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Christopher Nicchitta - Publications

Affiliations: 
Duke University, Durham, NC 
Area:
Secretion, mRNA-ER association
Website:
http://www.cellbio.duke.edu/faculty/Nicchitta/LabSite/index.html

77 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Child JR, Chen Q, Reid DW, Jagannathan S, Nicchitta C. Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. Rna (New York, N.Y.). PMID 34244458 DOI: 10.1261/rna.078858.121  0.704
2020 Hannigan MM, Hoffman AM, Thompson W, Zheng T, Nicchitta CV. Quantitative proteomics links the LRRC59 interactome to mRNA translation on the ER membrane. Molecular & Cellular Proteomics : McP. PMID 32788342 DOI: 10.1074/mcp.RA120.002228  0.412
2019 Hoffman AM, Chen Q, Zheng T, Nicchitta CV. Heterogeneous translational landscape of the endoplasmic reticulum revealed by ribosome proximity labeling and transcriptome analysis. The Journal of Biological Chemistry. PMID 31004035 DOI: 10.1074/jbc.RA119.007996  0.387
2018 Hsu JC, Reid DW, Hoffman AM, Sarkar D, Nicchitta CV. Oncoprotein AEG-1 is an Endoplasmic Reticulum RNA Binding Protein Whose Interactome is Enriched In Organelle Resident Protein-Encoding mRNAs. Rna (New York, N.Y.). PMID 29438049 DOI: 10.1261/Rna.063313.117  0.36
2018 Reid DW, Campos RK, Child JR, Zheng T, Chan KWK, Bradrick SS, Vasudevan SG, Garcia-Blanco MA, Nicchitta CV. Dengue virus selectively annexes endoplasmic reticulum-associated translation machinery as a strategy for co-opting host cell protein synthesis. Journal of Virology. PMID 29321322 DOI: 10.1128/Jvi.01766-17  0.324
2016 Garcia-Blanco MA, Vasudevan SG, Bradrick SS, Nicchitta C. Flavivirus RNA transactions from viral entry to genome replication. Antiviral Research. PMID 27666184 DOI: 10.1016/J.Antiviral.2016.09.010  0.32
2016 Reid DW, Tay AS, Sundaram JR, Lee IC, Chen Q, George SE, Nicchitta CV, Shenolikar S. Complementary roles of GADD34- and CReP-containing eIF2α Phosphatases during the Unfolded Protein Response. Molecular and Cellular Biology. PMID 27161320 DOI: 10.1128/MCB.00190-16  0.362
2015 LaMonte G, Walzer KA, Lacsina J, Nicchitta C, Chi JT. Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum. Journal of Visualized Experiments : Jove. PMID 26709459 DOI: 10.3791/53214  0.783
2015 Reid DW, Nicchitta CV. LOCAL TRANSLATION. Comment on "Principles of ER cotranslational translocation revealed by proximity-specific ribosome profiling". Science (New York, N.Y.). 348: 1217. PMID 26068841 DOI: 10.1126/science.aaa7257  0.331
2015 Reid DW, Nicchitta CV. Diversity and selectivity in mRNA translation on the endoplasmic reticulum. Nature Reviews. Molecular Cell Biology. 16: 221-31. PMID 25735911 DOI: 10.1038/nrm3958  0.413
2014 Reid DW, Chen Q, Tay AS, Shenolikar S, Nicchitta CV. The unfolded protein response triggers selective mRNA release from the endoplasmic reticulum. Cell. 158: 1362-74. PMID 25215492 DOI: 10.1016/j.cell.2014.08.012  0.373
2014 Jagannathan S, Reid DW, Cox AH, Nicchitta CV. De novo translation initiation on membrane-bound ribosomes as a mechanism for localization of cytosolic protein mRNAs to the endoplasmic reticulum. Rna (New York, N.Y.). 20: 1489-98. PMID 25142066 DOI: 10.1261/Rna.045526.114  0.625
2014 Jagannathan S, Hsu JC, Reid DW, Chen Q, Thompson WJ, Moseley AM, Nicchitta CV. Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum. The Journal of Biological Chemistry. 289: 25907-24. PMID 25063809 DOI: 10.1074/Jbc.M114.580688  0.633
2013 Epple LM, Dodd RD, Merz AL, Dechkovskaia AM, Herring M, Winston BA, Lencioni AM, Russell RL, Madsen H, Nega M, Dusto NL, White J, Bigner DD, Nicchitta CV, Serkova NJ, et al. Induction of the unfolded protein response drives enhanced metabolism and chemoresistance in glioma cells. Plos One. 8: e73267. PMID 24039668 DOI: 10.1371/Journal.Pone.0073267  0.668
2013 Lampson BL, Pershing NL, Prinz JA, Lacsina JR, Marzluff WF, Nicchitta CV, MacAlpine DM, Counter CM. Rare codons regulate KRas oncogenesis. Current Biology : Cb. 23: 70-5. PMID 23246410 DOI: 10.1016/J.Cub.2012.11.031  0.79
2012 Lacsina JR, Marks OA, Liu X, Reid DW, Jagannathan S, Nicchitta CV. Premature translational termination products are rapidly degraded substrates for MHC class I presentation. Plos One. 7: e51968. PMID 23251665 DOI: 10.1371/Journal.Pone.0051968  0.802
2012 LaMonte G, Philip N, Reardon J, Lacsina JR, Majoros W, Chapman L, Thornburg CD, Telen MJ, Ohler U, Nicchitta CV, Haystead T, Chi JT. Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. Cell Host & Microbe. 12: 187-99. PMID 22901539 DOI: 10.1016/J.Chom.2012.06.007  0.757
2012 Duerfeldt AS, Peterson LB, Maynard JC, Ng CL, Eletto D, Ostrovsky O, Shinogle HE, Moore DS, Argon Y, Nicchitta CV, Blagg BS. Development of a Grp94 inhibitor. Journal of the American Chemical Society. 134: 9796-804. PMID 22642269 DOI: 10.1021/Ja303477G  0.715
2012 Reid DW, Nicchitta CV. Primary role for endoplasmic reticulum-bound ribosomes in cellular translation identified by ribosome profiling. The Journal of Biological Chemistry. 287: 5518-27. PMID 22199352 DOI: 10.1074/jbc.M111.312280  0.397
2011 Chen Q, Jagannathan S, Reid DW, Zheng T, Nicchitta CV. Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells. Molecular Biology of the Cell. 22: 2646-58. PMID 21613539 DOI: 10.1091/Mbc.E11-03-0239  0.601
2011 Lacsina JR, LaMonte G, Nicchitta CV, Chi JT. Polysome profiling of the malaria parasite Plasmodium falciparum. Molecular and Biochemical Parasitology. 179: 42-6. PMID 21605599 DOI: 10.1016/J.Molbiopara.2011.05.003  0.776
2011 Yewdell JW, Lacsina JR, Rechsteiner MC, Nicchitta CV. Out with the old, in with the new? Comparing methods for measuring protein degradation. Cell Biology International. 35: 457-62. PMID 21476986 DOI: 10.1042/Cbi20110055  0.791
2011 Jagannathan S, Nwosu C, Nicchitta CV. Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation. Methods in Molecular Biology (Clifton, N.J.). 714: 301-21. PMID 21431749 DOI: 10.1007/978-1-61779-005-8_19  0.623
2010 Jockheck-Clark AR, Bowers EV, Totonchy MB, Neubauer J, Pizzo SV, Nicchitta CV. Re-examination of CD91 function in GRP94 (glycoprotein 96) surface binding, uptake, and peptide cross-presentation. Journal of Immunology (Baltimore, Md. : 1950). 185: 6819-30. PMID 21048103 DOI: 10.4049/Jimmunol.1000448  0.783
2010 Maynard JC, Pham T, Zheng T, Jockheck-Clark A, Rankin HB, Newgard CB, Spana EP, Nicchitta CV. Gp93, the Drosophila GRP94 ortholog, is required for gut epithelial homeostasis and nutrient assimilation-coupled growth control. Developmental Biology. 339: 295-306. PMID 20044986 DOI: 10.1016/J.Ydbio.2009.12.023  0.786
2010 Lev A, Dimberu P, Das SR, Maynard JC, Nicchitta CV, Bennink JR, Yewdell JW. Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent (Journal of Immunology (2009) 183, (4205-4210)) Journal of Immunology. 185: 770. DOI: 10.4049/Jimmunol.1090046  0.705
2009 Lu Z, Zhou L, Killela P, Rasheed AB, Di C, Poe WE, McLendon RE, Bigner DD, Nicchitta C, Yan H. Glioblastoma proto-oncogene SEC61gamma is required for tumor cell survival and response to endoplasmic reticulum stress. Cancer Research. 69: 9105-11. PMID 19920201 DOI: 10.1158/0008-5472.Can-09-2775  0.329
2009 Lev A, Dimberu P, Das SR, Maynard JC, Nicchitta CV, Bennink JR, Yewdell JW. Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent. Journal of Immunology (Baltimore, Md. : 1950). 183: 4205-10. PMID 19752220 DOI: 10.4049/Jimmunol.0901828  0.739
2009 Huang QQ, Sobkoviak R, Jockheck-Clark AR, Shi B, Mandelin AM, Tak PP, Haines GK, Nicchitta CV, Pope RM. Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling. Journal of Immunology (Baltimore, Md. : 1950). 182: 4965-73. PMID 19342676 DOI: 10.4049/Jimmunol.0801563  0.757
2008 Lev A, Takeda K, Zanker D, Maynard JC, Dimberu P, Waffarn E, Gibbs J, Netzer N, Princiotta MF, Neckers L, Picard D, Nicchitta CV, Chen W, Reiter Y, Bennink JR, et al. The exception that reinforces the rule: crosspriming by cytosolic peptides that escape degradation. Immunity. 28: 787-98. PMID 18549799 DOI: 10.1016/J.Immuni.2008.04.015  0.75
2008 Tewalt EF, Maynard JC, Walters JJ, Schell AM, Berwin BL, Nicchitta CV, Norbury CC. Redundancy renders the glycoprotein 96 receptor scavenger receptor A dispensable for cross priming in vivo. Immunology. 125: 480-91. PMID 18489571 DOI: 10.1111/J.1365-2567.2008.02861.X  0.801
2008 Stephens SB, Dodd RD, Lerner RS, Pyhtila BM, Nicchitta CV. Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. Methods in Molecular Biology (Clifton, N.J.). 419: 197-214. PMID 18369985 DOI: 10.1007/978-1-59745-033-1_14  0.799
2008 Pyhtila B, Zheng T, Lager PJ, Keene JD, Reedy MC, Nicchitta CV. Signal sequence- and translation-independent mRNA localization to the endoplasmic reticulum. Rna (New York, N.Y.). 14: 445-53. PMID 18192611 DOI: 10.1261/Rna.721108  0.624
2008 Stephens SB, Nicchitta CV. Divergent regulation of protein synthesis in the cytosol and endoplasmic reticulum compartments of mammalian cells. Molecular Biology of the Cell. 19: 623-32. PMID 18077556 DOI: 10.1091/Mbc.E07-07-0677  0.755
2007 Stephens SB, Nicchitta CV. In vitro and tissue culture methods for analysis of translation initiation on the endoplasmic reticulum. Methods in Enzymology. 431: 47-60. PMID 17923230 DOI: 10.1016/S0076-6879(07)31004-5  0.768
2006 Yewdell JW, Nicchitta CV. The DRiP hypothesis decennial: support, controversy, refinement and extension. Trends in Immunology. 27: 368-73. PMID 16815756 DOI: 10.1016/J.It.2006.06.008  0.37
2006 Chu F, Maynard JC, Chiosis G, Nicchitta CV, Burlingame AL. Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. Protein Science : a Publication of the Protein Society. 15: 1260-9. PMID 16731965 DOI: 10.1110/Ps.052065106  0.702
2006 Lerner RS, Nicchitta CV. mRNA translation is compartmentalized to the endoplasmic reticulum following physiological inhibition of cap-dependent translation. Rna (New York, N.Y.). 12: 775-89. PMID 16540694 DOI: 10.1261/Rna.2318906  0.818
2005 Nicchitta CV, Lerner RS, Stephens SB, Dodd RD, Pyhtila B. Pathways for compartmentalizing protein synthesis in eukaryotic cells: the template-partitioning model. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 83: 687-95. PMID 16333319 DOI: 10.1139/O05-147  0.801
2005 Stephens SB, Dodd RD, Brewer JW, Lager PJ, Keene JD, Nicchitta CV. Stable ribosome binding to the endoplasmic reticulum enables compartment-specific regulation of mRNA translation. Molecular Biology of the Cell. 16: 5819-31. PMID 16221886 DOI: 10.1091/Mbc.E05-07-0685  0.827
2005 Parsa CJ, Reed RC, Walton GB, Pascal LS, Thompson RB, Petrofski JA, Emani SM, Folgar F, Riel RU, Nicchitta CV, Koch WJ. Catheter-mediated subselective intracoronary gene delivery to the rabbit heart: introduction of a novel method. The Journal of Gene Medicine. 7: 595-603. PMID 15651066 DOI: 10.1002/Jgm.704  0.466
2004 Nicchitta CV, Carrick DM, Baker-Lepain JC. The messenger and the message: gp96 (GRP94)-peptide interactions in cellular immunity. Cell Stress & Chaperones. 9: 325-31. PMID 15633290 DOI: 10.1379/Csc-62.1  0.797
2004 Rosser MF, Trotta BM, Marshall MR, Berwin B, Nicchitta CV. Adenosine nucleotides and the regulation of GRP94-client protein interactions. Biochemistry. 43: 8835-45. PMID 15236592 DOI: 10.1021/bi049539q  0.69
2004 Baker-LePain JC, Sarzotti M, Nicchitta CV. Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. Journal of Immunology (Baltimore, Md. : 1950). 172: 4195-203. PMID 15034032 DOI: 10.4049/Jimmunol.172.7.4195  0.793
2003 Berwin B, Hart JP, Rice S, Gass C, Pizzo SV, Post SR, Nicchitta CV. Scavenger receptor-A mediates gp96/GRP94 and calreticulin internalization by antigen-presenting cells. The Embo Journal. 22: 6127-36. PMID 14609958 DOI: 10.1093/Emboj/Cdg572  0.678
2003 Lerner RS, Seiser RM, Zheng T, Lager PJ, Reedy MC, Keene JD, Nicchitta CV. Partitioning and translation of mRNAs encoding soluble proteins on membrane-bound ribosomes. Rna (New York, N.Y.). 9: 1123-37. PMID 12923260 DOI: 10.1261/Rna.5610403  0.797
2003 Reed RC, Berwin B, Baker JP, Nicchitta CV. GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production. The Journal of Biological Chemistry. 278: 31853-60. PMID 12805368 DOI: 10.1074/Jbc.M305480200  0.731
2003 Baker-LePain JC, Reed RC, Nicchitta CV. ISO: a critical evaluation of the role of peptides in heat shock/chaperone protein-mediated tumor rejection. Current Opinion in Immunology. 15: 89-94. PMID 12495739 DOI: 10.1016/S0952791502000067  0.796
2002 Baker-LePain JC, Sarzotti M, Fields TA, Li CY, Nicchitta CV. GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. The Journal of Experimental Medicine. 196: 1447-59. PMID 12461080 DOI: 10.1084/Jem.20020436  0.777
2002 Nicchitta CV. A platform for compartmentalized protein synthesis: protein translation and translocation in the ER. Current Opinion in Cell Biology. 14: 412-6. PMID 12383790 DOI: 10.1016/S0955-0674(02)00353-8  0.38
2002 Reed RC, Zheng T, Nicchitta CV. GRP94-associated enzymatic activities. Resolution by chromatographic fractionation. The Journal of Biological Chemistry. 277: 25082-9. PMID 11983709 DOI: 10.1074/Jbc.M203195200  0.547
2002 Berwin B, Hart JP, Pizzo SV, Nicchitta CV. Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides. Journal of Immunology (Baltimore, Md. : 1950). 168: 4282-6. PMID 11970968 DOI: 10.4049/Jimmunol.168.9.4282  0.661
2002 Berwin B, Rosser MF, Brinker KG, Nicchitta CV. Transfer of GRP94(Gp96)-associated peptides onto endosomal MHC class I molecules. Traffic (Copenhagen, Denmark). 3: 358-66. PMID 11967129 DOI: 10.1034/j.1600-0854.2002.30505.x  0.657
2002 Potter MD, Nicchitta CV. Endoplasmic reticulum-bound ribosomes reside in stable association with the translocon following termination of protein synthesis. The Journal of Biological Chemistry. 277: 23314-20. PMID 11964406 DOI: 10.1074/Jbc.M202559200  0.741
2001 Berwin B, Nicchitta CV. To find the road traveled to tumor immunity: the trafficking itineraries of molecular chaperones in antigen-presenting cells. Traffic (Copenhagen, Denmark). 2: 690-7. PMID 11576445 DOI: 10.1034/j.1600-0854.2001.21003.x  0.682
2001 Potter MD, Seiser RM, Nicchitta CV. Ribosome exchange revisited: a mechanism for translation-coupled ribosome detachment from the ER membrane. Trends in Cell Biology. 11: 112-5. PMID 11306271 DOI: 10.1016/S0962-8924(00)01905-X  0.796
2001 Berwin B, Reed RC, Nicchitta CV. Virally induced lytic cell death elicits the release of immunogenic GRP94/gp96. The Journal of Biological Chemistry. 276: 21083-8. PMID 11279246 DOI: 10.1074/Jbc.M101836200  0.732
2000 Nicchitta CV, Reed RC. The immunological properties of endoplasmic reticulum chaperones: a conflict of interest? Essays in Biochemistry. 36: 15-25. PMID 12471899 DOI: 10.1042/Bse0360015  0.586
2000 Reed RC, Nicchitta CV. Chaperone-mediated cross-priming: a hitchhiker's guide to vesicle transport (review). International Journal of Molecular Medicine. 6: 259-64. PMID 10934286 DOI: 10.3892/Ijmm.6.3.259  0.631
2000 Seiser RM, Nicchitta CV. The fate of membrane-bound ribosomes following the termination of protein synthesis. The Journal of Biological Chemistry. 275: 33820-7. PMID 10931837 DOI: 10.1074/Jbc.M004462200  0.809
2000 Potter MD, Nicchitta CV. Regulation of ribosome detachment from the mammalian endoplasmic reticulum membrane. The Journal of Biological Chemistry. 275: 33828-35. PMID 10924518 DOI: 10.1074/Jbc.M005294200  0.726
2000 Wassenberg JJ, Reed RC, Nicchitta CV. Ligand interactions in the adenosine nucleotide-binding domain of the Hsp90 chaperone, GRP94. II. Ligand-mediated activation of GRP94 molecular chaperone and peptide binding activity. The Journal of Biological Chemistry. 275: 22806-14. PMID 10816560 DOI: 10.1074/Jbc.M001476200  0.534
2000 Potter MD, Nicchitta CV. Ribosome-independent regulation of translocon composition and Sec61alpha conformation. The Journal of Biological Chemistry. 275: 2037-45. PMID 10636907 DOI: 10.1074/Jbc.275.3.2037  0.685
1997 Nicchitta CV, Zheng T. Regulation of the ribosome-membrane junction at early stages of presecretory protein translocation in the mammalian endoplasmic reticulum. The Journal of Cell Biology. 139: 1697-708. PMID 9412465 DOI: 10.1083/jcb.139.7.1697  0.314
1996 Wearsch PA, Nicchitta CV. Purification and partial molecular characterization of GRP94, an ER resident chaperone. Protein Expression and Purification. 7: 114-21. PMID 9172775 DOI: 10.1006/prep.1996.0015  0.327
1993 Nicchitta CV, Blobel G. Lumenal proteins of the mammalian endoplasmic reticulum are required to complete protein translocation. Cell. 73: 989-98. PMID 8500184 DOI: 10.1016/0092-8674(93)90276-V  0.55
1993 Shelness GS, Lin L, Nicchitta CV. Membrane topology and biogenesis of eukaryotic signal peptidase. The Journal of Biological Chemistry. 268: 5201-8. PMID 8444896  0.329
1992 Migliaccio G, Nicchitta CV, Blobel G. The signal sequence receptor, unlike the signal recognition particle receptor, is not essential for protein translocation. The Journal of Cell Biology. 117: 15-25. PMID 1313437 DOI: 10.1083/Jcb.117.1.15  0.583
1991 Nicchitta C, Migliaccio G, Blobel G. Reconstitution of secretory protein translocation from detergent-solubilized rough microsomes. Methods in Cell Biology. 34: 263-85. PMID 1943804 DOI: 10.1016/B978-0-12-683755-1.50011-9  0.57
1991 Nicchitta CV, Migliaccio G, Blobel G. Biochemical fractionation and assembly of the membrane components that mediate nascent chain targeting and translocation. Cell. 65: 587-98. PMID 1851670 DOI: 10.1016/0092-8674(91)90091-C  0.513
1990 Watanabe M, Nicchitta CV, Blobel G. Reconstitution of protein translocation from detergent-solubilized Escherichia coli inverted vesicles: PrlA protein-deficient vesicles efficiently translocate precursor proteins. Proceedings of the National Academy of Sciences of the United States of America. 87: 1960-4. PMID 2408048  0.512
1990 Nicchitta CV, Blobel G. Assembly of translocation-competent proteoliposomes from detergent-solubilized rough microsomes. Cell. 60: 259-69. PMID 2297788 DOI: 10.1016/0092-8674(90)90741-V  0.493
1989 Nicchitta CV, Blobel G. Nascent secretory chain binding and translocation are distinct processes: differentiation by chemical alkylation. The Journal of Cell Biology. 108: 789-95. PMID 2537834  0.487
1987 Nicchitta CV, Joseph SK, Williamson JR. GTP-mediated Ca2+ release in rough endoplasmic reticulum. Correlation with a GTP-sensitive increase in membrane permeability. The Biochemical Journal. 248: 741-7. PMID 2829838 DOI: 10.1042/Bj2480741  0.408
1986 Nicchitta CV, Joseph SK, Williamson JR. Polyethylene glycol-stimulated microsomal GTP hydrolysis. Relationship to GTP-mediated Ca2+ release. Febs Letters. 209: 243-8. PMID 3025017 DOI: 10.1016/0014-5793(86)81120-6  0.415
1985 Nicchitta CV, Kamoun M, Williamson JR. Cyclosporine augments receptor-mediated cellular Ca2+ fluxes in isolated hepatocytes. The Journal of Biological Chemistry. 260: 13613-8. PMID 3877052  0.397
1984 Nicchitta CV, Williamson JR. Spermine. A regulator of mitochondrial calcium cycling. The Journal of Biological Chemistry. 259: 12978-83. PMID 6238031  0.36
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