Randall W. King - Publications

Cell Biology Harvard Medical School, Boston, MA, United States 
Mitosis, cell cycle

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Rossio V, Paulo JA, Chick J, Brasher B, Gygi SP, King RW. Proteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity. Cell Chemical Biology. PMID 33417828 DOI: 10.1016/j.chembiol.2020.12.007  0.32
2020 Manohar S, Yu Q, Gygi SP, King RW. The insulin receptor adaptor IRS2 is an APC/C substrate that promotes cell cycle protein expression and a robust spindle assembly checkpoint. Molecular & Cellular Proteomics : McP. PMID 32554797 DOI: 10.1074/Mcp.Ra120.002069  0.32
2020 Richeson KV, Bodrug T, Sackton KL, Yamaguchi M, Paulo JA, Gygi SP, Schulman BA, Brown NG, King RW. Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C. Nature Chemical Biology. PMID 32152539 DOI: 10.1038/S41589-020-0495-Z  0.32
2020 Dukovski D, Villella A, Bastos C, King R, Finley D, Kelly JW, Morimoto RI, Hartl FU, Munoz B, Lee PS, Zecevic M, Miller JP. Amplifiers co-translationally enhance CFTR biosynthesis via PCBP1-mediated regulation of CFTR mRNA. Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. PMID 32067958 DOI: 10.1016/J.Jcf.2020.02.006  0.32
2017 Boselli M, Lee BH, Robert J, Prado MA, Min SW, Cheng C, Silva MC, Seong C, Elsasser S, Hatle KM, Gahman TC, Gygi SP, Haggarty SJ, Gan L, King RW, et al. An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons. The Journal of Biological Chemistry. PMID 28972160 DOI: 10.1074/Jbc.M117.815126  0.4
2016 Lee BH, Lu Y, Prado MA, Shi Y, Tian G, Sun S, Elsasser S, Gygi SP, King RW, Finley D. USP14 deubiquitinates proteasome-bound substrates that are ubiquitinated at multiple sites. Nature. PMID 27074503 DOI: 10.1038/Nature17433  1
2015 Lub S, Maes A, Maes K, De Veirman K, De Bruyne E, Menu E, Fostier K, Kassambara A, Moreaux J, Hose D, Leleu X, King RW, Vanderkerken K, Van Valckenborgh E. Inhibiting the anaphase promoting complex/cyclosome induces a metaphase arrest and cell death in multiple myeloma cells. Oncotarget. PMID 26716651 DOI: 10.18632/Oncotarget.6768  1
2015 Lu Y, Lee BH, King RW, Finley D, Kirschner MW. Substrate degradation by the proteasome: a single-molecule kinetic analysis. Science (New York, N.Y.). 348: 1250834. PMID 25859050 DOI: 10.1126/Science.1250834  1
2014 King RW, Finley D. Sculpting the proteome with small molecules. Nature Chemical Biology. 10: 870-4. PMID 25325686 DOI: 10.1038/Nchembio.1671  1
2014 Sackton KL, Dimova N, Zeng X, Tian W, Zhang M, Sackton TB, Meaders J, Pfaff KL, Sigoillot F, Yu H, Luo X, King RW. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature. 514: 646-9. PMID 25156254 DOI: 10.1038/Nature13660  1
2013 Lim HJ, Dimova NV, Tan MK, Sigoillot FD, King RW, Shi Y. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. Molecular and Cellular Biology. 33: 4166-80. PMID 23979597 DOI: 10.1128/Mcb.00689-13  1
2013 Pfaff KL, King RW. Determinants of human cyclin B1 association with mitotic chromosomes. Plos One. 8: e59169. PMID 23505570 DOI: 10.1371/Journal.Pone.0059169  1
2012 Zeng X, King RW. An APC/C inhibitor stabilizes cyclin B1 by prematurely terminating ubiquitination. Nature Chemical Biology. 8: 383-92. PMID 22366722 DOI: 10.1038/Nchembio.801  1
2012 Adamson B, Smogorzewska A, Sigoillot FD, King RW, Elledge SJ. A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nature Cell Biology. 14: 318-28. PMID 22344029 DOI: 10.1038/Ncb2426  1
2012 Sigoillot FD, Lyman S, Huckins JF, Adamson B, Chung E, Quattrochi B, King RW. A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens. Nature Methods. 9: 363-6. PMID 22343343 DOI: 10.1038/Nmeth.1898  1
2012 Dimova NV, Hathaway NA, Lee BH, Kirkpatrick DS, Berkowitz ML, Gygi SP, Finley D, King RW. APC/C-mediated multiple monoubiquitylation provides an alternative degradation signal for cyclin B1. Nature Cell Biology. 14: 168-76. PMID 22286100 DOI: 10.1038/Ncb2425  1
2011 Sigoillot FD, Huckins JF, Li F, Zhou X, Wong ST, King RW. A time-series method for automated measurement of changes in mitotic and interphase duration from time-lapse movies. Plos One. 6: e25511. PMID 21966537 DOI: 10.1371/Journal.Pone.0025511  1
2011 Miduturu CV, Deng X, Kwiatkowski N, Yang W, Brault L, Filippakopoulos P, Chung E, Yang Q, Schwaller J, Knapp S, King RW, Lee JD, Herrgard S, Zarrinkar P, Gray NS. High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors. Chemistry & Biology. 18: 868-79. PMID 21802008 DOI: 10.1016/J.Chembiol.2011.05.010  1
2011 Harper JW, King RW. Stuck in the middle: drugging the ubiquitin system at the e2 step. Cell. 145: 1007-9. PMID 21703444 DOI: 10.1016/J.Cell.2011.06.002  1
2011 Krajcovic M, Johnson NB, Sun Q, Normand G, Hoover N, Yao E, Richardson AL, King RW, Cibas ES, Schnitt SJ, Brugge JS, Overholtzer M. A non-genetic route to aneuploidy in human cancers. Nature Cell Biology. 13: 324-30. PMID 21336303 DOI: 10.1038/Ncb2174  1
2011 Sigoillot FD, King RW. Vigilance and validation: Keys to success in RNAi screening. Acs Chemical Biology. 6: 47-60. PMID 21142076 DOI: 10.1021/Cb100358F  1
2011 Lee MJ, Lee BH, Hanna J, King RW, Finley D. Trimming of ubiquitin chains by proteasome-associated deubiquitinating enzymes. Molecular & Cellular Proteomics : McP. 10: R110.003871. PMID 20823120 DOI: 10.1074/Mcp.R110.003871  1
2010 Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 18: 382-95. PMID 20951947 DOI: 10.1016/J.Ccr.2010.08.010  1
2010 Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC, Gartner C, Dimova N, Hanna J, Gygi SP, Wilson SM, King RW, Finley D. Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature. 467: 179-84. PMID 20829789 DOI: 10.1038/Nature09299  1
2010 Normand G, King RW. Understanding cytokinesis failure. Advances in Experimental Medicine and Biology. 676: 27-55. PMID 20687468 DOI: 10.1007/978-1-4419-6199-0_3  1
2008 King RW. When 2+2=5: the origins and fates of aneuploid and tetraploid cells. Biochimica Et Biophysica Acta. 1786: 4-14. PMID 18703117 DOI: 10.1016/J.Bbcan.2008.07.007  1
2008 Wang M, Zhou X, Li F, Huckins J, King RW, Wong ST. Novel cell segmentation and online SVM for cell cycle phase identification in automated microscopy. Bioinformatics (Oxford, England). 24: 94-101. PMID 17989093 DOI: 10.1093/Bioinformatics/Btm530  1
2008 Liang L, Zhou X, Li F, Wong STC, Huckins J, King RW. Mitosis cell identification with conditional random fields 2007 Ieee/Nih Life Science Systems and Applications Workshop, Lisa. 9-12. DOI: 10.1109/LSSA.2007.4400872  1
2007 Overholtzer M, Mailleux AA, Mouneimne G, Normand G, Schnitt SJ, King RW, Cibas ES, Brugge JS. A nonapoptotic cell death process, entosis, that occurs by cell-in-cell invasion. Cell. 131: 966-79. PMID 18045538 DOI: 10.1016/J.Cell.2007.10.040  1
2007 Kleijnen MF, Roelofs J, Park S, Hathaway NA, Glickman M, King RW, Finley D. Stability of the proteasome can be regulated allosterically through engagement of its proteolytic active sites. Nature Structural & Molecular Biology. 14: 1180-8. PMID 18026118 DOI: 10.1038/Nsmb1335  1
2007 Bentley AM, Normand G, Hoyt J, King RW. Distinct sequence elements of cyclin B1 promote localization to chromatin, centrosomes, and kinetochores during mitosis. Molecular Biology of the Cell. 18: 4847-58. PMID 17881737 DOI: 10.1091/Mbc.E06-06-0539  1
2007 Wang M, Zhou X, King RW, Wong ST. Context based mixture model for cell phase identification in automated fluorescence microscopy. Bmc Bioinformatics. 8: 32. PMID 17263881 DOI: 10.1186/1471-2105-8-32  1
2007 Wang M, Zhou X, Li F, Huckins J, King RW, Wong STC. Novel cell segmentation and online learning algorithms for cell phase identification in automated time-lapse microscopy 2007 4th Ieee International Symposium On Biomedical Imaging: From Nano to Macro - Proceedings. 65-68. DOI: 10.1109/ISBI.2007.356789  1
2006 Crosas B, Hanna J, Kirkpatrick DS, Zhang DP, Tone Y, Hathaway NA, Buecker C, Leggett DS, Schmidt M, King RW, Gygi SP, Finley D. Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities. Cell. 127: 1401-13. PMID 17190603 DOI: 10.1016/J.Cell.2006.09.051  1
2006 Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, Finley D. Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell. 127: 99-111. PMID 17018280 DOI: 10.1016/J.Cell.2006.07.038  1
2006 Kirkpatrick DS, Hathaway NA, Hanna J, Elsasser S, Rush J, Finley D, King RW, Gygi SP. Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nature Cell Biology. 8: 700-10. PMID 16799550 DOI: 10.1038/Ncb1436  1
2006 Bentley M, King R. Long-term imaging mammalian cells using wide-field microscopy Journal of Visualized Experiments. DOI: 10.3791/120  1
2006 Shi Q, King RW. Cell biology: Shi & King reply Nature. 442: E10. DOI: 10.1038/Nature05140  1
2005 Stern HM, Murphey RD, Shepard JL, Amatruda JF, Straub CT, Pfaff KL, Weber G, Tallarico JA, King RW, Zon LI. Small molecules that delay S phase suppress a zebrafish bmyb mutant. Nature Chemical Biology. 1: 366-70. PMID 16372403 DOI: 10.1038/Nchembio749  1
2005 Hoyt J, King RW. Adenoviral expression of reporter proteins for high-throughput cell-based screening. Methods in Molecular Biology (Clifton, N.J.). 310: 187-95. PMID 16353377 DOI: 10.1007/978-1-59259-948-6_13  1
2005 Salic A, King RW. Identifying small molecule inhibitors of the ubiquitin-proteasome pathway in Xenopus egg extracts. Methods in Enzymology. 399: 567-85. PMID 16338382 DOI: 10.1016/S0076-6879(05)99038-1  1
2005 Shi Q, King RW. Chromosome nondisjunction yields tetraploid rather than aneuploid cells in human cell lines. Nature. 437: 1038-42. PMID 16222248 DOI: 10.1038/Nature03958  1
2005 Lorang J, King RW. Cytological profiling: providing more haystacks for chemists' needles. Genome Biology. 6: 228. PMID 16086858 DOI: 10.1186/Gb-2005-6-8-228  1
2005 Hathaway NA, King RW. Dissecting cell biology with chemical scalpels. Current Opinion in Cell Biology. 17: 12-9. PMID 15661514 DOI: 10.1016/J.Ceb.2004.12.004  1
2004 Tochtrop GP, King RW. Target identification strategies in chemical genetics. Combinatorial Chemistry & High Throughput Screening. 7: 677-88. PMID 15578930 DOI: 10.2174/1386207043328391  1
2004 Verma R, Peters NR, D'Onofrio M, Tochtrop GP, Sakamoto KM, Varadan R, Zhang M, Coffino P, Fushman D, Deshaies RJ, King RW. Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science (New York, N.Y.). 306: 117-20. PMID 15459393 DOI: 10.1126/Science.1100946  1
2004 Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule regulators of protein arginine methyltransferases. The Journal of Biological Chemistry. 279: 23892-9. PMID 15056663 DOI: 10.1074/Jbc.M401853200  1
2002 King RW. Roughing up Smoothened: chemical modulators of hedgehog signaling. Journal of Biology. 1: 8. PMID 12437769 DOI: 10.1186/1475-4924-1-8  1
2001 Walling LA, Peters NR, Horn EJ, King RW. New technologies for chemical genetics. Journal of Cellular Biochemistry. Supplement. 7-12. PMID 11842422 DOI: 10.1002/Jcb.10075  1
2001 Clemons PA, Koehler AN, Wagner BK, Sprigings TG, Spring DR, King RW, Schreiber SL, Foley MA. A one-bead, one-stock solution approach to chemical genetics: part 2. Chemistry & Biology. 8: 1183-95. PMID 11755397 DOI: 10.1016/S1074-5521(01)00086-2  1
2000 Haggarty SJ, Mayer TU, Miyamoto DT, Fathi R, King RW, Mitchison TJ, Schreiber SL. Dissecting cellular processes using small molecules: identification of colchicine-like, taxol-like and other small molecules that perturb mitosis. Chemistry & Biology. 7: 275-86. PMID 10780927 DOI: 10.1016/S1074-5521(00)00101-0  1
2000 Rotella DP, Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small-molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen Chemtracts. 13: 256-258.  1
1999 King RW. Chemistry or biology: which comes first after the genome is sequenced? Chemistry & Biology. 6: R327-33. PMID 10631509 DOI: 10.1016/S1074-5521(00)80002-2  1
1999 Mayer TU, Kapoor TM, Haggarty SJ, King RW, Schreiber SL, Mitchison TJ. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen. Science (New York, N.Y.). 286: 971-4. PMID 10542155 DOI: 10.1126/Science.286.5441.971  1
1998 Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science (New York, N.Y.). 279: 1219-22. PMID 9469815 DOI: 10.1126/Science.279.5354.1219  1
1997 Yamashita YM, Peters JM, King RW, Höög C, Kirschner MW, Zachariae W, Shin TH, Galova M, Obermaier B, Nasmyth K. BIME joins the destruction team. Trends in Cell Biology. 7: 49. PMID 17708905 DOI: 10.1016/S0962-8924(97)82669-4  0.96
1997 King RW, Lustig KD, Stukenberg PT, McGarry TJ, Kirschner MW. Expression cloning in the test tube. Science (New York, N.Y.). 277: 973-4. PMID 9281074 DOI: 10.1126/Science.277.5328.973  1
1997 Lustig KD, Stukenberg PT, McGarry TJ, King RW, Cryns VL, Mead PE, Zon LI, Yuan J, Kirschner MW. Small pool expression screening: identification of genes involved in cell cycle control, apoptosis, and early development. Methods in Enzymology. 283: 83-99. PMID 9251013 DOI: 10.1016/S0076-6879(97)83009-1  1
1997 Stukenberg PT, Lustig KD, McGarry TJ, King RW, Kuang J, Kirschner MW. Systematic identification of mitotic phosphoproteins. Current Biology : Cb. 7: 338-48. PMID 9115395 DOI: 10.1016/S0960-9822(06)00157-6  1
1996 King RW, Deshaies RJ, Peters JM, Kirschner MW. How proteolysis drives the cell cycle. Science (New York, N.Y.). 274: 1652-9. PMID 8939846 DOI: 10.1126/Science.274.5293.1652  1
1996 Peters JM, King RW, Höög C, Kirschner MW. Identification of BIME as a subunit of the anaphase-promoting complex. Science (New York, N.Y.). 274: 1199-201. PMID 8895470 DOI: 10.1126/Science.274.5290.1199  1
1996 King RW, Glotzer M, Kirschner MW. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Molecular Biology of the Cell. 7: 1343-57. PMID 8885231 DOI: 10.1091/Mbc.7.9.1343  1
1996 Yu H, King RW, Peters JM, Kirschner MW. Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation. Current Biology : Cb. 6: 455-66. PMID 8723350 DOI: 10.1016/S0960-9822(02)00513-4  1
1995 King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell. 81: 279-88. PMID 7736580 DOI: 10.1016/0092-8674(95)90338-0  1
1994 King RW, Jackson PK, Kirschner MW. Mitosis in transition. Cell. 79: 563-71. PMID 7954823 DOI: 10.1016/0092-8674(94)90542-8  1
1993 Holloway SL, Glotzer M, King RW, Murray AW. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell. 73: 1393-402. PMID 8391932 DOI: 10.1016/0092-8674(93)90364-V  1
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