Year |
Citation |
Score |
2020 |
O'Kane GM, Grünwald BT, Jang GH, Masoomian M, Picardo S, Grant RC, Denroche RE, Zhang A, Wang Y, Lam B, Krzyzanowski PM, Lungu IM, Bartlett JMS, Peralta M, Vyas F, ... Khokha R, et al. GATA6 expression distinguishes classical and basal-like subtypes in advanced pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32156747 DOI: 10.1158/1078-0432.Ccr-19-3724 |
0.304 |
|
2020 |
Romero JM, Grünwald BT, Jang GH, Bavi PP, Jhaveri A, Masoomian M, Fischer SE, Zhang A, Denroche RE, Lungu IM, De Luca A, Bartlett JMS, Xu J, Li N, Dhaliwal S, ... ... Khokha R, et al. A four-chemokine signature is associated with a T cell-inflamed phenotype in primary and metastatic pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31964786 DOI: 10.1158/1078-0432.Ccr-19-2803 |
0.323 |
|
2020 |
Jawhar W, Waterhouse P, Khokha R, Ishii T, Turcotte R, Jabado N, Garzia L. Abstract A64: Functional genomics of metastatic Ewing sarcoma Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-A64 |
0.374 |
|
2019 |
Shehata M, Kim H, Vellanki R, Waterhouse PD, Mahendralingam M, Casey AE, Koritzinsky M, Khokha R. Identifying the murine mammary cell target of metformin exposure. Communications Biology. 2: 192. PMID 31925073 DOI: 10.1038/s42003-019-0439-x |
0.321 |
|
2019 |
Saw S, Weiss A, Khokha R, Waterhouse PD. Metalloproteases: On the Watch in the Hematopoietic Niche. Trends in Immunology. PMID 31645297 DOI: 10.1016/J.It.2019.09.006 |
0.403 |
|
2019 |
Saw S, Aiken A, Fang H, McKee TD, Bregant S, Sanchez O, Chen Y, Weiss A, Dickson BC, Czarny B, Sinha A, Fosang A, Dive V, Waterhouse PD, Kislinger T, ... Khokha R, et al. Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth. The Journal of Cell Biology. PMID 31371388 DOI: 10.1083/Jcb.201906059 |
0.329 |
|
2019 |
Tharmapalan P, Mahendralingam M, Berman HK, Khokha R. Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention. The Embo Journal. 38: e100852. PMID 31267556 DOI: 10.15252/Embj.2018100852 |
0.439 |
|
2019 |
Shehata M, Kim H, Vellanki R, Waterhouse PD, Mahendralingam M, Casey AE, Koritzinsky M, Khokha R. Identifying the murine mammary cell target of metformin exposure. Communications Biology. 2: 192. PMID 31123716 DOI: 10.1038/s42003-019-0439-x |
0.321 |
|
2019 |
Joshi PA, Waterhouse PD, Kasaian K, Fang H, Gulyaeva O, Sul HS, Boutros PC, Khokha R. PDGFRα stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland. Nature Communications. 10: 1760. PMID 30988300 DOI: 10.1038/S41467-019-09748-Z |
0.792 |
|
2018 |
Shehata M, Waterhouse PD, Casey AE, Fang H, Hazelwood L, Khokha R. Proliferative heterogeneity of murine epithelial cells in the adult mammary gland. Communications Biology. 1: 111. PMID 30271991 DOI: 10.1038/s42003-018-0114-7 |
0.341 |
|
2018 |
Li L, Guturi KKN, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, et al. Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. The Journal of Clinical Investigation. PMID 30222135 DOI: 10.1172/Jci120401 |
0.428 |
|
2018 |
Chen Y, Aiken A, Saw S, Weiss A, Fang H, Khokha R. TIMP loss activates metalloproteinase-TNFα-DKK1 axis to compromise Wnt signaling and bone mass. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 30216540 DOI: 10.1002/Jbmr.3585 |
0.33 |
|
2018 |
Shao YW, Wood GA, Lu J, Tang QL, Liu J, Molyneux S, Chen Y, Fang H, Adissu H, McKee T, Waterhouse P, Khokha R. Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma. Oncogene. PMID 30093633 DOI: 10.1038/S41388-018-0444-4 |
0.332 |
|
2018 |
Casey AE, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, Cruickshank J, Shehata M, Drysdale E, Fang H, Kim H, Isserlin R, Bailey S, Medina T, Deblois G, ... ... Khokha R, et al. Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. The Journal of Cell Biology. PMID 29921600 DOI: 10.1083/Jcb.201804042 |
0.442 |
|
2018 |
Tang Q, Lu J, Zou C, Shao Y, Chen Y, Narala S, Fang H, Xu H, Wang J, Shen J, Khokha R. CDH4 is a novel determinant of osteosarcoma tumorigenesis and metastasis. Oncogene. PMID 29610525 DOI: 10.1038/S41388-018-0231-2 |
0.363 |
|
2017 |
Shimoda M, Khokha R. Metalloproteinases in extracellular vesicles. Biochimica Et Biophysica Acta. PMID 28578911 DOI: 10.1016/J.Bbamcr.2017.05.027 |
0.41 |
|
2017 |
Voura EB, Montalvo MJ, Dela Roca KT, Fisher JM, Defamie V, Narala SR, Khokha R, Mulligan ME, Evans CA. Planarians as models of cadmium-induced neoplasia provide measurable benchmarks for mechanistic studies. Ecotoxicology and Environmental Safety. 142: 544-554. PMID 28482323 DOI: 10.1016/J.Ecoenv.2017.04.044 |
0.401 |
|
2016 |
Jackson HW, Defamie V, Waterhouse P, Khokha R. TIMPs: versatile extracellular regulators in cancer. Nature Reviews. Cancer. PMID 27932800 DOI: 10.1038/Nrc.2016.115 |
0.408 |
|
2016 |
Shimoda M, Jackson HW, Khokha R. Tumor suppression by stromal TIMPs. Molecular & Cellular Oncology. 3: e975082. PMID 27314104 DOI: 10.4161/23723556.2014.975082 |
0.36 |
|
2016 |
Sigl V, Owusu-Boaitey K, Joshi PA, Kavirayani A, Wirnsberger G, Novatchkova M, Kozieradzki I, Schramek D, Edokobi N, Hersl J, Sampson A, Odai-Afotey A, Lazaro C, Gonzalez-Suarez E, Pujana MA, ... ... Khokha R, et al. RANKL/RANK control Brca1 mutation-driven mammary tumors. Cell Research. PMID 27241552 DOI: 10.1038/Cr.2016.69 |
0.773 |
|
2015 |
Shiah YJ, Tharmapalan P, Casey AE, Joshi PA, McKee TD, Jackson HW, Beristain AG, Chan-Seng-Yue MA, Bader GD, Lydon JP, Waterhouse PD, Boutros PC, Khokha R. A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland. Stem Cell Reports. 4: 313-322. PMID 28447939 DOI: 10.1016/J.Stemcr.2015.01.011 |
0.799 |
|
2015 |
Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R. RANKL blockade prevents and treats aggressive osteosarcomas. Science Translational Medicine. 7: 317ra197. PMID 26659571 DOI: 10.1126/Scitranslmed.Aad0295 |
0.325 |
|
2015 |
Joshi PA, Goodwin PJ, Khokha R. Progesterone and Synthetic Progestin Controversies-Reply. Jama Oncology. 1: 987-8. PMID 26448288 DOI: 10.1001/Jamaoncol.2015.2294 |
0.73 |
|
2015 |
Adissu HA, McKerlie C, Di Grappa M, Waterhouse P, Xu Q, Fang H, Khokha R, Wood GA. Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer. The Prostate. PMID 26332574 DOI: 10.1002/Pros.23056 |
0.35 |
|
2015 |
Joshi PA, Goodwin PJ, Khokha R. Progesterone Exposure and Breast Cancer Risk: Understanding the Biological Roots. Jama Oncology. 1: 283-5. PMID 26181171 DOI: 10.1001/Jamaoncol.2015.0512 |
0.752 |
|
2015 |
Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C, Khokha R. RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 5: 31-44. PMID 26095608 DOI: 10.1016/J.Stemcr.2015.05.012 |
0.793 |
|
2015 |
Jackson HW, Hojilla CV, Weiss A, Sanchez OH, Wood GA, Khokha R. Timp3 deficient mice show resistance to developing breast cancer. Plos One. 10: e0120107. PMID 25807548 DOI: 10.1371/Journal.Pone.0120107 |
0.426 |
|
2015 |
Jackson HW, Waterhouse P, Sinha A, Kislinger T, Berman HK, Khokha R. Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice. Nature Cell Biology. 17: 217-27. PMID 25706237 DOI: 10.1038/Ncb3118 |
0.38 |
|
2015 |
Shiah YJ, Tharmapalan P, Casey AE, Joshi PA, McKee TD, Jackson HW, Beristain AG, Chan-Seng-Yue MA, Bader GD, Lydon JP, Waterhouse PD, Boutros PC, Khokha R. A progesterone-CXCR4 axis controls mammary progenitor cell fate in the adult gland. Stem Cell Reports. 4: 313-22. PMID 25702641 DOI: 10.1016/j.stemcr.2015.01.011 |
0.794 |
|
2015 |
Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brüstle A, ... ... Khokha R, et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell. 27: 211-22. PMID 25620030 DOI: 10.1016/J.Ccell.2014.11.019 |
0.35 |
|
2015 |
Beristain AG, Molyneux SD, Joshi PA, Pomroy NC, Di Grappa MA, Chang MC, Kirschner LS, Privé GG, Pujana MA, Khokha R. PKA signaling drives mammary tumorigenesis through Src. Oncogene. 34: 1160-73. PMID 24662820 DOI: 10.1038/Onc.2014.41 |
0.789 |
|
2014 |
Defamie V, Sanchez O, Murthy A, Khokha R. TIMP3 controls cell fate to confer hepatocellular carcinoma resistance. Oncogene. PMID 25347747 DOI: 10.1038/Onc.2014.339 |
0.392 |
|
2014 |
Shimoda M, Principe S, Jackson HW, Luga V, Fang H, Molyneux SD, Shao YW, Aiken A, Waterhouse PD, Karamboulas C, Hess FM, Ohtsuka T, Okada Y, Ailles L, Ludwig A, ... ... Khokha R, et al. Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Nature Cell Biology. 16: 889-901. PMID 25150980 DOI: 10.1038/Ncb3021 |
0.472 |
|
2014 |
Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvák Z, ... ... Khokha R, et al. Human somatic cell mutagenesis creates genetically tractable sarcomas. Nature Genetics. 46: 964-72. PMID 25129143 DOI: 10.1038/Ng.3065 |
0.343 |
|
2014 |
Penfornis P, Cai DZ, Harris MR, Walker R, Licini D, Fernandes JD, Orr G, Koganti T, Hicks C, Induru S, Meyer MS, Khokha R, Barr J, Pochampally RR. High CD49f expression is associated with osteosarcoma tumor progression: a study using patient-derived primary cell cultures. Cancer Medicine. 3: 796-811. PMID 24802970 DOI: 10.1002/Cam4.249 |
0.406 |
|
2014 |
Alexander CM, Joshi PA, Khokha R. Fully interlocking: a story of teamwork among breast epithelial cells. Developmental Cell. 28: 114-5. PMID 24480641 DOI: 10.1016/J.Devcel.2014.01.011 |
0.769 |
|
2013 |
Wei LZ, Xu Y, Nelles EM, Furlonger C, Wang JC, Di Grappa MA, Khokha R, Medin JA, Paige CJ. Localized interleukin-12 delivery for immunotherapy of solid tumours. Journal of Cellular and Molecular Medicine. 17: 1465-74. PMID 24251770 DOI: 10.1111/Jcmm.12121 |
0.309 |
|
2013 |
Voura EB, English JL, Yu HY, Ho AT, Subarsky P, Hill RP, Hojilla CV, Khokha R. Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types. Plos One. 8: e78413. PMID 24194929 DOI: 10.1371/Journal.Pone.0078413 |
0.401 |
|
2013 |
Khokha R, Murthy A, Weiss A. Metalloproteinases and their natural inhibitors in inflammation and immunity. Nature Reviews. Immunology. 13: 649-65. PMID 23969736 DOI: 10.1038/Nri3499 |
0.377 |
|
2013 |
Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, ... ... Khokha R, et al. BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. The Journal of Experimental Medicine. 210: 1529-44. PMID 23857982 DOI: 10.1084/Jem.20121337 |
0.77 |
|
2013 |
Shimoda M, Khokha R. Proteolytic factors in exosomes. Proteomics. 13: 1624-36. PMID 23526769 DOI: 10.1002/Pmic.201200458 |
0.395 |
|
2013 |
Lee HJ, Gallego-Ortega D, Ledger A, Schramek D, Joshi P, Szwarc MM, Cho C, Lydon JP, Khokha R, Penninger JM, Ormandy CJ. Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development (Cambridge, England). 140: 1397-401. PMID 23462470 DOI: 10.1242/Dev.088948 |
0.792 |
|
2013 |
Hewing NJ, Weskamp G, Vermaat J, Farage E, Glomski K, Swendeman S, Chan RV, Chiang MF, Khokha R, Anand-Apte B, Blobel CP. Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice. Investigative Ophthalmology & Visual Science. 54: 864-70. PMID 23299479 DOI: 10.1167/Iovs.12-10954 |
0.33 |
|
2013 |
Shiah Y, Joshi PA, Beristain AG, Chan-Seng-Yue M, Boutros PC, Khokha R. Abstract B023: Identifying molecular programs of progesterone-driven mammary stem cell expansion Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-B023 |
0.804 |
|
2012 |
Joshi PA, Di Grappa MA, Khokha R. Active allies: hormones, stem cells and the niche in adult mammopoiesis. Trends in Endocrinology and Metabolism: Tem. 23: 299-309. PMID 22613704 DOI: 10.1016/J.Tem.2012.04.002 |
0.784 |
|
2012 |
Joshi PA, Khokha R. The mammary stem cell conundrum: is it unipotent or multipotent? Breast Cancer Research : Bcr. 14: 305. PMID 22424095 DOI: 10.1186/Bcr3123 |
0.784 |
|
2012 |
Beristain AG, Narala SR, Di Grappa MA, Khokha R. Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells. Journal of Cell Science. 125: 943-55. PMID 22421365 DOI: 10.1242/Jcs.094029 |
0.458 |
|
2012 |
Murthy A, Shao YW, Defamie V, Wedeles C, Smookler D, Khokha R. Stromal TIMP3 regulates liver lymphocyte populations and provides protection against Th1 T cell-driven autoimmune hepatitis. Journal of Immunology (Baltimore, Md. : 1950). 188: 2876-83. PMID 22323541 DOI: 10.4049/Jimmunol.1102199 |
0.392 |
|
2012 |
Murthy A, Shao YW, Narala SR, Molyneux SD, Zúñiga-Pflücker JC, Khokha R. Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis. Immunity. 36: 105-19. PMID 22284418 DOI: 10.1016/J.Immuni.2012.01.005 |
0.351 |
|
2012 |
McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, et al. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (New York, N.Y.). 335: 229-32. PMID 22246778 DOI: 10.1126/Science.1214448 |
0.326 |
|
2012 |
Sanchezsweatman O, Soares F, Whaley M, Khokha R, Orr F, Singh G. Differential regulation of matrix metalloproteinases in human cancer cells by exogenous factors. International Journal of Oncology. 11: 1321-6. PMID 21528341 DOI: 10.3892/Ijo.11.6.1321 |
0.433 |
|
2011 |
Hojilla CV, Jackson HW, Khokha R. TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence. Plos One. 6: e26718. PMID 22053204 DOI: 10.1371/Journal.Pone.0026718 |
0.433 |
|
2011 |
Ebrahem Q, Qi JH, Sugimoto M, Ali M, Sears JE, Cutler A, Khokha R, Vasanji A, Anand-Apte B. Increased neovascularization in mice lacking tissue inhibitor of metalloproteinases-3. Investigative Ophthalmology & Visual Science. 52: 6117-23. PMID 21282576 DOI: 10.1167/Iovs.10-5899 |
0.373 |
|
2011 |
Khokha R, Werb Z. Mammary gland reprogramming: metalloproteinases couple form with function. Cold Spring Harbor Perspectives in Biology. 3. PMID 21106646 DOI: 10.1101/Cshperspect.A004333 |
0.352 |
|
2010 |
Le Gall SM, Maretzky T, Issuree PD, Niu XD, Reiss K, Saftig P, Khokha R, Lundell D, Blobel CP. ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site. Journal of Cell Science. 123: 3913-22. PMID 20980382 DOI: 10.1242/Jcs.069997 |
0.35 |
|
2010 |
Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 468: 98-102. PMID 20881962 DOI: 10.1038/Nature09387 |
0.789 |
|
2010 |
Nakajima H, Ito M, Smookler DS, Shibata F, Fukuchi Y, Morikawa Y, Ikeda Y, Arai F, Suda T, Khokha R, Kitamura T. TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool. Blood. 116: 4474-82. PMID 20798233 DOI: 10.1182/Blood-2010-01-266528 |
0.461 |
|
2010 |
Molyneux SD, Di Grappa MA, Beristain AG, McKee TD, Wai DH, Paderova J, Kashyap M, Hu P, Maiuri T, Narala SR, Stambolic V, Squire J, Penninger J, Sanchez O, Triche TJ, ... ... Khokha R, et al. Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. The Journal of Clinical Investigation. 120: 3310-25. PMID 20697156 DOI: 10.1172/Jci42391 |
0.346 |
|
2010 |
Murthy A, Defamie V, Smookler DS, Di Grappa MA, Horiuchi K, Federici M, Sibilia M, Blobel CP, Khokha R. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. The Journal of Clinical Investigation. 120: 2731-44. PMID 20628198 DOI: 10.1172/Jci42686 |
0.383 |
|
2010 |
Koskivirta I, Kassiri Z, Rahkonen O, Kiviranta R, Oudit GY, McKee TD, Kytö V, Saraste A, Jokinen E, Liu PP, Vuorio E, Khokha R. Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload. The Journal of Biological Chemistry. 285: 24487-93. PMID 20516072 DOI: 10.1074/Jbc.M110.136820 |
0.342 |
|
2010 |
Joshi PA, Jackson HW, Beristain AG, Di Grappa MA, Mote PA, Clarke CL, Stingl J, Waterhouse PD, Khokha R. Progesterone induces adult mammary stem cell expansion. Nature. 465: 803-7. PMID 20445538 DOI: 10.1038/Nature09091 |
0.807 |
|
2010 |
Gill SE, Huizar I, Bench EM, Sussman SW, Wang Y, Khokha R, Parks WC. Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury American Journal of Pathology. 176: 64-73. PMID 20008147 DOI: 10.2353/Ajpath.2010.090158 |
0.323 |
|
2010 |
Fiorentino L, Vivanti A, Cavalera M, Marzano V, Ronci M, Fabrizi M, Menini S, Pugliese G, Menghini R, Khokha R, Lauro R, Urbani A, Federici M. Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice. Hepatology (Baltimore, Md.). 51: 103-10. PMID 19877183 DOI: 10.1002/Hep.23250 |
0.32 |
|
2010 |
Aiken A, Khokha R. Unraveling metalloproteinase function in skeletal biology and disease using genetically altered mice. Biochimica Et Biophysica Acta. 1803: 121-32. PMID 19616584 DOI: 10.1016/J.Bbamcr.2009.07.002 |
0.357 |
|
2009 |
Kassiri Z, Defamie V, Hariri M, Oudit GY, Anthwal S, Dawood F, Liu P, Khokha R. Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart. The Journal of Biological Chemistry. 284: 29893-904. PMID 19625257 DOI: 10.1074/Jbc.M109.028449 |
0.394 |
|
2009 |
Menghini R, Menini S, Amoruso R, Fiorentino L, Casagrande V, Marzano V, Tornei F, Bertucci P, Iacobini C, Serino M, Porzio O, Hribal ML, Folli F, Khokha R, Urbani A, et al. Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology. 136: 663-72.e4. PMID 19027012 DOI: 10.1053/J.Gastro.2008.10.079 |
0.31 |
|
2008 |
Troeberg L, Fushimi K, Khokha R, Emonard H, Ghosh P, Nagase H. Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3515-24. PMID 18632849 DOI: 10.1096/Fj.08-112680 |
0.309 |
|
2008 |
Cruz-Munoz W, Khokha R. The role of tissue inhibitors of metalloproteinases in tumorigenesis and metastasis. Critical Reviews in Clinical Laboratory Sciences. 45: 291-338. PMID 18568853 DOI: 10.1080/10408360801973244 |
0.418 |
|
2008 |
Hojilla CV, Wood GA, Khokha R. Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer. Breast Cancer Research : Bcr. 10: 205. PMID 18394187 DOI: 10.1186/Bcr1980 |
0.435 |
|
2008 |
Murphy G, Murthy A, Khokha R. Clipping, shedding and RIPping keep immunity on cue. Trends in Immunology. 29: 75-82. PMID 18182322 DOI: 10.1016/J.It.2007.10.009 |
0.335 |
|
2008 |
Wetzel M, Li L, Harms KM, Roitbak T, Ventura PB, Rosenberg GA, Khokha R, Cunningham LA. Tissue inhibitor of metalloproteinases-3 facilitates Fas-mediated neuronal cell death following mild ischemia. Cell Death and Differentiation. 15: 143-51. PMID 17962815 DOI: 10.1038/Sj.Cdd.4402246 |
0.332 |
|
2007 |
Wood GA, Fata JE, Watson KLM, Khokha R. Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterus Reproduction. 133: 1035-1044. PMID 17616732 DOI: 10.1530/Rep-06-0302 |
0.358 |
|
2007 |
Sahebjam S, Khokha R, Mort JS. Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice. Arthritis and Rheumatism. 56: 905-9. PMID 17328064 DOI: 10.1002/Art.22427 |
0.333 |
|
2007 |
Hojilla CV, Kim I, Kassiri Z, Fata JE, Fang H, Khokha R. Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3. Journal of Cell Science. 120: 1050-60. PMID 17327279 DOI: 10.1242/Jcs.003335 |
0.36 |
|
2007 |
Jones RA, Campbell CI, Gunther EJ, Chodosh LA, Petrik JJ, Khokha R, Moorehead RA. Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation. Oncogene. 26: 1636-44. PMID 16953219 DOI: 10.1038/Sj.Onc.1209955 |
0.381 |
|
2007 |
Nakajima H, Ito M, Smookler D, Shibata F, Fukuchi Y, Goto-Koshino Y, Arai F, Suda T, Khokha R, Kitamura T. TIMP-3 Inhibition of Angiopoietin-1 Signaling Recruits Hematopoietic Stem Cells from the Bone Marrow Niche. Blood. 110: 1255-1255. DOI: 10.1182/Blood.V110.11.1255.1255 |
0.457 |
|
2006 |
Cruz-Munoz W, Sanchez OH, Di Grappa M, English JL, Hill RP, Khokha R. Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3-/- mice. Oncogene. 25: 6489-96. PMID 16702949 DOI: 10.1038/Sj.Onc.1209663 |
0.404 |
|
2006 |
Jones DH, Nakashima T, Sanchez OH, Kozieradzki I, Komarova SV, Sarosi I, Morony S, Rubin E, Sarao R, Hojilla CV, Komnenovic V, Kong YY, Schreiber M, Dixon SJ, Sims SM, ... Khokha R, et al. Regulation of cancer cell migration and bone metastasis by RANKL. Nature. 440: 692-6. PMID 16572175 DOI: 10.1038/Nature04524 |
0.435 |
|
2006 |
English JL, Kassiri Z, Koskivirta I, Atkinson SJ, Di Grappa M, Soloway PD, Nagase H, Vuorio E, Murphy G, Khokha R. Individual Timp deficiencies differentially impact pro-MMP-2 activation. The Journal of Biological Chemistry. 281: 10337-46. PMID 16469749 DOI: 10.1074/Jbc.M512009200 |
0.35 |
|
2006 |
Smookler DS, Mohammed FF, Kassiri Z, Duncan GS, Mak TW, Khokha R. Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. Journal of Immunology (Baltimore, Md. : 1950). 176: 721-5. PMID 16393953 DOI: 10.4049/Jimmunol.176.2.721 |
0.772 |
|
2006 |
Cruz-Muñoz W, Kim I, Khokha R. TIMP-3 deficiency in the host, but not in the tumor, enhances tumor growth and angiogenesis. Oncogene. 25: 650-5. PMID 16186800 DOI: 10.1038/Sj.Onc.1209104 |
0.376 |
|
2005 |
Mohammed FF, Khokha R. Thinking outside the cell: proteases regulate hepatocyte division. Trends in Cell Biology. 15: 555-63. PMID 16150595 DOI: 10.1016/J.Tcb.2005.08.009 |
0.772 |
|
2005 |
Hakem A, Sanchez-Sweatman O, You-Ten A, Duncan G, Wakeham A, Khokha R, Mak TW. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes & Development. 19: 1974-9. PMID 16107613 DOI: 10.1101/Gad.1310805 |
0.388 |
|
2005 |
Kassiri Z, Oudit GY, Sanchez O, Dawood F, Mohammed FF, Nuttall RK, Edwards DR, Liu PP, Backx PH, Khokha R. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circulation Research. 97: 380-90. PMID 16037568 DOI: 10.1161/01.Res.0000178789.16929.Cf |
0.774 |
|
2005 |
Singh RJ, Mason JC, Lidington EA, Edwards DR, Nuttall RK, Khokha R, Knauper V, Murphy G, Gavrilovic J. Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovascular Research. 67: 39-49. PMID 15949468 DOI: 10.1016/J.Cardiores.2005.02.020 |
0.398 |
|
2005 |
Mahmoodi M, Sahebjam S, Smookler D, Khokha R, Mort JS. Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis. The American Journal of Pathology. 166: 1733-40. PMID 15920158 DOI: 10.1016/S0002-9440(10)62483-2 |
0.324 |
|
2005 |
Li T, Sun L, Miller N, Nicklee T, Woo J, Hulse-Smith L, Tsao MS, Khokha R, Martin L, Boyd N. The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 343-9. PMID 15734956 DOI: 10.1158/1055-9965.Epi-04-0490 |
0.34 |
|
2005 |
Mohammed FF, Pennington CJ, Kassiri Z, Rubin JS, Soloway PD, Ruther U, Edwards DR, Khokha R. Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology (Baltimore, Md.). 41: 857-67. PMID 15726641 DOI: 10.1002/Hep.20618 |
0.791 |
|
2005 |
Kassiri Z, Khokha R. Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors. Thrombosis and Haemostasis. 93: 212-9. PMID 15711735 DOI: 10.1160/Th04-08-0522 |
0.328 |
|
2004 |
Elezkurtaj S, Kopitz C, Baker AH, Perez-Cantó A, Arlt MJ, Khokha R, Gansbacher B, Anton M, Brand K, Krüger A. Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis. The Journal of Gene Medicine. 6: 1228-37. PMID 15390257 DOI: 10.1002/Jgm.637 |
0.395 |
|
2004 |
Mohammed FF, Smookler DS, Taylor SE, Fingleton B, Kassiri Z, Sanchez OH, English JL, Matrisian LM, Au B, Yeh WC, Khokha R. Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nature Genetics. 36: 969-77. PMID 15322543 DOI: 10.1038/Ng1413 |
0.779 |
|
2004 |
Hariri M, Wood GA, DiGrappa MA, MacPherson M, Backman SA, Yaffe MJ, Mak TW, Boyd NF, Khokha R. Experimental manipulation of radiographic density in mouse mammary gland. Breast Cancer Research : Bcr. 6: R540-5. PMID 15318935 DOI: 10.1186/Bcr901 |
0.342 |
|
2004 |
Kong Y, Poon R, Nadesan P, Di Muccio T, Fodde R, Khokha R, Alman BA. Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis. Cancer Research. 64: 5795-803. PMID 15313922 DOI: 10.1158/0008-5472.Can-03-3112 |
0.414 |
|
2004 |
Fedak PW, Smookler DS, Kassiri Z, Ohno N, Leco KJ, Verma S, Mickle DA, Watson KL, Hojilla CV, Cruz W, Weisel RD, Li RK, Khokha R. TIMP-3 deficiency leads to dilated cardiomyopathy. Circulation. 110: 2401-9. PMID 15262835 DOI: 10.1161/01.Cir.0000134959.83967.2D |
0.317 |
|
2004 |
McPherson JP, Lemmers B, Chahwan R, Pamidi A, Migon E, Matysiak-Zablocki E, Moynahan ME, Essers J, Hanada K, Poonepalli A, Sanchez-Sweatman O, Khokha R, Kanaar R, Jasin M, Hande MP, et al. Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science (New York, N.Y.). 304: 1822-6. PMID 15205536 DOI: 10.1126/Science.1094557 |
0.327 |
|
2004 |
McPherson JP, Lemmers B, Hirao A, Hakem A, Abraham J, Migon E, Matysiak-Zablocki E, Tamblyn L, Sanchez-Sweatman O, Khokha R, Squire J, Hande MP, Mak TW, Hakem R. Collaboration of Brca1 and Chk2 in tumorigenesis. Genes & Development. 18: 1144-53. PMID 15131084 DOI: 10.1101/Gad.1192704 |
0.374 |
|
2003 |
Hojilla CV, Mohammed FF, Khokha R. Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development. British Journal of Cancer. 89: 1817-21. PMID 14612884 DOI: 10.1038/Sj.Bjc.6601327 |
0.792 |
|
2003 |
Cairns RA, Khokha R, Hill RP. Molecular mechanisms of tumor invasion and metastasis: an integrated view. Current Molecular Medicine. 3: 659-71. PMID 14601640 DOI: 10.2174/1566524033479447 |
0.431 |
|
2003 |
Griffiths EK, Sanchez O, Mill P, Krawczyk C, Hojilla CV, Rubin E, Nau MM, Khokha R, Lipkowitz S, Hui CC, Penninger JM. Cbl-3-deficient mice exhibit normal epithelial development. Molecular and Cellular Biology. 23: 7708-18. PMID 14560016 DOI: 10.1128/Mcb.23.21.7708-7718.2003 |
0.362 |
|
2003 |
Mohammed FF, Smookler DS, Khokha R. Metalloproteinases, inflammation, and rheumatoid arthritis. Annals of the Rheumatic Diseases. 62: ii43-7. PMID 14532148 DOI: 10.1136/ard.62.suppl_2.ii43 |
0.775 |
|
2003 |
Moorehead RA, Hojilla CV, De Belle I, Wood GA, Fata JE, Adamson ED, Watson KLM, Edwards DR, Khokha R. Insulin-like Growth Factor-II Regulates PTEN Expression in the Mammary Gland Journal of Biological Chemistry. 278: 50422-50427. PMID 14517213 DOI: 10.1074/Jbc.M306894200 |
0.35 |
|
2003 |
Gill SE, Pape MC, Khokha R, Watson AJ, Leco KJ. A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis. Developmental Biology. 261: 313-23. PMID 14499643 DOI: 10.1016/S0012-1606(03)00318-X |
0.324 |
|
2003 |
Schenk S, Hintermann E, Bilban M, Koshikawa N, Hojilla C, Khokha R, Quaranta V. Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution. The Journal of Cell Biology. 161: 197-209. PMID 12695504 DOI: 10.1083/Jcb.200208145 |
0.423 |
|
2003 |
Sasaki T, Irie-Sasaki J, Horie Y, Bachmaier K, Fata JE, Li M, Suzuki A, Bouchard D, Ho A, Redston M, Gallinger S, Khokha R, Mak TW, Hawkins PT, Stephens L, et al. Erratum: Corrigendum: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ Nature. 426: 584-584. DOI: 10.1038/Nature02203 |
0.345 |
|
2001 |
Fata JE, Leco KJ, Voura EB, Yu HYE, Waterhouse P, Murphy G, Moorehead RA, Khokha R. Accelerated apoptosis in the Timp-3-deficient mammary gland Journal of Clinical Investigation. 108: 831-841. PMID 11560952 DOI: 10.1172/Jci13171 |
0.403 |
|
2001 |
Leco KJ, Waterhouse P, Sanchez OH, Gowing KL, Poole AR, Wakeham A, Mak TW, Khokha R. Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3). The Journal of Clinical Investigation. 108: 817-29. PMID 11560951 DOI: 10.1172/Jci12067 |
0.331 |
|
2001 |
Fata JE, Chaudhary V, Khokha R. Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17β-estradiol during the estrous cycle Biology of Reproduction. 65: 680-688. PMID 11514328 DOI: 10.1095/Biolreprod65.3.680 |
0.403 |
|
2001 |
Ho AT, Voura EB, Soloway PD, Watson KLM, Khokha R. MMP Inhibitors Augment Fibroblast Adhesion through Stabilization of Focal Adhesion Contacts and Up-regulation of Cadherin Function Journal of Biological Chemistry. 276: 40215-40224. PMID 11500488 DOI: 10.1074/JBC.M101647200 |
0.329 |
|
2001 |
Ibrahim T, Leong I, Sanchez-Sweatman O, Khokha R, Sodek J, Tenenbaum HC, Ganss B, Cheifetz S. Expression of bone sialoprotein and osteopontin in breast cancer bone metastases. Clinical & Experimental Metastasis. 18: 253-60. PMID 11315099 DOI: 10.1023/A:1006754605901 |
0.31 |
|
2001 |
Moorehead RA, Fata JE, Johnson MB, Khokha R. Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice. Cell Death and Differentiation. 8: 16-29. PMID 11313699 DOI: 10.1038/Sj.Cdd.4400762 |
0.315 |
|
2000 |
Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 103: 41-50. PMID 11051546 DOI: 10.1016/S0092-8674(00)00103-3 |
0.404 |
|
2000 |
Sasaki T, Irie-Sasaki J, Horie Y, Bachmaler K, Fata JE, Li M, Suzuki A, Bouchard D, Ho A, Redston M, Gallinger S, Khokha R, Mak TW, Hawkins PT, Stephens L, et al. Colorectal carcinomas in mice lacking the catalytic submit of PI(3)kγ Nature. 406: 897-902. PMID 10972292 DOI: 10.1038/35022585 |
0.387 |
|
2000 |
Fata JE, Ho AT, Leco KJ, Moorehead RA, Khokha R. Cellular turnover and extracellular matrix remodeling in female reproductive tissues: functions of metalloproteinases and their inhibitors. Cellular and Molecular Life Sciences : Cmls. 57: 77-95. PMID 10949582 DOI: 10.1007/S000180050500 |
0.406 |
|
2000 |
Granovsky M, Fata J, Pawling J, Muller WJ, Khokha R, Dennis JW. Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nature Medicine. 6: 306-12. PMID 10700233 DOI: 10.1038/73163 |
0.351 |
|
2000 |
Thomas P, Khokha R, Shepherd FA, Feld R, Tsao MS. Differential expression of matrix metalloproteinases and their inhibitors in non-small cell lung cancer. The Journal of Pathology. 190: 150-6. PMID 10657012 DOI: 10.1002/(Sici)1096-9896(200002)190:2<150::Aid-Path510>3.3.Co;2-N |
0.361 |
|
2000 |
Michael M, Babic B, Khokha R, Tsao M, Ho J, Pintilie M, Leco K, Chamberlain D, Shepherd FA. Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 17: 1802-8. PMID 10561218 DOI: 10.1200/Jco.1999.17.6.1802 |
0.384 |
|
1999 |
Martin DC, Fowlkes JL, Babic B, Khokha R. Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1. The Journal of Cell Biology. 146: 881-92. PMID 10459021 DOI: 10.1083/Jcb.146.4.881 |
0.362 |
|
1999 |
Fata JE, Leco KJ, Moorehead RA, Martin DC, Khokha R. Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development. Developmental Biology. 211: 238-54. PMID 10395785 DOI: 10.1006/Dbio.1999.9313 |
0.448 |
|
1999 |
Krüger A, Schirrmacher V, Khokha R. The bacterial lacZ gene: an important tool for metastasis research and evaluation of new cancer therapies. Cancer Metastasis Reviews. 17: 285-94. PMID 10352882 DOI: 10.1023/A:1006066706040 |
0.339 |
|
1998 |
Xu F, Carlos T, Li M, Sanchez-Sweatman O, Khokha R, Gorelik E. Inhibition of VLA-4 and up-regulation of TIMP-1 expression in B16BL6 melanoma cells transfected with MHC class I genes. Clinical & Experimental Metastasis. 16: 358-70. PMID 9626815 DOI: 10.1023/A:1006569631330 |
0.34 |
|
1997 |
Krüger A, Fata JE, Khokha R. Altered tumor growth and metastasis of a T-cell lymphoma in Timp-1 transgenic mice Blood. 90: 1993-2000. PMID 9292534 DOI: 10.1182/Blood.V90.5.1993 |
0.381 |
|
1997 |
Leco KJ, Apte SS, Taniguchi GT, Hawkes SP, Khokha R, Schultz GA, Edwards DR. Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues. Febs Letters. 401: 213-7. PMID 9013889 DOI: 10.1016/S0014-5793(96)01474-3 |
0.324 |
|
1996 |
Sharmela Inderdeo D, Edwards DR, Han VKM, Khokha R. Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse Biology of Reproduction. 55: 498-508. PMID 8862765 DOI: 10.1095/Biolreprod55.3.498 |
0.341 |
|
1996 |
Koop S, Schmidt EE, MacDonald IC, Morris VL, Khokha R, Grattan M, Leone J, Chambers AF, Groom AC. Independence of metastatic ability and extravasation: metastatic ras-transformed and control fibroblasts extravasate equally well. Proceedings of the National Academy of Sciences of the United States of America. 93: 11080-4. PMID 8855312 DOI: 10.1073/Pnas.93.20.11080 |
0.384 |
|
1996 |
Chambers AF, MacDonald IC, Schmidt EE, Koop S, Morris VL, Khokha R, Groom AC. Steps in tumor metastasis: new concepts from intravital videomicroscopy. Cancer Metastasis Reviews. 14: 279-301. PMID 8821091 DOI: 10.1007/Bf00690599 |
0.339 |
|
1995 |
Morris VL, Schmidt EE, Koop S, MacDonald IC, Grattan M, Khokha R, McLane MA, Niewiarowski S, Chambers AF, Groom AC. Effects of the disintegrin eristostatin on individual steps of hematogenous metastasis. Experimental Cell Research. 219: 571-8. PMID 7641809 DOI: 10.1006/Excr.1995.1266 |
0.414 |
|
1995 |
Khokha R, Martin DC, Fata JE. Utilization of transgenic mice in the study of matrix degrading proteinases and their inhibitors. Cancer Metastasis Reviews. 14: 97-111. PMID 7554034 DOI: 10.1007/Bf00665794 |
0.389 |
|
1994 |
Khokha R. Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1. Journal of the National Cancer Institute. 86: 299-304. PMID 8158685 DOI: 10.1093/Jnci/86.4.299 |
0.372 |
|
1992 |
Khokha R, Zimmer MJ, Wilson SM, Chambers AF. Up-regulation of TIMP-1 expression in B16-F10 melanoma cells suppresses their metastatic ability in chick embryo. Clinical & Experimental Metastasis. 10: 365-70. PMID 1451346 DOI: 10.1007/Bf00133464 |
0.369 |
|
1992 |
Khokha R, Zimmer MJ, Graham CH, Lala PK, Waterhouse P. Suppression of invasion by inducible expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in B16-F10 melanoma cells. Journal of the National Cancer Institute. 84: 1017-22. PMID 1318976 DOI: 10.1093/Jnci/84.13.1017 |
0.39 |
|
1991 |
Khokha R, Waterhouse P, Lala P, Zimmer M, Denhardt DT. Increased proteinase expression during tumor progression of cell lines down-modulated for TIMP levels: a new transformation paradigm? Journal of Cancer Research and Clinical Oncology. 117: 620. DOI: 10.1007/Bf01613299 |
0.37 |
|
1989 |
Yagel S, Khokha R, Denhardt DT, Kerbel RS, Parhar RS, Lala PK. Mechanisms of cellular invasiveness: A comparison of amnion invasion in vitro and metastatic behavior in vivo Journal of the National Cancer Institute. 81: 768-775. PMID 2541259 DOI: 10.1093/Jnci/81.10.768 |
0.384 |
|
1989 |
Khokha R, Waterhouse P, Yagel S, Lala PK, Overall CM, Norton G, Denhardt DT. Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells Science. 243: 947-950. PMID 2465572 DOI: 10.1126/Science.2465572 |
0.325 |
|
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