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Kim Bottomly - Publications

Affiliations: 
1980-2007 Yale University, New Haven, CT 
 2007- President Wellesley College, Wellesley, MA, United States 
Area:
Cell Biology, Microbiology Biology, Molecular Biology
Website:
http://web.wellesley.edu/PublicAffairs/President/president.html
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Year Citation  Score
2014 Janeway CA, Bottomly K, Babich J, Conrad P, Conzen S, Jones B, Kaye J, Katz M, McVay L, Murphy DB, Tite J. Quantitative variation in la antigen expression plays a central role in immune regulation. Immunology Today. 5: 99-105. PMID 25291703 DOI: 10.1016/0167-5699(84)90043-4  0.527
2011 Dokmeci E, Xu L, Robinson E, Golubets K, Bottomly K, Herrick CA. EBI3 deficiency leads to diminished T helper type 1 and increased T helper type 2 mediated airway inflammation. Immunology. 132: 559-66. PMID 21255010 DOI: 10.1111/J.1365-2567.2010.03401.X  0.424
2010 Pochard P, Vickery B, Berin MC, Grishin A, Sampson HA, Caplan M, Bottomly K. Targeting Toll-like receptors on dendritic cells modifies the T(H)2 response to peanut allergens in vitro. The Journal of Allergy and Clinical Immunology. 126: 92-7.e5. PMID 20538332 DOI: 10.1016/J.Jaci.2010.04.003  0.544
2010 Albrecht M, Preston-Hurlburt P, Bottomly K, Dittrich A. Th17 Cells In The Lung Facilitate Priming Towards New Antigens Journal of Allergy and Clinical Immunology. 125: AB193. DOI: 10.1016/J.Jaci.2009.12.757  0.405
2009 Chapoval SP, Lee CG, Tang C, Keegan AD, Cohn L, Bottomly K, Elias JA. Lung vascular endothelial growth factor expression induces local myeloid dendritic cell activation. Clinical Immunology (Orlando, Fla.). 132: 371-84. PMID 19553159 DOI: 10.1016/J.Clim.2009.05.016  0.353
2009 Vickery B, Pochard P, Caplan M, Sampson H, Berin M, Bottomly K. Peanut Induced Dendritic Cell (DC) Maturation and Cytokine Production Is Modulated by the Microbial Components of EMP-123, Leading to Changes in Adaptive Immunity In Vitro Journal of Allergy and Clinical Immunology. 123: S211-S211. DOI: 10.1016/J.Jaci.2008.12.806  0.385
2008 Czyzyk J, Chen HC, Bottomly K, Flavell RA. p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells. The Journal of Biological Chemistry. 283: 23004-15. PMID 18577512 DOI: 10.1074/Jbc.M804084200  0.507
2008 DOKMECI E, XU L, BOTTOMLY K. EBI3 Deficient Cells Can Produce Comparable Levels of INF-g in the Presence of IL12 Journal of Allergy and Clinical Immunology. 121: S17-S17. DOI: 10.1016/J.Jaci.2007.12.069  0.378
2007 Holt JP, Bottomly K, Mooseker MS. Assessment of myosin II, Va, VI and VIIa loss of function on endocytosis and endocytic vesicle motility in bone marrow-derived dendritic cells. Cell Motility and the Cytoskeleton. 64: 756-66. PMID 17615572 DOI: 10.1002/Cm.20220  0.36
2007 Jackman RP, Balamuth F, Bottomly K. CTLA-4 differentially regulates the immunological synapse in CD4 T cell subsets. Journal of Immunology (Baltimore, Md. : 1950). 178: 5543-51. PMID 17442936 DOI: 10.4049/Jimmunol.178.9.5543  0.779
2007 Chen H, Piggott D, Xu L, Bottomly K. CD4+CD25+ T cells Regulate TLR4 Signaling in Pulmonary Dendritic Cells Journal of Allergy and Clinical Immunology. 119: S308. DOI: 10.1016/j.jaci.2006.12.576  0.408
2007 Dittrich A, Bottomly K. IL-4 Bypasses Innate Immune Signals in Inhalational Priming Journal of Allergy and Clinical Immunology. 119: S128. DOI: 10.1016/J.Jaci.2006.11.487  0.389
2007 Dokmeci E, Xu L, Blumberg R, Bottomly K. EBI3 Deficient Naive T cells Show Increase in Expression of Th2 Mediated Cytokines In-vitro Journal of Allergy and Clinical Immunology. 119: S45. DOI: 10.1016/J.Jaci.2006.11.197  0.562
2005 Piggott DA, Eisenbarth SC, Xu L, Constant SL, Huleatt JW, Herrick CA, Bottomly K. MyD88-dependent induction of allergic Th2 responses to intranasal antigen. The Journal of Clinical Investigation. 115: 459-67. PMID 15650773 DOI: 10.1172/Jci22462  0.717
2004 Eisenbarth SC, Cassel S, Bottomly K. Understanding asthma pathogenesis: linking innate and adaptive immunity. Current Opinion in Pediatrics. 16: 659-66. PMID 15548929 DOI: 10.1097/01.Mop.0000145920.00101.E4  0.388
2004 Meyer zum Bueschenfelde CO, Unternaehrer J, Mellman I, Bottomly K. Regulated recruitment of MHC class II and costimulatory molecules to lipid rafts in dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 6119-24. PMID 15528348 DOI: 10.4049/Jimmunol.173.10.6119  0.483
2004 Balamuth F, Brogdon JL, Bottomly K. CD4 raft association and signaling regulate molecular clustering at the immunological synapse site. Journal of Immunology (Baltimore, Md. : 1950). 172: 5887-92. PMID 15128768 DOI: 10.4049/Jimmunol.172.10.5887  0.396
2004 Eisenbarth SC, Zhadkevich A, Ranney P, Herrick CA, Bottomly K. IL-4-dependent Th2 collateral priming to inhaled antigens independent of Toll-like receptor 4 and myeloid differentiation factor 88. Journal of Immunology (Baltimore, Md. : 1950). 172: 4527-34. PMID 15034070 DOI: 10.4049/Jimmunol.172.7.4527  0.525
2003 Eisenbarth SC, Piggott DA, Bottomly K. The master regulators of allergic inflammation: dendritic cells in Th2 sensitization. Current Opinion in Immunology. 15: 620-6. PMID 14630194 DOI: 10.1016/J.Coi.2003.09.003  0.718
2003 Nikiforow S, Bottomly K, Miller G, Münz C. Cytolytic CD4(+)-T-cell clones reactive to EBNA1 inhibit Epstein-Barr virus-induced B-cell proliferation. Journal of Virology. 77: 12088-104. PMID 14581546 DOI: 10.1128/Jvi.77.22.12088-12104.2003  0.663
2003 Wisnewski AV, Herrick CA, Liu Q, Chen L, Bottomly K, Redlich CA. Human gamma/delta T-cell proliferation and IFN-gamma production induced by hexamethylene diisocyanate. The Journal of Allergy and Clinical Immunology. 112: 538-46. PMID 13679813 DOI: 10.1016/S0091-6749(03)01865-7  0.48
2003 Herrick CA, Bottomly K. To respond or not to respond: T cells in allergic asthma. Nature Reviews. Immunology. 3: 405-12. PMID 12766762 DOI: 10.1038/Nri1084  0.468
2003 Herrick CA, Das J, Xu L, Wisnewski AV, Redlich CA, Bottomly K. Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: genetic control of TH2-induced lung inflammation. The Journal of Allergy and Clinical Immunology. 111: 1087-94. PMID 12743574 DOI: 10.1067/Mai.2003.1413  0.428
2003 Czyzyk J, Brogdon JL, Badou A, Henegariu O, Preston Hurlburt P, Flavell R, Bottomly K. Activation of CD4 T cells by Raf-independent effectors of Ras. Proceedings of the National Academy of Sciences of the United States of America. 100: 6003-8. PMID 12721365 DOI: 10.1073/Pnas.1031494100  0.454
2003 Das G, Augustine MM, Das J, Bottomly K, Ray P, Ray A. An important regulatory role for CD4+CD8 alpha alpha T cells in the intestinal epithelial layer in the prevention of inflammatory bowel disease. Proceedings of the National Academy of Sciences of the United States of America. 100: 5324-9. PMID 12695566 DOI: 10.1073/Pnas.0831037100  0.498
2003 Huleatt JW, Cresswell J, Bottomly K, Crispe IN. P27kip1 regulates the cell cycle arrest and survival of activated T lymphocytes in response to interleukin-2 withdrawal. Immunology. 108: 493-501. PMID 12667211 DOI: 10.1046/J.1365-2567.2003.01605.X  0.569
2003 Blander JM, Sant'Angelo DB, Metz D, Kim SW, Flavell RA, Bottomly K, Janeway CA. A pool of central memory-like CD4 T cells contains effector memory precursors. Journal of Immunology (Baltimore, Md. : 1950). 170: 2940-8. PMID 12626545 DOI: 10.4049/Jimmunol.170.6.2940  0.636
2003 Herrick CA, Xu L, McKenzie AN, Tigelaar RE, Bottomly K. IL-13 is necessary, not simply sufficient, for epicutaneously induced Th2 responses to soluble protein antigen. Journal of Immunology (Baltimore, Md. : 1950). 170: 2488-95. PMID 12594274 DOI: 10.4049/Jimmunol.170.5.2488  0.419
2003 Jorritsma PJ, Brogdon JL, Bottomly K. Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 170: 2427-34. PMID 12594266 DOI: 10.4049/Jimmunol.170.5.2427  0.762
2002 Eisenbarth SC, Piggott DA, Huleatt JW, Visintin I, Herrick CA, Bottomly K. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. The Journal of Experimental Medicine. 196: 1645-51. PMID 12486107 DOI: 10.1084/Jem.20021340  0.73
2002 Constant SL, Brogdon JL, Piggott DA, Herrick CA, Visintin I, Ruddle NH, Bottomly K. Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ. The Journal of Clinical Investigation. 110: 1441-8. PMID 12438442 DOI: 10.1172/Jci16109  0.775
2002 Holcombe H, Mellman I, Janeway CA, Bottomly K, Dittel BN. The immunosuppressive agent 15-deoxyspergualin functions by inhibiting cell cycle progression and cytokine production following naive T cell activation. Journal of Immunology (Baltimore, Md. : 1950). 169: 4982-9. PMID 12391212 DOI: 10.4049/Jimmunol.169.9.4982  0.683
2002 Brogdon JL, Leitenberg D, Bottomly K. The potency of TCR signaling differentially regulates NFATc/p activity and early IL-4 transcription in naive CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 168: 3825-32. PMID 11937535 DOI: 10.4049/Jimmunol.168.8.3825  0.537
2002 He X, Janeway CA, Levine M, Robinson E, Preston-Hurlburt P, Viret C, Bottomly K. Dual receptor T cells extend the immune repertoire for foreign antigens. Nature Immunology. 3: 127-34. PMID 11812989 DOI: 10.1038/Ni751  0.671
2002 Eisenbarth S, Herrick C, Bottomly K. Th2 priming induced by intranasal exposure to soluble protein antigens Journal of Allergy and Clinical Immunology. 109: S263-S263. DOI: 10.1016/S0091-6749(02)81937-6  0.365
2001 Davis LS, Lipsky PE, Bottomly K. Measurement of human and murine interleukin 2 and interleukin 4. Current Protocols in Immunology / Edited by John E. Coligan ... [Et Al.]. Unit 6.3. PMID 18432816 DOI: 10.1002/0471142735.Im0603S37  0.376
2001 Balamuth F, Leitenberg D, Unternaehrer J, Mellman I, Bottomly K. Distinct patterns of membrane microdomain partitioning in Th1 and th2 cells. Immunity. 15: 729-38. PMID 11728335 DOI: 10.1016/S1074-7613(01)00223-0  0.519
2001 Leitenberg D, Balamuth F, Bottomly K. Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation Seminars in Immunology. 13: 129-138. PMID 11308296 DOI: 10.1006/Smim.2000.0304  0.479
2001 Nikiforow S, Bottomly K, Miller G. CD4+ T-cell effectors inhibit Epstein-Barr virus-induced B-cell proliferation. Journal of Virology. 75: 3740-52. PMID 11264363 DOI: 10.1128/Jvi.75.8.3740-3752.2001  0.65
2001 Cohn L, Herrick C, Niu N, Homer R, Bottomly K. IL-4 promotes airway eosinophilia by suppressing IFN-gamma production: defining a novel role for IFN-gamma in the regulation of allergic airway inflammation. Journal of Immunology (Baltimore, Md. : 1950). 166: 2760-7. PMID 11160342 DOI: 10.4049/Jimmunol.166.4.2760  0.444
2000 Czyzyk J, Leitenberg D, Taylor T, Bottomly K. Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTpases Ras and Rap1 Molecular and Cellular Biology. 20: 8740-8747. PMID 11073975 DOI: 10.1128/Mcb.20.23.8740-8747.2000  0.474
2000 Blander JM, Sant'Angelo DB, Bottomly K, Janeway CA. Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2. The Journal of Experimental Medicine. 191: 2065-74. PMID 10859331 DOI: 10.1084/Jem.191.12.2065  0.657
2000 Constant SL, Lee KS, Bottomly K. Site of antigen delivery can influence T cell priming: Pulmonary environment promotes preferential Th2-type differentiation European Journal of Immunology. 30: 840-847. PMID 10741400 DOI: 10.1002/1521-4141(200003)30:3<840::Aid-Immu840>3.0.Co;2-L  0.516
2000 Herrick CA, MacLeod H, Glusac E, Tigelaar RE, Bottomly K. Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. The Journal of Clinical Investigation. 105: 765-75. PMID 10727445 DOI: 10.1172/Jci8624  0.419
2000 Bottomly K, Cresswell P, Flavell RA, Janeway CA, Pober JS. Continuity and Change Immunity. 12: 119. DOI: 10.1016/S1074-7613(00)80164-8  0.409
1999 Welte T, Leitenberg D, Dittel BN, al-Ramadi BK, Hansen WR, Xie B, Janeway CA, Bothwell AL, Bottomly K, Fu XY. The PTK-STAT signaling pathway has essential roles in T-cell activation in response to antigen stimulation. Cold Spring Harbor Symposia On Quantitative Biology. 64: 291-302. PMID 11232299 DOI: 10.1101/sqb.1999.64.291  0.577
1999 Cohn L, Homer RJ, Niu N, Bottomly K. T helper 1 cells and interferon γ regulate allergic airway inflammation and mucus production Journal of Experimental Medicine. 190: 1309-1317. PMID 10544202 DOI: 10.1084/Jem.190.9.1309  0.515
1999 Metz DP, Bottomly K. Function and regulation of memory CD4 T cells. Immunologic Research. 19: 127-41. PMID 10493168 DOI: 10.1007/Bf02786482  0.55
1999 Leitenberg D, Bottomly K. Regulation of naive T cell differentiation by varying the potency of TCR signal transduction Seminars in Immunology. 11: 283-292. PMID 10441214 DOI: 10.1006/Smim.1999.0184  0.535
1999 Leitenberg D, Boutin Y, Lu DD, Bottomly K. Biochemical association of CD45 with the T cell receptor complex: Regulation by CD45 isoform and during T cell activation Immunity. 10: 701-711. PMID 10403645 DOI: 10.1016/S1074-7613(00)80069-2  0.511
1999 Bottomly K. T cells and dendritic cells get intimate. Science (New York, N.Y.). 283: 1124-5. PMID 10075571 DOI: 10.1126/Science.283.5405.1124  0.556
1999 Welte T, Leitenberg D, Dittel BN, al-Ramadi BK, Xie B, Chin YE, Janeway CA, Bothwell AL, Bottomly K, Fu XY. STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation. Science (New York, N.Y.). 283: 222-5. PMID 9880255 DOI: 10.1126/Science.283.5399.222  0.654
1998 Herrick CA, Tigelaar RE, Bottomly K. Regulation of epicutaneously induced TH2 responses to soluble protein by interleukin-4 Journal of Dermatological Science. 16: S4. DOI: 10.1016/S0923-1811(98)83022-3  0.376
1997 Cohn L, Homer RJ, Marinov A, Rankin J, Bottomly K. Induction of airway mucus production By T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. The Journal of Experimental Medicine. 186: 1737-47. PMID 9362533 DOI: 10.1084/Jem.186.10.1737  0.527
1997 Farber DL, Acuto O, Bottomly K. Differential T cell receptor-mediated signaling in naive and memory CD4 T cells. European Journal of Immunology. 27: 2094-101. PMID 9295050 DOI: 10.1002/Eji.1830270838  0.512
1997 Zhang DH, Cohn L, Ray P, Bottomly K, Ray A. Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. The Journal of Biological Chemistry. 272: 21597-603. PMID 9261181 DOI: 10.1074/Jbc.272.34.21597  0.576
1997 Constant SL, Bottomly K. Induction of TH1 and TH2 CD4+ T cell responses: The alternative approaches Annual Review of Immunology. 15: 297-322. PMID 9143690 DOI: 10.1146/Annurev.Immunol.15.1.297  0.588
1996 Janeway CA, Bottomly K. Responses of T cells to ligands for the T-cell receptor Seminars in Immunology. 8: 109-115. PMID 8920245 DOI: 10.1006/Smim.1996.0013  0.652
1996 Leitenberg D, Novak TJ, Farber D, Smith BR, Bottomly K. The extracellular domain of CD45 controls association with the CD4-T cell receptor complex and the response to antigen-specific stimulation Journal of Experimental Medicine. 183: 249-259. PMID 8551228 DOI: 10.1084/Jem.183.1.249  0.481
1995 Pfeiffer C, Stein J, Southwood S, Ketelaar H, Sette A, Bottomly K. Altered peptide ligands can control CD4 T lymphocyte differentiation in vivo. The Journal of Experimental Medicine. 181: 1569-74. PMID 7699337 DOI: 10.1084/Jem.181.4.1569  0.603
1995 Constant S, Pfeiffer C, Woodard A, Pasqualini T, Bottomly K. Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells. The Journal of Experimental Medicine. 182: 1591-6. PMID 7595230 DOI: 10.1084/Jem.182.5.1591  0.606
1995 Leitenberg D, Constant S, Lu DD, Smith BR, Bottomly K. CD4 and CD45 regulate qualitatively distinct patterns of calcium mobilization in individual CD4+ T cells European Journal of Immunology. 25: 2445-2451. PMID 7589109 DOI: 10.1002/Eji.1830250906  0.448
1995 Farber DL, Luqman M, Acuto O, Bottomly K. Control of memory CD4 T cell activation: MHC class II molecules on APCs and CD4 ligation inhibit memory but not naive CD4 T cells. Immunity. 2: 249-59. PMID 7535181 DOI: 10.1016/1074-7613(95)90049-7  0.524
1994 Constant S, Zain M, West J, Pasqualini T, Ranney P, Bottomly K. Are primed CD4+ T lymphocytes different from unprimed cells? European Journal of Immunology. 24: 1073-9. PMID 7910137 DOI: 10.1002/Eji.1830240510  0.581
1994 Janeway CA, Bottomly K. Signals and signs for lymphocyte responses Cell. 76: 275-285. PMID 7904901 DOI: 10.1016/0092-8674(94)90335-2  0.696
1994 Kamogawa Y, Minasi LA, Carding SR, Bottomly K, Flavell RA. The relationship of IL-4- and IFN gamma-producing T cells studied by lineage ablation of IL-4-producing cells. Cell. 75: 985-95. PMID 7902780 DOI: 10.1016/0092-8674(93)90542-X  0.461
1994 Novak TJ, Farber D, Leitenberg D, Hong Sc, Johnson P, Bottomly K. Isoforms of the transmembrane tyrosine phosphatase cd45 differentially affect T cell recognition Immunity. 1: 109-119. PMID 7889403 DOI: 10.1016/1074-7613(94)90104-X  0.556
1994 Yoon ST, Dianzani U, Bottomly K, Janeway CA. Both high and low avidity antibodies to the T cell receptor can have agonist or antagonist activity Immunity. 1: 563-569. PMID 7600285 DOI: 10.1016/1074-7613(94)90046-9  0.575
1993 Minasi LE, Kamogawa Y, Carding S, Bottomly K, Flavell RA. The selective ablation of interleukin 2-producing cells isolated from transgenic mice. The Journal of Experimental Medicine. 177: 1451-9. PMID 8386745 DOI: 10.1084/Jem.177.5.1451  0.729
1992 Pfeiffer C, Murray J, Madri J, Bottomly K. Selective activation of Th1- and Th2-like cells in vivo--response to human collagen IV. Immunological Reviews. 123: 65-84. PMID 1684784 DOI: 10.1111/J.1600-065X.1991.Tb00606.X  0.561
1992 Carding SR, Lu D, Bottomly K. A polymerase chain reaction assay for the detection and quantitation of cytokine gene expression in small numbers of cells. Journal of Immunological Methods. 151: 277-87. PMID 1629616 DOI: 10.1016/0022-1759(92)90128-G  0.416
1992 Dianzani U, Redoglia V, Malavasi F, Bragardo M, Pileri A, Janeway CA, Bottomly K. Isoform-specific associations of CD45 with accessory molecules in human T lymphocytes European Journal of Immunology. 22: 365-371. PMID 1531636 DOI: 10.1002/Eji.1830220212  0.605
1992 Dobber R, Hertogh-Huijbregts A, Rozing J, Bottomly K, Nagelkerken L. The involvement of the intestinal microflora in the expansion of CD4+ T cells with a naive phenotype in the periphery. Developmental Immunology. 2: 141-50. PMID 1386544 DOI: 10.1155/1992/57057  0.466
1992 Murray JS, Pfeiffer C, Madri J, Bottomly K. Major histocompatibility complex (MHC) control of CD4 T cell subset activation. II. A single peptide induces either humoral or cell-mediated responses in mice of distinct MHC genotype European Journal of Immunology. 22: 559-565. PMID 1347015 DOI: 10.1002/Eji.1830220239  0.476
1992 Luqman M, Greenbaum L, Lu D, Bottomly K. Differential effect of interleukin 1 on naive and memory CD4+ T cells. European Journal of Immunology. 22: 95-100. PMID 1346115 DOI: 10.1002/Eji.1830220115  0.558
1991 Carding SR, Hayday AC, Bottomly K. Cytokines in T-cell development. Immunology Today. 12: 239-45. PMID 1888430 DOI: 10.1016/0167-5699(91)90037-T  0.525
1991 McVay LD, Hayday AC, Bottomly K, Carding SR. Thymic and extrathymic development of human gamma/delta T cells. Current Topics in Microbiology and Immunology. 173: 57-63. PMID 1833160 DOI: 10.1007/978-3-642-76492-9_9  0.394
1991 Hobbs MV, Ernst DN, Torbett BE, Glasebrook AL, Rehse MA, McQuitty DN, Thoman ML, Bottomly K, Rothermel AL, Noonan DJ, Weigle WO. Cell proliferation and cytokine production by CD4+ cells from old mice Journal of Cellular Biochemistry. 46: 312-320. PMID 1684583 DOI: 10.1002/Jcb.240460406  0.485
1991 Luqman M, Johnson P, Trowbridge I, Bottomly K. Differential expression of the alternatively spliced exons of murine CD45 in Th1 and Th2 cell clones. European Journal of Immunology. 21: 17-22. PMID 1671357 DOI: 10.1002/Eji.1830210104  0.537
1991 McVay LD, Carding SR, Bottomly K, Hayday AC. Regulated expression and structure of T cell receptor gamma/delta transcripts in human thymic ontogeny. The Embo Journal. 10: 83-91. DOI: 10.1002/J.1460-2075.1991.Tb07923.X  0.402
1990 Killar LM, Hatfield CA, Carding SR, Pan M, Winterrowd GE, Bottomly K. In vivo administration of interleukin 1 elicits increased Ia antigen expression on B cells through the induction of interleukin 4. European Journal of Immunology. 19: 2205-10. PMID 2575031 DOI: 10.1002/Eji.1830191205  0.413
1990 Murray JS, Madri J, Tite J, Carding SR, Bottomly K. MHC control of CD4+ T cell subset activation. The Journal of Experimental Medicine. 170: 2135-40. PMID 2573684 DOI: 10.1084/Jem.170.6.2135  0.603
1990 Polan ML, Kuo A, Loukides J, Bottomly K. Cultured human luteal peripheral monocytes secrete increased levels of interleukin-1. The Journal of Clinical Endocrinology and Metabolism. 70: 480-4. PMID 2298860 DOI: 10.1210/Jcem-70-2-480  0.348
1990 Carding SR, Kyes S, Jenkinson EJ, Kingston R, Bottomly K, Owen JJ, Hayday AC. Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression. Genes & Development. 4: 1304-15. PMID 2227410 DOI: 10.1101/Gad.4.8.1304  0.394
1990 Carding SR, Allan W, Kyes S, Hayday A, Bottomly K, Doherty PC. Late dominance of the inflammatory process in murine influenza by gamma/delta + T cells. The Journal of Experimental Medicine. 172: 1225-31. PMID 2145388 DOI: 10.1084/Jem.172.4.1225  0.446
1990 Carding SR, McNamara JG, Pan M, Bottomly K. Characterization of gamma/delta T cell clones isolated from human fetal liver and thymus. European Journal of Immunology. 20: 1327-35. PMID 2142459 DOI: 10.1002/Eji.1830200619  0.548
1989 Bottomly K. A functional dichotomy in CD4+ T lymphocytes. Immunology Today. 9: 268-74. PMID 2908229 DOI: 10.1016/0167-5699(88)91308-4  0.58
1989 Carding SR, West J, Woods A, Bottomly K. Differential activation of cytokine genes in normal CD4-bearing T cells is stimulus dependent. European Journal of Immunology. 19: 231-8. PMID 2784764 DOI: 10.1002/Eji.1830190203  0.503
1989 Polan ML, Loukides J, Nelson P, Carding S, Diamond M, Walsh A, Bottomly K. Progesterone and estradiol modulate interleukin-1 beta messenger ribonucleic acid levels in cultured human peripheral monocytes. The Journal of Clinical Endocrinology and Metabolism. 69: 1200-6. PMID 2584355 DOI: 10.1210/Jcem-69-6-1200  0.605
1989 Bottomly K, Luqman M, Greenbaum L, Carding S, West J, Pasqualini T, Murphy DB. A monoclonal antibody to murine CD45R distinguishes CD4 T cell populations that produce different cytokines. European Journal of Immunology. 19: 617-23. PMID 2567241 DOI: 10.1002/Eji.1830190407  0.737
1989 Bottomly K, Janeway CA. Antigen presentation by B cells. Nature. 337: 24. PMID 2562905 DOI: 10.1038/337024A0  0.378
1989 Carding SR, Jenkinson EJ, Kingston R, Hayday AC, Bottomly K, Owen JJ. Developmental control of lymphokine gene expression in fetal thymocytes during T-cell ontogeny. Proceedings of the National Academy of Sciences of the United States of America. 86: 3342-5. PMID 2497464 DOI: 10.1073/Pnas.86.9.3342  0.388
1989 Johnson P, Greenbaum L, Bottomly K, Trowbridge IS. Identification of the alternatively spliced exons of murine CD45 (T200) required for reactivity with B220 and other T200-restricted antibodies. The Journal of Experimental Medicine. 169: 1179-84. PMID 2466938 DOI: 10.1084/Jem.169.3.1179  0.327
1988 Janeway CA, Carding S, Jones B, Murray J, Portoles P, Rasmussen R, Rojo J, Saizawa K, West J, Bottomly K. CD4+ T cells: specificity and function. Immunological Reviews. 101: 39-80. PMID 2450827 DOI: 10.1111/J.1600-065X.1988.Tb00732.X  0.75
1985 Kim J, Woods A, Becker-Dunn E, Bottomly K. Distinct functional phenotypes of cloned Ia-restricted helper T cells. The Journal of Experimental Medicine. 162: 188-201. PMID 3159823 DOI: 10.1084/Jem.162.1.188  0.502
1985 Becker Dunn E, Bottomly K. T15-specific helper T cells: analysis of idiotype specificity by competitive inhibition analysis. European Journal of Immunology. 15: 728-32. PMID 2408904 DOI: 10.1002/Eji.1830150717  0.511
1984 Bottomly K. 1984: all idiotypes are equal, but some are more equal than others. Immunological Reviews. 79: 45-61. PMID 6235171 DOI: 10.1111/J.1600-065X.1984.Tb00486.X  0.425
1984 Bottomly K, Dunn E. The role of B-cell I region encoded antigens in T-cell dependent B-cell activation: I region encoded antigen density correlates with idiotype expression. Annals of the New York Academy of Sciences. 418: 230-9. PMID 6231878 DOI: 10.1111/J.1749-6632.1983.Tb18070.X  0.45
1983 Janeway CA, Bottomly K, Jones B, Jones PP, Lerner EA, Matis LA, McNicholas JM, Murphy DB, Schwartz RH. Helper T cells specific for protein antigens: role of self major histocompatibility complex and immunoglobulin gene products. Advances in Experimental Medicine and Biology. 150: 53-71. PMID 6293285 DOI: 10.1007/978-1-4684-4331-8_4  0.544
1983 Bottomly K, Jones B, Kaye J, Jones F. Subpopulations of B cells distinguished by cell surface expression of Ia antigens. Correlation of Ia and idiotype during activation by cloned Ia-restricted T cells. The Journal of Experimental Medicine. 158: 265-79. PMID 6193216 DOI: 10.1084/Jem.158.2.265  0.527
1981 Bottomly K, Mosier DE. Antigen-specific helper T cells required for dominant idiotype expression are not H-2 restricted. The Journal of Experimental Medicine. 154: 411-21. PMID 6973603 DOI: 10.1084/Jem.154.2.411  0.544
1981 Bottomly K, Janeway CA. Selected populations of alloreactive T cells contain helper T cells but lack ThId, an antigen-specific helper T cell required for dominant production of the T15 idiotype. European Journal of Immunology. 11: 270-4. PMID 6972311 DOI: 10.1002/Eji.1830110319  0.649
1981 Bottomly K, Maurer PH. Antigen-specific helper T cells required for dominant production of an idiotype (THId) are not under immune response (Ir) gene control. The Journal of Experimental Medicine. 152: 1571-82. PMID 6161200 DOI: 10.1084/Jem.152.6.1571  0.528
1980 Bottomly K, Janeway CA, Mathieson BJ, Mosier DE. Absence of an antigen-specific helper T cell required for the expression of the T 15 idiotype in mice treated with anti-mu antibody. European Journal of Immunology. 10: 159-63. PMID 6154584 DOI: 10.1002/Eji.1830100217  0.642
1980 Bottomly K, Mosier DE. Mice whose B cells cannot produce the T15 idiotype also lack an antigen-specific helper T cell required for T15 expression. The Journal of Experimental Medicine. 150: 1399-409. PMID 92522 DOI: 10.1084/Jem.150.6.1399  0.443
1978 Bottomly K, Mathieson BJ, Mosier DE. Anti-idiotype induced regulation of helper cell function for the response to phosphorylcholine in adult BALB/c mice. The Journal of Experimental Medicine. 148: 1216-27. PMID 309912 DOI: 10.1084/Jem.148.5.1216  0.512
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