| Year |
Citation |
Score |
| 2023 |
Shioi R, Xiao L, Kool ET. Aqueous Activation of RNA 2'-OH for Conjugation with Amines and Thiols. Bioconjugate Chemistry. PMID 38150592 DOI: 10.1021/acs.bioconjchem.3c00370 |
0.325 |
|
| 2023 |
Shioi R, Xiao L, Fang L, Kool ET. Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA 2'-acylation. Chemical Communications (Cambridge, England). 60: 232-235. PMID 38054242 DOI: 10.1039/d3cc05123d |
0.607 |
|
| 2023 |
Xiao L, Fang L, Kool ET. 2'-OH as a universal handle for studying intracellular RNAs. Cell Chemical Biology. PMID 37992716 DOI: 10.1016/j.chembiol.2023.10.022 |
0.605 |
|
| 2023 |
Fang L, Kool ET. Reactivity-based RNA profiling for analyzing transcriptome interactions of small molecules in human cells. Star Protocols. 4: 102670. PMID 37917579 DOI: 10.1016/j.xpro.2023.102670 |
0.592 |
|
| 2023 |
Xiao L, Fang L, Kool ET. RNA Infrastructure Profiling Illuminates Transcriptome Structure in Crowded Spaces. Biorxiv : the Preprint Server For Biology. PMID 37873487 DOI: 10.1101/2023.10.09.561413 |
0.611 |
|
| 2023 |
Fang L, Velema WA, Lee Y, Xiao L, Mohsen MG, Kietrys AM, Kool ET. Pervasive transcriptome interactions of protein-targeted drugs. Nature Chemistry. PMID 37653232 DOI: 10.1038/s41557-023-01309-8 |
0.78 |
|
| 2023 |
Jun YW, Kant M, Coskun E, Kato TA, Jaruga P, Palafox E, Dizdaroglu M, Kool ET. Possible Genetic Risks from Heat-Damaged DNA in Food. Acs Central Science. 9: 1170-1179. PMID 37396864 DOI: 10.1021/acscentsci.2c01247 |
0.319 |
|
| 2023 |
Fang L, Xiao L, Jun YW, Onishi Y, Kool ET. Reversible 2'-OH acylation enhances RNA stability. Nature Chemistry. PMID 37365334 DOI: 10.1038/s41557-023-01246-6 |
0.611 |
|
| 2022 |
Xiao L, Fang L, Chatterjee S, Kool ET. Diverse Reagent Scaffolds Provide Differential Selectivity of 2'-OH Acylation in RNA. Journal of the American Chemical Society. PMID 36542611 DOI: 10.1021/jacs.2c09040 |
0.613 |
|
| 2022 |
Jun YW, Kool ET. Chemical Tools for the Study of DNA Repair. Accounts of Chemical Research. PMID 36355579 DOI: 10.1021/acs.accounts.2c00608 |
0.395 |
|
| 2022 |
Jun YW, Harcourt EM, Xiao L, Wilson DL, Kool ET. Efficient DNA fluorescence labeling via base excision trapping. Nature Communications. 13: 5043. PMID 36028479 DOI: 10.1038/s41467-022-32494-8 |
0.378 |
|
| 2022 |
Lee Y, Onishi Y, McPherson L, Kietrys AM, Hebenbrock M, Jun YW, Das I, Adimoolam S, Ji D, Mohsen MG, Ford JM, Kool ET. Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1. Acs Chemical Biology. PMID 35830623 DOI: 10.1021/acschembio.2c00038 |
0.818 |
|
| 2022 |
Xiao L, Fang L, Kool ET. Acylation probing of "generic" RNA libraries reveals critical influence of loop constraints on reactivity. Cell Chemical Biology. PMID 35662395 DOI: 10.1016/j.chembiol.2022.05.005 |
0.626 |
|
| 2022 |
Jash B, Kool ET. Conjugation of RNA 2'-OH acylation: Mechanisms determining nucleotide reactivity. Chemical Communications (Cambridge, England). 58: 3693-3696. PMID 35226025 DOI: 10.1039/d2cc00660j |
0.761 |
|
| 2021 |
Xiao L, Jun YW, Kool ET. DNA tiling enables precise acylation-based labeling and control of mRNA. Angewandte Chemie (International Ed. in English). PMID 34624169 DOI: 10.1002/anie.202112106 |
0.335 |
|
| 2021 |
Park HS, Jash B, Xiao L, Jun YW, Kool ET. Control of RNA with quinone methide reversible acylating reagents. Organic & Biomolecular Chemistry. PMID 34528657 DOI: 10.1039/d1ob01713f |
0.77 |
|
| 2021 |
Moran S, Ren RX, Rumney S, Kool ET. Difluorotoluene, a Nonpolar Isostere for Thymine, Codes Specifically and Efficiently for Adenine in DNA Replication. Journal of the American Chemical Society. 119: 2056-2057. PMID 20737028 DOI: 10.1021/ja963718g |
0.321 |
|
| 2020 |
Kant M, Tahara YK, Jaruga P, Coskun E, Lloyd RS, Kool ET, Dizdaroglu M. Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products of Oxidatively induced DNA Base Lesions. Acs Chemical Biology. PMID 33331782 DOI: 10.1021/acschembio.0c00877 |
0.337 |
|
| 2020 |
Zhu RY, Majumdar C, Khuu C, De Rosa M, Opresko PL, David SS, Kool ET. Designer Fluorescent Adenines Enable Real-Time Monitoring of MUTYH Activity. Acs Central Science. 6: 1735-1742. PMID 33145410 DOI: 10.1021/Acscentsci.0C00369 |
0.436 |
|
| 2020 |
Qin S, Lin P, Wu Q, Pu Q, Zhou C, Wang B, Gao P, Wang Z, Gao A, Overby M, Yang J, Jiang J, Wilson DL, Tahara YK, Kool ET, et al. Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Infection. Journal of Immunology (Baltimore, Md. : 1950). PMID 32929043 DOI: 10.4049/Jimmunol.1901533 |
0.35 |
|
| 2020 |
Xiao L, Habibian M, Kool ET. Site-selective RNA Functionalization via DNA-induced Structure. Journal of the American Chemical Society. PMID 32865995 DOI: 10.1021/Jacs.0C06824 |
0.476 |
|
| 2020 |
Velema WA, Park HS, Kadina A, Orbai L, Kool ET. Trapping Transient RNA Complexes by Chemically Reversible Acylation. Angewandte Chemie (International Ed. in English). PMID 32845055 DOI: 10.1002/Anie.202010861 |
0.793 |
|
| 2020 |
Jun YW, Kool ET. Small Substrate or Large? Debate Over the Mechanism of Glycation Adduct Repair by DJ-1. Cell Chemical Biology. PMID 32783963 DOI: 10.1016/J.Chembiol.2020.07.016 |
0.321 |
|
| 2020 |
Jun YW, Wilson DL, Kietrys AM, Lotsof ER, Conlon SG, David SS, Kool ET. An Excimer Clamp for Measuring Damaged Base Excision by the DNA Repair Enzyme NTH1. Angewandte Chemie (International Ed. in English). PMID 32109332 DOI: 10.1002/Anie.202001516 |
0.459 |
|
| 2020 |
Schweitzer BA, Kool ET. Aromatic Nonpolar Nucleosides as Hydrophobic Isosteres of Pyrimidine and Purine Nucleosides. The Journal of Organic Chemistry. 59: 7238-7242. PMID 20882116 DOI: 10.1021/Jo00103A013 |
0.378 |
|
| 2020 |
Schweitzer BA, Kool ET. Hydrophobic, Non-Hydrogen-Bonding Bases and Base Pairs in DNA. Journal of the American Chemical Society. 117: 1863-1872. PMID 20882111 DOI: 10.1021/Ja00112A001 |
0.468 |
|
| 2020 |
Habibian M, McKinlay C, Blake TR, Kietrys AM, Waymouth RM, Wender PA, Kool ET. Reversible RNA acylation for control of CRISPR–Cas9 gene editing Chemical Science. 11: 1011-1016. DOI: 10.1039/C9Sc03639C |
0.312 |
|
| 2020 |
Jun YW, Wilson DL, Kietrys AM, Lotsof ER, Conlon SG, David SS, Kool ET. Corrigendum: An Excimer Clamp for Measuring Damaged‐Base Excision by the DNA Repair Enzyme NTH1 Angewandte Chemie International Edition. 59: 17327-17327. DOI: 10.1002/ANIE.202008220 |
0.321 |
|
| 2020 |
Jun YW, Wilson DL, Kietrys AM, Lotsof ER, Conlon SG, David SS, Kool ET. Berichtigung: An Excimer Clamp for Measuring Damaged‐Base Excision by the DNA Repair Enzyme NTH1 Angewandte Chemie. 132: 17479-17479. DOI: 10.1002/ANGE.202008220 |
0.321 |
|
| 2019 |
Habibian M, McKinlay C, Blake TR, Kietrys AM, Waymouth RM, Wender PA, Kool ET. Reversible RNA acylation for control of CRISPR-Cas9 gene editing. Chemical Science. 11: 1011-1016. PMID 34084356 DOI: 10.1039/c9sc03639c |
0.318 |
|
| 2019 |
Wilson DL, Kool ET. Ultrafast Oxime Formation Enables Efficient Fluorescence Light-up Measurement of DNA Base Excision. Journal of the American Chemical Society. PMID 31774658 DOI: 10.1021/Jacs.9B09812 |
0.516 |
|
| 2019 |
Samaranayake GJ, Troccoli CI, Zhang L, Huynh M, Jayaraj CJ, Ji D, McPherson L, Onishi Y, Nguyen DM, Robbins DJ, Karbaschi M, Cooke MS, Barrientos A, Kool ET, Rai P. The existence of MTH1-independent 8-oxodGTPase activity in cancer cells as a compensatory mechanism against on-target effects of MTH1 inhibitors. Molecular Cancer Therapeutics. PMID 31744893 DOI: 10.1158/1535-7163.Mct-19-0437 |
0.339 |
|
| 2019 |
Tahara YK, Kietrys AM, Hebenbrock M, Lee Y, Wilson DL, Kool ET. Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1. Acs Chemical Biology. PMID 31622553 DOI: 10.1021/Acschembio.9B00490 |
0.356 |
|
| 2019 |
Mohsen MG, Ji D, Kool ET. Polymerase synthesis of four-base DNA from two stable dimeric nucleotides. Nucleic Acids Research. PMID 31504784 DOI: 10.1093/Nar/Gkz741 |
0.837 |
|
| 2019 |
McPherson LA, Troccoli CI, Ji D, Bowles AE, Gardiner ML, Mohsen MG, Nagathihalli NS, Nguyen DM, Robbins DJ, Merchant NB, Kool ET, Rai P, Ford JM. Increased MTH1-specific 8-oxodGTPase activity is a hallmark of cancer in colon, lung and pancreatic tissue. Dna Repair. 102644. PMID 31311767 DOI: 10.1016/J.Dnarep.2019.102644 |
0.799 |
|
| 2019 |
Habibian M, Velema WA, Kietrys AM, Onishi Y, Kool ET. Polyacetate and Polycarbonate RNA: Acylating Reagents and Properties. Organic Letters. PMID 31268332 DOI: 10.1021/Acs.Orglett.9B01526 |
0.355 |
|
| 2019 |
Mohsen MG, Ji D, Kool ET. Polymerase-amplified release of ATP (POLARA) for detecting single nucleotide variants in RNA and DNA. Chemical Science. 10: 3264-3270. PMID 30996911 DOI: 10.1039/C8Sc03901A |
0.817 |
|
| 2019 |
Park HS, Kietrys AM, Kool ET. Simple alkanoyl acylating agents for reversible RNA functionalization and control. Chemical Communications (Cambridge, England). PMID 30977472 DOI: 10.1039/C9Cc01598A |
0.363 |
|
| 2019 |
Sun L, Fazal FM, Li P, Broughton JP, Lee B, Tang L, Huang W, Kool ET, Chang HY, Zhang QC. RNA structure maps across mammalian cellular compartments. Nature Structural & Molecular Biology. PMID 30886404 DOI: 10.1038/S41594-019-0200-7 |
0.356 |
|
| 2019 |
Nagel ZD, Beharry AA, Mazzucato P, Kitange GJ, Sarkaria JN, Kool ET, Samson LD. Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells. Plos One. 14: e0208341. PMID 30811507 DOI: 10.1371/Journal.Pone.0208341 |
0.419 |
|
| 2019 |
Matray TJ, Kool ET. Selective and Stable DNA Base Pairing without Hydrogen Bonds. Journal of the American Chemical Society. 120: 6191-6192. PMID 20852721 DOI: 10.1021/Ja9803310 |
0.482 |
|
| 2019 |
Xu Y, Kool ET. A Novel 5'-Iodonucleoside Allows Efficient Nonenzymatic Ligation of Single-stranded and Duplex DNAs. Tetrahedron Letters. 38: 5595-5598. PMID 19924262 DOI: 10.1016/S0040-4039(97)01266-5 |
0.522 |
|
| 2019 |
Kool ET. Preorganization of DNA: Design Principles for Improving Nucleic Acid Recognition by Synthetic Oligonucleotides. Chemical Reviews. 97: 1473-1488. PMID 11851456 DOI: 10.1021/Cr9603791 |
0.446 |
|
| 2018 |
Velema WA, Kool ET. Water-Soluble Leaving Group Enables Hydrophobic Functionalization of RNA. Organic Letters. PMID 30299958 DOI: 10.1021/Acs.Orglett.8B02938 |
0.337 |
|
| 2018 |
Wilson DL, Beharry AA, Srivastava A, O'Connor TR, Kool ET. Fluorescence Probes of ALKBH2 Measure DNA Alkylation Repair and Drug Resistance Responses. Angewandte Chemie (International Ed. in English). PMID 30098084 DOI: 10.1002/Anie.201807593 |
0.407 |
|
| 2018 |
Ji D, Kietrys AM, Lee Y, Kool ET. An ATP-linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase. Bioconjugate Chemistry. PMID 29578692 DOI: 10.1021/Acs.Bioconjchem.8B00124 |
0.406 |
|
| 2018 |
Velema WA, Kietrys AM, Kool ET. RNA Control by Photoreversible Acylation. Journal of the American Chemical Society. PMID 29474085 DOI: 10.1021/Jacs.7B12408 |
0.372 |
|
| 2018 |
Tahara YK, Auld D, Ji D, Beharry AA, Kietrys AM, Wilson DL, Jimenez M, King D, Nguyen Z, Kool ET. Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase (OGG1). Journal of the American Chemical Society. PMID 29376367 DOI: 10.1021/Jacs.7B09316 |
0.42 |
|
| 2018 |
Kadina A, Kietrys AM, Kool ET. RNA Cloaking by Reversible Acylation. Angewandte Chemie (International Ed. in English). PMID 29370460 DOI: 10.1002/Anie.201708696 |
0.392 |
|
| 2017 |
Wilson DL, Kool ET. Fluorescent probes of DNA repair. Acs Chemical Biology. PMID 29156135 DOI: 10.1021/Acschembio.7B00919 |
0.489 |
|
| 2017 |
Kietrys AM, Velema WAA, Kool ET. Fingerprints of Modified RNA Bases from Deep Sequencing Profiles. Journal of the American Chemical Society. PMID 29111692 DOI: 10.1021/Jacs.7B07914 |
0.381 |
|
| 2017 |
Xu W, Chan KM, Kool ET. Fluorescent nucleobases as tools for studying DNA and RNA. Nature Chemistry. 9: 1043-1055. PMID 29064490 DOI: 10.1038/Nchem.2859 |
0.466 |
|
| 2017 |
Ji D, Stepchenkova EI, Cui J, Menezes MR, Pavlov YI, Kool ET. Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimera. Nucleic Acids Research. PMID 29036687 DOI: 10.1093/Nar/Gkx774 |
0.384 |
|
| 2017 |
Chan KM, Xu W, Kwon H, Kietrys AM, Kool ET. Luminescent Carbon Dot Mimics Assembled on DNA. Journal of the American Chemical Society. PMID 28841010 DOI: 10.1021/Jacs.7B07420 |
0.374 |
|
| 2017 |
Chan KM, Kölmel DK, Wang S, Kool ET. Color-Change Photoswitching of an Alkynylpyrene Excimer Dye. Angewandte Chemie (International Ed. in English). PMID 28474388 DOI: 10.1002/Anie.201701235 |
0.751 |
|
| 2017 |
Velema WA, Kool ET. Fluorogenic Templated Reaction Cascades for RNA Detection. Journal of the American Chemical Society. PMID 28345912 DOI: 10.1021/Jacs.7B00466 |
0.343 |
|
| 2017 |
Kwon H, Chan KM, Kool ET. DNA as an environmental sensor: detection and identification of pesticide contaminants in water with fluorescent nucleobases. Organic & Biomolecular Chemistry. PMID 28150837 DOI: 10.1039/C6Ob02830F |
0.393 |
|
| 2017 |
Singh V, Wang S, Chan KM, Clark SA, Kool ET. Correction to "Genetically Encoded Multispectral Labeling of Proteins with Polyfluorophores on a DNA Backbone". Journal of the American Chemical Society. PMID 28128555 DOI: 10.1021/Jacs.6B11085 |
0.77 |
|
| 2017 |
Harcourt EM, Kietrys AM, Kool ET. Chemical and structural effects of base modifications in messenger RNA. Nature. 541: 339-346. PMID 28102265 DOI: 10.1038/Nature21351 |
0.388 |
|
| 2016 |
Clark SA, Singh V, Vega Mendoza D, Margolin W, Kool ET. Light-Up "Channel Dyes" for Haloalkane-Based Protein Labeling in Vitro and in Bacterial Cells. Bioconjugate Chemistry. 27: 2839-2843. PMID 27998074 DOI: 10.1021/Acs.Bioconjchem.6B00613 |
0.317 |
|
| 2016 |
Lee B, Flynn RA, Kadina A, Guo JK, Kool ET, Chang HY. Comparison of SHAPE Reagents for Mapping RNA Structures Inside Living Cells. Rna (New York, N.Y.). PMID 27879433 DOI: 10.1261/Rna.058784.116 |
0.362 |
|
| 2016 |
Mohsen MG, Kool ET. The Discovery of Rolling Circle Amplification and Rolling Circle Transcription. Accounts of Chemical Research. PMID 27797171 DOI: 10.1021/Acs.Accounts.6B00417 |
0.855 |
|
| 2016 |
Kent T, Rusanov TD, Hoang TM, Velema WA, Krueger AT, Copeland WC, Kool ET, Pomerantz RT. DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotides. Nucleic Acids Research. PMID 27591252 DOI: 10.1093/Nar/Gkw721 |
0.478 |
|
| 2016 |
Yuen LH, Saxena NS, Weinberg K, Park HS, Kool ET. Dark Hydrazone Fluorescence Labeling Agents Enable Imaging of Cellular Aldehydic Load. Acs Chemical Biology. PMID 27326450 DOI: 10.1021/Acschembio.6B00269 |
0.381 |
|
| 2016 |
Kölmel DK, Barandun LJ, Kool ET. Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores. Organic & Biomolecular Chemistry. PMID 27296353 DOI: 10.1039/C6Ob01199C |
0.415 |
|
| 2016 |
Hwang CS, Xu L, Wang W, Ulrich S, Zhang L, Chong J, Shin JH, Huang X, Kool ET, McKenna CE, Wang D. Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution. Nucleic Acids Research. PMID 27060150 DOI: 10.1093/Nar/Gkw220 |
0.608 |
|
| 2016 |
Oertell K, Harcourt EM, Mohsen MG, Petruska J, Kool ET, Goodman MF. Kinetic selection vs. free energy of DNA base pairing in control of polymerase fidelity. Proceedings of the National Academy of Sciences of the United States of America. PMID 27044101 DOI: 10.1073/Pnas.1600279113 |
0.826 |
|
| 2016 |
Beharry AA, Nagel ZD, Samson LD, Kool ET. Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response. Plos One. 11: e0152684. PMID 27035132 DOI: 10.1371/Journal.Pone.0152684 |
0.444 |
|
| 2016 |
Beharry AA, Lacoste S, O'Connor TR, Kool ET. Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker. Journal of the American Chemical Society. PMID 26967262 DOI: 10.1021/Jacs.6B00986 |
0.346 |
|
| 2016 |
Kietrys AM, Kool ET. Epigenetics: A new methyl mark on messengers. Nature. 530: 423-4. PMID 26911777 DOI: 10.1038/530423A |
0.395 |
|
| 2016 |
Flynn RA, Do BT, Rubin AJ, Calo E, Lee B, Kuchelmeister H, Rale M, Chu C, Kool ET, Wysocka J, Khavari PA, Chang HY. 7SK-BAF axis controls pervasive transcription at enhancers. Nature Structural & Molecular Biology. PMID 26878240 DOI: 10.1038/Nsmb.3176 |
0.367 |
|
| 2016 |
Ji D, Mohsen MG, Harcourt EM, Kool ET. ATP-Releasing Nucleotides: Linking DNA Synthesis to Luciferase Signaling. Angewandte Chemie (International Ed. in English). 55: 2087-91. PMID 26836342 DOI: 10.1002/Anie.201509131 |
0.837 |
|
| 2015 |
Kwon H, Jiang W, Kool ET. Correction: Pattern-based detection of anion pollutants in water with DNA polyfluorophores. Chemical Science. 6: 5086. PMID 30123454 DOI: 10.1039/C5Sc90036K |
0.365 |
|
| 2015 |
Karmakar S, Harcourt EM, Hewings DS, Scherer F, Lovejoy AF, Kurtz DM, Ehrenschwender T, Barandun LJ, Roost C, Alizadeh AA, Kool ET. Corrigendum: Organocatalytic removal of formaldehyde adducts from RNA and DNA bases. Nature Chemistry. 7: 1033. PMID 26587722 DOI: 10.1038/Nchem.2401 |
0.42 |
|
| 2015 |
Karmakar S, Harcourt EM, Hewings DS, Lovejoy AF, Kurtz DM, Ehrenschwender T, Barandun LJ, Roost C, Alizadeh AA, Kool ET. Organocatalytic removal of formaldehyde adducts from RNA and DNA bases. Nature Chemistry. 7: 752-8. PMID 26291948 DOI: 10.1038/Nchem.2307 |
0.406 |
|
| 2015 |
Kwon H, Jiang W, Kool ET. Pattern-Based Detection of Anion Pollutants in Water with DNA Polyfluorophores. Chemical Science (Royal Society of Chemistry : 2010). 6: 2575-2583. PMID 26146537 DOI: 10.1039/C4Sc03992K |
0.395 |
|
| 2015 |
Yuen LH, Franzini RM, Tan SS, Kool ET. Correction to "Large-Scale Detection of Metals with a Small Set of Fluorescent DNA-Like Chemosensors". Journal of the American Chemical Society. 137: 8309. PMID 26088103 DOI: 10.1021/Jacs.5B05859 |
0.376 |
|
| 2015 |
Roost C, Lynch SR, Batista PJ, Qu K, Chang HY, Kool ET. Correction to "Structure and Thermodynamics of N(6)-Methyladenosine in RNA: A Spring-Loaded Base Modification". Journal of the American Chemical Society. PMID 26087989 DOI: 10.1021/Jacs.5B05858 |
0.316 |
|
| 2015 |
Edwards SK, Ono T, Wang S, Jiang W, Franzini RM, Jung JW, Chan KM, Kool ET. In Vitro Fluorogenic Real-Time Assay of the Repair of Oxidative DNA Damage. Chembiochem : a European Journal of Chemical Biology. 16: 1637-46. PMID 26073452 DOI: 10.1002/Cbic.201500184 |
0.793 |
|
| 2015 |
Spitale RC, Flynn RA, Zhang QC, Crisalli P, Lee B, Jung JW, Kuchelmeister HY, Batista PJ, Torre EA, Kool ET, Chang HY. Structural imprints in vivo decode RNA regulatory mechanisms. Nature. 519: 486-90. PMID 25799993 DOI: 10.1038/Nature14263 |
0.364 |
|
| 2015 |
Roost C, Lynch SR, Batista PJ, Qu K, Chang HY, Kool ET. Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. Journal of the American Chemical Society. 137: 2107-15. PMID 25611135 DOI: 10.1021/Ja513080V |
0.385 |
|
| 2014 |
Yuen LH, Franzini RM, Tan SS, Kool ET. Large-scale detection of metals with a small set of fluorescent DNA-like chemosensors. Journal of the American Chemical Society. 136: 14576-82. PMID 25255102 DOI: 10.1021/Ja507932A |
0.332 |
|
| 2014 |
Spitale RC, Flynn RA, Torre EA, Kool ET, Chang HY. RNA structural analysis by evolving SHAPE chemistry. Wiley Interdisciplinary Reviews. Rna. 5: 867-81. PMID 25132067 DOI: 10.1002/Wrna.1253 |
0.39 |
|
| 2014 |
Xu L, Da L, Plouffe SW, Chong J, Kool E, Wang D. Molecular basis of transcriptional fidelity and DNA lesion-induced transcriptional mutagenesis. Dna Repair. 19: 71-83. PMID 24767259 DOI: 10.1016/J.Dnarep.2014.03.024 |
0.413 |
|
| 2014 |
Yuen LH, Franzini RM, Wang S, Crisalli P, Singh V, Jiang W, Kool ET. Pattern-based detection of toxic metals in surface water with DNA polyfluorophores. Angewandte Chemie (International Ed. in English). 53: 5361-5. PMID 24756982 DOI: 10.1002/Anie.201403235 |
0.731 |
|
| 2014 |
Xu L, Butler KV, Chong J, Wengel J, Kool ET, Wang D. Dissecting the chemical interactions and substrate structural signatures governing RNA polymerase II trigger loop closure by synthetic nucleic acid analogues. Nucleic Acids Research. 42: 5863-70. PMID 24692664 DOI: 10.1093/Nar/Gku238 |
0.363 |
|
| 2013 |
Harcourt EM, Ehrenschwender T, Batista PJ, Chang HY, Kool ET. Identification of a selective polymerase enables detection of N(6)-methyladenosine in RNA. Journal of the American Chemical Society. 135: 19079-82. PMID 24328136 DOI: 10.1021/Ja4105792 |
0.343 |
|
| 2013 |
Winnacker M, Kool ET. Artificial genetic sets composed of size-expanded base pairs. Angewandte Chemie (International Ed. in English). 52: 12498-508. PMID 24249550 DOI: 10.1002/Anie.201305267 |
0.367 |
|
| 2013 |
Jiang W, Wang S, Yuen LH, Kwon H, Ono T, Kool ET. DNA-polyfluorophore Chemosensors for Environmental Remediation: Vapor-phase Identification of Petroleum Products in Contaminated Soil. Chemical Science (Royal Society of Chemistry : 2010). 4: 3184-3190. PMID 23878719 DOI: 10.1039/C3Sc50985K |
0.743 |
|
| 2013 |
Ono T, Edwards SK, Wang S, Jiang W, Kool ET. Monitoring eukaryotic and bacterial UDG repair activity with DNA-multifluorophore sensors. Nucleic Acids Research. 41: e127. PMID 23644286 DOI: 10.1093/Nar/Gkt309 |
0.771 |
|
| 2013 |
Singh V, Wang S, Kool ET. Genetically encoded multispectral labeling of proteins with polyfluorophores on a DNA backbone. Journal of the American Chemical Society. 135: 6184-91. PMID 23590213 DOI: 10.1021/Ja4004393 |
0.767 |
|
| 2013 |
Jung JW, Edwards SK, Kool ET. Selective fluorogenic chemosensors for distinct classes of nucleases. Chembiochem : a European Journal of Chemical Biology. 14: 440-4. PMID 23371801 DOI: 10.1002/Cbic.201300001 |
0.377 |
|
| 2013 |
Spitale RC, Crisalli P, Flynn RA, Torre EA, Kool ET, Chang HY. RNA SHAPE analysis in living cells. Nature Chemical Biology. 9: 18-20. PMID 23178934 DOI: 10.1038/Nchembio.1131 |
0.387 |
|
| 2013 |
Attwater J, Tagami S, Kimoto M, Butler K, Kool ET, Wengel J, Herdewijn P, Hirao I, Holliger P. Chemical fidelity of an RNA polymerase ribozyme Chemical Science. 4: 2804-2814. DOI: 10.1039/C3Sc50574J |
0.424 |
|
| 2012 |
Crisalli P, Hernández AR, Kool ET. Fluorescence quenchers for hydrazone and oxime orthogonal bioconjugation. Bioconjugate Chemistry. 23: 1969-80. PMID 22913527 DOI: 10.1021/Bc300344B |
0.434 |
|
| 2012 |
Lee SH, Wang S, Kool ET. Templated chemistry for monitoring damage and repair directly in duplex DNA. Chemical Communications (Cambridge, England). 48: 8069-71. PMID 22782065 DOI: 10.1039/C2Cc34060G |
0.805 |
|
| 2012 |
Wang S, Guo J, Ono T, Kool ET. DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems. Angewandte Chemie (International Ed. in English). 51: 7176-80. PMID 22684777 DOI: 10.1002/Anie.201201928 |
0.757 |
|
| 2012 |
Hernández AR, Peterson LW, Kool ET. Steric restrictions of RISC in RNA interference identified with size-expanded RNA nucleobases. Acs Chemical Biology. 7: 1454-61. PMID 22646660 DOI: 10.1021/Cb300174C |
0.704 |
|
| 2012 |
Kellinger MW, Ulrich S, Chong J, Kool ET, Wang D. Dissecting chemical interactions governing RNA polymerase II transcriptional fidelity. Journal of the American Chemical Society. 134: 8231-40. PMID 22509745 DOI: 10.1021/Ja302077D |
0.446 |
|
| 2012 |
Teo YN, Kool ET. DNA-multichromophore systems. Chemical Reviews. 112: 4221-45. PMID 22424059 DOI: 10.1021/Cr100351G |
0.423 |
|
| 2012 |
Khakshoor O, Wheeler SE, Houk KN, Kool ET. Measurement and theory of hydrogen bonding contribution to isosteric DNA base pairs. Journal of the American Chemical Society. 134: 3154-63. PMID 22300089 DOI: 10.1021/Ja210475A |
0.446 |
|
| 2012 |
Harcourt EM, Kool ET. Amplified microRNA detection by templated chemistry. Nucleic Acids Research. 40: e65. PMID 22278881 DOI: 10.1093/Nar/Gkr1313 |
0.302 |
|
| 2012 |
Ono T, Wang S, Koo CK, Engstrom L, David SS, Kool ET. Direct fluorescence monitoring of DNA base excision repair. Angewandte Chemie (International Ed. in English). 51: 1689-92. PMID 22241823 DOI: 10.1002/Anie.201108135 |
0.808 |
|
| 2012 |
McKibbin PL, Kobori A, Taniguchi Y, Kool ET, David SS. Surprising repair activities of nonpolar analogs of 8-oxoG expose features of recognition and catalysis by base excision repair glycosylases. Journal of the American Chemical Society. 134: 1653-61. PMID 22175854 DOI: 10.1021/Ja208510M |
0.445 |
|
| 2012 |
Kwon H, Samain F, Kool ET. Fluorescent DNAs printed on paper: Sensing food spoilage and ripening in the vapor phase Chemical Science. 3: 2542-2549. DOI: 10.1039/C2Sc20461D |
0.343 |
|
| 2011 |
Ulrich S, Kool ET. Importance of steric effects on the efficiency and fidelity of transcription by T7 RNA polymerase. Biochemistry. 50: 10343-9. PMID 22044042 DOI: 10.1021/Bi2011465 |
0.474 |
|
| 2011 |
Crisalli P, Kool ET. Multi-path quenchers: efficient quenching of common fluorophores. Bioconjugate Chemistry. 22: 2345-54. PMID 22034828 DOI: 10.1021/Bc200424R |
0.361 |
|
| 2011 |
Krueger AT, Peterson LW, Chelliserry J, Kleinbaum DJ, Kool ET. Encoding phenotype in bacteria with an alternative genetic set. Journal of the American Chemical Society. 133: 18447-51. PMID 21981660 DOI: 10.1021/Ja208025E |
0.734 |
|
| 2011 |
Koo CK, Wang S, Gaur RL, Samain F, Banaei N, Kool ET. Fluorescent DNA chemosensors: identification of bacterial species by their volatile metabolites. Chemical Communications (Cambridge, England). 47: 11435-7. PMID 21935547 DOI: 10.1039/C1Cc14871K |
0.763 |
|
| 2011 |
Franzini RM, Kool ET. Improved templated fluorogenic probes enhance the analysis of closely related pathogenic bacteria by microscopy and flow cytometry. Bioconjugate Chemistry. 22: 1869-77. PMID 21870777 DOI: 10.1021/Bc2003567 |
0.341 |
|
| 2011 |
Khakshoor O, Kool ET. Chemistry of nucleic acids: impacts in multiple fields. Chemical Communications (Cambridge, England). 47: 7018-24. PMID 21483917 DOI: 10.1039/C1Cc11021G |
0.328 |
|
| 2011 |
Dai N, Guo J, Teo YN, Kool ET. Protease probes built from DNA: multispectral fluorescent DNA-peptide conjugates as caspase chemosensors. Angewandte Chemie (International Ed. in English). 50: 5105-9. PMID 21455915 DOI: 10.1002/Anie.201007805 |
0.385 |
|
| 2011 |
Guo J, Wang S, Dai N, Teo YN, Kool ET. Multispectral labeling of antibodies with polyfluorophores on a DNA backbone and application in cellular imaging. Proceedings of the National Academy of Sciences of the United States of America. 108: 3493-8. PMID 21321224 DOI: 10.1073/Pnas.1017349108 |
0.74 |
|
| 2011 |
Franzini RM, Kool ET. Two successive reactions on a DNA template: a strategy for improving background fluorescence and specificity in nucleic acid detection. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 2168-75. PMID 21294182 DOI: 10.1002/Chem.201002426 |
0.459 |
|
| 2011 |
Dai N, Kool ET. Fluorescent DNA-based enzyme sensors. Chemical Society Reviews. 40: 5756-70. PMID 21290032 DOI: 10.1039/C0Cs00162G |
0.432 |
|
| 2011 |
Hernández AR, Kool ET. The components of xRNA: synthesis and fluorescence of a full genetic set of size-expanded ribonucleosides. Organic Letters. 13: 676-9. PMID 21214222 DOI: 10.1021/Ol102915F |
0.371 |
|
| 2011 |
Jarchow-Choy SK, Krueger AT, Liu H, Gao J, Kool ET. Fluorescent xDNA nucleotides as efficient substrates for a template-independent polymerase. Nucleic Acids Research. 39: 1586-94. PMID 20947563 DOI: 10.1093/Nar/Gkq853 |
0.695 |
|
| 2011 |
Koo CK, Samain F, Dai N, Kool ET. DNA polyfluorophores as highly diverse chemosensors of toxic gases Chemical Science. 2: 1910-1917. DOI: 10.1039/C1Sc00301A |
0.435 |
|
| 2010 |
Kleinbaum DJ, Kool ET. Sandwich probes: two simultaneous reactions for templated nucleic acid detection. Chemical Communications (Cambridge, England). 46: 8154-6. PMID 20927470 DOI: 10.1039/C0Cc01968B |
0.472 |
|
| 2010 |
Tan SS, Teo YN, Kool ET. Selective sensor for silver ions built from polyfluorophores on a DNA backbone. Organic Letters. 12: 4820-3. PMID 20883041 DOI: 10.1021/Ol1019794 |
0.319 |
|
| 2010 |
Li H, Franzini RM, Bruner C, Kool ET. Templated chemistry for sequence-specific fluorogenic detection of duplex DNA. Chembiochem : a European Journal of Chemical Biology. 11: 2132-7. PMID 20859985 DOI: 10.1002/Cbic.201000329 |
0.509 |
|
| 2010 |
Killelea T, Ghosh S, Tan SS, Heslop P, Firbank SJ, Kool ET, Connolly BA. Probing the interaction of archaeal DNA polymerases with deaminated bases using X-ray crystallography and non-hydrogen bonding isosteric base analogues. Biochemistry. 49: 5772-81. PMID 20527806 DOI: 10.1021/Bi100421R |
0.518 |
|
| 2010 |
Kleinbaum DJ, Miller GP, Kool ET. Double displacement: An improved bioorthogonal reaction strategy for templated nucleic acid detection. Bioconjugate Chemistry. 21: 1115-20. PMID 20509625 DOI: 10.1021/Bc100165H |
0.695 |
|
| 2010 |
Dai N, Teo YN, Kool ET. DNA-polyfluorophore excimers as sensitive reporters for esterases and lipases. Chemical Communications (Cambridge, England). 46: 1221-3. PMID 20449256 DOI: 10.1039/B926338A |
0.492 |
|
| 2010 |
Lu H, Krueger AT, Gao J, Liu H, Kool ET. Toward a designed genetic system with biochemical function: polymerase synthesis of single and multiple size-expanded DNA base pairs. Organic & Biomolecular Chemistry. 8: 2704-10. PMID 20407680 DOI: 10.1039/C002766A |
0.8 |
|
| 2010 |
GUPTA V, KOOL ET. ChemInform Abstract: A Self-Cleaving DNA Nucleoside. Cheminform. 28: no-no. DOI: 10.1002/CHIN.199747254 |
0.303 |
|
| 2010 |
KOOL ET. ChemInform Abstract: Preorganization of DNA: Design Principles for Improving Nucleic Acid Recognition by Synthetic Oligonucleotides Cheminform. 28: no-no. DOI: 10.1002/CHIN.199744335 |
0.311 |
|
| 2010 |
REN RX, CHAUDHURI NC, PARIS PL, RUMNEY SI, KOOL ET. ChemInform Abstract: Naphthalene, Phenanthrene, and Pyrene as DNA Base Analogues: Synthesis, Structure, and Fluorescence in DNA. Cheminform. 27: no-no. DOI: 10.1002/CHIN.199648250 |
0.407 |
|
| 2009 |
Jarchow-Choy SK, Sjuvarsson E, Sintim HO, Eriksson S, Kool ET. Nonpolar nucleoside mimics as active substrates for human thymidine kinases. Journal of the American Chemical Society. 131: 5488-94. PMID 20560637 DOI: 10.1021/Ja808244T |
0.582 |
|
| 2009 |
Teo YN, Kool ET. Polyfluorophore excimers and exciplexes as FRET donors in DNA. Bioconjugate Chemistry. 20: 2371-80. PMID 19916519 DOI: 10.1021/Bc9003926 |
0.411 |
|
| 2009 |
Franzini RM, Kool ET. Efficient nucleic acid detection by templated reductive quencher release. Journal of the American Chemical Society. 131: 16021-3. PMID 19886694 DOI: 10.1021/Ja904138V |
0.394 |
|
| 2009 |
Teo YN, Wilson JN, Kool ET. Polyfluorophore labels on DNA: dramatic sequence dependence of quenching. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 11551-8. PMID 19780115 DOI: 10.1002/Chem.200901607 |
0.419 |
|
| 2009 |
Lu H, Lynch SR, Lee AH, Kool ET. Structure and replication of yDNA: a novel genetic set widened by benzo-homologation. Chembiochem : a European Journal of Chemical Biology. 10: 2530-8. PMID 19780073 DOI: 10.1002/Cbic.200900434 |
0.649 |
|
| 2009 |
Loakes D, Gallego J, Pinheiro VB, Kool ET, Holliger P. Evolving a polymerase for hydrophobic base analogues. Journal of the American Chemical Society. 131: 14827-37. PMID 19778048 DOI: 10.1021/Ja9039696 |
0.441 |
|
| 2009 |
Delaney JC, Gao J, Liu H, Shrivastav N, Essigmann JM, Kool ET. Efficient replication bypass of size-expanded DNA base pairs in bacterial cells. Angewandte Chemie (International Ed. in English). 48: 4524-7. PMID 19444841 DOI: 10.1002/Anie.200805683 |
0.749 |
|
| 2009 |
Krueger AT, Kool ET. Redesigning the architecture of the base pair: toward biochemical and biological function of new genetic sets. Chemistry & Biology. 16: 242-8. PMID 19318205 DOI: 10.1016/J.Chembiol.2008.12.004 |
0.419 |
|
| 2009 |
Teo YN, Wilson JN, Kool ET. Polyfluorophores on a DNA backbone: a multicolor set of labels excited at one wavelength. Journal of the American Chemical Society. 131: 3923-33. PMID 19254023 DOI: 10.1021/Ja805502K |
0.339 |
|
| 2009 |
Terrazas M, Kool ET. RNA major groove modifications improve siRNA stability and biological activity. Nucleic Acids Research. 37: 346-53. PMID 19042976 DOI: 10.1093/Nar/Gkn958 |
0.403 |
|
| 2009 |
Sintim HO, Kool ET. Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine (Journal of the American Chemical Society (2006) 128, (396-397)) Journal of the American Chemical Society. 131: 11270. DOI: 10.1021/ja905423u |
0.517 |
|
| 2008 |
Chelliserrykattil J, Lu H, Lee AH, Kool ET. Polymerase amplification, cloning, and gene expression of benzo-homologous "yDNA" base pairs. Chembiochem : a European Journal of Chemical Biology. 9: 2976-80. PMID 19053129 DOI: 10.1002/Cbic.200800339 |
0.678 |
|
| 2008 |
Franzini RM, Kool ET. 7-Azidomethoxy-coumarins as profluorophores for templated nucleic acid detection. Chembiochem : a European Journal of Chemical Biology. 9: 2981-8. PMID 19035374 DOI: 10.1002/Cbic.200800507 |
0.504 |
|
| 2008 |
Pomerantz AK, Moerner WE, Kool ET. Visualization of long human telomere mimics by single-molecule fluorescence imaging. The Journal of Physical Chemistry. B. 112: 13184-7. PMID 18817431 DOI: 10.1021/Jp806696U |
0.475 |
|
| 2008 |
Krueger AT, Lu H, Højland T, Liu H, Gao J, Kool ET. Towards the replication of xDNA, a size-expanded unnatural genetic system. Nucleic Acids Symposium Series (2004). 455-6. PMID 18776450 DOI: 10.1093/nass/nrn231 |
0.757 |
|
| 2008 |
Teo YN, Kool ET. Studies of oligodeoxyfluorosides (ODFs) as FRET probes for DNA hybridization. Nucleic Acids Symposium Series (2004). 233-4. PMID 18776339 DOI: 10.1093/nass/nrn118 |
0.391 |
|
| 2008 |
Silverman AP, Abe H, Kool ET. Quenched autoligation probes. Methods in Molecular Biology (Clifton, N.J.). 429: 161-70. PMID 18695965 DOI: 10.1007/978-1-60327-040-3_11 |
0.724 |
|
| 2008 |
Somoza A, Silverman AP, Miller RM, Chelliserrykattil J, Kool ET. Steric effects in RNA interference: probing the influence of nucleobase size and shape. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 7978-87. PMID 18624291 DOI: 10.1002/Chem.200800837 |
0.711 |
|
| 2008 |
Franzini RM, Kool ET. Organometallic activation of a fluorogen for templated nucleic acid detection. Organic Letters. 10: 2935-8. PMID 18549220 DOI: 10.1021/Ol800878B |
0.477 |
|
| 2008 |
Silverman AP, Garforth SJ, Prasad VR, Kool ET. Probing the active site steric flexibility of HIV-1 reverse transcriptase: different constraints for DNA- versus RNA-templated synthesis. Biochemistry. 47: 4800-7. PMID 18366188 DOI: 10.1021/Bi702427Y |
0.776 |
|
| 2008 |
Krueger AT, Kool ET. Fluorescence of size-expanded DNA bases: reporting on DNA sequence and structure with an unnatural genetic set. Journal of the American Chemical Society. 130: 3989-99. PMID 18311973 DOI: 10.1021/Ja0782347 |
0.497 |
|
| 2008 |
Wilson JN, Cho Y, Tan S, Cuppoletti A, Kool ET. Quenching of fluorescent nucleobases by neighboring DNA: the "insulator" concept. Chembiochem : a European Journal of Chemical Biology. 9: 279-85. PMID 18072185 DOI: 10.1002/Cbic.200700381 |
0.64 |
|
| 2008 |
Livingston AL, O'Shea VL, Kim T, Kool ET, David SS. Unnatural substrates reveal the importance of 8-oxoguanine for in vivo mismatch repair by MutY. Nature Chemical Biology. 4: 51-8. PMID 18026095 DOI: 10.1038/Nchembio.2007.40 |
0.421 |
|
| 2008 |
Lee HR, Helquist SA, Kool ET, Johnson KA. Base pair hydrogen bonds are essential for proofreading selectivity by the human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 283: 14411-6. PMID 17650503 DOI: 10.1074/Jbc.M705006200 |
0.817 |
|
| 2008 |
Lee HR, Helquist SA, Kool ET, Johnson KA. Importance of hydrogen bonding for efficiency and specificity of the human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 283: 14402-10. PMID 17650502 DOI: 10.1074/Jbc.M705007200 |
0.821 |
|
| 2008 |
Miller GP, Silverman AP, Kool ET. New, stronger nucleophiles for nucleic acid-templated chemistry: Synthesis and application in fluorescence detection of cellular RNA. Bioorganic & Medicinal Chemistry. 16: 56-64. PMID 17502150 DOI: 10.1016/J.Bmc.2007.04.051 |
0.824 |
|
| 2008 |
Kool ET. Modified DNA Bases: Probing Base-Pair Recognition by Polymerases Modified Nucleosides: in Biochemistry, Biotechnology and Medicine. 49-74. DOI: 10.1002/9783527623112.ch3 |
0.418 |
|
| 2007 |
Taniguchi Y, Kool ET. Syntheses and properties of low-polarity shape mimics of 8-oxopurines. Nucleic Acids Symposium Series (2004). 217-8. PMID 18029664 DOI: 10.1093/nass/nrm109 |
0.417 |
|
| 2007 |
Wilson JN, Teo YN, Kool ET. Efficient quenching of oligomeric fluorophores on a DNA backbone. Journal of the American Chemical Society. 129: 15426-7. PMID 18027944 DOI: 10.1021/Ja075968A |
0.367 |
|
| 2007 |
Silverman AP, Jiang Q, Goodman MF, Kool ET. Steric and electrostatic effects in DNA synthesis by the SOS-induced DNA polymerases II and IV of Escherichia coli. Biochemistry. 46: 13874-81. PMID 17988102 DOI: 10.1021/Bi700851Z |
0.766 |
|
| 2007 |
Krueger AT, Kool ET. Model systems for understanding DNA base pairing. Current Opinion in Chemical Biology. 11: 588-94. PMID 17967435 DOI: 10.1016/J.Cbpa.2007.09.019 |
0.39 |
|
| 2007 |
Wilson JN, Gao J, Kool ET. Oligodeoxyfluorosides: Strong Sequence Dependence of Fluorescence Emission. Tetrahedron. 63: 3427-3433. PMID 17940588 DOI: 10.1016/J.Tet.2006.07.113 |
0.571 |
|
| 2007 |
Silverman AP, Kool ET. RNA probes of steric effects in active sites: high flexibility of HIV-1 reverse transcriptase. Journal of the American Chemical Society. 129: 10626-7. PMID 17696348 DOI: 10.1021/Ja072791B |
0.722 |
|
| 2007 |
Taniguchi Y, Kool ET. Nonpolar isosteres of damaged DNA bases: effective mimicry of mutagenic properties of 8-oxopurines. Journal of the American Chemical Society. 129: 8836-44. PMID 17592846 DOI: 10.1021/Ja071970Q |
0.536 |
|
| 2007 |
Krueger AT, Lu H, Lee AH, Kool ET. Synthesis and properties of size-expanded DNAs: toward designed, functional genetic systems. Accounts of Chemical Research. 40: 141-50. PMID 17309194 DOI: 10.1021/Ar068200O |
0.678 |
|
| 2007 |
Silverman AP, Kool ET. Oligonucleotide probes for RNA-targeted fluorescence in situ hybridization. Advances in Clinical Chemistry. 43: 79-115. PMID 17249381 DOI: 10.1016/S0065-2423(06)43003-1 |
0.683 |
|
| 2007 |
Kool ET, Waters ML. The model student: what chemical model systems can teach us about biology. Nature Chemical Biology. 3: 70-3. PMID 17235337 DOI: 10.1038/Nchembio0207-70 |
0.556 |
|
| 2007 |
Garforth SJ, Kim TW, Parniak MA, Kool ET, Prasad VR. Site-directed mutagenesis in the fingers subdomain of HIV-1 reverse transcriptase reveals a specific role for the beta3-beta4 hairpin loop in dNTP selection. Journal of Molecular Biology. 365: 38-49. PMID 17055529 DOI: 10.1016/J.Jmb.2006.09.057 |
0.313 |
|
| 2006 |
Kool ET, Lu H, Kim SJ, Tan S, Wilson JN, Gao J, Liu H. New designs for DNA bases: expanded DNAs and oligofluorosides. Nucleic Acids Symposium Series (2004). 15-6. PMID 17150794 DOI: 10.1093/nass/nrl008 |
0.785 |
|
| 2006 |
Wilson JN, Kool ET. Fluorescent DNA base replacements: Reporters and sensors for biological systems. Organic & Biomolecular Chemistry. 4: 4265-74. PMID 17102869 DOI: 10.1039/B612284C |
0.487 |
|
| 2006 |
Lynch SR, Liu H, Gao J, Kool ET. Toward a designed, functioning genetic system with expanded-size base pairs: solution structure of the eight-base xDNA double helix. Journal of the American Chemical Society. 128: 14704-11. PMID 17090058 DOI: 10.1021/Ja065606N |
0.725 |
|
| 2006 |
Kool ET, Sintim HO. The difluorotoluene debate--a decade later. Chemical Communications (Cambridge, England). 3665-75. PMID 17047807 DOI: 10.1039/B605414E |
0.692 |
|
| 2006 |
Silverman AP, Baron EJ, Kool ET. RNA-templated chemistry in cells: discrimination of Escherichia, Shigella and Salmonella bacterial strains with a new two-color FRET strategy. Chembiochem : a European Journal of Chemical Biology. 7: 1890-4. PMID 17031884 DOI: 10.1002/Cbic.200600278 |
0.681 |
|
| 2006 |
Yakovleva L, Lai J, Kool ET, Shuman S. Nonpolar nucleobase analogs illuminate requirements for site-specific DNA cleavage by vaccinia topoisomerase. The Journal of Biological Chemistry. 281: 35914-21. PMID 17005552 DOI: 10.1074/Jbc.M608349200 |
0.692 |
|
| 2006 |
Silverman AP, Kool ET. Detecting RNA and DNA with templated chemical reactions. Chemical Reviews. 106: 3775-89. PMID 16967920 DOI: 10.1021/Cr050057+ |
0.754 |
|
| 2006 |
Lee AH, Kool ET. Exploring the limits of DNA size: naphtho-homologated DNA bases and pairs. Journal of the American Chemical Society. 128: 9219-30. PMID 16834396 DOI: 10.1021/Ja0619004 |
0.525 |
|
| 2006 |
Somoza A, Chelliserrykattil J, Kool ET. The roles of hydrogen bonding and sterics in RNA interference. Angewandte Chemie (International Ed. in English). 45: 4994-7. PMID 16802393 DOI: 10.1002/Anie.200601311 |
0.345 |
|
| 2006 |
Sintim HO, Kool ET. Remarkable sensitivity to DNA base shape in the DNA polymerase active site. Angewandte Chemie (International Ed. in English). 45: 1974-9. PMID 16506248 DOI: 10.1002/Anie.200504296 |
0.689 |
|
| 2006 |
Hariharan C, Bloom LB, Helquist SA, Kool ET, Reha-Krantz LJ. Dynamics of nucleotide incorporation: snapshots revealed by 2-aminopurine fluorescence studies. Biochemistry. 45: 2836-44. PMID 16503638 DOI: 10.1021/Bi051644S |
0.826 |
|
| 2006 |
Mizukami S, Kim TW, Helquist SA, Kool ET. Varying DNA base-pair size in subangstrom increments: evidence for a loose, not large, active site in low-fidelity Dpo4 polymerase. Biochemistry. 45: 2772-8. PMID 16503632 DOI: 10.1021/Bi051961Z |
0.827 |
|
| 2006 |
Cho Y, Kool ET. Enzymatic synthesis of fluorescent oligomers assembled on a DNA backbone. Chembiochem : a European Journal of Chemical Biology. 7: 669-72. PMID 16502476 DOI: 10.1002/Cbic.200500515 |
0.649 |
|
| 2006 |
Potapova O, Chan C, DeLucia AM, Helquist SA, Kool ET, Grindley ND, Joyce CM. DNA polymerase catalysis in the absence of Watson-Crick hydrogen bonds: analysis by single-turnover kinetics. Biochemistry. 45: 890-8. PMID 16411765 DOI: 10.1021/Bi051792I |
0.817 |
|
| 2006 |
Sintim HO, Kool ET. Enhanced base pairing and replication efficiency of thiothymidines, expanded-size variants of thymidine. Journal of the American Chemical Society. 128: 396-7. PMID 16402811 DOI: 10.1021/Ja0562447 |
0.631 |
|
| 2006 |
Abe H, Kool ET. Flow cytometric detection of specific RNAs in native human cells with quenched autoligating FRET probes. Proceedings of the National Academy of Sciences of the United States of America. 103: 263-8. PMID 16384914 DOI: 10.1073/Pnas.0509938103 |
0.387 |
|
| 2006 |
Kim TW, Brieba LG, Ellenberger T, Kool ET. Functional evidence for a small and rigid active site in a high fidelity DNA polymerase: probing T7 DNA polymerase with variably sized base pairs. The Journal of Biological Chemistry. 281: 2289-95. PMID 16311403 DOI: 10.1074/Jbc.M510744200 |
0.47 |
|
| 2005 |
Abe H, Kool ET. Universal linkers for signal amplification in auto-ligating probes. Nucleic Acids Symposium Series (2004). 37-8. PMID 17150621 DOI: 10.1093/nass/49.1.37 |
0.351 |
|
| 2005 |
Silverman AP, Kool ET. Quenched autoligation probes allow discrimination of live bacterial species by single nucleotide differences in rRNA. Nucleic Acids Research. 33: 4978-86. PMID 16284198 DOI: 10.1093/Nar/Gki814 |
0.699 |
|
| 2005 |
Hartig JS, Kool ET. Efficient isothermal expansion of human telomeric and minisatellite repeats by Thermococcus litoralis DNA polymerase. Nucleic Acids Research. 33: 4922-7. PMID 16284196 DOI: 10.1093/Nar/Gki803 |
0.508 |
|
| 2005 |
Kim TW, Delaney JC, Essigmann JM, Kool ET. Probing the active site tightness of DNA polymerase in subangstrom increments. Proceedings of the National Academy of Sciences of the United States of America. 102: 15803-8. PMID 16249340 DOI: 10.1073/Pnas.0505113102 |
0.492 |
|
| 2005 |
Wolfle WT, Washington MT, Kool ET, Spratt TE, Helquist SA, Prakash L, Prakash S. Evidence for a Watson-Crick hydrogen bonding requirement in DNA synthesis by human DNA polymerase kappa. Molecular and Cellular Biology. 25: 7137-43. PMID 16055723 DOI: 10.1128/Mcb.25.16.7137-7143.2005 |
0.842 |
|
| 2005 |
Hartig JS, Fernandez-Lopez S, Kool ET. Guanine-rich DNA nanocircles for the synthesis and characterization of long cytosine-rich telomeric DNAs. Chembiochem : a European Journal of Chemical Biology. 6: 1458-62. PMID 16052615 DOI: 10.1002/Cbic.200500015 |
0.528 |
|
| 2005 |
Devaraj NK, Miller GP, Ebina W, Kakaradov B, Collman JP, Kool ET, Chidsey CE. Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers. Journal of the American Chemical Society. 127: 8600-1. PMID 15954758 DOI: 10.1021/Ja051462L |
0.654 |
|
| 2005 |
Cuppoletti A, Cho Y, Park JS, Strässler C, Kool ET. Oligomeric fluorescent labels for DNA. Bioconjugate Chemistry. 16: 528-34. PMID 15898718 DOI: 10.1021/Bc0497766 |
0.61 |
|
| 2005 |
Silverman AP, Kool ET. Quenched probes for highly specific detection of cellular RNAs. Trends in Biotechnology. 23: 225-30. PMID 15865999 DOI: 10.1016/J.Tibtech.2005.03.007 |
0.732 |
|
| 2005 |
Gao J, Liu H, Kool ET. Assembly of the complete eight-base artificial genetic helix, xDNA, and its interaction with the natural genetic system. Angewandte Chemie (International Ed. in English). 44: 3118-22. PMID 15834852 DOI: 10.1002/Anie.200500069 |
0.612 |
|
| 2005 |
Kim TW, Kool ET. A series of nonpolar thymidine analogues of increasing size: DNA base pairing and stacking properties. The Journal of Organic Chemistry. 70: 2048-53. PMID 15760186 DOI: 10.1021/Jo048061T |
0.485 |
|
| 2005 |
Lee AH, Kool ET. A new four-base genetic helix, yDNA, composed of widened benzopyrimidine-purine pairs. Journal of the American Chemical Society. 127: 3332-8. PMID 15755149 DOI: 10.1021/Ja0430604 |
0.503 |
|
| 2005 |
Lai JS, Kool ET. Fluorous base-pairing effects in a DNA polymerase active site. Chemistry (Weinheim An Der Bergstrasse, Germany). 11: 2966-71. PMID 15744767 DOI: 10.1002/Chem.200401151 |
0.704 |
|
| 2005 |
Liu H, Gao J, Kool ET. Helix-forming properties of size-expanded DNA, an alternative four-base genetic form. Journal of the American Chemical Society. 127: 1396-402. PMID 15686371 DOI: 10.1021/Ja046305L |
0.74 |
|
| 2005 |
Yoshina-Ishii C, Miller GP, Kraft ML, Kool ET, Boxer SG. General method for modification of liposomes for encoded assembly on supported bilayers. Journal of the American Chemical Society. 127: 1356-7. PMID 15686351 DOI: 10.1021/Ja043299K |
0.734 |
|
| 2005 |
Liu H, Gao J, Kool ET. Size-expanded analogues of dG and dC: synthesis and pairing properties in DNA. The Journal of Organic Chemistry. 70: 639-47. PMID 15651812 DOI: 10.1021/Jo048357Z |
0.76 |
|
| 2005 |
Lee AH, Kool ET. Novel benzopyrimidines as widened analogues of DNA bases. The Journal of Organic Chemistry. 70: 132-40. PMID 15624915 DOI: 10.1021/Jo0483973 |
0.511 |
|
| 2004 |
Lu H, He K, Kool ET. yDNA: a new geometry for size-expanded base pairs. Angewandte Chemie (International Ed. in English). 43: 5834-6. PMID 15523708 DOI: 10.1002/Anie.200461036 |
0.517 |
|
| 2004 |
Hartig JS, Kool ET. Small circular DNAs for synthesis of the human telomere repeat: varied sizes, structures and telomere-encoding activities. Nucleic Acids Research. 32: e152. PMID 15520461 DOI: 10.1093/Nar/Gnh149 |
0.461 |
|
| 2004 |
Abe H, Kool ET. Destabilizing universal linkers for signal amplification in self-ligating probes for RNA. Journal of the American Chemical Society. 126: 13980-6. PMID 15506759 DOI: 10.1021/Ja046791C |
0.474 |
|
| 2004 |
Kim TW, Kool ET. A set of nonpolar thymidine nucleoside analogues with gradually increasing size. Organic Letters. 6: 3949-52. PMID 15496071 DOI: 10.1021/Ol048487U |
0.318 |
|
| 2004 |
Gao J, Watanabe S, Kool ET. Modified DNA analogues that sense light exposure with color changes. Journal of the American Chemical Society. 126: 12748-9. PMID 15469249 DOI: 10.1021/Ja046910O |
0.574 |
|
| 2004 |
Gao J, Liu H, Kool ET. Expanded-size bases in naturally sized DNA: evaluation of steric effects in Watson-Crick pairing. Journal of the American Chemical Society. 126: 11826-31. PMID 15382917 DOI: 10.1021/Ja048499A |
0.73 |
|
| 2004 |
Liu H, Lynch SR, Kool ET. Solution structure of xDNA: a paired genetic helix with increased diameter. Journal of the American Chemical Society. 126: 6900-5. PMID 15174859 DOI: 10.1021/Ja0497835 |
0.625 |
|
| 2004 |
Miller GP, Kool ET. Versatile 5'-functionalization of oligonucleotides on solid support: amines, azides, thiols, and thioethers via phosphorus chemistry. The Journal of Organic Chemistry. 69: 2404-10. PMID 15049637 DOI: 10.1021/Jo035765E |
0.74 |
|
| 2004 |
Niimi A, Limsirichaikul S, Yoshida S, Iwai S, Masutani C, Hanaoka F, Kool ET, Nishiyama Y, Suzuki M. Palm mutants in DNA polymerases alpha and eta alter DNA replication fidelity and translesion activity. Molecular and Cellular Biology. 24: 2734-46. PMID 15024063 DOI: 10.1128/Mcb.24.7.2734-2746.2004 |
0.472 |
|
| 2004 |
Lai JS, Kool ET. Selective pairing of polyfluorinated DNA bases. Journal of the American Chemical Society. 126: 3040-1. PMID 15012120 DOI: 10.1021/Ja039571S |
0.694 |
|
| 2004 |
Liu H, Gao J, Maynard L, Saito YD, Kool ET. Toward a new genetic system with expanded dimensions: size-expanded analogues of deoxyadenosine and thymidine. Journal of the American Chemical Society. 126: 1102-9. PMID 14746479 DOI: 10.1021/Ja038384R |
0.681 |
|
| 2004 |
Sando S, Abe H, Kool ET. Quenched auto-ligating DNAs: multicolor identification of nucleic acids at single nucleotide resolution. Journal of the American Chemical Society. 126: 1081-7. PMID 14746476 DOI: 10.1021/Ja038665Z |
0.454 |
|
| 2004 |
Maki AS, Kim T, Kool ET. Direct comparison of A- and T-strand minor groove interactions in DNA curvature at A tracts. Biochemistry. 43: 1102-10. PMID 14744156 DOI: 10.1021/Bi035340M |
0.817 |
|
| 2004 |
Smietana M, Johnson RB, Wang QM, Kool ET. Solid-phase synthesis and screening of macrocyclic nucleotide-hybrid compounds targeted to hepatitis C NS5B. Chemistry (Weinheim An Der Bergstrasse, Germany). 10: 173-81. PMID 14695562 DOI: 10.1002/Chem.200305402 |
0.634 |
|
| 2003 |
Kool ET, Miller GP. 5'-Iodination of solid-phase-linked oligodeoxyribonucleotides. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 4.19. PMID 18428909 DOI: 10.1002/0471142700.Nc0419S14 |
0.708 |
|
| 2003 |
Francis AW, Helquist SA, Kool ET, David SS. Probing the requirements for recognition and catalysis in Fpg and MutY with nonpolar adenine isosteres. Journal of the American Chemical Society. 125: 16235-42. PMID 14692765 DOI: 10.1021/Ja0374426 |
0.81 |
|
| 2003 |
Lai JS, Qu J, Kool ET. Fluorinated DNA bases as probes of electrostatic effects in DNA base stacking. Angewandte Chemie (International Ed. in English). 42: 5973-7. PMID 14679546 DOI: 10.1002/Anie.200352531 |
0.7 |
|
| 2003 |
Liu H, Gao J, Lynch SR, Saito YD, Maynard L, Kool ET. A four-base paired genetic helix with expanded size. Science (New York, N.Y.). 302: 868-71. PMID 14593180 DOI: 10.1126/Science.1088334 |
0.725 |
|
| 2003 |
Rausch JW, Qu J, Yi-Brunozzi HY, Kool ET, Le Grice SFJ. Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection Proceedings of the National Academy of Sciences of the United States of America. 100: 11279-11284. PMID 12972638 DOI: 10.1073/Pnas.1932546100 |
0.473 |
|
| 2003 |
Sun L, Zhang K, Zhou L, Hohler P, Kool ET, Yuan F, Wang Z, Taylor JS. Yeast pol eta holds a cis-syn thymine dimer loosely in the active site during elongation opposite the 3'-T of the dimer, but tightly opposite the 5'-T. Biochemistry. 42: 9431-7. PMID 12899630 DOI: 10.1021/Bi0345687 |
0.378 |
|
| 2003 |
Washington MT, Helquist SA, Kool ET, Prakash L, Prakash S. Requirement of Watson-Crick hydrogen bonding for DNA synthesis by yeast DNA polymerase eta. Molecular and Cellular Biology. 23: 5107-12. PMID 12832493 DOI: 10.1128/Mcb.23.14.5107-5112.2003 |
0.846 |
|
| 2003 |
Delaney JC, Henderson PT, Helquist SA, Morales JC, Essigmann JM, Kool ET. High-fidelity in vivo replication of DNA base shape mimics without Watson-Crick hydrogen bonds. Proceedings of the National Academy of Sciences of the United States of America. 100: 4469-73. PMID 12676985 DOI: 10.1073/Pnas.0837277100 |
0.831 |
|
| 2003 |
Maki A, Brownewell FE, Liu D, Kool ET. DNA curvature at A tracts containing a non-polar thymine mimic Nucleic Acids Research. 31: 1059-1066. PMID 12560504 DOI: 10.1093/Nar/Gkg172 |
0.787 |
|
| 2003 |
Begley TJ, Haas BJ, Morales JC, Kool ET, Cunningham RP. Kinetics and binding of the thymine-DNA mismatch glycosylase, Mig-Mth, with mismatch-containing DNA substrates Dna Repair. 2: 107-120. PMID 12509271 DOI: 10.1016/S1568-7864(02)00190-8 |
0.475 |
|
| 2002 |
Sando S, Kool ET. Nonenzymatic DNA ligation in Escherichia coli cells Nucleic Acids Research. Supplement (2001). 121-122. PMID 12903135 |
0.332 |
|
| 2002 |
Smirnov S, Matray TJ, Kool ET, de los Santos C. Integrity of duplex structures without hydrogen bonding: DNA with pyrene paired at abasic sites Nucleic Acids Research. 30: 5561-5569. PMID 12490724 DOI: 10.1093/Nar/Gkf688 |
0.51 |
|
| 2002 |
Morales-Rojas H, Kool ET. A Porphyrin C-Nucleoside Incorporated into DNA Organic Letters. 4: 4377-4380. PMID 12465891 DOI: 10.1021/Ol0267376 |
0.496 |
|
| 2002 |
Lindstrom UM, Chandrasekaran RA, Orbai L, Helquist SA, Miller GP, Oroudjev E, Hansma HG, Kool ET. Artificial human telomeres from DNA nanocircle templates. Proceedings of the National Academy of Sciences of the United States of America. 99: 15953-8. PMID 12444252 DOI: 10.1073/Pnas.252396199 |
0.801 |
|
| 2002 |
Kool ET. Replacing the nucleobases in DNA with designer molecules Accounts of Chemical Research. 35: 936-943. PMID 12437318 DOI: 10.1021/Ar000183U |
0.491 |
|
| 2002 |
Miller GP, Kool ET. A simple method for electrophilic functionalization of DNA. Organic Letters. 4: 3599-601. PMID 12375897 DOI: 10.1021/Ol0264915 |
0.733 |
|
| 2002 |
Smietana M, Kool ET. Efficient and simple solid-phase synthesis of short cyclic oligodeoxynucleotides bearing a phosphorothioate linkage Angewandte Chemie - International Edition. 41: 3704-3707. PMID 12370937 DOI: 10.1002/1521-3773(20021004)41:19<3704::Aid-Anie3704>3.0.Co;2-N |
0.584 |
|
| 2002 |
Lindström UM, Kool ET. An orthogonal oligonucleotide protecting group strategy that enables assembly of repetitive or highly structured DNAs. Nucleic Acids Research. 30: e101. PMID 12364618 DOI: 10.1093/Nar/Gnf100 |
0.448 |
|
| 2002 |
Gao J, Strässler C, Tahmassebi D, Kool ET. Libraries of composite polyfluors built from fluorescent deoxyribosides. Journal of the American Chemical Society. 124: 11590-1. PMID 12296712 DOI: 10.1021/Ja027197A |
0.626 |
|
| 2002 |
Drotschmann K, Hall MC, Shcherbakova PV, Wang H, Erie DA, Brownewell FR, Kool ET, Kunkel TA. DNA binding properties of the yeast Msh2-Msh6 and Mlh1-Pms1 heterodimers. Biological Chemistry. 383: 969-75. PMID 12222686 DOI: 10.1515/Bc.2002.103 |
0.501 |
|
| 2002 |
O'Neill BM, Ratto JE, Good KL, Tahmassebi DC, Helquist SA, Morales JC, Kool ET. A highly effective nonpolar isostere of deoxyguanosine: synthesis, structure, stacking, and base pairing. The Journal of Organic Chemistry. 67: 5869-75. PMID 12182615 DOI: 10.1021/Jo025884E |
0.822 |
|
| 2002 |
Sando S, Kool ET. Imaging of RNA in bacteria with self-ligating quenched probes Journal of the American Chemical Society. 124: 9686-9687. PMID 12175209 DOI: 10.1021/Ja026649G |
0.423 |
|
| 2002 |
Kool ET. Active site tightness and substrate fit in DNA replication Annual Review of Biochemistry. 71: 191-219. PMID 12045095 DOI: 10.1146/Annurev.Biochem.71.110601.135453 |
0.485 |
|
| 2002 |
Sando S, Kool ET. Quencher as leaving group: Efficient detection of DNA-joining reactions Journal of the American Chemical Society. 124: 2096-2097. PMID 11878946 DOI: 10.1021/Ja017328S |
0.432 |
|
| 2002 |
Ohmich T, Maki A, Kool ET. Efficient bacterial transcription of DNA nanocircle vectors with optimized single-stranded promoters Proceedings of the National Academy of Sciences of the United States of America. 99: 54-59. PMID 11752404 DOI: 10.1073/Pnas.012589099 |
0.828 |
|
| 2002 |
Miller GP, Kool ET. A simple method for electrophilic functionalization of DNA Organic Letters. 4: 3599-3601. DOI: 10.1021/ol0264915 |
0.708 |
|
| 2001 |
Diegelman AM, Kool ET. Chemical and enzymatic methods for preparing circular single-stranded DNAs. Current Protocols in Nucleic Acid Chemistry / Edited by Serge L. Beaucage ... [Et Al.]. Unit 5.2. PMID 18428858 DOI: 10.1002/0471142700.Nc0502S00 |
0.847 |
|
| 2001 |
Drotschmann K, Yang W, Brownewell FE, Kool ET, Kunkel TA. Asymmetric recognition of DNA local distortion: Structure-based functional studies of eukaryotic Msh2-Msh6 Journal of Biological Chemistry. 276: 46225-46229. PMID 11641390 DOI: 10.1074/Jbc.C100450200 |
0.499 |
|
| 2001 |
Kool ET. Hydrogen bonding, base stacking, and steric effects in DNA replication Annual Review of Biophysics and Biomolecular Structure. 30: 1-22. PMID 11340050 DOI: 10.1146/Annurev.Biophys.30.1.1 |
0.524 |
|
| 2001 |
Dzantiev L, Alekseyev YO, Morales JC, Kool ET, Romano LJ. Significance of nucleobase shape complementarity and hydrogen bonding in the formation and stability of the closed polymerase - DNA complex Biochemistry. 40: 3215-3221. PMID 11258938 DOI: 10.1021/Bi002569I |
0.409 |
|
| 2001 |
Xu Y, Karalkar NB, Kool ET. Nonenzymatic autoligation in direct three-color detection of RNA and DNA point mutations Nature Biotechnology. 19: 148-152. PMID 11175729 DOI: 10.1038/84414 |
0.512 |
|
| 2001 |
Schofield MJ, Brownewell FE, Nayak S, Du C, Kool ET, Hsieh P. The Phe-X-Glu DNA binding motif of MutS: The role of hydrogen bonding in mismatch recognition Journal of Biological Chemistry. 276: 45505-45508. DOI: 10.1074/Jbc.C100449200 |
0.439 |
|
| 2000 |
Guckian KM, Krugh TR, Kool ET. Solution Structure of a Nonpolar, Non-Hydrogen-Bonded Base Pair Surrogate in DNA. Journal of the American Chemical Society. 122: 6841-6847. PMID 20882115 DOI: 10.1021/Ja994164V |
0.78 |
|
| 2000 |
Morales JC, Kool ET. Varied Molecular Interactions at the Active Sites of Several DNA Polymerases: Nonpolar Nucleoside Isosteres as Probes. Journal of the American Chemical Society. 122: 1001-1007. PMID 20882113 DOI: 10.1021/Ja993464+ |
0.458 |
|
| 2000 |
Guckian KM, Schweitzer BA, Ren RX, Sheils CJ, Tahmassebi DC, Kool ET. Factors Contributing to Aromatic Stacking in Water: Evaluation in the Context of DNA. Journal of the American Chemical Society. 122: 2213-2222. PMID 20865137 DOI: 10.1021/Ja9934854 |
0.781 |
|
| 2000 |
Kool ET. Roles of Watson-Crick and minor groove hydrogen bonds in DNA replication Cold Spring Harbor Symposia On Quantitative Biology. 65: 93-102. PMID 12760024 DOI: 10.1101/Sqb.2000.65.93 |
0.438 |
|
| 2000 |
Kool ET. Synthetically modified DNAs as substrates for polymerases Current Opinion in Chemical Biology. 4: 602-608. PMID 11102863 DOI: 10.1016/S1367-5931(00)00141-1 |
0.495 |
|
| 2000 |
Morales JC, Kool ET. Functional hydrogen-bonding map of the minor groove binding tracks of six DNA polymerases Biochemistry. 39: 12979-12988. PMID 11041863 DOI: 10.1021/Bi001578O |
0.513 |
|
| 2000 |
Kool ET, Morales JC, Guckian KM. Mimicking the Structure and Function of DNA: Insights into DNA Stability and Replication. Angewandte Chemie (International Ed. in English). 39: 990-1009. PMID 10760910 DOI: 10.1002/(Sici)1521-3773(20000317)39:6<990::Aid-Anie990>3.0.Co;2-0 |
0.808 |
|
| 2000 |
Morales JC, Kool ET. Importance of terminal base pair hydrogen-bonding in 3'-end proofreading by the Klenow fragment of DNA polymerase I Biochemistry. 39: 2626-2632. PMID 10704212 DOI: 10.1021/Bi992173A |
0.452 |
|
| 2000 |
Ohmichi T, Kool ET. The virtues of self-binding: High sequence specificity for RNA cleavage by self-processed hammerhead ribozymes Nucleic Acids Research. 28: 776-783. PMID 10637330 DOI: 10.1093/Nar/28.3.776 |
0.365 |
|
| 2000 |
Xu Y, Kool ET. Rapid and selective selenium-mediated autoligation of DNA strands [8] Journal of the American Chemical Society. 122: 9040-9041. DOI: 10.1021/Ja994019H |
0.499 |
|
| 2000 |
Morales JC, Kool ET. Varied molecular interactions at the active sites of several DNA polymerases: Nonpolar nucleoside isosteres as probes Journal of the American Chemical Society. 122: 1001-1007. DOI: 10.1021/ja993464+ |
0.365 |
|
| 2000 |
Kool E, Morales J, Guckian K. Einsichten in Stabilität und Replikation der DNA durch Nachahmung ihrer Struktur und Funktion Angewandte Chemie. 112: 1046-1068. DOI: 10.1002/(Sici)1521-3757(20000317)112:6<1046::Aid-Ange1046>3.0.Co;2-9 |
0.786 |
|
| 1999 |
Morales JC, Kool ET. Minor Groove Interactions between Polymerase and DNA: More Essential to Replication than Watson-Crick Hydrogen Bonds? Journal of the American Chemical Society. 121: 2323-2324. PMID 20852718 DOI: 10.1021/Ja983502+ |
0.533 |
|
| 1999 |
Strässler C, Davis NE, Kool ET. Novel Nucleoside Analogues with Fluorophores Replacing the DNA Base. Helvetica Chimica Acta. 82: 2160-2171. PMID 20016809 DOI: 10.1002/(Sici)1522-2675(19991215)82:12<2160::Aid-Hlca2160>3.0.Co;2-4 |
0.42 |
|
| 1999 |
Rowley PT, Kosciolek BA, Kool ET. Circular antisense oligonucleotides inhibit growth of chronic myeloid leukemia cells. Molecular Medicine (Cambridge, Mass.). 5: 693-700. PMID 10602778 DOI: 10.1007/Bf03401988 |
0.343 |
|
| 1999 |
Hansma HG, Golan R, Hsieh W, Daubendiek SL, Kool ET. Polymerase activities and RNA structures in the atomic force microscope Journal of Structural Biology. 127: 240-247. PMID 10544049 DOI: 10.1006/Jsbi.1999.4170 |
0.531 |
|
| 1999 |
Barsky D, Kool ET, Colvin ME. Interaction and solvation energies of nonpolar DNA base analogues and their role in polymerase insertion fidelity Journal of Biomolecular Structure and Dynamics. 16: 1119-1134. PMID 10447197 DOI: 10.1080/07391102.1999.10508321 |
0.32 |
|
| 1999 |
Diegelman AM, Kool ET. Mimicry of the hepatitis delta virus replication cycle mediated by synthetic circular oligodeoxynucleotides. Chemistry & Biology. 6: 569-76. PMID 10421762 DOI: 10.1016/S1074-5521(99)80089-1 |
0.8 |
|
| 1999 |
Matray TJ, Kool ET. A specific partner for abasic damage in DNA Nature. 399: 704-708. PMID 10385125 DOI: 10.1038/21453 |
0.545 |
|
| 1999 |
Thomson NH, Smith BL, Almqvist N, Schmitt L, Kashlev M, Kool ET, Hansma PK. Oriented, active Escherichia coli RNA polymerase: An atomic force microscope study Biophysical Journal. 76: 1024-1033. PMID 9916034 DOI: 10.1016/S0006-3495(99)77267-X |
0.384 |
|
| 1999 |
Xu Y, Kool ET. High sequence fidelity in a non-enzymatic DNA autoligation reaction. Nucleic Acids Research. 27: 875-81. PMID 9889286 DOI: 10.1093/Nar/27.3.875 |
0.516 |
|
| 1999 |
Kool ET. Replication of non-hydrogen bonded bases by DNA polymerases: a mechanism for steric matching. Biopolymers. 48: 3-17. PMID 9846123 DOI: 10.1002/(Sici)1097-0282(1998)48:1<3::Aid-Bip2>3.0.Co;2-7 |
0.482 |
|
| 1999 |
Frieden M, Pedroso E, Kool ET. Tightening the belt on polymerases: Evaluating the physical constraints on enzyme substrate size Angewandte Chemie - International Edition. 38: 3654-3657. DOI: 10.1002/(Sici)1521-3773(19991216)38:24<3654::Aid-Anie3654>3.0.Co;2-S |
0.535 |
|
| 1999 |
Frieden M, Pedroso E, Kool E. Kleine DNA-Ringe als Substrate für Polymerasen: eine Abschätzung der Anforderungen an die Größe der Enzymsubstrate Angewandte Chemie. 111: 3870-3874. DOI: 10.1002/(Sici)1521-3757(19991216)111:24<3870::Aid-Ange3870>3.0.Co;2-O |
0.39 |
|
| 1998 |
Guckian KM, Morales JC, Kool ET. Structure and Base Pairing Properties of a Replicable Nonpolar Isostere for Deoxyadenosine. The Journal of Organic Chemistry. 63: 9652-9656. PMID 20852720 DOI: 10.1021/Jo9805100 |
0.798 |
|
| 1998 |
Kool ET. Recognition of DNA, RNA, and Proteins by Circular Oligonucleotides. Accounts of Chemical Research. 31: 502-510. PMID 19946615 DOI: 10.1021/Ar9602462 |
0.53 |
|
| 1998 |
Diegelman AM, Daubendiek SL, Kool ET. Generation of RNA ladders by rolling circle transcription of small circular oligodeoxyribonucleotides. Biotechniques. 25: 754-8. PMID 9821573 DOI: 10.2144/98255Bm01 |
0.786 |
|
| 1998 |
Guckian KM, Krugh TR, Kool ET. Solution structure of a DNA duplex containing a replicable difluorotoluene-adenine pair. Nature Structural Biology. 5: 954-9. PMID 9808039 DOI: 10.1038/2930 |
0.778 |
|
| 1998 |
Morales JC, Kool ET. Efficient replication between non-hydrogen-bonded nucleoside shape analogs. Nature Structural Biology. 5: 950-4. PMID 9808038 DOI: 10.1038/2925 |
0.407 |
|
| 1998 |
Paris PL, Langenhan JM, Kool ET. Probing DNA sequences in solution with a monomer-excimer fluorescence color change. Nucleic Acids Research. 26: 3789-93. PMID 9685497 DOI: 10.1093/Nar/26.16.3789 |
0.38 |
|
| 1998 |
Diegelman AM, Kool ET. Generation of circular RNAs and trans-cleaving catalytic RNAs by rolling transcription of circular DNA oligonucleotides encoding hairpin ribozymes. Nucleic Acids Research. 26: 3235-41. PMID 9628924 DOI: 10.1093/Nar/26.13.3235 |
0.818 |
|
| 1998 |
Xu Y, Kool ET. Chemical and enzymatic properties of bridging 5'-S-phosphorothioester linkages in DNA. Nucleic Acids Research. 26: 3159-64. PMID 9628913 DOI: 10.1093/Nar/26.13.3159 |
0.521 |
|
| 1998 |
Ryan K, Kool ET. Triplex-directed self-assembly of an artificial sliding clamp on duplex DNA. Chemistry & Biology. 5: 59-67. PMID 9495829 DOI: 10.1016/S1074-5521(98)90140-5 |
0.633 |
|
| 1998 |
Sun W, Hattman S, Kool E. Interaction of the bacteriophage Mu transcriptional activator protein, C, with its target site in the mom promoter. Journal of Molecular Biology. 273: 765-74. PMID 9367769 DOI: 10.1006/Jmbi.1997.1349 |
0.358 |
|
| 1997 |
Guckian KM, Kool ET. Highly Precise Shape Mimicry by a Difluorotoluene Deoxynucleoside, a Replication-Competent Substitute for Thymidine. Angewandte Chemie (International Ed. in English). 36: 2825-2828. PMID 20882112 DOI: 10.1002/Anie.199728251 |
0.782 |
|
| 1997 |
Chaudhuri NC, Ren RX, Kool ET. C-Nucleosides Derived from Simple Aromatic Hydrocarbons. Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry. 4: 341-347. PMID 20336193 DOI: 10.1055/S-1997-788 |
0.478 |
|
| 1997 |
Liu D, Moran S, Kool ET. Bi-stranded, multisite replication of a base pair between difluorotoluene and adenine: Confirmation by 'inverse' sequencing Chemistry and Biology. 4: 919-926. PMID 9427657 DOI: 10.1016/S1074-5521(97)90300-8 |
0.477 |
|
| 1997 |
Moran S, Ren RXF, Kool ET. A thymidine triphosphate shape analog lacking Watson-Crick pairing ability is replicated with high sequence selectivity Proceedings of the National Academy of Sciences of the United States of America. 94: 10506-10511. PMID 9380669 DOI: 10.1073/Pnas.94.20.10506 |
0.453 |
|
| 1997 |
Wang S, Xu Y, Kool ET. Recognition of RNA by triplex formation: divergent effects of pyrimidine C-5 methylation. Bioorganic & Medicinal Chemistry. 5: 1043-50. PMID 9222497 DOI: 10.1016/S0968-0896(97)00059-X |
0.449 |
|
| 1997 |
Daubendiek SL, Kool ET. Generation of catalytic RNAs by rolling transcription of synthetic DNA nanocircles. Nature Biotechnology. 15: 273-7. PMID 9062929 DOI: 10.1038/Nbt0397-273 |
0.459 |
|
| 1997 |
Kasas S, Thomson NH, Smith BL, Hansma HG, Zhu X, Guthold M, Bustamante C, Kool ET, Kashlev M, Hansma PK. Escherichia coli RNA polymerase activity observed using atomic force microscopy Biochemistry. 36: 461-468. PMID 9012661 DOI: 10.1021/Bi9624402 |
0.453 |
|
| 1997 |
Gupta V, Kool ET. A self-cleaving DNA nucleoside Chemical Communications. 1425-1426. DOI: 10.1039/A700626H |
0.466 |
|
| 1997 |
Moran S, Ren RXF, Rumney S, Kool ET. Difluorotoluene, a nonpolar isostere for thymine, codes specifically and efficiently for adenine in DNA replication Journal of the American Chemical Society. 119: 2056-2057. DOI: 10.1021/Ja963718G |
0.553 |
|
| 1997 |
Guckian KM, Kool ET. Hochpräzise Gestaltnachahmung durch ein Difluortoluol-Desoxynucleosid — ein replikationsfähiger Ersatz für Thymidin Angewandte Chemie. 109: 2942-2945. DOI: 10.1002/Ange.19971092440 |
0.697 |
|
| 1996 |
Guckian KM, Schweitzer BA, Ren RX, Sheils CJ, Paris PL, Tahmassebi DC, Kool ET. Experimental Measurement of Aromatic Stacking Affinities in the Context of Duplex DNA. Journal of the American Chemical Society. 118: 8182-8183. PMID 20882117 DOI: 10.1021/Ja961733F |
0.798 |
|
| 1996 |
Ren XF, Schweitzer BA, Sheils CJ, Kool ET. Formation of Stable DNA Loops by Incorporation of Nonpolar, Non-Hydrogen-Bonding Nucleoside Isosteres. Angewandte Chemie (International Ed. in English). 35: 743-746. PMID 20882114 DOI: 10.1002/Anie.199607431 |
0.467 |
|
| 1996 |
Ren RX, Chaudhuri NC, Paris PL, Rumney S, Kool ET. Naphthalene, Phenanthrene, and Pyrene as DNA Base Analogues: Synthesis, Structure, and Fluorescence in DNA. Journal of the American Chemical Society. 118: 7671-7678. PMID 20865136 DOI: 10.1021/Ja9612763 |
0.462 |
|
| 1996 |
Liu D, Daubendiek SL, Zillman MA, Ryan K, Kool ET. Rolling Circle DNA Synthesis: Small Circular Oligonucleotides as Efficient Templates for DNA Polymerases. Journal of the American Chemical Society. 118: 1587-1594. PMID 20830216 DOI: 10.1021/Ja952786K |
0.65 |
|
| 1996 |
Kool ET. Circular oligonucleotides: new concepts in oligonucleotide design. Annual Review of Biophysics and Biomolecular Structure. 25: 1-28. PMID 8800462 DOI: 10.1146/Annurev.Bb.25.060196.000245 |
0.528 |
|
| 1996 |
Moran S, Ren RX, Sheils CJ, Rumney S, Kool ET. Non-hydrogen bonding 'terminator' nucleosides increase the 3'-end homogeneity of enzymatic RNA and DNA synthesis. Nucleic Acids Research. 24: 2044-52. PMID 8668534 DOI: 10.1093/Nar/24.11.2044 |
0.541 |
|
| 1996 |
Schweitzer BA, Kool ET. Hydrophobic, Non-Hydrogen-Bonding Bases and Base Pairs in DNAJ.Am.Chem.Soc.1995,117, 1863−1872 Journal of the American Chemical Society. 118: 931-931. DOI: 10.1021/Ja955034Z |
0.301 |
|
| 1996 |
Kool ET. Topological modification of oligonucleotides for potential inhibition of gene expression Perspectives in Drug Discovery and Design. 4: 61-75. DOI: 10.1007/Bf02172109 |
0.513 |
|
| 1996 |
Ren X, Schweitzer BA, Sheils CJ, Kool ET. Stabile DNA-Schleifen durch Einbau unpolarer und keine Wasserstoffbrücken bildender Nucleosid-Isostere Angewandte Chemie. 108: 834-837. DOI: 10.1002/Ange.19961080723 |
0.47 |
|
| 1995 |
Daubendiek SL, Ryan K, Kool ET. Rolling-Circle RNA Synthesis: Circular Oligonucleotides as Efficient Substrates for T7 RNA Polymerase. Journal of the American Chemical Society. 117: 7818-7819. PMID 27524830 DOI: 10.1021/Ja00134A032 |
0.619 |
|
| 1995 |
Chaudhuri NC, Kool ET. Very High Affinity DNA Recognition by Bicyclic and Cross-Linked Oligonucleotides. Journal of the American Chemical Society. 117: 10434-10442. PMID 20882118 DOI: 10.1021/Ja00147A004 |
0.529 |
|
| 1995 |
Rumney S, Kool ET. Structural Optimization of Non-Nucleotide Loop Replacements for Duplex and Triplex DNAs. Journal of the American Chemical Society. 117: 5635-5646. PMID 20871801 DOI: 10.1021/Ja00126A004 |
0.467 |
|
| 1995 |
Rubin E, Rumney S, Wang S, Kool ET. Convergent DNA synthesis: a non-enzymatic dimerization approach to circular oligodeoxynucleotides. Nucleic Acids Research. 23: 3547-53. PMID 7567468 DOI: 10.1093/Nar/23.17.3547 |
0.491 |
|
| 1995 |
Wang S, Friedman AE, Kool ET. Origins of high sequence selectivity: a stopped-flow kinetics study of DNA/RNA hybridization by duplex- and triplex-forming oligonucleotides. Biochemistry. 34: 9774-84. PMID 7542923 DOI: 10.1021/Bi00030A015 |
0.498 |
|
| 1995 |
Wang S, Kool ET. Relative stabilities of triple helices composed of combinations of DNA, RNA and 2'-O-methyl-RNA backbones: chimeric circular oligonucleotides as probes. Nucleic Acids Research. 23: 1157-64. PMID 7537873 DOI: 10.1093/Nar/23.7.1157 |
0.506 |
|
| 1995 |
Wang S, Kool ET. Origins of the large differences in stability of DNA and RNA helices: C-5 methyl and 2'-hydroxyl effects. Biochemistry. 34: 4125-32. PMID 7535100 DOI: 10.1021/Bi00012A031 |
0.412 |
|
| 1994 |
D'Souza DJ, Kool ET. Solvent, pH, and Ionic Effects on the Binding of Single-Stranded DNA by Circular Oligodeoxynucleotides. Bioorganic & Medicinal Chemistry Letters. 4: 965-970. PMID 27840561 DOI: 10.1016/S0960-894X(01)80664-8 |
0.473 |
|
| 1994 |
Wang S, Kool ET. Recognition of Single-Stranded Nucleic Acids by Triplex Formation: The Binding of Pyrimidine-Rich Sequences. Journal of the American Chemical Society. 116: 8857-8858. PMID 20882109 DOI: 10.1021/Ja00098A075 |
0.459 |
|
| 1994 |
Rubin E, Kool ET. Strong, Specific Binding of Six Different DNA Sequences by a Single Conformation-Switching DNA Macrocycle. Angewandte Chemie (International Ed. in English). 33: 1004-1007. PMID 20808717 DOI: 10.1002/Anie.199410041 |
0.385 |
|
| 1994 |
Booher MA, Wang S, Kool ET. Base pairing and steric interactions between pyrimidine strand bridging loops and the purine strand in DNA pyrimidine.purine.pyrimidine triplexes. Biochemistry. 33: 4645-51. PMID 8161521 DOI: 10.1021/Bi00181A027 |
0.433 |
|
| 1994 |
Wang S, Booher MA, Kool ET. Stabilities of nucleotide loops bridging the pyrimidine strands in DNA pyrimidine.purine.pyrimidine triplexes: special stability of the CTTTG loop. Biochemistry. 33: 4639-44. PMID 8161520 DOI: 10.1021/Bi00181A026 |
0.388 |
|
| 1994 |
Wang S, Kool ET. Circular RNA oligonucleotides. Synthesis, nucleic acid binding properties, and a comparison with circular DNAs. Nucleic Acids Research. 22: 2326-33. PMID 7518582 DOI: 10.1093/Nar/22.12.2326 |
0.493 |
|
| 1994 |
Rubin E, Kool ET. Starke, spezifische Bindung sechs verschiedener DNA-Sequenzen an einen konformativ flexiblen DNA-Makrocyclus Angewandte Chemie. 106: 1057-1059. DOI: 10.1002/Ange.19941060929 |
0.482 |
|
| 1993 |
Rubin E, McKee TL, Kool ET. Binding of Two Different DNA Sequences by Conformational Switching. Journal of the American Chemical Society. 115: 360-361. PMID 20808716 DOI: 10.1021/Ja00054A060 |
0.381 |
|
| 1993 |
Perkins TA, Goodman JL, Kool ET. Accelerated displacement of duplex DNA strands by a synthetic circular oligodeoxynucleotide Journal of the Chemical Society, Chemical Communications. 215-216. DOI: 10.1039/C39930000215 |
0.518 |
|
| 1992 |
Rumney S, Kool ET. DNA Recognition by Hybrid Oligoether-Oligodeoxynucleotide Macrocycles. Angewandte Chemie (International Ed. in English). 31: 1617-1619. PMID 27867314 DOI: 10.1002/Anie.199216171 |
0.475 |
|
| 1992 |
Prakash G, Kool ET. Structural Effects in the Recognition of DNA by Circular Oligonucleotides. Journal of the American Chemical Society. 114: 3523-3527. PMID 27867206 DOI: 10.1021/Ja00035A056 |
0.421 |
|
| 1992 |
D'Souza DJ, Kool ET. Strong binding of single-stranded DNA by stem-loop oligonucleotides. Journal of Biomolecular Structure & Dynamics. 10: 141-52. PMID 1418737 DOI: 10.1080/07391102.1992.10508634 |
0.432 |
|
| 1992 |
Kool ET. Molecular recognition by circular oligonucleotides: increasing the selectivity of DNA binding. [Erratum to document cited in CA115(9):92800e] Journal of the American Chemical Society. 114: 1929-1929. DOI: 10.1021/Ja00031A085 |
0.375 |
|
| 1992 |
Rumney S, Kool ET. DNA-Erkennung durch makrocyclische Oligoether-Oligodesoxynucleotid-Hybridverbindungen Angewandte Chemie. 104: 1686-1689. DOI: 10.1002/Ange.19921041240 |
0.483 |
|
| 1991 |
Prakash G, Kool ET. Molecular Recognition by Circular Oligonucleotides. Strong Binding of Single-stranded DNA and RNA. Journal of the Chemical Society. Chemical Communications. 1991: 1161-1163. PMID 27867221 DOI: 10.1039/C39910001161 |
0.521 |
|
| 1991 |
Prakash G, Kool ET. Molecular recognition by circular oligonucleotides. Strong binding of single-stranded DNA and RNA Journal of the Chemical Society, Chemical Communications. 1161-1163. DOI: 10.1039/C39910001161 |
0.426 |
|
| 1991 |
Kool ET. Molecular recognition by circular oligonucleotides: increasing the selectivity of DNA binding Journal of the American Chemical Society. 113: 6265-6266. DOI: 10.1021/Ja00016A050 |
0.487 |
|
| 1988 |
Kool ET, Breslow R. Dichotomous salt effects in the hydrophobic acceleration of the benzoin condensation Journal of the American Chemical Society. 110: 1596-1597. DOI: 10.1021/Ja00213A036 |
0.452 |
|
| 1988 |
Breslow R, Kool E. A γ-cyclodextrin thiazolium salt holoenzyme mimic for the benzoin condensation Tetrahedron Letters. 29: 1635-1638. DOI: 10.1016/S0040-4039(00)82004-3 |
0.369 |
|
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