Rama Khokha - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Molecular Biology, Medical Biophysics

133 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 O'Kane GM, Grünwald BT, Jang GH, Masoomian M, Picardo S, Grant RC, Denroche RE, Zhang A, Wang Y, Lam B, Krzyzanowski PM, Lungu IM, Bartlett JMS, Peralta M, Vyas F, ... Khokha R, et al. GATA6 expression distinguishes classical and basal-like subtypes in advanced pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32156747 DOI: 10.1158/1078-0432.Ccr-19-3724  0.304
2020 Romero JM, Grünwald BT, Jang GH, Bavi PP, Jhaveri A, Masoomian M, Fischer SE, Zhang A, Denroche RE, Lungu IM, De Luca A, Bartlett JMS, Xu J, Li N, Dhaliwal S, ... ... Khokha R, et al. A four-chemokine signature is associated with a T cell-inflamed phenotype in primary and metastatic pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31964786 DOI: 10.1158/1078-0432.Ccr-19-2803  0.323
2020 Jawhar W, Waterhouse P, Khokha R, Ishii T, Turcotte R, Jabado N, Garzia L. Abstract A64: Functional genomics of metastatic Ewing sarcoma Cancer Research. 80. DOI: 10.1158/1538-7445.Pedca19-A64  0.374
2019 Shehata M, Kim H, Vellanki R, Waterhouse PD, Mahendralingam M, Casey AE, Koritzinsky M, Khokha R. Identifying the murine mammary cell target of metformin exposure. Communications Biology. 2: 192. PMID 31925073 DOI: 10.1038/s42003-019-0439-x  0.321
2019 Saw S, Weiss A, Khokha R, Waterhouse PD. Metalloproteases: On the Watch in the Hematopoietic Niche. Trends in Immunology. PMID 31645297 DOI: 10.1016/J.It.2019.09.006  0.403
2019 Saw S, Aiken A, Fang H, McKee TD, Bregant S, Sanchez O, Chen Y, Weiss A, Dickson BC, Czarny B, Sinha A, Fosang A, Dive V, Waterhouse PD, Kislinger T, ... Khokha R, et al. Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth. The Journal of Cell Biology. PMID 31371388 DOI: 10.1083/Jcb.201906059  0.329
2019 Tharmapalan P, Mahendralingam M, Berman HK, Khokha R. Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention. The Embo Journal. 38: e100852. PMID 31267556 DOI: 10.15252/Embj.2018100852  0.439
2019 Shehata M, Kim H, Vellanki R, Waterhouse PD, Mahendralingam M, Casey AE, Koritzinsky M, Khokha R. Identifying the murine mammary cell target of metformin exposure. Communications Biology. 2: 192. PMID 31123716 DOI: 10.1038/s42003-019-0439-x  0.321
2019 Joshi PA, Waterhouse PD, Kasaian K, Fang H, Gulyaeva O, Sul HS, Boutros PC, Khokha R. PDGFRα stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland. Nature Communications. 10: 1760. PMID 30988300 DOI: 10.1038/S41467-019-09748-Z  0.792
2018 Shehata M, Waterhouse PD, Casey AE, Fang H, Hazelwood L, Khokha R. Proliferative heterogeneity of murine epithelial cells in the adult mammary gland. Communications Biology. 1: 111. PMID 30271991 DOI: 10.1038/s42003-018-0114-7  0.341
2018 Li L, Guturi KKN, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, et al. Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. The Journal of Clinical Investigation. PMID 30222135 DOI: 10.1172/Jci120401  0.428
2018 Chen Y, Aiken A, Saw S, Weiss A, Fang H, Khokha R. TIMP loss activates metalloproteinase-TNFα-DKK1 axis to compromise Wnt signaling and bone mass. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. PMID 30216540 DOI: 10.1002/Jbmr.3585  0.33
2018 Shao YW, Wood GA, Lu J, Tang QL, Liu J, Molyneux S, Chen Y, Fang H, Adissu H, McKee T, Waterhouse P, Khokha R. Cross-species genomics identifies DLG2 as a tumor suppressor in osteosarcoma. Oncogene. PMID 30093633 DOI: 10.1038/S41388-018-0444-4  0.332
2018 Casey AE, Sinha A, Singhania R, Livingstone J, Waterhouse P, Tharmapalan P, Cruickshank J, Shehata M, Drysdale E, Fang H, Kim H, Isserlin R, Bailey S, Medina T, Deblois G, ... ... Khokha R, et al. Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities. The Journal of Cell Biology. PMID 29921600 DOI: 10.1083/Jcb.201804042  0.442
2018 Tang Q, Lu J, Zou C, Shao Y, Chen Y, Narala S, Fang H, Xu H, Wang J, Shen J, Khokha R. CDH4 is a novel determinant of osteosarcoma tumorigenesis and metastasis. Oncogene. PMID 29610525 DOI: 10.1038/S41388-018-0231-2  0.363
2017 Shimoda M, Khokha R. Metalloproteinases in extracellular vesicles. Biochimica Et Biophysica Acta. PMID 28578911 DOI: 10.1016/J.Bbamcr.2017.05.027  0.41
2017 Voura EB, Montalvo MJ, Dela Roca KT, Fisher JM, Defamie V, Narala SR, Khokha R, Mulligan ME, Evans CA. Planarians as models of cadmium-induced neoplasia provide measurable benchmarks for mechanistic studies. Ecotoxicology and Environmental Safety. 142: 544-554. PMID 28482323 DOI: 10.1016/J.Ecoenv.2017.04.044  0.401
2016 Jackson HW, Defamie V, Waterhouse P, Khokha R. TIMPs: versatile extracellular regulators in cancer. Nature Reviews. Cancer. PMID 27932800 DOI: 10.1038/Nrc.2016.115  0.408
2016 Shimoda M, Jackson HW, Khokha R. Tumor suppression by stromal TIMPs. Molecular & Cellular Oncology. 3: e975082. PMID 27314104 DOI: 10.4161/23723556.2014.975082  0.36
2016 Sigl V, Owusu-Boaitey K, Joshi PA, Kavirayani A, Wirnsberger G, Novatchkova M, Kozieradzki I, Schramek D, Edokobi N, Hersl J, Sampson A, Odai-Afotey A, Lazaro C, Gonzalez-Suarez E, Pujana MA, ... ... Khokha R, et al. RANKL/RANK control Brca1 mutation-driven mammary tumors. Cell Research. PMID 27241552 DOI: 10.1038/Cr.2016.69  0.773
2015 Shiah YJ, Tharmapalan P, Casey AE, Joshi PA, McKee TD, Jackson HW, Beristain AG, Chan-Seng-Yue MA, Bader GD, Lydon JP, Waterhouse PD, Boutros PC, Khokha R. A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland. Stem Cell Reports. 4: 313-322. PMID 28447939 DOI: 10.1016/J.Stemcr.2015.01.011  0.799
2015 Chen Y, Di Grappa MA, Molyneux SD, McKee TD, Waterhouse P, Penninger JM, Khokha R. RANKL blockade prevents and treats aggressive osteosarcomas. Science Translational Medicine. 7: 317ra197. PMID 26659571 DOI: 10.1126/Scitranslmed.Aad0295  0.325
2015 Joshi PA, Goodwin PJ, Khokha R. Progesterone and Synthetic Progestin Controversies-Reply. Jama Oncology. 1: 987-8. PMID 26448288 DOI: 10.1001/Jamaoncol.2015.2294  0.73
2015 Adissu HA, McKerlie C, Di Grappa M, Waterhouse P, Xu Q, Fang H, Khokha R, Wood GA. Timp3 loss accelerates tumour invasion and increases prostate inflammation in a mouse model of prostate cancer. The Prostate. PMID 26332574 DOI: 10.1002/Pros.23056  0.35
2015 Joshi PA, Goodwin PJ, Khokha R. Progesterone Exposure and Breast Cancer Risk: Understanding the Biological Roots. Jama Oncology. 1: 283-5. PMID 26181171 DOI: 10.1001/Jamaoncol.2015.0512  0.752
2015 Joshi PA, Waterhouse PD, Kannan N, Narala S, Fang H, Di Grappa MA, Jackson HW, Penninger JM, Eaves C, Khokha R. RANK Signaling Amplifies WNT-Responsive Mammary Progenitors through R-SPONDIN1. Stem Cell Reports. 5: 31-44. PMID 26095608 DOI: 10.1016/J.Stemcr.2015.05.012  0.793
2015 Jackson HW, Hojilla CV, Weiss A, Sanchez OH, Wood GA, Khokha R. Timp3 deficient mice show resistance to developing breast cancer. Plos One. 10: e0120107. PMID 25807548 DOI: 10.1371/Journal.Pone.0120107  0.426
2015 Jackson HW, Waterhouse P, Sinha A, Kislinger T, Berman HK, Khokha R. Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 null mice. Nature Cell Biology. 17: 217-27. PMID 25706237 DOI: 10.1038/Ncb3118  0.38
2015 Shiah YJ, Tharmapalan P, Casey AE, Joshi PA, McKee TD, Jackson HW, Beristain AG, Chan-Seng-Yue MA, Bader GD, Lydon JP, Waterhouse PD, Boutros PC, Khokha R. A progesterone-CXCR4 axis controls mammary progenitor cell fate in the adult gland. Stem Cell Reports. 4: 313-22. PMID 25702641 DOI: 10.1016/j.stemcr.2015.01.011  0.794
2015 Harris IS, Treloar AE, Inoue S, Sasaki M, Gorrini C, Lee KC, Yung KY, Brenner D, Knobbe-Thomsen CB, Cox MA, Elia A, Berger T, Cescon DW, Adeoye A, Brüstle A, ... ... Khokha R, et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell. 27: 211-22. PMID 25620030 DOI: 10.1016/J.Ccell.2014.11.019  0.35
2015 Beristain AG, Molyneux SD, Joshi PA, Pomroy NC, Di Grappa MA, Chang MC, Kirschner LS, Privé GG, Pujana MA, Khokha R. PKA signaling drives mammary tumorigenesis through Src. Oncogene. 34: 1160-73. PMID 24662820 DOI: 10.1038/Onc.2014.41  0.789
2014 Defamie V, Sanchez O, Murthy A, Khokha R. TIMP3 controls cell fate to confer hepatocellular carcinoma resistance. Oncogene. PMID 25347747 DOI: 10.1038/Onc.2014.339  0.392
2014 Shimoda M, Principe S, Jackson HW, Luga V, Fang H, Molyneux SD, Shao YW, Aiken A, Waterhouse PD, Karamboulas C, Hess FM, Ohtsuka T, Okada Y, Ailles L, Ludwig A, ... ... Khokha R, et al. Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state. Nature Cell Biology. 16: 889-901. PMID 25150980 DOI: 10.1038/Ncb3021  0.472
2014 Molyneux SD, Waterhouse PD, Shelton D, Shao YW, Watling CM, Tang QL, Harris IS, Dickson BC, Tharmapalan P, Sandve GK, Zhang X, Bailey SD, Berman H, Wunder JS, Izsvák Z, ... ... Khokha R, et al. Human somatic cell mutagenesis creates genetically tractable sarcomas. Nature Genetics. 46: 964-72. PMID 25129143 DOI: 10.1038/Ng.3065  0.343
2014 Penfornis P, Cai DZ, Harris MR, Walker R, Licini D, Fernandes JD, Orr G, Koganti T, Hicks C, Induru S, Meyer MS, Khokha R, Barr J, Pochampally RR. High CD49f expression is associated with osteosarcoma tumor progression: a study using patient-derived primary cell cultures. Cancer Medicine. 3: 796-811. PMID 24802970 DOI: 10.1002/Cam4.249  0.406
2014 Alexander CM, Joshi PA, Khokha R. Fully interlocking: a story of teamwork among breast epithelial cells. Developmental Cell. 28: 114-5. PMID 24480641 DOI: 10.1016/J.Devcel.2014.01.011  0.769
2013 Wei LZ, Xu Y, Nelles EM, Furlonger C, Wang JC, Di Grappa MA, Khokha R, Medin JA, Paige CJ. Localized interleukin-12 delivery for immunotherapy of solid tumours. Journal of Cellular and Molecular Medicine. 17: 1465-74. PMID 24251770 DOI: 10.1111/Jcmm.12121  0.309
2013 Voura EB, English JL, Yu HY, Ho AT, Subarsky P, Hill RP, Hojilla CV, Khokha R. Proteolysis during tumor cell extravasation in vitro: metalloproteinase involvement across tumor cell types. Plos One. 8: e78413. PMID 24194929 DOI: 10.1371/Journal.Pone.0078413  0.401
2013 Khokha R, Murthy A, Weiss A. Metalloproteinases and their natural inhibitors in inflammation and immunity. Nature Reviews. Immunology. 13: 649-65. PMID 23969736 DOI: 10.1038/Nri3499  0.377
2013 Gorrini C, Baniasadi PS, Harris IS, Silvester J, Inoue S, Snow B, Joshi PA, Wakeham A, Molyneux SD, Martin B, Bouwman P, Cescon DW, Elia AJ, Winterton-Perks Z, Cruickshank J, ... ... Khokha R, et al. BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival. The Journal of Experimental Medicine. 210: 1529-44. PMID 23857982 DOI: 10.1084/Jem.20121337  0.77
2013 Shimoda M, Khokha R. Proteolytic factors in exosomes. Proteomics. 13: 1624-36. PMID 23526769 DOI: 10.1002/Pmic.201200458  0.395
2013 Lee HJ, Gallego-Ortega D, Ledger A, Schramek D, Joshi P, Szwarc MM, Cho C, Lydon JP, Khokha R, Penninger JM, Ormandy CJ. Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells. Development (Cambridge, England). 140: 1397-401. PMID 23462470 DOI: 10.1242/Dev.088948  0.792
2013 Hewing NJ, Weskamp G, Vermaat J, Farage E, Glomski K, Swendeman S, Chan RV, Chiang MF, Khokha R, Anand-Apte B, Blobel CP. Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice. Investigative Ophthalmology & Visual Science. 54: 864-70. PMID 23299479 DOI: 10.1167/Iovs.12-10954  0.33
2013 Shiah Y, Joshi PA, Beristain AG, Chan-Seng-Yue M, Boutros PC, Khokha R. Abstract B023: Identifying molecular programs of progesterone-driven mammary stem cell expansion Molecular Cancer Research. 11. DOI: 10.1158/1557-3125.Advbc-B023  0.804
2012 Joshi PA, Di Grappa MA, Khokha R. Active allies: hormones, stem cells and the niche in adult mammopoiesis. Trends in Endocrinology and Metabolism: Tem. 23: 299-309. PMID 22613704 DOI: 10.1016/J.Tem.2012.04.002  0.784
2012 Joshi PA, Khokha R. The mammary stem cell conundrum: is it unipotent or multipotent? Breast Cancer Research : Bcr. 14: 305. PMID 22424095 DOI: 10.1186/Bcr3123  0.784
2012 Beristain AG, Narala SR, Di Grappa MA, Khokha R. Homotypic RANK signaling differentially regulates proliferation, motility and cell survival in osteosarcoma and mammary epithelial cells. Journal of Cell Science. 125: 943-55. PMID 22421365 DOI: 10.1242/Jcs.094029  0.458
2012 Murthy A, Shao YW, Defamie V, Wedeles C, Smookler D, Khokha R. Stromal TIMP3 regulates liver lymphocyte populations and provides protection against Th1 T cell-driven autoimmune hepatitis. Journal of Immunology (Baltimore, Md. : 1950). 188: 2876-83. PMID 22323541 DOI: 10.4049/Jimmunol.1102199  0.392
2012 Murthy A, Shao YW, Narala SR, Molyneux SD, Zúñiga-Pflücker JC, Khokha R. Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis. Immunity. 36: 105-19. PMID 22284418 DOI: 10.1016/J.Immuni.2012.01.005  0.351
2012 McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, Lang KS, Häussinger D, Wakeham A, Itie-Youten A, Khokha R, et al. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science (New York, N.Y.). 335: 229-32. PMID 22246778 DOI: 10.1126/Science.1214448  0.326
2012 Sanchezsweatman O, Soares F, Whaley M, Khokha R, Orr F, Singh G. Differential regulation of matrix metalloproteinases in human cancer cells by exogenous factors. International Journal of Oncology. 11: 1321-6. PMID 21528341 DOI: 10.3892/Ijo.11.6.1321  0.433
2011 Hojilla CV, Jackson HW, Khokha R. TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence. Plos One. 6: e26718. PMID 22053204 DOI: 10.1371/Journal.Pone.0026718  0.433
2011 Ebrahem Q, Qi JH, Sugimoto M, Ali M, Sears JE, Cutler A, Khokha R, Vasanji A, Anand-Apte B. Increased neovascularization in mice lacking tissue inhibitor of metalloproteinases-3. Investigative Ophthalmology & Visual Science. 52: 6117-23. PMID 21282576 DOI: 10.1167/Iovs.10-5899  0.373
2011 Khokha R, Werb Z. Mammary gland reprogramming: metalloproteinases couple form with function. Cold Spring Harbor Perspectives in Biology. 3. PMID 21106646 DOI: 10.1101/Cshperspect.A004333  0.352
2010 Le Gall SM, Maretzky T, Issuree PD, Niu XD, Reiss K, Saftig P, Khokha R, Lundell D, Blobel CP. ADAM17 is regulated by a rapid and reversible mechanism that controls access to its catalytic site. Journal of Cell Science. 123: 3913-22. PMID 20980382 DOI: 10.1242/Jcs.069997  0.35
2010 Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, et al. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 468: 98-102. PMID 20881962 DOI: 10.1038/Nature09387  0.789
2010 Nakajima H, Ito M, Smookler DS, Shibata F, Fukuchi Y, Morikawa Y, Ikeda Y, Arai F, Suda T, Khokha R, Kitamura T. TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool. Blood. 116: 4474-82. PMID 20798233 DOI: 10.1182/Blood-2010-01-266528  0.461
2010 Molyneux SD, Di Grappa MA, Beristain AG, McKee TD, Wai DH, Paderova J, Kashyap M, Hu P, Maiuri T, Narala SR, Stambolic V, Squire J, Penninger J, Sanchez O, Triche TJ, ... ... Khokha R, et al. Prkar1a is an osteosarcoma tumor suppressor that defines a molecular subclass in mice. The Journal of Clinical Investigation. 120: 3310-25. PMID 20697156 DOI: 10.1172/Jci42391  0.346
2010 Murthy A, Defamie V, Smookler DS, Di Grappa MA, Horiuchi K, Federici M, Sibilia M, Blobel CP, Khokha R. Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice. The Journal of Clinical Investigation. 120: 2731-44. PMID 20628198 DOI: 10.1172/Jci42686  0.383
2010 Koskivirta I, Kassiri Z, Rahkonen O, Kiviranta R, Oudit GY, McKee TD, Kytö V, Saraste A, Jokinen E, Liu PP, Vuorio E, Khokha R. Mice with tissue inhibitor of metalloproteinases 4 (Timp4) deletion succumb to induced myocardial infarction but not to cardiac pressure overload. The Journal of Biological Chemistry. 285: 24487-93. PMID 20516072 DOI: 10.1074/Jbc.M110.136820  0.342
2010 Joshi PA, Jackson HW, Beristain AG, Di Grappa MA, Mote PA, Clarke CL, Stingl J, Waterhouse PD, Khokha R. Progesterone induces adult mammary stem cell expansion. Nature. 465: 803-7. PMID 20445538 DOI: 10.1038/Nature09091  0.807
2010 Gill SE, Huizar I, Bench EM, Sussman SW, Wang Y, Khokha R, Parks WC. Tissue inhibitor of metalloproteinases 3 regulates resolution of inflammation following acute lung injury American Journal of Pathology. 176: 64-73. PMID 20008147 DOI: 10.2353/Ajpath.2010.090158  0.323
2010 Fiorentino L, Vivanti A, Cavalera M, Marzano V, Ronci M, Fabrizi M, Menini S, Pugliese G, Menghini R, Khokha R, Lauro R, Urbani A, Federici M. Increased tumor necrosis factor alpha-converting enzyme activity induces insulin resistance and hepatosteatosis in mice. Hepatology (Baltimore, Md.). 51: 103-10. PMID 19877183 DOI: 10.1002/Hep.23250  0.32
2010 Aiken A, Khokha R. Unraveling metalloproteinase function in skeletal biology and disease using genetically altered mice. Biochimica Et Biophysica Acta. 1803: 121-32. PMID 19616584 DOI: 10.1016/J.Bbamcr.2009.07.002  0.357
2009 Kassiri Z, Defamie V, Hariri M, Oudit GY, Anthwal S, Dawood F, Liu P, Khokha R. Simultaneous transforming growth factor beta-tumor necrosis factor activation and cross-talk cause aberrant remodeling response and myocardial fibrosis in Timp3-deficient heart. The Journal of Biological Chemistry. 284: 29893-904. PMID 19625257 DOI: 10.1074/Jbc.M109.028449  0.394
2009 Menghini R, Menini S, Amoruso R, Fiorentino L, Casagrande V, Marzano V, Tornei F, Bertucci P, Iacobini C, Serino M, Porzio O, Hribal ML, Folli F, Khokha R, Urbani A, et al. Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology. 136: 663-72.e4. PMID 19027012 DOI: 10.1053/J.Gastro.2008.10.079  0.31
2008 Troeberg L, Fushimi K, Khokha R, Emonard H, Ghosh P, Nagase H. Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3515-24. PMID 18632849 DOI: 10.1096/Fj.08-112680  0.309
2008 Cruz-Munoz W, Khokha R. The role of tissue inhibitors of metalloproteinases in tumorigenesis and metastasis. Critical Reviews in Clinical Laboratory Sciences. 45: 291-338. PMID 18568853 DOI: 10.1080/10408360801973244  0.418
2008 Hojilla CV, Wood GA, Khokha R. Inflammation and breast cancer: metalloproteinases as common effectors of inflammation and extracellular matrix breakdown in breast cancer. Breast Cancer Research : Bcr. 10: 205. PMID 18394187 DOI: 10.1186/Bcr1980  0.435
2008 Murphy G, Murthy A, Khokha R. Clipping, shedding and RIPping keep immunity on cue. Trends in Immunology. 29: 75-82. PMID 18182322 DOI: 10.1016/J.It.2007.10.009  0.335
2008 Wetzel M, Li L, Harms KM, Roitbak T, Ventura PB, Rosenberg GA, Khokha R, Cunningham LA. Tissue inhibitor of metalloproteinases-3 facilitates Fas-mediated neuronal cell death following mild ischemia. Cell Death and Differentiation. 15: 143-51. PMID 17962815 DOI: 10.1038/Sj.Cdd.4402246  0.332
2007 Wood GA, Fata JE, Watson KLM, Khokha R. Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterus Reproduction. 133: 1035-1044. PMID 17616732 DOI: 10.1530/Rep-06-0302  0.358
2007 Sahebjam S, Khokha R, Mort JS. Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice. Arthritis and Rheumatism. 56: 905-9. PMID 17328064 DOI: 10.1002/Art.22427  0.333
2007 Hojilla CV, Kim I, Kassiri Z, Fata JE, Fang H, Khokha R. Metalloproteinase axes increase beta-catenin signaling in primary mouse mammary epithelial cells lacking TIMP3. Journal of Cell Science. 120: 1050-60. PMID 17327279 DOI: 10.1242/Jcs.003335  0.36
2007 Jones RA, Campbell CI, Gunther EJ, Chodosh LA, Petrik JJ, Khokha R, Moorehead RA. Transgenic overexpression of IGF-IR disrupts mammary ductal morphogenesis and induces tumor formation. Oncogene. 26: 1636-44. PMID 16953219 DOI: 10.1038/Sj.Onc.1209955  0.381
2007 Nakajima H, Ito M, Smookler D, Shibata F, Fukuchi Y, Goto-Koshino Y, Arai F, Suda T, Khokha R, Kitamura T. TIMP-3 Inhibition of Angiopoietin-1 Signaling Recruits Hematopoietic Stem Cells from the Bone Marrow Niche. Blood. 110: 1255-1255. DOI: 10.1182/Blood.V110.11.1255.1255  0.457
2006 Cruz-Munoz W, Sanchez OH, Di Grappa M, English JL, Hill RP, Khokha R. Enhanced metastatic dissemination to multiple organs by melanoma and lymphoma cells in timp-3-/- mice. Oncogene. 25: 6489-96. PMID 16702949 DOI: 10.1038/Sj.Onc.1209663  0.404
2006 Jones DH, Nakashima T, Sanchez OH, Kozieradzki I, Komarova SV, Sarosi I, Morony S, Rubin E, Sarao R, Hojilla CV, Komnenovic V, Kong YY, Schreiber M, Dixon SJ, Sims SM, ... Khokha R, et al. Regulation of cancer cell migration and bone metastasis by RANKL. Nature. 440: 692-6. PMID 16572175 DOI: 10.1038/Nature04524  0.435
2006 English JL, Kassiri Z, Koskivirta I, Atkinson SJ, Di Grappa M, Soloway PD, Nagase H, Vuorio E, Murphy G, Khokha R. Individual Timp deficiencies differentially impact pro-MMP-2 activation. The Journal of Biological Chemistry. 281: 10337-46. PMID 16469749 DOI: 10.1074/Jbc.M512009200  0.35
2006 Smookler DS, Mohammed FF, Kassiri Z, Duncan GS, Mak TW, Khokha R. Tissue inhibitor of metalloproteinase 3 regulates TNF-dependent systemic inflammation. Journal of Immunology (Baltimore, Md. : 1950). 176: 721-5. PMID 16393953 DOI: 10.4049/Jimmunol.176.2.721  0.772
2006 Cruz-Muñoz W, Kim I, Khokha R. TIMP-3 deficiency in the host, but not in the tumor, enhances tumor growth and angiogenesis. Oncogene. 25: 650-5. PMID 16186800 DOI: 10.1038/Sj.Onc.1209104  0.376
2005 Mohammed FF, Khokha R. Thinking outside the cell: proteases regulate hepatocyte division. Trends in Cell Biology. 15: 555-63. PMID 16150595 DOI: 10.1016/J.Tcb.2005.08.009  0.772
2005 Hakem A, Sanchez-Sweatman O, You-Ten A, Duncan G, Wakeham A, Khokha R, Mak TW. RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis. Genes & Development. 19: 1974-9. PMID 16107613 DOI: 10.1101/Gad.1310805  0.388
2005 Kassiri Z, Oudit GY, Sanchez O, Dawood F, Mohammed FF, Nuttall RK, Edwards DR, Liu PP, Backx PH, Khokha R. Combination of tumor necrosis factor-alpha ablation and matrix metalloproteinase inhibition prevents heart failure after pressure overload in tissue inhibitor of metalloproteinase-3 knock-out mice. Circulation Research. 97: 380-90. PMID 16037568 DOI: 10.1161/01.Res.0000178789.16929.Cf  0.774
2005 Singh RJ, Mason JC, Lidington EA, Edwards DR, Nuttall RK, Khokha R, Knauper V, Murphy G, Gavrilovic J. Cytokine stimulated vascular cell adhesion molecule-1 (VCAM-1) ectodomain release is regulated by TIMP-3. Cardiovascular Research. 67: 39-49. PMID 15949468 DOI: 10.1016/J.Cardiores.2005.02.020  0.398
2005 Mahmoodi M, Sahebjam S, Smookler D, Khokha R, Mort JS. Lack of tissue inhibitor of metalloproteinases-3 results in an enhanced inflammatory response in antigen-induced arthritis. The American Journal of Pathology. 166: 1733-40. PMID 15920158 DOI: 10.1016/S0002-9440(10)62483-2  0.324
2005 Li T, Sun L, Miller N, Nicklee T, Woo J, Hulse-Smith L, Tsao MS, Khokha R, Martin L, Boyd N. The association of measured breast tissue characteristics with mammographic density and other risk factors for breast cancer. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 14: 343-9. PMID 15734956 DOI: 10.1158/1055-9965.Epi-04-0490  0.34
2005 Mohammed FF, Pennington CJ, Kassiri Z, Rubin JS, Soloway PD, Ruther U, Edwards DR, Khokha R. Metalloproteinase inhibitor TIMP-1 affects hepatocyte cell cycle via HGF activation in murine liver regeneration. Hepatology (Baltimore, Md.). 41: 857-67. PMID 15726641 DOI: 10.1002/Hep.20618  0.791
2005 Kassiri Z, Khokha R. Myocardial extra-cellular matrix and its regulation by metalloproteinases and their inhibitors. Thrombosis and Haemostasis. 93: 212-9. PMID 15711735 DOI: 10.1160/Th04-08-0522  0.328
2004 Elezkurtaj S, Kopitz C, Baker AH, Perez-Cantó A, Arlt MJ, Khokha R, Gansbacher B, Anton M, Brand K, Krüger A. Adenovirus-mediated overexpression of tissue inhibitor of metalloproteinases-1 in the liver: efficient protection against T-cell lymphoma and colon carcinoma metastasis. The Journal of Gene Medicine. 6: 1228-37. PMID 15390257 DOI: 10.1002/Jgm.637  0.395
2004 Mohammed FF, Smookler DS, Taylor SE, Fingleton B, Kassiri Z, Sanchez OH, English JL, Matrisian LM, Au B, Yeh WC, Khokha R. Abnormal TNF activity in Timp3-/- mice leads to chronic hepatic inflammation and failure of liver regeneration. Nature Genetics. 36: 969-77. PMID 15322543 DOI: 10.1038/Ng1413  0.779
2004 Hariri M, Wood GA, DiGrappa MA, MacPherson M, Backman SA, Yaffe MJ, Mak TW, Boyd NF, Khokha R. Experimental manipulation of radiographic density in mouse mammary gland. Breast Cancer Research : Bcr. 6: R540-5. PMID 15318935 DOI: 10.1186/Bcr901  0.342
2004 Kong Y, Poon R, Nadesan P, Di Muccio T, Fodde R, Khokha R, Alman BA. Matrix metalloproteinase activity modulates tumor size, cell motility, and cell invasiveness in murine aggressive fibromatosis. Cancer Research. 64: 5795-803. PMID 15313922 DOI: 10.1158/0008-5472.Can-03-3112  0.414
2004 Fedak PW, Smookler DS, Kassiri Z, Ohno N, Leco KJ, Verma S, Mickle DA, Watson KL, Hojilla CV, Cruz W, Weisel RD, Li RK, Khokha R. TIMP-3 deficiency leads to dilated cardiomyopathy. Circulation. 110: 2401-9. PMID 15262835 DOI: 10.1161/01.Cir.0000134959.83967.2D  0.317
2004 McPherson JP, Lemmers B, Chahwan R, Pamidi A, Migon E, Matysiak-Zablocki E, Moynahan ME, Essers J, Hanada K, Poonepalli A, Sanchez-Sweatman O, Khokha R, Kanaar R, Jasin M, Hande MP, et al. Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science (New York, N.Y.). 304: 1822-6. PMID 15205536 DOI: 10.1126/Science.1094557  0.327
2004 McPherson JP, Lemmers B, Hirao A, Hakem A, Abraham J, Migon E, Matysiak-Zablocki E, Tamblyn L, Sanchez-Sweatman O, Khokha R, Squire J, Hande MP, Mak TW, Hakem R. Collaboration of Brca1 and Chk2 in tumorigenesis. Genes & Development. 18: 1144-53. PMID 15131084 DOI: 10.1101/Gad.1192704  0.374
2003 Hojilla CV, Mohammed FF, Khokha R. Matrix metalloproteinases and their tissue inhibitors direct cell fate during cancer development. British Journal of Cancer. 89: 1817-21. PMID 14612884 DOI: 10.1038/Sj.Bjc.6601327  0.792
2003 Cairns RA, Khokha R, Hill RP. Molecular mechanisms of tumor invasion and metastasis: an integrated view. Current Molecular Medicine. 3: 659-71. PMID 14601640 DOI: 10.2174/1566524033479447  0.431
2003 Griffiths EK, Sanchez O, Mill P, Krawczyk C, Hojilla CV, Rubin E, Nau MM, Khokha R, Lipkowitz S, Hui CC, Penninger JM. Cbl-3-deficient mice exhibit normal epithelial development. Molecular and Cellular Biology. 23: 7708-18. PMID 14560016 DOI: 10.1128/Mcb.23.21.7708-7718.2003  0.362
2003 Mohammed FF, Smookler DS, Khokha R. Metalloproteinases, inflammation, and rheumatoid arthritis. Annals of the Rheumatic Diseases. 62: ii43-7. PMID 14532148 DOI: 10.1136/ard.62.suppl_2.ii43  0.775
2003 Moorehead RA, Hojilla CV, De Belle I, Wood GA, Fata JE, Adamson ED, Watson KLM, Edwards DR, Khokha R. Insulin-like Growth Factor-II Regulates PTEN Expression in the Mammary Gland Journal of Biological Chemistry. 278: 50422-50427. PMID 14517213 DOI: 10.1074/Jbc.M306894200  0.35
2003 Gill SE, Pape MC, Khokha R, Watson AJ, Leco KJ. A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis. Developmental Biology. 261: 313-23. PMID 14499643 DOI: 10.1016/S0012-1606(03)00318-X  0.324
2003 Schenk S, Hintermann E, Bilban M, Koshikawa N, Hojilla C, Khokha R, Quaranta V. Binding to EGF receptor of a laminin-5 EGF-like fragment liberated during MMP-dependent mammary gland involution. The Journal of Cell Biology. 161: 197-209. PMID 12695504 DOI: 10.1083/Jcb.200208145  0.423
2003 Sasaki T, Irie-Sasaki J, Horie Y, Bachmaier K, Fata JE, Li M, Suzuki A, Bouchard D, Ho A, Redston M, Gallinger S, Khokha R, Mak TW, Hawkins PT, Stephens L, et al. Erratum: Corrigendum: Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ Nature. 426: 584-584. DOI: 10.1038/Nature02203  0.345
2001 Fata JE, Leco KJ, Voura EB, Yu HYE, Waterhouse P, Murphy G, Moorehead RA, Khokha R. Accelerated apoptosis in the Timp-3-deficient mammary gland Journal of Clinical Investigation. 108: 831-841. PMID 11560952 DOI: 10.1172/Jci13171  0.403
2001 Leco KJ, Waterhouse P, Sanchez OH, Gowing KL, Poole AR, Wakeham A, Mak TW, Khokha R. Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3). The Journal of Clinical Investigation. 108: 817-29. PMID 11560951 DOI: 10.1172/Jci12067  0.331
2001 Fata JE, Chaudhary V, Khokha R. Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17β-estradiol during the estrous cycle Biology of Reproduction. 65: 680-688. PMID 11514328 DOI: 10.1095/Biolreprod65.3.680  0.403
2001 Ho AT, Voura EB, Soloway PD, Watson KLM, Khokha R. MMP Inhibitors Augment Fibroblast Adhesion through Stabilization of Focal Adhesion Contacts and Up-regulation of Cadherin Function Journal of Biological Chemistry. 276: 40215-40224. PMID 11500488 DOI: 10.1074/JBC.M101647200  0.329
2001 Ibrahim T, Leong I, Sanchez-Sweatman O, Khokha R, Sodek J, Tenenbaum HC, Ganss B, Cheifetz S. Expression of bone sialoprotein and osteopontin in breast cancer bone metastases. Clinical & Experimental Metastasis. 18: 253-60. PMID 11315099 DOI: 10.1023/A:1006754605901  0.31
2001 Moorehead RA, Fata JE, Johnson MB, Khokha R. Inhibition of mammary epithelial apoptosis and sustained phosphorylation of Akt/PKB in MMTV-IGF-II transgenic mice. Cell Death and Differentiation. 8: 16-29. PMID 11313699 DOI: 10.1038/Sj.Cdd.4400762  0.315
2000 Fata JE, Kong YY, Li J, Sasaki T, Irie-Sasaki J, Moorehead RA, Elliott R, Scully S, Voura EB, Lacey DL, Boyle WJ, Khokha R, Penninger JM. The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development. Cell. 103: 41-50. PMID 11051546 DOI: 10.1016/S0092-8674(00)00103-3  0.404
2000 Sasaki T, Irie-Sasaki J, Horie Y, Bachmaler K, Fata JE, Li M, Suzuki A, Bouchard D, Ho A, Redston M, Gallinger S, Khokha R, Mak TW, Hawkins PT, Stephens L, et al. Colorectal carcinomas in mice lacking the catalytic submit of PI(3)kγ Nature. 406: 897-902. PMID 10972292 DOI: 10.1038/35022585  0.387
2000 Fata JE, Ho AT, Leco KJ, Moorehead RA, Khokha R. Cellular turnover and extracellular matrix remodeling in female reproductive tissues: functions of metalloproteinases and their inhibitors. Cellular and Molecular Life Sciences : Cmls. 57: 77-95. PMID 10949582 DOI: 10.1007/S000180050500  0.406
2000 Granovsky M, Fata J, Pawling J, Muller WJ, Khokha R, Dennis JW. Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nature Medicine. 6: 306-12. PMID 10700233 DOI: 10.1038/73163  0.351
2000 Thomas P, Khokha R, Shepherd FA, Feld R, Tsao MS. Differential expression of matrix metalloproteinases and their inhibitors in non-small cell lung cancer. The Journal of Pathology. 190: 150-6. PMID 10657012 DOI: 10.1002/(Sici)1096-9896(200002)190:2<150::Aid-Path510>3.3.Co;2-N  0.361
2000 Michael M, Babic B, Khokha R, Tsao M, Ho J, Pintilie M, Leco K, Chamberlain D, Shepherd FA. Expression and prognostic significance of metalloproteinases and their tissue inhibitors in patients with small-cell lung cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 17: 1802-8. PMID 10561218 DOI: 10.1200/Jco.1999.17.6.1802  0.384
1999 Martin DC, Fowlkes JL, Babic B, Khokha R. Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1. The Journal of Cell Biology. 146: 881-92. PMID 10459021 DOI: 10.1083/Jcb.146.4.881  0.362
1999 Fata JE, Leco KJ, Moorehead RA, Martin DC, Khokha R. Timp-1 is important for epithelial proliferation and branching morphogenesis during mouse mammary development. Developmental Biology. 211: 238-54. PMID 10395785 DOI: 10.1006/Dbio.1999.9313  0.448
1999 Krüger A, Schirrmacher V, Khokha R. The bacterial lacZ gene: an important tool for metastasis research and evaluation of new cancer therapies. Cancer Metastasis Reviews. 17: 285-94. PMID 10352882 DOI: 10.1023/A:1006066706040  0.339
1998 Xu F, Carlos T, Li M, Sanchez-Sweatman O, Khokha R, Gorelik E. Inhibition of VLA-4 and up-regulation of TIMP-1 expression in B16BL6 melanoma cells transfected with MHC class I genes. Clinical & Experimental Metastasis. 16: 358-70. PMID 9626815 DOI: 10.1023/A:1006569631330  0.34
1997 Krüger A, Fata JE, Khokha R. Altered tumor growth and metastasis of a T-cell lymphoma in Timp-1 transgenic mice Blood. 90: 1993-2000. PMID 9292534 DOI: 10.1182/Blood.V90.5.1993  0.381
1997 Leco KJ, Apte SS, Taniguchi GT, Hawkes SP, Khokha R, Schultz GA, Edwards DR. Murine tissue inhibitor of metalloproteinases-4 (Timp-4): cDNA isolation and expression in adult mouse tissues. Febs Letters. 401: 213-7. PMID 9013889 DOI: 10.1016/S0014-5793(96)01474-3  0.324
1996 Sharmela Inderdeo D, Edwards DR, Han VKM, Khokha R. Temporal and spatial expression of tissue inhibitors of metalloproteinases during the natural ovulatory cycle of the mouse Biology of Reproduction. 55: 498-508. PMID 8862765 DOI: 10.1095/Biolreprod55.3.498  0.341
1996 Koop S, Schmidt EE, MacDonald IC, Morris VL, Khokha R, Grattan M, Leone J, Chambers AF, Groom AC. Independence of metastatic ability and extravasation: metastatic ras-transformed and control fibroblasts extravasate equally well. Proceedings of the National Academy of Sciences of the United States of America. 93: 11080-4. PMID 8855312 DOI: 10.1073/Pnas.93.20.11080  0.384
1996 Chambers AF, MacDonald IC, Schmidt EE, Koop S, Morris VL, Khokha R, Groom AC. Steps in tumor metastasis: new concepts from intravital videomicroscopy. Cancer Metastasis Reviews. 14: 279-301. PMID 8821091 DOI: 10.1007/Bf00690599  0.339
1995 Morris VL, Schmidt EE, Koop S, MacDonald IC, Grattan M, Khokha R, McLane MA, Niewiarowski S, Chambers AF, Groom AC. Effects of the disintegrin eristostatin on individual steps of hematogenous metastasis. Experimental Cell Research. 219: 571-8. PMID 7641809 DOI: 10.1006/Excr.1995.1266  0.414
1995 Khokha R, Martin DC, Fata JE. Utilization of transgenic mice in the study of matrix degrading proteinases and their inhibitors. Cancer Metastasis Reviews. 14: 97-111. PMID 7554034 DOI: 10.1007/Bf00665794  0.389
1994 Khokha R. Suppression of the tumorigenic and metastatic abilities of murine B16-F10 melanoma cells in vivo by the overexpression of the tissue inhibitor of the metalloproteinases-1. Journal of the National Cancer Institute. 86: 299-304. PMID 8158685 DOI: 10.1093/Jnci/86.4.299  0.372
1992 Khokha R, Zimmer MJ, Wilson SM, Chambers AF. Up-regulation of TIMP-1 expression in B16-F10 melanoma cells suppresses their metastatic ability in chick embryo. Clinical & Experimental Metastasis. 10: 365-70. PMID 1451346 DOI: 10.1007/Bf00133464  0.369
1992 Khokha R, Zimmer MJ, Graham CH, Lala PK, Waterhouse P. Suppression of invasion by inducible expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) in B16-F10 melanoma cells. Journal of the National Cancer Institute. 84: 1017-22. PMID 1318976 DOI: 10.1093/Jnci/84.13.1017  0.39
1991 Khokha R, Waterhouse P, Lala P, Zimmer M, Denhardt DT. Increased proteinase expression during tumor progression of cell lines down-modulated for TIMP levels: a new transformation paradigm? Journal of Cancer Research and Clinical Oncology. 117: 620. DOI: 10.1007/Bf01613299  0.37
1989 Yagel S, Khokha R, Denhardt DT, Kerbel RS, Parhar RS, Lala PK. Mechanisms of cellular invasiveness: A comparison of amnion invasion in vitro and metastatic behavior in vivo Journal of the National Cancer Institute. 81: 768-775. PMID 2541259 DOI: 10.1093/Jnci/81.10.768  0.384
1989 Khokha R, Waterhouse P, Yagel S, Lala PK, Overall CM, Norton G, Denhardt DT. Antisense RNA-induced reduction in murine TIMP levels confers oncogenicity on Swiss 3T3 cells Science. 243: 947-950. PMID 2465572 DOI: 10.1126/Science.2465572  0.325
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