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Mark Donowitz, M.D. - Publications

Affiliations: 
Medicine and Physiology Johns Hopkins University, Baltimore, MD 
Area:
IBD, Gastroenterology, Sodium hydrogen exchange
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227 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Johnson K, Yin J, In JG, Kulkarni S, Pasricha P, Tse M, Donowitz M. Cholinergic-induced anion secretion in murine jejunal enteroids involves synergy between muscarinic and nicotinic pathways. American Journal of Physiology. Cell Physiology. PMID 32551856 DOI: 10.1152/Ajpcell.00179.2020  0.308
2020 Foulke-Abel J, Yu H, Sunuwar L, Lin R, Fleckenstein JM, Kaper JB, Donowitz M. Phosphodiesterase 5 (PDE5) restricts intracellular cGMP accumulation during enterotoxigenic infection. Gut Microbes. 1-12. PMID 32378997 DOI: 10.1080/19490976.2020.1752125  0.313
2020 Kasendra M, Luc R, Yin J, Manatakis DV, Kulkarni G, Lucchesi C, Sliz J, Apostolou A, Sunuwar L, Obrigewitch J, Jang KJ, Hamilton GA, Donowitz M, Karalis K. Duodenum Intestine-Chip for preclinical drug assessment in a human relevant model. Elife. 9. PMID 31933478 DOI: 10.7554/Elife.50135  0.305
2020 Sarker R, Yang H, Singh V, Lin R, Tse M, Donowitz M. Sa1089 SLC26A3 (DRA) IS STIMULATED BY BOTH CAMP AND CA2+ SIGNALING AND THE EFFECT IS SYNERGISTIC IN INTESTINAL EPITHELIAL CELLS BY A PROCESS THAT REQUIRES IRBIT. Gastroenterology. 158: S-272. DOI: 10.1016/S0016-5085(20)31364-0  0.334
2019 Sunuwar L, Yin J, Kasendra M, Karalis K, Kaper J, Fleckenstein J, Donowitz M. MECHANICAL STIMULI AFFECT HEAT STABLE ENTEROTOXIN (ST)-CYCLIC GMP SIGNALING IN A HUMAN ENTEROID INTESTINE-CHIP MODEL. Infection and Immunity. PMID 31818966 DOI: 10.1128/Iai.00866-19  0.305
2019 Blutt SE, Klein OD, Donowitz M, Shroyer NF, Guha C, Estes MK. Use of organoids to study regenerative responses to intestinal damage. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 31589468 DOI: 10.1152/Ajpgi.00346.2018  0.315
2019 Chen T, Lin R, Avula L, Sarker R, Yang J, Cha B, Tse CM, McNamara G, Seidler U, Waldman S, Snook A, Bijvelds MJC, de Jonge HR, Li X, Donowitz M. NHERF3 is Necessary for E. coli Heat Stable Enterotoxin (ST)-induced Inhibition of NHE3 - Differences in Signaling in Mouse Small Intestine and Caco-2 Cells. American Journal of Physiology. Cell Physiology. PMID 31365292 DOI: 10.1152/Ajpcell.00351.2018  0.403
2019 Duan T, Cil O, Tse CM, Sarker R, Lin R, Donowitz M, Verkman AS. Inhibition of CFTR-mediated intestinal chloride secretion as potential therapy for bile acid diarrhea. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901166R. PMID 31268738 DOI: 10.1096/Fj.201901166R  0.349
2019 Melia JMP, Lin R, Xavier RJ, Thompson RB, Fu D, Wan F, Sears CL, Donowitz M. Induction of the metal transporter ZIP8 by interferon gamma in intestinal epithelial cells: Potential role of metal dyshomeostasis in Crohn's disease. Biochemical and Biophysical Research Communications. PMID 31151823 DOI: 10.1016/J.Bbrc.2019.05.137  0.329
2019 Tse CM, Yin J, Singh V, Sarker R, Lin R, Verkman AS, Turner JR, Donowitz M. cAMP stimulates SLC26A3 activity in human colon by a CFTR-dependent mechanism that does not require CFTR activity. Cellular and Molecular Gastroenterology and Hepatology. PMID 30659943 DOI: 10.1016/J.Jcmgh.2019.01.002  0.398
2018 Tse CM, In JG, Yin J, Donowitz M, Doucet M, Foulke-Abel J, Ruiz-Perez F, Nataro JP, Zachos NC, Kaper JB, Kovbasnjuk O. Enterohemorrhagic (EHEC)-Secreted Serine Protease EspP Stimulates Electrogenic Ion Transport in Human Colonoid Monolayers. Toxins. 10. PMID 30200426 DOI: 10.3390/Toxins10090351  0.384
2018 King AJ, Siegel M, He Y, Nie B, Wang J, Koo-McCoy S, Minassian NA, Jafri Q, Pan D, Kohler J, Kumaraswamy P, Kozuka K, Lewis JG, Dragoli D, Rosenbaum DP, ... ... Donowitz M, et al. Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. Science Translational Medicine. 10. PMID 30158152 DOI: 10.1126/Scitranslmed.Aam6474  0.373
2018 Yin J, Tse CM, Avula LR, Singh V, Foulke-Abel J, de Jonge HR, Donowitz M. Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers. Cellular and Molecular Gastroenterology and Hepatology. 5: 591-609. PMID 29930980 DOI: 10.1016/J.Jcmgh.2018.02.002  0.345
2018 Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Reports. 22: 1003-1015. PMID 29386123 DOI: 10.1016/J.Celrep.2017.12.093  0.31
2018 Tse M, Singh V, Yin J, Sarker R, Cha B, In J, Doucet M, Kovbasnjuk O, Donowitz M. 788 - Cholera Toxin (CTX)/Forskolin (FSK) Stimulate Dra (SLC26A3) Related HCO 3 Secretion which Involves Apical Trafficking of Dra in Ileal and Proximal Colonic Enteroid Monolayers and CACO-2 Cells Gastroenterology. 154: S-164. DOI: 10.1016/S0016-5085(18)30959-4  0.356
2018 Tse M, In J, Doucet M, Yin J, Foulke-Abel JD, Ruiz-Perez F, Nataro J, Zachos NC, Kaper J, Donowitz M, Kovbasnjuk O. 756 - Enterohemorrhagic E. Coli (EHEC) Secreted Serine Protease Espp, Stimulates Active Electrogenic Ion Transport in Human Colonoid Monolayers Gastroenterology. 154: S-160. DOI: 10.1016/S0016-5085(18)30946-6  0.317
2017 Rajkumar P, Cha B, Yin J, Arend LJ, Păunescu TG, Hirabayashi Y, Donowitz M, Pluznick JL. Identifying the localization and exploring a functional role for Gprc5c in the kidney. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 29196502 DOI: 10.1096/Fj.201700610Rr  0.32
2017 Avula LR, Chen T, Kovbasnjuk O, Donowitz M. Both NHERF3 and NHERF2 are necessary for multiple aspects of acute regulation of NHE3 by elevated Ca(2+), cGMP and lysophosphatidic acid. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00140.2017. PMID 28882822 DOI: 10.1152/Ajpgi.00140.2017  0.429
2017 Blutt SE, Broughman JR, Zou W, Zeng XL, Karandikar UC, In J, Zachos NC, Kovbasnjuk O, Donowitz M, Estes MK. Gastrointestinal microphysiological systems. Experimental Biology and Medicine (Maywood, N.J.). 1535370217710638. PMID 28534432 DOI: 10.1177/1535370217710638  0.304
2017 Yin J, Tse CM, Cha B, Sarker R, Zhu XC, Walentinsson A, Greasley PJ, Donowitz M. A Common NHE3 Single Nucleotide Polymorphism Has Normal Function and Sensitivity to Regulatory Ligands. American Journal of Physiology. Gastrointestinal and Liver Physiology. ajpgi.00044.2017. PMID 28495802 DOI: 10.1152/Ajpgi.00044.2017  0.309
2017 Sarker R, Cha B, Kovbasnjuk O, Cole R, Gabelli S, Tse CM, Donowitz M. Phosphorylation of NHE3-S(719) Regulates NHE3 Activity through the Formation of Multiple Signaling Complexes. Molecular Biology of the Cell. PMID 28495796 DOI: 10.1091/Mbc.E16-12-0862  0.417
2017 Noel G, Baetz NW, Staab JF, Donowitz M, Kovbasnjuk O, Pasetti MF, Zachos NC. A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions. Scientific Reports. 7: 45270. PMID 28345602 DOI: 10.1016/S0016-5085(17)30545-0  0.305
2017 Cha B, Yang J, Singh V, Zachos NC, Sarker RI, Chen TE, Chakraborty M, Tse CM, Donowitz M. PDZ Domain Dependent Regulation of NHE3 Occurs by Both Internal Class II and C-terminal Class I PDZ Binding Motifs. The Journal of Biological Chemistry. PMID 28283572 DOI: 10.1074/Jbc.M116.774489  0.315
2017 Yu H, Hasan NM, In JG, Estes MK, Kovbasnjuk O, Zachos NC, Donowitz M. The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology. Annual Review of Physiology. 79: 291-312. PMID 28192061 DOI: 10.1146/Annurev-Physiol-021115-105211  0.335
2017 Sunuwar L, Asraf H, Donowitz M, Sekler I, Hershfinkel M. The Zn(2+)-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl(-) absorption, via basolateral KCC1, and reduces fluid loss. Biochimica Et Biophysica Acta. PMID 28093242 DOI: 10.1016/J.Bbadis.2017.01.009  0.347
2017 Melia JP, Xavier R, Sears CL, Donowitz M. The Zinc Transporter ZIP8 is Induced by Inflammatory Stimuli on the Apical Membrane of Intestinal Epithelial Cells: Potential Role in Interactions with the Microbiota in Crohn's Disease Gastroenterology. 152: S984. DOI: 10.1016/S0016-5085(17)33333-4  0.363
2017 Singh V, Yang J, Yin J, Tse M, Zachos NC, Berman DE, Petsko G, Donowitz M. Cholera Toxin Destabilizes Retromer to Inhibit NA + /H + Exchanger3 Activity in Intestinal Epithelial Cells- Possible Therapeutic Role of a Retromer Stabilizer in Treating Diarrhea Gastroenterology. 152: S67. DOI: 10.1016/S0016-5085(17)30577-2  0.413
2016 Cil O, Phuan PW, Gillespie AM, Lee S, Tradtrantip L, Yin J, Tse M, Zachos NC, Lin R, Donowitz M, Verkman AS. Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for anti-secretory therapy of diarrheas caused by bacterial enterotoxins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27871064 DOI: 10.1096/Fj.201600891R  0.306
2016 Cil O, Phuan PW, Son JH, Zhu JS, Ku CK, Tabib NA, Teuthorn AP, Ferrera L, Zachos NC, Lin R, Galietta LJ, Donowitz M, Kurth MJ, Verkman AS. Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 27815136 DOI: 10.1016/J.Trsl.2016.10.003  0.328
2016 In JG, Foulke-Abel J, Estes MK, Zachos NC, Kovbasnjuk O, Donowitz M. Human mini-guts: new insights into intestinal physiology and host-pathogen interactions. Nature Reviews. Gastroenterology & Hepatology. PMID 27677718 DOI: 10.1038/Nrgastro.2016.142  0.345
2016 Rehman S, Kekuda R, Tse M, Donowitz M, Rajendran VM. Su1199 Post-Transcriptional Regulation of Na-H Exchanger-3 (NHE3) by Aldosterone Involves microRNA-204 Gastroenterology. 150: S493. DOI: 10.1016/S0016-5085(16)31698-5  0.371
2016 Foulke-Abel J, In J, Tse M, Zachos NC, Donowitz M, Kovbasnjuk O. Sa1413 Enterohemorrhagic E. coli (EHEC)-Secreted Serine Protease EspP is an Enterotoxin and Stimulates Anion Secretion in Human Stem Cell Derived Colonoid Monolayers Gastroenterology. 150: S309. DOI: 10.1016/S0016-5085(16)31082-4  0.303
2016 Baetz NW, Gupta A, Kapoor A, Kovbasnjuk O, Turner J, Donowitz M, Estes M, Zachos NC. 541 Rotavirus Infection in Patients Is Associated With Altered Trafficking of Apical Membrane Transport Proteins Gastroenterology. 150: S113-S114. DOI: 10.1016/S0016-5085(16)30487-5  0.33
2015 Foulke-Abel J, In J, Yin J, Zachos NC, Kovbasnjuk O, Estes MK, de Jonge H, Donowitz M. Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology. Gastroenterology. PMID 26677983 DOI: 10.1053/J.Gastro.2015.11.047  0.352
2015 Zachos NC, Kovbasnjuk O, Foulke-Abel J, In J, Blutt SE, De Jonge HR, Estes MK, Donowitz M. Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and Pathophysiology. The Journal of Biological Chemistry. PMID 26677228 DOI: 10.1074/Jbc.R114.635995  0.318
2015 Saxena K, Blutt SE, Ettayebi K, Zeng XL, Broughman JR, Crawford SE, Karandikar U, Sastri NP, Conner ME, Opekun A, Graham DY, Qureshi W, Sherman V, Foulke-Abel J, In J, ... ... Donowitz M, et al. Human Intestinal Enteroids: A New Model to Study Human Rotavirus Infection, Host Restriction and Pathophysiology. Journal of Virology. PMID 26446608 DOI: 10.1128/Jvi.01930-15  0.317
2015 Janecke AR, Heinz-Erian P, Yin J, Petersen BS, Franke A, Lechner S, Fuchs I, Melancon S, Uhlig HH, Travis S, Marinier E, Perisic V, Ristic N, Gerner P, Booth IW, ... ... Donowitz M, et al. Reduced sodium/proton exchanger NHE3 activity causes congenital sodium diarrhea. Human Molecular Genetics. PMID 26358773 DOI: 10.1093/Hmg/Ddv367  0.336
2015 Yang J, Sarker R, Singh V, Sarker P, Yin J, Chen TE, Chaerkady R, Li X, Tse CM, Donowitz M. The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity. The Biochemical Journal. 470: 77-90. PMID 26251448 DOI: 10.1042/Bj20150238  0.416
2015 Thiagarajah JR, Donowitz M, Verkman AS. Secretory diarrhoea: mechanisms and emerging therapies. Nature Reviews. Gastroenterology & Hepatology. 12: 446-57. PMID 26122478 DOI: 10.1038/Nrgastro.2015.111  0.373
2015 Singh V, Yang J, Cha B, Chen TE, Sarker R, Yin J, Avula LR, Tse M, Donowitz M. Sorting nexin 27 regulates basal and stimulated brush border trafficking of NHE3. Molecular Biology of the Cell. 26: 2030-43. PMID 25851603 DOI: 10.1091/Mbc.E14-12-1597  0.39
2015 Zhu XC, Sarker R, Horton JR, Chakraborty M, Chen TE, Tse CM, Cha B, Donowitz M. Nonsynonymous single nucleotide polymorphisms of NHE3 differentially decrease NHE3 transporter activity. American Journal of Physiology. Cell Physiology. 308: C758-66. PMID 25715704 DOI: 10.1152/Ajpcell.00421.2014  0.361
2015 Chen T, Kocinsky HS, Cha B, Murtazina R, Yang J, Tse CM, Singh V, Cole R, Aronson PS, de Jonge H, Sarker R, Donowitz M. Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site. The Journal of Biological Chemistry. 290: 1952-65. PMID 25480791 DOI: 10.1074/Jbc.M114.590174  0.358
2015 Yang J, Sarker R, Singh V, Sarker P, Yin J, Chen TE, Chaerkady R, Li X, Tse CM, Donowitz M. The NHERF2 sequence adjacent and upstream of the ERM-binding domain affects NHERF2-ezrin binding and dexamethasone stimulated NHE3 activity Biochemical Journal. 470: 77-90. DOI: 10.1042/BJ20150238  0.301
2015 Biswas RS, Wang P, Kovbasnjuk O, Donowitz M, Estes MK, Zachos NC. Tu1401 Differential Intracellular Calcium Inhibition of NHE3 Activity Gastroenterology. 148: S-880. DOI: 10.1016/S0016-5085(15)32988-7  0.387
2015 Foulke-Abel J, In J, Zachos NC, Kovbasnjuk O, Donowitz M. 27 Neutral Na+ Absorption and Fluid/Anion Secretion Are Not Separated Processes in the Human Enteroid Model Gastroenterology. 148: S-9. DOI: 10.1016/S0016-5085(15)30027-5  0.323
2014 Li X, Donowitz M. Fractionation of subcellular membrane vesicles of epithelial and non-epithelial cells by OptiPrepâ„¢ density gradient ultracentrifugation. Methods in Molecular Biology (Clifton, N.J.). 1174: 85-99. PMID 24947376 DOI: 10.1007/978-1-4939-0944-5_6  0.317
2014 Chen T, Hubbard A, Murtazina R, Price J, Yang J, Cha B, Sarker R, Donowitz M. Myosin VI mediates the movement of NHE3 down the microvillus in intestinal epithelial cells. Journal of Cell Science. 127: 3535-45. PMID 24928903 DOI: 10.1242/Jcs.149930  0.393
2014 Yang J, Singh V, Chen TE, Sarker R, Xiong L, Cha B, Jin S, Li X, Tse CM, Zachos NC, Donowitz M. NHERF2/NHERF3 protein heterodimerization and macrocomplex formation are required for the inhibition of NHE3 activity by carbachol. The Journal of Biological Chemistry. 289: 20039-53. PMID 24867958 DOI: 10.1074/Jbc.M114.562413  0.419
2014 Cha B, Chen T, Sarker R, Yang J, Raben D, Tse CM, Kovbasnjuk O, Donowitz M. Lysophosphatidic acid stimulation of NHE3 exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK-PLC-PKCδ signaling. American Journal of Physiology. Cell Physiology. 307: C55-65. PMID 24760985 DOI: 10.1152/Ajpcell.00045.2014  0.431
2014 Foulke-Abel J, In J, Kovbasnjuk O, Zachos NC, Ettayebi K, Blutt SE, Hyser JM, Zeng XL, Crawford SE, Broughman JR, Estes MK, Donowitz M. Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tract. Experimental Biology and Medicine (Maywood, N.J.). 239: 1124-34. PMID 24719375 DOI: 10.1177/1535370214529398  0.33
2014 Singh V, Lin R, Yang J, Cha B, Sarker R, Tse CM, Donowitz M. AKT and GSK-3 are necessary for direct ezrin binding to NHE3 as part of a C-terminal stimulatory complex: role of a novel Ser-rich NHE3 C-terminal motif in NHE3 activity and trafficking. The Journal of Biological Chemistry. 289: 5449-61. PMID 24398676 DOI: 10.1074/Jbc.M113.521336  0.371
2014 Thiagarajah JR, Ko EA, Tradtrantip L, Donowitz M, Verkman AS. Discovery and development of antisecretory drugs for treating diarrheal diseases. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 12: 204-9. PMID 24316107 DOI: 10.1016/J.Cgh.2013.12.001  0.315
2014 Singh V, Yang J, Chen TE, Zachos NC, Kovbasnjuk O, Verkman AS, Donowitz M. Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 12: 27-31. PMID 24184676 DOI: 10.1016/J.Cgh.2013.10.020  0.349
2014 Mroz MS, Keating N, Ward JB, Sarker R, Amu S, Aviello G, Donowitz M, Fallon PG, Keely SJ. Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo. Gut. 63: 808-17. PMID 23916961 DOI: 10.1136/Gutjnl-2013-305088  0.416
2014 Luo M, Liu Y, Riederer B, Patrucco E, Hofmann F, Donowitz M, Tian D, Yun C, de Jonge H, Lamprecht G, Seidler U. Mo1751 CGMP-Dependent Kinase 2, Na+/H+ Regulatory Factor 2, and Na+/H+ Exchanger Isoform 3 Dynamically Assemble Within Lipid Rafts in Murine Small Intestinal Brush Border Membrane Gastroenterology. 146: S-651-S-652. DOI: 10.1016/S0016-5085(14)62368-4  0.406
2014 Yang J, Singh V, Chen T, Sarker R, Cha B, Zachos NC, Donowitz M. Mo1747 NHERF2/NHERF3 Hetero-Dimerization Is Required for Carbachol Inhibition of NHE3 Activity That Involves Formation of NHE3 Macro-Complexes Gastroenterology. 146: S-651. DOI: 10.1016/S0016-5085(14)62364-7  0.368
2014 Foulke-Abel J, In J, Zachos NC, Kovbasnjuk O, Ettayebi K, de Jonge H, Estes MK, Donowitz M. 190 Human Small Intestinal Enteroids Enable Mechanistic Studies of cAMPInduced Changes in Intracellular pH Gastroenterology. 146: S-50. DOI: 10.1016/S0016-5085(14)60173-6  0.315
2014 Singh V, Yang J, Sarker R, Chen T, Cha B, Zachos NC, Donowitz M. 189 Basal and Stimulated BB NHE3 Activity Requires Intracellular SNX27, a PDZDomain Containing Binding Partner of NHE3 That Regulates Endosome to Plasma Membrane Trafficking Gastroenterology. 146: S-50. DOI: 10.1016/S0016-5085(14)60172-4  0.355
2013 Kovbasnjuk O, Zachos NC, In J, Foulke-Abel J, Ettayebi K, Hyser JM, Broughman JR, Zeng XL, Middendorp S, de Jonge HR, Estes MK, Donowitz M. Human enteroids: preclinical models of non-inflammatory diarrhea. Stem Cell Research & Therapy. 4: S3. PMID 24564938 DOI: 10.1186/Scrt364  0.339
2013 Sultan A, Luo M, Yu Q, Riederer B, Xia W, Chen M, Lissner S, Gessner JE, Donowitz M, Yun CC, deJonge H, Lamprecht G, Seidler U. Differential association of the Na+/H+ Exchanger Regulatory Factor (NHERF) family of adaptor proteins with the raft- and the non-raft brush border membrane fractions of NHE3. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 32: 1386-402. PMID 24297041 DOI: 10.1159/000356577  0.388
2013 Zachos NC, Lee LJ, Kovbasnjuk O, Li X, Donowitz M. PLC-γ directly binds activated c-Src, which is necessary for carbachol-mediated inhibition of NHE3 activity in Caco-2/BBe cells. American Journal of Physiology. Cell Physiology. 305: C266-75. PMID 23703528 DOI: 10.1152/Ajpcell.00277.2012  0.358
2013 Yang J, Singh V, Cha B, Chen TE, Sarker R, Murtazina R, Jin S, Zachos NC, Patterson GH, Tse CM, Kovbasnjuk O, Li X, Donowitz M. NHERF2 protein mobility rate is determined by a unique C-terminal domain that is also necessary for its regulation of NHE3 protein in OK cells. The Journal of Biological Chemistry. 288: 16960-74. PMID 23612977 DOI: 10.1074/Jbc.M113.470799  0.381
2013 Lee HW, Cheng J, Kovbasnjuk O, Donowitz M, Guggino WB. Insulin-like growth factor 1 (IGF-1) enhances the protein expression of CFTR. Plos One. 8: e59992. PMID 23555857 DOI: 10.1371/Journal.Pone.0059992  0.314
2013 Donowitz M, Ming Tse C, Fuster D. SLC9/NHE gene family, a plasma membrane and organellar family of Na⁺/H⁺ exchangers. Molecular Aspects of Medicine. 34: 236-51. PMID 23506868 DOI: 10.1016/J.Mam.2012.05.001  0.325
2013 Luo M, Sultan A, Yu Q, Riederer B, Xia W, Luo M, Chen M, Lissner S, Gessner E, Patrucco E, Hofmann F, Donowitz M, Yun CC, de Jonge H, Lamprecht G, et al. cGMP-dependent kinase 2, Na+/H+ regulatory factor 2, and Na+/H+ exchanger isoform 3 assemble within lipid rafts in murine small intestinal brush border membrane Bmc Pharmacology and Toxicology. 14. DOI: 10.1186/2050-6511-14-S1-O31  0.423
2013 Sarker R, Singh V, Yang J, Murtazina R, Chen T, Cha B, Chakraborty M, Kovbasnjuk O, Li X, Zachos NC, Tse M, Donowitz M. Mo1793 CK2 Phosphorylatoin of NHE3 At S719 Is Necessary for the PI3-K/AKT Component of Basal NHE3 Activity and for Carbachol/Ca2+ but Not cAMP Inhibition-Effects Involving the Lipid Raft Pool of NHE3 Gastroenterology. 144: S-665. DOI: 10.1016/S0016-5085(13)62463-4  0.317
2013 Kazi MH, Sarker R, Lin Z, Cha B, Donowitz M, Tse M. 728 Zinc Stimulates Intestinal Na/H Exchanger 3 (NHE3) via Trafficking Effects in a Phospholipase C (PLC) Dependent Manner Gastroenterology. 144: S-130. DOI: 10.1016/S0016-5085(13)60468-0  0.406
2013 Zachos NC, In J, Foulke-Abel J, Middendorp S, de Jonge H, Zeng X, Ettayebi K, Estes MK, Donowitz M, Kovbasnjuk O. 401 Human Ex Vivo Enteroid Culture As a Functional Model of Human Small Intestinal Physiology and Pathophysiology: Inhibition of Na+ Absorption by cAMP and Rotavirus and Stimulation of Cl− Secretion by cAMP Gastroenterology. 144: S-78. DOI: 10.1016/S0016-5085(13)60286-3  0.363
2012 Zizak M, Chen T, Bartonicek D, Sarker R, Zachos NC, Cha B, Kovbasnjuk O, Korac J, Mohan S, Cole R, Chen Y, Tse CM, Donowitz M. Calmodulin kinase II constitutively binds, phosphorylates, and inhibits brush border Na+/H+ exchanger 3 (NHE3) by a NHERF2 protein-dependent process. The Journal of Biological Chemistry. 287: 13442-56. PMID 22371496 DOI: 10.1074/Jbc.M111.307256  0.624
2012 Zachos NC, van Rossum DB, Murtazina R, Chakraborty M, Patterson RL, Donowitz M. 4 A Peptide Mimicking the NHE3 C-Terminus Stimulates Basal and Blocks CA2+ and cAMP Inhibition of NHE3 Activity, and Prevents Cholera Toxin-Induced Mouse Jejunal Fluid Accumulation: Potential Role as Drug Therapy for Diarrhea Gastroenterology. 142: S-1. DOI: 10.1016/S0016-5085(12)60004-3  0.308
2011 Zhu X, Cha B, Zachos NC, Sarker R, Chakraborty M, Chen TE, Kovbasnjuk O, Donowitz M. Elevated calcium acutely regulates dynamic interactions of NHERF2 and NHE3 proteins in opossum kidney (OK) cell microvilli. The Journal of Biological Chemistry. 286: 34486-96. PMID 21799002 DOI: 10.1074/Jbc.M111.230219  0.386
2011 Lin Z, Jin S, Duan X, Wang T, Martini S, Hulamm P, Cha B, Hubbard A, Donowitz M, Guggino SE. Chloride channel (Clc)-5 is necessary for exocytic trafficking of Na+/H+ exchanger 3 (NHE3). The Journal of Biological Chemistry. 286: 22833-45. PMID 21561868 DOI: 10.1074/Jbc.M111.224998  0.366
2011 Murtazina R, Kovbasnjuk O, Chen TE, Zachos NC, Chen Y, Kocinsky HS, Hogema BM, Seidler U, de Jonge HR, Donowitz M. NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileum. American Journal of Physiology. Cell Physiology. 301: C126-36. PMID 21430287 DOI: 10.1152/Ajpcell.00311.2010  0.411
2011 Brett CL, Kallay L, Hua Z, Green R, Chyou A, Zhang Y, Graham TR, Donowitz M, Rao R. Genome-wide analysis reveals the vacuolar pH-stat of Saccharomyces cerevisiae. Plos One. 6: e17619. PMID 21423800 DOI: 10.1371/Journal.Pone.0017619  0.711
2011 Grillon E, Farion R, Fablet K, De Waard M, Tse CM, Donowitz M, Rémy C, Coles JA. The spatial organization of proton and lactate transport in a rat brain tumor. Plos One. 6: e17416. PMID 21390324 DOI: 10.1371/Journal.Pone.0017416  0.32
2011 Sarker R, Valkhoff VE, Zachos NC, Lin R, Cha B, Chen TE, Guggino S, Zizak M, de Jonge H, Hogema B, Donowitz M. NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity. American Journal of Physiology. Cell Physiology. 300: C771-82. PMID 21191106 DOI: 10.1152/Ajpcell.00119.2010  0.462
2011 Lin R, Murtazina R, Cha B, Chakraborty M, Sarker R, Chen TE, Lin Z, Hogema BM, de Jonge HR, Seidler U, Turner JR, Li X, Kovbasnjuk O, Donowitz M. D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process. Gastroenterology. 140: 560-71. PMID 20977906 DOI: 10.1053/J.Gastro.2010.10.042  0.418
2011 Lukyanenko V, Hubbard A, Delannoy M, Donowitz M, Kovbasnjuk O. Towards understanding mechanisms underlying EHEC-induced transcellular transport of nano-objects across an intestinal epithelial barrier Inflammatory Bowel Diseases. 17: S85. DOI: 10.1097/00054725-201112002-00281  0.309
2011 Riederer B, Singh AK, Yeruva S, Sultan A, Rausch B, Engelhardt R, Yun C, Kocher O, Donowitz M, Hogema BM, deJonge H, Seidler U. Glucocorticoid-Mediated Increase in NHE3 Synthesis, Membrane Trafficking and Function is Differentially Impaired in NHERF2 Ko and NHERF3 (PDZK1) Ko Ileum Gastroenterology. 140: S-658. DOI: 10.1016/S0016-5085(11)62727-3  0.306
2011 Cha B, Yang J, Zhang C, Sarker R, Chakraborty M, Zachos NC, Mohan S, Donowitz M. NHE3 Contains Two Cytoskeleton Associated C-Terminal, Ezrin Containing Signaling Complexes, One for Acute Stimulation and One for Inhibition, Which Together Account for Acute NHE3 Regulation Gastroenterology. 140: S-657. DOI: 10.1016/S0016-5085(11)62725-X  0.54
2011 Zachos NC, Lee LJ, Kovbasnjuk O, Li X, Donowitz M. SRC Dynamic Increase in Direct Binding to the PLC-γ SH2 Domain(S), but Not NHE3, is Necessary to Form Signaling Complexes to Allow Carbachol Mediated Inhibition of NHE3 Activity in CACO-2/Bbe Cells Gastroenterology. 140: S-657. DOI: 10.1016/S0016-5085(11)62724-8  0.339
2011 Zizak M, Sarker R, Chen T, Cha B, Gucek M, Cole RN, Tse MC, Donowitz M. CAM Kinase IIγ Inhibits Activity and Directly Binds the C-Terminal Domain of the Intestinal Brush Border Na/H Exchanger NHE3 in a Dymanic, Ca2+ Dependent Manner Gastroenterology. 140: S-133. DOI: 10.1016/S0016-5085(11)60543-X  0.406
2010 Chen M, Sultan A, Cinar A, Yeruva S, Riederer B, Singh AK, Li J, Bonhagen J, Chen G, Yun C, Donowitz M, Hogema B, de Jonge H, Seidler U. Loss of PDZ-adaptor protein NHERF2 affects membrane localization and cGMP- and [Ca2+]- but not cAMP-dependent regulation of Na+/H+ exchanger 3 in murine intestine. The Journal of Physiology. 588: 5049-63. PMID 20962002 DOI: 10.1113/Jphysiol.2010.198721  0.452
2010 Donowitz M, Singh S, Singh P, Salahuddin FF, Chen Y, Chakraborty M, Murtazina R, Gucek M, Cole RN, Zachos NC, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, et al. Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles. Physiological Genomics. 42: 200-10. PMID 20736413 DOI: 10.1152/Physiolgenomics.00001.2010  0.425
2010 Mohan S, Tse CM, Gabelli SB, Sarker R, Cha B, Fahie K, Nadella M, Zachos NC, Tu-Sekine B, Raben D, Amzel LM, Donowitz M. NHE3 activity is dependent on direct phosphoinositide binding at the N terminus of its intracellular cytosolic region. The Journal of Biological Chemistry. 285: 34566-78. PMID 20736165 DOI: 10.1074/Jbc.M110.165712  0.552
2010 Cha B, Zhu XC, Chen W, Jones M, Ryoo S, Zachos NC, Chen TE, Lin R, Sarker R, Kenworthy AK, Tse M, Kovbasnjuk O, Donowitz M. NHE3 mobility in brush borders increases upon NHERF2-dependent stimulation by lyophosphatidic acid. Journal of Cell Science. 123: 2434-43. PMID 20571054 DOI: 10.1242/Jcs.056713  0.393
2010 Hartley JL, Zachos NC, Dawood B, Donowitz M, Forman J, Pollitt RJ, Morgan NV, Tee L, Gissen P, Kahr WH, Knisely AS, Watson S, Chitayat D, Booth IW, Protheroe S, et al. Mutations in TTC37 cause trichohepatoenteric syndrome (phenotypic diarrhea of infancy). Gastroenterology. 138: 2388-98, 2398.e1-2. PMID 20176027 DOI: 10.1053/J.Gastro.2010.02.010  0.32
2010 Lin S, Yeruva S, He P, Singh AK, Zhang H, Chen M, Lamprecht G, de Jonge HR, Tse M, Donowitz M, Hogema BM, Chun J, Seidler U, Yun CC. Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2. Gastroenterology. 138: 649-58. PMID 19800338 DOI: 10.1053/J.Gastro.2009.09.055  0.404
2010 Laiko M, Murtazina R, Malyukova I, Zhu C, Boedeker EC, Gutsal O, O'Malley R, Cole RN, Tarr PI, Murray KF, Kane A, Donowitz M, Kovbasnjuk O. Shiga toxin 1 interaction with enterocytes causes apical protein mistargeting through the depletion of intracellular galectin-3. Experimental Cell Research. 316: 657-66. PMID 19744479 DOI: 10.1016/J.Yexcr.2009.09.002  0.387
2010 Mohan S, Tse MC, Gabelli SB, Sarker R, Cha B, Zachos NC, Raben D, Amzel M, Donowitz M. T1871 NHE3 Activity is Dependent on Direct Phosphatidylinositide Binding at Its Proximal Cytosolic Region Gastroenterology. 138: S-596. DOI: 10.1016/S0016-5085(10)62749-7  0.51
2010 Chen M, Cinar A, Yeruva S, Riederer B, Singh AK, Bonhagen J, Donowitz M, Hogema BM, de Jonge H, Seidler U. T1841 Differential Effect of NHE3 Kinase a Regulatory Protein (E3karp/NHERF2) Knockout on cAMP-, cGMP-, or [Ca2+]-Induced Inhibition of Na+/H+ Exchanger 3 (NHE3) Activity Along the Murine Intestinal Tract Gastroenterology. 138: S-590. DOI: 10.1016/S0016-5085(10)62719-9  0.366
2010 Lin R, Cha B, Chakraborty M, Mohan S, Donowitz M. 1015 A Novel Ser-Rich Motif in the NHE3 C-Terminal Regulatory Domain is Required for Stimulation of Na/H Exchange Activity by AKT as Well as for Direct Ezrin Binding to NHE3 Gastroenterology. 138: S-147. DOI: 10.1016/S0016-5085(10)60674-9  0.597
2010 Zachos NC, Li X, Lee LJ, Donowitz M. 1014 SRC Dynamically Associates With PLC-γ and is Necessary for CA2+-Mediated Inhibition of NHE3 Activity in CACO-2/BBE Cells Gastroenterology. 138: S-147. DOI: 10.1016/S0016-5085(10)60673-7  0.308
2010 Cha B, Zhu XC, Zachos NC, Sarker R, Chakraborty M, Kovbasnjuk O, Donowitz M. The NHERF2 Dependent Dynamic Ca2+/LPA Regulation of NHE3 Mobility and Interaction At the Epithelial Brush Border Biophysical Journal. 98: 56a. DOI: 10.1016/J.Bpj.2009.12.319  0.38
2009 Weinman EJ, Steplock D, Cha B, Kovbasnjuk O, Frost NA, Cunningham R, Shenolikar S, Blanpied TA, Donowitz M. PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. American Journal of Physiology. Renal Physiology. 297: F1560-5. PMID 19794105 DOI: 10.1152/Ajprenal.90657.2008  0.384
2009 Zachos NC, Kovbasnjuk O, Donowitz M. Regulation of intestinal electroneutral sodium absorption and the brush border Na+/H+ exchanger by intracellular calcium. Annals of the New York Academy of Sciences. 1165: 240-8. PMID 19538312 DOI: 10.1111/J.1749-6632.2009.04055.X  0.392
2009 Zachos NC, Li X, Kovbasnjuk O, Hogema B, Sarker R, Lee LJ, Li M, de Jonge H, Donowitz M. NHERF3 (PDZK1) contributes to basal and calcium inhibition of NHE3 activity in Caco-2BBe cells. The Journal of Biological Chemistry. 284: 23708-18. PMID 19535329 DOI: 10.1074/Jbc.M109.012641  0.368
2009 Zachos NC, van Rossum DB, Li X, Caraveo G, Sarker R, Cha B, Mohan S, Desiderio S, Patterson RL, Donowitz M. Phospholipase C-gamma binds directly to the Na+/H+ exchanger 3 and is required for calcium regulation of exchange activity. The Journal of Biological Chemistry. 284: 19437-44. PMID 19473983 DOI: 10.1074/Jbc.M109.006098  0.578
2009 Donowitz M, Mohan S, Zhu CX, Chen TE, Lin R, Cha B, Zachos NC, Murtazina R, Sarker R, Li X. NHE3 regulatory complexes. The Journal of Experimental Biology. 212: 1638-46. PMID 19448074 DOI: 10.1242/Jeb.028605  0.604
2009 Singh AK, Riederer B, Krabbenhöft A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U. Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. The Journal of Clinical Investigation. 119: 540-50. PMID 19221439 DOI: 10.1172/Jci35541  0.345
2009 Malyukova I, Murray KF, Zhu C, Boedeker E, Kane A, Patterson K, Peterson JR, Donowitz M, Kovbasnjuk O. Macropinocytosis in Shiga toxin 1 uptake by human intestinal epithelial cells and transcellular transcytosis. American Journal of Physiology. Gastrointestinal and Liver Physiology. 296: G78-92. PMID 18974311 DOI: 10.1152/Ajpgi.90347.2008  0.362
2009 Sullivan S, Alex P, Dassopoulos T, Zachos NC, Iacobuzio-Donahue C, Donowitz M, Brant SR, Cuffari C, Harris ML, Datta LW, Conklin L, Chen Y, Li X. Downregulation of sodium transporters and NHERF proteins in IBD patients and mouse colitis models: potential contributors to IBD-associated diarrhea. Inflammatory Bowel Diseases. 15: 261-74. PMID 18942765 DOI: 10.1002/Ibd.20743  0.393
2009 Broere N, Chen M, Cinar A, Singh AK, Hillesheim J, Riederer B, Lünnemann M, Rottinghaus I, Krabbenhöft A, Engelhardt R, Rausch B, Weinman EJ, Donowitz M, Hubbard A, Kocher O, et al. Defective jejunal and colonic salt absorption and alteredNa(+)/H (+) exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice. Pflã¼Gers Archiv : European Journal of Physiology. 457: 1079-91. PMID 18758809 DOI: 10.1007/S00424-008-0579-1  0.434
2009 Chen T, Murtazina R, Tse M, Sarker R, Kovbasnjuk O, Zachos NC, Donowitz M, Li X. T1727 Myosin Vi Is Necessary for Setting Brush Border NHE3 Activity: An Effect On NHE3 Trafficking/Endocytosis Gastroenterology. 136: A-567. DOI: 10.1016/S0016-5085(09)62608-1  0.395
2009 Zhu XC, Sarker R, Jingjing T, Chen T, Tse M, Booth IW, Brant SR, Donowitz M, Li X. 886 Do Mutations of NHE3 At the Site of Poorly Functioning NHE3 Polymorphisms Contribute to Diarrhea of Congenital Na Diarrhea? Gastroenterology. 136: A-137. DOI: 10.1016/S0016-5085(09)60615-6  0.416
2009 Malyukova I, Boedeker EC, Donowitz M, Kovbasnjuk O. 551 Shiga Toxin 1 Uptake By Intestinal Epithelial Cells Is CDC-42 Mediated and Clathrin-Independent Gastroenterology. 136: A-86. DOI: 10.1016/S0016-5085(09)60386-3  0.392
2008 Zachos NC, Hodson C, Kovbasnjuk O, Li X, Thelin WR, Cha B, Milgram S, Donowitz M. Elevated intracellular calcium stimulates NHE3 activity by an IKEPP (NHERF4) dependent mechanism. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 22: 693-704. PMID 19088451 DOI: 10.1159/000185553  0.383
2008 Sarker R, Grønborg M, Cha B, Mohan S, Chen Y, Pandey A, Litchfield D, Donowitz M, Li X. Casein kinase 2 binds to the C terminus of Na+/H+ exchanger 3 (NHE3) and stimulates NHE3 basal activity by phosphorylating a separate site in NHE3. Molecular Biology of the Cell. 19: 3859-70. PMID 18614797 DOI: 10.1091/Mbc.E08-01-0019  0.6
2008 Cha B, Donowitz M. The epithelial brush border Na+/H+ exchanger NHE3 associates with the actin cytoskeleton by binding to ezrin directly and via PDZ domain-containing Na+/H+ exchanger regulatory factor (NHERF) proteins. Clinical and Experimental Pharmacology & Physiology. 35: 863-71. PMID 18430067 DOI: 10.1111/J.1440-1681.2008.04931.X  0.409
2008 Maluykova I, Gutsal O, Laiko M, Kane A, Donowitz M, Kovbasnjuk O. Latrunculin B facilitates Shiga toxin 1 transcellular transcytosis across T84 intestinal epithelial cells. Biochimica Et Biophysica Acta. 1782: 370-7. PMID 18342638 DOI: 10.1016/J.Bbadis.2008.01.010  0.36
2008 Malyukova I, Kane A, Donowitz M, Kovbasnjuk O. W1274 Macropinocytosis Is Involved in Shiga Toxin 1 Uptake and Transcytosis By Gb3-Negative Human Intestinal Epithelial Cells Gastroenterology. 134: A-670. DOI: 10.1016/S0016-5085(08)63125-X  0.351
2008 Zhang C, Cha B, Donowitz M. M1723 Basal Activity of the Epithelial Brush Border Na/H Exchanger NHE3 Is Stimulated By Both PI-3K and AKT-Dependent and Independent Pathways Gastroenterology. 134: A-405. DOI: 10.1016/S0016-5085(08)61893-4  0.372
2008 Donowitz M, Singh S, Salahuddin FF, Hogema BM, Gucek M, Cole RN, Chen Y, Murtazina R, Zachos NC, Kovbasnjuk O, Lapierre LA, Broere N, Goldenring JR, deJonge H, Li X. S1770 Proteome of the Small Intestinal Brush Border of the NHERF1 Knock Out Mouse: Up Regulation of Transporters and Pro-Proliferation Molecules Gastroenterology. 134: A-266. DOI: 10.1016/S0016-5085(08)61238-X  0.323
2008 Murtazina R, Kovbasnjuk O, Chen Y, Hogema BM, Seidler UE, Weinman EJ, de Jonge H, Donowitz M. 749 Nherf2 Is Necessary for Basal and All Second Messenger Regulation of NHE3 Activity in Intact Mouse Ileal Na Absorptive Cells Gastroenterology. 134: A-108. DOI: 10.1016/S0016-5085(08)60508-9  0.403
2008 Zachos NC, van Rossum DB, Patterson R, Snyder S, Donowitz M. 744 Phospholipase Cγ (PLCγ) Directly Binds to the Na+/H+ Exchanger 3 (NHE3) C-Terminus Which Is Necessary for Basal and Calcium-Mediated Inhibition of NHE3 Activity Gastroenterology. 134: A-107. DOI: 10.1016/S0016-5085(08)60503-X  0.376
2007 Broere N, Hillesheim J, Tuo B, Jorna H, Houtsmuller AB, Shenolikar S, Weinman EJ, Donowitz M, Seidler U, de Jonge HR, Hogema BM. Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. The Journal of Biological Chemistry. 282: 37575-84. PMID 17947234 DOI: 10.1074/Jbc.M704878200  0.377
2007 Donowitz M, Singh S, Salahuddin FF, Hogema BM, Chen Y, Gucek M, Cole RN, Ham A, Zachos NC, Kovbasnjuk O, Lapierre LA, Broere N, Goldenring J, deJonge H, Li X. Proteome of murine jejunal brush border membrane vesicles. Journal of Proteome Research. 6: 4068-79. PMID 17845021 DOI: 10.1021/Pr0701761  0.387
2007 Donowitz M, Li X. Regulatory binding partners and complexes of NHE3. Physiological Reviews. 87: 825-72. PMID 17615390 DOI: 10.1152/Physrev.00030.2006  0.4
2007 Murtazina R, Kovbasnjuk O, Zachos NC, Li X, Chen Y, Hubbard A, Hogema BM, Steplock D, Seidler U, Hoque KM, Tse CM, De Jonge HR, Weinman EJ, Donowitz M. Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule. The Journal of Biological Chemistry. 282: 25141-51. PMID 17580307 DOI: 10.1074/Jbc.M701910200  0.429
2007 Kovbasnjuk ON, Malyukova I, Gutsal O, Laiko M, Zhu C, Boedeker E, Gucek M, Cole R, Kane A, Donowitz M. Actin turnover is linked to Shiga toxin 1 transcellular transcytosis across intestinal epithelial cells The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A587-A  0.331
2006 Murtazina R, Kovbasnjuk O, Donowitz M, Li X. Na+/H+ exchanger NHE3 activity and trafficking are lipid Raft-dependent. The Journal of Biological Chemistry. 281: 17845-55. PMID 16648141 DOI: 10.1074/Jbc.M601740200  0.435
2006 Cha B, Tse M, Yun C, Kovbasnjuk O, Mohan S, Hubbard A, Arpin M, Donowitz M. The NHE3 juxtamembrane cytoplasmic domain directly binds ezrin: dual role in NHE3 trafficking and mobility in the brush border. Molecular Biology of the Cell. 17: 2661-73. PMID 16540524 DOI: 10.1091/Mbc.E05-09-0843  0.58
2006 Brett CL, Donowitz M, Rao R. Does the proteome encode organellar pH? Febs Letters. 580: 717-9. PMID 16413548 DOI: 10.1016/J.Febslet.2005.12.103  0.697
2006 Cinar A, Chen M, Riederer B, Hogema B, de Jonge H, Donowitz M, Weinman E, Kocher O, Seidler U. Differential effects of PDZ-Adapterprotein NHERF1, E3KARP and PDZK1 knockout on the regulation of NHE3 transport activity in native murine colonic epithelium Zeitschrift FüR Gastroenterologie. 44. DOI: 10.1055/S-2006-950687  0.35
2005 Kovbasnjuk O, Mourtazina R, Baibakov B, Wang T, Elowsky C, Choti MA, Kane A, Donowitz M. The glycosphingolipid globotriaosylceramide in the metastatic transformation of colon cancer. Proceedings of the National Academy of Sciences of the United States of America. 102: 19087-92. PMID 16365318 DOI: 10.1073/Pnas.0506474102  0.305
2005 Wang Y, Cai H, Cebotaru L, Hryciw DH, Weinman EJ, Donowitz M, Guggino SE, Guggino WB. ClC-5: role in endocytosis in the proximal tubule. American Journal of Physiology. Renal Physiology. 289: F850-62. PMID 15942052 DOI: 10.1152/Ajprenal.00011.2005  0.342
2005 Donowitz M, Cha B, Zachos NC, Brett CL, Sharma A, Tse CM, Li X. NHERF family and NHE3 regulation. The Journal of Physiology. 567: 3-11. PMID 15905209 DOI: 10.1113/Jphysiol.2005.090399  0.71
2005 Cha B, Kim JH, Hut H, Hogema BM, Nadarja J, Zizak M, Cavet M, Lee-Kwon W, Lohmann SM, Smolenski A, Tse CM, Yun C, de Jonge HR, Donowitz M. cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein. The Journal of Biological Chemistry. 280: 16642-50. PMID 15722341 DOI: 10.1074/Jbc.M500505200  0.432
2005 Zachos NC, Tse M, Donowitz M. Molecular physiology of intestinal Na+/H+ exchange. Annual Review of Physiology. 67: 411-43. PMID 15709964 DOI: 10.1146/Annurev.Physiol.67.031103.153004  0.432
2005 Brett CL, Donowitz M, Rao R. Evolutionary origins of eukaryotic sodium/proton exchangers. American Journal of Physiology. Cell Physiology. 288: C223-39. PMID 15643048 DOI: 10.1152/Ajpcell.00360.2004  0.74
2004 Choi JW, Lee-Kwon W, Jeon ES, Kang YJ, Kawano K, Kim HS, Suh PG, Donowitz M, Kim JH. Lysophosphatidic acid induces exocytic trafficking of Na(+)/H(+) exchanger 3 by E3KARP-dependent activation of phospholipase C. Biochimica Et Biophysica Acta. 1683: 59-68. PMID 15238220 DOI: 10.1016/J.Bbalip.2004.04.005  0.405
2004 Cha B, Kenworthy A, Murtazina R, Donowitz M. The lateral mobility of NHE3 on the apical membrane of renal epithelial OK cells is limited by the PDZ domain proteins NHERF1/2, but is dependent on an intact actin cytoskeleton as determined by FRAP. Journal of Cell Science. 117: 3353-65. PMID 15226406 DOI: 10.1242/Jcs.01180  0.417
2004 Jung Kang Y, Su Jeon E, Jin Lee H, Oh YS, Suh PG, Sup Jung J, Donowitz M, Ho Kim J. NHERF2 increases platelet-derived growth factor-induced proliferation through PI-3-kinase/Akt-, ERK-, and Src family kinase-dependent pathway. Cellular Signalling. 16: 791-800. PMID 15115658 DOI: 10.1016/J.Cellsig.2003.12.003  0.327
2004 Li X, Zhang H, Cheong A, Leu S, Chen Y, Elowsky CG, Donowitz M. Carbachol regulation of rabbit ileal brush border Na+-H+ exchanger 3 (NHE3) occurs through changes in NHE3 trafficking and complex formation and is Src dependent. The Journal of Physiology. 556: 791-804. PMID 14978207 DOI: 10.1113/Jphysiol.2004.060921  0.433
2004 Li X, Leu S, Cheong A, Zhang H, Baibakov B, Shih C, Birnbaum MJ, Donowitz M. Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation. Gastroenterology. 126: 122-35. PMID 14699494 DOI: 10.1053/J.Gastro.2003.10.061  0.4
2003 Lee-Kwon W, Kim JH, Choi JW, Kawano K, Cha B, Dartt DA, Zoukhri D, Donowitz M. Ca2+-dependent inhibition of NHE3 requires PKC alpha which binds to E3KARP to decrease surface NHE3 containing plasma membrane complexes. American Journal of Physiology. Cell Physiology. 285: C1527-36. PMID 12954600 DOI: 10.1152/Ajpcell.00017.2003  0.371
2003 Lee-Kwon W, Kawano K, Choi JW, Kim JH, Donowitz M. Lysophosphatidic acid stimulates brush border Na+/H+ exchanger 3 (NHE3) activity by increasing its exocytosis by an NHE3 kinase A regulatory protein-dependent mechanism. The Journal of Biological Chemistry. 278: 16494-501. PMID 12595524 DOI: 10.1074/Jbc.M300580200  0.421
2003 Cha B, Oh S, Shanmugaratnam J, Donowitz M, Yun CC. Two histidine residues in the juxta-membrane cytoplasmic domain of Na+/H+ exchanger isoform 3 (NHE3) determine the set point. The Journal of Membrane Biology. 191: 49-58. PMID 12532276 DOI: 10.1007/S00232-002-1044-2  0.396
2003 Jonge H, Hogema B, Hut H, Lohmann S, Smolenski A, Cha B, Donowitz M. Cyclic GMP-dependent protein kinase regulation of epithelial transporters Bmc News and Views. 3. DOI: 10.1186/2048-4623-3-S2-Op005  0.361
2003 Cha B, Edidin M, Kenworthy AK, Donowitz M. The lateral mobility of NHE3 on the apical membrane of polarized epithelial cells is limited by binding to PDZ domain proteins NHERF1/2 as determined by fluorescence recovery after photobleaching (FRAP) Gastroenterology. 124: A472. DOI: 10.1016/S0016-5085(03)82387-9  0.331
2003 Zizak M, Bartonicek D, Cha B, Murtazina R, Kim J, Lee-Kwon W, Gorelick F, Tse M, Donowitz M. Calcium/calmodulin dependent protein kinase II constitutively binds and regulates the ileal BB Na+/H+ exchanger NHE3 Gastroenterology. 124: A471. DOI: 10.1016/S0016-5085(03)82384-3  0.377
2003 Li X, Cheong A, Leu S, Zhang H, Donowitz M. Carbachol-mediated inhibition of Na/H exchanger 3 (NHE3) in ileal brush border (BB) occurs through regulated trafficking and complex formation and involves multiple pools of NHE3 Gastroenterology. 124: A308-A309. DOI: 10.1016/S0016-5085(03)81554-8  0.403
2003 Lee-Kwon W, Kawano K, Choi JW, Kim J, Donowitz M. Lysophosphatidic acid stimulates the brush border Na/H exchanger NHE3 in Na absorptive epithelial cells by increasing exocytic trafficking by a PI 3-kinase dependent mechanism that requires E3KARP Gastroenterology. 124: A40. DOI: 10.1016/S0016-5085(03)80196-8  0.431
2002 Akhter S, Kovbasnjuk O, Li X, Cavet M, Noel J, Arpin M, Hubbard AL, Donowitz M. Na(+)/H(+) exchanger 3 is in large complexes in the center of the apical surface of proximal tubule-derived OK cells. American Journal of Physiology. Cell Physiology. 283: C927-40. PMID 12176749 DOI: 10.1152/Ajpcell.00613.2001  0.589
2002 Mahon MJ, Donowitz M, Yun CC, Segre GV. Na(+)/H(+ ) exchanger regulatory factor 2 directs parathyroid hormone 1 receptor signalling. Nature. 417: 858-61. PMID 12075354 DOI: 10.1038/Nature00816  0.382
2002 Kim JH, Lee-Kwon W, Park JB, Ryu SH, Yun CH, Donowitz M. Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis. The Journal of Biological Chemistry. 277: 23714-24. PMID 11948184 DOI: 10.1074/Jbc.M200835200  0.336
2002 Brett CL, Wei Y, Donowitz M, Rao R. Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. American Journal of Physiology. Cell Physiology. 282: C1031-41. PMID 11940519 DOI: 10.1152/Ajpcell.00420.2001  0.759
2002 Edwards SL, Donald JA, Toop T, Donowitz M, Tse CM. Immunolocalisation of sodium/proton exchanger-like proteins in the gills of elasmobranchs. Comparative Biochemistry and Physiology. Part a, Molecular & Integrative Physiology. 131: 257-65. PMID 11818215 DOI: 10.1016/S1095-6433(01)00449-4  0.414
2001 Li X, Galli T, Leu S, Wade JB, Weinman EJ, Leung G, Cheong A, Louvard D, Donowitz M. Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3. The Journal of Physiology. 537: 537-52. PMID 11731584 DOI: 10.1111/J.1469-7793.2001.00537.X  0.365
2001 Cavet ME, Akhter S, Murtazina R, Sanchez de Medina F, Tse CM, Donowitz M. Half-lives of plasma membrane Na(+)/H(+) exchangers NHE1-3: plasma membrane NHE2 has a rapid rate of degradation. American Journal of Physiology. Cell Physiology. 281: C2039-48. PMID 11698263 DOI: 10.1152/Ajpcell.2001.281.6.C2039  0.635
2001 Lee-Kwon W, Johns DC, Cha B, Cavet M, Park J, Tsichlis P, Donowitz M. Constitutively active phosphatidylinositol 3-kinase and AKT are sufficient to stimulate the epithelial Na+/H+ exchanger 3. The Journal of Biological Chemistry. 276: 31296-304. PMID 11375999 DOI: 10.1074/Jbc.M103900200  0.36
2001 Wade JB, Welling PA, Donowitz M, Shenolikar S, Weinman EJ. Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. American Journal of Physiology. Cell Physiology. 280: C192-8. PMID 11121391 DOI: 10.1152/Ajpcell.2001.280.1.C192  0.41
2001 Cha B, Kim J, Hut H, Kwon WL, Nadarajah J, Tse M, Cavet M, Yun C, DeJonge H, Donowitz M. E3KARP (NHE3 kinase a anchoring protein) is necessary for cGMP regulation of NHE3: Demonstration of a plasma membrane signaling complex containing NHE3, E3KARP, and cGMP kinase II Gastroenterology. 120: A85. DOI: 10.1016/S0016-5085(08)80420-9  0.329
2000 Donowitz M, Janecki A, Akhter S, Cavet ME, Sanchez F, Lamprecht G, Zizak M, Kwon WL, Khurana S, Yun CH, Tse CM. Short-term regulation of NHE3 by EGF and protein kinase C but not protein kinase A involves vesicle trafficking in epithelial cells and fibroblasts. Annals of the New York Academy of Sciences. 915: 30-42. PMID 11193592 DOI: 10.1111/J.1749-6632.2000.Tb05221.X  0.641
2000 Kanai F, Marignani PA, Sarbassova D, Yagi R, Hall RA, Donowitz M, Hisaminato A, Fujiwara T, Ito Y, Cantley LC, Yaffe MB. TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins. The Embo Journal. 19: 6778-91. PMID 11118213 DOI: 10.1093/Emboj/19.24.6778  0.35
2000 Turner JR, Black ED, Ward J, Tse CM, Uchwat FA, Alli HA, Donowitz M, Madara JL, Angle JM. Transepithelial resistance can be regulated by the intestinal brush-border Na(+)/H(+) exchanger NHE3. American Journal of Physiology. Cell Physiology. 279: C1918-24. PMID 11078707 DOI: 10.1152/Ajpcell.2000.279.6.C1918  0.413
2000 Janecki AJ, Janecki M, Akhter S, Donowitz M. Quantitation of plasma membrane expression of a fusion protein of Na/H exchanger NHE3 and green fluorescence protein (GFP) in living PS120 fibroblasts. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 48: 1479-92. PMID 11036091 DOI: 10.1177/002215540004801105  0.586
2000 Zizak M, Cavet ME, Bayle D, Tse CM, Hallen S, Sachs G, Donowitz M. Na(+)/H(+) exchanger NHE3 has 11 membrane spanning domains and a cleaved signal peptide: topology analysis using in vitro transcription/translation. Biochemistry. 39: 8102-12. PMID 10891093 DOI: 10.1021/Bi000870T  0.359
2000 Weinman EJ, Steplock D, Donowitz M, Shenolikar S. NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. Biochemistry. 39: 6123-9. PMID 10821685 DOI: 10.1021/Bi000064M  0.462
2000 Janecki AJ, Janecki M, Akhter S, Donowitz M. Basic fibroblast growth factor stimulates surface expression and activity of Na(+)/H(+) exchanger NHE3 via mechanism involving phosphatidylinositol 3-kinase. The Journal of Biological Chemistry. 275: 8133-42. PMID 10713136 DOI: 10.1074/Jbc.275.11.8133  0.601
2000 Akhter S, Cavet ME, Tse CM, Donowitz M. C-terminal domains of Na(+)/H(+) exchanger isoform 3 are involved in the basal and serum-stimulated membrane trafficking of the exchanger. Biochemistry. 39: 1990-2000. PMID 10684649 DOI: 10.1021/Bi991739S  0.606
2000 Donowitz M, Tse M. Chapter 12 Molecular physiology of mammalian epithelial Na+/H+ exchangers NHE2 and NHE3 Current Topics in Membranes. 50: 437-451,IN2,452-498. DOI: 10.1016/S1063-5823(00)50014-3  0.435
2000 Hogan D, Repishti M, Pratha V, Donowitz M, Tse M, Isenberg J. Human duodenal bicarbonate absorption involves both brush border NA+/H+ exchangers NHE2 and NHE3 Gastroenterology. 118: A606. DOI: 10.1016/S0016-5085(00)84562-X  0.394
2000 Li X, Galli T, Louvard D, Donowitz M. NA+/H+-exchanger 3 (NHE3) is present in lipid rafts in the ileal absorptive cell brush border: A role for rafts and the actin cytoskeleton in endocytosis of NHE3 Gastroenterology. 118: A599. DOI: 10.1016/S0016-5085(00)84536-9  0.385
2000 Cavet ME, Akhter S, Tse C, Donowitz M. Differences in plasma membrane half-life and membrane trafficking of the epithelial Na+/H+exchangers NHE2 and NHE3: Insights into functions of these proteins Gastroenterology. 118: A597. DOI: 10.1016/S0016-5085(00)84527-8  0.594
2000 Akhter S, Kovbasnjuk O, Hubbard A, Donowitz M. Separate functions for brush border membrane and endosomal NHE3 in a polarized epithelial cell line Gastroenterology. 118: A596. DOI: 10.1016/S0016-5085(00)84523-0  0.524
2000 Janecki AJ, Donowitz M, Janecki M. Expression and regulation of a fusion protein of naih exchanger NHE3 and green fluorescent protein in epithelial Caco-2 cells Gastroenterology. 118: A84. DOI: 10.1016/S0016-5085(00)82413-0  0.322
1999 Janecki AJ, Montrose MH, Tse CM, de Medina FS, Zweibaum A, Donowitz M. Development of an endogenous epithelial Na/Hexchanger (NHE3) in three clones of Caco-2 cells. American Journal of Physiology. Gastrointestinal and Liver Physiology. 277: G292-G305. PMID 29591707 DOI: 10.1152/ajpgi.1999.277.2.G292  0.347
1999 Cavet ME, Akhter S, de Medina FS, Donowitz M, Tse CM. Na/Hexchangers (NHE1-3) have similar turnover numbers but different percentages on the cell surface. American Journal of Physiology. Cell Physiology. 277: C1111-C1121. PMID 29591090 DOI: 10.1152/ajpcell.1999.277.6.C1111  0.483
1999 Akhter S, Nath SK, Tse CM, Williams J, Zasloff M, Donowitz M. Squalamine, a novel cationic steroid, specifically inhibits the brush-border Na/Hexchanger isoform NHE3. American Journal of Physiology. Cell Physiology. 276: C136-C144. PMID 29590794 DOI: 10.1152/ajpcell.1999.276.1.C136  0.598
1999 Cavet ME, Akhter S, de Medina FS, Donowitz M, Tse CM. Na(+)/H(+) exchangers (NHE1-3) have similar turnover numbers but different percentages on the cell surface. The American Journal of Physiology. 277: C1111-21. PMID 10600762 DOI: 10.1152/Ajpcell.1999.277.6.C1111  0.613
1999 Zizak M, Lamprecht G, Steplock D, Tariq N, Shenolikar S, Donowitz M, Yun CH, Weinman EJ. cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor. The Journal of Biological Chemistry. 274: 24753-8. PMID 10455146 DOI: 10.1074/Jbc.274.35.24753  0.398
1999 Janecki AJ, Montrose MH, Tse CM, de Medina FS, Zweibaum A, Donowitz M. Development of an endogenous epithelial Na(+)/H(+) exchanger (NHE3) in three clones of caco-2 cells. The American Journal of Physiology. 277: G292-305. PMID 10444443 DOI: 10.1152/Ajpgi.1999.277.2.G292  0.464
1999 Nath SK, Kambadur R, Yun CH, Donowitz M, Tse CM. NHE2 contains subdomains in the COOH terminus for growth factor and protein kinase regulation. The American Journal of Physiology. 276: C873-82. PMID 10199818 DOI: 10.1152/Ajpcell.1999.276.4.C873  0.362
1999 Akhter S, Nath SK, Tse CM, Williams J, Zasloff M, Donowitz M. Squalamine, a novel cationic steroid, specifically inhibits the brush-border Na+/H+ exchanger isoform NHE3. The American Journal of Physiology. 276: C136-44. PMID 9886929 DOI: 10.1152/Ajpcell.1999.276.1.C136  0.637
1998 Wormmeester L, De Medina FS, Kokke F, Tse CM, Khurana S, Bowser J, Cohen ME, Donowitz M. Quantitative contribution of NHE2 and NHE3 to rabbit ileal brush-border Na/Hexchange. American Journal of Physiology. Cell Physiology. 274: C1261-C1272. PMID 29591067 DOI: 10.1152/ajpcell.1998.274.5.C1261  0.307
1998 Lee MG, Schultheis PJ, Yan M, Shull GE, Bookstein C, Chang E, Tse M, Donowitz M, Park K, Muallem S. Membrane-limited expression and regulation of Na+-H+ exchanger isoforms by P2 receptors in the rat submandibular gland duct. The Journal of Physiology. 513: 341-57. PMID 9806987 DOI: 10.1111/J.1469-7793.1998.341Bb.X  0.405
1998 Donowitz M, Khurana S, Tse CM, Yun CH. G protein-coupled receptors in gastrointestinal physiology. III. Asymmetry in plasma membrane signal transduction: lessons from brush-border Na+/H+ exchangers. The American Journal of Physiology. 274: G971-7. PMID 9696719 DOI: 10.1152/Ajpgi.1998.274.6.G971  0.379
1998 Wormmeester L, Sanchez de Medina F, Kokke F, Tse CM, Khurana S, Bowser J, Cohen ME, Donowitz M. Quantitative contribution of NHE2 and NHE3 to rabbit ileal brush-border Na+/H+ exchange. The American Journal of Physiology. 274: C1261-72. PMID 9612213 DOI: 10.1152/Ajpcell.1998.274.5.C1261  0.431
1998 Donowitz M, De La Horra C, Calonge ML, Wood IS, Dyer J, Gribble SM, De Medina FS, Tse CM, Shirazi-Beechey SP, Ilundain AA. In birds, NHE2 is major brush-border Na+/H+ exchanger in colon and is increased by a low-NaCl diet. The American Journal of Physiology. 274: R1659-69. PMID 9608021 DOI: 10.1152/Ajpregu.1998.274.6.R1659  0.411
1998 Janecki AJ, Montrose MH, Zimniak P, Zweibaum A, Tse CM, Khurana S, Donowitz M. Subcellular redistribution is involved in acute regulation of the brush border Na+/H+ exchanger isoform 3 in human colon adenocarcinoma cell line Caco-2. Protein kinase C-mediated inhibition of the exchanger. The Journal of Biological Chemistry. 273: 8790-8. PMID 9535857 DOI: 10.1074/Jbc.273.15.8790  0.469
1998 He X, Kuijpers GA, Goping G, Kulakusky JA, Zheng C, Delporte C, Tse CM, Redman RS, Donowitz M, Pollard HB, Baum BJ. A polarized salivary cell monolayer useful for studying transepithelial fluid movement in vitro. Pflã¼Gers Archiv : European Journal of Physiology. 435: 375-81. PMID 9426293 DOI: 10.1007/S004240050526  0.374
1998 Yun C, Lamprecht G, Weinman E, Donowitz M. Na+/H+ exchanger NHE3 interacts with PDZ domains of the regulatory proteins, E3KARP and NHERF Gastroenterology. 114: A436. DOI: 10.1016/S0016-5085(98)81764-2  0.371
1998 Cavet M, Tse C, Akhter S, Yun C, Donowitz M. Structure-function studies of membrane domain-cytoplasmic domain and membrane domain-membrane doman chimeras of Na+/H+ exchanger isoforms NHE1 and NHE3 Gastroenterology. 114: A357. DOI: 10.1016/S0016-5085(98)81447-9  0.57
1998 Akhter S, Cavet M, Tse C, Donowitz M. Regulatory mechanisms of cloned Na+/H+ exchangers involve change in the amount of plasma membrane exchanger: Use of cell surface biotinylation Gastroenterology. 114: A347. DOI: 10.1016/S0016-5085(98)81405-4  0.602
1997 Khurana S, Arpin M, Patterson R, Donowitz M. Ileal microvillar protein villin is tyrosine-phosphorylated and associates with PLC-gamma1. Role of cytoskeletal rearrangement in the carbachol-induced inhibition of ileal NaCl absorption. The Journal of Biological Chemistry. 272: 30115-21. PMID 9374490 DOI: 10.1074/Jbc.272.48.30115  0.395
1997 Sun AM, Liu Y, Dworkin LD, Tse CM, Donowitz M, Yip KP. Na+/H+ exchanger isoform 2 (NHE2) is expressed in the apical membrane of the medullary thick ascending limb. The Journal of Membrane Biology. 160: 85-90. PMID 9351894 DOI: 10.1007/S002329900297  0.354
1997 Yip JW, Ko WH, Viberti G, Huganir RL, Donowitz M, Tse CM. Regulation of the epithelial brush border Na+/H+ exchanger isoform 3 stably expressed in fibroblasts by fibroblast growth factor and phorbol esters is not through changes in phosphorylation of the exchanger. The Journal of Biological Chemistry. 272: 18473-80. PMID 9218492 DOI: 10.1074/Jbc.272.29.18473  0.378
1997 Yun CH, Oh S, Zizak M, Steplock D, Tsao S, Tse CM, Weinman EJ, Donowitz M. cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein. Proceedings of the National Academy of Sciences of the United States of America. 94: 3010-5. PMID 9096337 DOI: 10.1073/Pnas.94.7.3010  0.463
1997 Helmle-Kolb C, Di Sole F, Forgo J, Hilfiker H, Tse CM, Casavola V, Donowitz M, Murer H. Regulation of the transfected Na+/H+-exchanger NHE3 in MDCK cells by vasotocin. Pflã¼Gers Archiv : European Journal of Physiology. 434: 123-31. PMID 9094265 DOI: 10.1007/S004240050372  0.465
1997 He X, Tse CM, Donowitz M, Alper SL, Gabriel SE, Baum BJ. Polarized distribution of key membrane transport proteins in the rat submandibular gland. Pflã¼Gers Archiv : European Journal of Physiology. 433: 260-8. PMID 9064641 DOI: 10.1007/S004240050276  0.41
1997 Maher MM, Gontarek JD, Bess RS, Donowitz M, Yeo CJ. The Na+/H+ exchange isoform NHE3 regulates basal canine ileal Na+ absorption in vivo. Gastroenterology. 112: 174-83. PMID 8978356 DOI: 10.1016/S0016-5085(97)70232-4  0.349
1997 Janecki A, Khurana S, Montrose M, Zimniak P, Donowitz M. Protein kinase C (PKC) is involved in translocation of endogenous apical NA/H exchanger (NHE3) in human colonic adenocarcinoma cells CACO-2 Faseb Journal. 11: A513.  0.321
1996 Burnett AL, Donowitz M, Marshall FF. Inhibition of transport processes of intestinal segments following augmentation enterocystoplasty in rats. The Journal of Urology. 156: 1872-5. PMID 8863635 DOI: 10.1016/S0022-5347(01)65556-3  0.321
1996 Hoogerwerf WA, Tsao SC, Devuyst O, Levine SA, Yun CH, Yip JW, Cohen ME, Wilson PD, Lazenby AJ, Tse CM, Donowitz M. NHE2 and NHE3 are human and rabbit intestinal brush-border proteins. The American Journal of Physiology. 270: G29-41. PMID 8772498 DOI: 10.1152/Ajpgi.1996.270.1.G29  0.423
1996 Maher MM, Gontarek JD, Jimenez RE, Donowitz M, Yeo CJ. Role of brush border Na+/H+ exchange in canine ileal absorption. Digestive Diseases and Sciences. 41: 651-9. PMID 8674384 DOI: 10.1007/Bf02213119  0.389
1996 Nath SK, Hang CY, Levine SA, Yun CH, Montrose MH, Donowitz M, Tse CM. Hyperosmolarity inhibits the Na+/H+ exchanger isoforms NHE2 and NHE3: an effect opposite to that on NHE1. The American Journal of Physiology. 270: G431-41. PMID 8638709 DOI: 10.1152/Ajpgi.1996.270.3.G431  0.422
1996 Khurana S, Nath SK, Levine SA, Bowser JM, Tse CM, Cohen ME, Donowitz M. Brush border phosphatidylinositol 3-kinase mediates epidermal growth factor stimulation of intestinal NaCl absorption and Na+/H+ exchange. The Journal of Biological Chemistry. 271: 9919-27. PMID 8626628 DOI: 10.1074/Jbc.271.17.9919  0.436
1996 Khurana S, Kreydiyyeh S, Aronzon A, Hoogerwerf WA, Rhee SG, Donowitz M, Cohen ME. Asymmetric signal transduction in polarized ileal Na(+)-absorbing cells: carbachol activates brush-border but not basolateral-membrane PIP2-PLC and translocates PLC-gamma 1 only to the brush border. The Biochemical Journal. 313: 509-18. PMID 8573085 DOI: 10.1042/Bj3130509  0.42
1995 Sears CL, Firoozmand F, Mellander A, Chambers FG, Eromar IG, Bot AG, Scholte B, De Jonge HR, Donowitz M. Genistein and tyrphostin 47 stimulate CFTR-mediated Cl- secretion in T84 cell monolayers. The American Journal of Physiology. 269: G874-82. PMID 8572219 DOI: 10.1152/Ajpgi.1995.269.6.G874  0.393
1995 Levine SA, Nath SK, Yun CH, Yip JW, Montrose M, Donowitz M, Tse CM. Separate C-terminal domains of the epithelial specific brush border Na+/H+ exchanger isoform NHE3 are involved in stimulation and inhibition by protein kinases/growth factors. The Journal of Biological Chemistry. 270: 13716-25. PMID 7775426 DOI: 10.1074/Jbc.270.23.13716  0.41
1995 Yun CH, Tse CM, Nath S, Levine SL, Donowitz M. Structure/function studies of mammalian Na-H exchangers--an update. The Journal of Physiology. 482: 1S-6S. PMID 7730970 DOI: 10.1113/Jphysiol.1995.Sp020558  0.376
1995 Yun CH, Tse CM, Nath SK, Levine SA, Brant SR, Donowitz M. Mammalian Na+/H+ exchanger gene family: structure and function studies. The American Journal of Physiology. 269: G1-11. PMID 7631785 DOI: 10.1152/Ajpgi.1995.269.1.G1  0.428
1995 Brant SR, Yun CH, Donowitz M, Tse CM. Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3. The American Journal of Physiology. 269: C198-206. PMID 7631746 DOI: 10.1152/Ajpcell.1995.269.1.C198  0.358
1995 Yun CH, Tse CM, Donowitz M. Chimeric Na+/H+ exchangers: an epithelial membrane-bound N-terminal domain requires an epithelial cytoplasmic C-terminal domain for regulation by protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 92: 10723-7. PMID 7479872 DOI: 10.1073/Pnas.92.23.10723  0.435
1994 Donowitz M, Montgomery JL, Walker MS, Cohen ME. Brush-border tyrosine phosphorylation stimulates ileal neutral NaCl absorption and brush-border Na(+)-H+ exchange. The American Journal of Physiology. 266: G647-56. PMID 8179002 DOI: 10.1152/Ajpgi.1994.266.4.G647  0.423
1994 Homaidan FR, Tang SH, Donowitz M, Sharp GW. Effects of galanin on short circuit current and electrolyte transport in rabbit ileum. Peptides. 15: 1431-6. PMID 7535426 DOI: 10.1016/0196-9781(94)90120-1  0.404
1994 Tse CM, Levine SA, Yun CH, Khurana S, Donowitz M. Na+/H+ exchanger-2 is an O-linked but not an N-linked sialoglycoprotein. Biochemistry. 33: 12954-61. PMID 7524659 DOI: 10.1021/Bi00248A003  0.372
1994 Tse CM, Levine SA, Yun CHC, Brant SR, Natha S, Pouysségur J, Donowitz M. Molecular properties, kinetics and regulation of mammalian Na+/H+ exchangers Cellular Physiology and Biochemistry. 4: 282-300. DOI: 10.1159/000154731  0.44
1993 Yun CH, Little PJ, Nath SK, Levine SA, Pouyssegur J, Tse CM, Donowitz M. Leu143 in the putative fourth membrane spanning domain is critical for amiloride inhibition of an epithelial Na+/H+ exchanger isoform (NHE-2). Biochemical and Biophysical Research Communications. 193: 532-9. PMID 8512555 DOI: 10.1006/Bbrc.1993.1656  0.412
1993 Tse CM, Levine SA, Yun CH, Brant SR, Pouyssegur J, Montrose MH, Donowitz M. Functional characteristics of a cloned epithelial Na+/H+ exchanger (NHE3): resistance to amiloride and inhibition by protein kinase C. Proceedings of the National Academy of Sciences of the United States of America. 90: 9110-4. PMID 8415663 DOI: 10.1073/Pnas.90.19.9110  0.449
1993 Tse M, Levine S, Yun C, Brant S, Counillon LT, Pouyssegur J, Donowitz M. Structure/function studies of the epithelial isoforms of the mammalian Na+/H+ exchanger gene family. The Journal of Membrane Biology. 135: 93-108. PMID 8411138 DOI: 10.1007/Bf00231435  0.348
1993 Yun CH, Gurubhagavatula S, Levine SA, Montgomery JL, Brant SR, Cohen ME, Cragoe EJ, Pouyssegur J, Tse CM, Donowitz M. Glucocorticoid stimulation of ileal Na+ absorptive cell brush border Na+/H+ exchange and association with an increase in message for NHE-3, an epithelial Na+/H+ exchanger isoform. The Journal of Biological Chemistry. 268: 206-11. PMID 8380155  0.307
1993 Mrkic B, Tse CM, Forgo J, Helmle-Kolb C, Donowitz M, Murer H. Identification of PTH-responsive Na/H-exchanger isoforms in a rabbit proximal tubule cell line (RKPC-2). Pflã¼Gers Archiv : European Journal of Physiology. 424: 377-84. PMID 8255719 DOI: 10.1007/Bf00374897  0.466
1993 Levine SA, Montrose MH, Tse CM, Donowitz M. Kinetics and regulation of three cloned mammalian Na+/H+ exchangers stably expressed in a fibroblast cell line. The Journal of Biological Chemistry. 268: 25527-35. PMID 8244988  0.337
1993 Brant SR, Bernstein M, Wasmuth JJ, Taylor EW, McPherson JD, Li X, Walker S, Pouyssegur J, Donowitz M, Tse CM. Physical and genetic mapping of a human apical epithelial Na+/H+ exchanger (NHE3) isoform to chromosome 5p15.3. Genomics. 15: 668-72. PMID 8096830 DOI: 10.1006/Geno.1993.1122  0.329
1993 Tse CM, Levine SA, Yun CH, Montrose MH, Little PJ, Pouyssegur J, Donowitz M. Cloning and expression of a rabbit cDNA encoding a serum-activated ethylisopropylamiloride-resistant epithelial Na+/H+ exchanger isoform (NHE-2). The Journal of Biological Chemistry. 268: 11917-24. PMID 7685025  0.327
1992 Zeitlin PL, Crawford I, Lu L, Woel S, Cohen ME, Donowitz M, Montrose MH, Hamosh A, Cutting GR, Gruenert D. CFTR protein expression in primary and cultured epithelia. Proceedings of the National Academy of Sciences of the United States of America. 89: 344-7. PMID 1370353 DOI: 10.1073/Pnas.89.1.344  0.336
1991 Cohen ME, Wesolek J, McCullen J, Rys-Sikora K, Pandol S, Rood RP, Sharp GW, Donowitz M. Carbachol- and elevated Ca(2+)-induced translocation of functionally active protein kinase C to the brush border of rabbit ileal Na+ absorbing cells. The Journal of Clinical Investigation. 88: 855-63. PMID 1885773 DOI: 10.1172/Jci115387  0.406
1991 Tse CM, Ma AI, Yang VW, Watson AJ, Levine S, Montrose MH, Potter J, Sardet C, Pouyssegur J, Donowitz M. Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger. The Embo Journal. 10: 1957-67. PMID 1712287 DOI: 10.1002/J.1460-2075.1991.Tb07725.X  0.428
1991 Levine SA, Donowitz M, Watson AJ, Sharp GW, Crane JK, Weikel CS. Characterization of the synergistic interaction of Escherichia coli heat-stable toxin and carbachol. The American Journal of Physiology. 261: G592-601. PMID 1656772 DOI: 10.1152/Ajpgi.1991.261.4.G592  0.314
1991 Watson AJ, Levine S, Donowitz M, Montrose MH. Kinetics and regulation of a polarized Na(+)-H+ exchanger from Caco-2 cells, a human intestinal cell line. The American Journal of Physiology. 261: G229-38. PMID 1651659 DOI: 10.1152/Ajpgi.1991.261.2.G229  0.448
1990 Cohen ME, Reinlib L, Watson AJ, Gorelick F, Rys-Sikora K, Tse M, Rood RP, Czernik AJ, Sharp GW, Donowitz M. Rabbit ileal villus cell brush border Na+/H+ exchange is regulated by Ca2+/calmodulin-dependent protein kinase II, a brush border membrane protein. Proceedings of the National Academy of Sciences of the United States of America. 87: 8990-4. PMID 2174171 DOI: 10.1073/Pnas.87.22.8990  0.387
1990 McGowan K, Piver G, Stoff JS, Donowitz M. Role of prostaglandins and calcium in the effects of Entamoeba histolytica on colonic electrolyte transport. Gastroenterology. 98: 873-80. PMID 2155844 DOI: 10.1016/0016-5085(90)90010-X  0.351
1986 Donowitz M, Welsh MJ. Ca2+ and cyclic AMP in regulation of intestinal Na, K, and Cl transport. Annual Review of Physiology. 48: 135-50. PMID 3010813 DOI: 10.1146/Annurev.Ph.48.030186.001031  0.395
1982 Charney AN, Wallach JD, Donowitz M, Johnstone N. Effect of cycloheximide on corticosteroid-induced changes in colonic function. The American Journal of Physiology. 243: G112-6. PMID 6287851 DOI: 10.1152/Ajpgi.1982.243.2.G112  0.352
1978 Charney AN, Donowitz M, Costenbader CL. Effect of spironolactone on mineralo and glucocorticoid — induced increases in colonic NA and water absorption and Na-K-ATPase activity Gastroenterology. 74: 1018. DOI: 10.1016/0016-5085(78)93063-9  0.344
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