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Mingdong Huang - Publications

Affiliations: 
BIDMC 
Area:
plasminogen activation
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94 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Yan W, Li H, Ning J, Huang S, Jiang L, Xu P, Huang M, Yuan C. Engineered protein cages with enhanced extracellular drug release for elevated antitumor efficacy. International Journal of Biological Macromolecules. 131492. PMID 38604418 DOI: 10.1016/j.ijbiomac.2024.131492  0.596
2024 Chen S, Fang S, Zhou Y, Huang Z, Yu S, Chen D, Wang Z, Xu Y, Liu P, Li Y, Lin W, Jiang L, Yuan C, Huang M. A low bleeding risk thrombolytic agent: citPA5. Cardiovascular Research. PMID 38546342 DOI: 10.1093/cvr/cvae060  0.568
2023 Xie S, Yang G, Wu J, Jiang L, Yuan C, Xu P, Huang M, Liu Y, Li J. screening of natural products as uPAR inhibitors via multiple structure-based docking and molecular dynamics simulations. Journal of Biomolecular Structure & Dynamics. 1-12. PMID 38111151 DOI: 10.1080/07391102.2023.2295386  0.657
2023 Xu Y, Hu Y, Wu G, Niu L, Fang C, Li Y, Jiang L, Yuan C, Huang M. Specific inhibition on PAI-1 reduces the dose of Alteplase for ischemic stroke treatment. International Journal of Biological Macromolecules. 257: 128618. PMID 38070813 DOI: 10.1016/j.ijbiomac.2023.128618  0.617
2023 Zhao H, Huang M, Jiang L. Potential Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases. International Journal of Molecular Sciences. 24. PMID 38003338 DOI: 10.3390/ijms242216149  0.59
2023 Wang Y, Luo Z, Morelli X, Xu P, Jiang L, Shi X, Huang M. Crystal Structures of Human Serum Albumin in Complex with Lysophosphatidylcholine. Biophysical Journal. PMID 37731243 DOI: 10.1016/j.bpj.2023.09.007  0.635
2023 Mai Y, Wang Z, Zhou Y, Wang G, Chen J, Lin Y, Ji P, Zhang W, Jing Q, Chen L, Chen Z, Lin H, Jiang L, Yuan C, Xu P, ... Huang M, et al. From disinfectants to antibiotics: Enhanced biosafety of quaternary ammonium compounds by chemical modification. Journal of Hazardous Materials. 460: 132454. PMID 37703742 DOI: 10.1016/j.jhazmat.2023.132454  0.628
2023 Liu D, Jiang L, Chen J, Chen Z, Yuan C, Lin D, Huang M. Monomer and Oligomer Transition of Zinc Phthalocyanine Is Key for Photobleaching in Photodynamic Therapy. Molecules (Basel, Switzerland). 28. PMID 37375194 DOI: 10.3390/molecules28124639  0.583
2023 Liao X, Ji P, Chi K, Chen X, Zhou Y, Chen S, Cheng Y, Flaumenhaft R, Yuan C, Huang M. Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex. Rsc Advances. 13: 11464-11471. PMID 37063725 DOI: 10.1039/d3ra01135f  0.53
2023 Xu Y, Chen D, Liu P, Hu Y, Peng S, Chen S, Li Y, Lin W, Jiang L, Yuan C, Huang M. A triple fusion tissue-type plasminogen activator (TriF-ΔtPA) enhanced thrombolysis in carotid embolism-induced stroke model. International Journal of Pharmaceutics. 122878. PMID 36958614 DOI: 10.1016/j.ijpharm.2023.122878  0.631
2023 Zhou Y, Song M, Xie D, Yan S, Yu S, Xie S, Cai M, Li H, Shang L, Jiang L, Yuan C, Huang M, Li J, Xu P. Structural Dynamics-Driven Discovery of Anticancer and Antimetastatic Effects of Diltiazem and Glibenclamide Targeting Urokinase Receptor. Journal of Medicinal Chemistry. PMID 36854648 DOI: 10.1021/acs.jmedchem.2c01663  0.626
2023 Li H, Wang Z, Yu S, Chen S, Zhou Y, Qu Y, Xu P, Jiang L, Yuan C, Huang M. Albumin-based drug carrier targeting urokinase receptor for cancer therapy. International Journal of Pharmaceutics. 122636. PMID 36696930 DOI: 10.1016/j.ijpharm.2023.122636  0.622
2022 Zhou Y, Yu S, Chen D, Li H, Xu P, Yuan C, Jiang L, Huang M. Nafamostat Mesylate in Combination with the Mouse Amino-Terminal Fragment of Urokinase-Human Serum Albumin Improves the Treatment Outcome of Triple-Negative Breast Cancer Therapy. Molecular Pharmaceutics. PMID 36463525 DOI: 10.1021/acs.molpharmaceut.2c00297  0.63
2022 Wang G, Yang L, Jiang L, Chen J, Jing Q, Mai Y, Deng L, Lin Y, Chen L, Chen Z, Xu P, Jiang L, Yuan C, Huang M. A new class of quaternary ammonium compounds as potent and environmental friendly disinfectants. Journal of Cleaner Production. 134632. PMID 36246409 DOI: 10.1016/j.jclepro.2022.134632  0.586
2022 Lin Y, Chen J, Mai Y, Chen L, Chen Z, Wang G, Deng L, Xu P, Yuan C, Jiang L, Huang M. Double-Grafted PET Fiber Material to Remove Airborne Bacteria with High Efficiency. Acs Applied Materials & Interfaces. PMID 36214495 DOI: 10.1021/acsami.2c13358  0.549
2022 Zhou Y, Wu J, Xue G, Li J, Jiang L, Huang M. Structural study of the uPA-nafamostat complex reveals a covalent inhibitory mechanism of nafamostat. Biophysical Journal. PMID 36039386 DOI: 10.1016/j.bpj.2022.08.034  0.633
2022 Chen J, Jing Q, Xu Y, Lin Y, Mai Y, Chen L, Wang G, Chen Z, Deng L, Chen J, Yuan C, Jiang L, Xu P, Huang M. Functionalized zinc oxide microparticles for improving the antimicrobial effects of skin-care products and wound-care medicines. Biomaterials Advances. 135: 212728. PMID 35929206 DOI: 10.1016/j.bioadv.2022.212728  0.578
2022 Chen S, Yuan C, Jiang L, Luo Z, Huang M. Crystallographic analysis of interaction between cisplatin and human serum albumin: Effect of fatty acid. International Journal of Biological Macromolecules. 216: 172-178. PMID 35788007 DOI: 10.1016/j.ijbiomac.2022.06.181  0.607
2022 Wang R, Yang M, Jiang L, Huang M. Role of Angiopoietin-Tie axis in vascular and lymphatic systems and therapeutic interventions. Pharmacological Research. 106331. PMID 35772646 DOI: 10.1016/j.phrs.2022.106331  0.583
2022 Chen D, Liu Y, Liu P, Zhou Y, Jiang L, Yuan C, Huang M. Orally delivered rutin in lipid-based nano-formulation exerts strong antithrombotic effects by protein disulfide isomerase inhibition. Drug Delivery. 29: 1824-1835. PMID 35674505 DOI: 10.1080/10717544.2022.2083726  0.639
2022 Liao X, Zhuang X, Liang C, Li J, Flaumenhaft R, Yuan C, Huang M. Flavonoids as Protein Disulfide Isomerase Inhibitors: Key Molecular and Structural Features for the Interaction. Journal of Agricultural and Food Chemistry. 70: 4475-4483. PMID 35377153 DOI: 10.1021/acs.jafc.1c07994  0.588
2022 Yu S, Sui Y, Wang J, Li Y, Li H, Cao Y, Chen L, Jiang L, Yuan C, Huang M. Crystal structure and cellular functions of uPAR dimer. Nature Communications. 13: 1665. PMID 35351875 DOI: 10.1038/s41467-022-29344-y  0.632
2022 Chen D, Liu P, Liu Y, Wang Z, Zhou Y, Jiang L, Yuan C, Li Y, Lin W, Huang M. A Clot-homing Near-infrared Probe for in vivo Imaging of Murine Thromboembolic Models. Advanced Healthcare Materials. e2102213. PMID 34994110 DOI: 10.1002/adhm.202102213  0.573
2021 S El Salamouni N, Buckley BJ, Jiang L, Huang M, Ranson M, Kelso MJ, Yu H. Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA). Journal of Medicinal Chemistry. PMID 34898192 DOI: 10.1021/acs.jmedchem.1c01423  0.621
2021 Liang C, Flaumenhaft R, Yuan C, Huang M. Vascular thiol isomerases: structures, regulatory mechanisms, and inhibitor development. Drug Discovery Today. PMID 34757205 DOI: 10.1016/j.drudis.2021.10.018  0.53
2021 Wang R, Huang M, Xu Y, Yuan C, Huang M, Jiang L. [Advances of Angiopoietin-Tie axis in vascular and lymphatic system-related diseases]. Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology. 37: 2633-2644. PMID 34472284 DOI: 10.13345/j.cjb.200522  0.573
2021 Yu S, Sun G, Sui Y, Li H, Mai Y, Wang G, Zhang N, Bi Y, Gao GF, Xu P, Jiang L, Yuan C, Yang Y, Huang M. Potent inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 by photosensitizers compounds. Dyes and Pigments : An International Journal. 194: 109570. PMID 34183871 DOI: 10.1016/j.dyepig.2021.109570  0.583
2021 Sun G, Sui Y, Zhou Y, Ya J, Yuan C, Jiang L, Huang M. Structural basis of covalent inhibitory mechanism of TMPRSS2-related serine proteases by camostat. Journal of Virology. JVI0086121. PMID 34160253 DOI: 10.1128/JVI.00861-21  0.671
2021 Zhang D, Chen J, Jing Q, Chen Z, Ullah A, Jiang L, Zheng K, Yuan C, Huang M. Development of a Potent Antimicrobial Peptide With Photodynamic Activity. Frontiers in Microbiology. 12: 624465. PMID 34140932 DOI: 10.3389/fmicb.2021.624465  0.599
2021 Sun G, Yang M, Jiang L, Huang M. Regulation of pro-σ activation: a key checkpoint in Bacillus subtilis sporulation. Environmental Microbiology. PMID 33538382 DOI: 10.1111/1462-2920.15415  0.593
2021 Yuan C, Guo Z, Yu S, Jiang L, Huang M. Development of inhibitors for uPAR: blocking the interaction of uPAR with its partners. Drug Discovery Today. PMID 33486111 DOI: 10.1016/j.drudis.2021.01.016  0.629
2021 Jiang L, Yuan C, Huang M. A general strategy to inhibit serine protease by targeting its autolysis loop. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 35: e21259. PMID 33417271 DOI: 10.1096/fj.202002139RR  0.655
2020 Zhou Y, Chen D, Xue G, Yu S, Yuan C, Huang M, Jiang L. Improved therapeutic efficacy of quercetin-loaded polymeric nanoparticles on triple-negative breast cancer by inhibiting uPA. Rsc Advances. 10: 34517-34526. PMID 35514369 DOI: 10.1039/d0ra04231e  0.594
2020 Huang M, Li L, Shen J, Wang Y, Wang R, Yuan C, Huang M, Jiang L. Plasma levels of the active form of suPAR are associated with COVID-19 severity. Critical Care (London, England). 24: 704. PMID 33372603 DOI: 10.1186/s13054-020-03336-0  0.566
2020 Li L, Huang M, Shen J, Wang Y, Wang R, Yuan C, Jiang L, Huang M. Serum Levels of Soluble Platelet Endothelial Cell Adhesion Molecule 1 in COVID-19 Patients Are Associated With Disease Severity. The Journal of Infectious Diseases. PMID 33179035 DOI: 10.1093/infdis/jiaa642  0.568
2020 Xu Y, Chen S, Chen D, Peng S, Cheng Y, Li J, Li Y, Jiang L, Yuan C, Huang M. [Recent progress in developing of thrombolytic agents for ischemic stroke]. Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology. 36: 2029-2039. PMID 33169568 DOI: 10.13345/j.cjb.200107  0.578
2020 Jiang Y, Lin L, Chen S, Jiang L, Kriegbaum MC, Gårdsvoll H, Hansen LV, Li J, Ploug M, Yuan C, Huang M. Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain. International Journal of Biological Sciences. 16: 981-993. PMID 32140067 DOI: 10.7150/ijbs.39919  0.642
2020 Xue G, Xie X, Zhou Y, Yuan C, Huang M, Jiang L. Insight to the residue in P2 position prevents the peptide inhibitor from being hydrolyzed by serine proteases. Bioscience, Biotechnology, and Biochemistry. 1-7. PMID 32019421 DOI: 10.1080/09168451.2020.1723405  0.651
2020 Li L, Chen D, Zheng K, Jiang L, Dai T, Yang L, Jiang L, Chen Z, Yuan C, Huang M. Enhanced antitumor efficacy and imaging application of photosensitizer-formulated Paclitaxel. Acs Applied Materials & Interfaces. PMID 31909969 DOI: 10.1021/acsami.9b18396  0.601
2019 Buckley BJ, Majed H, Aboelela A, Minaei E, Jiang L, Fildes K, Cheung CY, Johnson D, Bachovchin D, Cook GM, Huang M, Ranson M, Kelso MJ. 6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease. Bioorganic & Medicinal Chemistry Letters. 126753. PMID 31679971 DOI: 10.1016/j.bmcl.2019.126753  0.645
2019 Zuo K, Qi Y, Yuan C, Jiang L, Xu P, Hu J, Huang M, Li J. Specifically targeting cancer proliferation and metastasis processes: the development of matriptase inhibitors. Cancer Metastasis Reviews. PMID 31471691 DOI: 10.1007/s10555-019-09802-8  0.653
2019 Jiang L, Xie X, Li J, Persson E, Huang M. Crystal structure, epitope, and functional impact of an antibody against a superactive FVIIa provide insights into allosteric mechanism. Research and Practice in Thrombosis and Haemostasis. 3: 412-419. PMID 31294329 DOI: 10.1002/rth2.12211  0.631
2019 Xie X, Guo N, Xue G, Xie D, Yuan C, Harrison J, Li J, Jiang L, Huang M. Solution Structure of SpoIVB Reveals Mechanism of PDZ Domain-Regulated Protease Activity. Frontiers in Microbiology. 10: 1232. PMID 31244791 DOI: 10.3389/fmicb.2019.01232  0.645
2019 Liu M, Lin L, Hansen GH, Ploug M, Hanlin L, Jiang L, Yuan C, Li J, Huang M. Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit. Febs Letters. PMID 31044429 DOI: 10.1002/1873-3468.13397  0.674
2019 Li R, Liang C, Jiang L, Yuan C, Huang M. Structural determination of group A Streptococcal surface dehydrogenase and characterization of its interaction with urokinase-type plasminogen activator receptor. Biochemical and Biophysical Research Communications. PMID 30737033 DOI: 10.1016/j.bbrc.2019.01.102  0.611
2019 Wang D, Yang Y, Jiang LX, Wang Y, Li J, Andreasen PA, Chen Z, Huang M, Xu P. Suppression of Tumor Growth and Metastases by Targeted Intervention in Urokinase Activity with Cyclic Peptides. Journal of Medicinal Chemistry. PMID 30707839 DOI: 10.1021/Acs.Jmedchem.8B01908  0.634
2018 Jiang L, Zhang X, Zhou Y, Chen Y, Luo Z, Li J, Yuan C, Huang M. Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases. Rsc Advances. 8: 28189-28197. PMID 35542712 DOI: 10.1039/c8ra03145b  0.652
2018 Wang X, Xue G, Song M, Xu P, Chen D, Yuan C, Lin L, Flaumenhaft R, Li J, Huang M. Molecular basis of rutin inhibition of protein disulfide isomerase (PDI) by combined and experimental methods. Rsc Advances. 8: 18480-18491. PMID 35541126 DOI: 10.1039/c8ra02683a  0.628
2018 Lin H, Chen J, Zhang Y, Ulla A, Liu J, Lin F, Jiang L, Huang M. Enhanced anti-microbial effect through cationization of a mono-triazatricyclodecane substituted asymmetric phthalocyanine. Journal of Inorganic Biochemistry. 189: 192-198. PMID 30317065 DOI: 10.1016/j.jinorgbio.2018.10.001  0.586
2018 Buckley BJ, Aboelela A, Minaei E, Jiang L, Xu Z, Ali U, Fildes K, Cheung CY, Cook SM, Johnson D, Bachovchin DA, Cook GM, Apte M, Huang M, Ranson M, et al. 6-Substituted hexamethylene amiloride (HMA) derivatives as potent and selective inhibitors of the human urokinase plasminogen activator for use in cancer. Journal of Medicinal Chemistry. PMID 30130401 DOI: 10.1021/acs.jmedchem.8b00838  0.634
2018 Xu M, Chen Y, Xu P, Andreasen PA, Jiang L, Li J, Huang M. Crystal Structure of Plasma Kallikrein Provides Insights into the Unusual Flexibility of the S1 Pocket Triggered by Glu217. Febs Letters. PMID 30019481 DOI: 10.1002/1873-3468.13191  0.655
2018 Jiang L, Oldenburg E, Kromann-Hansen T, Xu P, Jensen JK, Andreasen PA, Huang M. Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition. Biochimica Et Biophysica Acta. PMID 29959058 DOI: 10.1016/j.bbagen.2018.06.016  0.633
2018 Li R, Ma H, Jiang L, Qiao S, Zhi Y, Huang M, Deng R, Zhang G. The CD163 long-range scavenger receptor cysteine-rich repeat: expression, purification and X-ray crystallographic characterization. Acta Crystallographica. Section F, Structural Biology Communications. 74: 322-326. PMID 29718001 DOI: 10.1107/S2053230X18005551  0.59
2018 Li S, Li L, Chen Z, Xue G, Jiang L, Zheng K, Chen J, Li R, Yuan C, Huang M. A novel purification procedure for recombinant human serum albumin expressed in pichia pastoris. Protein Expression and Purification. PMID 29678737 DOI: 10.1016/j.pep.2018.04.012  0.601
2018 Jia Y, Li J, Chen J, Hu P, Jiang L, Chen X, Huang M, Chen Z, Xu P. A Smart Photosensitizer: Tumor-triggered Oncotherapy by Self-Assembly Photodynamic Nanodots. Acs Applied Materials & Interfaces. PMID 29652473 DOI: 10.1021/acsami.7b19058  0.596
2017 Xue G, Gong L, Yuan C, Xu M, Wang X, Jiang L, Huang M. A structural mechanism of flavonoids in inhibiting serine proteases. Food & Function. PMID 28644504 DOI: 10.1039/c6fo01825d  0.671
2017 Kromann-Hansen T, Louise Lange E, Peter Sørensen H, Hassanzadeh-Ghassabeh G, Huang M, Jensen JK, Muyldermans S, Declerck PJ, Komives EA, Andreasen PA. Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Scientific Reports. 7: 3385. PMID 28611361 DOI: 10.1038/S41598-017-03457-7  0.311
2017 Peng S, Xue G, Gong L, Fang C, Chen J, Yuan C, Chen Z, Yao L, Furie B, Huang M. A long-acting PAI-1 inhibitor reduce thrombus formation. Thrombosis and Haemostasis. PMID 28405670 DOI: 10.1160/Th16-11-0891  0.55
2017 Liu M, Yuan C, Jensen J, Zhao B, Jiang Y, Jiang L, Huang M. The Crystal Structure of a Membrane-bound Multi-domain Protease Inhibitor Reveals the Mechanism of Its Auto-inhibition. The Journal of Biological Chemistry. PMID 28348076 DOI: 10.1074/jbc.M117.779256  0.672
2017 Liu M, Yuan C, Jiang Y, Jiang L, Huang M. Recombinant hepatocyte growth factor activator inhibitor 1: expression in Drosophila S2 cells, purification and crystallization. Acta Crystallographica. Section F, Structural Biology Communications. 73: 45-50. PMID 28045393 DOI: 10.1107/S2053230X16020082  0.636
2016 Ma H, Jiang L, Qiao S, Zhi Y, Chen XX, Yang Y, Huang X, Huang M, Li R, Zhang GP. Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain (SRCR5) from Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection. Journal of Virology. PMID 27881657 DOI: 10.1128/JVI.01897-16  0.613
2016 Bekendam RH, Bendapudi PK, Lin L, Nag PP, Pu J, Kennedy DR, Feldenzer A, Chiu J, Cook KM, Furie B, Huang M, Hogg PJ, Flaumenhaft R. A substrate-driven allosteric switch that enhances PDI catalytic activity. Nature Communications. 7: 12579. PMID 27573496 DOI: 10.1038/Ncomms12579  0.694
2016 Jiang L, Lin L, Li R, Yuan C, Xu M, Huang JH, Huang M. Dimer conformation of soluble PECAM-1, an endothelial marker. The International Journal of Biochemistry & Cell Biology. PMID 27270333 DOI: 10.1016/j.biocel.2016.06.001  0.663
2016 Yuan C, Jürgensen HJ, Engelholm LH, Li R, Liu M, Jiang L, Luo Z, Behrendt N, Huang M. Crystal structures of the ligand binding region of uPARAP: effect of calcium ion binding. The Biochemical Journal. PMID 27247422 DOI: 10.1042/BCJ20160276  0.624
2016 Gong L, Proulle V, Fang C, Hong Z, Lin Z, Liu M, Xue G, Yuan C, Lin L, Furie B, Flaumenhaft R, Andreasen P, Furie B, Huang M. A specific plasminogen activator inhibitor-1 antagonist derived from inactivated urokinase. Journal of Cellular and Molecular Medicine. PMID 27197780 DOI: 10.1111/Jcmm.12875  0.704
2015 Jiang L, Andersen LM, Andreasen PA, Chen L, Huang M. Insights into the serine protease mechanism based on structural observations of the conversion of a peptidyl serine protease inhibitor to a substrate. Biochimica Et Biophysica Acta. PMID 26691138 DOI: 10.1016/J.Bbagen.2015.12.009  0.635
2015 Xu P, Xu M, Jiang L, Yang Q, Luo Z, Dauter Z, Huang M, Andreasen PA. Design of Specific Serine Protease Inhibitors Based on a Versatile Peptide Scaffold: Conversion of a Urokinase Inhibitor to a Plasma Kallikrein Inhibitor. Journal of Medicinal Chemistry. PMID 26536069 DOI: 10.1021/acs.jmedchem.5b01128  0.654
2015 Sørensen HP, Xu P, Jiang L, Kromann-Hansen T, Jensen KJ, Huang M, Andreasen PA. Selection of High Affinity Peptidic Serine Protease Inhibitors with Increased Binding Entropy from a Back-Flip Library of Peptide-Protein Fusions. Journal of Molecular Biology. PMID 26281711 DOI: 10.1016/j.jmb.2015.08.005  0.644
2015 Lin L, Gopal S, Sharda A, Passam F, Bowley SR, Stopa J, Xue G, Yuan C, Furie BC, Flaumenhaft R, Huang M, Furie B. Quercetin-3-rutinoside Inhibits Protein Disulfide Isomerase by Binding to Its b'x Domain. The Journal of Biological Chemistry. 290: 23543-52. PMID 26240139 DOI: 10.1074/Jbc.M115.666180  0.688
2015 Jiang L, Zhao B, Xu P, Sørensen HP, Jensen JK, Christensen A, Hosseini M, Nielsen NC, Jensen KJ, Andreasen PA, Huang M. Distinctive binding modes and inhibitory mechanisms of two peptidic inhibitors of urokinase-type plasminogen activator with isomeric P1 residues. The International Journal of Biochemistry & Cell Biology. 62: 88-92. PMID 25744057 DOI: 10.1016/j.biocel.2015.02.016  0.641
2015 Passam FH, Lin L, Gopal S, Stopa JD, Bellido-Martin L, Huang M, Furie BC, Furie B. Both platelet- and endothelial cell-derived ERp5 support thrombus formation in a laser-induced mouse model of thrombosis. Blood. 125: 2276-85. PMID 25624318 DOI: 10.1182/Blood-2013-12-547208  0.558
2015 Aisiku O, Peters CG, De Ceunynck K, Ghosh CC, Dilks JR, Fustolo-Gunnink SF, Huang M, Dockendorff C, Parikh SM, Flaumenhaft R. Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar. Blood. 125: 1976-85. PMID 25587041 DOI: 10.1182/Blood-2014-09-599910  0.541
2014 Zhao B, Xu P, Jiang L, Paaske B, Kromann-Hansen T, Jensen JK, Sørensen HP, Liu Z, Nielsen JT, Christensen A, Hosseini M, Sørensen KK, Nielsen NC, Jensen KJ, Huang M, et al. A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility. Plos One. 9: e115872. PMID 25545505 DOI: 10.1371/journal.pone.0115872  0.653
2014 Chen Z, Xu P, Chen J, Chen H, Hu P, Chen X, Lin L, Huang Y, Zheng K, Zhou S, Li R, Chen S, Liu J, Xue J, Huang M. Zinc phthalocyanine conjugated with the amino-terminal fragment of urokinase for tumor-targeting photodynamic therapy. Acta Biomaterialia. 10: 4257-68. PMID 24969665 DOI: 10.1016/j.actbio.2014.06.026  0.314
2013 Roodbeen R, Paaske B, Jiang L, Jensen JK, Christensen A, Nielsen JT, Huang M, Mulder FA, Nielsen NC, Andreasen PA, Jensen KJ. Bicyclic peptide inhibitor of urokinase-type plasminogen activator: mode of action. Chembiochem : a European Journal of Chemical Biology. 14: 2179-88. PMID 24115455 DOI: 10.1002/Cbic.201300335  0.622
2013 Jiang L, Botkjaer KA, Andersen LM, Yuan C, Andreasen PA, Huang M. Rezymogenation of active urokinase induced by an inhibitory antibody. The Biochemical Journal. 449: 161-6. PMID 23016918 DOI: 10.1042/BJ20121132  0.644
2012 Cho J, Kennedy DR, Lin L, Huang M, Merrill-Skoloff G, Furie BC, Furie B. Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of β3 integrins. Blood. 120: 647-55. PMID 22653978 DOI: 10.1182/Blood-2011-08-372532  0.503
2012 Xu X, Gårdsvoll H, Yuan C, Lin L, Ploug M, Huang M. Crystal structure of the urokinase receptor in a ligand-free form. Journal of Molecular Biology. 416: 629-41. PMID 22285761 DOI: 10.1016/j.jmb.2011.12.058  0.378
2011 Jiang L, Svane AS, Sørensen HP, Jensen JK, Hosseini M, Chen Z, Weydert C, Nielsen JT, Christensen A, Yuan C, Jensen KJ, Nielsen NC, Malmendal A, Huang M, Andreasen PA. The binding mechanism of a peptidic cyclic serine protease inhibitor. Journal of Molecular Biology. 412: 235-50. PMID 21802428 DOI: 10.1016/j.jmb.2011.07.028  0.656
2011 Hosseini M, Jiang L, Sørensen HP, Jensen JK, Christensen A, Fogh S, Yuan C, Andersen LM, Huang M, Andreasen PA, Jensen KJ. Elucidation of the contribution of active site and exosite interactions to affinity and specificity of peptidylic serine protease inhibitors using non-natural arginine analogs. Molecular Pharmacology. 80: 585-97. PMID 21719463 DOI: 10.1124/mol.111.072280  0.66
2011 Ngo JC, Jiang L, Lin Z, Yuan C, Chen Z, Zhang X, Yu H, Wang J, Lin L, Huang M. Structural basis for therapeutic intervention of uPA/uPAR system. Current Drug Targets. 12: 1729-43. PMID 21707478  0.692
2011 Lin Z, Jiang L, Yuan C, Jensen JK, Zhang X, Luo Z, Furie BC, Furie B, Andreasen PA, Huang M. Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1. The Journal of Biological Chemistry. 286: 7027-32. PMID 21199867 DOI: 10.1074/Jbc.M110.204537  0.728
2010 Bian C, Yuan C, Chen L, Meehan EJ, Jiang L, Huang Z, Lin L, Huang M. Crystal structure of a triacylglycerol lipase from Penicillium expansum at 1.3 A determined by sulfur SAD. Proteins. 78: 1601-5. PMID 20146362 DOI: 10.1002/Prot.22676  0.637
2010 Lin L, Gårdsvoll H, Huai Q, Huang M, Ploug M. Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. The Journal of Biological Chemistry. 285: 10982-92. PMID 20133942 DOI: 10.1074/jbc.M109.093492  0.37
2010 Liu Z, Lin L, Yuan C, Nicolaes GA, Chen L, Meehan EJ, Furie B, Furie B, Huang M. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. The Journal of Biological Chemistry. 285: 8824-9. PMID 20089867 DOI: 10.1074/Jbc.M109.080168  0.572
2010 Chen Z, Lin L, Huai Q, Huang M. Challenges for drug discovery - a case study of urokinase receptor inhibition. Combinatorial Chemistry & High Throughput Screening. 12: 961-7. PMID 20025562 DOI: 10.2174/138620709789824727  0.372
2009 Guo S, Shi X, Yang F, Chen L, Meehan EJ, Bian C, Huang M. Structural basis of transport of lysophospholipids by human serum albumin. The Biochemical Journal. 423: 23-30. PMID 19601929 DOI: 10.1042/Bj20090913  0.681
2008 Ngo JC, Huang M, Roth DA, Furie BC, Furie B. Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex. Structure (London, England : 1993). 16: 597-606. PMID 18400180 DOI: 10.1016/j.str.2008.03.001  0.485
2008 Huai Q, Zhou A, Lin L, Mazar AP, Parry GC, Callahan J, Shaw DE, Furie B, Furie BC, Huang M. Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes. Nature Structural & Molecular Biology. 15: 422-3. PMID 18376415 DOI: 10.1038/Nsmb.1404  0.539
2007 Zhao G, Yuan C, Wind T, Huang Z, Andreasen PA, Huang M. Structural basis of specificity of a peptidyl urokinase inhibitor, upain-1. Journal of Structural Biology. 160: 1-10. PMID 17692534 DOI: 10.1016/j.jsb.2007.06.003  0.321
2007 Lin L, Huai Q, Huang M, Furie B, Furie BC. Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII. Journal of Molecular Biology. 371: 717-24. PMID 17583728 DOI: 10.1016/J.Jmb.2007.05.054  0.538
2006 Huai Q, Mazar AP, Kuo A, Parry GC, Shaw DE, Callahan J, Li Y, Yuan C, Bian C, Chen L, Furie B, Furie BC, Cines DB, Huang M. Structure of human urokinase plasminogen activator in complex with its receptor. Science (New York, N.Y.). 311: 656-9. PMID 16456079 DOI: 10.1126/Science.1121143  0.5
2004 Huang M, Furie BC, Furie B. Crystal structure of the calcium-stabilized human factor IX Gla domain bound to a conformation-specific anti-factor IX antibody. The Journal of Biological Chemistry. 279: 14338-46. PMID 14722079 DOI: 10.1074/Jbc.M314011200  0.496
2003 Huang M, Rigby AC, Morelli X, Grant MA, Huang G, Furie B, Seaton B, Furie BC. Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins. Nature Structural Biology. 10: 751-6. PMID 12923575 DOI: 10.1038/Nsb971  0.5
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