| Year |
Citation |
Score |
| 2020 |
Cogan DP, Li X, Sevillano N, Mathews II, Matsui T, Craik CS, Khosla C. Antibody Probes of Module 1 of the 6-Deoxyerythronolide B Synthase Reveal an Extended Conformation During Ketoreduction. Journal of the American Chemical Society. 142: 14933-14939. PMID 32786753 DOI: 10.1021/Jacs.0C05133 |
0.36 |
|
| 2020 |
Gupta A, Ökesli-Armlovich A, Morgens D, Bassik MC, Khosla C. Genome-wide analysis of targets of macrolide antibiotics in mammalian cells. The Journal of Biological Chemistry. PMID 31915244 DOI: 10.1074/Jbc.Ra119.010770 |
0.32 |
|
| 2019 |
Zhuang R, Khosla C. Substrates, inhibitors, and probes of mammalian transglutaminase 2. Analytical Biochemistry. 591: 113560. PMID 31874171 DOI: 10.1016/J.Ab.2019.113560 |
0.392 |
|
| 2019 |
Nivina A, Yuet KP, Hsu J, Khosla C. Evolution and Diversity of Assembly-Line Polyketide Synthases. Chemical Reviews. PMID 31838842 DOI: 10.1021/Acs.Chemrev.9B00525 |
0.308 |
|
| 2019 |
Okesli-Armlovich A, Gupta A, Jimenez M, Auld D, Liu Q, Bassik MC, Khosla C. Discovery of small molecule inhibitors of human uridine-cytidine kinase 2 by high-throughput screening. Bioorganic & Medicinal Chemistry Letters. PMID 31420268 DOI: 10.1016/J.Bmcl.2019.08.010 |
0.318 |
|
| 2019 |
Sankaranarayanan K, Antaris XX, Palanski BA, El Gamal A, Kao CM, Fitch WL, Fischer CR, Khosla C. Tunable Enzymatic Synthesis of the Immunomodulator Lipid IV To Enable Structure-Activity Analysis. Journal of the American Chemical Society. PMID 31184877 DOI: 10.1021/Jacs.9B03066 |
0.364 |
|
| 2019 |
Melkonian AV, Weng N, Palanski BA, Khosla C. In Vivo Measurement of Redox-Regulated TG2 Activity. Methods in Molecular Biology (Clifton, N.J.). 1967: 263-274. PMID 31069776 DOI: 10.1007/978-1-4939-9187-7_16 |
0.327 |
|
| 2019 |
Klaus M, D'Souza AD, Nivina A, Khosla C, Grininger M. Engineering of Chimeric Polyketide Synthases Using SYNZIP Docking Domains. Acs Chemical Biology. PMID 30682239 DOI: 10.1021/Acschembio.8B01060 |
0.32 |
|
| 2018 |
Li X, Sevillano N, La Greca F, Hsu J, Mathews II, Matsui T, Craik CS, Khosla C. Discovery and characterization of a thioesterase-specific monoclonal antibody that recognizes the 6-deoxyerythronolide B synthase. Biochemistry. PMID 30289692 DOI: 10.1021/Acs.Biochem.8B00886 |
0.341 |
|
| 2018 |
Li X, Sevillano N, La Greca F, Deis L, Liu YC, Deller MC, Mathews II, Matsui T, Cane DE, Craik CS, Khosla C. Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module. Journal of the American Chemical Society. PMID 29762030 DOI: 10.1021/Jacs.8B02100 |
0.301 |
|
| 2018 |
Harvey CJB, Tang M, Schlecht U, Horecka J, Fischer CR, Lin HC, Li J, Naughton B, Cherry J, Miranda M, Li YF, Chu AM, Hennessy JR, Vandova GA, Inglis D, ... ... Khosla C, et al. HEx: A heterologous expression platform for the discovery of fungal natural products. Science Advances. 4: eaar5459. PMID 29651464 DOI: 10.1126/Sciadv.Aar5459 |
0.563 |
|
| 2018 |
Palanski BA, Khosla C. Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism. Biochemistry. PMID 29570977 DOI: 10.1021/Acs.Biochem.8B00204 |
0.315 |
|
| 2018 |
Yi MC, Melkonian AV, Ousey JA, Khosla C. Endoplasmic reticulum-resident protein 57 (ERp57) oxidatively inactivates human transglutaminase 2. The Journal of Biological Chemistry. PMID 29305423 DOI: 10.1074/Jbc.Ra117.001382 |
0.315 |
|
| 2018 |
Khosla C, Clark DS, Chen W. A tribute to Professor Jay Bailey: A pioneer in biochemical engineering Aiche Journal. 64: 4179-4181. DOI: 10.1002/Aic.16441 |
0.568 |
|
| 2017 |
Xie X, Garg A, Khosla C, Cane DE. Elucidation of the Cryptic Methyl Group Epimerase Activity of Dehydratase Domains from Modular Polyketide Synthases Using a Tandem Modules Epimerase Assay. Journal of the American Chemical Society. PMID 28682630 DOI: 10.1021/Jacs.7B05502 |
0.333 |
|
| 2017 |
Vandova GA, O'Brien RV, Lowry B, Robbins TF, Fischer CR, Davis RW, Khosla C, Harvey CJ, Hillenmeyer ME. Heterologous expression of diverse propionyl-CoA carboxylases affects polyketide production in Escherichia coli. The Journal of Antibiotics. PMID 28400575 DOI: 10.1038/Ja.2017.38 |
0.303 |
|
| 2017 |
Xie X, Garg A, Khosla C, Cane DE. Mechanism and Stereochemistry of Polyketide Chain Elongation and Methyl Group Epimerization in Polyether Biosynthesis. Journal of the American Chemical Society. PMID 28157306 DOI: 10.1021/Jacs.7B00278 |
0.327 |
|
| 2016 |
Plugis NM, Palanski BA, Weng CH, Albertelli M, Khosla C. Thioredoxin-1 Selectively Activates Transglutaminase 2 in the Extracellular Matrix of the Small Intestine: Implications for Celiac Disease. The Journal of Biological Chemistry. PMID 28003361 DOI: 10.1074/Jbc.M116.767988 |
0.314 |
|
| 2016 |
Robbins T, Kapilivsky J, Cane DE, Khosla C. Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase. Biochemistry. PMID 27441852 DOI: 10.1021/Acs.Biochem.6B00639 |
0.318 |
|
| 2016 |
Kuo J, Lynch SR, Liu CW, Xiao X, Khosla C. Partial In Vitro Reconstitution of an Orphan Polyketide Synthase Associated with Clinical Cases of Nocardiosis. Acs Chemical Biology. PMID 27384917 DOI: 10.1021/Acschembio.6B00489 |
0.354 |
|
| 2016 |
Robbins T, Liu YC, Cane DE, Khosla C. Structure and mechanism of assembly line polyketide synthases. Current Opinion in Structural Biology. 41: 10-18. PMID 27266330 DOI: 10.1016/J.Sbi.2016.05.009 |
0.333 |
|
| 2016 |
Klaus M, Ostrowski MP, Austerjost J, Robbins T, Lowry B, Cane DE, Khosla C. Protein Protein Interactions, not Substrate Recognition, Dominates the Turnover of Chimeric Assembly Line Polyketide Synthases. The Journal of Biological Chemistry. PMID 27246853 DOI: 10.1074/Jbc.M116.730531 |
0.408 |
|
| 2016 |
Ostrowski MP, Cane DE, Khosla C. Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases. The Journal of Antibiotics. PMID 27118242 DOI: 10.1038/Ja.2016.41 |
0.365 |
|
| 2016 |
Yi MC, Khosla C. Thiol-Disulfide Exchange Reactions in the Mammalian Extracellular Environment. Annual Review of Chemical and Biomolecular Engineering. PMID 27023663 DOI: 10.1146/Annurev-Chembioeng-080615-033553 |
0.331 |
|
| 2016 |
Lowry B, Li X, Robbins T, Cane DE, Khosla C. A Turnstile Mechanism for the Controlled Growth of Biosynthetic Intermediates on Assembly Line Polyketide Synthases. Acs Central Science. 2: 14-20. PMID 26878060 DOI: 10.1021/Acscentsci.5B00321 |
0.336 |
|
| 2016 |
Xie X, Garg A, Keatinge-Clay AT, Khosla C, Cane DE. The Epimerase and Reductase Activities of Polyketide Synthase Ketoreductase Domains Utilize the Same Conserved Tyrosine and Serine Residues. Biochemistry. PMID 26863427 DOI: 10.1021/Acs.Biochem.6B00024 |
0.316 |
|
| 2014 |
Garg A, Xie X, Keatinge-Clay A, Khosla C, Cane DE. Elucidation of the cryptic epimerase activity of redox-inactive ketoreductase domains from modular polyketide synthases by tandem equilibrium isotope exchange. Journal of the American Chemical Society. 136: 10190-3. PMID 25004372 DOI: 10.1021/Ja5056998 |
0.33 |
|
| 2014 |
Dunn BJ, Watts KR, Robbins T, Cane DE, Khosla C. Comparative analysis of the substrate specificity of trans- versus cis-acyltransferases of assembly line polyketide synthases. Biochemistry. 53: 3796-806. PMID 24871074 DOI: 10.1021/Bi5004316 |
0.361 |
|
| 2014 |
Khosla C, Herschlag D, Cane DE, Walsh CT. Assembly line polyketide synthases: mechanistic insights and unsolved problems. Biochemistry. 53: 2875-83. PMID 24779441 DOI: 10.1021/Bi500290T |
0.329 |
|
| 2014 |
Alvarez-Sieiro P, Martin MC, Redruello B, Del Rio B, Ladero V, Palanski BA, Khosla C, Fernandez M, Alvarez MA. Generation of food-grade recombinant Lactobacillus casei delivering Myxococcus xanthus prolyl endopeptidase. Applied Microbiology and Biotechnology. 98: 6689-700. PMID 24752841 DOI: 10.1007/S00253-014-5730-7 |
0.345 |
|
| 2014 |
Edwards AL, Matsui T, Weiss TM, Khosla C. Architectures of whole-module and bimodular proteins from the 6-deoxyerythronolide B synthase. Journal of Molecular Biology. 426: 2229-45. PMID 24704088 DOI: 10.1016/J.Jmb.2014.03.015 |
0.379 |
|
| 2014 |
Kuo J, Khosla C. The initiation ketosynthase (FabH) is the sole rate-limiting enzyme of the fatty acid synthase of Synechococcus sp. PCC 7002. Metabolic Engineering. 22: 53-9. PMID 24395007 DOI: 10.1016/J.Ymben.2013.12.008 |
0.352 |
|
| 2014 |
O'Brien RV, Davis RW, Khosla C, Hillenmeyer ME. Computational identification and analysis of orphan assembly-line polyketide synthases. The Journal of Antibiotics. 67: 89-97. PMID 24301183 DOI: 10.1038/Ja.2013.125 |
0.307 |
|
| 2013 |
Lowry B, Robbins T, Weng CH, O'Brien RV, Cane DE, Khosla C. In vitro reconstitution and analysis of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. 135: 16809-12. PMID 24161212 DOI: 10.1021/Ja409048K |
0.348 |
|
| 2013 |
Xiao X, Yu X, Khosla C. Metabolic flux between unsaturated and saturated fatty acids is controlled by the FabA:FabB ratio in the fully reconstituted fatty acid biosynthetic pathway of Escherichia coli. Biochemistry. 52: 8304-12. PMID 24147979 DOI: 10.1021/Bi401116N |
0.312 |
|
| 2013 |
Walker MC, Thuronyi BW, Charkoudian LK, Lowry B, Khosla C, Chang MC. Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways. Science (New York, N.Y.). 341: 1089-94. PMID 24009388 DOI: 10.1126/Science.1242345 |
0.692 |
|
| 2013 |
Walsh CT, O'Brien RV, Khosla C. Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds. Angewandte Chemie (International Ed. in English). 52: 7098-124. PMID 23729217 DOI: 10.1002/Anie.201208344 |
0.381 |
|
| 2013 |
Dunn BJ, Khosla C. Engineering the acyltransferase substrate specificity of assembly line polyketide synthases. Journal of the Royal Society, Interface / the Royal Society. 10: 20130297. PMID 23720536 DOI: 10.1098/Rsif.2013.0297 |
0.364 |
|
| 2013 |
You YO, Khosla C, Cane DE. Stereochemistry of reductions catalyzed by methyl-epimerizing ketoreductase domains of polyketide synthases. Journal of the American Chemical Society. 135: 7406-9. PMID 23659177 DOI: 10.1021/Ja4014776 |
0.332 |
|
| 2013 |
Dunn BJ, Cane DE, Khosla C. Mechanism and specificity of an acyltransferase domain from a modular polyketide synthase. Biochemistry. 52: 1839-41. PMID 23452124 DOI: 10.1021/Bi400185V |
0.364 |
|
| 2013 |
Fitzgerald JT, Charkoudian LK, Watts KR, Khosla C. Analysis and refactoring of the A-74528 biosynthetic pathway. Journal of the American Chemical Society. 135: 3752-5. PMID 23442197 DOI: 10.1021/Ja311579S |
0.7 |
|
| 2013 |
DiRaimondo TR, Plugis NM, Jin X, Khosla C. Selective inhibition of extracellular thioredoxin by asymmetric disulfides. Journal of Medicinal Chemistry. 56: 1301-10. PMID 23327656 DOI: 10.1021/Jm301775S |
0.334 |
|
| 2013 |
Walsh CT, O'Brien RV, Khosla C. Nichtproteinogene Aminosäurebausteine für Peptidgerüste aus nichtribosomalen Peptiden und hybriden Polyketiden Angewandte Chemie. 125: 7238-7265. DOI: 10.1002/Ange.201208344 |
0.309 |
|
| 2012 |
Klöck C, Khosla C. Regulation of the activities of the mammalian transglutaminase family of enzymes. Protein Science : a Publication of the Protein Society. 21: 1781-91. PMID 23011841 DOI: 10.1002/Pro.2162 |
0.37 |
|
| 2012 |
Harvey CJ, Puglisi JD, Pande VS, Cane DE, Khosla C. Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket. Journal of the American Chemical Society. 134: 12259-65. PMID 22741553 DOI: 10.1021/Ja304682Q |
0.363 |
|
| 2012 |
Yuzawa S, Kapur S, Cane DE, Khosla C. Role of a conserved arginine residue in linkers between the ketosynthase and acyltransferase domains of multimodular polyketide synthases. Biochemistry. 51: 3708-10. PMID 22509729 DOI: 10.1021/Bi300399U |
0.336 |
|
| 2012 |
Klöck C, Diraimondo TR, Khosla C. Role of transglutaminase 2 in celiac disease pathogenesis. Seminars in Immunopathology. 34: 513-22. PMID 22437759 DOI: 10.1007/S00281-012-0305-0 |
0.319 |
|
| 2012 |
Wang J, Jin X, Liu J, Khosla C, Xia J. Resolving multiple protein-peptide binding events: implication for HLA-DQ2 mediated antigen presentation in celiac disease. Chemistry, An Asian Journal. 7: 992-9. PMID 22411856 DOI: 10.1002/Asia.201101041 |
0.517 |
|
| 2012 |
Kapur S, Lowry B, Yuzawa S, Kenthirapalan S, Chen AY, Cane DE, Khosla C. Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation. Proceedings of the National Academy of Sciences of the United States of America. 109: 4110-5. PMID 22371562 DOI: 10.1073/Pnas.1118734109 |
0.364 |
|
| 2012 |
Wong FT, Khosla C. Combinatorial biosynthesis of polyketides--a perspective. Current Opinion in Chemical Biology. 16: 117-23. PMID 22342766 DOI: 10.1016/J.Cbpa.2012.01.018 |
0.315 |
|
| 2012 |
Dafik L, Albertelli M, Stamnaes J, Sollid LM, Khosla C. Activation and inhibition of transglutaminase 2 in mice. Plos One. 7: e30642. PMID 22319575 DOI: 10.1371/Journal.Pone.0030642 |
0.316 |
|
| 2012 |
Bethune MT, Khosla C. Oral enzyme therapy for celiac sprue. Methods in Enzymology. 502: 241-71. PMID 22208988 DOI: 10.1016/B978-0-12-416039-2.00013-6 |
0.69 |
|
| 2012 |
Khosla C, Caren R, Kao CM, McDaniel R, Wang SW. Evolutionally guided enzyme design. Biotechnology and Bioengineering. 52: 122-8. PMID 18629858 DOI: 10.1002/(Sici)1097-0290(19961005)52:1<122::Aid-Bit12>3.0.Co;2-Q |
0.319 |
|
| 2012 |
Charkoudian LK, Farrell BP, Khosla C. Natural product inhibitors of glucose-6-phosphate translocase Medchemcomm. 3: 926-931. DOI: 10.1039/C2Md20008B |
0.665 |
|
| 2011 |
Yu X, Liu T, Zhu F, Khosla C. In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 18643-8. PMID 22042840 DOI: 10.1073/Pnas.1110852108 |
0.32 |
|
| 2011 |
Fitzgerald JT, Ridley CP, Khosla C. Engineered biosynthesis of the antiparasitic agent frenolicin B and rationally designed analogs in a heterologous host. The Journal of Antibiotics. 64: 759-62. PMID 21934692 DOI: 10.1038/Ja.2011.86 |
0.368 |
|
| 2011 |
Jin X, Stamnaes J, Klöck C, DiRaimondo TR, Sollid LM, Khosla C. Activation of extracellular transglutaminase 2 by thioredoxin. The Journal of Biological Chemistry. 286: 37866-73. PMID 21908620 DOI: 10.1074/Jbc.M111.287490 |
0.308 |
|
| 2011 |
Szu PH, Govindarajan S, Meehan MJ, Das A, Nguyen DD, Dorrestein PC, Minshull J, Khosla C. Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase. Chemistry & Biology. 18: 1021-31. PMID 21867917 DOI: 10.1016/J.Chembiol.2011.07.015 |
0.543 |
|
| 2011 |
Javidpour P, Das A, Khosla C, Tsai SC. Structural and biochemical studies of the hedamycin type II polyketide ketoreductase (HedKR): molecular basis of stereo- and regiospecificities. Biochemistry. 50: 7426-39. PMID 21776967 DOI: 10.1021/Bi2006866 |
0.552 |
|
| 2011 |
Wong FT, Jin X, Mathews II, Cane DE, Khosla C. Structure and mechanism of the trans-acting acyltransferase from the disorazole synthase. Biochemistry. 50: 6539-48. PMID 21707057 DOI: 10.1021/Bi200632J |
0.371 |
|
| 2011 |
Charkoudian LK, Liu CW, Capone S, Kapur S, Cane DE, Togni A, Seebach D, Khosla C. Probing the interactions of an acyl carrier protein domain from the 6-deoxyerythronolide B synthase. Protein Science : a Publication of the Protein Society. 20: 1244-55. PMID 21563224 DOI: 10.1002/Pro.652 |
0.713 |
|
| 2011 |
Dafik L, Khosla C. Dihydroisoxazole analogs for labeling and visualization of catalytically active transglutaminase 2. Chemistry & Biology. 18: 58-66. PMID 21276939 DOI: 10.1016/J.Chembiol.2010.11.004 |
0.303 |
|
| 2011 |
Lee HY, Harvey CJ, Cane DE, Khosla C. Improved precursor-directed biosynthesis in E. coli via directed evolution. The Journal of Antibiotics. 64: 59-64. PMID 21081955 DOI: 10.1038/Ja.2010.129 |
0.354 |
|
| 2011 |
Garber M, Siegel M, Khosla C, Voyksner J, Voyksner RD. Quantification of ALV003-Mediated Gluten Degradation Using Mass Spectrometry Gastroenterology. 140: S-642-S-643. DOI: 10.1016/S0016-5085(11)62661-9 |
0.442 |
|
| 2010 |
Kapur S, Chen AY, Cane DE, Khosla C. Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America. 107: 22066-71. PMID 21127271 DOI: 10.1073/Pnas.1014081107 |
0.361 |
|
| 2010 |
Charkoudian LK, Fitzgerald JT, Khosla C, Champlin A. In living color: bacterial pigments as an untapped resource in the classroom and beyond. Plos Biology. 8. PMID 20957190 DOI: 10.1371/Journal.Pbio.1000510 |
0.674 |
|
| 2010 |
Liu T, Khosla C. Genetic engineering of Escherichia coli for biofuel production. Annual Review of Genetics. 44: 53-69. PMID 20822440 DOI: 10.1146/Annurev-Genet-102209-163440 |
0.314 |
|
| 2010 |
Zaleta-Rivera K, Charkoudian LK, Ridley CP, Khosla C. Cloning, sequencing, heterologous expression, and mechanistic analysis of A-74528 biosynthesis. Journal of the American Chemical Society. 132: 9122-8. PMID 20550125 DOI: 10.1021/Ja102519V |
0.671 |
|
| 2010 |
Das A, Szu PH, Fitzgerald JT, Khosla C. Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis. Journal of the American Chemical Society. 132: 8831-3. PMID 20540492 DOI: 10.1021/Ja102517Q |
0.578 |
|
| 2010 |
Khosla C. Thematic minireview series on antibacterial natural products: new tricks for old dogs. The Journal of Biological Chemistry. 285: 27499. PMID 20522550 DOI: 10.1074/Jbc.R110.150417 |
0.363 |
|
| 2010 |
Tahanian E, Lord-Dufour S, Das A, Khosla C, Roy R, Annabi B. Inhibition of tubulogenesis and of carcinogen-mediated signaling in brain endothelial cells highlight the antiangiogenic properties of a mumbaistatin analog. Chemical Biology & Drug Design. 75: 481-8. PMID 20486934 DOI: 10.1111/J.1747-0285.2010.00961.X |
0.516 |
|
| 2010 |
Mazumdar K, Alvarez X, Borda JT, Dufour J, Martin E, Bethune MT, Khosla C, Sestak K. Visualization of transepithelial passage of the immunogenic 33-residue peptide from alpha-2 gliadin in gluten-sensitive macaques. Plos One. 5: e10228. PMID 20419103 DOI: 10.1371/Journal.Pone.0010228 |
0.67 |
|
| 2010 |
Liu T, Vora H, Khosla C. Quantitative analysis and engineering of fatty acid biosynthesis in E. coli. Metabolic Engineering. 12: 378-86. PMID 20184964 DOI: 10.1016/J.Ymben.2010.02.003 |
0.784 |
|
| 2010 |
Sealey-Voyksner JA, Khosla C, Voyksner RD, Jorgenson JW. Novel aspects of quantitation of immunogenic wheat gluten peptides by liquid chromatography-mass spectrometry/mass spectrometry. Journal of Chromatography. A. 1217: 4167-83. PMID 20181349 DOI: 10.1016/J.Chroma.2010.01.067 |
0.327 |
|
| 2010 |
Wong FT, Chen AY, Cane DE, Khosla C. Protein-protein recognition between acyltransferases and acyl carrier proteins in multimodular polyketide synthases. Biochemistry. 49: 95-102. PMID 19921859 DOI: 10.1021/Bi901826G |
0.351 |
|
| 2009 |
Das A, Khosla C. In vivo and in vitro analysis of the hedamycin polyketide synthase. Chemistry & Biology. 16: 1197-207. PMID 19942143 DOI: 10.1016/J.Chembiol.2009.11.005 |
0.554 |
|
| 2009 |
Valenzano CR, Lawson RJ, Chen AY, Khosla C, Cane DE. The biochemical basis for stereochemical control in polyketide biosynthesis. Journal of the American Chemical Society. 131: 18501-11. PMID 19928853 DOI: 10.1021/Ja908296M |
0.313 |
|
| 2009 |
Bethune MT, Crespo-Bosque M, Bergseng E, Mazumdar K, Doyle L, Sestak K, Sollid LM, Khosla C. Noninflammatory gluten peptide analogs as biomarkers for celiac sprue. Chemistry & Biology. 16: 868-81. PMID 19716477 DOI: 10.1016/j.chembiol.2009.07.009 |
0.648 |
|
| 2009 |
Khosla C. Structures and mechanisms of polyketide synthases. The Journal of Organic Chemistry. 74: 6416-20. PMID 19711990 DOI: 10.1021/Jo9012089 |
0.356 |
|
| 2009 |
Ehren J, Morón B, Martin E, Bethune MT, Gray GM, Khosla C. A food-grade enzyme preparation with modest gluten detoxification properties. Plos One. 4: e6313. PMID 19621078 DOI: 10.1371/Journal.Pone.0006313 |
0.805 |
|
| 2009 |
Das A, Khosla C. Biosynthesis of aromatic polyketides in bacteria. Accounts of Chemical Research. 42: 631-9. PMID 19292437 DOI: 10.1021/Ar8002249 |
0.604 |
|
| 2009 |
Bethune MT, Siegel M, Howles-Banerji S, Khosla C. Interferon-gamma released by gluten-stimulated celiac disease-specific intestinal T cells enhances the transepithelial flux of gluten peptides. The Journal of Pharmacology and Experimental Therapeutics. 329: 657-68. PMID 19218531 DOI: 10.1124/Jpet.108.148007 |
0.723 |
|
| 2009 |
Lord-Dufour S, Copland IB, Levros LC, Post M, Das A, Khosla C, Galipeau J, Rassart E, Annabi B. Evidence for transcriptional regulation of the glucose-6-phosphate transporter by HIF-1alpha: Targeting G6PT with mumbaistatin analogs in hypoxic mesenchymal stromal cells. Stem Cells (Dayton, Ohio). 27: 489-97. PMID 19074414 DOI: 10.1634/Stemcells.2008-0855 |
0.502 |
|
| 2009 |
Liu CW, Alekseyev VY, Allwardt JR, Bankovich AJ, Cade-Menun BJ, Davis RW, Du LS, Garcia KC, Herschlag D, Khosla C, Kraut DA, Li Q, Null B, Puglisi JD, Sigala PA, et al. The diversity of nuclear magnetic resonance spectroscopy Nato Science For Peace and Security Series B: Physics and Biophysics. 65-81. |
0.743 |
|
| 2008 |
Ehren J, Govindarajan S, Morón B, Minshull J, Khosla C. Protein engineering of improved prolyl endopeptidases for celiac sprue therapy. Protein Engineering, Design & Selection : Peds. 21: 699-707. PMID 18836204 DOI: 10.1093/Protein/Gzn050 |
0.772 |
|
| 2008 |
Lu X, Vora H, Khosla C. Overproduction of free fatty acids in E. coli: implications for biodiesel production. Metabolic Engineering. 10: 333-9. PMID 18812230 DOI: 10.1016/J.Ymben.2008.08.006 |
0.78 |
|
| 2008 |
Kapur S, Khosla C. Biochemistry: Fit for an enzyme. Nature. 454: 832-3. PMID 18704072 DOI: 10.1038/454832A |
0.324 |
|
| 2008 |
Castonguay R, Valenzano CR, Chen AY, Keatinge-Clay A, Khosla C, Cane DE. Stereospecificity of ketoreductase domains 1 and 2 of the tylactone modular polyketide synthase. Journal of the American Chemical Society. 130: 11598-9. PMID 18693734 DOI: 10.1021/Ja804453P |
0.3 |
|
| 2008 |
Yuan L, Behdad A, Siegel M, Khosla C, Higashikubo R, Rich KM. Tissue transgluaminase 2 expression in meningiomas. Journal of Neuro-Oncology. 90: 125-32. PMID 18587533 DOI: 10.1007/S11060-008-9642-1 |
0.446 |
|
| 2008 |
Morón B, Bethune MT, Comino I, Manyani H, Ferragud M, López MC, Cebolla A, Khosla C, Sousa C. Toward the assessment of food toxicity for celiac patients: characterization of monoclonal antibodies to a main immunogenic gluten peptide. Plos One. 3: e2294. PMID 18509534 DOI: 10.1371/Journal.Pone.0002294 |
0.66 |
|
| 2008 |
Bethune MT, Khosla C. Parallels between pathogens and gluten peptides in celiac sprue. Plos Pathogens. 4: e34. PMID 18425213 DOI: 10.1371/Journal.Ppat.0040034 |
0.691 |
|
| 2008 |
Siegel M, Strnad P, Watts RE, Choi K, Jabri B, Omary MB, Khosla C. Extracellular transglutaminase 2 is catalytically inactive, but is transiently activated upon tissue injury. Plos One. 3: e1861. PMID 18365016 DOI: 10.1371/Journal.Pone.0001861 |
0.488 |
|
| 2008 |
Bethune MT, Ribka E, Khosla C, Sestak K. Transepithelial transport and enzymatic detoxification of gluten in gluten-sensitive rhesus macaques. Plos One. 3: e1857. PMID 18365012 DOI: 10.1371/Journal.Pone.0001857 |
0.68 |
|
| 2008 |
Bethune MT, Borda JT, Ribka E, Liu MX, Phillippi-Falkenstein K, Jandacek RJ, Doxiadis GG, Gray GM, Khosla C, Sestak K. A non-human primate model for gluten sensitivity. Plos One. 3: e1614. PMID 18286171 DOI: 10.1371/Journal.Pone.0001614 |
0.645 |
|
| 2008 |
Kapur S, Worthington A, Tang Y, Cane DE, Burkart MD, Khosla C. Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. Bioorganic & Medicinal Chemistry Letters. 18: 3034-8. PMID 18243693 DOI: 10.1016/J.Bmcl.2008.01.073 |
0.535 |
|
| 2008 |
Ehren J, Khosla C. Oral glutenase therapy for celiac sprue Pediatric and Adolescent Medicine. 12: 148-156. DOI: 10.1159/000128996 |
0.702 |
|
| 2008 |
Watson P, Ding A, McMillan SA, Smye M, McClean E, Lawther H, Gallagher C, Riedel T, Vora H, Gass J, Khosla C, Gray GM. S1263 Implications of Enzymatic Detoxification of Food Gluten in Coeliac Disease Gastroenterology. 134: A-213. DOI: 10.1016/S0016-5085(08)60985-3 |
0.753 |
|
| 2008 |
Siegel M, Strnad P, Watts RE, Choi K, Jabri B, Adler G, Omary B, Khosla C. 1001 Extracellular Transglutaminase 2 Is Catalytically Inactive, But Is Transiently Activated Upon Tissue Injury in the Small Intestine Gastroenterology. 134: A-151. DOI: 10.1016/S0016-5085(08)60701-5 |
0.453 |
|
| 2008 |
Schnarr NA, Khosla C. Diversity-oriented Synthesis: Combinatorial Biosynthesis of Polyketides and Nonribosomal Peptides Chemical Biology: From Small Molecules to Systems Biology and Drug Design, Volume 1-3. 2: 519-536. DOI: 10.1002/9783527619375.ch9b |
0.732 |
|
| 2007 |
Pinkas DM, Strop P, Brunger AT, Khosla C. Transglutaminase 2 undergoes a large conformational change upon activation. Plos Biology. 5: e327. PMID 18092889 DOI: 10.1371/Journal.Pbio.0050327 |
0.353 |
|
| 2007 |
Castonguay R, He W, Chen AY, Khosla C, Cane DE. Stereospecificity of ketoreductase domains of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. 129: 13758-69. PMID 17918944 DOI: 10.1021/Ja0753290 |
0.349 |
|
| 2007 |
Alekseyev VY, Liu CW, Cane DE, Puglisi JD, Khosla C. Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase. Protein Science : a Publication of the Protein Society. 16: 2093-107. PMID 17893358 DOI: 10.1110/Ps.073011407 |
0.785 |
|
| 2007 |
Tang Y, Chen AY, Kim CY, Cane DE, Khosla C. Structural and mechanistic analysis of protein interactions in module 3 of the 6-deoxyerythronolide B synthase. Chemistry & Biology. 14: 931-43. PMID 17719492 DOI: 10.1016/J.Chembiol.2007.07.012 |
0.516 |
|
| 2007 |
Xia J, Bergseng E, Fleckenstein B, Siegel M, Kim CY, Khosla C, Sollid LM. Cyclic and dimeric gluten peptide analogues inhibiting DQ2-mediated antigen presentation in celiac disease. Bioorganic & Medicinal Chemistry. 15: 6565-73. PMID 17681795 DOI: 10.1016/J.Bmc.2007.07.001 |
0.625 |
|
| 2007 |
Gass J, Bethune MT, Siegel M, Spencer A, Khosla C. Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue. Gastroenterology. 133: 472-80. PMID 17681168 DOI: 10.1053/J.Gastro.2007.05.028 |
0.802 |
|
| 2007 |
Chen AY, Cane DE, Khosla C. Structure-based dissociation of a type I polyketide synthase module. Chemistry & Biology. 14: 784-92. PMID 17656315 DOI: 10.1016/J.Chembiol.2007.05.015 |
0.38 |
|
| 2007 |
Gass J, Vora H, Hofmann AF, Gray GM, Khosla C. Enhancement of dietary protein digestion by conjugated bile acids. Gastroenterology. 133: 16-23. PMID 17631126 DOI: 10.1053/J.Gastro.2007.04.008 |
0.781 |
|
| 2007 |
Siegel M, Xia J, Khosla C. Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2. Bioorganic & Medicinal Chemistry. 15: 6253-61. PMID 17590341 DOI: 10.1016/J.Bmc.2007.06.020 |
0.653 |
|
| 2007 |
Siegel M, Khosla C. Transglutaminase 2 inhibitors and their therapeutic role in disease states. Pharmacology & Therapeutics. 115: 232-45. PMID 17582505 DOI: 10.1016/J.Pharmthera.2007.05.003 |
0.528 |
|
| 2007 |
Lee TS, Das A, Khosla C. Structure-activity relationships of semisynthetic mumbaistatin analogs. Bioorganic & Medicinal Chemistry. 15: 5207-18. PMID 17524653 DOI: 10.1016/J.Bmc.2007.05.019 |
0.648 |
|
| 2007 |
Strnad P, Harada M, Siegel M, Terkeltaub RA, Graham RM, Khosla C, Omary MB. Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement. Gastroenterology. 132: 1515-26. PMID 17408647 DOI: 10.1053/J.Gastro.2007.02.020 |
0.451 |
|
| 2007 |
Vora H, McIntire J, Kumar P, Deshpande M, Khosla C. A scaleable manufacturing process for pro-EP-B2, a cysteine protease from barley indicated for celiac sprue. Biotechnology and Bioengineering. 98: 177-85. PMID 17385743 DOI: 10.1002/Bit.21423 |
0.796 |
|
| 2007 |
Khosla C, Tang Y, Chen AY, Schnarr NA, Cane DE. Structure and mechanism of the 6-deoxyerythronolide B synthase. Annual Review of Biochemistry. 76: 195-221. PMID 17328673 DOI: 10.1146/Annurev.Biochem.76.053105.093515 |
0.798 |
|
| 2007 |
Tse ML, Watts RE, Khosla C. Substrate tolerance of module 6 of the epothilone synthetase. Biochemistry. 46: 3385-93. PMID 17315981 DOI: 10.1021/Bi0616448 |
0.359 |
|
| 2007 |
Lee HY, Khosla C. Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli. Plos Biology. 5: e45. PMID 17298179 DOI: 10.1371/Journal.Pbio.0050045 |
0.32 |
|
| 2007 |
Ridley CP, Khosla C. Synthesis and biological activity of novel pyranopyrones derived from engineered aromatic polyketides. Acs Chemical Biology. 2: 104-8. PMID 17256996 DOI: 10.1021/Cb600382J |
0.319 |
|
| 2007 |
Yuan L, Siegel M, Choi K, Khosla C, Miller CR, Jackson EN, Piwnica-Worms D, Rich KM. Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy. Oncogene. 26: 2563-73. PMID 17099729 DOI: 10.1038/Sj.Onc.1210048 |
0.475 |
|
| 2007 |
Gass J, Vora H, Hofmann AF, Gray GM, Khosla C. WITHDRAWN: Enhancement of Dietary Protein Digestion by Conjugated Bile Acids Gastroenterology. DOI: 10.1053/J.Gastro.2007.04.030 |
0.778 |
|
| 2006 |
Schnarr NA, Khosla C. Trapping transient protein-protein interactions in polyketide biosynthesis. Acs Chemical Biology. 1: 679-80. PMID 17184129 DOI: 10.1021/Cb600451D |
0.751 |
|
| 2006 |
Watts RE, Siegel M, Khosla C. Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles. Journal of Medicinal Chemistry. 49: 7493-501. PMID 17149878 DOI: 10.1021/Jm060839A |
0.496 |
|
| 2006 |
Tang Y, Lee HY, Tang Y, Kim CY, Mathews I, Khosla C. Structural and functional studies on SCO1815: a beta-ketoacyl-acyl carrier protein reductase from Streptomyces coelicolor A3(2). Biochemistry. 45: 14085-93. PMID 17115703 DOI: 10.1021/Bi061187V |
0.611 |
|
| 2006 |
Rude MA, Khosla C. Production of ansamycin polyketide precursors in Escherichia coli. The Journal of Antibiotics. 59: 464-70. PMID 17080682 DOI: 10.1038/Ja.2006.65 |
0.788 |
|
| 2006 |
Tang Y, Kim CY, Mathews II, Cane DE, Khosla C. The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase. Proceedings of the National Academy of Sciences of the United States of America. 103: 11124-9. PMID 16844787 DOI: 10.1073/Pnas.0601924103 |
0.528 |
|
| 2006 |
Siegel M, Bethune MT, Gass J, Ehren J, Xia J, Johannsen A, Stuge TB, Gray GM, Lee PP, Khosla C. Rational design of combination enzyme therapy for celiac sprue. Chemistry & Biology. 13: 649-58. PMID 16793522 DOI: 10.1016/J.Chembiol.2006.04.009 |
0.784 |
|
| 2006 |
Bethune MT, Strop P, Tang Y, Sollid LM, Khosla C. Heterologous expression, purification, refolding, and structural-functional characterization of EP-B2, a self-activating barley cysteine endoprotease. Chemistry & Biology. 13: 637-47. PMID 16793521 DOI: 10.1016/J.Chembiol.2006.04.008 |
0.724 |
|
| 2006 |
Gass J, Vora H, Bethune MT, Gray GM, Khosla C. Effect of barley endoprotease EP-B2 on gluten digestion in the intact rat. The Journal of Pharmacology and Experimental Therapeutics. 318: 1178-86. PMID 16757540 DOI: 10.1124/Jpet.106.104315 |
0.78 |
|
| 2006 |
Hicks LM, Mazur MT, Miller LM, Dorrestein PC, Schnarr NA, Khosla C, Kelleher NL. Investigating nonribosomal peptide and polyketide biosynthesis by direct detection of intermediates on >70 kDa polypeptides by using Fourier-transform mass spectrometry. Chembiochem : a European Journal of Chemical Biology. 7: 904-7. PMID 16642537 DOI: 10.1002/Cbic.200500416 |
0.739 |
|
| 2006 |
Strnad P, Siegel M, Toivola DM, Choi K, Kosek JC, Khosla C, Omary MB. Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation. Febs Letters. 580: 2351--2357. PMID 16616523 DOI: 10.1016/J.Febslet.2006.03.051 |
0.458 |
|
| 2006 |
Chen AY, Schnarr NA, Kim CY, Cane DE, Khosla C. Extender unit and acyl carrier protein specificity of ketosynthase domains of the 6-deoxyerythronolide B synthase. Journal of the American Chemical Society. 128: 3067-74. PMID 16506788 DOI: 10.1021/Ja058093D |
0.779 |
|
| 2006 |
Xia J, Siegel M, Bergseng E, Sollid LM, Khosla C. Inhibition of HLA-DQ2-mediated antigen presentation by analogues of a high affinity 33-residue peptide from alpha2-gliadin. Journal of the American Chemical Society. 128: 1859-67. PMID 16464085 DOI: 10.1021/Ja056423O |
0.639 |
|
| 2006 |
He W, Wu J, Khosla C, Cane DE. Macrolactonization to 10-deoxymethynolide catalyzed by the recombinant thioesterase of the picromycin/methymycin polyketide synthase. Bioorganic & Medicinal Chemistry Letters. 16: 391-4. PMID 16249083 DOI: 10.1016/J.Bmcl.2005.09.077 |
0.341 |
|
| 2006 |
Moffet DA, Khosla C, Cane DE. Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2. Bioorganic & Medicinal Chemistry Letters. 16: 213-6. PMID 16213712 DOI: 10.1016/J.Bmcl.2005.09.017 |
0.338 |
|
| 2005 |
Lee TS, Khosla C, Tang Y. Orthogonal protein interactions in spore pigment producing and antibiotic producing polyketide synthases. The Journal of Antibiotics. 58: 663-6. PMID 16392683 DOI: 10.1038/Ja.2005.91 |
0.663 |
|
| 2005 |
Wu J, Zaleski TJ, Valenzano C, Khosla C, Cane DE. Polyketide double bond biosynthesis. Mechanistic analysis of the dehydratase-containing module 2 of the picromycin/methymycin polyketide synthase. Journal of the American Chemical Society. 127: 17393-404. PMID 16332089 DOI: 10.1021/Ja055672+ |
0.352 |
|
| 2005 |
Sollid LM, Khosla C. Future therapeutic options for celiac disease. Nature Clinical Practice. Gastroenterology & Hepatology. 2: 140-7. PMID 16265155 DOI: 10.1038/Ncpgasthep0111 |
0.358 |
|
| 2005 |
Wu J, He W, Khosla C, Cane DE. Chain elongation, macrolactonization, and hydrolysis of natural and reduced hexaketide substrates by the picromycin/methymycin polyketide synthase. Angewandte Chemie (International Ed. in English). 44: 7557-60. PMID 16247819 DOI: 10.1002/Anie.200502246 |
0.307 |
|
| 2005 |
Shan L, Qiao SW, Arentz-Hansen H, Molberg Ø, Gray GM, Sollid LM, Khosla C. Identification and analysis of multivalent proteolytically resistant peptides from gluten: implications for celiac sprue. Journal of Proteome Research. 4: 1732-41. PMID 16212427 DOI: 10.1021/Pr050173T |
0.606 |
|
| 2005 |
Pyle GG, Paaso B, Anderson BE, Allen DD, Marti T, Li Q, Siegel M, Khosla C, Gray GM. Effect of pretreatment of food gluten with prolyl endopeptidase on gluten-induced malabsorption in celiac sprue. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association. 3: 687-94. PMID 16206502 DOI: 10.1016/S1542-3565(05)00366-6 |
0.459 |
|
| 2005 |
Yuan L, Choi K, Khosla C, Zheng X, Higashikubo R, Chicoine MR, Rich KM. Tissue transglutaminase 2 inhibition promotes cell death and chemosensitivity in glioblastomas. Molecular Cancer Therapeutics. 4: 1293-302. PMID 16170020 DOI: 10.1158/1535-7163.Mct-04-0328 |
0.306 |
|
| 2005 |
Gass J, Ehren J, Strohmeier G, Isaacs I, Khosla C. Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy. Biotechnology and Bioengineering. 92: 674-84. PMID 16136593 DOI: 10.1002/Bit.20643 |
0.803 |
|
| 2005 |
Lee TS, Khosla C, Tang Y. Engineered biosynthesis of aklanonic acid analogues. Journal of the American Chemical Society. 127: 12254-62. PMID 16131203 DOI: 10.1021/Ja051429Z |
0.68 |
|
| 2005 |
Schnarr NA, Chen AY, Cane DE, Khosla C. Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry. Biochemistry. 44: 11836-42. PMID 16128585 DOI: 10.1021/Bi0510781 |
0.775 |
|
| 2005 |
Schnarr NA, Khosla C. Biological chemistry: just add chlorine. Nature. 436: 1094-5. PMID 16121161 DOI: 10.1038/4361094A |
0.753 |
|
| 2005 |
Hartung IV, Rude MA, Schnarr NA, Hunziker D, Khosla C. Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis. Journal of the American Chemical Society. 127: 11202-3. PMID 16089423 DOI: 10.1021/Ja051430Y |
0.792 |
|
| 2005 |
Choi K, Siegel M, Piper JL, Yuan L, Cho E, Strnad P, Omary B, Rich KM, Khosla C. Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2. Chemistry & Biology. 12: 469-75. PMID 15850984 DOI: 10.1016/J.Chembiol.2005.02.007 |
0.778 |
|
| 2005 |
Khosla C, Tang Y. Chemistry. A new route to designer antibiotics. Science (New York, N.Y.). 308: 367-8. PMID 15831747 DOI: 10.1126/Science.1111415 |
0.541 |
|
| 2005 |
Bergseng E, Xia J, Kim CY, Khosla C, Sollid LM. Main chain hydrogen bond interactions in the binding of proline-rich gluten peptides to the celiac disease-associated HLA-DQ2 molecule. The Journal of Biological Chemistry. 280: 21791-6. PMID 15826953 DOI: 10.1074/Jbc.M501558200 |
0.493 |
|
| 2005 |
Xia J, Sollid LM, Khosla C. Equilibrium and kinetic analysis of the unusual binding behavior of a highly immunogenic gluten peptide to HLA-DQ2. Biochemistry. 44: 4442-9. PMID 15766274 DOI: 10.1021/Bi047747C |
0.51 |
|
| 2005 |
Shan L, Mathews II, Khosla C. Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity. Proceedings of the National Academy of Sciences of the United States of America. 102: 3599-604. PMID 15738423 DOI: 10.1073/Pnas.0408286102 |
0.62 |
|
| 2005 |
Qiao SW, Piper J, Haraldsen G, Oynebråten I, Fleckenstein B, Molberg O, Khosla C, Sollid LM. Tissue transglutaminase-mediated formation and cleavage of histamine-gliadin complexes: biological effects and implications for celiac disease. Journal of Immunology (Baltimore, Md. : 1950). 174: 1657-63. PMID 15661929 DOI: 10.4049/Jimmunol.174.3.1657 |
0.766 |
|
| 2005 |
Marti T, Molberg Ø, Li Q, Gray GM, Khosla C, Sollid LM. Prolyl endopeptidase-mediated destruction of T cell epitopes in whole gluten: Chemical and immunological characterization Journal of Pharmacology and Experimental Therapeutics. 312: 19-26. PMID 15358813 DOI: 10.1124/Jpet.104.073312 |
0.344 |
|
| 2004 |
Wu J, Kinoshita K, Khosla C, Cane DE. Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase. Biochemistry. 43: 16301-10. PMID 15610024 DOI: 10.1021/Bi048147G |
0.332 |
|
| 2004 |
Diacovich L, Mitchell DL, Pham H, Gago G, Melgar MM, Khosla C, Gramajo H, Tsai SC. Crystal structure of the β-subunit of acyl-CoA carboxylase: Structure-based engineering of substrate specificity Biochemistry. 43: 14027-14036. PMID 15518551 DOI: 10.1021/Bi049065V |
0.373 |
|
| 2004 |
Kim CY, Alekseyev VY, Chen AY, Tang Y, Cane DE, Khosla C. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase. Biochemistry. 43: 13892-8. PMID 15518537 DOI: 10.1021/Bi048418N |
0.803 |
|
| 2004 |
Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S. Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway. Journal of the American Chemical Society. 126: 9924-5. PMID 15303858 DOI: 10.1021/Ja048836F |
0.334 |
|
| 2004 |
Kumar P, Khosla C, Tang Y. Manipulation and analysis of polyketide synthases. Methods in Enzymology. 388: 269-93. PMID 15289078 DOI: 10.1016/S0076-6879(04)88023-6 |
0.648 |
|
| 2004 |
Qiao SW, Bergseng E, Molberg Ø, Xia J, Fleckenstein B, Khosla C, Sollid LM. Antigen presentation to celiac lesion-derived T cells of a 33-mer gliadin peptide naturally formed by gastrointestinal digestion. Journal of Immunology (Baltimore, Md. : 1950). 173: 1757-62. PMID 15265905 DOI: 10.4049/Jimmunol.173.3.1757 |
0.51 |
|
| 2004 |
Tang Y, Koppisch AT, Khosla C. The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units. Biochemistry. 43: 9546-55. PMID 15260498 DOI: 10.1021/Bi049157K |
0.592 |
|
| 2004 |
Shan L, Marti T, Sollid LM, Gray GM, Khosla C. Comparative biochemical analysis of three bacterial prolyl endopeptidases: implications for coeliac sprue. The Biochemical Journal. 383: 311-8. PMID 15245330 DOI: 10.1042/Bj20040907 |
0.627 |
|
| 2004 |
Boddy CN, Hotta K, Tse ML, Watts RE, Khosla C. Precursor-directed biosynthesis of epothilone in Escherichia coli. Journal of the American Chemical Society. 126: 7436-7. PMID 15198579 DOI: 10.1021/Ja048108S |
0.657 |
|
| 2004 |
Piper JL, Gray GM, Khosla C. Effect of prolyl endopeptidase on digestive-resistant gliadin peptides in vivo. The Journal of Pharmacology and Experimental Therapeutics. 311: 213-9. PMID 15143130 DOI: 10.1124/Jpet.104.068429 |
0.748 |
|
| 2004 |
Kim CY, Quarsten H, Bergseng E, Khosla C, Sollid LM. Structural basis for HLA-DQ2-mediated presentation of gluten epitopes in celiac disease. Proceedings of the National Academy of Sciences of the United States of America. 101: 4175-9. PMID 15020763 DOI: 10.1073/Pnas.0306885101 |
0.322 |
|
| 2004 |
Tang Y, Lee TS, Khosla C. Engineered biosynthesis of regioselectively modified aromatic polyketides using bimodular polyketide synthases. Plos Biology. 2: E31. PMID 14966533 DOI: 10.1371/Journal.Pbio.0020031 |
0.682 |
|
| 2004 |
Khosla C, Keasling JD. Metabolic engineering for drug discovery and development. Nature Reviews. Drug Discovery. 2: 1019-25. PMID 14654799 DOI: 10.1038/Nrd1256 |
0.301 |
|
| 2004 |
Tang Y, Lee TS, Lee HY, Khosla C. Exploring the biosynthetic potential of bimodular aromatic polyketide synthases Tetrahedron. 60: 7659-7671. DOI: 10.1016/J.Tet.2004.05.118 |
0.685 |
|
| 2004 |
Rude MA, Khosla C. Engineered biosynthesis of polyketides in heterologous hosts Chemical Engineering Science. 59: 4693-4701. DOI: 10.1016/J.Ces.2004.09.026 |
0.797 |
|
| 2003 |
Kumar P, Koppisch AT, Cane DE, Khosla C. Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase. Journal of the American Chemical Society. 125: 14307-12. PMID 14624579 DOI: 10.1021/Ja037429L |
0.53 |
|
| 2003 |
Watanabe K, Khosla C, Stroud RM, Tsai SC. Crystal structure of an Acyl-ACP dehydrogenase from the FK520 polyketide biosynthetic pathway: insights into extender unit biosynthesis. Journal of Molecular Biology. 334: 435-44. PMID 14623185 DOI: 10.1016/J.Jmb.2003.10.021 |
0.459 |
|
| 2003 |
Pfeifer BA, Wang CC, Walsh CT, Khosla C. Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Applied and Environmental Microbiology. 69: 6698-702. PMID 14602630 DOI: 10.1128/Aem.69.11.6698-6702.2003 |
0.676 |
|
| 2003 |
Admiraal SJ, Khosla C, Walsh CT. A Switch for the transfer of substrate between nonribosomal peptide and polyketide modules of the rifamycin synthetase assembly line. Journal of the American Chemical Society. 125: 13664-5. PMID 14599196 DOI: 10.1021/Ja0379060 |
0.327 |
|
| 2003 |
Tang Y, Tsai SC, Khosla C. Polyketide chain length control by chain length factor. Journal of the American Chemical Society. 125: 12708-9. PMID 14558809 DOI: 10.1021/Ja0378759 |
0.571 |
|
| 2003 |
Kinoshita K, Pfeifer BA, Khosla C, Cane DE. Precursor-Directed polyketide biosynthesis in Escherichia coli. Bioorganic & Medicinal Chemistry Letters. 13: 3701-4. PMID 14552761 DOI: 10.1016/J.Bmcl.2003.08.008 |
0.614 |
|
| 2003 |
Koppisch AT, Khosla C. Structure-based mutagenesis of the malonyl-CoA:acyl carrier protein transacylase from Streptomyces coelicolor. Biochemistry. 42: 11057-64. PMID 12974642 DOI: 10.1021/Bi0349672 |
0.364 |
|
| 2003 |
Watanabe K, Wang CC, Boddy CN, Cane DE, Khosla C. Understanding substrate specificity of polyketide synthase modules by generating hybrid multimodular synthases. The Journal of Biological Chemistry. 278: 42020-6. PMID 12923197 DOI: 10.1074/Jbc.M305339200 |
0.748 |
|
| 2003 |
Hu Z, Pfeifer BA, Chao E, Murli S, Kealey J, Carney JR, Ashley G, Khosla C, Hutchinson CR. A specific role of the Saccharopolyspora erythraea thioesterase II gene in the function of modular polyketide synthases. Microbiology (Reading, England). 149: 2213-25. PMID 12904561 DOI: 10.1099/Mic.0.26015-0 |
0.612 |
|
| 2003 |
Watanabe K, Rude MA, Walsh CT, Khosla C. Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 100: 9774-8. PMID 12888623 DOI: 10.1073/Pnas.1632167100 |
0.808 |
|
| 2003 |
Tang Y, Lee TS, Kobayashi S, Khosla C. Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity. Biochemistry. 42: 6588-95. PMID 12767243 DOI: 10.1021/Bi0341962 |
0.697 |
|
| 2003 |
Yin Y, Lu H, Khosla C, Cane DE. Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase. Journal of the American Chemical Society. 125: 5671-6. PMID 12733905 DOI: 10.1021/Ja034574Q |
0.358 |
|
| 2003 |
Hans M, Hornung A, Dziarnowski A, Cane DE, Khosla C. Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules. Journal of the American Chemical Society. 125: 5366-74. PMID 12720450 DOI: 10.1021/Ja029539I |
0.35 |
|
| 2003 |
Liou GF, Khosla C. Building-block selectivity of polyketide synthases. Current Opinion in Chemical Biology. 7: 279-84. PMID 12714062 DOI: 10.1016/S1367-5931(03)00016-4 |
0.791 |
|
| 2003 |
Li Q, Khosla C, Puglisi JD, Liu CW. Solution structure and backbone dynamics of the holo form of the frenolicin acyl carrier protein. Biochemistry. 42: 4648-57. PMID 12705828 DOI: 10.1021/Bi0274120 |
0.327 |
|
| 2003 |
Hausch F, Halttunen T, Mäki M, Khosla C. Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase. Chemistry & Biology. 10: 225-31. PMID 12670536 DOI: 10.1016/S1074-5521(03)00045-0 |
0.329 |
|
| 2003 |
Kumar P, Li Q, Cane DE, Khosla C. Intermodular communication in modular polyketide synthases: structural and mutational analysis of linker mediated protein-protein recognition. Journal of the American Chemical Society. 125: 4097-102. PMID 12670230 DOI: 10.1021/Ja0297537 |
0.52 |
|
| 2003 |
Boddy CN, Schneider TL, Hotta K, Walsh CT, Khosla C. Epothilone C macrolactonization and hydrolysis are catalyzed by the isolated thioesterase domain of epothilone polyketide synthase. Journal of the American Chemical Society. 125: 3428-9. PMID 12643694 DOI: 10.1021/Ja0298646 |
0.627 |
|
| 2003 |
Keatinge-Clay AT, Shelat AA, Savage DF, Tsai SC, Miercke LJ, O'Connell JD, Khosla C, Stroud RM. Catalysis, specificity, and ACP docking site of Streptomyces coelicolor malonyl-CoA:ACP transacylase. Structure (London, England : 1993). 11: 147-54. PMID 12575934 DOI: 10.1016/S0969-2126(03)00004-2 |
0.375 |
|
| 2003 |
Liou GF, Lau J, Cane DE, Khosla C. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases. Biochemistry. 42: 200-7. PMID 12515555 DOI: 10.1021/Bi0268100 |
0.796 |
|
| 2003 |
Kinoshita K, Khosla C, Cane DE. Precursor-Directed Biosynthesis: Stereospecificity for Branched-Chain Diketides of the β-Ketoacyl-ACP Synthase Domain 2 of 6-Deoxyerythronolide B Synthase Helvetica Chimica Acta. 86: 3889-3907. DOI: 10.1002/Hlca.200390327 |
0.311 |
|
| 2002 |
Pan H, Tsai Sc, Meadows ES, Miercke LJ, Keatinge-Clay AT, O'Connell J, Khosla C, Stroud RM. Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway. Structure (London, England : 1993). 10: 1559-68. PMID 12429097 DOI: 10.1016/S0969-2126(02)00889-4 |
0.305 |
|
| 2002 |
Tsai SC, Lu H, Cane DE, Khosla C, Stroud RM. Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases. Biochemistry. 41: 12598-606. PMID 12379102 DOI: 10.1021/Bi0260177 |
0.322 |
|
| 2002 |
Lu H, Tsai SC, Khosla C, Cane DE. Expression, site-directed mutagenesis, and steady state kinetic analysis of the terminal thioesterase domain of the methymycin/picromycin polyketide synthase. Biochemistry. 41: 12590-7. PMID 12379101 DOI: 10.1021/Bi026006D |
0.355 |
|
| 2002 |
Shan L, Molberg Ø, Parrot I, Hausch F, Filiz F, Gray GM, Sollid LM, Khosla C. Structural basis for gluten intolerance in celiac sprue. Science (New York, N.Y.). 297: 2275-9. PMID 12351792 DOI: 10.1126/Science.1074129 |
0.614 |
|
| 2002 |
Parrot I, Huang PC, Khosla C. Circular dichroism and nuclear magnetic resonance spectroscopic analysis of immunogenic gluten peptides and their analogs. The Journal of Biological Chemistry. 277: 45572-8. PMID 12324465 DOI: 10.1074/Jbc.M207606200 |
0.369 |
|
| 2002 |
Hausch F, Shan L, Santiago NA, Gray GM, Khosla C. Intestinal digestive resistance of immunodominant gliadin peptides. American Journal of Physiology. Gastrointestinal and Liver Physiology. 283: G996-G1003. PMID 12223360 DOI: 10.1152/Ajpgi.00136.2002 |
0.608 |
|
| 2002 |
Pfeifer B, Hu Z, Licari P, Khosla C. Process and metabolic strategies for improved production of Escherichia coli-derived 6-deoxyerythronolide B. Applied and Environmental Microbiology. 68: 3287-92. PMID 12089005 DOI: 10.1128/Aem.68.7.3287-3292.2002 |
0.608 |
|
| 2002 |
Diacovich L, Peirú S, Kurth D, Rodríguez E, Podestá F, Khosla C, Gramajo H. Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2). Journal of Biological Chemistry. 277: 31228-31236. PMID 12048195 DOI: 10.1074/Jbc.M203263200 |
0.314 |
|
| 2002 |
Admiraal SJ, Khosla C, Walsh CT. The loading and initial elongation modules of rifamycin synthetase collaborate to produce mixed aryl ketide products. Biochemistry. 41: 5313-24. PMID 11955082 DOI: 10.1021/Bi0200312 |
0.334 |
|
| 2002 |
Dayem LC, Carney JR, Santi DV, Pfeifer BA, Khosla C, Kealey JT. Metabolic engineering of a methylmalonyl-CoA mutase-epimerase pathway for complex polyketide biosynthesis in Escherichia coli. Biochemistry. 41: 5193-201. PMID 11955068 DOI: 10.1021/Bi015593K |
0.615 |
|
| 2002 |
Wu N, Cane DE, Khosla C. Quantitative analysis of the relative contributions of donor acyl carrier proteins, acceptor ketosynthases, and linker regions to intermodular transfer of intermediates in hybrid polyketide synthases. Biochemistry. 41: 5056-66. PMID 11939803 DOI: 10.1021/Bi012086U |
0.594 |
|
| 2002 |
Cane DE, Kudo F, Kinoshita K, Khosla C. Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides. Chemistry & Biology. 9: 131-42. PMID 11841945 DOI: 10.1016/S1074-5521(02)00089-3 |
0.339 |
|
| 2002 |
McDaniel R, Licari P, Khosla C. Process development and metabolic engineering for the overproduction of natural and unnatural polyketides. Advances in Biochemical Engineering/Biotechnology. 73: 31-52. PMID 11816811 DOI: 10.1007/3-540-45300-8_3 |
0.312 |
|
| 2002 |
Piper JL, Gray GM, Khosla C. High selectivity of human tissue transglutaminase for immunoactive gliadin peptides: implications for celiac sprue. Biochemistry. 41: 386-93. PMID 11772038 DOI: 10.1021/Bi011715X |
0.779 |
|
| 2001 |
Tsai SC, Miercke LJ, Krucinski J, Gokhale R, Chen JC, Foster PG, Cane DE, Khosla C, Stroud RM. Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel. Proceedings of the National Academy of Sciences of the United States of America. 98: 14808-13. PMID 11752428 DOI: 10.1073/Pnas.011399198 |
0.363 |
|
| 2001 |
Meadows ES, Khosla C. In vitro reconstitution and analysis of the chain initiating enzymes of the R1128 polyketide synthase Biochemistry. 40: 14855-14861. PMID 11732905 DOI: 10.1021/Bi0113723 |
0.378 |
|
| 2001 |
Dreier J, Li Q, Khosla C. Malonyl-CoA:ACP transacylase from Streptomyces coelicolor has two alternative catalytically active nucleophiles. Biochemistry. 40: 12407-12411. PMID 11591161 DOI: 10.1021/Bi011108+ |
0.339 |
|
| 2001 |
Lombó F, Pfeifer B, Leaf T, Ou S, Kim YS, Cane DE, Licari P, Khosla C. Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering. Biotechnology Progress. 17: 612-7. PMID 11485419 DOI: 10.1021/Bp010045J |
0.632 |
|
| 2001 |
Kinoshita K, Williard PG, Khosla C, Cane DE. Precursor-directed biosynthesis of 16-membered macrolides by the erythromycin polyketide synthase. Journal of the American Chemical Society. 123: 2495-502. PMID 11456917 DOI: 10.1021/Ja004139L |
0.318 |
|
| 2001 |
Chiu HT, Hubbard BK, Shah AN, Eide J, Fredenburg RA, Walsh CT, Khosla C. Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 98: 8548-53. PMID 11447274 DOI: 10.1073/Pnas.151246498 |
0.387 |
|
| 2001 |
Wu N, Tsuji SY, Cane DE, Khosla C. Assessing the balance between protein-protein interactions and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules. Journal of the American Chemical Society. 123: 6465-74. PMID 11439032 DOI: 10.1021/Ja010219T |
0.792 |
|
| 2001 |
Salomon AR, Zhang Y, Seto H, Khosla C. Structure-activity relationships within a family of selectively cytotoxic macrolide natural products. Organic Letters. 3: 57-9. PMID 11429871 DOI: 10.1021/Ol006767D |
0.663 |
|
| 2001 |
Yin Y, Gokhale R, Khosla C, Cane DE. Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase. Bioorganic & Medicinal Chemistry Letters. 11: 1477-9. PMID 11412964 DOI: 10.1016/S0960-894X(00)00529-1 |
0.326 |
|
| 2001 |
Pohl NL, Hans M, Lee HY, Kim YS, Cane DE, Khosla C. Remarkably broad substrate tolerance of malonyl-CoA synthetase, an enzyme capable of intracellular synthesis of polyketide precursors. Journal of the American Chemical Society. 123: 5822-3. PMID 11403625 DOI: 10.1021/Ja0028368 |
0.333 |
|
| 2001 |
Admiraal SJ, Walsh CT, Khosla C. The loading module of rifamycin synthetase is an adenylation-thiolation didomain with substrate tolerance for substituted benzoates. Biochemistry. 40: 6116-23. PMID 11352749 DOI: 10.1021/Bi010080Z |
0.321 |
|
| 2001 |
Tsuji SY, Cane DE, Khosla C. Selective protein-protein interactions direct channeling of intermediates between polyketide synthase modules. Biochemistry. 40: 2326-31. PMID 11327852 DOI: 10.1021/Bi002463N |
0.802 |
|
| 2001 |
Tsuji SY, Wu N, Khosla C. Intermodular communication in polyketide synthases: comparing the role of protein-protein interactions to those in other multidomain proteins. Biochemistry. 40: 2317-25. PMID 11327851 DOI: 10.1021/Bi002462V |
0.787 |
|
| 2001 |
Pfeifer BA, Khosla C. Biosynthesis of polyketides in heterologous hosts. Microbiology and Molecular Biology Reviews : Mmbr. 65: 106-18. PMID 11238987 DOI: 10.1128/Mmbr.65.1.106-118.2001 |
0.602 |
|
| 2001 |
Pfeifer BA, Admiraal SJ, Gramajo H, Cane DE, Khosla C. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science (New York, N.Y.). 291: 1790-2. PMID 11230695 DOI: 10.1126/Science.1058092 |
0.612 |
|
| 2001 |
Salomon AR, Voehringer DW, Herzenberg LA, Khosla C. Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chemistry & Biology. 8: 71-80. PMID 11182320 DOI: 10.1016/S1074-5521(00)00057-0 |
0.647 |
|
| 2000 |
Salomon AR, Voehringer DW, Herzenberg LA, Khosla C. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Proceedings of the National Academy of Sciences of the United States of America. 97: 14766-71. PMID 11121076 DOI: 10.1073/Pnas.97.26.14766 |
0.641 |
|
| 2000 |
Lau J, Cane DE, Khosla C. Substrate specificity of the loading didomain of the erythromycin polyketide synthase. Biochemistry. 39: 10514-20. PMID 10956042 DOI: 10.1021/Bi000602V |
0.6 |
|
| 2000 |
Marti T, Hu Z, Pohl NL, Shah AN, Khosla C. Cloning, nucleotide sequence, and heterologous expression of the biosynthetic gene cluster for R1128, a non-steroidal estrogen receptor antagonist. Insights into an unusual priming mechanism. The Journal of Biological Chemistry. 275: 33443-8. PMID 10931852 DOI: 10.1074/Jbc.M006766200 |
0.319 |
|
| 2000 |
Julien B, Shah S, Ziermann R, Goldman R, Katz L, Khosla C. Isolation and characterization of the epothilone biosynthetic gene cluster from Sorangium cellulosum. Gene. 249: 153-60. PMID 10831849 DOI: 10.1016/S0378-1119(00)00149-9 |
0.314 |
|
| 2000 |
Dreier J, Khosla C. Mechanistic analysis of a type II polyketide synthase. Role of conserved residues in the beta-ketoacyl synthase-chain length factor heterodimer. Biochemistry. 39: 2088-2095. PMID 10684659 DOI: 10.1021/Bi992121L |
0.343 |
|
| 2000 |
Gokhale RS, Khosla C. Role of linkers in communication between protein modules. Current Opinion in Chemical Biology. 4: 22-7. PMID 10679375 DOI: 10.1016/S1367-5931(99)00046-0 |
0.334 |
|
| 2000 |
Tang L, Shah S, Chung L, Carney J, Katz L, Khosla C, Julien B. Cloning and heterologous expression of the epothilone gene cluster. Science (New York, N.Y.). 287: 640-2. PMID 10649995 DOI: 10.1126/Science.287.5453.640 |
0.322 |
|
| 2000 |
Wu N, Kudo F, Cane DE, Khosla C. Analysis of the molecular recognition features of individual modules derived from the erythromycin polyketide synthase Journal of the American Chemical Society. 122: X. DOI: 10.1021/Ja000023D |
0.574 |
|
| 2000 |
Burson KK, Khosla C. Dissecting the Chain Length Specificity in Bacterial Aromatic Polyketide Synthases using Chimeric Genes Tetrahedron. 56: 9401-9408. DOI: 10.1016/S0040-4020(00)00824-3 |
0.332 |
|
| 1999 |
Richardson MT, Pohl NL, Kealey JT, Khosla C. Tolerance and specificity of recombinant 6-methylsalicyclic acid synthase. Metabolic Engineering. 1: 180-7. PMID 10935930 DOI: 10.1006/Mben.1999.0113 |
0.371 |
|
| 1999 |
Khosla C, Gokhale RS, Jacobsen JR, Cane DE. Tolerance and specificity of polyketide synthases. Annual Review of Biochemistry. 68: 219-53. PMID 10872449 DOI: 10.1146/Annurev.Biochem.68.1.219 |
0.365 |
|
| 1999 |
Hu Z, Hunziker D, Hutchinson CR, Khosla C. A host-vector system for analysis and manipulation of rifamycin polyketide biosynthesis in Amycolatopsis mediterranei. Microbiology (Reading, England). 145: 2335-41. PMID 10517586 DOI: 10.1099/00221287-145-9-2335 |
0.334 |
|
| 1999 |
Zawada RJ, Khosla C. Heterologous expression, purification, reconstitution and kinetic analysis of an extended type II polyketide synthase Chemistry & Biology. 6: 607-615. PMID 10467128 DOI: 10.1016/S1074-5521(99)80112-4 |
0.369 |
|
| 1999 |
Dreier J, Shah AN, Khosla C. Kinetic analysis of the actinorhodin aromatic polyketide synthase. Journal of Biological Chemistry. 274: 25108-25112. PMID 10455191 DOI: 10.1074/Jbc.274.35.25108 |
0.368 |
|
| 1999 |
Gokhale RS, Tsuji SY, Cane DE, Khosla C. Dissecting and exploiting intermodular communication in polyketide synthases. Science (New York, N.Y.). 284: 482-5. PMID 10205055 DOI: 10.1126/Science.284.5413.482 |
0.8 |
|
| 1999 |
Gokhale RS, Hunziker D, Cane DE, Khosla C. Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase. Chemistry & Biology. 6: 117-25. PMID 10021418 DOI: 10.1016/S1074-5521(99)80008-8 |
0.34 |
|
| 1999 |
Lau J, Fu H, Cane DE, Khosla C. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units. Biochemistry. 38: 1643-51. PMID 9931032 DOI: 10.1021/Bi9820311 |
0.612 |
|
| 1999 |
Hunziker D, Wu N, Kenoshita K, Cane DE, Khosla C. Precursor directed biosynthesis of novel 6-deoxyerythronolide B analogs containing non-natural oxygen substituents and reactive functionalities Tetrahedron Letters. 40: 635-638. DOI: 10.1016/S0040-4039(98)02507-6 |
0.527 |
|
| 1998 |
Jacobsen JR, Keatinge-Clay AT, Cane DE, Khosla C. Precursor-directed biosynthesis of 12-ethyl erythromycin. Bioorganic & Medicinal Chemistry. 6: 1171-7. PMID 9784859 DOI: 10.1016/S0968-0896(98)00081-9 |
0.362 |
|
| 1998 |
Cane DE, Walsh CT, Khosla C. Harnessing the biosynthetic code: combinations, permutations, and mutations. Science (New York, N.Y.). 282: 63-8. PMID 9756477 DOI: 10.1126/Science.282.5386.63 |
0.394 |
|
| 1998 |
Jacobsen JR, Cane DE, Khosla C. Spontaneous priming of a downstream module in 6-deoxyerythronolide B synthase leads to polyketide biosynthesis. Biochemistry. 37: 4928-34. PMID 9538011 DOI: 10.1021/Bi9729920 |
0.399 |
|
| 1998 |
Carreras CW, Khosla C. Purification And In Vitro Reconstitution Of The Essential Protein Components Of An Aromatic Polyketide Synthase Biochemistry. 37: 2084-2088. PMID 9518007 DOI: 10.1021/Bi972919+ |
0.381 |
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| 1998 |
Gokhale RS, Lau J, Cane DE, Khosla C. Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase. Biochemistry. 37: 2524-8. PMID 9485401 DOI: 10.1021/Bi971887N |
0.619 |
|
| 1998 |
Yu TW, Shen Y, McDaniel R, Floss HG, Khosla C, Hopwood DA, Moore BS. Engineered biosynthesis of novel polyketides from Streptomyces spore pigment polyketide synthases Journal of the American Chemical Society. 120: 7749-7759. DOI: 10.1021/Ja9803658 |
0.314 |
|
| 1997 |
Chuck JA, McPherson M, Huang H, Jacobsen JR, Khosla C, Cane DE. Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase. Chemistry & Biology. 4: 757-66. PMID 9375254 DOI: 10.1016/S1074-5521(97)90314-8 |
0.407 |
|
| 1997 |
McDaniel R, Kao CM, Hwang SJ, Khosla C. Engineered intermodular and intramodular polyketide synthase fusions. Chemistry & Biology. 4: 667-74. PMID 9331407 DOI: 10.1016/S1074-5521(97)90222-2 |
0.38 |
|
| 1997 |
Carreras CW, Gehring AM, Walsh CT, Khosla C. Utilization of enzymatically phosphopantetheinylated acyl carrier proteins and acetyl-acyl carrier proteins by the actinorhodin polyketide synthase. Biochemistry. 36: 11757-61. PMID 9305965 DOI: 10.1021/Bi971350+ |
0.398 |
|
| 1997 |
Fu H, Khosla C. Antibiotic activity of polyketide products derived from combinatorial biosynthesis: implications for directed evolution. Molecular Diversity. 1: 121-4. PMID 9237201 DOI: 10.1007/Bf01721327 |
0.352 |
|
| 1997 |
Jacobsen JR, Hutchinson CR, Cane DE, Khosla C. Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. Science (New York, N.Y.). 277: 367-9. PMID 9219693 DOI: 10.1126/Science.277.5324.367 |
0.377 |
|
| 1997 |
Zawada RJX, Khosla C. Domain analysis of the molecular recognition features of aromatic polyketide synthase subunits. Journal of Biological Chemistry. 272: 16184-16188. PMID 9195917 DOI: 10.1074/Jbc.272.26.16184 |
0.372 |
|
| 1997 |
Pieper R, Gokhale RS, Luo G, Cane DE, Khosla C. Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase. Biochemistry. 36: 1846-51. PMID 9048569 DOI: 10.1021/Bi962324Z |
0.411 |
|
| 1997 |
Kramer PJ, Zawada RJX, McDaniel R, Hutchinson CR, Hopwood DA, Khosla C. Rational design and engineered biosynthesis of a novel 18-carbon aromatic polyketide Journal of the American Chemical Society. 119: 635-639. DOI: 10.1021/Ja962888Q |
0.31 |
|
| 1997 |
Carreras CW, Pieper R, Khosla C. The chemistry and biology of fatty acid, polyketide, and nonribosomal peptide biosynthesis Topics in Current Chemistry. 188: 85-126. DOI: 10.1007/Bfb0119235 |
0.373 |
|
| 1996 |
Alvarez MA, Fu H, Khosla C, Hopwood DA, Bailey JE. Engineered biosynthesis of novel polyketides: properties of the whiE aromatase/cyclase. Nature Biotechnology. 14: 335-8. PMID 9630896 DOI: 10.1038/Nbt0396-335 |
0.516 |
|
| 1996 |
Tsukamoto N, Chuck JA, Luo G, Kao CM, Khosla C, Cane DE. 6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2. Biochemistry. 35: 15244-8. PMID 8952473 DOI: 10.1021/Bi961972F |
0.375 |
|
| 1996 |
Lambalot RH, Gehring AM, Flugel RS, Zuber P, LaCelle M, Marahiel MA, Reid R, Khosla C, Walsh CT. A new enzyme superfamily - the phosphopantetheinyl transferases. Chemistry & Biology. 3: 923-36. PMID 8939709 DOI: 10.1016/S1074-5521(96)90181-7 |
0.387 |
|
| 1996 |
Bedford D, Jacobsen JR, Luo G, Cane DE, Khosla C. A functional chimeric modular polyketide synthase generated via domain replacement Chemistry and Biology. 3: 827-831. PMID 8939701 DOI: 10.1016/S1074-5521(96)90068-X |
0.368 |
|
| 1996 |
Luo G, Pieper R, Rosa A, Khosla C, Cane DE. Erythromycin biosynthesis: Exploiting the catalytic versatility of the modular polyketide synthase Bioorganic and Medicinal Chemistry. 4: 995-999. PMID 8831969 DOI: 10.1016/0968-0896(96)00096-X |
0.315 |
|
| 1996 |
Kao CM, Pieper R, Cane DE, Khosla C. Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase Biochemistry. 35: 12363-12368. PMID 8823171 DOI: 10.1021/Bi9616312 |
0.37 |
|
| 1996 |
Khosla C, Zawada RJ. Generation of polyketide libraries via combinatorial biosynthesis. Trends in Biotechnology. 14: 335-41. PMID 8818287 DOI: 10.1016/0167-7799(96)10046-9 |
0.345 |
|
| 1996 |
Blanco G, Fu H, Mendez C, Khosla C, Salas JA. Deciphering the biosynthetic origin of the aglycone of the aureolic acid group of anti-tumor agents Chemistry & Biology. 3: 193-196. PMID 8807845 DOI: 10.1016/S1074-5521(96)90262-8 |
0.347 |
|
| 1996 |
Pieper R, Ebert-Khosla S, Cane D, Khosla C. Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates. Biochemistry. 35: 2054-60. PMID 8652546 DOI: 10.1021/Bi952860B |
0.353 |
|
| 1996 |
Fu H, Alvarez MA, Khosla C, Bailey JE. Engineered biosynthesis of novel polyketides: regiospecific methylation of an unnatural substrate by the tcmO O-methyltransferase. Biochemistry. 35: 6527-32. PMID 8639600 DOI: 10.1021/Bi952957Y |
0.525 |
|
| 1996 |
Pieper R, Kao C, Khosla C, Luo G, Cane DE. Specificity and versatility in erythromycin biosynthesis Chemical Society Reviews. 25: 297-302. DOI: 10.1039/Cs9962500297 |
0.317 |
|
| 1995 |
Tsoi CJ, Khosla C. Combinatorial biosynthesis of ‘unnatural’ natural products: the polyketide example Chemistry & Biology. 2: 355-362. PMID 9383437 DOI: 10.1016/1074-5521(95)90214-7 |
0.328 |
|
| 1995 |
McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C. Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits. Nature. 375: 549-54. PMID 7791871 DOI: 10.1038/375549A0 |
0.338 |
|
| 1995 |
Bedford DJ, Schweizer E, Hopwood DA, Khosla C. Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2). Journal of Bacteriology. 177: 4544-8. PMID 7635840 DOI: 10.1128/Jb.177.15.4544-4548.1995 |
0.305 |
|
| 1995 |
Pieper R, Luo G, Cane DE, Khosla C. Cell-free synthesis of polyketides by recombinant erythromycin polyketide synthases Nature. 378: 263-266. PMID 7477343 DOI: 10.1038/378263A0 |
0.392 |
|
| 1995 |
Pieper R, Luo G, Cane DE, Khosla C. Remarkably broad substrate specificity of a modular polyketide synthase in a cell-free system Journal of the American Chemical Society. 117: 11373-11374. DOI: 10.1021/Ja00150A049 |
0.303 |
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| 1994 |
Fu H, Hopwood DA, Khosla C. Engineered biosynthesis of novel polyketides: evidence for temporal, but not regiospecific, control of cyclization of an aromatic polyketide precursor Chemistry & Biology. 1: 205-210. PMID 9383392 DOI: 10.1016/1074-5521(94)90012-4 |
0.346 |
|
| 1994 |
Kao CM, Katz L, Khosla C. Engineered biosynthesis of a complete macrolactone in a heterologous host. Science (New York, N.Y.). 265: 509-12. PMID 8036492 DOI: 10.1126/Science.8036492 |
0.37 |
|
| 1994 |
McDaniel R, Ebert-Khosla S, Fu H, Hopwood DA, Khosla C. Engineered biosynthesis of novel polyketides: influence of a downstream enzyme on the catalytic specificity of a minimal aromatic polyketide synthase Proceedings of the National Academy of Sciences of the United States of America. 91: 11542-11546. PMID 7972098 DOI: 10.1073/Pnas.91.24.11542 |
0.41 |
|
| 1994 |
Caren R, Mørkeberg R, Khosla C. Efficient sampling of protein sequence space for multiple mutants. Bio/Technology (Nature Publishing Company). 12: 517-20. PMID 7764711 DOI: 10.1038/Nbt0594-517 |
0.316 |
|
| 1994 |
McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C. Engineered Biosynthesis of Novel Polyketides: actVII and actIV Genes Encode Aromatase and Cyclase Enzymes, Respectively Journal of the American Chemical Society. 116: 10855-10859. DOI: 10.1021/Ja00103A001 |
0.322 |
|
| 1994 |
Fu H, Ebert-Khosla S, Hopwood DA, Khosla C. Engineered Biosynthesis of Novel Polyketides: Dissection of the Catalytic Specificity of the act Ketoreductase Journal of the American Chemical Society. 116: 4166-4170. DOI: 10.1021/Ja00089A003 |
0.311 |
|
| 1993 |
Khosla C, McDaniel R, Ebert-Khosla S, Torres R, Sherman DH, Bibb MJ, Hopwood DA. Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins. Journal of Bacteriology. 175: 2197-204. PMID 8468280 DOI: 10.1128/Jb.175.8.2197-2204.1993 |
0.359 |
|
| 1993 |
McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C. Engineered biosynthesis of novel polyketides: manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities Journal of the American Chemical Society. 115: 11671-11675. DOI: 10.1021/Ja00078A002 |
0.334 |
|
| 1990 |
Bailey JE, Birnbaum S, Galazzo JL, Khosla C, Shanks JV. Strategies and challenges in metabolic engineering. Annals of the New York Academy of Sciences. 589: 1-15. PMID 2192652 DOI: 10.1111/J.1749-6632.1990.Tb24230.X |
0.654 |
|
| 1990 |
Khosla C, Curtis JE, Bydalek P, Swartz JR, Bailey JE. Expression of recombinant proteins in Escherichia coli using an oxygen-responsive promoter. Bio/Technology (Nature Publishing Company). 8: 554-8. PMID 1367436 DOI: 10.1038/Nbt0690-554 |
0.484 |
|
| 1990 |
Khosla C, Curtis JE, DeModena J, Rinas U, Bailey JE. Expression of intracellular hemoglobin improves protein synthesis in oxygen-limited Escherichia coli. Bio/Technology (Nature Publishing Company). 8: 849-53. PMID 1366796 DOI: 10.1038/Nbt0990-849 |
0.519 |
|
| 1989 |
Hughes DE, Curtis JE, Khosla C, Bailey JE. A new oxygen-regulated promoter for the expression of proteins in Escherichia coli. Biotechniques. 7: 1026-8. PMID 2698665 |
0.393 |
|
| 1989 |
Khosla C, Bailey JE. Evidence for partial export of Vitreoscilla hemoglobin into the periplasmic space in Escherichia coli. Implications for protein function. Journal of Molecular Biology. 210: 79-89. PMID 2685332 DOI: 10.1016/0022-2836(89)90292-1 |
0.509 |
|
| 1989 |
Khosla C, Bailey JE. Characterization of the oxygen-dependent promoter of the Vitreoscilla hemoglobin gene in Escherichia coli. Journal of Bacteriology. 171: 5995-6004. PMID 2681149 DOI: 10.1128/Jb.171.11.5995-6004.1989 |
0.462 |
|
| 1988 |
Khosla C, Bailey JE. Heterologous expression of a bacterial haemoglobin improves the growth properties of recombinant Escherichia coli. Nature. 331: 633-5. PMID 3277067 DOI: 10.1038/331633A0 |
0.472 |
|
| 1988 |
Khosla C, Bailey JE. The Vitreoscilla hemoglobin gene: molecular cloning, nucleotide sequence and genetic expression in Escherichia coli. Molecular & General Genetics : Mgg. 214: 158-61. PMID 3067078 DOI: 10.1007/Bf00340195 |
0.479 |
|
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