| Year |
Citation |
Score |
| 2022 |
Bavinton CE, Sternke-Hoffmann R, Yamashita T, Knipe PC, Hamilton AD, Luo J, Thompson S. Rationally designed helical peptidomimetics disrupt α-synuclein fibrillation. Chemical Communications (Cambridge, England). 58: 5132-5135. PMID 35380562 DOI: 10.1039/d2cc00212d |
0.78 |
|
| 2021 |
Palanikumar L, Karpauskaite L, Al-Sayegh M, Chehade I, Alam M, Hassan S, Maity D, Ali L, Kalmouni M, Hunashal Y, Ahmed J, Houhou T, Karapetyan S, Falls Z, Samudrala R, ... ... Hamilton AD, et al. Protein mimetic amyloid inhibitor potently abrogates cancer-associated mutant p53 aggregation and restores tumor suppressor function. Nature Communications. 12: 3962. PMID 34172723 DOI: 10.1038/s41467-021-23985-1 |
0.515 |
|
| 2020 |
Peacock H, Henriques ST, Benfield AH, Elliott AG, Luo J, Luccarelli J, Nagano M, Craik DJ, Hamilton AD. Antimicrobial peptide mimetics based on a diphenylacetylene scaffold: synthesis, conformational analysis and activity. Chemmedchem. PMID 32754982 DOI: 10.1002/Cmdc.202000474 |
0.769 |
|
| 2019 |
Sebti SM, Kazi A, Xiang S, Yang H, Chen L, Kennedy P, Ayaz M, Fletcher S, Cummings C, Lawrence HR, Beato F, Kang Y, Kim MP, Delitto A, Underwood PW, ... ... Hamilton AD, et al. Dual farnesyl and geranylgeranyl transferase inhibitor thwarts mutant KRAS-driven patient-derived pancreatic tumors. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31227505 DOI: 10.1158/1078-0432.Ccr-18-3399 |
0.716 |
|
| 2019 |
Maity D, Kumar S, Curreli F, Debnath A, Hamilton A. α-Helix-Mimetic Foldamers for Targeting HIV-1 TAR RNA. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 30825250 DOI: 10.1002/Chem.201900139 |
0.553 |
|
| 2019 |
Kazi A, Xiang S, Yang H, Chen L, Kennedy P, Ayaz M, Fletcher S, Cummings C, Lawrence H, Beato F, Yang Y, Kim MP, Delitto A, Underwood P, Fleming JB, ... ... Hamilton AD, et al. Abstract 3088: Farnesyl/geranylgeranyl transferase dual inhibitor thwarts mutant KRas-driven patient-derived pancreatic tumors Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-3088 |
0.706 |
|
| 2019 |
Vogel MC, Kumar S, Maity D, Magzoub MM, Hamilton AD. Inhibition of Zinc-Mediated Amyloid Beta Aggregation and Cytotoxicity by Alpha Helix Mimetics Biophysical Journal. 116: 479a-480a. DOI: 10.1016/J.Bpj.2018.11.2590 |
0.536 |
|
| 2019 |
Maity D, Kumar S, Curreli F, Debnath AK, Hamilton AD. Cover Feature: α‐Helix‐Mimetic Foldamers for Targeting HIV‐1 TAR RNA (Chem. Eur. J. 30/2019) Chemistry – a European Journal. 25: 7230-7230. DOI: 10.1002/Chem.201901752 |
0.501 |
|
| 2018 |
Kumar S, Vogel MC, Hamilton AD. Teaching an old scaffold new recognition tricks: oligopyrrolamide antagonists of IAPP aggregation. Organic & Biomolecular Chemistry. PMID 29303519 DOI: 10.1039/C7Ob02910A |
0.317 |
|
| 2017 |
Luccarelli J, Jones IM, Thompson S, Hamilton AD. Unpicking the determinants of amide NHO[double bond, length as m-dash]C hydrogen bond strength with diphenylacetylene molecular balances. Organic & Biomolecular Chemistry. PMID 29058730 DOI: 10.1039/C7Ob02026K |
0.718 |
|
| 2016 |
Peacock H, Luo J, Yamashita T, Luccarelli J, Thompson S, Hamilton AD. Non-covalent S···O interactions control conformation in a scaffold that disrupts islet amyloid polypeptide fibrillation. Chemical Science. 7: 6435-6439. PMID 28451100 DOI: 10.1039/C6Sc00756B |
0.799 |
|
| 2016 |
Busschaert N, Thompson S, Hamilton AD. An α-helical peptidomimetic scaffold for dynamic combinatorial library formation. Chemical Communications (Cambridge, England). PMID 27892554 DOI: 10.1039/C6Cc07787K |
0.517 |
|
| 2016 |
Knipe PC, Thompson S, Hamilton AD. Acid-mediated topological control in a functionalized foldamer. Chemical Communications (Cambridge, England). PMID 27045691 DOI: 10.1039/C6Cc01496H |
0.773 |
|
| 2016 |
Peacock H, Thinnes CC, Kawamura A, Hamilton AD. Tetracyanoresorcin[4]arene selectively recognises trimethyllysine and inhibits its enzyme-catalysed demethylation Supramolecular Chemistry. 1-7. DOI: 10.1080/10610278.2016.1140898 |
0.651 |
|
| 2015 |
Knipe PC, Thompson S, Hamilton AD. Ion-mediated conformational switches. Chemical Science. 6: 1630-1639. PMID 28694943 DOI: 10.1039/C4Sc03525A |
0.766 |
|
| 2015 |
Yamashita T, Knipe PC, Busschaert N, Thompson S, Hamilton AD. A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26384862 DOI: 10.1002/Chem.201501366 |
0.792 |
|
| 2015 |
Yamashita T, Knipe PC, Busschaert N, Thompson S, Hamilton AD. A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26333029 DOI: 10.1002/chem.201503218 |
0.76 |
|
| 2015 |
Ross JE, Knipe PC, Thompson S, Hamilton AD. Hybrid Diphenylalkyne-Dipeptide Oligomers Induce Multistrand β-Sheet Formation. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26264561 DOI: 10.1002/Chem.201502690 |
0.797 |
|
| 2015 |
Kumar S, Schlamadinger DE, Brown MA, Dunn JM, Mercado B, Hebda JA, Saraogi I, Rhoades E, Hamilton AD, Miranker AD. Islet amyloid-induced cell death and bilayer integrity loss share a molecular origin targetable with oligopyridylamide-based α-helical mimetics. Chemistry & Biology. 22: 369-78. PMID 25754474 DOI: 10.1016/J.Chembiol.2015.01.006 |
0.704 |
|
| 2015 |
German EA, Ross JE, Knipe PC, Don MF, Thompson S, Hamilton AD. β-Strand mimetic foldamers rigidified through Dipolar repulsion. Angewandte Chemie (International Ed. in English). 54: 2649-52. PMID 25599889 DOI: 10.1002/Anie.201410290 |
0.791 |
|
| 2015 |
Jayatunga MK, Thompson S, McKee TC, Chan MC, Reece KM, Hardy AP, Sekirnik R, Seden PT, Cook KM, McMahon JB, Figg WD, Schofield CJ, Hamilton AD. Inhibition of the HIF1α-p300 interaction by quinone- and indandione-mediated ejection of structural Zn(II). European Journal of Medicinal Chemistry. 94: 509-16. PMID 25023609 DOI: 10.1016/J.Ejmech.2014.06.006 |
0.785 |
|
| 2015 |
Knipe PC, Thompson S, Hamilton AD. Ion-mediated conformational switches Chemical Science. 6: 1630-1639. DOI: 10.1039/c4sc03525a |
0.74 |
|
| 2015 |
Kulikov OV, Kumar S, Magzoub M, Knipe PC, Saraogi I, Thompson S, Miranker AD, Hamilton AD. Amphiphilic oligoamide α-helix peptidomimetics inhibit islet amyloid polypeptide aggregation Tetrahedron Letters. DOI: 10.1016/J.Tetlet.2015.02.132 |
0.789 |
|
| 2015 |
Yamashita T, Knipe PC, Busschaert N, Thompson S, Hamilton AD. Cover Picture: A Modular Synthesis of Conformationally Preorganised Extended β-Strand Peptidomimetics (Chem. Eur. J. 42/2015) Chemistry - a European Journal. 21: 14653-14653. DOI: 10.1002/Chem.201584201 |
0.762 |
|
| 2014 |
Knipe PC, Jones IM, Thompson S, Hamilton AD. Remote conformational control of a molecular switch via methylation and deprotonation. Organic & Biomolecular Chemistry. 12: 9384-8. PMID 25317972 DOI: 10.1039/C4Ob01991A |
0.773 |
|
| 2014 |
Knipe PC, Lingard H, Jones IM, Thompson S, Hamilton AD. A Lewis acid-mediated conformational switch. Organic & Biomolecular Chemistry. 12: 7937-41. PMID 25184700 DOI: 10.1039/C4Ob01556H |
0.779 |
|
| 2014 |
Jones IM, Knipe PC, Michaelos T, Thompson S, Hamilton AD. Redox-dependent conformational switching of diphenylacetylenes. Molecules (Basel, Switzerland). 19: 11316-32. PMID 25090120 DOI: 10.3390/Molecules190811316 |
0.772 |
|
| 2014 |
Lingard H, Han JT, Thompson AL, Leung IK, Scott RT, Thompson S, Hamilton AD. Diphenylacetylene-linked peptide strands induce bidirectional β-sheet formation. Angewandte Chemie (International Ed. in English). 53: 3650-3. PMID 24554626 DOI: 10.1002/Anie.201309353 |
0.68 |
|
| 2014 |
Jayatunga MK, Thompson S, Hamilton AD. α-Helix mimetics: outwards and upwards. Bioorganic & Medicinal Chemistry Letters. 24: 717-24. PMID 24433858 DOI: 10.1016/J.Bmcl.2013.12.003 |
0.803 |
|
| 2014 |
Aslamuzzaman K, Zhang X, Luo Y, Patel R, Fletcher S, Cummings C, Lawrence H, Hamilton A, Sebti SM. Abstract B35: Dual inhibitors of FT and GGT-1 as novel therapeutic agents for K-Ras-dependent tumors Molecular Cancer Research. 12. DOI: 10.1158/1557-3125.Rasonc14-B35 |
0.711 |
|
| 2014 |
Lingard H, Han JT, Thompson AL, Leung IKH, Scott RTW, Thompson S, Hamilton AD. Cover Picture: Diphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet Formation (Angew. Chem. Int. Ed. 14/2014) Angewandte Chemie International Edition. 53: 3521-3521. DOI: 10.1002/Anie.201401099 |
0.637 |
|
| 2014 |
Lingard H, Han JT, Thompson AL, Leung IKH, Scott RTW, Thompson S, Hamilton AD. Titelbild: Diphenylacetylene-Linked Peptide Strands Induce Bidirectional β-Sheet Formation (Angew. Chem. 14/2014) Angewandte Chemie. 126: 3591-3591. DOI: 10.1002/Ange.201401099 |
0.635 |
|
| 2013 |
Nevola L, Rodriguez JM, Thompson S, Hamilton AD. Super-secondary structure peptidomimetics: design and synthesis of an α-α hairpin analogue. Supramolecular Chemistry. 25: 586-590. PMID 26052191 DOI: 10.1080/10610278.2013.817581 |
0.701 |
|
| 2013 |
Martucci WE, Rodriguez JM, Vargo MA, Marr M, Hamilton AD, Anderson KS. Exploring novel strategies for AIDS protozoal pathogens: α-helix mimetics targeting a key allosteric protein-protein interaction in C. hominis TS-DHFR. Medchemcomm. 4. PMID 24324854 DOI: 10.1039/C3Md00141E |
0.643 |
|
| 2013 |
Simister PC, Luccarelli J, Thompson S, Appella DH, Feller SM, Hamilton AD. Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen. Bioorganic & Medicinal Chemistry. 21: 4027-33. PMID 23182216 DOI: 10.1016/J.Bmc.2012.10.023 |
0.742 |
|
| 2013 |
Cummings CG, Hamilton AD. Expedient route to functionalized and water soluble 5-6-5 imidazole-phenyl-thiazole based α-helix mimetics Tetrahedron. 69: 1663-1668. DOI: 10.1016/J.Tet.2012.11.070 |
0.739 |
|
| 2013 |
Kulikov OV, Thompson S, Xu H, Incarvito CD, Scott RTW, Saraogi I, Nevola L, Hamilton AD. Design and Synthesis of Oligoamide-Based Double α-Helix Mimetics (Eur. J. Org. Chem. 17/2013) European Journal of Organic Chemistry. 2013: n/a-n/a. DOI: 10.1002/Ejoc.201390045 |
0.764 |
|
| 2013 |
Kulikov OV, Thompson S, Xu H, Incarvito CD, Scott RTW, Saraogi I, Nevola L, Hamilton AD. Design and synthesis of oligoamide-based double α-helix mimetics European Journal of Organic Chemistry. 3433-3445. DOI: 10.1002/Ejoc.201300363 |
0.753 |
|
| 2012 |
Adler MJ, Scott RT, Hamilton AD. Enaminone-based mimics of extended and hydrophilic α-helices. Chemistry (Weinheim An Der Bergstrasse, Germany). 18: 12974-7. PMID 22936425 DOI: 10.1002/Chem.201202120 |
0.611 |
|
| 2012 |
Sutherell CL, Thompson S, Scott RT, Hamilton AD. Aryl-linked imidazolidin-2-ones as non-peptidic β-strand mimetics. Chemical Communications (Cambridge, England). 48: 9834-6. PMID 22936296 DOI: 10.1039/C2Cc34791A |
0.521 |
|
| 2012 |
Ghosh PS, Hamilton AD. Noncovalent template-assisted mimicry of multiloop protein surfaces: assembling discontinuous and functional domains. Journal of the American Chemical Society. 134: 13208-11. PMID 22839643 DOI: 10.1021/Ja305360Q |
0.34 |
|
| 2012 |
Thompson S, Hamilton AD. Amphiphilic α-helix mimetics based on a benzoylurea scaffold. Organic & Biomolecular Chemistry. 10: 5780-2. PMID 22532001 DOI: 10.1039/C2Ob25273B |
0.529 |
|
| 2012 |
Tsou LK, Chen CH, Dutschman GE, Cheng YC, Hamilton AD. Blocking HIV-1 entry by a gp120 surface binding inhibitor. Bioorganic & Medicinal Chemistry Letters. 22: 3358-61. PMID 22487177 DOI: 10.1016/J.Bmcl.2012.02.079 |
0.68 |
|
| 2012 |
Jamieson AG, Russell D, Hamilton AD. A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic. Chemical Communications (Cambridge, England). 48: 3709-11. PMID 22399148 DOI: 10.1039/C2Cc30295K |
0.317 |
|
| 2012 |
Kulikov OV, Hamilton AD. Synthesis of the novel trimeric benzamides - Potential inhibitors of protein-protein interactions Rsc Advances. 2: 2454-2461. DOI: 10.1039/C2Ra01153K |
0.322 |
|
| 2012 |
Thompson S, Vallinayagam R, Adler MJ, Scott RTW, Hamilton AD. Double-sided α-helix mimetics Tetrahedron. 68: 4501-4505. DOI: 10.1016/J.Tet.2011.11.010 |
0.69 |
|
| 2011 |
Adler MJ, Hamilton AD. Oligophenylenaminones as scaffolds for α-helix mimicry. The Journal of Organic Chemistry. 76: 7040-7. PMID 21739975 DOI: 10.1021/Jo200917D |
0.653 |
|
| 2011 |
Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner. The Journal of Biological Chemistry. 286: 9382-92. PMID 21148306 DOI: 10.1074/Jbc.M110.203638 |
0.78 |
|
| 2011 |
Adler MJ, Jamieson AG, Hamilton AD. Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions. Current Topics in Microbiology and Immunology. 348: 1-23. PMID 20827522 DOI: 10.1007/82_2010_91 |
0.645 |
|
| 2011 |
Kazi A, Luo Y, Berndt N, Fletcher S, Cummings C, Lawrence H, Hamilton AD, Sebti SM. Abstract 620: Development of a dual protein farnesyltransferase -geranylgeranyltransferase-I inhibitor with antitumor activity against human cancer cells Cancer Research. 71: 620-620. DOI: 10.1158/1538-7445.Am2011-620 |
0.733 |
|
| 2011 |
Kulikov OV, Incarvito C, Hamilton AD. Hydrophobic side-chain interactions in a family of dimeric amide foldamers-potential alpha-helix mimetics Tetrahedron Letters. 52: 3705-3709. DOI: 10.1016/J.Tetlet.2011.05.004 |
0.356 |
|
| 2010 |
Margulies D, Hamilton AD. Combinatorial protein recognition as an alternative approach to antibody-mimetics. Current Opinion in Chemical Biology. 14: 705-12. PMID 20829097 DOI: 10.1016/J.Cbpa.2010.07.017 |
0.319 |
|
| 2010 |
Fletcher S, Keaney EP, Cummings CG, Blaskovich MA, Hast MA, Glenn MP, Chang SY, Bucher CJ, Floyd RJ, Katt WP, Gelb MH, Van Voorhis WC, Beese LS, Sebti SM, Hamilton AD. Structure-based design and synthesis of potent, ethylenediamine-based, mammalian farnesyltransferase inhibitors as anticancer agents. Journal of Medicinal Chemistry. 53: 6867-88. PMID 20822181 DOI: 10.1021/Jm1001748 |
0.789 |
|
| 2010 |
Cummings CG, Hamilton AD. Disrupting protein-protein interactions with non-peptidic, small molecule alpha-helix mimetics. Current Opinion in Chemical Biology. 14: 341-6. PMID 20430687 DOI: 10.1016/J.Cbpa.2010.04.001 |
0.752 |
|
| 2010 |
Rosenzweig BA, Ross NT, Adler MJ, Hamilton AD. Altered binding of a multimeric protein by changing the self-assembling properties of its substrate. Journal of the American Chemical Society. 132: 6749-54. PMID 20415446 DOI: 10.1021/Ja100485N |
0.753 |
|
| 2010 |
Tsou LK, Dutschman GE, Gullen EA, Telpoukhovskaia M, Cheng YC, Hamilton AD. Discovery of a synthetic dual inhibitor of HIV and HCV infection based on a tetrabutoxy-calix[4]arene scaffold. Bioorganic & Medicinal Chemistry Letters. 20: 2137-9. PMID 20202840 DOI: 10.1016/J.Bmcl.2010.02.043 |
0.667 |
|
| 2010 |
Saha S, Cai J, Eiler D, Hamilton AD. Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions. Chemical Communications (Cambridge, England). 46: 1685-7. PMID 20177616 DOI: 10.1039/B915955J |
0.413 |
|
| 2010 |
Ross NT, Katt WP, Hamilton AD. Synthetic mimetics of protein secondary structure domains. Philosophical Transactions. Series a, Mathematical, Physical, and Engineering Sciences. 368: 989-1008. PMID 20123744 DOI: 10.1098/Rsta.2009.0210 |
0.703 |
|
| 2010 |
Cai J, Niedzwiedzki DM, Frank HA, Hamilton AD. Ultrafast energy transfer within pyropheophorbide-a tethered to self-assembling DNA quadruplex. Chemical Communications (Cambridge, England). 46: 544-6. PMID 20062856 DOI: 10.1039/B908435E |
0.394 |
|
| 2010 |
Saraogi I, Hebda JA, Becerril J, Estroff LA, Miranker AD, Hamilton AD. Synthetic alpha-helix mimetics as agonists and antagonists of islet amyloid polypeptide aggregation. Angewandte Chemie (International Ed. in English). 49: 736-9. PMID 20029853 DOI: 10.1002/Anie.200901694 |
0.783 |
|
| 2010 |
Cheng Y, Tsou LK, Cai J, Aya T, Dutschman GE, Gullen EA, Grill SP, Chen AP, Lindenbach BD, Hamilton AD, Cheng YC. A novel class of meso-tetrakis-porphyrin derivatives exhibits potent activities against hepatitis C virus genotype 1b replicons in vitro. Antimicrobial Agents and Chemotherapy. 54: 197-206. PMID 19901090 DOI: 10.1128/Aac.01206-09 |
0.714 |
|
| 2010 |
Yang H, Wang D, Hamilton AD, Sebti SM. Abstract 3675: Farnesyltransferase inhibitor (FTI) disruption of Rheb/FKBP38 association leads to FKBP38-mediated inactivation of mTOR Cancer Research. 70: 3675-3675. DOI: 10.1158/1538-7445.Am10-3675 |
0.32 |
|
| 2010 |
LINTON B, HAMILTON AD. ChemInform Abstract: Formation of Artificial Receptors by Metal-Templated Self-Assembly Cheminform. 28: no-no. DOI: 10.1002/chin.199744318 |
0.705 |
|
| 2010 |
LINTON B, HAMILTON A. ChemInform Abstract: Receptors That Assemble Themselves Cheminform. 28: no-no. DOI: 10.1002/CHIN.199739320 |
0.705 |
|
| 2010 |
HAMILTON AD, FAN E, VAN ARMAN S, VICENT C, TELLADO FG, GEIB SJ. ChemInform Abstract: Molecular Recognition. Design of New Receptors for Complexation and Catalysis Cheminform. 25: no-no. DOI: 10.1002/chin.199426309 |
0.441 |
|
| 2010 |
HIRST SC, TECILLA P, GEIB SJ, FAN E, HAMILTON AD. ChemInform Abstract: Molecular Recognition of Phosphate Esters: A Balance of Hydrogen Bonding and Proton Transfer Interactions. Cheminform. 24: no-no. DOI: 10.1002/chin.199310045 |
0.433 |
|
| 2010 |
CHANG S, VAN ENGEN D, FAN E, HAMILTON AD. ChemInform Abstract: Hydrogen Bonding and Molecular Recognition: Synthetic, Complexation, and Structural Studies on Barbiturate Binding to an Artificial Receptor Cheminform. 23: no-no. DOI: 10.1002/chin.199201057 |
0.472 |
|
| 2010 |
Becerril J, Rodriguez JM, Wyrembak PN, Hamilton AD. Inhibition of Protein-Protein Interactions by Peptide Mimics Protein Surface Recognition: Approaches For Drug Discovery. 105-131. DOI: 10.1002/9780470972137.ch5 |
0.788 |
|
| 2009 |
Jain RK, Tsou LK, Hamilton AD. Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates. Tetrahedron Letters. 50: 2787-2789. PMID 20352130 DOI: 10.1016/J.Tetlet.2009.03.153 |
0.734 |
|
| 2009 |
Hebda JA, Saraogi I, Magzoub M, Hamilton AD, Miranker AD. A peptidomimetic approach to targeting pre-amyloidogenic states in type II diabetes. Chemistry & Biology. 16: 943-50. PMID 19778722 DOI: 10.1016/J.Chembiol.2009.08.013 |
0.695 |
|
| 2009 |
Pierce SE, Wang J, Jayawickramarajah J, Hamilton AD, Brodbelt JS. Examination of the effect of the annealing cation on higher order structures containing guanine or isoguanine repeats. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 11244-55. PMID 19746468 DOI: 10.1002/Chem.200901047 |
0.52 |
|
| 2009 |
Margulies D, Opatowsky Y, Fletcher S, Saraogi I, Tsou LK, Saha S, Lax I, Schlessinger J, Hamilton AD. Surface binding inhibitors of the SCF-KIT protein-protein interaction. Chembiochem : a European Journal of Chemical Biology. 10: 1955-8. PMID 19637142 DOI: 10.1002/Cbic.200900079 |
0.788 |
|
| 2009 |
Saraogi I, Hamilton AD. Recent advances in the development of aryl-based foldamers. Chemical Society Reviews. 38: 1726-43. PMID 19587965 DOI: 10.1039/B819597H |
0.695 |
|
| 2009 |
Margulies D, Hamilton AD. Digital analysis of protein properties by an ensemble of DNA quadruplexes. Journal of the American Chemical Society. 131: 9142-3. PMID 19566086 DOI: 10.1021/Ja900848T |
0.307 |
|
| 2009 |
Rodriguez JM, Ross NT, Katt WP, Dhar D, Lee GI, Hamilton AD. Structure and function of benzoylurea-derived alpha-helix mimetics targeting the Bcl-x(L)/Bak binding interface. Chemmedchem. 4: 649-56. PMID 19330783 DOI: 10.1002/Cmdc.200800387 |
0.778 |
|
| 2009 |
Wyrembak PN, Hamilton AD. Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended beta-strand mimetics. Journal of the American Chemical Society. 131: 4566-7. PMID 19284758 DOI: 10.1021/Ja809245T |
0.784 |
|
| 2009 |
Rosenzweig BA, Hamilton AD. Self-assembly of a four-helix bundle on a DNA quadruplex. Angewandte Chemie (International Ed. in English). 48: 2749-51. PMID 19267377 DOI: 10.1002/Anie.200804849 |
0.663 |
|
| 2009 |
Rodriguez JM, Nevola L, Ross NT, Lee GI, Hamilton AD. Synthetic inhibitors of extended helix-protein interactions based on a biphenyl 4,4'-dicarboxamide scaffold. Chembiochem : a European Journal of Chemical Biology. 10: 829-33. PMID 19263447 DOI: 10.1002/Cbic.200800715 |
0.642 |
|
| 2009 |
Hast MA, Fletcher S, Cummings CG, Pusateri EE, Blaskovich MA, Rivas K, Gelb MH, Van Voorhis WC, Sebti SM, Hamilton AD, Beese LS. Structural basis for binding and selectivity of antimalarial and anticancer ethylenediamine inhibitors to protein farnesyltransferase. Chemistry & Biology. 16: 181-92. PMID 19246009 DOI: 10.1016/J.Chembiol.2009.01.014 |
0.797 |
|
| 2009 |
Rosenzweig BA, Ross NT, Tagore DM, Jayawickramarajah J, Saraogi I, Hamilton AD. Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold. Journal of the American Chemical Society. 131: 5020-1. PMID 19226172 DOI: 10.1021/Ja809219P |
0.793 |
|
| 2009 |
Kazi A, Carie A, Blaskovich MA, Bucher C, Thai V, Moulder S, Peng H, Carrico D, Pusateri E, Pledger WJ, Berndt N, Hamilton A, Sebti SM. Blockade of protein geranylgeranylation inhibits Cdk2-dependent p27Kip1 phosphorylation on Thr187 and accumulates p27Kip1 in the nucleus: implications for breast cancer therapy. Molecular and Cellular Biology. 29: 2254-63. PMID 19204084 DOI: 10.1128/Mcb.01029-08 |
0.763 |
|
| 2009 |
Kayser-Bricker KJ, Glenn MP, Lee SH, Sebti SM, Cheng JQ, Hamilton AD. Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents. Bioorganic & Medicinal Chemistry. 17: 1764-71. PMID 19179081 DOI: 10.1016/J.Bmc.2008.09.058 |
0.333 |
|
| 2009 |
Margulies D, Hamilton AD. Protein recognition by an ensemble of fluorescent DNA G-quadruplexes. Angewandte Chemie (International Ed. in English). 48: 1771-4. PMID 19173368 DOI: 10.1002/Anie.200804887 |
0.303 |
|
| 2009 |
Cai J, Shapiro EM, Hamilton AD. Self-assembling DNA quadruplex conjugated to MRI contrast agents. Bioconjugate Chemistry. 20: 205-8. PMID 19125646 DOI: 10.1021/Bc8004182 |
0.415 |
|
| 2009 |
Cai J, Rosenzweig BA, Hamilton AD. Inhibition of chymotrypsin by a self-assembled DNA quadruplex functionalized with cyclic peptide binding fragments. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 328-32. PMID 19053105 DOI: 10.1002/Chem.200801637 |
0.69 |
|
| 2009 |
Cummings CG, Ross NT, Katt WP, Hamilton AD. Synthesis and biological evaluation of a 5-6-5 imidazole-phenyl-thiazole based alpha-helix mimetic. Organic Letters. 11: 25-8. PMID 19035840 DOI: 10.1021/Ol8022962 |
0.802 |
|
| 2009 |
Siddiquee KAZ, Gunning PT, Glenn M, Katt WP, Zhang S, Schrock C, Sebti SM, Jove R, Hamilton AD, Turkson J. An oxazole-based small-molecule stat3 inhibitor modulates stat3 stability and processing and induces antitumor cell effects (ACS Chemical Biology (2007) 2, (787-798)) Acs Chemical Biology. 4: 309. DOI: 10.1021/Cb9000684 |
0.68 |
|
| 2008 |
Saraogi I, Hamilton AD. alpha-Helix mimetics as inhibitors of protein-protein interactions. Biochemical Society Transactions. 36: 1414-7. PMID 19021566 DOI: 10.1042/Bst0361414 |
0.73 |
|
| 2008 |
Gunning PT, Glenn MP, Siddiquee KA, Katt WP, Masson E, Sebti SM, Turkson J, Hamilton AD. Targeting protein-protein interactions: suppression of Stat3 dimerization with rationally designed small-molecule, nonpeptidic SH2 domain binders. Chembiochem : a European Journal of Chemical Biology. 9: 2800-3. PMID 19006150 DOI: 10.1002/Cbic.200800291 |
0.705 |
|
| 2008 |
Saraogi I, Incarvito CD, Hamilton AD. Controlling curvature in a family of oligoamide alpha-helix mimetics. Angewandte Chemie (International Ed. in English). 47: 9691-4. PMID 18989875 DOI: 10.1002/Anie.200803778 |
0.664 |
|
| 2008 |
Fletcher S, Cummings CG, Rivas K, Katt WP, Hornéy C, Buckner FS, Chakrabarti D, Sebti SM, Gelb MH, Van Voorhis WC, Hamilton AD. Potent, Plasmodium-selective farnesyltransferase inhibitors that arrest the growth of malaria parasites: structure-activity relationships of ethylenediamine-analogue scaffolds and homology model validation. Journal of Medicinal Chemistry. 51: 5176-97. PMID 18686940 DOI: 10.1021/Jm800113P |
0.794 |
|
| 2008 |
Gustafsdottir SM, Wennström S, Fredriksson S, Schallmeiner E, Hamilton AD, Sebti SM, Landegren U. Use of proximity ligation to screen for inhibitors of interactions between vascular endothelial growth factor A and its receptors. Clinical Chemistry. 54: 1218-25. PMID 18499900 DOI: 10.1373/Clinchem.2007.099424 |
0.318 |
|
| 2007 |
Siddiquee KA, Gunning PT, Glenn M, Katt WP, Zhang S, Schrock C, Schroeck C, Sebti SM, Jove R, Hamilton AD, Turkson J. An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. Acs Chemical Biology. 2: 787-98. PMID 18154266 DOI: 10.1021/Cb7001973 |
0.679 |
|
| 2007 |
Rodriguez JM, Hamilton AD. Benzoylurea oligomers: synthetic foldamers that mimic extended alpha helices. Angewandte Chemie (International Ed. in English). 46: 8614-7. PMID 17918270 DOI: 10.1002/Anie.200701869 |
0.581 |
|
| 2007 |
Falsetti SC, Wang DA, Peng H, Carrico D, Cox AD, Der CJ, Hamilton AD, Sebti SM. Geranylgeranyltransferase I inhibitors target RalB to inhibit anchorage-dependent growth and induce apoptosis and RalA to inhibit anchorage-independent growth. Molecular and Cellular Biology. 27: 8003-14. PMID 17875936 DOI: 10.1128/Mcb.00057-07 |
0.729 |
|
| 2007 |
Jayawickramarajah J, Tagore DM, Tsou LK, Hamilton AD. Allosteric control of self-assembly: modulating the formation of guanine quadruplexes through orthogonal aromatic interactions. Angewandte Chemie (International Ed. in English). 46: 7583-6. PMID 17823899 DOI: 10.1002/Anie.200701883 |
0.731 |
|
| 2007 |
Fletcher S, Hamilton AD. Protein-protein interaction inhibitors: small molecules from screening techniques. Current Topics in Medicinal Chemistry. 7: 922-7. PMID 17508923 DOI: 10.2174/156802607780906735 |
0.337 |
|
| 2007 |
Becerril J, Hamilton AD. Helix mimetics as inhibitors of the interaction of the estrogen receptor with coactivator peptides. Angewandte Chemie (International Ed. in English). 46: 4471-3. PMID 17487924 DOI: 10.1002/Anie.200700657 |
0.633 |
|
| 2007 |
Gunning PT, Katt WP, Glenn M, Siddiquee K, Siddique K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: structural recognition of STAT SH2 domains. Bioorganic & Medicinal Chemistry Letters. 17: 1875-8. PMID 17336521 DOI: 10.1016/J.Bmcl.2007.01.077 |
0.686 |
|
| 2007 |
Kayser KJ, Glenn MP, Sebti SM, Cheng JQ, Hamilton AD. Modifications of the GSK3beta substrate sequence to produce substrate-mimetic inhibitors of Akt as potential anti-cancer therapeutics. Bioorganic & Medicinal Chemistry Letters. 17: 2068-73. PMID 17276059 DOI: 10.1016/J.Bmcl.2007.01.004 |
0.742 |
|
| 2007 |
Stern E, Klemic JF, Routenberg DA, Wyrembak PN, Turner-Evans DB, Hamilton AD, LaVan DA, Fahmy TM, Reed MA. Label-free immunodetection with CMOS-compatible semiconducting nanowires. Nature. 445: 519-22. PMID 17268465 DOI: 10.1038/Nature05498 |
0.765 |
|
| 2007 |
Davis JM, Tsou LK, Hamilton AD. Synthetic non-peptide mimetics of alpha-helices. Chemical Society Reviews. 36: 326-34. PMID 17264933 DOI: 10.1039/B608043J |
0.773 |
|
| 2007 |
Wilson AJ, Hong J, Fletcher S, Hamilton AD. Recognition of solvent exposed protein surfaces using anthracene derived receptors. Organic & Biomolecular Chemistry. 5: 276-85. PMID 17205171 DOI: 10.1039/B612975G |
0.507 |
|
| 2007 |
Tagore DM, Sprinz KI, Fletcher S, Jayawickramarajah J, Hamilton AD. Protein recognition and denaturation by self-assembling fragments on a DNA quadruplex scaffold. Angewandte Chemie (International Ed. in English). 46: 223-5. PMID 17136788 DOI: 10.1002/Anie.200603479 |
0.775 |
|
| 2007 |
Tagore DM, Sprinz KI, Hamilton AD. Duplex DNA as a self-assembling template for the identification of bidentate protein-binding agents Supramolecular Chemistry. 19: 129-136. DOI: 10.1080/10610270600990253 |
0.785 |
|
| 2007 |
Park KK, Tsou LK, Hamilton AD. Facile and Selective Aerobic Oxidation of Arylalkanes to Aryl Ketones Using Cesium Carbonate. Cheminform. 38. DOI: 10.1055/S-2006-950189 |
0.655 |
|
| 2007 |
Fletcher S, Hamilton AD. Denaturation and accelerated proteolysis of sizeable heme proteins by synthetic metalloporphyrins New Journal of Chemistry. 31: 623-627. DOI: 10.1039/B700123A |
0.32 |
|
| 2007 |
Gunning PT, Katt WP, Glenn M, Siddiquee K, Kim JS, Jove R, Sebti SM, Turkson J, Hamilton AD. Corrigendum to "Isoform selective inhibition of STAT1 or STAT3 homo-dimerization via peptidomimetic probes: Structural recognition of STAT SH2 domains" [Bioorg. Med. Chem. Lett. 17 (2007) 1875-1878] (DOI:10.1016/j.bmcl.2007.01.077) Bioorganic and Medicinal Chemistry Letters. 17: 2949. DOI: 10.1016/J.Bmcl.2007.03.063 |
0.675 |
|
| 2007 |
Davis JM, Tsou LK, Hamilton AD. Synthetic Non-Peptide Mimetics of α-Helices Cheminform. 38. DOI: 10.1002/chin.200721227 |
0.72 |
|
| 2007 |
Becerril J, Rodriguez JM, Saraogi I, Hamilton AD. Foldamer-based Molecular Recognition Foldamers: Structure, Properties, and Applications. 193-228. DOI: 10.1002/9783527611478.ch7 |
0.744 |
|
| 2006 |
Glenn MP, Chang SY, Hornéy C, Rivas K, Yokoyama K, Pusateri EE, Fletcher S, Cummings CG, Buckner FS, Pendyala PR, Chakrabarti D, Sebti SM, Gelb M, Van Voorhis WC, Hamilton AD. Structurally simple, potent, Plasmodium selective farnesyltransferase inhibitors that arrest the growth of malaria parasites. Journal of Medicinal Chemistry. 49: 5710-27. PMID 16970397 DOI: 10.1021/Jm060081V |
0.782 |
|
| 2006 |
Fletcher S, Hamilton AD. Targeting protein-protein interactions by rational design: mimicry of protein surfaces. Journal of the Royal Society, Interface / the Royal Society. 3: 215-33. PMID 16849232 DOI: 10.1098/Rsif.2006.0115 |
0.333 |
|
| 2006 |
Zhou H, Wang DA, Baldini L, Ennis E, Jain R, Carie A, Sebti SM, Hamilton AD. Structure-activity studies on a library of potent calix[4]arene-based PDGF antagonists that inhibit PDGF-stimulated PDGFR tyrosine phosphorylation. Organic & Biomolecular Chemistry. 4: 2376-86. PMID 16763682 DOI: 10.1039/B515483A |
0.561 |
|
| 2006 |
Peng H, Carrico D, Thai V, Blaskovich M, Bucher C, Pusateri EE, Sebti SM, Hamilton AD. Synthesis and evaluation of potent, highly-selective, 3-aryl-piperazinone inhibitors of protein geranylgeranyltransferase-I. Organic & Biomolecular Chemistry. 4: 1768-84. PMID 16633570 DOI: 10.1039/B517572K |
0.788 |
|
| 2006 |
Kim IC, Hamilton AD. Diphenylindane-based proteomimetics reproduce the projection of the i, i+3, i+4, and i+7 residues on an alpha-helix. Organic Letters. 8: 1751-4. PMID 16623542 DOI: 10.1021/Ol052956Q |
0.325 |
|
| 2006 |
Zhou H, Baldini L, Hong J, Wilson AJ, Hamilton AD. Pattern recognition of proteins based on an array of functionalized porphyrins. Journal of the American Chemical Society. 128: 2421-5. PMID 16478197 DOI: 10.1021/Ja056833C |
0.467 |
|
| 2006 |
Ohkanda J, Strickland CL, Blaskovich MA, Carrico D, Lockman JW, Vogt A, Bucher CJ, Sun J, Qian Y, Knowles D, Pusateri EE, Sebti SM, Hamilton AD. Structure-based design of imidazole-containing peptidomimetic inhibitors of protein farnesyltransferase. Organic & Biomolecular Chemistry. 4: 482-92. PMID 16446806 DOI: 10.1039/B508184J |
0.789 |
|
| 2006 |
Park KK, Tsou LK, Hamilton AD. Facile and selective aerobic oxidation of arylalkanes to aryl ketones using cesium carbonate Synthesis. 3617-3620. DOI: 10.1055/s-2006-950189 |
0.62 |
|
| 2006 |
Rodriguez JM, Hamilton AD. Intramolecular hydrogen bonding allows simple enaminones to structurally mimic the i, i+4, and i+7 residues of an α-helix Tetrahedron Letters. 47: 7443-7446. DOI: 10.1016/J.Tetlet.2006.08.048 |
0.606 |
|
| 2006 |
Estroff LA, Hamilton AD. Cryo-tem, X-ray diffraction and modeling of an organic hydrogel Molecular Gels: Materials With Self-Assembled Fibrillar Networks. 721-742. DOI: 10.1007/1-4020-3689-2_21 |
0.51 |
|
| 2005 |
Guida WC, Hamilton AD, Crotty JW, Sebti SM. Protein farnesyltransferase: flexible docking studies on inhibitors using computational modeling. Journal of Computer-Aided Molecular Design. 19: 871-85. PMID 16607571 DOI: 10.1007/S10822-005-9030-2 |
0.351 |
|
| 2005 |
Davis JM, Truong A, Hamilton AD. Synthesis of a 2,3';6',3''-terpyridine scaffold as an alpha-helix mimetic. Organic Letters. 7: 5405-8. PMID 16288517 DOI: 10.1021/Ol0521228 |
0.532 |
|
| 2005 |
Fletcher S, Hamilton AD. Protein surface recognition and proteomimetics: mimics of protein surface structure and function. Current Opinion in Chemical Biology. 9: 632-8. PMID 16242379 DOI: 10.1016/J.Cbpa.2005.10.006 |
0.353 |
|
| 2005 |
Fan X, Potluri VK, McLeod MC, Wang Y, Liu J, Enick RM, Hamilton AD, Roberts CB, Johnson JK, Beckman EJ. Oxygenated hydrocarbon ionic surfactants exhibit CO2 solubility. Journal of the American Chemical Society. 127: 11754-62. PMID 16104753 DOI: 10.1021/Ja052037V |
0.746 |
|
| 2005 |
Yin H, Lee GI, Sedey KA, Kutzki O, Park HS, Orner BP, Ernst JT, Wang HG, Sebti SM, Hamilton AD. Terphenyl-Based Bak BH3 alpha-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL. Journal of the American Chemical Society. 127: 10191-6. PMID 16028929 DOI: 10.1021/Ja050122X |
0.793 |
|
| 2005 |
Glenn MP, Chang SY, Hucke O, Verlinde CL, Rivas K, Hornéy C, Yokoyama K, Buckner FS, Pendyala PR, Chakrabarti D, Gelb M, Van Voorhis WC, Sebti SM, Hamilton AD. Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites. Angewandte Chemie (International Ed. in English). 44: 4903-6. PMID 16007716 DOI: 10.1002/Anie.200500674 |
0.739 |
|
| 2005 |
Sprinz KI, Tagore DM, Hamilton AD. Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments. Bioorganic & Medicinal Chemistry Letters. 15: 3908-11. PMID 15993069 DOI: 10.1016/J.Bmcl.2005.05.094 |
0.783 |
|
| 2005 |
Chen L, Yin H, Farooqi B, Sebti S, Hamilton AD, Chen J. p53 alpha-Helix mimetics antagonize p53/MDM2 interaction and activate p53. Molecular Cancer Therapeutics. 4: 1019-25. PMID 15956260 DOI: 10.1158/1535-7163.Mct-04-0342 |
0.54 |
|
| 2005 |
Yin H, Hamilton AD. Strategies for targeting protein-protein interactions with synthetic agents. Angewandte Chemie (International Ed. in English). 44: 4130-63. PMID 15954154 DOI: 10.1002/Anie.200461786 |
0.575 |
|
| 2005 |
Sun J, Wang DA, Jain RK, Carie A, Paquette S, Ennis E, Blaskovich MA, Baldini L, Coppola D, Hamilton AD, Sebti SM. Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene. 24: 4701-9. PMID 15897913 DOI: 10.1038/Sj.Onc.1208391 |
0.545 |
|
| 2005 |
Yin H, Lee GI, Sedey KA, Rodriguez JM, Wang HG, Sebti SM, Hamilton AD. Terephthalamide derivatives as mimetics of helical peptides: disruption of the Bcl-x(L)/Bak interaction. Journal of the American Chemical Society. 127: 5463-8. PMID 15826183 DOI: 10.1021/Ja0446404 |
0.703 |
|
| 2005 |
Yin H, Lee GI, Park HS, Payne GA, Rodriguez JM, Sebti SM, Hamilton AD. Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction. Angewandte Chemie (International Ed. in English). 44: 2704-7. PMID 15765497 DOI: 10.1002/Anie.200462316 |
0.68 |
|
| 2005 |
Carrico D, Blaskovich MA, Bucher CJ, Sebti SM, Hamilton AD. Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I. Bioorganic & Medicinal Chemistry. 13: 677-88. PMID 15653335 DOI: 10.1016/J.Bmc.2004.10.053 |
0.751 |
|
| 2005 |
Magliery TJ, Wilson CG, Pan W, Mishler D, Ghosh I, Hamilton AD, Regan L. Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism. Journal of the American Chemical Society. 127: 146-57. PMID 15631464 DOI: 10.1021/Ja046699G |
0.63 |
|
| 2005 |
Woo JT, Nakagawa H, Krecic AM, Nagai K, Hamilton AD, Sebti SM, Stern PH. Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha). Biochemical Pharmacology. 69: 87-95. PMID 15588717 DOI: 10.1016/J.Bcp.2004.08.036 |
0.325 |
|
| 2005 |
Jain RK, Tsou LK, Hamilton AD. Recognition of cytochrome C by tetraphenylporphyrin-based protein surface receptors Macrocyclic Chemistry: Current Trends and Future Perspectives. 267-275. DOI: 10.1007/1-4020-3687-6_17 |
0.725 |
|
| 2005 |
Yin H, Hamilton AD. Strategien zur Modulation von Protein-Protein-Wechselwirkungen mit synthetischen Substanzen Angewandte Chemie. 117: 4200-4235. DOI: 10.1002/Ange.200461786 |
0.536 |
|
| 2005 |
Hamilton AD, Tagore DM, Sprinz KI. Formation and Recognition Properties of Dynamic Combinatorial Libraries Functional Synthetic Receptors. 299-332. DOI: 10.1002/352760572X.ch6 |
0.763 |
|
| 2004 |
Carrico D, Ohkanda J, Kendrick H, Yokoyama K, Blaskovich MA, Bucher CJ, Buckner FS, Van Voorhis WC, Chakrabarti D, Croft SL, Gelb MH, Sebti SM, Hamilton AD. In vitro and in vivo antimalarial activity of peptidomimetic protein farnesyltransferase inhibitors with improved membrane permeability. Bioorganic & Medicinal Chemistry. 12: 6517-26. PMID 15556768 DOI: 10.1016/J.Bmc.2004.09.020 |
0.741 |
|
| 2004 |
Groves K, Wilson AJ, Hamilton AD. Catalytic unfolding and proteolysis of cytochrome C induced by synthetic binding agents. Journal of the American Chemical Society. 126: 12833-42. PMID 15469279 DOI: 10.1021/Ja0317731 |
0.496 |
|
| 2004 |
Jain R, Ernst JT, Kutzki O, Park HS, Hamilton AD. Protein recognition using synthetic surface-targeted agents. Molecular Diversity. 8: 89-100. PMID 15209160 DOI: 10.1023/B:Modi.0000025652.55320.16 |
0.795 |
|
| 2004 |
Sun J, Blaskovich MA, Jain RK, Delarue F, Paris D, Brem S, Wotoczek-Obadia M, Lin Q, Coppola D, Choi K, Mullan M, Hamilton AD, Sebti SM. Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor. Cancer Research. 64: 3586-92. PMID 15150116 DOI: 10.1158/0008-5472.Can-03-2673 |
0.731 |
|
| 2004 |
Baldini L, Wilson AJ, Hong J, Hamilton AD. Pattern-based detection of different proteins using an array of fluorescent protein surface receptors. Journal of the American Chemical Society. 126: 5656-7. PMID 15125644 DOI: 10.1021/Ja039562J |
0.484 |
|
| 2004 |
Estroff LA, Hamilton AD. Water gelation by small organic molecules. Chemical Reviews. 104: 1201-18. PMID 15008620 DOI: 10.1021/Cr0302049 |
0.569 |
|
| 2004 |
Yin H, Hamilton AD. Terephthalamide derivatives as mimetics of the helical region of Bak peptide target Bcl-xL protein. Bioorganic & Medicinal Chemistry Letters. 14: 1375-9. PMID 15006365 DOI: 10.1016/J.Bmcl.2003.09.096 |
0.564 |
|
| 2004 |
Estroff LA, Addadi L, Weiner S, Hamilton AD. An organic hydrogel as a matrix for the growth of calcite crystals. Organic & Biomolecular Chemistry. 2: 137-41. PMID 14737673 DOI: 10.1039/B309731E |
0.569 |
|
| 2004 |
Ohkanda J, Buckner FS, Lockman JW, Yokoyama K, Carrico D, Eastman R, de Luca-Fradley K, Davies W, Croft SL, Van Voorhis WC, Gelb MH, Sebti SM, Hamilton AD. Design and synthesis of peptidomimetic protein farnesyltransferase inhibitors as anti-Trypanosoma brucei agents. Journal of Medicinal Chemistry. 47: 432-45. PMID 14711313 DOI: 10.1021/Jm030236O |
0.752 |
|
| 2004 |
Estroff LA, Incarvito CD, Hamilton AD. Design of a synthetic foldamer that modifies the growth of calcite crystals. Journal of the American Chemical Society. 126: 2-3. PMID 14709030 DOI: 10.1021/Ja037614Z |
0.602 |
|
| 2004 |
Tsou LK, Jain RK, Hamilton AD. Protein surface recognition by porphyrin-based receptors Journal of Porphyrins and Phthalocyanines. 8: 141-147. DOI: 10.1142/S1088424604000131 |
0.765 |
|
| 2003 |
Estroff LA, Huang JS, Hamilton AD. Fiber formation in water by a mono-urea dicarboxylic acid. Chemical Communications (Cambridge, England). 2958-9. PMID 14703806 DOI: 10.1039/B306351H |
0.569 |
|
| 2003 |
Choi K, Hamilton AD. Rigid macrocyclic triamides as anion receptors: anion-dependent binding stoichiometries and 1H chemical shift changes. Journal of the American Chemical Society. 125: 10241-9. PMID 12926947 DOI: 10.1021/Ja034563X |
0.552 |
|
| 2003 |
Wilson AJ, Groves K, Jain RK, Park HS, Hamilton AD. Directed denaturation: room temperature and stoichiometric unfolding of cytochrome C by a metalloporphyrin dimer. Journal of the American Chemical Society. 125: 4420-1. PMID 12683802 DOI: 10.1021/Ja028574M |
0.604 |
|
| 2003 |
Ernst JT, Becerril J, Park HS, Yin H, Hamilton AD. Design and application of an alpha-helix-mimetic scaffold based on an oligoamide-foldamer strategy: antagonism of the Bak BH3/Bcl-xL complex. Angewandte Chemie (International Ed. in English). 42: 535-9. PMID 12569483 DOI: 10.1002/Anie.200390154 |
0.775 |
|
| 2003 |
Sachpatzidis A, Benton BK, Manfredi JP, Wang H, Hamilton A, Dohlman HG, Lolis E. Identification of allosteric peptide agonists of CXCR4. The Journal of Biological Chemistry. 278: 896-907. PMID 12417595 DOI: 10.1074/Jbc.M204667200 |
0.302 |
|
| 2003 |
Potluri VK, Hamilton AD, Karanikas CF, Bane SE, Xu J, Beckman EJ, Enick RM. The high CO2-solubility of per-acetylated α-, β-, and γ-cyclodextrin Fluid Phase Equilibria. 211: 211-217. DOI: 10.1016/S0378-3812(03)00206-1 |
0.742 |
|
| 2003 |
Choi K, Hamilton AD. Macrocyclic anion receptors based on directed hydrogen bonding interactions Coordination Chemistry Reviews. 240: 101-110. DOI: 10.1016/S0010-8545(02)00305-3 |
0.553 |
|
| 2003 |
Estroff LA, Leiserowitz L, Addadi L, Weiner S, Hamilton AD. Characterization of an organic hydrogel: A cryo-transmission electron microscopy and X-ray diffraction study Advanced Materials. 15: 38-42. DOI: 10.1002/Adma.200390004 |
0.554 |
|
| 2002 |
Orner BP, Salvatella X, Sánchez Quesada J, De Mendoza J, Giralt E, Hamilton AD. De novo protein surface design: use of cation-pi interactions to enhance binding between an alpha-helical peptide and a cationic molecule in 50 % aqueous solution. Angewandte Chemie (International Ed. in English). 41: 117-9. PMID 12491457 DOI: 10.1002/1521-3773(20020104)41:1<117::Aid-Anie117>3.0.Co;2-J |
0.72 |
|
| 2002 |
Ernst JT, Kutzki O, Debnath AK, Jiang S, Lu H, Hamilton AD. Design of a protein surface antagonist based on alpha-helix mimicry: inhibition of gp41 assembly and viral fusion. Angewandte Chemie (International Ed. in English). 41: 278-81. PMID 12491408 DOI: 10.1002/1521-3773(20020118)41:2<278::Aid-Anie278>3.0.Co;2-A |
0.757 |
|
| 2002 |
Zhao Q, Ernst JT, Hamilton AD, Debnath AK, Jiang S. XTT formazan widely used to detect cell viability inhibits HIV type 1 infection in vitro by targeting gp41. Aids Research and Human Retroviruses. 18: 989-97. PMID 12396451 DOI: 10.1089/08892220260235353 |
0.738 |
|
| 2002 |
Kutzki O, Park HS, Ernst JT, Orner BP, Yin H, Hamilton AD. Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry. Journal of the American Chemical Society. 124: 11838-9. PMID 12358513 DOI: 10.1021/Ja026861K |
0.804 |
|
| 2002 |
Potluri VK, Xu J, Enick R, Beckman E, Hamilton AD. Peracetylated sugar derivatives show high solubility in liquid and supercritical carbon dioxide. Organic Letters. 4: 2333-5. PMID 12098240 DOI: 10.1021/Ol026007Y |
0.74 |
|
| 2002 |
Crespo NC, Delarue F, Ohkanda J, Carrico D, Hamilton AD, Sebti SM. The farnesyltransferase inhibitor, FTI-2153, inhibits bipolar spindle formation during mitosis independently of transformation and Ras and p53 mutation status. Cell Death and Differentiation. 9: 702-9. PMID 12058275 DOI: 10.1038/Sj.Cdd.4401023 |
0.71 |
|
| 2002 |
Wang G, Hamilton AD. Synthesis and self-assembling properties of polymerizable organogelators. Chemistry (Weinheim An Der Bergstrasse, Germany). 8: 1954-61. PMID 12007106 DOI: 10.1002/1521-3765(20020415)8:8<1954::Aid-Chem1954>3.0.Co;2-X |
0.304 |
|
| 2002 |
Park HS, Lin Q, Hamilton AD. Modulation of protein-protein interactions by synthetic receptors: design of molecules that disrupt serine protease-proteinaceous inhibitor interaction. Proceedings of the National Academy of Sciences of the United States of America. 99: 5105-9. PMID 11959960 DOI: 10.1073/Pnas.082675899 |
0.599 |
|
| 2002 |
Ohkanda J, Knowles DB, Blaskovich MA, Sebti SM, Hamilton AD. Inhibitors of protein farnesyltransferase as novel anticancer agents. Current Topics in Medicinal Chemistry. 2: 303-23. PMID 11944822 DOI: 10.2174/1568026023394281 |
0.761 |
|
| 2002 |
Li X, Liu L, Tupper JC, Bannerman DD, Winn RK, Sebti SM, Hamilton AD, Harlan JM. Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells. The Journal of Biological Chemistry. 277: 15309-16. PMID 11839765 DOI: 10.1074/Jbc.M201253200 |
0.305 |
|
| 2002 |
Ohkanda J, Lockman JW, Kothare MA, Qian Y, Blaskovich MA, Sebti SM, Hamilton AD. Design and synthesis of potent nonpeptidic farnesyltransferase inhibitors based on a terphenyl scaffold. Journal of Medicinal Chemistry. 45: 177-88. PMID 11754590 DOI: 10.1021/Jm0103099 |
0.356 |
|
| 2002 |
Lin Q, Hamilton AD. Design and synthesis of multiple-loop receptors based on a calix〚4〛arene scaffold for protein surface recognition Comptes Rendus Chimie. 5: 441-450. DOI: 10.1016/S1631-0748(02)01408-X |
0.392 |
|
| 2002 |
Potluri VK, Hamilton AD. Isophthalic acid-Derived organogelators Journal of Supramolecular Chemistry. 2: 321-326. DOI: 10.1016/S1472-7862(03)00088-1 |
0.754 |
|
| 2002 |
Zafar A, Melendez R, Geib SJ, Hamilton AD. Hydrogen bond controlled aggregation of guanidinium-carboxylate derivatives in the solid state Tetrahedron. 58: 683-690. DOI: 10.1016/S0040-4020(01)01106-1 |
0.305 |
|
| 2002 |
Jain RK, Hamilton AD. Designing Protein Denaturants: Synthetic Agents Induce Cytochromec Unfolding at Low Concentrations and Stoichiometries Angewandte Chemie International Edition. 41: 641-643. DOI: 10.1002/1521-3773(20020215)41:4<641::Aid-Anie641>3.0.Co;2-1 |
0.544 |
|
| 2001 |
Choi K, Hamilton AD. A Dual Channel Fluorescence Chemosensor for Anions Involving Intermolecular Excited State Proton Transfer. Angewandte Chemie (International Ed. in English). 40: 3912-3915. PMID 29712141 DOI: 10.1002/1521-3773(20011015)40:20<3912::Aid-Anie3912>3.0.Co;2-R |
0.494 |
|
| 2001 |
Wei Y, McLendon GL, Hamilton AD, Case MA, Purring CB, Lin Q, Park HS, Lee CS, Yu T. Disruption of protein-protein interactions: design of a synthetic receptor that blocks the binding of cytochrome c to cytochrome c peroxidase. Chemical Communications (Cambridge, England). 1580-1. PMID 12240391 DOI: 10.1039/B104142H |
0.684 |
|
| 2001 |
Linton BR, Goodman MS, Fan E, van Arman SA, Hamilton AD. Thermodynamic aspects of dicarboxylate recognition by simple artificial receptors. The Journal of Organic Chemistry. 66: 7313-9. PMID 11681943 DOI: 10.1021/Jo010413Y |
0.785 |
|
| 2001 |
Choi K, Hamilton AD. A Dual Channel Fluorescence Chemosensor for Anions Involving Intermolecular Excited State Proton Transfer We thank the National Institutes of Health for financial support of this work. Angewandte Chemie (International Ed. in English). 40: 3912-3915. PMID 11668574 DOI: 10.1002/1521-3773(20011015)40:20<3912::AID-ANIE3912>3.0.CO;2-R |
0.406 |
|
| 2001 |
Turkson J, Ryan D, Kim JS, Zhang Y, Chen Z, Haura E, Laudano A, Sebti S, Hamilton AD, Jove R. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. The Journal of Biological Chemistry. 276: 45443-55. PMID 11579100 DOI: 10.1074/Jbc.M107527200 |
0.31 |
|
| 2001 |
Hamuro Y, Hamilton AD. Functionalized oligoanthranilamides: modular and conformationally controlled scaffolds. Bioorganic & Medicinal Chemistry. 9: 2355-63. PMID 11553476 DOI: 10.1016/S0968-0896(01)00161-4 |
0.319 |
|
| 2001 |
Orner BP, Ernst JT, Hamilton AD. Toward proteomimetics: terphenyl derivatives as structural and functional mimics of extended regions of an alpha-helix. Journal of the American Chemical Society. 123: 5382-3. PMID 11457415 DOI: 10.1021/Ja0025548 |
0.769 |
|
| 2001 |
Choi K, Hamilton AD. Selective anion binding by a macrocycle with convergent hydrogen bonding functionality. Journal of the American Chemical Society. 123: 2456-7. PMID 11456908 DOI: 10.1021/Ja005772+ |
0.526 |
|
| 2001 |
Ohkanda J, Lockman JW, Yokoyama K, Gelb MH, Croft SL, Kendrick H, Harrell MI, Feagin JE, Blaskovich MA, Sebti SM, Hamilton AD. Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activity. Bioorganic & Medicinal Chemistry Letters. 11: 761-4. PMID 11277514 DOI: 10.1016/S0960-894X(01)00055-5 |
0.318 |
|
| 2001 |
Sun J, Nam S, Lee CS, Li B, Coppola D, Hamilton AD, Dou QP, Sebti SM. CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice. Cancer Research. 61: 1280-4. PMID 11245420 |
0.496 |
|
| 2001 |
Orner BP, Hamilton AD. The guanidinium group in molecular recognition: Design and synthetic approaches Journal of Inclusion Phenomena. 41: 141-147. DOI: 10.1023/A:1014433715641 |
0.7 |
|
| 2001 |
Estroff LA, Hamilton AD. At the interface of organic and inorganic chemistry: Bioinspired synthesis of composite materials Chemistry of Materials. 13: 3227-3235. DOI: 10.1021/Cm010110K |
0.572 |
|
| 2001 |
Lee C, Lee K, Hamilton AD. Erratum to “Constrained analogs of methionine: asymmetric synthesis of χ-angle restricted methionine derivatives through [3.1.0]-γ-lactone cyclopropane ring opening” Tetrahedron Letters. 42: 2929. DOI: 10.1016/S0040-4039(01)00307-0 |
0.662 |
|
| 2001 |
Lee C, Lee K, Hamilton AD. Constrained analogs of methionine: asymmetric synthesis of χ-angle restricted methionine derivatives through [3.1.0]-γ-lactone cyclopropane ring opening Tetrahedron Letters. 42: 211-213. DOI: 10.1016/S0040-4039(00)01912-2 |
0.556 |
|
| 2000 |
Peczuh MW, Hamilton AD. Peptide and protein recognition by designed molecules. Chemical Reviews. 100: 2479-94. PMID 11749292 DOI: 10.1021/Cr9900026 |
0.651 |
|
| 2000 |
Sebti SM, Hamilton AD. Design of growth factor antagonists with antiangiogenic and antitumor properties. Oncogene. 19: 6566-73. PMID 11426641 DOI: 10.1038/Sj.Onc.1204121 |
0.332 |
|
| 2000 |
Adnane J, Bizouarn FA, Chen Z, Ohkanda J, Hamilton AD, Munoz-Antonia T, Sebti SM. Inhibition of farnesyltransferase increases TGFbeta type II receptor expression and enhances the responsiveness of human cancer cells to TGFbeta. Oncogene. 19: 5525-33. PMID 11114730 DOI: 10.1038/Sj.Onc.1203920 |
0.314 |
|
| 2000 |
Estroff LA, Hamilton AD. Effective Gelation of Water Using a Series of Bis-urea Dicarboxylic Acids We thank the National Science Foundation (CHE9817240) for financial support of this work and Dr. James Eckert (Department of Geology, Yale University) for assistance with the electron microscopy. We also thank R. E. Meléndez for compound 1. Angewandte Chemie (International Ed. in English). 39: 3447-3450. PMID 11091385 DOI: 10.1002/1521-3773(20001002)39:19<3447::Aid-Anie3447>3.0.Co;2-X |
0.568 |
|
| 2000 |
Sebti SM, Hamilton AD. Inhibition of Rho GTPases using protein geranylgeranyltransferase I inhibitors. Methods in Enzymology. 325: 381-8. PMID 11036620 DOI: 10.1016/S0076-6879(00)25459-1 |
0.335 |
|
| 2000 |
Blaskovich MA, Lin Q, Delarue FL, Sun J, Park HS, Coppola D, Hamilton AD, Sebti SM. Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice. Nature Biotechnology. 18: 1065-70. PMID 11017044 DOI: 10.1038/80257 |
0.459 |
|
| 2000 |
Linton BR, Goodman MS, Hamilton AD. Nitronate anion recognition and modulation of ambident reactivity by hydrogen-bonding receptors. Chemistry (Weinheim An Der Bergstrasse, Germany). 6: 2449-55. PMID 10939746 DOI: 10.1002/1521-3765(20000703)6:13<2449::Aid-Chem2449>3.0.Co;2-9 |
0.733 |
|
| 2000 |
Coxon FP, Helfrich MH, Hof RV, Sebti S, Ralston SH, Hamilton A, Rogers MJ. Protein geranylgeranylation is required for osteoclast formation, function, and survival: inhibition by bisphosphonates and GGTI-298. Journal of Bone and Mineral Research. 15: 1467-1476. PMID 10934645 DOI: 10.1359/Jbmr.2000.15.8.1467 |
0.301 |
|
| 2000 |
Jain RK, Hamilton AD. Protein surface recognition by synthetic receptors based on a tetraphenylporphyrin scaffold. Organic Letters. 2: 1721-3. PMID 10880210 DOI: 10.1021/Ol005871S |
0.547 |
|
| 2000 |
Linton BR, Carr AJ, Orner BP, Hamilton AD. A versatile one-Pot synthesis of 1,3-substituted guanidines from carbamoyl isothiocyanates The Journal of Organic Chemistry. 65: 1566-8. PMID 10814126 DOI: 10.1021/Jo991458Q |
0.771 |
|
| 2000 |
Salvatella X, Peczuh MW, Gairí M, Jain RK, Sánchez-Quesada J, Mendoza Jd, Hamilton AD, Giralt E. Side chain elongation causes a change from enthalpy driven to entropy driven binding in the molecular recognition of tetraanionic peptides Chemical Communications. 1399-1400. DOI: 10.1039/B003728L |
0.722 |
|
| 2000 |
Linton BR, Carr AJ, Orner BP, Hamilton AD. A versatile one-pot synthesis of 1,3-substituted guanidines from carbamoyl isothiocyanates Journal of Organic Chemistry. 65: 1566-1568. DOI: 10.1021/jo991458q |
0.771 |
|
| 2000 |
Kotharé MA, Ohkanda J, Lockman JW, Qian Y, Blaskovich MA, Sebti SM, Hamilton AD. Development of a Tripeptide Mimetic Strategy for the Inhibition of Protein Farnesyltransferase Tetrahedron. 56: 9833-9841. DOI: 10.1016/S0040-4020(00)00890-5 |
0.334 |
|
| 2000 |
Zafar A, Geib SJ, Hamuro Y, Carr AJ, Hamilton AD. Hydrogen Bonding Control of Molecular Self-Assembly: Aggregation Behavior of Acylaminopyridine–Carboxylic Acid Derivatives in Solution and the Solid State Tetrahedron. 56: 8419-8427. DOI: 10.1016/S0040-4020(00)00733-X |
0.302 |
|
| 2000 |
Peczuh MW, Hamilton AD. ChemInform Abstract: Peptide and Protein Recognition by Designed Molecules Cheminform. 31: no-no. DOI: 10.1002/chin.200042260 |
0.621 |
|
| 2000 |
Fan E, Hamilton AD. ChemInform Abstract: Molecular Recognition: Synthetic Approaches to Artificial Receptors Cheminform. 31: no-no. DOI: 10.1002/chin.200041258 |
0.432 |
|
| 1999 |
Qian Y, Marugan JJ, Fossum RD, Vogt A, Sebti SM, Hamilton AD. Probing the hydrophobic pocket of farnesyltransferase: aromatic substitution of CAAX peptidomimetics leads to highly potent inhibitors. Bioorganic & Medicinal Chemistry. 7: 3011-24. PMID 10658608 DOI: 10.1016/S0968-0896(99)00252-7 |
0.33 |
|
| 1999 |
Liu L, Moesner P, Kovach NL, Bailey R, Hamilton AD, Sebti SM, Harlan JM. Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s). The Journal of Biological Chemistry. 274: 33334-40. PMID 10559211 DOI: 10.1074/Jbc.274.47.33334 |
0.327 |
|
| 1999 |
Linton B, Hamilton AD. Host-guest chemistry: combinatorial receptors. Current Opinion in Chemical Biology. 3: 307-312. PMID 10359712 DOI: 10.1016/S1367-5931(99)80047-7 |
0.732 |
|
| 1999 |
Vasudevan A, Qian Y, Vogt A, Blaskovich MA, Ohkanda J, Sebti SM, Hamilton AD. Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I Journal of Medicinal Chemistry. 42: 1333-1340. PMID 10212118 DOI: 10.1021/Jm9900873 |
0.374 |
|
| 1999 |
Weiner WS, Hamilton AD. Synthesis and binding studies of a 1-alkyl-3,6-diamino-4-quinolone based receptor for N-acylated dipeptides. Bioorganic & Medicinal Chemistry Letters. 8: 681-6. PMID 9871582 DOI: 10.1016/S0960-894X(98)00099-7 |
0.33 |
|
| 1999 |
Haack T, Peczuh MW, Salvatella X, Sánchez-Quesada J, de Mendoza J, Hamilton AD, Giralt E. Surface Recognition and Helix Stabilization of a Tetraaspartate Peptide by Shape and Electrostatic Complementarity of an Artificial Receptor Journal of the American Chemical Society. 121: 11813-11820. DOI: 10.1021/Ja9910154 |
0.629 |
|
| 1999 |
Park HS, Lin Q, Hamilton AD. Protein Surface Recognition by Synthetic Receptors: A Route to Novel Submicromolar Inhibitors for α-Chymotrypsin Journal of the American Chemical Society. 121: 8-13. DOI: 10.1021/Ja981504O |
0.375 |
|
| 1999 |
Zimmerman SC, Hamilton AD. Model systems Current Opinion in Chemical Biology. 3: 711-713. DOI: 10.1016/S1367-5931(99)00041-1 |
0.465 |
|
| 1999 |
Linton B, Hamilton AD. Calorimetric investigation of guanidinium-carboxylate interactions Tetrahedron. 55: 6027-6038. DOI: 10.1016/S0040-4020(99)00277-X |
0.739 |
|
| 1998 |
Lin Q, Park HS, Hamuro Y, Lee CS, Hamilton AD. Protein surface recognition by synthetic agents: design and structural requirements of a family of artificial receptors that bind to cytochrome c. Biopolymers. 47: 285-97. PMID 10036970 DOI: 10.1002/(Sici)1097-0282(1998)47:4<285::Aid-Bip4>3.0.Co;2-C |
0.65 |
|
| 1998 |
Stark WW, Blaskovich MA, Johnson BA, Qian Y, Vasudevan A, Pitt B, Hamilton AD, Sebti SM, Davies P. Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells American Journal of Physiology - Lung Cellular and Molecular Physiology. 275. PMID 9688935 DOI: 10.1152/Ajplung.1998.275.1.L55 |
0.315 |
|
| 1998 |
Chen H, Weiner WS, Hamilton AD. Recognition of neutral species with synthetic receptors. Current Opinion in Chemical Biology. 1: 458-66. PMID 9667896 DOI: 10.1016/S1367-5931(97)80039-7 |
0.32 |
|
| 1998 |
Bredel M, Pollack IF, Freund JM, Hamilton AD, Sebti SM. Inhibition of Ras and related G-proteins as a therapeutic strategy for blocking malignant glioma growth Neurosurgery. 43: 124-132. PMID 9657198 DOI: 10.1097/00006123-199807000-00081 |
0.311 |
|
| 1998 |
Qian Y, Vogt A, Vasudevan A, Sebti SM, Hamilton AD. Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics Bioorganic and Medicinal Chemistry. 6: 293-299. PMID 9568283 DOI: 10.1016/S0968-0896(97)10040-2 |
0.332 |
|
| 1998 |
Read I, Linton B, Hamilton AD, Waldeck DH. Experimental Measurements of Low-Frequency Intermolecular Host−Guest Dynamics The Journal of Physical Chemistry B. 102: 5394-5403. DOI: 10.1021/Jp981417I |
0.703 |
|
| 1998 |
Sebti SM, Hamilton AD. New approaches to anticancer drug design based on the inhibition of farnesyltransferase Drug Discovery Today. 3: 26-33. DOI: 10.1016/S1359-6446(97)01122-7 |
0.309 |
|
| 1998 |
Shao Y, Linton B, Hamilton AD, Weber SG. Electrochemical studies on molecular recognition of anions: Complex formation between xylylenyl bis-iminoimidazolinium and dicarboxylates in nitrobenzene and water Journal of Electroanalytical Chemistry. 441: 33-37. DOI: 10.1016/S0022-0728(97)00394-X |
0.728 |
|
| 1997 |
Linton B, Hamilton AD. Formation of Artificial Receptors by Metal-Templated Self-Assembly. Chemical Reviews. 97: 1669-1680. PMID 11851462 DOI: 10.1021/Cr960375W |
0.721 |
|
| 1997 |
Lerner EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti SM. Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines Oncogene. 15: 1283-1288. PMID 9315095 DOI: 10.1038/Sj.Onc.1201296 |
0.726 |
|
| 1997 |
Albert JS, Peczuh MW, Hamilton AD. Design, synthesis and evaluation of synthetic receptors for the recognition of aspartate pairs in an α-helical confirmation Bioorganic and Medicinal Chemistry. 5: 1455-1467. PMID 9313852 DOI: 10.1016/S0968-0896(97)00086-2 |
0.674 |
|
| 1997 |
Qian Y, Sebti SM, Hamilton AD. Farnesyltransferase as a target for anticancer drug design Biopolymers. 43: 25-41. PMID 9174410 DOI: 10.1002/(Sici)1097-0282(1997)43:1<25::Aid-Bip4>3.0.Co;2-2 |
0.309 |
|
| 1997 |
Peczuh MW, Hamilton AD, Sánchez-Quesada J, de Mendoza J, Haack T, Giralt E. Recognition and Stabilization of an α-Helical Peptide by a Synthetic Receptor Journal of the American Chemical Society. 119: 9327-9328. DOI: 10.1021/Ja970951L |
0.635 |
|
| 1997 |
Hamuro Y, Geib SJ, Hamilton AD. Novel Folding Patterns in a Family of Oligoanthranilamides: Non-Peptide Oligomers That Form Extended Helical Secondary Structures Journal of the American Chemical Society. 119: 10587-10593. DOI: 10.1021/Ja963449U |
0.335 |
|
| 1996 |
McGuire TF, Qian Y, Vogt A, Hamilton AD, Sebti SM. Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation Journal of Biological Chemistry. 271: 27402-27407. PMID 8910319 DOI: 10.1074/Jbc.271.44.27402 |
0.315 |
|
| 1996 |
Hopkins RB, Albert JS, Van Engen D, Hamilton AD. Synthesis and structure of chiral macrocycles containing 2,2'-bipyridine subunits Bioorganic and Medicinal Chemistry. 4: 1121-1128. PMID 8831984 DOI: 10.1016/0968-0896(96)00124-1 |
0.336 |
|
| 1996 |
Qian Y, Vogt A, Sebti SM, Hamilton AD. Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors Journal of Medicinal Chemistry. 39: 217-223. PMID 8568811 DOI: 10.1021/Jm950414G |
0.323 |
|
| 1996 |
Hamuro Y, Geib SJ, Hamilton AD. Oligoanthranilamides. Non-Peptide Subunits That Show Formation of Specific Secondary Structure Journal of the American Chemical Society. 118: 7529-7541. DOI: 10.1021/Ja9539857 |
0.317 |
|
| 1996 |
Zafar A, Yang J, Geib SJ, Hamilton AD. Linked bis-isophthalic acid derivatives as bulding blocks in the design of self-assembling structures Tetrahedron Letters. 37: 2327-2330. DOI: 10.1016/0040-4039(96)00287-0 |
0.324 |
|
| 1995 |
Vogt A, Qian Y, Blaskovich MA, Fossum RD, Hamilton AD, Sebti SM. A non-peptide mimetic of Ras-CAAX: Selective inhibition of farnesyltransferase and Ras processing Journal of Biological Chemistry. 270: 660-664. PMID 7822292 DOI: 10.1074/Jbc.270.2.660 |
0.321 |
|
| 1995 |
McGuire TF, Qian Y, Blaskovich MA, Fossum RD, Sun J, Marlowe T, Corey SJ, Wathen SP, Vogt A, Hamilton AD. CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase. Biochemical and Biophysical Research Communications. 214: 295-303. PMID 7669049 DOI: 10.1006/Bbrc.1995.2287 |
0.304 |
|
| 1995 |
Fan E, Yang J, Geib SJ, Stoner TC, Hopkins MD, Hamilton AD. Hydrogen-bonding control of molecular aggregation: Self-complementary subunits lead to rod-shaped structures in the solid state Journal of the Chemical Society, Chemical Communications. 1251-1252. DOI: 10.1039/C39950001251 |
0.517 |
|
| 1995 |
Goodman MS, Jubian V, Linton B, Hamilton AD. A Combinatorial Library Approach to Artificial Receptor Design Journal of the American Chemical Society. 117: 11610-11611. DOI: 10.1021/Ja00151A039 |
0.723 |
|
| 1995 |
Albert JS, Goodman MS, Hamilton AD. Molecular recognition of proteins: Sequence-selective binding of aspartate pairs in helical peptides Journal of the American Chemical Society. 117: 1143-1144. DOI: 10.1021/Ja00108A037 |
0.335 |
|
| 1995 |
Tecilla P, Jubian V, Hamilton AD. Synthetic hydrogen bonding receptors as models of transacylase enzymes Tetrahedron. 51: 435-448. DOI: 10.1016/0040-4020(94)00907-C |
0.303 |
|
| 1995 |
Jubian V, Veronese A, Dixon RP, Hamilton AD. Acceleration of a Phosphate Diester Transesterification Reaction by Bis(alkylguanidinium) Receptors Containing an Appended General Base Angewandte Chemie International Edition in English. 34: 1237-1239. DOI: 10.1002/Anie.199512371 |
0.686 |
|
| 1995 |
Jubian V, Veronese A, Dixon RP, Hamilton AD. Beschleunigung der Umesterung eines Phosphorsäurediesters durch basensubstituierte Bis(alkylguanidinium)-Rezeptoren Angewandte Chemie. 107: 1343-1345. DOI: 10.1002/Ange.19951071120 |
0.681 |
|
| 1994 |
Valenta JN, Dixon RP, Hamilton AD, Weber SG. Enhanced extraction of phenobarbital from serum with a designed artificial receptor. Analytical Chemistry. 66: 2397-403. PMID 8080112 DOI: 10.1021/Ac00086A028 |
0.688 |
|
| 1994 |
Das G, Hamilton AD. Molecular Recognition of Carbohydrates: Strong Binding of Alkyl Glycosides by Phosphonate Derivatives Journal of the American Chemical Society. 116: 11139-11140. DOI: 10.1021/Ja00103A032 |
0.312 |
|
| 1994 |
Fan E, Vicent C, Geib SJ, Hamilton AD. Molecular Recognition in the Solid State: Hydrogen-Bonding Control of Molecular Aggregation Chemistry of Materials. 6: 1113-1117. DOI: 10.1021/Cm00044A009 |
0.495 |
|
| 1994 |
Yang J, Marendaz J, Geib SJ, Hamilton AD. Hydrogen bonding control of self-assembly: Simple isophthalic acid derivatives form cyclic hexameric aggregates Tetrahedron Letters. 35: 3665-3668. DOI: 10.1016/S0040-4039(00)73066-8 |
0.302 |
|
| 1993 |
Hamilton AD, Fan E, Arman SV, Geib SJ, Yang J. The Design of Artificial Receptors for Complexation and Controlled Aggregation Philosophical Transactions of the Royal Society A. 345: 57-66. DOI: 10.1098/Rsta.1993.0117 |
0.304 |
|
| 1993 |
Hamilton AD, Fan E, Arman SV, Vicent C, Tellado FG, Geib SJ. Molecular recognition. Design of new receptors for complexation and catalysis Supramolecular Chemistry. 1: 247-252. DOI: 10.1080/10610279308035167 |
0.551 |
|
| 1993 |
Yang J, Fan E, Geib SJ, Hamilton AD. Hydrogen-bonding control of molecular self-assembly: formation of a 2 + 2 complex in solution and in the solid state Journal of the American Chemical Society. 115: 5314-5315. DOI: 10.1021/Ja00065A061 |
0.497 |
|
| 1993 |
Fan E, Van Arman SA, Kincaid S, Hamilton AD. Molecular recognition: hydrogen-bonding receptors that function in highly competitive solvents Journal of the American Chemical Society. 115: 369-370. DOI: 10.1021/Ja00054A066 |
0.503 |
|
| 1993 |
Geib SJ, Vicent C, Fan E, Hamilton AD. A Self-Assembling, Hydrogen-Bonded Helix Angewandte Chemie International Edition in English. 32: 119-121. DOI: 10.1002/Anie.199301191 |
0.487 |
|
| 1993 |
Geib SJ, Vicent C, Fan E, Hamilton AD. Selbstorganisation zu einer Helix durch Wasserstoffbrückenbindungen Angewandte Chemie. 105: 83-85. DOI: 10.1002/Ange.19931050115 |
0.496 |
|
| 1992 |
Jubian V, Dixon RP, Hamilton AD. Molecular recognition and catalysis. Acceleration of phosphodiester cleavage by a simple hydrogen-bonding receptor Journal of the American Chemical Society. 114: 1120-1121. DOI: 10.1021/Ja00029A068 |
0.7 |
|
| 1992 |
Dixon RP, Geib SJ, Hamilton AD. Molecular recognition: bis-acylguanidiniums provide a simple family of receptors for phosphodiesters Journal of the American Chemical Society. 114: 365-366. DOI: 10.1021/Ja00027A059 |
0.69 |
|
| 1992 |
Vicent C, Fan E, Hamilton AD. Molecular recognition: directed hydrogen bonding receptors for acylamino acid carboxylates Tetrahedron Letters. 33: 4269-4272. DOI: 10.1016/S0040-4039(00)74235-3 |
0.519 |
|
| 1992 |
Hirst SC, Tecilla P, Geib SJ, Fan E, Hamilton AD. Molecular Recognition of Phosphate Esters: A Balance of Hydrogen Bonding and Proton Transfer Interactions Israel Journal of Chemistry. 32: 105-111. DOI: 10.1002/Ijch.199200014 |
0.53 |
|
| 1991 |
Geib SJ, Hirst SC, Vicent C, Hamilton AD. Molecular recognition and the design of solid state structures: protonation-induced conformational change and self-assembly of 2,6-diamidopyridinium phosphates Journal of the Chemical Society, Chemical Communications. 1283-1285. DOI: 10.1039/C39910001283 |
0.311 |
|
| 1991 |
Chang SK, Van Engen D, Fan E, Hamilton AD. Hydrogen bonding and molecular recognition: synthetic, complexation, and structural studies on barbiturate binding to an artificial receptor Journal of the American Chemical Society. 113: 7640-7645. DOI: 10.1021/Ja00020A027 |
0.531 |
|
| 1990 |
Hamilton AD, Little D. Nucleotide base recognition: synthesis of artificial receptors containing two distinct binding regions for the complexation of bis-thymine derivatives Journal of the Chemical Society, Chemical Communications. 297-300. DOI: 10.1039/C39900000297 |
0.312 |
|
| 1990 |
Tecilla P, Dixon RP, Slobodkin G, Alavi DS, Waldeck DH, Hamilton AD. Hydrogen-bonding self-assembly of multichromophore structures Journal of the American Chemical Society. 112: 9408-9410. DOI: 10.1021/Ja00181A061 |
0.709 |
|
| 1990 |
Hamilton AD. Molecular recognition: Design and synthesis of artificial receptors employing directed hydrogen bonding interactions Journal of Chemical Education. 67: 821. DOI: 10.1021/Ed067P821 |
0.311 |
|
| 1990 |
Hirst SC, Hamilton AD. Molecular recognition: Cyclobutane thymine diners as rigid two-site receptors Tetrahedron Letters. 31: 2401-2404. DOI: 10.1016/S0040-4039(00)97372-6 |
0.3 |
|
| 1989 |
Hamilton AD, Muehldorf A, Chang S, Pant N, Goswami S, Engen D. Nucleotide recognition by macrocyclic receptors Journal of Inclusion Phenomena and Molecular Recognition in Chemistry. 7: 27-38. DOI: 10.1007/Bf01112780 |
0.31 |
|
| 1988 |
Hamilton AD, Pant N, Muehldorf A. Artificial receptors for biologically active molecules Pure and Applied Chemistry. 60: 533-538. DOI: 10.1351/Pac198860040533 |
0.347 |
|
| 1988 |
Hamilton AD, Pant N. Nucleotide base recognition: Ditopic binding of guanine to a macrocyclic receptor containing naphthyridine and naphthalene units Journal of the Chemical Society, Chemical Communications. 765-766. DOI: 10.1039/C39880000765 |
0.312 |
|
| 1987 |
Pant N, Mann M, Hamilton AD. Synthetic analogs of peptide-binding antibiotics Journal of Inclusion Phenomena. 5: 109-111. DOI: 10.1007/Bf00656412 |
0.322 |
|
| 1986 |
Larkins HL, Hamilton AD. Cyclopiperazines: A new approach to chiral macrocyclic receptors Tetrahedron Letters. 27: 2721-2724. DOI: 10.1016/S0040-4039(00)84626-2 |
0.305 |
|
| 1986 |
Hamilton A, Lehn JM, Sessler JL. Coreceptor molecules. Synthesis of metalloreceptors containing porphyrin subunits and formation of mixed substrate supermolecules by binding of organic substrates and of metal ions Journal of the American Chemical Society. 108: 5158-5167. DOI: 10.1002/Chin.198652259 |
0.53 |
|
| 1986 |
HAMILTON A, LEHN J, SESSLER JL. ChemInform Abstract: Coreceptor Molecules. Synthesis of Metalloreceptors Containing Porphyrin Subunits and Formation of Mixed Substrate Supermolecules by Binding of Organic Substrates and of Metal Ions. Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198652259 |
0.341 |
|
| 1986 |
Mann MJ, Pant N, Hamilton AD. A synthetic analogue of the carboxylate-binding pocket of vancomycin Journal of the Chemical Society, Chemical Communications. 158-160. DOI: 10.1002/Chin.198624327 |
0.318 |
|
| 1985 |
Hamilton AD, Kazanjian P. Synthesis of a molecular receptor containing two recognition sites Tetrahedron Letters. 26: 5735-5738. DOI: 10.1016/S0040-4039(00)98911-1 |
0.307 |
|
| 1984 |
Hamilton AD, Lehn JM, Sessler JL. Mixed substrate supermolecules: binding of organic substrates and of metal ions to heterotopic coreceptors containing porphyrin subunits Journal of the Chemical Society, Chemical Communications. 311-313. DOI: 10.1039/C39840000311 |
0.434 |
|
| 1982 |
Battersby AR, Howson W, Hamilton AD. Model studies on the active site of cytochrome P-450 : an FeII–porphyrin carrying a strapped thiolate ligand Journal of the Chemical Society, Chemical Communications. 1266-1268. DOI: 10.1039/C39820001266 |
0.477 |
|
| 1980 |
Battersby AR, Hamilton AD, McDonald E, Mombelli L, Wong OH. Biosynthesis of porphyrins and related macrocycles. Part 13. Structure of the protoporphyrin isomer derived from coproporphyrinogen IV by the action of beef-liver coproporphyrinogenase: synthesis of protoporphyrin XIII. Journal of the Chemical Society. Perkin Transactions 1. 6: 1283-9. PMID 7190574 DOI: 10.1039/P19800001283 |
0.478 |
|
| 1980 |
Cruse WB, Kennard O, Sheldrick GM, Hamilton AD, Hartley SG, Battersby AR. X-ray crystal structures of bridged porphyrins Journal of the Chemical Society, Chemical Communications. 700-701. DOI: 10.1039/C39800000700 |
0.473 |
|
| 1980 |
Battersby AR, Hamilton AD. Synthesis of a doubly-bridged oxygen-carrier which shows reduced affinity for carbon monoxide Journal of the Chemical Society, Chemical Communications. 117-119. DOI: 10.1039/C39800000117 |
0.487 |
|
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