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Morag Park, Ph.D. - Publications

Molecular Oncology McGill University, Montreal, QC, Canada 
Signal Transduction

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Yu G, Li X, He TF, Gruosso T, Zuo D, Souleimanova M, Ramos VM, Omeroglu A, Meterissian S, Guiot MC, Yang L, Yuan Y, Park M, Lee PP, Levine H. Predicting Relapse in Patients With Triple Negative Breast Cancer (TNBC) Using a Deep-Learning Approach. Frontiers in Physiology. 11: 511071. PMID 33071806 DOI: 10.3389/fphys.2020.511071  0.32
2020 Zaoui K, Smith HW, Park M, Duhamel S. ARF6 controls RHOB targeting to endosomes regulating cancer cell invasion. Molecular & Cellular Oncology. 7: 1766932. PMID 32944628 DOI: 10.1080/23723556.2020.1766932  0.36
2019 Bell ES, Coelho PP, Ratcliffe CDH, Rajadurai CV, Peschard P, Vaillancourt R, Zuo D, Park M. LC3C-Mediated Autophagy Selectively Regulates the Met RTK and HGF-Stimulated Migration and Invasion. Cell Reports. 29: 4053-4068.e6. PMID 31851933 DOI: 10.1016/j.celrep.2019.11.063  0.44
2019 Hirukawa A, Singh S, Wang J, Rennhack JP, Swiatnicki M, Sanguin-Gendreau V, Zuo D, Daldoul K, Lavoie C, Park M, Andrechek ER, Westbrook TF, Harris LN, Varadan V, Smith HW, et al. Reduction of Global H3K27me Enhances HER2/ErbB2 Targeted Therapy. Cell Reports. 29: 249-257.e8. PMID 31597089 DOI: 10.1016/j.celrep.2019.08.105  0.32
2019 Zaoui K, Rajadurai CV, Duhamel S, Park M. Arf6 regulates RhoB subcellular localization to control cancer cell invasion. The Journal of Cell Biology. PMID 31591185 DOI: 10.1083/jcb.201806111  0.36
2019 Kong T, Xue Y, Cencic R, Zhu X, Monast A, Fu Z, Pilon V, Sangwan V, Guiot MC, Foulkes WD, Porco JA, Park M, Pelletier J, Huang S. eIF4A inhibitors suppress cell cycle feedback response and acquired resistance to CDK4/6 inhibition in cancer. Molecular Cancer Therapeutics. PMID 31395685 DOI: 10.1158/1535-7163.MCT-19-0162  0.32
2019 Smith HW, Hirukawa A, Sanguin-Gendreau V, Nandi I, Dufour CR, Zuo D, Tandoc K, Leibovitch M, Singh S, Rennhack JP, Swiatnicki M, Lavoie C, Papavasiliou V, Temps C, Carragher NO, ... ... Park M, et al. An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis. Nature Communications. 10: 2901. PMID 31263101 DOI: 10.1038/s41467-019-10681-4  0.4
2019 Gruosso T, Gigoux M, Manem VSK, Bertos N, Zuo D, Perlitch I, Saleh SMI, Zhao H, Souleimanova M, Johnson RM, Monette A, Ramos VM, Hallett MT, Stagg J, Lapointe R, ... ... Park M, et al. Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers. The Journal of Clinical Investigation. PMID 30753167 DOI: 10.1172/JCI96313  0.32
2019 Li X, Gruosso T, Zuo D, Omeroglu A, Meterissian S, Guiot MC, Salazar A, Park M, Levine H. Infiltration of CD8 T cells into tumor cell clusters in triple-negative breast cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 30733298 DOI: 10.1073/pnas.1817652116  0.32
2018 Zaoui K, Duhamel S, Parachoniak CA, Park M. CLIP-170 spatially modulates receptor tyrosine kinase recycling to coordinate cell migration. Traffic (Copenhagen, Denmark). PMID 30537020 DOI: 10.1111/tra.12629  0.64
2018 Hirukawa A, Smith HW, Zuo D, Dufour CR, Savage P, Bertos N, Johnson RM, Bui T, Bourque G, Basik M, Giguère V, Park M, Muller WJ. Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program. Nature Communications. 9: 2547. PMID 29959321 DOI: 10.1038/s41467-018-04864-8  0.32
2018 Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF. The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression. Cell Reports. 23: 1476-1490. PMID 29719259 DOI: 10.1016/j.celrep.2018.04.019  0.36
2018 Knight JF, Sung VYC, Kuzmin E, Couzens AL, de Verteuil DA, Ratcliffe CDH, Coelho PP, Johnson RM, Samavarchi-Tehrani P, Gruosso T, Smith HW, Lee W, Saleh SM, Zuo D, Zhao H, ... ... Park M, et al. KIBRA (WWC1) Is a Metastasis Suppressor Gene Affected by Chromosome 5q Loss in Triple-Negative Breast Cancer. Cell Reports. 22: 3191-3205. PMID 29562176 DOI: 10.1016/j.celrep.2018.02.095  0.32
2017 Savage P, Blanchet-Cohen A, Revil T, Badescu D, Saleh SMI, Wang YC, Zuo D, Liu L, Bertos NR, Munoz-Ramos V, Basik M, Petrecca K, Asselah J, Meterissian S, Guiot MC, ... ... Park M, et al. A Targetable EGFR-Dependent Tumor-Initiating Program in Breast Cancer. Cell Reports. 21: 1140-1149. PMID 29091754 DOI: 10.1016/j.celrep.2017.10.015  0.32
2016 Rajadurai CV, Havrylov S, Coelho PP, Ratcliffe CD, Zaoui K, Huang BH, Monast A, Chughtai N, Sangwan V, Gertler FB, Siegel PM, Park M. 5'-Inositol phosphatase SHIP2 recruits Mena to stabilize invadopodia for cancer cell invasion. The Journal of Cell Biology. PMID 27597754 DOI: 10.1083/jcb.201501003  0.36
2016 Jandaghi P, Najafabadi HS, Bauer AS, Papadakis AI, Fassan M, Hall A, Monast A, von Knebel Doeberitz M, Neoptolemos JP, Costello E, Greenhalf W, Scarpa A, Sipos B, Auld D, Lathrop M, ... Park M, et al. Expression of DRD2 is Increased in Human Pancreatic Ductal Adenocarcinoma and Inhibitors Slow Tumor Growth in Mice. Gastroenterology. PMID 27578530 DOI: 10.1053/j.gastro.2016.08.040  0.32
2016 Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V. ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer. Nature Communications. 7: 12156. PMID 27402251 DOI: 10.1038/ncomms12156  0.32
2016 Ratcliffe CD, Sahgal P, Parachoniak CA, Ivaska J, Park M. Regulation of cell migration and β1 integrin trafficking by the endosomal adaptor GGA3. Traffic (Copenhagen, Denmark). PMID 26935970 DOI: 10.1111/tra.12390  0.64
2016 Boulay PL, Mitchell L, Turpin J, Huot-Marchand JÉ, Lavoie C, Sanguin-Gendreau V, Jones L, Mitra S, Livingstone JM, Campbell S, Hallett M, Mills GB, Park M, Chodosh L, Strathdee D, et al. Rab11-FIP1C is a critical negative regulator in ErbB2-mediated mammary tumor progression. Cancer Research. PMID 26933086 DOI: 10.1158/0008-5472.CAN-15-2782  1
2015 Li J, Davidson D, Souza CM, Zhong MC, Wu N, Park M, Muller WJ, Veillette A. Loss of PTPN12 stimulates progression of ErbB2-dependent breast cancer by enhancing cell survival, migration and epithelial-to-mesenchymal transition. Molecular and Cellular Biology. PMID 26391955 DOI: 10.1128/MCB.00741-15  1
2015 Caserta E, Egriboz O, Wang H, Martin C, Koivisto C, Pecót T, Kladney RD, Shen C, Shim KS, Pham T, Karikomi MK, Mauntel MJ, Majumder S, Cuitino MC, Tang X, ... ... Park M, et al. Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo. Genes & Development. 29: 1707-20. PMID 26302789 DOI: 10.1101/gad.262568.115  1
2015 Oh EY, Christensen SM, Ghanta S, Jeong JC, Bucur O, Glass B, Montaser-Kouhsari L, Knoblauch NW, Bertos N, Saleh SM, Haibe-Kains B, Park M, Beck AH. Extensive rewiring of epithelial-stromal co-expression networks in breast cancer. Genome Biology. 16: 128. PMID 26087699 DOI: 10.1186/s13059-015-0675-4  1
2015 Mui MZ, Zhou Y, Blanchette P, Chughtai N, Knight JF, Gruosso T, Papadakis AI, Huang S, Park M, Gingras AC, Branton PE. The human adenovirus type 5 E4orf4 protein targets two phosphatase regulators of the Hippo signaling pathway. Journal of Virology. PMID 26085163 DOI: 10.1128/JVI.03710-14  1
2015 Li R, Knight JF, Park M, Pendergast AM. Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility. Plos One. 10: e0124960. PMID 25946048 DOI: 10.1371/journal.pone.0124960  1
2015 Tabariès S, Annis MG, Hsu BE, Tam CE, Savage P, Park M, Siegel PM. Lyn modulates Claudin-2 expression and is a therapeutic target for breast cancer liver metastasis. Oncotarget. 6: 9476-87. PMID 25823815  1
2015 You L, Yan K, Zou J, Zhao H, Bertos NR, Park M, Wang E, Yang XJ. The chromatin regulator Brpf1 regulates embryo development and cell proliferation. The Journal of Biological Chemistry. 290: 11349-64. PMID 25773539 DOI: 10.1074/jbc.M115.643189  1
2015 You L, Yan K, Zhou J, Zhao H, Bertos NR, Park M, Wang E, Yang XJ. The lysine acetyltransferase activator Brpf1 governs dentate gyrus development through neural stem cells and progenitors. Plos Genetics. 11: e1005034. PMID 25757017 DOI: 10.1371/journal.pgen.1005034  1
2015 Ioannou MS, Bell ES, Girard M, Chaineau M, Hamlin JN, Daubaras M, Monast A, Park M, Hodgson L, McPherson PS. DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior. The Journal of Cell Biology. 208: 629-48. PMID 25713415 DOI: 10.1083/jcb.201407068  1
2015 You L, Zou J, Zhao H, Bertos NR, Park M, Wang E, Yang XJ. Deficiency of the chromatin regulator BRPF1 causes abnormal brain development. The Journal of Biological Chemistry. 290: 7114-29. PMID 25568313 DOI: 10.1074/jbc.M114.635250  1
2015 Havrylov S, Park M. MS/MS-based strategies for proteomic profiling of invasive cell structures. Proteomics. 15: 272-86. PMID 25303514 DOI: 10.1002/pmic.201400220  1
2014 Guo J, Canaff L, Rajadurai CV, Fils-Aimé N, Tian J, Dai M, Korah J, Villatoro M, Park M, Ali S, Lebrun JJ. Breast cancer anti-estrogen resistance 3 inhibits transforming growth factor β/Smad signaling and associates with favorable breast cancer disease outcomes. Breast Cancer Research : Bcr. 16: 476. PMID 25499443 DOI: 10.1186/s13058-014-0476-9  1
2014 Tofigh A, Suderman M, Paquet ER, Livingstone J, Bertos N, Saleh SM, Zhao H, Souleimanova M, Cory S, Lesurf R, Shahalizadeh S, Garcia Lopez N, Riazalhosseini Y, Omeroglu A, Ursini-Siegel J, ... Park M, et al. The prognostic ease and difficulty of invasive breast carcinoma. Cell Reports. 9: 129-42. PMID 25284793 DOI: 10.1016/j.celrep.2014.08.073  1
2014 Hudson J, Ha JR, Sabourin V, Ahn R, La Selva R, Livingstone J, Podmore L, Knight J, Forrest L, Beauchemin N, Hallett M, Park M, Ursini-Siegel J. p66ShcA promotes breast cancer plasticity by inducing an epithelial-to-mesenchymal transition. Molecular and Cellular Biology. 34: 3689-701. PMID 25071152 DOI: 10.1128/MCB.00341-14  1
2014 Lai AZ, Cory S, Zhao H, Gigoux M, Monast A, Guiot MC, Huang S, Tofigh A, Thompson C, Naujokas M, Marcus VA, Bertos N, Sehat B, Perera RM, Bell ES, ... ... Park M, et al. Dynamic reprogramming of signaling upon met inhibition reveals a mechanism of drug resistance in gastric cancer. Science Signaling. 7: ra38. PMID 24757178 DOI: 10.1126/scisignal.2004839  1
2013 Wallace JA, Li F, Balakrishnan S, Cantemir-Stone CZ, Pecot T, Martin C, Kladney RD, Sharma SM, Trimboli AJ, Fernandez SA, Yu L, Rosol TJ, Stromberg PC, Lesurf R, Hallett M, ... Park M, et al. Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer. Plos One. 8: e71533. PMID 23977064 DOI: 10.1371/journal.pone.0071533  1
2013 Ahn R, Sabourin V, Ha JR, Cory S, Maric G, Im YK, Hardy WR, Zhao H, Park M, Hallett M, Siegel PM, Pawson T, Ursini-Siegel J. The ShcA PTB domain functions as a biological sensor of phosphotyrosine signaling during breast cancer progression. Cancer Research. 73: 4521-32. PMID 23695548 DOI: 10.1158/0008-5472.CAN-12-4178  1
2013 Laurin M, Huber J, Pelletier A, Houalla T, Park M, Fukui Y, Haibe-Kains B, Muller WJ, Côté JF. Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proceedings of the National Academy of Sciences of the United States of America. 110: 7434-9. PMID 23592719 DOI: 10.1073/pnas.1213050110  1
2013 Ursini-Siegel J, Park M. It takes two to tango in the microenvironment! Breast Cancer Research : Bcr. 15: 102. PMID 23510134 DOI: 10.1186/bcr3388  1
2013 Knight JF, Lesurf R, Zhao H, Pinnaduwage D, Davis RR, Saleh SM, Zuo D, Naujokas MA, Chughtai N, Herschkowitz JI, Prat A, Mulligan AM, Muller WJ, Cardiff RD, Gregg JP, ... ... Park M, et al. Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 110: E1301-10. PMID 23509284 DOI: 10.1073/pnas.1210353110  1
2013 Bertos NR, Park M. Role of stroma in disease progression Experimental and Clinical Metastasis: a Comprehensive Review. 2147483647: 129-147. DOI: 10.1007/978-1-4614-3685-0_10  1
2012 Bell ES, Park M. Models of crk adaptor proteins in cancer. Genes & Cancer. 3: 341-52. PMID 23226572 DOI: 10.1177/1947601912459951  1
2012 Mourskaia AA, Amir E, Dong Z, Tiedemann K, Cory S, Omeroglu A, Bertos N, Ouellet V, Clemons M, Scheffer GL, Park M, Hallett M, Komarova SV, Siegel PM. ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone. Breast Cancer Research : Bcr. 14: R149. PMID 23174366 DOI: 10.1186/bcr3361  1
2012 Pepin F, Bertos N, Laferrière J, Sadekova S, Souleimanova M, Zhao H, Finak G, Meterissian S, Hallett MT, Park M. Gene-expression profiling of microdissected breast cancer microvasculature identifies distinct tumor vascular subtypes. Breast Cancer Research : Bcr. 14: R120. PMID 22906178 DOI: 10.1186/bcr3246  1
2012 Lu KV, Chang JP, Parachoniak CA, Pandika MM, Aghi MK, Meyronet D, Isachenko N, Fouse SD, Phillips JJ, Cheresh DA, Park M, Bergers G. VEGF inhibits tumor cell invasion and mesenchymal transition through a MET/VEGFR2 complex. Cancer Cell. 22: 21-35. PMID 22789536 DOI: 10.1016/j.ccr.2012.05.037  1
2012 Fathers KE, Bell ES, Rajadurai CV, Cory S, Zhao H, Mourskaia A, Zuo D, Madore J, Monast A, Mes-Masson AM, Grosset AA, Gaboury L, Hallet M, Siegel P, Park M. Crk adaptor proteins act as key signaling integrators for breast tumorigenesis. Breast Cancer Research : Bcr. 14: R74. PMID 22569336 DOI: 10.1186/bcr3183  1
2012 Garbe JC, Pepin F, Pelissier FA, Sputova K, Fridriksdottir AJ, Guo DE, Villadsen R, Park M, Petersen OW, Borowsky AD, Stampfer MR, Labarge MA. Accumulation of multipotent progenitors with a basal differentiation bias during aging of human mammary epithelia. Cancer Research. 72: 3687-701. PMID 22552289 DOI: 10.1158/0008-5472.CAN-12-0157  1
2012 Wang Y, Roche O, Xu C, Moriyama EH, Heir P, Chung J, Roos FC, Chen Y, Finak G, Milosevic M, Wilson BC, Teh BT, Park M, Irwin MS, Ohh M. Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1. Proceedings of the National Academy of Sciences of the United States of America. 109: 4892-7. PMID 22411794 DOI: 10.1073/pnas.1112129109  1
2012 Parachoniak CA, Park M. Dynamics of receptor trafficking in tumorigenicity. Trends in Cell Biology. 22: 231-40. PMID 22397948 DOI: 10.1016/j.tcb.2012.02.002  1
2012 Rajadurai CV, Havrylov S, Zaoui K, Vaillancourt R, Stuible M, Naujokas M, Zuo D, Tremblay ML, Park M. Met receptor tyrosine kinase signals through a cortactin-Gab1 scaffold complex, to mediate invadopodia. Journal of Cell Science. 125: 2940-53. PMID 22366451 DOI: 10.1242/jcs.100834  1
2012 Lai AZ, Durrant M, Zuo D, Ratcliffe CD, Park M. Met kinase-dependent loss of the E3 ligase Cbl in gastric cancer. The Journal of Biological Chemistry. 287: 8048-59. PMID 22262855 DOI: 10.1074/jbc.M112.339820  1
2012 Bronisz A, Godlewski J, Wallace JA, Merchant AS, Nowicki MO, Mathsyaraja H, Srinivasan R, Trimboli AJ, Martin CK, Li F, Yu L, Fernandez SA, Pécot T, Rosol TJ, Cory S, ... ... Park M, et al. Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nature Cell Biology. 14: 159-67. PMID 22179046 DOI: 10.1038/ncb2396  1
2012 Pla-Roca M, Leulmi RF, Tourekhanova S, Bergeron S, Laforte V, Moreau E, Gosline SJ, Bertos N, Hallett M, Park M, Juncker D. Antibody colocalization microarray: a scalable technology for multiplex protein analysis in complex samples. Molecular & Cellular Proteomics : McP. 11: M111.011460. PMID 22171321 DOI: 10.1074/mcp.M111.011460  1
2012 Cheng B, Ling C, Dai Y, Lu Y, Glushakova LG, Gee SW, McGoogan KE, Aslanidi GV, Park M, Stacpoole PW, Siemann D, Liu C, Srivastava A, Ling C. Development of optimized AAV3 serotype vectors: mechanism of high-efficiency transduction of human liver cancer cells. Gene Therapy. 19: 375-84. PMID 21776025 DOI: 10.1038/gt.2011.105  1
2011 Sangwan V, Abella J, Lai A, Bertos N, Stuible M, Tremblay ML, Park M. Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors. The Journal of Biological Chemistry. 286: 45000-13. PMID 22045810 DOI: 10.1074/jbc.M111.270934  1
2011 Bertos NR, Park M. Breast cancer - one term, many entities? The Journal of Clinical Investigation. 121: 3789-96. PMID 21965335 DOI: 10.1172/JCI57100  1
2011 Parachoniak CA, Luo Y, Abella JV, Keen JH, Park M. GGA3 functions as a switch to promote Met receptor recycling, essential for sustained ERK and cell migration. Developmental Cell. 20: 751-63. PMID 21664574 DOI: 10.1016/j.devcel.2011.05.007  1
2011 Liu X, Nugoli M, Laferrière J, Saleh SM, Rodrigue-Gervais IG, Saleh M, Park M, Hallett MT, Muller WJ, Giguère V. Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 108: 774-9. PMID 21187396 DOI: 10.1073/pnas.1011845108  1
2011 Tabariès S, Dong Z, Annis MG, Omeroglu A, Pepin F, Ouellet V, Russo C, Hassanain M, Metrakos P, Diaz Z, Basik M, Bertos N, Park M, Guettier C, Adam R, et al. Claudin-2 is selectively enriched in and promotes the formation of breast cancer liver metastases through engagement of integrin complexes. Oncogene. 30: 1318-28. PMID 21076473 DOI: 10.1038/onc.2010.518  1
2011 Bertos NR, Sangwan V, Yang XJ, Park M. Covalent protein modification as a mechanism for dynamic recruitment of specific interactors Protein Reviews. 13: 259-279. DOI: 10.1007/978-1-4419-6382-6-11  1
2010 Myhre S, Mohammed H, Tramm T, Alsner J, Finak G, Park M, Overgaard J, Børresen-Dale AL, Frigessi A, Sørlie T. In silico ascription of gene expression differences to tumor and stromal cells in a model to study impact on breast cancer outcome. Plos One. 5: e14002. PMID 21124964 DOI: 10.1371/journal.pone.0014002  1
2010 Ursini-Siegel J, Cory S, Zuo D, Hardy WR, Rexhepaj E, Lam S, Schade B, Jirstrom K, Bjur E, Piccirillo CA, Denardo D, Coussens LM, Brennan DJ, Gallagher WM, Park M, et al. Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response. Cancer Research. 70: 7776-87. PMID 20924104 DOI: 10.1158/0008-5472.CAN-10-2229  1
2010 Eichner LJ, Perry MC, Dufour CR, Bertos N, Park M, St-Pierre J, Giguère V. miR-378(∗) mediates metabolic shift in breast cancer cells via the PGC-1β/ERRγ transcriptional pathway. Cell Metabolism. 12: 352-61. PMID 20889127 DOI: 10.1016/j.cmet.2010.09.002  1
2010 Hardy S, Wong NN, Muller WJ, Park M, Tremblay ML. Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. Cancer Research. 70: 8959-67. PMID 20841483 DOI: 10.1158/0008-5472.CAN-10-2041  1
2010 Rose AA, Annis MG, Dong Z, Pepin F, Hallett M, Park M, Siegel PM. ADAM10 releases a soluble form of the GPNMB/Osteoactivin extracellular domain with angiogenic properties. Plos One. 5: e12093. PMID 20711474 DOI: 10.1371/journal.pone.0012093  1
2010 Abella JV, Parachoniak CA, Sangwan V, Park M. Dorsal ruffle microdomains potentiate Met receptor tyrosine kinase signaling and down-regulation. The Journal of Biological Chemistry. 285: 24956-67. PMID 20529867 DOI: 10.1074/jbc.M110.127985  1
2010 Stuible M, Abella JV, Feldhammer M, Nossov M, Sangwan V, Blagoev B, Park M, Tremblay ML. PTP1B targets the endosomal sorting machinery: dephosphorylation of regulatory sites on the endosomal sorting complex required for transport component STAM2. The Journal of Biological Chemistry. 285: 23899-907. PMID 20504764 DOI: 10.1074/jbc.M110.115295  1
2010 Abella JV, Vaillancourt R, Frigault MM, Ponzo MG, Zuo D, Sangwan V, Larose L, Park M. The Gab1 scaffold regulates RTK-dependent dorsal ruffle formation through the adaptor Nck. Journal of Cell Science. 123: 1306-19. PMID 20332103 DOI: 10.1242/jcs.062570  1
2010 Ponzo MG, Park M. The Met receptor tyrosine kinase and basal breast cancer. Cell Cycle (Georgetown, Tex.). 9: 1043-50. PMID 20237428  1
2010 Rose AA, Grosset AA, Dong Z, Russo C, Macdonald PA, Bertos NR, St-Pierre Y, Simantov R, Hallett M, Park M, Gaboury L, Siegel PM. Glycoprotein nonmetastatic B is an independent prognostic indicator of recurrence and a novel therapeutic target in breast cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 2147-56. PMID 20215530 DOI: 10.1158/1078-0432.CCR-09-1611  1
2010 Fathers KE, Rodrigues S, Zuo D, Murthy IV, Hallett M, Cardiff R, Park M. CrkII transgene induces atypical mammary gland development and tumorigenesis. The American Journal of Pathology. 176: 446-60. PMID 20008144 DOI: 10.2353/ajpath.2010.090383  1
2009 Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N, Thompson JC, Caserta E, Wang H, Chong JL, Naidu S, Wei G, Sharma SM, Stephens JA, Fernandez SA, ... ... Park M, et al. Pten in stromal fibroblasts suppresses mammary epithelial tumours. Nature. 461: 1084-91. PMID 19847259 DOI: 10.1038/nature08486  1
2009 Lai AZ, Abella JV, Park M. Crosstalk in Met receptor oncogenesis. Trends in Cell Biology. 19: 542-51. PMID 19758803 DOI: 10.1016/j.tcb.2009.07.002  1
2009 Kedinger V, Sansregret L, Harada R, Vadnais C, Cadieux C, Fathers K, Park M, Nepveu A. p110 CUX1 homeodomain protein stimulates cell migration and invasion in part through a regulatory cascade culminating in the repression of E-cadherin and occludin. The Journal of Biological Chemistry. 284: 27701-11. PMID 19635798 DOI: 10.1074/jbc.M109.031849  1
2009 Deblois G, Hall JA, Perry MC, Laganière J, Ghahremani M, Park M, Hallett M, Giguère V. Genome-wide identification of direct target genes implicates estrogen-related receptor alpha as a determinant of breast cancer heterogeneity. Cancer Research. 69: 6149-57. PMID 19622763 DOI: 10.1158/0008-5472.CAN-09-1251  1
2009 Ponzo MG, Lesurf R, Petkiewicz S, O'Malley FP, Pinnaduwage D, Andrulis IL, Bull SB, Chughtai N, Zuo D, Souleimanova M, Germain D, Omeroglu A, Cardiff RD, Hallett M, Park M. Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer. Proceedings of the National Academy of Sciences of the United States of America. 106: 12903-8. PMID 19617568 DOI: 10.1073/pnas.0810402106  1
2009 Finak G, Laferrière J, Hallett M, Park M. [The tumor microenvironment: a new tool to predict breast cancer outcome]. MéDecine Sciences : M/S. 25: 439-41. PMID 19480818 DOI: 10.1051/medsci/2009255439  1
2009 Paliouras GN, Naujokas MA, Park M. Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor. Molecular and Cellular Biology. 29: 3018-32. PMID 19289496 DOI: 10.1128/MCB.01286-08  1
2009 Wang Y, Roche O, Yan MS, Finak G, Evans AJ, Metcalf JL, Hast BE, Hanna SC, Wondergem B, Furge KA, Irwin MS, Kim WY, Teh BT, Grinstein S, Park M, et al. Regulation of endocytosis via the oxygen-sensing pathway. Nature Medicine. 15: 319-24. PMID 19252501 DOI: 10.1038/nm.1922  1
2009 Abella JV, Park M. Breakdown of endocytosis in the oncogenic activation of receptor tyrosine kinases. American Journal of Physiology. Endocrinology and Metabolism. 296: E973-84. PMID 19240253 DOI: 10.1152/ajpendo.90857.2008  1
2009 Parachoniak CA, Park M. Distinct recruitment of Eps15 via Its coiled-coil domain is required for efficient down-regulation of the met receptor tyrosine kinase. The Journal of Biological Chemistry. 284: 8382-94. PMID 19109251 DOI: 10.1074/jbc.M807607200  1
2009 Finak G, Bertos N, Hallett M, Park M. Stromal signature identifies basal breast cancers Nature Medicine. 15: 238. DOI: 10.1038/nm0309-238a  1
2008 Sangwan V, Paliouras GN, Abella JV, Dubé N, Monast A, Tremblay ML, Park M. Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase. The Journal of Biological Chemistry. 283: 34374-83. PMID 18819921 DOI: 10.1074/jbc.M805916200  1
2008 Finak G, Bertos N, Pepin F, Sadekova S, Souleimanova M, Zhao H, Chen H, Omeroglu G, Meterissian S, Omeroglu A, Hallett M, Park M. Stromal gene expression predicts clinical outcome in breast cancer. Nature Medicine. 14: 518-27. PMID 18438415 DOI: 10.1038/nm1764  1
2008 Frigault MM, Naujokas MA, Park M. Gab2 requires membrane targeting and the Met binding motif to promote lamellipodia, cell scatter, and epithelial morphogenesis downstream from the Met receptor. Journal of Cellular Physiology. 214: 694-705. PMID 17894413 DOI: 10.1002/jcp.21264  1
2008 Finak G, Hallett M, Park M, Pepin F. Bioinformatics Tools for Gene-expression Studies Handbook of Genome Research: Genomics, Proteomics, Metabolomics, Bioinformatics, Ethical and Legal Issues. 415-432. DOI: 10.1002/9783527619733.ch17  1
2007 Kozlov G, Nguyen L, Lin T, De Crescenzo G, Park M, Gehring K. Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD. The Journal of Biological Chemistry. 282: 35787-95. PMID 17897937 DOI: 10.1074/jbc.M705655200  1
2007 Peschard P, Kozlov G, Lin T, Mirza IA, Berghuis AM, Lipkowitz S, Park M, Gehring K. Structural basis for ubiquitin-mediated dimerization and activation of the ubiquitin protein ligase Cbl-b. Molecular Cell. 27: 474-85. PMID 17679095 DOI: 10.1016/j.molcel.2007.06.023  1
2007 Kozlov G, Peschard P, Zimmerman B, Lin T, Moldoveanu T, Mansur-Azzam N, Gehring K, Park M. Structural basis for UBA-mediated dimerization of c-Cbl ubiquitin ligase. The Journal of Biological Chemistry. 282: 27547-55. PMID 17635922 DOI: 10.1074/jbc.M703333200  1
2007 Mak HHL, Peschard P, Lin T, Naujokas MA, Zuo D, Park M. Oncogenic activation of the Met receptor tyrosine kinase fusion protein, Tpr-Met, involves exclusion from the endocytic degradative pathway Oncogene. 26: 7213-7221. PMID 17533376 DOI: 10.1038/sj.onc.1210522  1
2007 Peschard P, Park M. From Tpr-Met to Met, tumorigenesis and tubes Oncogene. 26: 1276-1285. PMID 17322912 DOI: 10.1038/sj.onc.1210201  1
2006 Finak G, Sadekova S, Pepin F, Hallett M, Meterissian S, Halwani F, Khetani K, Souleimanova M, Zabolotny B, Omeroglu A, Park M. Gene expression signatures of morphologically normal breast tissue identify basal-like tumors. Breast Cancer Research : Bcr. 8: R58. PMID 17054791 DOI: 10.1186/bcr1608  1
2006 Mood K, Saucier C, Bong YS, Lee HS, Park M, Daar IO. Gab1 is required for cell cycle transition, cell proliferation, and transformation induced by an oncogenic met receptor. Molecular Biology of the Cell. 17: 3717-28. PMID 16775003 DOI: 10.1091/mbc.E06-03-0244  1
2006 Mood K, Saucier C, Ishimura A, Bong YS, Lee HS, Park M, Daar IO. Oncogenic Met receptor induces cell-cycle progression in Xenopus oocytes independent of direct Grb2 and Shc binding or Mos synthesis, but requires phosphatidylinositol 3-kinase and Raf signaling. Journal of Cellular Physiology. 207: 271-85. PMID 16331688 DOI: 10.1002/jcp.20564  1
2006 Sangwan V, Paliouras GN, Cheng A, Dubé N, Tremblay ML, Park M. Protein-tyrosine phosphatase 1B deficiency protects against Fas-induced hepatic failure. The Journal of Biological Chemistry. 281: 221-8. PMID 16234234 DOI: 10.1074/jbc.M507858200  1
2006 Sangwan V, Park M. Receptor tyrosine kinases: Role in cancer progression Current Oncology. 13: 191-193.  1
2005 Suzuki M, Mimuro H, Suzuki T, Park M, Yamamoto T, Sasakawa C. Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. The Journal of Experimental Medicine. 202: 1235-47. PMID 16275761 DOI: 10.1084/jem.20051027  1
2005 Abella JV, Peschard P, Naujokas MA, Lin T, Saucier C, Urbé S, Park M. Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Molecular and Cellular Biology. 25: 9632-45. PMID 16227611 DOI: 10.1128/MCB.25.21.9632-9645.2005  1
2005 Kim H, Chan R, Dankort DL, Zuo D, Najoukas M, Park M, Muller WJ. The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation. Oncogene. 24: 7599-607. PMID 16170374 DOI: 10.1038/sj.onc.1208898  1
2005 Long J, Zuo D, Park M. Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. The Journal of Biological Chemistry. 280: 35477-89. PMID 16061479 DOI: 10.1074/jbc.M504477200  1
2005 Rodrigues SP, Fathers KE, Chan G, Zuo D, Halwani F, Meterissian S, Park M. CrkI and CrkII function as key signaling integrators for migration and invasion of cancer cells. Molecular Cancer Research : McR. 3: 183-94. PMID 15831672 DOI: 10.1158/1541-7786.MCR-04-0211  1
2005 Khoury H, Naujokas MA, Zuo D, Sangwan V, Frigault MM, Petkiewicz S, Dankort DL, Muller WJ, Park M. HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion. Molecular Biology of the Cell. 16: 550-61. PMID 15548598 DOI: 10.1091/mbc.E04-07-0567  1
2004 Kozlov G, Perreault A, Schrag JD, Park M, Cygler M, Gehring K, Ekiel I. Insights into function of PSI domains from structure of the Met receptor PSI domain. Biochemical and Biophysical Research Communications. 321: 234-40. PMID 15358240 DOI: 10.1016/j.bbrc.2004.06.132  1
2004 Peschard P, Ishiyama N, Lin T, Lipkowitz S, Park M. A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation. The Journal of Biological Chemistry. 279: 29565-71. PMID 15123609 DOI: 10.1074/jbc.M403954200  1
2004 Saucier C, Khoury H, Lai KM, Peschard P, Dankort D, Naujokas MA, Holash J, Yancopoulos GD, Muller WJ, Pawson T, Park M. The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 101: 2345-50. PMID 14983012 DOI: 10.1073/pnas.0308065101  1
2003 Lamorte L, Park M. ARF1 and ARF6 are dispensable for Crk-dependent epithelial-mesenchymal-like transitions. Anticancer Research. 23: 2085-92. PMID 12894582  1
2003 Lamorte L, Rodrigues S, Sangwan V, Turner CE, Park M. Crk associates with a multimolecular Paxillin/GIT2/beta-PIX complex and promotes Rac-dependent relocalization of Paxillin to focal contacts. Molecular Biology of the Cell. 14: 2818-31. PMID 12857867 DOI: 10.1091/mbc.E02-08-0497  1
2003 Peschard P, Park M. Escape from Cbl-mediated downregulation: a recurrent theme for oncogenic deregulation of receptor tyrosine kinases. Cancer Cell. 3: 519-23. PMID 12842080 DOI: 10.1016/S1535-6108(03)00136-3  1
2003 Lock LS, Frigault MM, Saucier C, Park M. Grb2-independent recruitment of Gab1 requires the C-terminal lobe and structural integrity of the Met receptor kinase domain. The Journal of Biological Chemistry. 278: 30083-90. PMID 12766170 DOI: 10.1074/jbc.M302675200  1
2003 Maroun CR, Naujokas MA, Park M. Membrane targeting of Grb2-associated binder-1 (Gab1) scaffolding protein through Src myristoylation sequence substitutes for Gab1 pleckstrin homology domain and switches an epidermal growth factor response to an invasive morphogenic program. Molecular Biology of the Cell. 14: 1691-708. PMID 12686619 DOI: 10.1091/mbc.E02-06-0352  1
2003 Palka HL, Park M, Tonks NK. Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1. The Journal of Biological Chemistry. 278: 5728-35. PMID 12475979 DOI: 10.1074/jbc.M210656200  1
2002 Lamorte L, Rodrigues S, Naujokas M, Park M. Crk synergizes with epidermal growth factor for epithelial invasion and morphogenesis and is required for the met morphogenic program. The Journal of Biological Chemistry. 277: 37904-11. PMID 12138161 DOI: 10.1074/jbc.M201743200  1
2002 Lock LS, Maroun CR, Naujokas MA, Park M. Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis. Molecular Biology of the Cell. 13: 2132-46. PMID 12058075 DOI: 10.1091/mbc.02-02-0031.  1
2002 Lamorte L, Royal I, Naujokas M, Park M. Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions. Molecular Biology of the Cell. 13: 1449-61. PMID 12006644 DOI: 10.1091/mbc.01-10-0477  1
2002 Saucier C, Papavasiliou V, Palazzo A, Naujokas MA, Kremer R, Park M. Use of signal specific receptor tyrosine kinase oncoproteins reveals that pathways downstream from Grb2 or Shc are sufficient for cell transformation and metastasis. Oncogene. 21: 1800-11. PMID 11896612 DOI: 10.1038/sj.onc.1205261  1
2001 Peschard P, Fournier TM, Lamorte L, Naujokas MA, Band H, Langdon WY, Park M. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Molecular Cell. 8: 995-1004. PMID 11741535 DOI: 10.1016/S1097-2765(01)00378-1  1
2001 Lamorte L, Park M. The receptor tyrosine kinases: role in cancer progression. Surgical Oncology Clinics of North America. 10: 271-88, viii. PMID 11382587  1
2001 Khoury H, Dankort DL, Sadekova S, Naujokas MA, Muller WJ, Park M. Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor. Oncogene. 20: 788-99. PMID 11314013 DOI: 10.1038/sj.onc.1204166  1
2000 Lamorte L, Kamikura DM, Park M. A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein. Oncogene. 19: 5973-81. PMID 11146548 DOI: 10.1038/sj.onc.1203977  0.88
2000 Fournier TM, Lamorte L, Maroun CR, Lupher M, Band H, Langdon W, Park M. Cbl-transforming variants trigger a cascade of molecular alterations that lead to epithelial mesenchymal conversion. Molecular Biology of the Cell. 11: 3397-410. PMID 11029044  1
2000 Lock LS, Royal I, Naujokas MA, Park M. Identification of an atypical Grb2 carboxyl-terminal SH3 domain binding site in Gab docking proteins reveals Grb2-dependent and -independent recruitment of Gab1 to receptor tyrosine kinases. The Journal of Biological Chemistry. 275: 31536-45. PMID 10913131 DOI: 10.1074/jbc.M003597200  1
2000 Royal I, Lamarche-Vane N, Lamorte L, Kaibuchi K, Park M. Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation. Molecular Biology of the Cell. 11: 1709-25. PMID 10793146  1
2000 Kamikura DM, Khoury H, Maroun C, Naujokas MA, Park M. Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44. Molecular and Cellular Biology. 20: 3482-96. PMID 10779338 DOI: 10.1128/MCB.20.10.3482-3496.2000  1
1999 Maroun CR, Holgado-Madruga M, Royal I, Naujokas MA, Fournier TM, Wong AJ, Park M. The Gab1 PH domain is required for localization of Gab1 at sites of cell-cell contact and epithelial morphogenesis downstream from the met receptor tyrosine kinase. Molecular and Cellular Biology. 19: 1784-99. PMID 10022866  1
1997 Royal I, Fournier TM, Park M. Differential requirement of Grb2 and PI3-kinase in HGF/SF-induced cell motility and tubulogenesis. Journal of Cellular Physiology. 173: 196-201. PMID 9365521 DOI: 10.1002/(SICI)1097-4652(199711)173:2<196::AID-JCP20>3.0.CO;2-D  1
1997 Nguyen L, Holgado-Madruga M, Maroun C, Fixman ED, Kamikura D, Fournier T, Charest A, Tremblay ML, Wong AJ, Park M. Association of the multisubstrate docking protein Gab1 with the hepatocyte growth factor receptor requires a functional Grb2 binding site involving tyrosine 1356 Journal of Biological Chemistry. 272: 20811-20819. PMID 9252406 DOI: 10.1074/jbc.272.33.20811  1
1997 Fixman ED, Holgado-Madruga M, Nguyen L, Kamikura DM, Fournier TM, Wong AJ, Park M. Efficient cellular transformation by the Met oncoprotein requires a functional Grb2 binding site and correlates with phosphorylation of the Grb2-associated proteins, Cbl and Gab1. The Journal of Biological Chemistry. 272: 20167-72. PMID 9242692 DOI: 10.1074/jbc.272.32.20167  1
1997 Jin L, Fuchs A, Schnitt SJ, Yao Y, Joseph A, Lamszus K, Park M, Goldberg ID, Rosen EM. Expression of scatter factor and c-met receptor in benign and malignant breast tissue Cancer. 79: 749-760. PMID 9024713 DOI: 10.1002/(SICI)1097-0142(19970215)79:4<749::AID-CNCR12>3.0.CO;2-#  1
1996 Fournier TM, Kamikura D, Teng K, Park M. Branching tubulogenesis but not scatter of madin-darby canine kidney cells requires a functional Grb2 binding site in the Met receptor tyrosine kinase. The Journal of Biological Chemistry. 271: 22211-7. PMID 8703035 DOI: 10.1074/jbc.271.36.22211  1
1996 Fixman ED, Fournier TM, Kamikura DM, Naujokas MA, Park M. Pathways downstream of Shc and Grb2 are required for cell transformation by the tpr-Met oncoprotein. The Journal of Biological Chemistry. 271: 13116-22. PMID 8662733 DOI: 10.1074/jbc.271.22.13116  1
1995 Royal I, Park M. Hepatocyte growth factor-induced scatter of Madin-Darby canine kidney cells requires phosphatidylinositol 3-kinase. The Journal of Biological Chemistry. 270: 27780-7. PMID 7499247 DOI: 10.1074/jbc.270.46.27780  1
1985 Dean M, Park M, Le Beau MM, Robins TS, Diaz MO, Rowley JD, Blair DG, Vande Woude GF. The human met oncogene is related to the tyrosine kinase oncogenes Nature. 318: 385-388. PMID 4069211 DOI: 10.1038/318385a0  1
1984 Cooper CS, Park M, Blair DG, Tainsky MA, Huebner K, Croce CM, Vande Woude GF. Molecular cloning of a new transforming gene from a chemically transformed human cell line Nature. 311: 29-33. PMID 6590967 DOI: 10.1038/311029a0  1
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