Timothy J. Mitchison - Publications

Affiliations: 
Systems Biology Harvard Medical School, Boston, MA, United States 
Area:
Microtubules, Actin, Mitosis, Cell cycle
Website:
http://www.hms.harvard.edu/dms/bbs/fac/Mitchison.php

260 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Mitchison TJ, Field CM. Toward synthetic cells. Science (New York, N.Y.). 366: 569-570. PMID 31672880 DOI: 10.1126/science.aaz5635  1
2019 Field CM, Pelletier JF, Mitchison TJ. Disassembly of Actin and Keratin Networks by Aurora B Kinase at the Midplane of Cleaving Xenopus laevis Eggs. Current Biology : Cb. PMID 31178324 DOI: 10.1016/j.cub.2019.05.016  1
2019 Florian S, Iwamoto Y, Coughlin M, Weissleder R, Mitchison TJ. A human organoid system that self-organizes to recapitulate growth and differentiation of a benign mammary tumor. Proceedings of the National Academy of Sciences of the United States of America. PMID 31101720 DOI: 10.1073/pnas.1702372116  0.84
2019 Gasic I, Boswell SA, Mitchison TJ. Tubulin mRNA stability is sensitive to change in microtubule dynamics caused by multiple physiological and toxic cues. Plos Biology. 17: e3000225. PMID 30964857 DOI: 10.1371/journal.pbio.3000225  1
2019 Silva MC, Ferguson FM, Cai Q, Donovan KA, Nandi G, Patnaik D, Zhang T, Huang HT, Lucente DE, Dickerson BC, Mitchison TJ, Fischer ES, Gray NS, Haggarty SJ. Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models. Elife. 8. PMID 30907729 DOI: 10.7554/eLife.45457  0.8
2019 Nguyen T, Mitchison TJ, Wühr M. Immunofluorescence of Microtubule Assemblies in Amphibian Oocytes and Early Embryos. Methods in Molecular Biology (Clifton, N.J.). 1920: 17-32. PMID 30737683 DOI: 10.1007/978-1-4939-9009-2_2  1
2018 Gasic I, Mitchison TJ. Autoregulation and repair in microtubule homeostasis. Current Opinion in Cell Biology. 56: 80-87. PMID 30415186 DOI: 10.1016/j.ceb.2018.10.003  1
2018 Jun HJ, Appleman VA, Wu HJ, Rose CM, Pineda JJ, Yeo AT, Delcuze B, Lee C, Gyuris A, Zhu H, Woolfenden S, Bronisz A, Nakano I, Chiocca EA, Bronson RT, ... ... Mitchison TJ, et al. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nature Communications. 9: 3116. PMID 30082792 DOI: 10.1038/s41467-018-05036-4  0.88
2018 Wang Y, Li YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, ... ... Mitchison TJ, et al. Correction: MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Elife. 7. PMID 29528283 DOI: 10.7554/eLife.36414  0.6
2018 Field CM, Mitchison TJ. Assembly of Spindles and Asters in Xenopus Egg Extracts. Cold Spring Harbor Protocols. PMID 29437996 DOI: 10.1101/pdb.prot099796  1
2017 Mitchison TJ, Field CM. Spindle-to-Cortex Communication in Cleaving Frog Eggs. Cold Spring Harbor Symposia On Quantitative Biology. PMID 29196560 DOI: 10.1101/sqb.2017.82.033654  1
2017 Zhang L, Hou Y, Li Z, Ji X, Wang Z, Wang H, Tian X, Yu F, Yang Z, Pi L, Mitchison TJ, Lu Q, Zhang X. Correction: 27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells. Elife. 6. PMID 28470149 DOI: 10.7554/eLife.28212  0.56
2017 Guild J, Ginzberg MB, Hueschen CL, Mitchison TJ, Dumont S. Increased lateral microtubule contact at the cell cortex is sufficient to drive mammalian spindle elongation. Molecular Biology of the Cell. PMID 28468979 DOI: 10.1091/mbc.E17-03-0171  0.84
2017 Hanley ML, Yoo TY, Sonnett M, Needleman DJ, Mitchison TJ. Chromosomal passenger complex hydrodynamics suggests chaperoning of the inactive state by nucleoplasmin/nucleophosmin. Molecular Biology of the Cell. PMID 28404751 DOI: 10.1091/mbc.E16-12-0860  0.84
2017 Shi J, Mitchison TJ. Cell death response to anti-mitotic drug treatment in cell culture, mouse tumor model and the clinic. Endocrine-Related Cancer. PMID 28249963 DOI: 10.1530/ERC-17-0003  0.68
2017 Zhang L, Hou Y, Li Z, Ji X, Wang Z, Wang H, Tian X, Yu F, Yang Z, Pi L, Mitchison TJ, Lu Q, Zhang X. 27 T ultra-high static magnetic field changes orientation and morphology of mitotic spindles in human cells. Elife. 6. PMID 28244368 DOI: 10.7554/eLife.22911  0.56
2016 Ishihara K, Korolev KS, Mitchison TJ. Physical basis of large microtubule aster growth. Elife. 5. PMID 27892852 DOI: 10.7554/eLife.19145  0.76
2016 Boke E, Mitchison TJ. The Balbiani Body and the Concept of Physiological Amyloids. Cell Cycle (Georgetown, Tex.). 0. PMID 27736303 DOI: 10.1080/15384101.2016.1241605  0.4
2016 Giedt RJ, Fumene Feruglio P, Pathania D, Yang KS, Kilcoyne A, Vinegoni C, Mitchison TJ, Weissleder R. Computational imaging reveals mitochondrial morphology as a biomarker of cancer phenotype and drug response. Scientific Reports. 6: 32985. PMID 27609668 DOI: 10.1038/srep32985  0.32
2016 Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ. Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 27528663 DOI: 10.1073/pnas.1606862113  0.32
2016 Boke E, Ruer M, Wühr M, Coughlin M, Lemaitre R, Gygi SP, Alberti S, Drechsel D, Hyman AA, Mitchison TJ. Amyloid-like Self-Assembly of a Cellular Compartment. Cell. 166: 637-650. PMID 27471966 DOI: 10.1016/j.cell.2016.06.051  1
2016 Groen AC, Mitchison TJ. Purification and Fluorescent Labeling of Tubulin from Xenopus laevis Egg Extracts. Methods in Molecular Biology (Clifton, N.J.). 1413: 35-45. PMID 27193841 DOI: 10.1007/978-1-4939-3542-0_3  0.96
2016 Al-Obaidi N, Mitchison TJ, Crews CM, Mayer TU. Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells. Acs Chemical Biology. PMID 27121275 DOI: 10.1021/acschembio.6b00203  0.32
2015 Son S, Kang JH, Oh S, Kirschner MW, Mitchison TJ, Manalis S. Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis. The Journal of Cell Biology. 211: 757-63. PMID 26598613 DOI: 10.1083/jcb.201505058  1
2015 Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP. The Nuclear Proteome of a Vertebrate. Current Biology : Cb. 25: 2663-71. PMID 26441354 DOI: 10.1016/j.cub.2015.08.047  0.68
2015 Kuhn H, Sopko R, Coughlin M, Perrimon N, Mitchison T. The Atg1-Tor pathway regulates yolk catabolism in Drosophila embryos. Development (Cambridge, England). PMID 26395483 DOI: 10.1242/dev.125419  1
2015 Field CM, Groen AC, Nguyen PA, Mitchison TJ. Spindle to cortex communication in cleaving, polyspermic Xenopus eggs. Molecular Biology of the Cell. PMID 26310438 DOI: 10.1091/mbc.E15-04-0233  0.68
2015 Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Erratum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nature Chemical Biology. 11: 741. PMID 26284675 DOI: 10.1038/nchembio0915-741c  1
2015 Mitchison TJ, Ishihara K, Nguyen P, Wühr M. Size Scaling of Microtubule Assemblies in Early Xenopus Embryos. Cold Spring Harbor Perspectives in Biology. PMID 26261283 DOI: 10.1101/cshperspect.a019182  1
2015 Nguyen PA, Field CM, Groen AC, Mitchison TJ, Loose M. Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins. Methods in Cell Biology. 128: 223-41. PMID 25997350 DOI: 10.1016/bs.mcb.2015.01.007  1
2015 Chittajallu DR, Florian S, Kohler RH, Iwamoto Y, Orth JD, Weissleder R, Danuser G, Mitchison TJ. In vivo cell-cycle profiling in xenograft tumors by quantitative intravital microscopy. Nature Methods. 12: 577-85. PMID 25867850 DOI: 10.1038/nmeth.3363  1
2015 Krukenberg KA, Kim S, Tan ES, Maliga Z, Mitchison TJ. Extracellular poly(ADP-ribose) is a pro-inflammatory signal for macrophages. Chemistry & Biology. 22: 446-52. PMID 25865309 DOI: 10.1016/j.chembiol.2015.03.007  1
2015 Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Corrigendum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nature Chemical Biology. 11: 235. PMID 25689338 DOI: 10.1038/nchembio0315-235d  1
2015 Özlü N, Qureshi MH, Toyoda Y, Renard BY, Mollaoglu G, Özkan NE, Bulbul S, Poser I, Timm W, Hyman AA, Mitchison TJ, Steen JA. Quantitative comparison of a human cancer cell surface proteome between interphase and mitosis. The Embo Journal. 34: 251-65. PMID 25476450 DOI: 10.15252/embj.201385162  1
2014 Ishihara K, Nguyen PA, Groen AC, Field CM, Mitchison TJ. Microtubule nucleation remote from centrosomes may explain how asters span large cells. Proceedings of the National Academy of Sciences of the United States of America. 111: 17715-22. PMID 25468969 DOI: 10.1073/pnas.1418796111  1
2014 Laughney AM, Kim E, Sprachman MM, Miller MA, Kohler RH, Yang KS, Orth JD, Mitchison TJ, Weissleder R. Single-cell pharmacokinetic imaging reveals a therapeutic strategy to overcome drug resistance to the microtubule inhibitor eribulin. Science Translational Medicine. 6: 261ra152. PMID 25378644 DOI: 10.1126/scitranslmed.3009318  1
2014 Li L, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison TJ. Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nature Chemical Biology. 10: 1043-8. PMID 25344812 DOI: 10.1038/nchembio.1661  1
2014 Nguyen PA, Groen AC, Loose M, Ishihara K, Wühr M, Field CM, Mitchison TJ. Spatial organization of cytokinesis signaling reconstituted in a cell-free system. Science (New York, N.Y.). 346: 244-7. PMID 25301629 DOI: 10.1126/science.1256773  1
2014 Choi PJ, Mitchison TJ. Quantitative analysis of resistance to natural killer attacks reveals stepwise killing kinetics. Integrative Biology : Quantitative Biosciences From Nano to Macro. 6: 1153-61. PMID 25228316 DOI: 10.1039/c4ib00096j  1
2014 Krukenberg KA, Jiang R, Steen JA, Mitchison TJ. Basal activity of a PARP1-NuA4 complex varies dramatically across cancer cell lines. Cell Reports. 8: 1808-18. PMID 25199834 DOI: 10.1016/j.celrep.2014.08.009  0.68
2014 Ishihara K, Nguyen PA, Wühr M, Groen AC, Field CM, Mitchison TJ. Organization of early frog embryos by chemical waves emanating from centrosomes. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 369. PMID 25047608 DOI: 10.1098/rstb.2013.0454  1
2014 Mitchison TJ. The engine of microtubule dynamics comes into focus. Cell. 157: 1008-10. PMID 24855939 DOI: 10.1016/j.cell.2014.05.001  1
2014 Wang Y, Lee YM, Baitsch L, Huang A, Xiang Y, Tong H, Lako A, Von T, Choi C, Lim E, Min J, Li L, Stegmeier F, Schlegel R, Eck MJ, ... ... Mitchison TJ, et al. MELK is an oncogenic kinase essential for mitotic progression in basal-like breast cancer cells. Elife. 3: e01763. PMID 24844244 DOI: 10.7554/eLife.01763  1
2014 Groen AC, Ngyuen PA, Field CM, Ishihara K, Mitchison TJ. Glycogen-supplemented mitotic cytosol for analyzing Xenopus egg microtubule organization. Methods in Enzymology. 540: 417-33. PMID 24630120 DOI: 10.1016/B978-0-12-397924-7.00023-6  1
2014 Field CM, Nguyen PA, Ishihara K, Groen AC, Mitchison TJ. Xenopus egg cytoplasm with intact actin. Methods in Enzymology. 540: 399-415. PMID 24630119 DOI: 10.1016/B978-0-12-397924-7.00022-4  1
2014 Coughlin M, Groen AC, Mitchison TJ. Electron microscopy of microtubule cytoskeleton assembly in vitro. Methods in Molecular Biology (Clifton, N.J.). 1117: 259-71. PMID 24357367 DOI: 10.1007/978-1-62703-776-1_12  1
2014 Loose M, Mitchison TJ. The bacterial cell division proteins FtsA and FtsZ self-organize into dynamic cytoskeletal patterns. Nature Cell Biology. 16: 38-46. PMID 24316672 DOI: 10.1038/ncb2885  1
2013 Prentice-Mott HV, Chang CH, Mahadevan L, Mitchison TJ, Irimia D, Shah JV. Biased migration of confined neutrophil-like cells in asymmetric hydraulic environments. Proceedings of the National Academy of Sciences of the United States of America. 110: 21006-11. PMID 24324148 DOI: 10.1073/pnas.1317441110  1
2013 Wang S, Romano FB, Field CM, Mitchison TJ, Rapoport TA. Multiple mechanisms determine ER network morphology during the cell cycle in Xenopus egg extracts. The Journal of Cell Biology. 203: 801-14. PMID 24297752 DOI: 10.1083/jcb.201308001  1
2013 Mitchison TJ. A question of taste. Molecular Biology of the Cell. 24: 3278-80. PMID 24174461 DOI: 10.1091/mbc.E13-07-0410  1
2013 Zidovska A, Weitz DA, Mitchison TJ. Micron-scale coherence in interphase chromatin dynamics. Proceedings of the National Academy of Sciences of the United States of America. 110: 15555-60. PMID 24019504 DOI: 10.1073/pnas.1220313110  1
2013 Barkauskaite E, Brassington A, Tan ES, Warwicker J, Dunstan MS, Banos B, Lafite P, Ahel M, Mitchison TJ, Ahel I, Leys D. Visualization of poly(ADP-ribose) bound to PARG reveals inherent balance between exo- and endo-glycohydrolase activities. Nature Communications. 4: 2164. PMID 23917065 DOI: 10.1038/ncomms3164  1
2013 Tang Y, Xie T, Florian S, Moerke N, Shamu C, Benes C, Mitchison TJ. Differential determinants of cancer cell insensitivity to antimitotic drugs discriminated by a one-step cell imaging assay. Journal of Biomolecular Screening. 18: 1062-71. PMID 23788527 DOI: 10.1177/1087057113493804  1
2013 Kim S, Li L, Maliga Z, Yin Q, Wu H, Mitchison TJ. Anticancer flavonoids are mouse-selective STING agonists. Acs Chemical Biology. 8: 1396-401. PMID 23683494 DOI: 10.1021/cb400264n  1
2013 Choi PJ, Mitchison TJ. Imaging burst kinetics and spatial coordination during serial killing by single natural killer cells. Proceedings of the National Academy of Sciences of the United States of America. 110: 6488-93. PMID 23576740 DOI: 10.1073/pnas.1221312110  1
2013 Kueh HY, Niethammer P, Mitchison TJ. Maintenance of mitochondrial oxygen homeostasis by cosubstrate compensation. Biophysical Journal. 104: 1338-48. PMID 23528093 DOI: 10.1016/j.bpj.2013.01.030  1
2013 Mitchison TJ, Nguyen P, Coughlin M, Groen AC. Self-organization of stabilized microtubules by both spindle and midzone mechanisms in Xenopus egg cytosol. Molecular Biology of the Cell. 24: 1559-73. PMID 23515222 DOI: 10.1091/mbc.E12-12-0850  1
2013 Thurber GM, Yang KS, Reiner T, Kohler RH, Sorger P, Mitchison T, Weissleder R. Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo. Nature Communications. 4: 1504. PMID 23422672 DOI: 10.1038/ncomms2506  1
2013 Petry S, Groen AC, Ishihara K, Mitchison TJ, Vale RD. Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2. Cell. 152: 768-77. PMID 23415226 DOI: 10.1016/j.cell.2012.12.044  1
2012 Vale RD, DeRisi J, Phillips R, Mullins RD, Waterman C, Mitchison TJ. Graduate education. Interdisciplinary graduate training in teaching labs. Science (New York, N.Y.). 338: 1542-3. PMID 23258877 DOI: 10.1126/science.1216570  1
2012 Maiuri P, Terriac E, Paul-Gilloteaux P, Vignaud T, McNally K, Onuffer J, Thorn K, Nguyen PA, Georgoulia N, Soong D, Jayo A, Beil N, Beneke J, Lim JC, Sim CP, ... ... Mitchison TJ, et al. The first World Cell Race. Current Biology : Cb. 22: R673-5. PMID 22974990 DOI: 10.1016/j.cub.2012.07.052  1
2012 Kim S, Peshkin L, Mitchison TJ. Vascular disrupting agent drug classes differ in effects on the cytoskeleton. Plos One. 7: e40177. PMID 22848372 DOI: 10.1371/journal.pone.0040177  1
2012 Zhang X, Wang W, Bedigian AV, Coughlin ML, Mitchison TJ, Eggert US. Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI. Proceedings of the National Academy of Sciences of the United States of America. 109: 12485-90. PMID 22802617 DOI: 10.1073/pnas.1207821109  1
2012 Mitchison T, Wühr M, Nguyen P, Ishihara K, Groen A, Field CM. Growth, interaction, and positioning of microtubule asters in extremely large vertebrate embryo cells. Cytoskeleton (Hoboken, N.J.). 69: 738-50. PMID 22786885 DOI: 10.1002/cm.21050  1
2012 Tan ES, Krukenberg KA, Mitchison TJ. Large-scale preparation and characterization of poly(ADP-ribose) and defined length polymers. Analytical Biochemistry. 428: 126-36. PMID 22743307 DOI: 10.1016/j.ab.2012.06.015  1
2012 Dumont S, Salmon ED, Mitchison TJ. Deformations within moving kinetochores reveal different sites of active and passive force generation. Science (New York, N.Y.). 337: 355-8. PMID 22722252 DOI: 10.1126/science.1221886  1
2012 Nguyen PA, Ishihara K, Wühr M, Mitchison TJ. Pronuclear migration: no attachment? No union, but a futile cycle! Current Biology : Cb. 22: R409-11. PMID 22625860 DOI: 10.1016/j.cub.2012.03.062  1
2012 Hu CK, Ozlü N, Coughlin M, Steen JJ, Mitchison TJ. Plk1 negatively regulates PRC1 to prevent premature midzone formation before cytokinesis. Molecular Biology of the Cell. 23: 2702-11. PMID 22621898 DOI: 10.1091/mbc.E12-01-0058  1
2012 Hu CK, Coughlin M, Mitchison TJ. Midbody assembly and its regulation during cytokinesis. Molecular Biology of the Cell. 23: 1024-34. PMID 22278743 DOI: 10.1091/mbc.E11-08-0721  1
2012 Mitchison TJ. The proliferation rate paradox in antimitotic chemotherapy. Molecular Biology of the Cell. 23: 1-6. PMID 22210845 DOI: 10.1091/mbc.E10-04-0335  1
2012 Orth JD, Loewer A, Lahav G, Mitchison TJ. Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Molecular Biology of the Cell. 23: 567-76. PMID 22171325 DOI: 10.1091/mbc.E11-09-0781  1
2012 Kwiatkowski N, Deng X, Wang J, Tan L, Villa F, Santaguida S, Huang HC, Mitchison T, Musacchio A, Gray N. Selective aurora kinase inhibitors identified using a taxol-induced checkpoint sensitivity screen. Acs Chemical Biology. 7: 185-96. PMID 21992004 DOI: 10.1021/cb200305u  1
2012 Dumont S, Mitchison TJ. Mechanical forces in mitosis Comprehensive Biophysics. 4: 298-320. DOI: 10.1016/B978-0-12-374920-8.00419-7  1
2011 Akhtar A, Fuchs E, Mitchison T, Shaw RJ, St Johnston D, Strasser A, Taylor S, Walczak C, Zerial M. A decade of molecular cell biology: achievements and challenges. Nature Reviews. Molecular Cell Biology. 12: 669-74. PMID 21941276 DOI: 10.1038/nrm3187  1
2011 Tang Y, Orth JD, Xie T, Mitchison TJ. Rapid induction of apoptosis during Kinesin-5 inhibitor-induced mitotic arrest in HL60 cells. Cancer Letters. 310: 15-24. PMID 21782324 DOI: 10.1016/j.canlet.2011.05.024  1
2011 Groen AC, Coughlin M, Mitchison TJ. Microtubule assembly in meiotic extract requires glycogen. Molecular Biology of the Cell. 22: 3139-51. PMID 21737678 DOI: 10.1091/mbc.E11-02-0158  1
2011 Orth JD, Kohler RH, Foijer F, Sorger PK, Weissleder R, Mitchison TJ. Analysis of mitosis and antimitotic drug responses in tumors by in vivo microscopy and single-cell pharmacodynamics. Cancer Research. 71: 4608-16. PMID 21712408 DOI: 10.1158/0008-5472.CAN-11-0412  1
2011 Garner EC, Bernard R, Wang W, Zhuang X, Rudner DZ, Mitchison T. Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis. Science (New York, N.Y.). 333: 222-5. PMID 21636745 DOI: 10.1126/science.1203285  1
2011 Field CM, Wühr M, Anderson GA, Kueh HY, Strickland D, Mitchison TJ. Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos. Journal of Cell Science. 124: 2086-95. PMID 21610091 DOI: 10.1242/jcs.082263  1
2011 Hu CK, Coughlin M, Field CM, Mitchison TJ. KIF4 regulates midzone length during cytokinesis. Current Biology : Cb. 21: 815-24. PMID 21565503 DOI: 10.1016/j.cub.2011.04.019  1
2011 Shi J, Zhou Y, Huang HC, Mitchison TJ. Navitoclax (ABT-263) accelerates apoptosis during drug-induced mitotic arrest by antagonizing Bcl-xL. Cancer Research. 71: 4518-26. PMID 21546570 DOI: 10.1158/0008-5472.CAN-10-4336  1
2011 Brangwynne CP, Mitchison TJ, Hyman AA. Active liquid-like behavior of nucleoli determines their size and shape in Xenopus laevis oocytes. Proceedings of the National Academy of Sciences of the United States of America. 108: 4334-9. PMID 21368180 DOI: 10.1073/pnas.1017150108  1
2010 Huang HC, Mitchison TJ, Shi J. Stochastic competition between mechanistically independent slippage and death pathways determines cell fate during mitotic arrest. Plos One. 5: e15724. PMID 21203573 DOI: 10.1371/journal.pone.0015724  1
2010 Mitchison TJ. Remaining mysteries of the cytoplasm. Molecular Biology of the Cell. 21: 3811-2. PMID 21079024 DOI: 10.1091/mbc.E10-02-0084  1
2010 Wühr M, Tan ES, Parker SK, Detrich HW, Mitchison TJ. A model for cleavage plane determination in early amphibian and fish embryos. Current Biology : Cb. 20: 2040-5. PMID 21055946 DOI: 10.1016/j.cub.2010.10.024  1
2010 Kueh HY, Brieher WM, Mitchison TJ. Quantitative analysis of actin turnover in Listeria comet tails: evidence for catastrophic filament turnover. Biophysical Journal. 99: 2153-62. PMID 20923649 DOI: 10.1016/j.bpj.2010.07.038  1
2010 Huang HC, Shi J, Orth JD, Mitchison TJ. Cell death when the SAC is out of commission. Cell Cycle (Georgetown, Tex.). 9: 2049-50. PMID 20559025 DOI: 10.4161/cc.9.11.11918  1
2010 Martin DS, Fathi R, Mitchison TJ, Gelles J. FRET measurements of kinesin neck orientation reveal a structural basis for processivity and asymmetry. Proceedings of the National Academy of Sciences of the United States of America. 107: 5453-8. PMID 20212149 DOI: 10.1073/pnas.0914924107  0.52
2010 Gatlin JC, Matov A, Danuser G, Mitchison TJ, Salmon ED. Directly probing the mechanical properties of the spindle and its matrix. The Journal of Cell Biology. 188: 481-9. PMID 20176922 DOI: 10.1083/jcb.200907110  1
2010 Mitchison TJ, Mitchison HM. Cell biology: How cilia beat. Nature. 463: 308-9. PMID 20090745 DOI: 10.1038/463308a  1
2010 Needleman DJ, Groen A, Ohi R, Maresca T, Mirny L, Mitchison T. Fast microtubule dynamics in meiotic spindles measured by single molecule imaging: evidence that the spindle environment does not stabilize microtubules. Molecular Biology of the Cell. 21: 323-33. PMID 19940016 DOI: 10.1091/mbc.E09-09-0816  1
2010 Ozlü N, Monigatti F, Renard BY, Field CM, Steen H, Mitchison TJ, Steen JJ. Binding partner switching on microtubules and aurora-B in the mitosis to cytokinesis transition. Molecular & Cellular Proteomics : McP. 9: 336-50. PMID 19786723 DOI: 10.1074/mcp.M900308-MCP200  1
2009 Dumont S, Mitchison TJ. Force and length in the mitotic spindle. Current Biology : Cb. 19: R749-61. PMID 19906577 DOI: 10.1016/j.cub.2009.07.028  1
2009 Tsui M, Xie T, Orth JD, Carpenter AE, Rudnicki S, Kim S, Shamu CE, Mitchison TJ. An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. Plos One. 4: e7339. PMID 19802393 DOI: 10.1371/journal.pone.0007339  1
2009 Huang HC, Shi J, Orth JD, Mitchison TJ. Evidence that mitotic exit is a better cancer therapeutic target than spindle assembly. Cancer Cell. 16: 347-58. PMID 19800579 DOI: 10.1016/j.ccr.2009.08.020  1
2009 Chang P, Coughlin M, Mitchison TJ. Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly. Molecular Biology of the Cell. 20: 4575-85. PMID 19759176 DOI: 10.1091/mbc.E09-06-0477  1
2009 Kueh HY, Mitchison TJ. Structural plasticity in actin and tubulin polymer dynamics. Science (New York, N.Y.). 325: 960-3. PMID 19696342 DOI: 10.1126/science.1168823  1
2009 Charras GT, Mitchison TJ, Mahadevan L. Animal cell hydraulics. Journal of Cell Science. 122: 3233-41. PMID 19690051 DOI: 10.1242/jcs.049262  1
2009 Feng Y, Mitchison TJ, Bender A, Young DW, Tallarico JA. Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds. Nature Reviews. Drug Discovery. 8: 567-78. PMID 19568283 DOI: 10.1038/nrd2876  1
2009 Maresca TJ, Groen AC, Gatlin JC, Ohi R, Mitchison TJ, Salmon ED. Spindle assembly in the absence of a RanGTP gradient requires localized CPC activity. Current Biology : Cb. 19: 1210-5. PMID 19540121 DOI: 10.1016/j.cub.2009.05.061  1
2009 Dumont S, Mitchison TJ. Compression regulates mitotic spindle length by a mechanochemical switch at the poles. Current Biology : Cb. 19: 1086-95. PMID 19540117 DOI: 10.1016/j.cub.2009.05.056  1
2009 Needleman DJ, Xu Y, Mitchison TJ. Pin-hole array correlation imaging: highly parallel fluorescence correlation spectroscopy. Biophysical Journal. 96: 5050-9. PMID 19527665 DOI: 10.1016/j.bpj.2009.03.023  1
2009 Niethammer P, Grabher C, Look AT, Mitchison TJ. A tissue-scale gradient of hydrogen peroxide mediates rapid wound detection in zebrafish. Nature. 459: 996-9. PMID 19494811 DOI: 10.1038/nature08119  1
2009 Wühr M, Mitchison TJ, Field CM. Size and speed go hand in hand in cytokinesis. Cell. 137: 798-800. PMID 19490886 DOI: 10.1016/j.cell.2009.05.012  1
2009 Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ. Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly. Molecular Biology of the Cell. 20: 2766-73. PMID 19369413 DOI: 10.1091/mbc.E09-01-0043  1
2009 Wühr M, Dumont S, Groen AC, Needleman DJ, Mitchison TJ. How does a millimeter-sized cell find its center? Cell Cycle (Georgetown, Tex.). 8: 1115-21. PMID 19282671  1
2009 Gatlin JC, Matov A, Groen AC, Needleman DJ, Maresca TJ, Danuser G, Mitchison TJ, Salmon ED. Spindle fusion requires dynein-mediated sliding of oppositely oriented microtubules. Current Biology : Cb. 19: 287-96. PMID 19230671 DOI: 10.1016/j.cub.2009.01.055  1
2008 Orth JD, Tang Y, Shi J, Loy CT, Amendt C, Wilm C, Zenke FT, Mitchison TJ. Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate. Molecular Cancer Therapeutics. 7: 3480-9. PMID 18974392 DOI: 10.1158/1535-7163.MCT-08-0684  1
2008 Maloney KN, Fujita M, Eggert US, Schroeder FC, Field CM, Mitchison TJ, Clardy J. Actin-aggregating cucurbitacins from Physocarpus capitatus. Journal of Natural Products. 71: 1927-9. PMID 18959442 DOI: 10.1021/np8005259  1
2008 Wühr M, Mitchison TJ, Field CM. Mitosis: new roles for myosin-X and actin at the spindle. Current Biology : Cb. 18: R912-4. PMID 18957236 DOI: 10.1016/j.cub.2008.08.043  1
2008 Kueh HY, Brieher WM, Mitchison TJ. Dynamic stabilization of actin filaments. Proceedings of the National Academy of Sciences of the United States of America. 105: 16531-6. PMID 18931306 DOI: 10.1073/pnas.0807394105  1
2008 Wühr M, Chen Y, Dumont S, Groen AC, Needleman DJ, Salic A, Mitchison TJ. Evidence for an upper limit to mitotic spindle length. Current Biology : Cb. 18: 1256-61. PMID 18718761 DOI: 10.1016/j.cub.2008.07.092  1
2008 Kueh HY, Charras GT, Mitchison TJ, Brieher WM. Actin disassembly by cofilin, coronin, and Aip1 occurs in bursts and is inhibited by barbed-end cappers. The Journal of Cell Biology. 182: 341-53. PMID 18663144 DOI: 10.1083/jcb.200801027  1
2008 Groen AC, Needleman D, Brangwynne C, Gradinaru C, Fowler B, Mazitschek R, Mitchison TJ. A novel small-molecule inhibitor reveals a possible role of kinesin-5 in anastral spindle-pole assembly. Journal of Cell Science. 121: 2293-300. PMID 18559893 DOI: 10.1242/jcs.024018  1
2008 Shi J, Orth JD, Mitchison T. Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5 Cancer Research. 68: 3269-3276. PMID 18451153 DOI: 10.1158/0008-5472.CAN-07-6699  1
2008 Hu CK, Coughlin M, Field CM, Mitchison TJ. Cell polarization during monopolar cytokinesis. The Journal of Cell Biology. 181: 195-202. PMID 18411311 DOI: 10.1083/jcb.200711105  1
2008 Niethammer P, Kueh HY, Mitchison TJ. Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm. Current Biology : Cb. 18: 586-91. PMID 18406136 DOI: 10.1016/j.cub.2008.03.038  1
2008 Mitchison TJ, Charras GT, Mahadevan L. Implications of a poroelastic cytoplasm for the dynamics of animal cell shape. Seminars in Cell & Developmental Biology. 19: 215-23. PMID 18395478 DOI: 10.1016/j.semcdb.2008.01.008  1
2008 Salic A, Mitchison TJ. A chemical method for fast and sensitive detection of DNA synthesis in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 2415-20. PMID 18272492 DOI: 10.1073/pnas.0712168105  1
2008 Galkin VE, Orlova A, Brieher W, Kueh HY, Mitchison TJ, Egelman EH. Coronin-1A stabilizes F-actin by bridging adjacent actin protomers and stapling opposite strands of the actin filament. Journal of Molecular Biology. 376: 607-13. PMID 18177666 DOI: 10.1016/j.jmb.2007.12.007  1
2008 Young DW, Bender A, Hoyt J, McWhinnie E, Chirn GW, Tao CY, Tallarico JA, Labow M, Jenkins JL, Mitchison TJ, Feng Y. Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nature Chemical Biology. 4: 59-68. PMID 18066055 DOI: 10.1038/nchembio.2007.53  1
2008 Charras GT, Coughlin M, Mitchison TJ, Mahadevan L. Life and times of a cellular bleb. Biophysical Journal. 94: 1836-53. PMID 17921219 DOI: 10.1529/biophysj.107.113605  1
2007 Burbank KS, Mitchison TJ, Fisher DS. Slide-and-cluster models for spindle assembly. Current Biology : Cb. 17: 1373-83. PMID 17702580 DOI: 10.1016/j.cub.2007.07.058  1
2007 Vrabioiu AM, Mitchison TJ. Symmetry of septin hourglass and ring structures. Journal of Molecular Biology. 372: 37-49. PMID 17628594 DOI: 10.1016/j.jmb.2007.05.100  1
2007 Ohi R, Burbank K, Liu Q, Mitchison TJ. Nonredundant functions of Kinesin-13s during meiotic spindle assembly. Current Biology : Cb. 17: 953-9. PMID 17509883 DOI: 10.1016/j.cub.2007.04.057  1
2006 Charras GT, Hu CK, Coughlin M, Mitchison TJ. Reassembly of contractile actin cortex in cell blebs. The Journal of Cell Biology. 175: 477-90. PMID 17088428 DOI: 10.1083/jcb.200602085  1
2006 Burbank KS, Groen AC, Perlman ZE, Fisher DS, Mitchison TJ. A new method reveals microtubule minus ends throughout the meiotic spindle. The Journal of Cell Biology. 175: 369-75. PMID 17088423 DOI: 10.1083/jcb.200511112  1
2006 Ribbeck K, Mitchison TJ. Meiotic spindle: sculpted by severing. Current Biology : Cb. 16: R923-5. PMID 17084690 DOI: 10.1016/j.cub.2006.09.048  1
2006 Brieher WM, Kueh HY, Ballif BA, Mitchison TJ. Rapid actin monomer-insensitive depolymerization of Listeria actin comet tails by cofilin, coronin, and Aip1. The Journal of Cell Biology. 175: 315-24. PMID 17060499 DOI: 10.1083/jcb.200603149  1
2006 Vrabioiu AM, Mitchison TJ. Structural insights into yeast septin organization from polarized fluorescence microscopy. Nature. 443: 466-9. PMID 17006515 DOI: 10.1038/nature05109  1
2006 Eggert US, Field CM, Mitchison TJ. Small molecules in an RNAi world. Molecular Biosystems. 2: 93-6. PMID 16880926 DOI: 10.1039/b515335b  1
2006 Burbank KS, Mitchison TJ. Microtubule dynamic instability. Current Biology : Cb. 16: R516-7. PMID 16860721 DOI: 10.1016/j.cub.2006.06.044  1
2006 Eggert US, Mitchison TJ, Field CM. Animal cytokinesis: from parts list to mechanisms. Annual Review of Biochemistry. 75: 543-66. PMID 16756502 DOI: 10.1146/annurev.biochem.74.082803.133425  1
2006 Eggert US, Mitchison TJ. Small molecule screening by imaging. Current Opinion in Chemical Biology. 10: 232-7. PMID 16682248 DOI: 10.1016/j.cbpa.2006.04.010  1
2006 Ribbeck K, Groen AC, Santarella R, Bohnsack MT, Raemaekers T, Köcher T, Gentzel M, Görlich D, Wilm M, Carmeliet G, Mitchison TJ, Ellenberg J, Hoenger A, Mattaj IW. NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Molecular Biology of the Cell. 17: 2646-60. PMID 16571672 DOI: 10.1091/mbc.E05-12-1178  1
2006 De Wall SL, Painter C, Stone JD, Bandaranayake R, Wiley DC, Mitchison TJ, Stern LJ, DeDecker BS. Noble metals strip peptides from class II MHC proteins. Nature Chemical Biology. 2: 197-201. PMID 16505807 DOI: 10.1038/nchembio773  1
2006 Maliga Z, Mitchison TJ. Small-molecule and mutational analysis of allosteric Eg5 inhibition by monastrol. Bmc Chemical Biology. 6: 2. PMID 16504166 DOI: 10.1186/1472-6769-6-2  1
2005 Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chemical Biology. 1: 112-9. PMID 16408008 DOI: 10.1038/nchembio711  1
2005 Chang P, Coughlin M, Mitchison TJ. Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function. Nature Cell Biology. 7: 1133-9. PMID 16244666 DOI: 10.1038/ncb1322  0.84
2005 Mahadevan L, Mitchison TJ. Cell biology: powerful curves. Nature. 435: 895-7. PMID 15959501 DOI: 10.1038/435895a  1
2005 Dorer RK, Zhong S, Tallarico JA, Wong WH, Mitchison TJ, Murray AW. A small-molecule inhibitor of Mps1 blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes. Current Biology : Cb. 15: 1070-6. PMID 15936280 DOI: 10.1016/j.cub.2005.05.020  1
2005 Charras GT, Yarrow JC, Horton MA, Mahadevan L, Mitchison TJ. Non-equilibration of hydrostatic pressure in blebbing cells. Nature. 435: 365-9. PMID 15902261 DOI: 10.1038/nature03550  1
2005 Mitchison TJ. Mechanism and function of poleward flux in Xenopus extract meiotic spindles. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 360: 623-9. PMID 15897184 DOI: 10.1098/rstb.2004.1616  1
2005 Yarrow JC, Totsukawa G, Charras GT, Mitchison TJ. Screening for cell migration inhibitors via automated microscopy reveals a Rho-kinase inhibitor. Chemistry & Biology. 12: 385-95. PMID 15797222 DOI: 10.1016/j.chembiol.2005.01.015  1
2005 Mitchison TJ, Maddox P, Gaetz J, Groen A, Shirasu M, Desai A, Salmon ED, Kapoor TM. Roles of polymerization dynamics, opposed motors, and a tensile element in governing the length of Xenopus extract meiotic spindles. Molecular Biology of the Cell. 16: 3064-76. PMID 15788560 DOI: 10.1091/mbc.E05-02-0174  1
2005 Chang LJ, Liu X, He J. Lentiviral siRNAs targeting multiple highly conserved RNA sequences of human immunodeficiency virus type 1. Gene Therapy. 12: 1133-44. PMID 15750613 DOI: 10.1038/sj.gt.3302509  1
2005 Perlman ZE, Mitchison TJ, Mayer TU. High-content screening and profiling of drug activity in an automated centrosome-duplication assay. Chembiochem : a European Journal of Chemical Biology. 6: 145-51. PMID 15568197 DOI: 10.1002/cbic.200400266  1
2005 Mitchison TJ. Small-molecule screening and profiling by using automated microscopy. Chembiochem : a European Journal of Chemical Biology. 6: 33-9. PMID 15568196 DOI: 10.1002/cbic.200400272  1
2005 Valentine MT, Perlman ZE, Mitchison TJ, Weitz DA. Mechanical properties of Xenopus egg cytoplasmic extracts. Biophysical Journal. 88: 680-9. PMID 15501931 DOI: 10.1529/biophysj.104.048025  1
2005 Straight AF, Field CM, Mitchison TJ. Anillin binds nonmuscle myosin II and regulates the contractile ring. Molecular Biology of the Cell. 16: 193-201. PMID 15496454 DOI: 10.1091/mbc.E04-08-0758  1
2005 Lucas-Lopez C, Patterson S, Blum T, Straight AF, Toth J, Slawin AMZ, Mitchison TJ, Sellers JR, Westwood NJ. Absolute stereochemical assignment and fluorescence tuning of the small molecule tool, (-)-blebbistatin European Journal of Organic Chemistry. 1736-1740. DOI: 10.1002/ejoc.200500103  1
2004 Miyamoto DT, Perlman ZE, Burbank KS, Groen AC, Mitchison TJ. The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles. The Journal of Cell Biology. 167: 813-8. PMID 15583027 DOI: 10.1083/jcb.200407126  1
2004 Chang P, Jacobson MK, Mitchison TJ. Poly(ADP-ribose) is required for spindle assembly and structure. Nature. 432: 645-9. PMID 15577915 DOI: 10.1038/nature03061  1
2004 Eggert US, Kiger AA, Richter C, Perlman ZE, Perrimon N, Mitchison TJ, Field CM. Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. Plos Biology. 2: e379. PMID 15547975 DOI: 10.1371/journal.pbio.0020379  1
2004 Ramamurthy B, Yengo CM, Straight AF, Mitchison TJ, Sweeney HL. Kinetic mechanism of blebbistatin inhibition of nonmuscle myosin IIb. Biochemistry. 43: 14832-9. PMID 15544354 DOI: 10.1021/bi0490284  1
2004 Perlman ZE, Slack MD, Feng Y, Mitchison TJ, Wu LF, Altschuler SJ. Multidimensional drug profiling by automated microscopy. Science (New York, N.Y.). 306: 1194-8. PMID 15539606 DOI: 10.1126/science.1100709  1
2004 Shirasu-Hiza M, Perlman ZE, Wittmann T, Karsenti E, Mitchison TJ. Eg5 causes elongation of meiotic spindles when flux-associated microtubule depolymerization is blocked. Current Biology : Cb. 14: 1941-5. PMID 15530396 DOI: 10.1016/j.cub.2004.10.029  1
2004 Groen AC, Cameron LA, Coughlin M, Miyamoto DT, Mitchison TJ, Ohi R. XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly. Current Biology : Cb. 14: 1801-11. PMID 15498487 DOI: 10.1016/j.cub.2004.10.002  1
2004 Lawrence CJ, Dawe RK, Christie KR, Cleveland DW, Dawson SC, Endow SA, Goldstein LS, Goodson HV, Hirokawa N, Howard J, Malmberg RL, McIntosh JR, Miki H, Mitchison TJ, Okada Y, et al. A standardized kinesin nomenclature. The Journal of Cell Biology. 167: 19-22. PMID 15479732 DOI: 10.1083/jcb.200408113  1
2004 Mitchison TJ, Maddox P, Groen A, Cameron L, Perlman Z, Ohi R, Desai A, Salmon ED, Kapoor TM. Bipolarization and poleward flux correlate during Xenopus extract spindle assembly. Molecular Biology of the Cell. 15: 5603-15. PMID 15385629 DOI: 10.1091/mbc.E04-05-0440  1
2004 Yarrow JC, Perlman ZE, Westwood NJ, Mitchison TJ. A high-throughput cell migration assay using scratch wound healing, a comparison of image-based readout methods. Bmc Biotechnology. 4: 21. PMID 15357872 DOI: 10.1186/1472-6750-4-21  1
2004 Salic A, Waters JC, Mitchison TJ. Vertebrate shugoshin links sister centromere cohesion and kinetochore microtubule stability in mitosis. Cell. 118: 567-78. PMID 15339662 DOI: 10.1016/j.cell.2004.08.016  1
2004 Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D. Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proceedings of the National Academy of Sciences of the United States of America. 101: 11821-6. PMID 15289600 DOI: 10.1073/pnas.0404439101  1
2004 Miller SC, Mitchison TJ. Synthesis and phenotypic screening of a Guanine-mimetic library. Chembiochem : a European Journal of Chemical Biology. 5: 1010-2. PMID 15239063 DOI: 10.1002/cbic.200400039  1
2004 Valentine MT, Perlman ZE, Gardel ML, Shin JH, Matsudaira P, Mitchison TJ, Weitz DA. Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials. Biophysical Journal. 86: 4004-14. PMID 15189896 DOI: 10.1529/biophysj.103.037812  1
2004 Carey KL, Westwood NJ, Mitchison TJ, Ward GE. A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii. Proceedings of the National Academy of Sciences of the United States of America. 101: 7433-8. PMID 15123807 DOI: 10.1073/pnas.0307769101  1
2004 Brieher WM, Coughlin M, Mitchison TJ. Fascin-mediated propulsion of Listeria monocytogenes independent of frequent nucleation by the Arp2/3 complex. The Journal of Cell Biology. 165: 233-42. PMID 15117967 DOI: 10.1083/jcb.200311040  1
2004 Ohi R, Sapra T, Howard J, Mitchison TJ. Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation. Molecular Biology of the Cell. 15: 2895-906. PMID 15064354 DOI: 10.1091/mbc.E04-02-0082  1
2004 Corcoran LJ, Mitchison TJ, Liu Q. A novel action of histone deacetylase inhibitors in a protein aggresome disease model. Current Biology : Cb. 14: 488-92. PMID 15043813 DOI: 10.1016/j.cub.2004.03.003  1
2004 Tirnauer JS, Salmon ED, Mitchison TJ. Microtubule plus-end dynamics in Xenopus egg extract spindles. Molecular Biology of the Cell. 15: 1776-84. PMID 14767058 DOI: 10.1091/mbc.E03-11-0824  1
2004 Romberg L, Mitchison TJ. Rate-limiting guanosine 5'-triphosphate hydrolysis during nucleotide turnover by FtsZ, a prokaryotic tubulin homologue involved in bacterial cell division. Biochemistry. 43: 282-8. PMID 14705956 DOI: 10.1021/bi035465r  1
2004 Vrabioiu AM, Gerber SA, Gygi SP, Field CM, Mitchison TJ. The majority of the Saccharomyces cerevisiae septin complexes do not exchange guanine nucleotides. The Journal of Biological Chemistry. 279: 3111-8. PMID 14597621 DOI: 10.1074/jbc.M310941200  1
2003 Miyamoto DT, Perlman ZE, Mitchison TJ, Shirasu-Hiza M. Dynamics of the mitotic spindle--potential therapeutic targets. Progress in Cell Cycle Research. 5: 349-60. PMID 14593729  1
2003 Ohi R, Coughlin ML, Lane WS, Mitchison TJ. An inner centromere protein that stimulates the microtubule depolymerizing activity of a KinI kinesin. Developmental Cell. 5: 309-21. PMID 12919681 DOI: 10.1016/S1534-5807(03)00229-6  1
2003 Canman JC, Cameron LA, Maddox PS, Straight A, Tirnauer JS, Mitchison TJ, Fang G, Kapoor TM, Salmon ED. Determining the position of the cell division plane. Nature. 424: 1074-8. PMID 12904818 DOI: 10.1038/nature01860  1
2003 Maddox P, Straight A, Coughlin P, Mitchison TJ, Salmon ED. Direct observation of microtubule dynamics at kinetochores in Xenopus extract spindles: implications for spindle mechanics. The Journal of Cell Biology. 162: 377-82. PMID 12900391 DOI: 10.1083/jcb.200301088  1
2003 Yarrow JC, Lechler T, Li R, Mitchison TJ. Rapid de-localization of actin leading edge components with BDM treatment. Bmc Cell Biology. 4: 5. PMID 12783627 DOI: 10.1186/1471-2121-4-5  1
2003 Yarrow JC, Feng Y, Perlman ZE, Kirchhausen T, Mitchison TJ. Phenotypic screening of small molecule libraries by high throughput cell imaging. Combinatorial Chemistry & High Throughput Screening. 6: 279-86. PMID 12769670  1
2003 Straight AF, Cheung A, Limouze J, Chen I, Westwood NJ, Sellers JR, Mitchison TJ. Dissecting temporal and spatial control of cytokinesis with a myosin II Inhibitor. Science (New York, N.Y.). 299: 1743-7. PMID 12637748 DOI: 10.1126/science.1081412  1
2003 McGrath JL, Eungdamrong NJ, Fisher CI, Peng F, Mahadevan L, Mitchison TJ, Kuo SC. The force-velocity relationship for the actin-based motility of Listeria monocytogenes. Current Biology : Cb. 13: 329-32. PMID 12593799 DOI: 10.1016/S0960-9822(03)00051-4  1
2002 Mitchison TJ. Probing cell division with "chemical genetics". Harvey Lectures. 98: 19-40. PMID 16033156  1
2002 Peterson JR, Mitchison TJ. Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. Chemistry & Biology. 9: 1275-85. PMID 12498880 DOI: 10.1016/S1074-5521(02)00284-3  1
2002 Kinoshita M, Field CM, Coughlin ML, Straight AF, Mitchison TJ. Self- and actin-templated assembly of Mammalian septins. Developmental Cell. 3: 791-802. PMID 12479805 DOI: 10.1016/S1534-5807(02)00366-0  1
2002 Tirnauer JS, Canman JC, Salmon ED, Mitchison TJ. EB1 targets to kinetochores with attached, polymerizing microtubules. Molecular Biology of the Cell. 13: 4308-16. PMID 12475954 DOI: 10.1091/mbc.E02-04-0236  1
2002 Macara IG, Baldarelli R, Field CM, Glotzer M, Hayashi Y, Hsu SC, Kennedy MB, Kinoshita M, Longtine M, Low C, Maltais LJ, McKenzie L, Mitchison TJ, Nishikawa T, Noda M, et al. Mammalian septins nomenclature. Molecular Biology of the Cell. 13: 4111-3. PMID 12475938 DOI: 10.1091/mbc.E02-07-0438  1
2002 Mitchison TJ, Field CM. Cytoskeleton: what does GTP do for septins? Current Biology : Cb. 12: R788-90. PMID 12445407 DOI: 10.1016/S0960-9822(02)01295-2  1
2002 Walczak CE, Gan EC, Desai A, Mitchison TJ, Kline-Smith SL. The microtubule-destabilizing kinesin XKCM1 is required for chromosome positioning during spindle assembly. Current Biology : Cb. 12: 1885-9. PMID 12419191 DOI: 10.1016/S0960-9822(02)01227-7  1
2002 Tirnauer JS, Grego S, Salmon ED, Mitchison TJ. EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. Molecular Biology of the Cell. 13: 3614-26. PMID 12388761 DOI: 10.1091/mbc.E02-04-0210  1
2002 Maddox P, Desai A, Oegema K, Mitchison TJ, Salmon ED. Poleward microtubule flux is a major component of spindle dynamics and anaphase a in mitotic Drosophila embryos. Current Biology : Cb. 12: 1670-4. PMID 12361570 DOI: 10.1016/S0960-9822(02)01183-1  1
2002 Maliga Z, Kapoor TM, Mitchison TJ. Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5. Chemistry & Biology. 9: 989-96. PMID 12323373 DOI: 10.1016/S1074-5521(02)00212-0  1
2002 Watanabe N, Mitchison TJ. Single-molecule speckle analysis of actin filament turnover in lamellipodia. Science (New York, N.Y.). 295: 1083-6. PMID 11834838 DOI: 10.1126/science.1067470  1
2002 Cheung A, Dantzig JA, Hollingworth S, Baylor SM, Goldman YE, Mitchison TJ, Straight AF. A small-molecule inhibitor of skeletal muscle myosin II. Nature Cell Biology. 4: 83-8. PMID 11744924 DOI: 10.1038/ncb734  0.52
2002 McDonald WH, Ohi R, Miyamoto DT, Mitchison TJ, Yates JR. Comparison of three directly coupled HPLC MS/MS strategies for identification of proteins from complex mixtures: Single-dimension LC-MS/MS, 2-phase MudPIT, and 3-phase MudPIT International Journal of Mass Spectrometry. 219: 245-251. DOI: 10.1016/S1387-3806(02)00563-8  1
2001 Kapoor TM, Mitchison TJ. Eg5 is static in bipolar spindles relative to tubulin: evidence for a static spindle matrix. The Journal of Cell Biology. 154: 1125-33. PMID 11564753 DOI: 10.1083/jcb.200106011  1
2001 Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proceedings of the National Academy of Sciences of the United States of America. 98: 10624-9. PMID 11553809 DOI: 10.1073/pnas.201393198  1
2001 Mitchison TJ. Psychosine, cytokinesis, and orphan receptors. Unexpected connections. The Journal of Cell Biology. 153: F1-3. PMID 11309405  1
2001 Mitchison TJ, Salmon ED. Mitosis: a history of division. Nature Cell Biology. 3: E17-21. PMID 11146645 DOI: 10.1038/35050656  1
2000 Kapoor TM, Mayer TU, Coughlin ML, Mitchison TJ. Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. The Journal of Cell Biology. 150: 975-88. PMID 10973989 DOI: 10.1083/jcb.150.5.975  1
2000 Oegema K, Savoian MS, Mitchison TJ, Field CM. Functional analysis of a human homologue of the Drosophila actin binding protein anillin suggests a role in cytokinesis. The Journal of Cell Biology. 150: 539-52. PMID 10931866 DOI: 10.1083/jcb.150.3.539  1
2000 Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chemistry & Biology. 7: 275-86. PMID 10780927 DOI: 10.1016/S1074-5521(00)00101-0  1
2000 Taunton J, Rowning BA, Coughlin ML, Wu M, Moon RT, Mitchison TJ, Larabell CA. Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP. The Journal of Cell Biology. 148: 519-30. PMID 10662777 DOI: 10.1083/jcb.148.3.519  1
2000 Rotella DP, Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small-molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen Chemtracts. 13: 256-258.  1
1999 Maddox P, Desai A, Salmon ED, Mitchison TJ, Oogema K, Kapoor T, Matsumoto B, Inoué S. Dynamic confocal imaging of mitochondria in swimming Tetrahymena and of microtubule poleward flux in Xenopus extract spindles. The Biological Bulletin. 197: 263-5. PMID 10573847  1
1999 Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR. Spatial control of actin polymerization during neutrophil chemotaxis. Nature Cell Biology. 1: 75-81. PMID 10559877 DOI: 10.1038/10042  1
1999 Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science (New York, N.Y.). 286: 971-4. PMID 10542155 DOI: 10.1126/science.286.5441.971  1
1999 Kapoor TM, Mitchison TJ. Allele-specific activators and inhibitors for kinesin. Proceedings of the National Academy of Sciences of the United States of America. 96: 9106-11. PMID 10430903 DOI: 10.1073/pnas.96.16.9106  1
1999 Oegema K, Wiese C, Martin OC, Milligan RA, Iwamatsu A, Mitchison TJ, Zheng Y. Characterization of two related Drosophila gamma-tubulin complexes that differ in their ability to nucleate microtubules. The Journal of Cell Biology. 144: 721-33. PMID 10037793 DOI: 10.1083/jcb.144.4.721  1
1999 Desai A, Verma S, Mitchison TJ, Walczak CE. Kin I kinesins are microtubule-destabilizing enzymes. Cell. 96: 69-78. PMID 9989498 DOI: 10.1016/S0092-8674(00)80960-5  1
1999 Desai A, Murray A, Mitchison TJ, Walczak CE. The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro. Methods in Cell Biology. 61: 385-412. PMID 9891325  1
1999 Sharp DJ, McDonald KL, Brown HM, Matthies HJ, Walczak C, Vale RD, Mitchison TJ, Scholey JM. The bipolar kinesin, KLP61F, cross-links microtubules within interpolar microtubule bundles of Drosophila embryonic mitotic spindles. The Journal of Cell Biology. 144: 125-38. PMID 9885249 DOI: 10.1083/jcb.144.1.125  1
1998 Frazier JA, Wong ML, Longtine MS, Pringle JR, Mann M, Mitchison TJ, Field C. Polymerization of purified yeast septins: evidence that organized filament arrays may not be required for septin function. The Journal of Cell Biology. 143: 737-49. PMID 9813094 DOI: 10.1083/jcb.143.3.737  1
1998 Yoshihara HA, Chiellini G, Mitchison TJ, Scanlan TS. An efficient substitution reaction for the preparation of thyroid hormone analogues. Bioorganic & Medicinal Chemistry. 6: 1179-83. PMID 9784860 DOI: 10.1016/S0968-0896(98)00085-6  1
1998 Field CM, Oegema K, Zheng Y, Mitchison TJ, Walczak CE. Purification of cytoskeletal proteins using peptide antibodies. Methods in Enzymology. 298: 525-41. PMID 9751906 DOI: 10.1016/S0076-6879(98)98043-0  1
1998 Oegema K, Desai A, Wong ML, Mitchison TJ, Field CM. Purification and assay of a septin complex from Drosophila embryos. Methods in Enzymology. 298: 279-95. PMID 9751888 DOI: 10.1016/S0076-6879(98)98025-9  1
1998 Desai A, Mitchison TJ. Preparation and characterization of caged fluorescein tubulin. Methods in Enzymology. 298: 125-32. PMID 9751877 DOI: 10.1016/S0076-6879(98)98014-4  1
1998 Welch MD, Mitchison TJ. Purification and assay of the platelet Arp2/3 complex. Methods in Enzymology. 298: 52-61. PMID 9751871 DOI: 10.1016/S0076-6879(98)98008-9  1
1998 Desai A, Mitchison TJ. Tubulin and FtsZ structures: functional and therapeutic implications. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 20: 523-7. PMID 9722999 DOI: 10.1002/(SICI)1521-1878(199807)20:7<523::AID-BIES1>3.0.CO;2-L  1
1998 Walczak CE, Vernos I, Mitchison TJ, Karsenti E, Heald R. A model for the proposed roles of different microtubule-based motor proteins in establishing spindle bipolarity. Current Biology : Cb. 8: 903-13. PMID 9707401  1
1998 Mitchison TJ, Sawin KE, Theriot JA, Gee K, Mallavarapu A. Caged fluorescent probes. Methods in Enzymology. 291: 63-78. PMID 9661145 DOI: 10.1016/S0076-6879(98)91007-2  1
1998 Rosenblatt J, Mitchison TJ. Actin, cofilin and cognition. Nature. 393: 739-40. PMID 9655388 DOI: 10.1038/31597  1
1998 Welch MD, Rosenblatt J, Skoble J, Portnoy DA, Mitchison TJ. Interaction of human Arp2/3 complex and the Listeria monocytogenes ActA protein in actin filament nucleation. Science (New York, N.Y.). 281: 105-8. PMID 9651243 DOI: 10.1126/science.281.5373.105  1
1998 Desai A, Maddox PS, Mitchison TJ, Salmon ED. Anaphase A chromosome movement and poleward spindle microtubule flux occur At similar rates in Xenopus extract spindles. The Journal of Cell Biology. 141: 703-13. PMID 9566970 DOI: 10.1083/jcb.141.3.703  1
1997 Desai A, Mitchison TJ. Microtubule polymerization dynamics. Annual Review of Cell and Developmental Biology. 13: 83-117. PMID 9442869 DOI: 10.1146/annurev.cellbio.13.1.83  1
1997 Desai A, Deacon HW, Walczak CE, Mitchison TJ. A method that allows the assembly of kinetochore components onto chromosomes condensed in clarified Xenopus egg extracts. Proceedings of the National Academy of Sciences of the United States of America. 94: 12378-83. PMID 9356457 DOI: 10.1073/pnas.94.23.12378  1
1997 Welch MD, DePace AH, Verma S, Iwamatsu A, Mitchison TJ. The human Arp2/3 complex is composed of evolutionarily conserved subunits and is localized to cellular regions of dynamic actin filament assembly. The Journal of Cell Biology. 138: 375-84. PMID 9230079 DOI: 10.1083/jcb.138.2.375  1
1997 Oegema K, Mitchison TJ. Rappaport rules: cleavage furrow induction in animal cells. Proceedings of the National Academy of Sciences of the United States of America. 94: 4817-20. PMID 9144146  1
1997 Rosenblatt J, Agnew BJ, Abe H, Bamburg JR, Mitchison TJ. Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails. The Journal of Cell Biology. 136: 1323-32. PMID 9087446 DOI: 10.1083/jcb.136.6.1323  1
1997 Cramer LP, Siebert M, Mitchison TJ. Identification of novel graded polarity actin filament bundles in locomoting heart fibroblasts: implications for the generation of motile force. The Journal of Cell Biology. 136: 1287-305. PMID 9087444 DOI: 10.1083/jcb.136.6.1287  1
1997 Walczak CE, Verma S, Mitchison TJ. XCTK2: a kinesin-related protein that promotes mitotic spindle assembly in Xenopus laevis egg extracts. The Journal of Cell Biology. 136: 859-70. PMID 9049251 DOI: 10.1083/jcb.136.4.859  1
1997 Cramer LP, Mitchison TJ. Investigation of the mechanism of retraction of the cell margin and rearward flow of nodules during mitotic cell rounding. Molecular Biology of the Cell. 8: 109-19. PMID 9017599  1
1997 Welch MD, Mallavarapu A, Rosenblatt J, Mitchison TJ. Actin dynamics in vivo. Current Opinion in Cell Biology. 9: 54-61. PMID 9013669 DOI: 10.1016/S0955-0674(97)80152-4  1
1997 Welch MD, Iwamatsu A, Mitchison TJ. Actin polymerization is induced by Arp2/3 protein complex at the surface of Listeria monocytogenes. Nature. 385: 265-9. PMID 9000076 DOI: 10.1038/385265a0  1
1996 Waters JC, Mitchison TJ, Rieder CL, Salmon ED. The kinetochore microtubule minus-end disassembly associated with poleward flux produces a force that can do work. Molecular Biology of the Cell. 7: 1547-58. PMID 8898361  0.88
1996 Walczak CE, Mitchison TJ. Kinesin-related proteins at mitotic spindle poles: function and regulation. Cell. 85: 943-6. PMID 8674121 DOI: 10.1016/S0092-8674(00)81295-7  1
1996 Field CM, al-Awar O, Rosenblatt J, Wong ML, Alberts B, Mitchison TJ. A purified Drosophila septin complex forms filaments and exhibits GTPase activity. The Journal of Cell Biology. 133: 605-16. PMID 8636235 DOI: 10.1083/jcb.133.3.605  1
1996 Mitchison TJ, Cramer LP. Actin-based cell motility and cell locomotion. Cell. 84: 371-9. PMID 8608590 DOI: 10.1016/S0092-8674(00)81281-7  1
1996 Walczak CE, Mitchison TJ, Desai A. XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell. 84: 37-47. PMID 8548824 DOI: 10.1016/S0092-8674(00)80991-5  1
1995 Desai A, Mitchison TJ. A new role for motor proteins as couplers to depolymerizing microtubules. The Journal of Cell Biology. 128: 1-4. PMID 7822407  1
1995 Sawin KE, Mitchison TJ. Mutations in the kinesin-like protein Eg5 disrupting localization to the mitotic spindle. Proceedings of the National Academy of Sciences of the United States of America. 92: 4289-93. PMID 7753799  1
1995 Hirano T, Mitchison TJ, Swedlow JR. The SMC family: from chromosome condensation to dosage compensation. Current Opinion in Cell Biology. 7: 329-36. PMID 7662362  0.52
1995 Cramer LP, Mitchison TJ. Myosin is involved in postmitotic cell spreading. The Journal of Cell Biology. 131: 179-89. PMID 7559774 DOI: 10.1083/jcb.131.1.179  1
1994 Theriot JA, Rosenblatt J, Portnoy DA, Goldschmidt-Clermont PJ, Mitchison TJ. Involvement of profilin in the actin-based motility of L. monocytogenes in cells and in cell-free extracts. Cell. 76: 505-17. PMID 8313471 DOI: 10.1016/0092-8674(94)90114-7  1
1994 Cramer LP, Mitchison TJ, Theriot JA. Actin-dependent motile forces and cell motility. Current Opinion in Cell Biology. 6: 82-6. PMID 8167030  1
1993 Theriot JA, Mitchison TJ. The three faces of profilin. Cell. 75: 835-8. PMID 8252619 DOI: 10.1016/0092-8674(93)90527-W  1
1993 Hyman AA, Mitchison TJ. An assay for the activity of microtubule-based motors on the kinetochores of isolated Chinese hamster ovary chromosomes. Methods in Cell Biology. 39: 267-76. PMID 8246803  0.84
1992 Theriot JA, Mitchison TJ. The nucleation-release model of actin filament dynamics in cell motility. Trends in Cell Biology. 2: 219-22. PMID 14731477 DOI: 10.1016/0962-8924(92)90298-2  1
1992 Theriot JA, Mitchison TJ, Tilney LG, Portnoy DA. The rate of actin-based motility of intracellular Listeria monocytogenes equals the rate of actin polymerization. Nature. 357: 257-60. PMID 1589024 DOI: 10.1038/357257a0  1
1992 Hyman AA, Salser S, Drechsel DN, Unwin N, Mitchison TJ. Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP. Molecular Biology of the Cell. 3: 1155-67. PMID 1421572  1
1992 Hyman AA, Middleton K, Centola M, Mitchison TJ, Carbon J. Microtubule-motor activity of a yeast centromere-binding protein complex. Nature. 359: 533-6. PMID 1406970 DOI: 10.1038/359533a0  1
1992 Theriot JA, Mitchison TJ. Comparison of actin and cell surface dynamics in motile fibroblasts. The Journal of Cell Biology. 119: 367-77. PMID 1400580 DOI: 10.1083/jcb.119.2.367  1
1991 Theriot JA, Mitchison TJ. Actin microfilament dynamics in locomoting cells. Nature. 352: 126-31. PMID 2067574 DOI: 10.1038/352126a0  1
1991 Hyman AA, Mitchison TJ. Two different microtubule-based motor activities with opposite polarities in kinetochores. Nature. 351: 206-11. PMID 2041567 DOI: 10.1038/351206a0  0.84
1991 Hyman AA, Mitchison TJ. Regulation of the direction of chromosome movement. Cold Spring Harbor Symposia On Quantitative Biology. 56: 745-50. PMID 1819521  0.84
1990 Belmont LD, Hyman AA, Sawin KE, Mitchison TJ. Real-time visualization of cell cycle-dependent changes in microtubule dynamics in cytoplasmic extracts. Cell. 62: 579-89. PMID 2379239 DOI: 10.1016/0092-8674(90)90022-7  1
1990 Hyman AA, Mitchison TJ. Modulation of microtubule stability by kinetochores in vitro. The Journal of Cell Biology. 110: 1607-16. PMID 2186046  0.84
1988 Koshland DE, Mitchison TJ, Kirschner MW. Polewards chromosome movement driven by microtubule depolymerization in vitro. Nature. 331: 499-504. PMID 3340202 DOI: 10.1038/331499a0  1
1987 Mitchison TJ, Kirschner MW. Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability. Cell Biophysics. 11: 35-55. PMID 2450668  1
1986 Mitchison TJ, Kirschner MW. Isolation of mammalian centrosomes. Methods in Enzymology. 134: 261-8. PMID 3821566  1
1985 Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation. The Journal of Cell Biology. 101: 766-77. PMID 4030894  1
1985 Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding. The Journal of Cell Biology. 101: 755-65. PMID 4030893  1
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