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Year Citation  Score
2019 Song W, Kir S, Hong S, Hu Y, Wang X, Binari R, Tang HW, Chung V, Banks AS, Spiegelman B, Perrimon N. Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation. Developmental Cell. PMID 30639055 DOI: 10.1016/j.devcel.2018.12.003  0.36
2018 Chouchani ET, Kazak L, Spiegelman BM. New Advances in Adaptive Thermogenesis: UCP1 and Beyond. Cell Metabolism. PMID 30503034 DOI: 10.1016/j.cmet.2018.11.002  0.68
2018 Kong X, Yao T, Zhou P, Kazak L, Tenen D, Lyubetskaya A, Dawes BA, Tsai L, Kahn BB, Spiegelman BM, Liu T, Rosen ED. Brown Adipose Tissue Controls Skeletal Muscle Function via the Secretion of Myostatin. Cell Metabolism. PMID 30078553 DOI: 10.1016/j.cmet.2018.07.004  0.68
2018 Khandekar MJ, Banks AS, Laznik-Bogoslavski D, White JP, Choi JH, Kazak L, Lo JC, Cohen P, Wong KK, Kamenecka TM, Griffin PR, Spiegelman BM. Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy. Proceedings of the National Academy of Sciences of the United States of America. PMID 29295932 DOI: 10.1073/pnas.1717776115  0.68
2017 Kazak L, Chouchani ET, Lu GZ, Jedrychowski MP, Bare CJ, Mina AI, Kumari M, Zhang S, Vuckovic I, Laznik-Bogoslavski D, Dzeja P, Banks AS, Rosen ED, Spiegelman BM. Genetic Depletion of Adipocyte Creatine Metabolism Inhibits Diet-Induced Thermogenesis and Drives Obesity. Cell Metabolism. PMID 28844881 DOI: 10.1016/j.cmet.2017.08.009  0.68
2017 Chouchani ET, Kazak L, Spiegelman BM. Mitochondrial reactive oxygen species and adipose tissue thermogenesis: bridging physiology and mechanisms. The Journal of Biological Chemistry. PMID 28842500 DOI: 10.1074/jbc.R117.789628  0.68
2017 Kazak L, Chouchani ET, Stavrovskaya IG, Lu GZ, Jedrychowski MP, Egan DF, Kumari M, Kong X, Erickson BK, Szpyt J, Rosen ED, Murphy MP, Kristal BS, Gygi SP, Spiegelman BM. UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630339 DOI: 10.1073/pnas.1705406114  0.68
2017 Vishvanath L, Long JZ, Spiegelman BM, Gupta RK. Do Adipocytes Emerge from Mural Progenitors? Cell Stem Cell. 20: 585-586. PMID 28475882 DOI: 10.1016/j.stem.2017.03.013  0.44
2017 Bertholet AM, Kazak L, Chouchani ET, Bogaczyńska MG, Paranjpe I, Wainwright GL, Bétourné A, Kajimura S, Spiegelman BM, Kirichok Y. Mitochondrial Patch Clamp of Beige Adipocytes Reveals UCP1-Positive and UCP1-Negative Cells Both Exhibiting Futile Creatine Cycling. Cell Metabolism. 25: 811-822.e4. PMID 28380374 DOI: 10.1016/j.cmet.2017.03.002  0.68
2016 Kir S, Spiegelman BM. Cachexia and Brown Fat: A Burning Issue in Cancer. Trends in Cancer. 2: 461-463. PMID 28741475 DOI: 10.1016/j.trecan.2016.07.005  0.36
2016 Kir S, Spiegelman BM. CACHEXIA & BROWN FAT: A BURNING ISSUE IN CANCER. Trends in Cancer. 2: 461-463. PMID 28459108 DOI: 10.1016/j.trecan.2016.07.005  0.36
2016 Zeng X, Jedrychowski MP, Chen Y, Serag S, Lavery GG, Gygi SP, Spiegelman BM. Lysine-specific demethylase 1 promotes brown adipose tissue thermogenesis via repressing glucocorticoid activation. Genes & Development. PMID 27566776 DOI: 10.1101/gad.285312.116  0.84
2016 Cohen P, Spiegelman BM. Cell biology of fat storage. Molecular Biology of the Cell. 27: 2523-7. PMID 27528697 DOI: 10.1091/mbc.E15-10-0749  0.36
2016 Long JZ, Svensson KJ, Bateman LA, Lin H, Kamenecka T, Lokurkar IA, Lou J, Rao RR, Chang MR, Jedrychowski MP, Paulo JA, Gygi SP, Griffin PR, Nomura DK, Spiegelman BM. The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria. Cell. PMID 27374330 DOI: 10.1016/j.cell.2016.05.071  0.84
2016 Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM. Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. PMID 27281219 DOI: 10.1038/nature18279  0.68
2016 Conceição MS, Chacon-Mikahil MP, Telles GD, Libardi CA, Junior EM, Vechin FC, Andrade AL, Gáspari AF, Brum PC, Cavaglieri CR, Serag S, Spiegelman BM, Hawley JA, Camera DM. Attenuated PGC-1α Isoforms following Endurance Exercise with Blood Flow Restriction. Medicine and Science in Sports and Exercise. PMID 27128665 DOI: 10.1249/MSS.0000000000000970  0.84
2016 Chouchani ET, Kazak L, Jedrychowski MP, Lu GZ, Erickson BK, Szpyt J, Pierce KA, Laznik-Bogoslavski D, Vetrivelan R, Clish CB, Robinson AJ, Gygi SP, Spiegelman BM. Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. Nature. PMID 27027295 DOI: 10.1038/nature17399  0.84
2016 Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Chédotal A, Kajimura S, Gygi SP, Spiegelman BM. A Secreted Slit2 Fragment Regulates Adipose Tissue Thermogenesis and Metabolic Function. Cell Metabolism. PMID 26876562 DOI: 10.1016/j.cmet.2016.01.008  0.84
2015 Kir S, Komaba H, Garcia AP, Economopoulos KP, Liu W, Lanske B, Hodin RA, Spiegelman BM. PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. Cell Metabolism. PMID 26669699 DOI: 10.1016/j.cmet.2015.11.003  0.84
2015 Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P, Vetrivelan R, Lu GZ, Laznik-Bogoslavski D, Hasenfuss SC, Kajimura S, Gygi SP, Spiegelman BM. A Creatine-Driven Substrate Cycle Enhances Energy Expenditure and Thermogenesis in Beige Fat. Cell. 163: 643-55. PMID 26496606 DOI: 10.1016/j.cell.2015.09.035  0.84
2015 Kajimura S, Spiegelman BM, Seale P. Brown and Beige Fat: Physiological Roles beyond Heat Generation. Cell Metabolism. 22: 546-59. PMID 26445512 DOI: 10.1016/j.cmet.2015.09.007  0.84
2015 Cohen P, Spiegelman BM. Brown and Beige Fat: Molecular Parts of a Thermogenic Machine. Diabetes. 64: 2346-51. PMID 26050670 DOI: 10.2337/db15-0318  0.36
2015 Liu X, Xiao J, Zhu H, Wei X, Platt C, Damilano F, Xiao C, Bezzerides V, Boström P, Che L, Zhang C, Spiegelman BM, Rosenzweig A. miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell Metabolism. 21: 584-95. PMID 25863248 DOI: 10.1016/j.cmet.2015.02.014  0.84
2015 Irving BA, Lanza IR, Henderson GC, Rao RR, Spiegelman BM, Nair KS. Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age. The Journal of Clinical Endocrinology and Metabolism. 100: 1654-63. PMID 25599385 DOI: 10.1210/jc.2014-3081  0.84
2015 Cipolletta D, Cohen P, Spiegelman BM, Benoist C, Mathis D. Appearance and disappearance of the mRNA signature characteristic of Treg cells in visceral adipose tissue: age, diet, and PPARγ effects. Proceedings of the National Academy of Sciences of the United States of America. 112: 482-7. PMID 25550516 DOI: 10.1073/pnas.1423486112  0.84
2015 Banks AS, McAllister FE, Camporez JP, Zushin PJ, Jurczak MJ, Laznik-Bogoslavski D, Shulman GI, Gygi SP, Spiegelman BM. An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ. Nature. 517: 391-5. PMID 25409143 DOI: 10.1038/nature13887  0.84
2015 Jedrychowski MP, Wrann CD, Paulo JA, Gerber KK, Szpyt J, Robinson MM, Nair KS, Gygi SP, Spiegelman BM. Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry Cell Metabolism. DOI: 10.1016/j.cmet.2015.08.001  0.84
2014 White JP, Wrann CD, Rao RR, Nair SK, Jedrychowski MP, You JS, Martínez-Redondo V, Gygi SP, Ruas JL, Hornberger TA, Wu Z, Glass DJ, Piao X, Spiegelman BM. G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. Proceedings of the National Academy of Sciences of the United States of America. 111: 15756-61. PMID 25336758 DOI: 10.1073/pnas.1417898111  0.84
2014 Choi JH, Choi SS, Kim ES, Jedrychowski MP, Yang YR, Jang HJ, Suh PG, Banks AS, Gygi SP, Spiegelman BM. Thrap3 docks on phosphoserine 273 of PPARγ and controls diabetic gene programming. Genes & Development. 28: 2361-9. PMID 25316675 DOI: 10.1101/gad.249367.114  0.84
2014 Spiegelman BM, Wrann C. Response to Comment on Wu and Spiegelman. Irisin ERKs the fat. Diabetes 2014;63:381-383. Diabetes. 63: e17. PMID 25146478 DOI: 10.2337/db14-0898  0.84
2014 Kir S, White JP, Kleiner S, Kazak L, Cohen P, Baracos VE, Spiegelman BM. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature. 513: 100-4. PMID 25043053 DOI: 10.1038/nature13528  0.84
2014 Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, et al. IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell. 158: 69-83. PMID 24995979 DOI: 10.1016/j.cell.2014.04.049  0.84
2014 Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, ... ... Spiegelman BM, et al. Adipsin is an adipokine that improves β cell function in diabetes. Cell. 158: 41-53. PMID 24995977 DOI: 10.1016/j.cell.2014.06.005  0.84
2014 Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, ... Spiegelman BM, et al. Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 157: 1279-91. PMID 24906147 DOI: 10.1016/j.cell.2014.03.065  0.84
2014 Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X, Rao RR, Lou J, Lokurkar I, Baur W, Castellot JJ, Rosen ED, Spiegelman BM. A smooth muscle-like origin for beige adipocytes. Cell Metabolism. 19: 810-20. PMID 24709624 DOI: 10.1016/j.cmet.2014.03.025  0.84
2014 Wu J, Spiegelman BM. Irisin ERKs the fat. Diabetes. 63: 381-3. PMID 24464712 DOI: 10.2337/db13-1586  0.84
2014 Cohen P, Levy JD, Zhang Y, Frontini A, Kolodin DP, Svensson KJ, Lo JC, Zeng X, Ye L, Khandekar MJ, Wu J, Gunawardana SC, Banks AS, Camporez JP, Jurczak MJ, ... ... Spiegelman BM, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell. 156: 304-16. PMID 24439384 DOI: 10.1016/j.cell.2013.12.021  0.84
2014 Rosen ED, Spiegelman BM. What we talk about when we talk about fat. Cell. 156: 20-44. PMID 24439368 DOI: 10.1016/j.cell.2013.12.012  0.84
2014 Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, ... ... Spiegelman BM, et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metabolism. 19: 96-108. PMID 24411942 DOI: 10.1016/j.cmet.2013.12.003  0.84
2013 Wrann CD, White JP, Salogiannnis J, Laznik-Bogoslavski D, Wu J, Ma D, Lin JD, Greenberg ME, Spiegelman BM. Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. Cell Metabolism. 18: 649-59. PMID 24120943 DOI: 10.1016/j.cmet.2013.09.008  0.84
2013 Goswami D, Devarakonda S, Chalmers MJ, Pascal BD, Spiegelman BM, Griffin PR. Time window expansion for HDX analysis of an intrinsically disordered protein. Journal of the American Society For Mass Spectrometry. 24: 1584-92. PMID 23884631 DOI: 10.1007/s13361-013-0669-y  0.84
2013 Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP, Spiegelman BM. Fat cells directly sense temperature to activate thermogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 12480-5. PMID 23818608 DOI: 10.1073/pnas.1310261110  0.84
2013 Spiegelman BM. Banting Lecture 2012: Regulation of adipogenesis: toward new therapeutics for metabolic disease. Diabetes. 62: 1774-82. PMID 23704518 DOI: 10.2337/db12-1665  0.84
2013 Adamovich Y, Shlomai A, Tsvetkov P, Umansky KB, Reuven N, Estall JL, Spiegelman BM, Shaul Y. The protein level of PGC-1α, a key metabolic regulator, is controlled by NADH-NQO1. Molecular and Cellular Biology. 33: 2603-13. PMID 23648480 DOI: 10.1128/MCB.01672-12  0.84
2013 Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, Clish CB, Granter SR, Widlund HR, Spiegelman BM, Puigserver P. PGC1α expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell. 23: 287-301. PMID 23416000 DOI: 10.1016/j.ccr.2012.11.020  0.84
2013 Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes & Development. 27: 234-50. PMID 23388824 DOI: 10.1101/gad.211649.112  0.84
2012 Ruas JL, White JP, Rao RR, Kleiner S, Brannan KT, Harrison BC, Greene NP, Wu J, Estall JL, Irving BA, Lanza IR, Rasbach KA, Okutsu M, Nair KS, Yan Z, ... ... Spiegelman BM, et al. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell. 151: 1319-31. PMID 23217713 DOI: 10.1016/j.cell.2012.10.050  0.84
2012 Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar MJ, Boström P, Mepani RJ, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, ... ... Spiegelman BM, et al. TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. Cell. 151: 96-110. PMID 23021218 DOI: 10.1016/j.cell.2012.08.034  0.84
2012 Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, ... ... Spiegelman BM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 150: 366-76. PMID 22796012 DOI: 10.1016/j.cell.2012.05.016  0.84
2012 Glass DJ, Spiegelman BM. Se-Jin Lee, myostatin discoverer, elected to the National Academy of Science. Skeletal Muscle. 2: 11. PMID 22676848 DOI: 10.1186/2044-5040-2-11  0.84
2012 Kleiner S, Mepani RJ, Laznik D, Ye L, Jurczak MJ, Jornayvaz FR, Estall JL, Chatterjee Bhowmick D, Shulman GI, Spiegelman BM. Development of insulin resistance in mice lacking PGC-1α in adipose tissues. Proceedings of the National Academy of Sciences of the United States of America. 109: 9635-40. PMID 22645355 DOI: 10.1073/pnas.1207287109  0.84
2012 Da Cruz S, Parone PA, Lopes VS, Lillo C, McAlonis-Downes M, Lee SK, Vetto AP, Petrosyan S, Marsala M, Murphy AN, Williams DS, Spiegelman BM, Cleveland DW. Elevated PGC-1α activity sustains mitochondrial biogenesis and muscle function without extending survival in a mouse model of inherited ALS. Cell Metabolism. 15: 778-86. PMID 22560226 DOI: 10.1016/j.cmet.2012.03.019  0.84
2012 Koncarevic A, Kajimura S, Cornwall-Brady M, Andreucci A, Pullen A, Sako D, Kumar R, Grinberg AV, Liharska K, Ucran JA, Howard E, Spiegelman BM, Seehra J, Lachey J. A novel therapeutic approach to treating obesity through modulation of TGFβ signaling. Endocrinology. 153: 3133-46. PMID 22549226 DOI: 10.1210/en.2012-1016  0.84
2012 Kitami T, Logan DJ, Negri J, Hasaka T, Tolliday NJ, Carpenter AE, Spiegelman BM, Mootha VK. A chemical screen probing the relationship between mitochondrial content and cell size. Plos One. 7: e33755. PMID 22479437 DOI: 10.1371/journal.pone.0033755  0.84
2012 Ohno H, Shinoda K, Spiegelman BM, Kajimura S. PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein. Cell Metabolism. 15: 395-404. PMID 22405074 DOI: 10.1016/j.cmet.2012.01.019  0.84
2012 Gupta RK, Mepani RJ, Kleiner S, Lo JC, Khandekar MJ, Cohen P, Frontini A, Bhowmick DC, Ye L, Cinti S, Spiegelman BM. Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells. Cell Metabolism. 15: 230-9. PMID 22326224 DOI: 10.1016/j.cmet.2012.01.010  0.84
2012 Fisher FM, Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J, Kharitonenkov A, Flier JS, Maratos-Flier E, Spiegelman BM. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes & Development. 26: 271-81. PMID 22302939 DOI: 10.1101/gad.177857.111  0.84
2012 Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, ... ... Spiegelman BM, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 481: 463-8. PMID 22237023 DOI: 10.1038/nature10777  0.84
2012 Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, Rasbach KA, Boström EA, Choi JH, Long JZ, Kajimura S, Zingaretti MC, Vind BF, Tu H, Cinti S, ... ... Spiegelman BM, et al. Boström et al. reply Nature. 488: E10-E11. DOI: 10.1038/nature11365  0.84
2011 Gupta RK, Rosen ED, Spiegelman BM. Identifying novel transcriptional components controlling energy metabolism. Cell Metabolism. 14: 739-45. PMID 22152302 DOI: 10.1016/j.cmet.2011.11.007  0.84
2011 Khandekar MJ, Cohen P, Spiegelman BM. Molecular mechanisms of cancer development in obesity. Nature Reviews. Cancer. 11: 886-95. PMID 22113164 DOI: 10.1038/nrc3174  0.84
2011 Devarakonda S, Gupta K, Chalmers MJ, Hunt JF, Griffin PR, Van Duyne GD, Spiegelman BM. Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex. Proceedings of the National Academy of Sciences of the United States of America. 108: 18678-83. PMID 22049338 DOI: 10.1073/pnas.1113813108  0.84
2011 Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, ... ... Spiegelman BM, et al. Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature. 477: 477-81. PMID 21892191 DOI: 10.1038/nature10383  0.84
2011 Fisher FM, Estall JL, Adams AC, Antonellis PJ, Bina HA, Flier JS, Kharitonenkov A, Spiegelman BM, Maratos-Flier E. Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology. 152: 2996-3004. PMID 21712364 DOI: 10.1210/en.2011-0281  0.84
2011 Lustig Y, Ruas JL, Estall JL, Lo JC, Devarakonda S, Laznik D, Choi JH, Ono H, Olsen JV, Spiegelman BM. Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes & Development. 25: 1232-44. PMID 21646374 DOI: 10.1101/gad.2054711  0.84
2011 Handschin C, Spiegelman BM. PGC-1 coactivators and the regulation of skeletal muscle fiber-type determination. Cell Metabolism. 13: 351; author reply 35. PMID 21459315 DOI: 10.1016/j.cmet.2011.03.008  0.84
2011 Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. The unfolded protein response mediates adaptation to exercise in skeletal muscle through a PGC-1α/ATF6α complex. Cell Metabolism. 13: 160-9. PMID 21284983 DOI: 10.1016/j.cmet.2011.01.003  0.84
2011 Seale P, Conroe HM, Estall J, Kajimura S, Frontini A, Ishibashi J, Cohen P, Cinti S, Spiegelman BM. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. The Journal of Clinical Investigation. 121: 96-105. PMID 21123942 DOI: 10.1172/JCI44271  0.84
2010 Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panáková D, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM. C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 143: 1072-83. PMID 21183071 DOI: 10.1016/j.cell.2010.11.036  0.84
2010 Rasbach KA, Gupta RK, Ruas JL, Wu J, Naseri E, Estall JL, Spiegelman BM. PGC-1alpha regulates a HIF2alpha-dependent switch in skeletal muscle fiber types. Proceedings of the National Academy of Sciences of the United States of America. 107: 21866-71. PMID 21106753 DOI: 10.1073/pnas.1016089107  0.84
2010 Chakkalakal JV, Nishimune H, Ruas JL, Spiegelman BM, Sanes JR. Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons. Development (Cambridge, England). 137: 3489-99. PMID 20843861 DOI: 10.1242/dev.053348  0.84
2010 Choi JH, Banks AS, Estall JL, Kajimura S, Boström P, Laznik D, Ruas JL, Chalmers MJ, Kamenecka TM, Blüher M, Griffin PR, Spiegelman BM. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature. 466: 451-6. PMID 20651683 DOI: 10.1038/nature09291  0.84
2010 Volakakis N, Kadkhodaei B, Joodmardi E, Wallis K, Panman L, Silvaggi J, Spiegelman BM, Perlmann T. NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection. Proceedings of the National Academy of Sciences of the United States of America. 107: 12317-22. PMID 20566846 DOI: 10.1073/pnas.1007088107  0.84
2010 Kajimura S, Seale P, Spiegelman BM. Transcriptional control of brown fat development. Cell Metabolism. 11: 257-62. PMID 20374957 DOI: 10.1016/j.cmet.2010.03.005  0.84
2010 Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM, Roby YA, Kulaga H, Reed RR, Spiegelman BM. Transcriptional control of preadipocyte determination by Zfp423. Nature. 464: 619-23. PMID 20200519 DOI: 10.1038/nature08816  0.84
2010 Handschin C, Summermatter S, LeBrasseur NK, Lin J, Spiegelman BM. For a pragmatic approach to exercise studies. Journal of Applied Physiology (Bethesda, Md. : 1985). 108: 223-3; author reply . PMID 20066760  0.84
2009 Estall JL, Ruas JL, Choi CS, Laznik D, Badman M, Maratos-Flier E, Shulman GI, Spiegelman BM. PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proceedings of the National Academy of Sciences of the United States of America. 106: 22510-5. PMID 20018698 DOI: 10.1073/pnas.0912533106  0.84
2009 Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proceedings of the National Academy of Sciences of the United States of America. 106: 20405-10. PMID 19918075 DOI: 10.1073/pnas.0911570106  0.84
2009 Kajimura S, Seale P, Kubota K, Lunsford E, Frangioni JV, Gygi SP, Spiegelman BM. Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex. Nature. 460: 1154-8. PMID 19641492 DOI: 10.1038/nature08262  0.84
2009 Kleiner S, Nguyen-Tran V, Baré O, Huang X, Spiegelman B, Wu Z. PPAR{delta} agonism activates fatty acid oxidation via PGC-1{alpha} but does not increase mitochondrial gene expression and function. The Journal of Biological Chemistry. 284: 18624-33. PMID 19435887 DOI: 10.1074/jbc.M109.008797  0.84
2009 Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes. 58: 1499-508. PMID 19366863 DOI: 10.2337/db08-1571  0.84
2009 Seale P, Kajimura S, Spiegelman BM. Transcriptional control of brown adipocyte development and physiological function--of mice and men. Genes & Development. 23: 788-97. PMID 19339685 DOI: 10.1101/gad.1779209  0.84
2008 Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, ... Spiegelman BM, et al. Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proceedings of the National Academy of Sciences of the United States of America. 105: 19926-31. PMID 19066218 DOI: 10.1073/pnas.0810339105  0.84
2008 Girnun GD, Chen L, Silvaggi J, Drapkin R, Chirieac LR, Padera RF, Upadhyay R, Vafai SB, Weissleder R, Mahmood U, Naseri E, Buckley S, Li D, Force J, McNamara K, ... ... Spiegelman BM, et al. Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 6478-86. PMID 18927287 DOI: 10.1158/1078-0432.CCR-08-1128  0.84
2008 Wenz T, Diaz F, Spiegelman BM, Moraes CT. Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metabolism. 8: 249-56. PMID 18762025 DOI: 10.1016/j.cmet.2008.07.006  0.84
2008 Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. The Journal of Biological Chemistry. 283: 31960-7. PMID 18728005 DOI: 10.1074/jbc.M805431200  0.84
2008 Seale P, Bjork B, Yang W, Kajimura S, Chin S, Kuang S, Scimè A, Devarakonda S, Conroe HM, Erdjument-Bromage H, Tempst P, Rudnicki MA, Beier DR, Spiegelman BM. PRDM16 controls a brown fat/skeletal muscle switch. Nature. 454: 961-7. PMID 18719582 DOI: 10.1038/nature07182  0.84
2008 Handschin C, Spiegelman BM. The role of exercise and PGC1alpha in inflammation and chronic disease. Nature. 454: 463-9. PMID 18650917 DOI: 10.1038/nature07206  0.84
2008 Walkey CJ, Spiegelman BM. A functional peroxisome proliferator-activated receptor-gamma ligand-binding domain is not required for adipogenesis. The Journal of Biological Chemistry. 283: 24290-4. PMID 18622018 DOI: 10.1074/jbc.C800139200  0.84
2008 Tontonoz P, Spiegelman BM. Fat and beyond: the diverse biology of PPARgamma. Annual Review of Biochemistry. 77: 289-312. PMID 18518822 DOI: 10.1146/annurev.biochem.77.061307.091829  0.84
2008 Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes & Development. 22: 1397-409. PMID 18483224 DOI: 10.1101/gad.1666108  0.84
2008 Arany Z, Wagner BK, Ma Y, Chinsomboon J, Laznik D, Spiegelman BM. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1alpha and oxidative phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 105: 4721-6. PMID 18347329 DOI: 10.1073/pnas.0800979105  0.84
2008 Arany Z, Foo SY, Ma Y, Ruas JL, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala SM, Baek KH, Rosenzweig A, Spiegelman BM. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1alpha. Nature. 451: 1008-12. PMID 18288196 DOI: 10.1038/nature06613  0.84
2008 Calvo JA, Daniels TG, Wang X, Paul A, Lin J, Spiegelman BM, Stevenson SC, Rangwala SM. Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake. Journal of Applied Physiology (Bethesda, Md. : 1985). 104: 1304-12. PMID 18239076 DOI: 10.1152/japplphysiol.01231.2007  0.84
2008 Spiegelman B. The skinny fat Scientist. 22: 29-34.  0.84
2007 Farmer SR, Spiegelman BM. Cell Differentiation. Current Opinion in Cell Biology. 19: 603-604. PMID 19050740 DOI: 10.1016/j.ceb.2007.11.002  0.84
2007 Spiegelman BM. Transcriptional control of energy homeostasis through the PGC1 coactivators. Novartis Foundation Symposium. 286: 3-6; discusssion 6-1. PMID 18269170  0.84
2007 Spiegelman BM. Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators. Novartis Foundation Symposium. 287: 60-3; discussion 63-. PMID 18074631 DOI: 10.1002/9780470725207.ch5  0.84
2007 Handschin C, Choi CS, Chin S, Kim S, Kawamori D, Kurpad AJ, Neubauer N, Hu J, Mootha VK, Kim YB, Kulkarni RN, Shulman GI, Spiegelman BM. Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk. The Journal of Clinical Investigation. 117: 3463-74. PMID 17932564 DOI: 10.1172/JCI31785  0.84
2007 Handschin C, Chin S, Li P, Liu F, Maratos-Flier E, Lebrasseur NK, Yan Z, Spiegelman BM. Skeletal muscle fiber-type switching, exercise intolerance, and myopathy in PGC-1alpha muscle-specific knock-out animals. The Journal of Biological Chemistry. 282: 30014-21. PMID 17702743 DOI: 10.1074/jbc.M704817200  0.84
2007 Seale P, Kajimura S, Yang W, Chin S, Rohas LM, Uldry M, Tavernier G, Langin D, Spiegelman BM. Transcriptional control of brown fat determination by PRDM16. Cell Metabolism. 6: 38-54. PMID 17618855 DOI: 10.1016/j.cmet.2007.06.001  0.84
2007 Jäger S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proceedings of the National Academy of Sciences of the United States of America. 104: 12017-22. PMID 17609368 DOI: 10.1073/pnas.0705070104  0.84
2007 Girnun GD, Naseri E, Vafai SB, Qu L, Szwaya JD, Bronson R, Alberta JA, Spiegelman BM. Synergy between PPARgamma ligands and platinum-based drugs in cancer. Cancer Cell. 11: 395-406. PMID 17482130 DOI: 10.1016/j.ccr.2007.02.025  0.84
2007 Rohas LM, St-Pierre J, Uldry M, Jäger S, Handschin C, Spiegelman BM. A fundamental system of cellular energy homeostasis regulated by PGC-1alpha. Proceedings of the National Academy of Sciences of the United States of America. 104: 7933-8. PMID 17470778 DOI: 10.1073/pnas.0702683104  0.84
2007 Handschin C, Kobayashi YM, Chin S, Seale P, Campbell KP, Spiegelman BM. PGC-1alpha regulates the neuromuscular junction program and ameliorates Duchenne muscular dystrophy. Genes & Development. 21: 770-83. PMID 17403779 DOI: 10.1101/gad.1525107  0.84
2007 Arany Z, Lebrasseur N, Morris C, Smith E, Yang W, Ma Y, Chin S, Spiegelman BM. The transcriptional coactivator PGC-1beta drives the formation of oxidative type IIX fibers in skeletal muscle. Cell Metabolism. 5: 35-46. PMID 17189205 DOI: 10.1016/j.cmet.2006.12.003  0.84
2007 Nicholls DG, Larsson NG, Spiegelman BM, Jacobs HT, Brand MD, Lemasters JJ, Martinou JC, O'Rourke B, Shirihai O, Turnbull DM, Halestrap AP, Schon EA, Giulivi C. Discussion Novartis Foundation Symposium. 287: 208-213.  0.84
2007 Tabas I, Black PN, Spiegelman BM, O'Rahilly S, Bernlohr DA, Glass CK, Muoio DM, Attie AD. Final discussion: Nutrition, ageing and lipotoxicity Novartis Foundation Symposium. 286: 200-203.  0.84
2007 Spiegelman BM. Chair's introduction Novartis Foundation Symposium. 286: 1-2.  0.84
2007 Saito M, Spiegelman BM, Glass CK, O'Rahilly S, Muoio DM, Shi Y. General discussion I Novartis Foundation Symposium. 286: 162-163.  0.84
2007 Spiegelman BM, Brand MD, Nicholls DG, Giulivi C, Adam-Vizi V, Larsson NG, Beal MF, Lemasters JJ, O'Rourke B, Reynolds IJ, Halestrap AP, Orrenius S, Bernardi P, Schon EA, Bednarczyk P, et al. Discussion Novartis Foundation Symposium. 287: 80-91.  0.84
2007 Nicholls DG, Larsson NG, Spiegelman BM, Jacobs HT, Brand MD, Lemasters JJ, Martinou JC, O'Rourke B, Shirihai O, Turnbull DM, Halestrap AP, Schon EA, Giulivi C. Discussion Novartis Foundation Symposium. 287: 208-213.  0.84
2007 Li P, Carling D, Hotamisligil GS, Bernlohr DA, Attie AD, Kim JB, Spiegelman BM. Discussion Novartis Foundation Symposium. 286: 81-85.  0.84
2006 Spiegelman BM, Enerbäck S. "The adipocyte: a multifunctional cell". Cell Metabolism. 4: 425-7. PMID 17211937 DOI: 10.1016/j.cmet.2006.11.009  0.84
2006 Rosen ED, Spiegelman BM. Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 444: 847-53. PMID 17167472 DOI: 10.1038/nature05483  0.84
2006 Vianna CR, Huntgeburth M, Coppari R, Choi CS, Lin J, Krauss S, Barbatelli G, Tzameli I, Kim YB, Cinti S, Shulman GI, Spiegelman BM, Lowell BB. Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance. Cell Metabolism. 4: 453-64. PMID 17141629 DOI: 10.1016/j.cmet.2006.11.003  0.84
2006 Michalik L, Auwerx J, Berger JP, Chatterjee VK, Glass CK, Gonzalez FJ, Grimaldi PA, Kadowaki T, Lazar MA, O'Rahilly S, Palmer CN, Plutzky J, Reddy JK, Spiegelman BM, Staels B, et al. International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors. Pharmacological Reviews. 58: 726-41. PMID 17132851 DOI: 10.1124/pr.58.4.5  0.84
2006 St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 127: 397-408. PMID 17055439 DOI: 10.1016/j.cell.2006.09.024  0.84
2006 Sandri M, Lin J, Handschin C, Yang W, Arany ZP, Lecker SH, Goldberg AL, Spiegelman BM. PGC-1alpha protects skeletal muscle from atrophy by suppressing FoxO3 action and atrophy-specific gene transcription. Proceedings of the National Academy of Sciences of the United States of America. 103: 16260-5. PMID 17053067 DOI: 10.1073/pnas.0607795103  0.84
2006 Cooper MP, Qu L, Rohas LM, Lin J, Yang W, Erdjument-Bromage H, Tempst P, Spiegelman BM. Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes & Development. 20: 2996-3009. PMID 17050673 DOI: 10.1101/gad.1483906  0.84
2006 Handschin C, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocrine Reviews. 27: 728-35. PMID 17018837 DOI: 10.1210/er.2006-0037  0.84
2006 Wu Z, Huang X, Feng Y, Handschin C, Feng Y, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC. Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proceedings of the National Academy of Sciences of the United States of America. 103: 14379-84. PMID 16980408 DOI: 10.1073/pnas.0606714103  0.84
2006 Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, Spiegelman BM. Transverse aortic constriction leads to accelerated heart failure in mice lacking PPAR-gamma coactivator 1alpha. Proceedings of the National Academy of Sciences of the United States of America. 103: 10086-91. PMID 16775082 DOI: 10.1073/pnas.0603615103  0.84
2006 Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation. Cell Metabolism. 3: 333-41. PMID 16679291 DOI: 10.1016/j.cmet.2006.04.002  0.84
2006 Rhee J, Ge H, Yang W, Fan M, Handschin C, Cooper M, Lin J, Li C, Spiegelman BM. Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. The Journal of Biological Chemistry. 281: 14683-90. PMID 16574644 DOI: 10.1074/jbc.M512636200  0.84
2006 Uldry M, Yang W, St-Pierre J, Lin J, Seale P, Spiegelman BM. Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation (DOI:10.1016/j.cmet.2006.04.002) Cell Metabolism. 4: 97. DOI: 10.1016/j.cmet.2006.06.005  0.84
2005 Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metabolism. 2: 227-38. PMID 16213225 DOI: 10.1016/j.cmet.2005.08.010  0.84
2005 Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell. 122: 505-15. PMID 16122419 DOI: 10.1016/j.cell.2005.06.040  0.84
2005 Hong JH, Hwang ES, McManus MT, Amsterdam A, Tian Y, Kalmukova R, Mueller E, Benjamin T, Spiegelman BM, Sharp PA, Hopkins N, Yaffe MB. TAZ, a transcriptional modulator of mesenchymal stem cell differentiation. Science (New York, N.Y.). 309: 1074-8. PMID 16099986 DOI: 10.1126/science.1110955  0.84
2005 Lin J, Handschin C, Spiegelman BM. Metabolic control through the PGC-1 family of transcription coactivators Cell Metabolism. 1: 361-370. PMID 16054085 DOI: 10.1016/j.cmet.2005.05.004  0.84
2005 Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, ... ... Spiegelman BM, et al. Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle. Cell Metabolism. 1: 259-71. PMID 16054070 DOI: 10.1016/j.cmet.2005.03.002  0.84
2005 Chen Z, Torrens JI, Anand A, Spiegelman BM, Friedman JM. Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metabolism. 1: 93-106. PMID 16054051 DOI: 10.1016/j.cmet.2004.12.009  0.84
2005 Andersen G, Wegner L, Yanagisawa K, Rose CS, Lin J, Glümer C, Drivsholm T, Borch-Johnsen K, Jørgensen T, Hansen T, Spiegelman BM, Pedersen O. Evidence of an association between genetic variation of the coactivator PGC-1β and obesity Journal of Medical Genetics. 42: 402-407. PMID 15863669 DOI: 10.1136/jmg.2004.026278  0.84
2005 Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature. 434: 113-8. PMID 15744310 DOI: 10.1038/nature03354  0.84
2005 Drori S, Girnun GD, Tou L, Szwaya JD, Mueller E, Xia K, Kia X, Shivdasani RA, Spiegelman BM. Hic-5 regulates an epithelial program mediated by PPARgamma. Genes & Development. 19: 362-75. PMID 15687259 DOI: 10.1101/gad.1240705  0.84
2005 Lin J, Yang R, Tarr PT, Wu PH, Handschin C, Li S, Yang W, Pei L, Uldry M, Tontonoz P, Newgard CB, Spiegelman BM. Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. Cell. 120: 261-73. PMID 15680331 DOI: 10.1016/j.cell.2004.11.043  0.84
2005 Brown M, Flier J, Friedman J, Goldstein J, Kahn CR, Lifton R, O'Rahilly S, Spiegelman B. Cell Metabolism: Why, and why now? Cell Metabolism. 1: 3. DOI: 10.1016/j.cmet.2004.12.007  0.84
2004 Spiegelman BM, Heinrich R. Biological control through regulated transcriptional coactivators. Cell. 119: 157-67. PMID 15479634 DOI: 10.1016/j.cell.2004.09.037  0.84
2004 Smith MR, Manola J, Kaufman DS, George D, Oh WK, Mueller E, Slovin S, Spiegelman B, Small E, Kantoff PW. Rosiglitazone versus placebo for men with prostate carcinoma and a rising serum prostate-specific antigen level after radical prostatectomy and/or radiation therapy Cancer. 101: 1569-1574. PMID 15468186 DOI: 10.1002/cncr.20493  0.84
2004 Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, ... ... Spiegelman BM, et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 119: 121-35. PMID 15454086 DOI: 10.1016/j.cell.2004.09.013  0.84
2004 Mootha VK, Handschin C, Arlow D, Xie X, St Pierre J, Sihag S, Yang W, Altshuler D, Puigserver P, Patterson N, Willy PJ, Schulman IG, Heyman RA, Lander ES, Spiegelman BM. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proceedings of the National Academy of Sciences of the United States of America. 101: 6570-5. PMID 15100410 DOI: 10.1073/pnas.0401401101  0.84
2004 Cao W, Daniel KW, Robidoux J, Puigserver P, Medvedev AV, Bai X, Floering LM, Spiegelman BM, Collins S. p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene. Molecular and Cellular Biology. 24: 3057-67. PMID 15024092 DOI: 10.1128/MCB.24.7.3057-3067.2004  0.84
2004 Fan M, Rhee J, St-Pierre J, Handschin C, Puigserver P, Lin J, Jäeger S, Erdjument-Bromage H, Tempst P, Spiegelman BM. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes & Development. 18: 278-89. PMID 14744933 DOI: 10.1101/gad.1152204  0.84
2003 Wallberg AE, Yamamura S, Malik S, Spiegelman BM, Roeder RG. Coordination of p300-mediated chromatin remodeling and TRAP/mediator function through coactivator PGC-1α Molecular Cell. 12: 1137-1149. PMID 14636573 DOI: 10.1016/S1097-2765(03)00391-5  0.84
2003 Rosen ED, Kulkarni RN, Sarraf P, Ozcan U, Okada T, Hsu CH, Eisenman D, Magnuson MA, Gonzalez FJ, Kahn CR, Spiegelman BM. Targeted elimination of peroxisome proliferator-activated receptor gamma in beta cells leads to abnormalities in islet mass without compromising glucose homeostasis. Molecular and Cellular Biology. 23: 7222-9. PMID 14517292 DOI: 10.1128/MCB.23.20.7222-7229.2003  0.84
2003 Norris AW, Chen L, Fisher SJ, Szanto I, Ristow M, Jozsi AC, Hirshman MF, Rosen ED, Goodyear LJ, Gonzalez FJ, Spiegelman BM, Kahn CR. Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. The Journal of Clinical Investigation. 112: 608-18. PMID 12925701 DOI: 10.1172/JCI17305  0.84
2003 Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Developmental Cell. 5: 73-83. PMID 12852853 DOI: 10.1016/S1534-5807(03)00170-9  0.84
2003 Burstein HJ, Demetri GD, Mueller E, Sarraf P, Spiegelman BM, Winer EP. Use of the peroxisome proliferator-activated receptor (PPAR) γ ligand troglitazone as treatment for refractory breast cancer: A phase II study Breast Cancer Research and Treatment. 79: 391-397. PMID 12846423 DOI: 10.1023/A:1024038127156  0.84
2003 Mootha VK, Lindgren CM, Eriksson KF, Subramanian A, Sihag S, Lehar J, Puigserver P, Carlsson E, RidderstrÃ¥le M, Laurila E, Houstis N, Daly MJ, Patterson N, Mesirov JP, Golub TR, ... ... Spiegelman B, et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genetics. 34: 267-73. PMID 12808457 DOI: 10.1038/ng1180  0.84
2003 Lin J, Tarr PT, Yang R, Rhee J, Puigserver P, Newgard CB, Spiegelman BM. PGC-1beta in the regulation of hepatic glucose and energy metabolism. The Journal of Biological Chemistry. 278: 30843-8. PMID 12807885 DOI: 10.1074/jbc.M303643200  0.84
2003 Handschin C, Rhee J, Lin J, Tarr PT, Spiegelman BM. An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle Proceedings of the National Academy of Sciences of the United States of America. 100: 7111-7116. PMID 12764228 DOI: 10.1073/pnas.1232352100  0.84
2003 Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 423: 550-5. PMID 12754525 DOI: 10.1038/nature01667  0.84
2003 St-Pierre J, Lin J, Krauss S, Tarr PT, Yang R, Newgard CB, Spiegelman BM. Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. The Journal of Biological Chemistry. 278: 26597-603. PMID 12734177 DOI: 10.1074/jbc.M301850200  0.84
2003 Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proceedings of the National Academy of Sciences of the United States of America. 100: 4012-7. PMID 12651943 DOI: 10.1073/pnas.0730870100  0.84
2003 Puigserver P, Spiegelman BM. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocrine Reviews. 24: 78-90. PMID 12588810 DOI: 10.1210/er.2002-0012  0.84
2003 Girnun GD, Spiegelman BM. PPARgamma ligands: taking Ppart in chemoprevention. Gastroenterology. 124: 564-7. PMID 12557160 DOI: 10.1053/gast.2003.50070  0.84
2003 Tritos NA, Mastaitis JW, Kokkotou EG, Puigserver P, Spiegelman BM, Maratos-Flier E. Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain. Brain Research. 961: 255-60. PMID 12531492 DOI: 10.1016/S0006-8993(02)03961-6  0.84
2002 Kulke MH, Demetri GD, Sharpless NE, Ryan DP, Shivdasani R, Clark JS, Spiegelman BM, Kim H, Mayer RJ, Fuchs CS. A phase II study of troglitazone, an activator of the PPARgamma receptor, in patients with chemotherapy-resistant metastatic colorectal cancer. Cancer Journal (Sudbury, Mass.). 8: 395-9. PMID 12416897 DOI: 10.1097/00130404-200209000-00010  0.84
2002 Girnun GD, Smith WM, Drori S, Sarraf P, Mueller E, Eng C, Nambiar P, Rosenberg DW, Bronson RT, Edelmann W, Kucherlapati R, Gonzalez FJ, Spiegelman BM. APC-dependent suppression of colon carcinogenesis by PPARgamma. Proceedings of the National Academy of Sciences of the United States of America. 99: 13771-6. PMID 12370429 DOI: 10.1073/pnas.162480299  0.84
2002 Mueller E, Drori S, Aiyer A, Yie J, Sarraf P, Chen H, Hauser S, Rosen ED, Ge K, Roeder RG, Spiegelman BM. Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor gamma isoforms. The Journal of Biological Chemistry. 277: 41925-30. PMID 12200443 DOI: 10.1074/jbc.M206950200  0.84
2002 Lin J, Wu H, Tarr PT, Zhang CY, Wu Z, Boss O, Michael LF, Puigserver P, Isotani E, Olson EN, Lowell BB, Bassel-Duby R, Spiegelman BM. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature. 418: 797-801. PMID 12181572 DOI: 10.1038/nature00904  0.84
2002 Ge K, Guermah M, Yuan CX, Ito M, Wallberg AE, Spiegelman BM, Roeder RG. Transcription coactivator TRAP220 is required for PPARγ2-stimulated adipogenesis Nature. 417: 563-567. PMID 12037571 DOI: 10.1038/417563a  0.84
2002 Spiegelman B. The perils of putting career before all else [2] Nature. 416: 365. PMID 11919598  0.84
2002 Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes & Development. 16: 22-6. PMID 11782441 DOI: 10.1101/gad.948702  0.84
2002 Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman BM. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. The Journal of Biological Chemistry. 277: 1645-8. PMID 11733490 DOI: 10.1074/jbc.C100631200  0.84
2001 Burstein HJ, Demetri GD, Shilo N, Mueller E, Spiegelman B, Winer EP. Phase II study of the PPARγ-activatingligand troglitazone in treatment-refractory metastatic breast cancer Breast Cancer Research and Treatment. 69: 304.  0.84
1997 Hotamisligil GS, Arner P, Atkinson RL, Spiegelman BM. Differential regulation of the p80 tumor necrosis factor receptor in human obesity and insulin resistance. Diabetes. 46: 451-5. PMID 9032102  0.84
1996 Hotamisligil GS, Johnson RS, Distel RJ, Ellis R, Papaioannou VE, Spiegelman BM. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Science (New York, N.Y.). 274: 1377-9. PMID 8910278 DOI: 10.1126/science.274.5291.1377  0.84
1996 Peraldi P, Hotamisligil GS, Buurman WA, White MF, Spiegelman BM. Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. The Journal of Biological Chemistry. 271: 13018-22. PMID 8662983  0.84
1996 Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science (New York, N.Y.). 271: 665-8. PMID 8571133  0.84
1995 Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. The Journal of Clinical Investigation. 95: 2409-15. PMID 7738205 DOI: 10.1172/JCI117936  0.84
1994 Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, Spiegelman BM. Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology. 134: 264-70. PMID 8275942 DOI: 10.1210/endo.134.1.8275942  0.84
1994 Hotamisligil GS, Murray DL, Choy LN, Spiegelman BM. Tumor necrosis factor alpha inhibits signaling from the insulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 91: 4854-8. PMID 8197147 DOI: 10.1073/pnas.91.11.4854  0.84
1994 Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes. 43: 1271-8. PMID 7926300  0.84
1994 Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. The Journal of Clinical Investigation. 94: 1543-9. PMID 7523453 DOI: 10.1172/JCI117495  0.84
1993 Spiegelman BM, Hotamisligil GS. Through thick and thin: wasting, obesity, and TNF alpha. Cell. 73: 625-7. PMID 8500160 DOI: 10.1016/0092-8674(93)90243-J  0.84
1993 Spiegelman BM, Choy L, Hotamisligil GS, Graves RA, Tontonoz P. Regulation of adipocyte gene expression in differentiation and syndromes of obesity/diabetes. The Journal of Biological Chemistry. 268: 6823-6. PMID 8463205  0.84
1993 Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (New York, N.Y.). 259: 87-91. PMID 7678183  0.84
1979 Spiegelman BM, Lopata MA, Kirschner MW. Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells. Cell. 16: 253-63. PMID 455435  0.92
1979 Spiegelman BM, Lopata MA, Kirschner MW. Multiple sites for the initiation of microtubule assembly in mammalian cells. Cell. 16: 239-52. PMID 455434  0.92
1979 Cleveland DW, Spiegelman BM, Kirschner MW. Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. The Journal of Biological Chemistry. 254: 12670-8. PMID 227904  0.92
1977 Spiegelman BM, Penningroth SM, Kirschner MW. Turnover of tubulin and the N site GTP in Chinese hamster ovary cells. Cell. 12: 587-600. PMID 562716 DOI: 10.1016/0092-8674(77)90259-8  0.84
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