Brain Research. 1127: 26-35. PMID 17113054 DOI: 10.1016/J.Brainres.2006.10.036  0.549
2006 Shih AY, Erb H, Sun X, Toda S, Kalivas PW, Murphy TH. Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10514-23. PMID 17035536 DOI: 10.1523/Jneurosci.3178-06.2006  0.603
2006 Sun X, Shih AY, Johannssen HC, Erb H, Li P, Murphy TH. Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering in developing neurons and cells at the cerebrospinal fluid and blood-brain interface. The Journal of Biological Chemistry. 281: 17420-31. PMID 16624809 DOI: 10.1074/Jbc.M601567200  0.62
2005 Shih AY, Li P, Murphy TH. A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10321-35. PMID 16267240 DOI: 10.1523/Jneurosci.4014-05.2005  0.615
2005 Zhang S, Boyd J, Delaney K, Murphy TH. Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5333-8. PMID 15930381 DOI: 10.1523/Jneurosci.1085-05.2005  0.647
2005 Shih AY, Imbeault S, Barakauskas V, Erb H, Jiang L, Li P, Murphy TH. Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. The Journal of Biological Chemistry. 280: 22925-36. PMID 15840590 DOI: 10.1074/Jbc.M414635200  0.575
2004 Awatramani G, Murphy TH. Selective reduction of weak synaptic activity awakens dormant synapses. Neuron. 44: 743-4. PMID 15572104 DOI: 10.1016/J.Neuron.2004.11.021  0.332
2004 Otsu Y, Murphy TH. Optical postsynaptic measurement of vesicle release rates for hippocampal synapses undergoing asynchronous release during train stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9076-86. PMID 15483126 DOI: 10.1523/Jneurosci.2060-04.2004  0.301
2004 Li L, Murphy TH, Hayden MR, Raymond LA. Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease. Journal of Neurophysiology. 92: 2738-46. PMID 15240759 DOI: 10.1152/Jn.00308.2004  0.369
2004 Zhang S, Murphy TH. Ca(2+)-independent spine dynamics in cultured hippocampal neurons. Molecular and Cellular Neurosciences. 25: 334-44. PMID 15019949 DOI: 10.1016/J.Mcn.2003.10.017  0.622
2004 Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Molecular Biology of the Cell. 15: 2205-17. PMID 14978216 DOI: 10.1091/Mbc.E03-07-0493  0.314
2003 Li B, Otsu Y, Murphy TH, Raymond LA. Developmental decrease in NMDA receptor desensitization associated with shift to synapse and interaction with postsynaptic density-95. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 11244-54. PMID 14657184 DOI: 10.1523/Jneurosci.23-35-11244.2003  0.348
2003 Li L, Fan M, Icton CD, Chen N, Leavitt BR, Hayden MR, Murphy TH, Raymond LA. Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease. Neurobiology of Aging. 24: 1113-21. PMID 14643383 DOI: 10.1016/J.Neurobiolaging.2003.04.003  0.331
2003 Lee JM, Shih AY, Murphy TH, Johnson JA. NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. The Journal of Biological Chemistry. 278: 37948-56. PMID 12842875 DOI: 10.1074/Jbc.M305204200  0.587
2003 Otsu Y, Murphy TH. Mind-altering miniature neurotransmitter release? Proceedings of the National Academy of Sciences of the United States of America. 100: 5589-90. PMID 12732714 DOI: 10.1073/Pnas.1131911100  0.32
2003 Shih AY, Johnson DA, Wong G, Kraft AD, Jiang L, Erb H, Johnson JA, Murphy TH. Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3394-406. PMID 12716947 DOI: 10.1523/Jneurosci.23-08-03394.2003  0.574
2003 Murphy TH. Activity-dependent synapse development: changing the rules. Nature Neuroscience. 6: 9-11. PMID 12494242 DOI: 10.1038/Nn0103-9  0.35
2002 Li B, Chen N, Luo T, Otsu Y, Murphy TH, Raymond LA. Differential regulation of synaptic and extra-synaptic NMDA receptors. Nature Neuroscience. 5: 833-4. PMID 12195433 DOI: 10.1038/Nn912  0.314
2002 Wang S, Jia Z, Roder J, Murphy TH. AMPA receptor-mediated miniature synaptic calcium transients in GluR2 null mice. Journal of Neurophysiology. 88: 29-40. PMID 12091530 DOI: 10.1152/Jn.2002.88.1.29  0.51
2001 Prange O, Murphy TH. Modular transport of postsynaptic density-95 clusters and association with stable spine precursors during early development of cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9325-33. PMID 11717366 DOI: 10.1523/Jneurosci.21-23-09325.2001  0.669
2001 Laxton AW, Sun MC, Shen H, Murphy TH, Honey CR. The antioxidant enzyme quinone reductase is up-regulated in vivo following cerebral ischemia. Neuroreport. 12: 1045-8. PMID 11303743 DOI: 10.1097/00001756-200104170-00036  0.341
2001 Shih AY, Murphy TH. xCt cystine transporter expression in HEK293 cells: pharmacology and localization. Biochemical and Biophysical Research Communications. 282: 1132-7. PMID 11302733 DOI: 10.1006/Bbrc.2001.4703  0.525
2000 Mackenzie PJ, Kenner GS, Prange O, Murphy TH. Vesicle number does not predict postsynaptic measures of miniature synaptic activity frequency in cultured cortical neurons. Neuroscience. 98: 1-7. PMID 10858606 DOI: 10.1016/S0306-4522(00)00089-0  0.682
1999 Wang S, Prange O, Murphy TH. Amplification of calcium signals at dendritic spines provides a method for CNS quantal analysis. Canadian Journal of Physiology and Pharmacology. 77: 651-9. PMID 10566942 DOI: 10.1139/Y99-073  0.658
1999 Umemiya M, Senda M, Murphy TH. Behaviour of NMDA and AMPA receptor-mediated miniature EPSCs at rat cortical neuron synapses identified by calcium imaging. The Journal of Physiology. 521: 113-22. PMID 10562338 DOI: 10.1111/J.1469-7793.1999.00113.X  0.311
1999 Nakazawa H, Murphy TH. Activation of nuclear calcium dynamics by synaptic stimulation in cultured cortical neurons. Journal of Neurochemistry. 73: 1075-83. PMID 10461897 DOI: 10.1046/J.1471-4159.1999.0731075.X  0.315
1999 Prange O, Murphy TH. Correlation of miniature synaptic activity and evoked release probability in cultures of cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6427-38. PMID 10414971 DOI: 10.1523/Jneurosci.19-15-06427.1999  0.675
1999 Mackenzie PJ, Kenner GS, Prange O, Shayan H, Umemiya M, Murphy TH. Ultrastructural correlates of quantal synaptic function at single CNS synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: RC13. PMID 10366651 DOI: 10.1523/Jneurosci.19-12-J0003.1999  0.681
1999 Prange O, Murphy TH. Analysis of multiquantal transmitter release from single cultured cortical neuron terminals. Journal of Neurophysiology. 81: 1810-7. PMID 10200215 DOI: 10.1152/Jn.1999.81.4.1810  0.645
1999 Shayan H, Murphy TH. Restriction of peroxidase-mediated antibody reactivity to single neurons by local hydrogen peroxide production. Neuroscience. 89: 279-90. PMID 10051235 DOI: 10.1016/S0306-4522(98)00323-6  0.346
1998 Mackenzie PJ, Murphy TH. High safety factor for action potential conduction along axons but not dendrites of cultured hippocampal and cortical neurons. Journal of Neurophysiology. 80: 2089-101. PMID 9772263 DOI: 10.1152/Jn.1998.80.4.2089  0.312
1995 Murphy TH, Baraban JM, Wier WG. Mapping miniature synaptic currents to single synapses using calcium imaging reveals heterogeneity in postsynaptic output. Neuron. 15: 159-68. PMID 7619520 DOI: 10.1016/0896-6273(95)90073-X  0.599
1995 Murphy TH, Baraban JM. Deciphering the role of novel kinase cascades in neuronal signalling Neurobiology of Aging. 16: 257-261. DOI: 10.1016/0197-4580(94)00188-7  0.557
1994 Murphy TH, Blatter LA, Bhat RV, Fiore RS, Wier WG, Baraban JM. Differential regulation of calcium/calmodulin-dependent protein kinase II and p42 MAP kinase activity by synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 1320-31. PMID 8120627 DOI: 10.1523/Jneurosci.14-03-01320.1994  0.613
1994 Ratan RR, Murphy TH, Baraban JM. Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 4385-92. PMID 8027786 DOI: 10.1523/Jneurosci.14-07-04385.1994  0.553
1994 Murphy TH, Baraban JM, Wier WG, Blatter LA. Visualization of quantal synaptic transmission by dendritic calcium imaging. Science (New York, N.Y.). 263: 529-32. PMID 7904774 DOI: 10.1126/Science.7904774  0.624
1994 Ratan RR, Murphy TH, Baraban JM. Oxidative stress induces apoptosis in embryonic cortical neurons. Journal of Neurochemistry. 62: 376-9. PMID 7903353 DOI: 10.1046/J.1471-4159.1994.62010376.X  0.576
1994 Blackstone C, Murphy TH, Moss SJ, Baraban JM, Huganir RL. Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA-preferring glutamate receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 7585-93. PMID 7527845 DOI: 10.1523/Jneurosci.14-12-07585.1994  0.602
1993 Murphy TH, Blatter LA, Wier WG, Baraban JM. Rapid communication between neurons and astrocytes in primary cortical cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 2672-9. PMID 8501531 DOI: 10.1523/Jneurosci.13-06-02672.1993  0.619
1993 Fiore RS, Murphy TH, Sanghera JS, Pelech SL, Baraban JM. Activation of p42 mitogen-activated protein kinase by glutamate receptor stimulation in rat primary cortical cultures. Journal of Neurochemistry. 61: 1626-33. PMID 7693864 DOI: 10.1111/J.1471-4159.1993.Tb09796.X  0.589
1992 Murphy TH, Blatter LA, Wier WG, Baraban JM. Spontaneous synchronous synaptic calcium transients in cultured cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4834-45. PMID 1361198 DOI: 10.1523/Jneurosci.12-12-04834.1992  0.633
1992 Murphy TH, Wright DD, Baraban JM. Phosphoinositide turnover associated with synaptic transmission. Journal of Neurochemistry. 59: 2336-9. PMID 1331330 DOI: 10.1111/J.1471-4159.1992.Tb10130.X  0.6
1991 Murphy TH, Worley PF, Nakabeppu Y, Christy B, Gastel J, Baraban JM. Synaptic regulation of immediate early gene expression in primary cultures of cortical neurons. Journal of Neurochemistry. 57: 1862-72. PMID 1719131 DOI: 10.1111/J.1471-4159.1991.Tb06396.X  0.611
1991 Murphy TH, Worley PF, Baraban JM. L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes. Neuron. 7: 625-35. PMID 1657056 DOI: 10.1016/0896-6273(91)90375-A  0.6
1990 Murphy TH, Schnaar RL, Coyle JT. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 1624-33. PMID 2180770 DOI: 10.1096/Fasebj.4.6.2180770  0.311
1990 Worley PF, Cole AJ, Murphy TH, Christy BA, Nakabeppu Y, Baraban JM. Synaptic regulation of immediate-early genes in brain. Cold Spring Harbor Symposia On Quantitative Biology. 55: 213-23. PMID 2151923 DOI: 10.1101/Sqb.1990.055.01.023  0.566
1990 Murphy TH, Baraban JM. Glutamate toxicity in immature cortical neurons precedes development of glutamate receptor currents. Brain Research. Developmental Brain Research. 57: 146-50. PMID 1982523 DOI: 10.1016/0165-3806(90)90195-5  0.595
1986 ffrench-Mullen JM, Murphy TH, Coyle JT, Fisher RS. Dicarboxylic amino acids block epileptiform activity in hippocampal slice. Epilepsia. 27: 678-84. PMID 2877868 DOI: 10.1111/J.1528-1157.1986.Tb03595.X  0.303
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