Raymond J. Deshaies - Publications

2017 Biology California Institute of Technology, Pasadena, CA 
 2017- Global Research Amgen Inc., Thousand Oaks, CA, United States 
Ubiquitin-Dependent Proteolysis and Cell Division

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Year Citation  Score
2022 Cable J, Weber-Ban E, Clausen T, Walters KJ, Sharon M, Finley DJ, Gu Y, Hanna J, Feng Y, Martens S, Simonsen A, Hansen M, Zhang H, Goodwin JM, Reggio A, ... ... Deshaies RJ, et al. Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report. Annals of the New York Academy of Sciences. PMID 35000205 DOI: 10.1111/nyas.14745  0.382
2021 Porras-Yakushi TR, Reitsma JM, Sweredoski MJ, Deshaies RJ, Hess S. In-depth proteomic analysis of proteasome inhibitors bortezomib, carfilzomib and MG132 reveals that mortality factor 4-like 1 (MORF4L1) protein ubiquitylation is negatively impacted. Journal of Proteomics. 241: 104197. PMID 33848640 DOI: 10.1016/j.jprot.2021.104197  0.334
2020 Yang SJ, Jeon SJ, Van Nguyen T, Deshaies RJ, Park CS, Lee KM. Ubiquitin-dependent proteasomal degradation of AMPK gamma subunit by Cereblon inhibits AMPK activity. Biochimica Et Biophysica Acta. Molecular Cell Research. 118729. PMID 32333926 DOI: 10.1016/J.Bbamcr.2020.118729  0.492
2020 Deshaies RJ, Pierce NW. Transfer of ubiquitin protein caught in the act. Nature. 578: 372-373. PMID 32066917 DOI: 10.1038/D41586-020-00325-9  0.46
2020 Verma R, Mohl D, Deshaies RJ. Harnessing the Power of Proteolysis for Targeted Protein Inactivation. Molecular Cell. PMID 32004468 DOI: 10.1016/J.Molcel.2020.01.010  0.439
2020 Reichermeier KM, Straube R, Reitsma JM, Sweredoski MJ, Rose CM, Moradian A, den Besten W, Hinkle T, Verschueren E, Petzold G, Thomä NH, Wertz IE, Deshaies RJ, Kirkpatrick DS. PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network. Molecular Cell. PMID 31973889 DOI: 10.1016/J.Molcel.2019.12.013  0.44
2020 Wang K, Deshaies RJ, Liu X. Assembly and Regulation of CRL Ubiquitin Ligases. Advances in Experimental Medicine and Biology. 1217: 33-46. PMID 31898220 DOI: 10.1007/978-981-15-1025-0_3  0.514
2019 Blythe EE, Gates SN, Deshaies RJ, Martin A. Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing. Structure (London, England : 1993). PMID 31623962 DOI: 10.1016/J.Str.2019.09.011  0.398
2018 Li J, Zhang Y, Da Silva Sil Dos Santos B, Wang F, Ma Y, Perez C, Yang Y, Peng J, Cohen SM, Chou TF, Hilton ST, Deshaies RJ. Epidithiodiketopiperazines Inhibit Protein Degradation by Targeting Proteasome Deubiquitinase Rpn11. Cell Chemical Biology. PMID 30146242 DOI: 10.1016/J.Chembiol.2018.07.012  0.499
2018 Lobanova ES, Finkelstein S, Li J, Travis AM, Hao Y, Klingeborn M, Skiba NP, Deshaies RJ, Arshavsky VY. Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration. Nature Communications. 9: 1738. PMID 29712894 DOI: 10.1038/S41467-018-04117-8  0.32
2018 Verma R, Reichermeier KM, Burroughs AM, Oania RS, Reitsma JM, Aravind L, Deshaies RJ. Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes. Nature. PMID 29632312 DOI: 10.1038/S41586-018-0022-5  0.393
2018 Liu X, Reitsma JM, Mamrosh JL, Zhang Y, Straube R, Deshaies RJ. Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression. Molecular Cell. 69: 773-786.e6. PMID 29499133 DOI: 10.1016/J.Molcel.2018.01.038  0.447
2017 Nakasone MA, Lewis TA, Walker O, Thakur A, Mansour W, Castañeda CA, Goeckeler-Fried JL, Parlati F, Chou TF, Hayat O, Zhang D, Camara CM, Bonn SM, Nowicka UK, Krueger S, ... ... Deshaies RJ, et al. Structural Basis for the Inhibitory Effects of Ubistatins in the Ubiquitin-Proteasome Pathway. Structure (London, England : 1993). PMID 29153505 DOI: 10.1016/J.Str.2017.10.007  0.583
2017 Reitsma JM, Liu X, Reichermeier KM, Moradian A, Sweredoski MJ, Hess S, Deshaies RJ. Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases. Cell. PMID 29103612 DOI: 10.1016/J.Cell.2017.10.016  0.44
2017 Blythe EE, Olson KC, Chau V, Deshaies RJ. Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy. Proceedings of the National Academy of Sciences of the United States of America. PMID 28512218 DOI: 10.1073/Pnas.1706205114  0.406
2017 Lauinger L, Li J, Shostak A, Cemel IA, Ha N, Zhang Y, Merkl PE, Obermeyer S, Stankovic-Valentin N, Schafmeier T, Wever WJ, Bowers AA, Carter KP, Palmer AE, Tschochner H, ... ... Deshaies RJ, et al. Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases. Nature Chemical Biology. PMID 28459440 DOI: 10.1038/Nchembio.2370  0.408
2017 Perez C, Li J, Parlati F, Rouffet M, Ma Y, Zhou HJ, Mackinnon AL, Chou TF, Deshaies RJ, Cohen SM. Correction to Discovery of an Inhibitor of the Proteasome Subunit Rpn11. Journal of Medicinal Chemistry. PMID 28328205 DOI: 10.1021/Acs.Jmedchem.7B00390  0.344
2017 Nguyen TV, Li J, Lu CJ, Mamrosh JL, Lu G, Cathers BE, Deshaies RJ. p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates. Proceedings of the National Academy of Sciences of the United States of America. PMID 28320958 DOI: 10.1073/Pnas.1700949114  0.472
2017 Li J, Yakushi T, Parlati F, Mackinnon AL, Perez C, Ma Y, Carter KP, Colayco S, Magnuson G, Brown B, Nguyen K, Vasile S, Suyama E, Smith LH, Sergienko E, ... ... Deshaies RJ, et al. Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11. Nature Chemical Biology. PMID 28244987 DOI: 10.1038/Nchembio.2326  0.401
2017 Perez C, Li J, Parlati F, Rouffet M, Ma Y, Mackinnon AL, Chou TF, Deshaies RJ, Cohen SM. Discovery of an Inhibitor of the Proteasome Subunit Rpn11. Journal of Medicinal Chemistry. PMID 28191850 DOI: 10.1021/Acs.Jmedchem.6B01379  0.435
2016 Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H. The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function. The Embo Journal. PMID 28007894 DOI: 10.15252/Embj.201694795  0.475
2016 Vangala JR, Sotzny F, Krüger E, Deshaies RJ, Radhakrishnan SK. Nrf1 can be processed and activated in a proteasome-independent manner. Current Biology : Cb. 26: R834-R835. PMID 27676297 DOI: 10.1016/J.Cub.2016.08.008  0.409
2016 Kleiger G, Deshaies R. Tag Team Ubiquitin Ligases. Cell. 166: 1080-1. PMID 27565338 DOI: 10.1016/J.Cell.2016.08.014  0.312
2016 Sung MK, Porras-Yakushi TR, Reitsma JM, Huber FM, Sweredoski MJ, Hoelz A, Hess S, Deshaies RJ. A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins. Elife. 5. PMID 27552055 DOI: 10.7554/Elife.19105  0.476
2016 Xue L, Blythe EE, Freiberger EC, Mamrosh J, Hebert AS, Reitsma JM, Hess S, Coon JJ, Deshaies RJ. VCP-adaptor interactions are exceptionally dynamic and subject to differential modulation by a VCP inhibitor. Molecular & Cellular Proteomics : McP. PMID 27406709 DOI: 10.1074/Mcp.M116.061036  0.426
2016 Sung MK, Reitsma JM, Sweredoski MJ, Hess S, Deshaies RJ. Ribosomal proteins produced in excess are degraded by the ubiquitin-proteasome system. Molecular Biology of the Cell. PMID 27385339 DOI: 10.1091/Mbc.E16-05-0290  0.503
2016 Mosadeghi R, Reichermeier KM, Winkler M, Schreiber A, Reitsma JM, Zhang Y, Stengel F, Cao J, Kim M, Sweredoski MJ, Hess S, Leitner A, Aebersold R, Peter M, Deshaies RJ, et al. Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle. Elife. 5. PMID 27031283 DOI: 10.7554/Elife.12102  0.4
2016 Nguyen TV, Lee JE, Sweredoski MJ, Yang SJ, Jeon SJ, Harrison JS, Yim JH, Lee SG, Handa H, Kuhlman B, Jeong JS, Reitsma JM, Park CS, Hess S, Deshaies RJ. Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon. Molecular Cell. 61: 809-820. PMID 26990986 DOI: 10.1016/J.Molcel.2016.02.032  0.656
2016 Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. Acs Medicinal Chemistry Letters. 7: 182-7. PMID 26985295 DOI: 10.1021/Acsmedchemlett.5B00396  0.363
2016 Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, et al. 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science (New York, N.Y.). PMID 26822609 DOI: 10.1126/Science.Aad7974  0.308
2016 Sung M, Porras-Yakushi TR, Reitsma JM, Huber FM, Sweredoski MJ, Hoelz A, Hess S, Deshaies RJ. Author response: A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins Elife. DOI: 10.7554/Elife.19105.026  0.374
2016 Mosadeghi R, Reichermeier KM, Winkler M, Schreiber A, Reitsma JM, Zhang Y, Stengel F, Cao J, Kim M, Sweredoski MJ, Hess S, Leitner A, Aebersold R, Peter M, Deshaies RJ, et al. Author response: Structural and kinetic analysis of the COP9-Signalosome activation and the cullin-RING ubiquitin ligase deneddylation cycle Elife. DOI: 10.7554/Elife.12102.031  0.311
2015 Deshaies RJ. Corrigendum: Protein degradation: Prime time for PROTACs. Nature Chemical Biology. 11: 887. PMID 26485081 DOI: 10.1038/Nchembio1115-887B  0.404
2015 Deshaies RJ. Protein degradation: Prime time for PROTACs. Nature Chemical Biology. 11: 634-5. PMID 26284668 DOI: 10.1038/Nchembio.1887  0.416
2015 Pulvino M, Chen L, Oleksyn D, Li J, Compitello G, Rossi R, Spence S, Balakrishnan V, Jordan C, Poligone B, Casulo C, Burack R, Shapiro JL, Bernstein S, Friedberg JW, ... Deshaies RJ, et al. Inhibition of COP9-signalosome (CSN) deneddylating activity and tumor growth of diffuse large B-cell lymphomas by doxycycline. Oncotarget. 6: 14796-813. PMID 26142707 DOI: 10.18632/Oncotarget.4193  0.314
2014 Deshaies RJ. Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy. Bmc Biology. 12: 94. PMID 25385277 DOI: 10.1186/S12915-014-0094-0  0.362
2014 Fang NN, Chan GT, Zhu M, Comyn SA, Persaud A, Deshaies RJ, Rotin D, Gsponer J, Mayor T. Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress. Nature Cell Biology. 16: 1227-37. PMID 25344756 DOI: 10.1038/Ncb3054  0.353
2014 Deshaies RJ. Structural biology: Corralling a protein-degradation regulator. Nature. 512: 145-6. PMID 25043034 DOI: 10.1038/Nature13644  0.478
2014 Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. Journal of Molecular Biology. 426: 2886-99. PMID 24878061 DOI: 10.1016/J.Jmb.2014.05.022  0.354
2014 Chan NC, den Besten W, Sweredoski MJ, Hess S, Deshaies RJ, Chan DC. Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2. The Journal of Biological Chemistry. 289: 19789-98. PMID 24855649 DOI: 10.1074/Jbc.M114.569392  0.426
2014 Radhakrishnan SK, den Besten W, Deshaies RJ. p97-dependent retrotranslocation and proteolytic processing govern formation of active Nrf1 upon proteasome inhibition. Elife. 3: e01856. PMID 24448410 DOI: 10.7554/Elife.01856  0.331
2014 Honarpour N, Rose CM, Brumbaugh J, Anderson J, Graham RL, Sweredoski MJ, Hess S, Coon JJ, Deshaies RJ. F-box protein FBXL16 binds PP2A-B55α and regulates differentiation of embryonic stem cells along the FLK1+ lineage. Molecular & Cellular Proteomics : McP. 13: 780-91. PMID 24390425 DOI: 10.1074/Mcp.M113.031765  0.416
2013 Kolawa N, Sweredoski MJ, Graham RL, Oania R, Hess S, Deshaies RJ. Perturbations to the ubiquitin conjugate proteome in yeast δubx mutants identify Ubx2 as a regulator of membrane lipid composition. Molecular & Cellular Proteomics : McP. 12: 2791-803. PMID 23793018 DOI: 10.1074/Mcp.M113.030163  0.836
2013 Kurimchak A, Haines DS, Garriga J, Wu S, De Luca F, Sweredoski MJ, Deshaies RJ, Hess S, Graña X. Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme. Molecular and Cellular Biology. 33: 3330-42. PMID 23775125 DOI: 10.1128/Mcb.00082-13  0.411
2013 Pierce NW, Lee JE, Liu X, Sweredoski MJ, Graham RL, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S, Shan SO, Deshaies RJ. Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins. Cell. 153: 206-15. PMID 23453757 DOI: 10.1016/J.Cell.2013.02.024  0.465
2013 Verma R, Oania RS, Kolawa NJ, Deshaies RJ. Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome. Elife. 2: e00308. PMID 23358411 DOI: 10.7554/Elife.00308  0.782
2013 Chou TF, Li K, Frankowski KJ, Schoenen FJ, Deshaies RJ. Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase. Chemmedchem. 8: 297-312. PMID 23316025 DOI: 10.1002/Cmdc.201200520  0.373
2013 Shi Y, Liu X, Calaoagan J, Samuelsson S, Chou T, Deshaies RJ, Sambucetti LC. Abstract 2146: Development of functional assays for p97/VCP inhibition. Cancer Research. 73: 2146-2146. DOI: 10.1158/1538-7445.Am2013-2146  0.39
2012 Emberley ED, Mosadeghi R, Deshaies RJ. Deconjugation of Nedd8 from Cul1 is directly regulated by Skp1-F-box and substrate, and the COP9 signalosome inhibits deneddylated SCF by a noncatalytic mechanism. The Journal of Biological Chemistry. 287: 29679-89. PMID 22767593 DOI: 10.1074/Jbc.M112.352484  0.423
2012 Oh Y, Chang KJ, Orlean P, Wloka C, Deshaies R, Bi E. Mitotic exit kinase Dbf2 directly phosphorylates chitin synthase Chs2 to regulate cytokinesis in budding yeast. Molecular Biology of the Cell. 23: 2445-56. PMID 22573892 DOI: 10.1091/Mbc.E12-01-0033  0.489
2012 den Besten W, Verma R, Kleiger G, Oania RS, Deshaies RJ. NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway. Nature Structural & Molecular Biology. 19: 511-6, S1. PMID 22466964 DOI: 10.1038/Nsmb.2269  0.473
2012 Sohn CH, Agnew HD, Lee JE, Sweredoski MJ, Graham RL, Smith GT, Hess S, Czerwieniec G, Loo JA, Heath JR, Deshaies RJ, Beauchamp JL. Designer reagents for mass spectrometry-based proteomics: clickable cross-linkers for elucidation of protein structures and interactions. Analytical Chemistry. 84: 2662-9. PMID 22339618 DOI: 10.1021/Ac202637N  0.349
2012 Haines DS, Lee JE, Beauparlant SL, Kyle DB, den Besten W, Sweredoski MJ, Graham RL, Hess S, Deshaies RJ. Protein interaction profiling of the p97 adaptor UBXD1 points to a role for the complex in modulating ERGIC-53 trafficking. Molecular & Cellular Proteomics : McP. 11: M111.016444. PMID 22337587 DOI: 10.1074/Mcp.M111.016444  0.504
2012 Verma R, Oania RS, Kolawa NJ, Deshaies RJ. Author response: Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome Elife. DOI: 10.7554/Elife.00308.018  0.335
2011 Rabut G, Le Dez G, Verma R, Makhnevych T, Knebel A, Kurz T, Boone C, Deshaies RJ, Peter M. The TFIIH subunit Tfb3 regulates cullin neddylation. Molecular Cell. 43: 488-95. PMID 21816351 DOI: 10.1016/J.Molcel.2011.05.032  0.505
2011 Gomez TA, Kolawa N, Gee M, Sweredoski MJ, Deshaies RJ. Identification of a functional docking site in the Rpn1 LRR domain for the UBA-UBL domain protein Ddi1. Bmc Biology. 9: 33. PMID 21627799 DOI: 10.1186/1741-7007-9-33  0.824
2011 Chou TF, Deshaies RJ. Development of p97 AAA ATPase inhibitors. Autophagy. 7: 1091-2. PMID 21606684 DOI: 10.4161/Auto.7.9.16489  0.39
2011 Saha A, Lewis S, Kleiger G, Kuhlman B, Deshaies RJ. Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate. Molecular Cell. 42: 75-83. PMID 21474069 DOI: 10.1016/J.Molcel.2011.03.016  0.621
2011 Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ. Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways. Proceedings of the National Academy of Sciences of the United States of America. 108: 4834-9. PMID 21383145 DOI: 10.1073/Pnas.1015312108  0.393
2011 Chou TF, Deshaies RJ. Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system. The Journal of Biological Chemistry. 286: 16546-54. PMID 21343295 DOI: 10.1074/Jbc.M110.215319  0.465
2011 Verma R, Oania R, Fang R, Smith GT, Deshaies RJ. Cdc48/p97 mediates UV-dependent turnover of RNA Pol II. Molecular Cell. 41: 82-92. PMID 21211725 DOI: 10.1016/J.Molcel.2010.12.017  0.515
2011 Lee JE, Sweredoski MJ, Graham RL, Kolawa NJ, Smith GT, Hess S, Deshaies RJ. The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation. Molecular & Cellular Proteomics : McP. 10: M110.006460. PMID 21169563 DOI: 10.1074/Mcp.M110.006460  0.821
2010 Deshaies RJ, Emberley ED, Saha A. Control of cullin-ring ubiquitin ligase activity by nedd8. Sub-Cellular Biochemistry. 54: 41-56. PMID 21222272 DOI: 10.1007/978-1-4419-6676-6_4  0.486
2010 Tyrrell A, Flick K, Kleiger G, Zhang H, Deshaies RJ, Kaiser P. Physiologically relevant and portable tandem ubiquitin-binding domain stabilizes polyubiquitylated proteins. Proceedings of the National Academy of Sciences of the United States of America. 107: 19796-801. PMID 21041680 DOI: 10.1073/Pnas.1010648107  0.491
2010 Collins GA, Gomez TA, Deshaies RJ, Tansey WP. Combined chemical and genetic approach to inhibit proteolysis by the proteasome. Yeast (Chichester, England). 27: 965-74. PMID 20625982 DOI: 10.1002/Yea.1805  0.431
2010 Aghajan M, Jonai N, Flick K, Fu F, Luo M, Cai X, Ouni I, Pierce N, Tang X, Lomenick B, Damoiseaux R, Hao R, Del Moral PM, Verma R, Li Y, ... ... Deshaies RJ, et al. Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase. Nature Biotechnology. 28: 738-42. PMID 20581845 DOI: 10.1038/Nbt.1645  0.438
2010 Radhakrishnan SK, Lee CS, Young P, Beskow A, Chan JY, Deshaies RJ. Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Molecular Cell. 38: 17-28. PMID 20385086 DOI: 10.1016/J.Molcel.2010.02.029  0.381
2009 Pierce NW, Kleiger G, Shan SO, Deshaies RJ. Detection of sequential polyubiquitylation on a millisecond timescale. Nature. 462: 615-9. PMID 19956254 DOI: 10.1038/Nature08595  0.348
2009 Kleiger G, Saha A, Lewis S, Kuhlman B, Deshaies RJ. Rapid E2-E3 assembly and disassembly enable processive ubiquitylation of cullin-RING ubiquitin ligase substrates. Cell. 139: 957-68. PMID 19945379 DOI: 10.1016/J.Cell.2009.10.030  0.637
2009 Kleiger G, Hao B, Mohl DA, Deshaies RJ. The acidic tail of the Cdc34 ubiquitin-conjugating enzyme functions in both binding to and catalysis with ubiquitin ligase SCFCdc4. The Journal of Biological Chemistry. 284: 36012-23. PMID 19875449 DOI: 10.1074/Jbc.M109.058529  0.455
2009 Collins GA, Lipford JR, Deshaies RJ, Tansey WP. Gal4 turnover and transcription activation. Nature. 461: E7; discussion E8. PMID 19812621 DOI: 10.1038/Nature08406  0.335
2009 Deshaies RJ, Joazeiro CA. RING domain E3 ubiquitin ligases. Annual Review of Biochemistry. 78: 399-434. PMID 19489725 DOI: 10.1146/Annurev.Biochem.78.101807.093809  0.419
2009 Mohl DA, Huddleston MJ, Collingwood TS, Annan RS, Deshaies RJ. Dbf2-Mob1 drives relocalization of protein phosphatase Cdc14 to the cytoplasm during exit from mitosis. The Journal of Cell Biology. 184: 527-39. PMID 19221193 DOI: 10.1083/Jcb.200812022  0.495
2009 Oh YM, Kwon YE, Kim JM, Bae SJ, Lee BK, Yoo SJ, Chung CH, Deshaies RJ, Seol JH. Chfr is linked to tumour metastasis through the downregulation of HDAC1. Nature Cell Biology. 11: 295-302. PMID 19182791 DOI: 10.1038/Ncb1837  0.433
2008 Saha A, Deshaies RJ. Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Molecular Cell. 32: 21-31. PMID 18851830 DOI: 10.1016/J.Molcel.2008.08.021  0.468
2008 Rodriguez-Gonzalez A, Cyrus K, Salcius M, Kim K, Crews CM, Deshaies RJ, Sakamoto KM. Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer. Oncogene. 27: 7201-11. PMID 18794799 DOI: 10.1038/Onc.2008.320  0.572
2008 Alexandru G, Graumann J, Smith GT, Kolawa NJ, Fang R, Deshaies RJ. UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. Cell. 134: 804-16. PMID 18775313 DOI: 10.1016/J.Cell.2008.06.048  0.809
2008 Goh AM, Walters KJ, Elsasser S, Verma R, Deshaies RJ, Finley D, Howley PM. Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. Bmc Biochemistry. 9: 4. PMID 18234089 DOI: 10.1186/1471-2091-9-4  0.48
2008 Haririnia A, Verma R, Purohit N, Twarog MZ, Deshaies RJ, Bolon D, Fushman D. Mutations in the hydrophobic core of ubiquitin differentially affect its recognition by receptor proteins. Journal of Molecular Biology. 375: 979-96. PMID 18054791 DOI: 10.1016/J.Jmb.2007.11.016  0.48
2008 Sakamoto K, Rodriguez-Gonzalez A, Cyrus K, Kim K, Crews C, Deshaies R. 39 INVITED Targeting steroid hormone receptors for ubiquitination and degradation in breast and prostate cancer European Journal of Cancer Supplements. 6: 16. DOI: 10.1016/S1359-6349(08)71971-2  0.506
2007 Mayor T, Graumann J, Bryan J, MacCoss MJ, Deshaies RJ. Quantitative profiling of ubiquitylated proteins reveals proteasome substrates and the substrate repertoire influenced by the Rpn10 receptor pathway. Molecular & Cellular Proteomics : McP. 6: 1885-95. PMID 17644757 DOI: 10.1074/Mcp.M700264-Mcp200  0.706
2007 Ghaboosi N, Deshaies RJ. A conditional yeast E1 mutant blocks the ubiquitin-proteasome pathway and reveals a role for ubiquitin conjugates in targeting Rad23 to the proteasome. Molecular Biology of the Cell. 18: 1953-63. PMID 17360968 DOI: 10.1091/Mbc.E06-10-0965  0.83
2006 Petroski MD, Kleiger G, Deshaies RJ. Evaluation of a diffusion-driven mechanism for substrate ubiquitination by the SCF-Cdc34 ubiquitin ligase complex. Molecular Cell. 24: 523-34. PMID 17114057 DOI: 10.1016/J.Molcel.2006.10.010  0.441
2006 Sharon M, Taverner T, Ambroggio XI, Deshaies RJ, Robinson CV. Structural organization of the 19S proteasome lid: insights from MS of intact complexes. Plos Biology. 4: e267. PMID 16869714 DOI: 10.1371/Journal.Pbio.0040267  0.743
2006 Cope GA, Deshaies RJ. Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels. Bmc Biochemistry. 7: 1. PMID 16401342 DOI: 10.1186/1471-2091-7-1  0.494
2005 Petroski MD, Deshaies RJ. Mechanism of lysine 48-linked ubiquitin-chain synthesis by the cullin-RING ubiquitin-ligase complex SCF-Cdc34. Cell. 123: 1107-20. PMID 16360039 DOI: 10.1016/J.Cell.2005.09.033  0.429
2005 Mayor T, Deshaies RJ. Two-step affinity purification of multiubiquitylated proteins from Saccharomyces cerevisiae. Methods in Enzymology. 399: 385-92. PMID 16338370 DOI: 10.1016/S0076-6879(05)99026-5  0.494
2005 Verma R, Deshaies RJ. Assaying degradation and deubiquitination of a ubiquitinated substrate by purified 26S proteasomes. Methods in Enzymology. 398: 391-9. PMID 16275345 DOI: 10.1016/S0076-6879(05)98032-4  0.522
2005 Petroski MD, Deshaies RJ. In vitro reconstitution of SCF substrate ubiquitination with purified proteins. Methods in Enzymology. 398: 143-58. PMID 16275326 DOI: 10.1016/S0076-6879(05)98013-0  0.54
2005 Lipford JR, Smith GT, Chi Y, Deshaies RJ. A putative stimulatory role for activator turnover in gene expression. Nature. 438: 113-6. PMID 16267558 DOI: 10.1038/Nature04098  0.601
2005 Mah AS, Elia AE, Devgan G, Ptacek J, Schutkowski M, Snyder M, Yaffe MB, Deshaies RJ. Substrate specificity analysis of protein kinase complex Dbf2-Mob1 by peptide library and proteome array screening. Bmc Biochemistry. 6: 22. PMID 16242037 DOI: 10.1186/1471-2091-6-22  0.808
2005 Mayor T, Lipford JR, Graumann J, Smith GT, Deshaies RJ. Analysis of polyubiquitin conjugates reveals that the Rpn10 substrate receptor contributes to the turnover of multiple proteasome targets. Molecular & Cellular Proteomics : McP. 4: 741-51. PMID 15699485 DOI: 10.1074/Mcp.M400220-Mcp200  0.738
2005 Petroski MD, Deshaies RJ. Function and regulation of cullin-RING ubiquitin ligases. Nature Reviews. Molecular Cell Biology. 6: 9-20. PMID 15688063 DOI: 10.1038/Nrm1547  0.438
2004 Baumeister W, Bachmair A, Chau V, Cohen R, Coffino P, Demartino G, Deshaies R, Dohmen J, Emr S, Finley D, Hampton R, Hill C, Hochstrasser M, Huber R, Jackson P, et al. Varshavsky's contributions. Science (New York, N.Y.). 306: 1290-2. PMID 15550643 DOI: 10.1126/Science.306.5700.1290  0.691
2004 Verma R, Peters NR, D'Onofrio M, Tochtrop GP, Sakamoto KM, Varadan R, Zhang M, Coffino P, Fushman D, Deshaies RJ, King RW. Ubistatins inhibit proteasome-dependent degradation by binding the ubiquitin chain. Science (New York, N.Y.). 306: 117-20. PMID 15459393 DOI: 10.1126/Science.1100946  0.742
2004 Azzam R, Chen SL, Shou W, Mah AS, Alexandru G, Nasmyth K, Annan RS, Carr SA, Deshaies RJ. Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus. Science (New York, N.Y.). 305: 516-9. PMID 15273393 DOI: 10.1126/Science.1099402  0.776
2004 Verma R, Oania R, Graumann J, Deshaies RJ. Multiubiquitin chain receptors define a layer of substrate selectivity in the ubiquitin-proteasome system. Cell. 118: 99-110. PMID 15242647 DOI: 10.1016/J.Cell.2004.06.014  0.712
2004 Schneekloth JS, Fonseca FN, Koldobskiy M, Mandal A, Deshaies R, Sakamoto K, Crews CM. Chemical genetic control of protein levels: selective in vivo targeted degradation. Journal of the American Chemical Society. 126: 3748-54. PMID 15038727 DOI: 10.1021/Ja039025Z  0.634
2004 Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM. Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase. Science (New York, N.Y.). 303: 1371-4. PMID 14739464 DOI: 10.1126/Science.1093549  0.431
2004 Ambroggio XI, Rees DC, Deshaies RJ. JAMM: a metalloprotease-like zinc site in the proteasome and signalosome. Plos Biology. 2: E2. PMID 14737182 DOI: 10.1371/Journal.Pbio.0020002  0.775
2004 Graumann J, Dunipace LA, Seol JH, McDonald WH, Yates JR, Wold BJ, Deshaies RJ. Applicability of tandem affinity purification MudPIT to pathway proteomics in yeast. Molecular & Cellular Proteomics : McP. 3: 226-37. PMID 14660704 DOI: 10.1074/Mcp.M300099-Mcp200  0.711
2003 Sakamoto KM, Kim KB, Verma R, Ransick A, Stein B, Crews CM, Deshaies RJ. Development of Protacs to target cancer-promoting proteins for ubiquitination and degradation. Molecular & Cellular Proteomics : McP. 2: 1350-8. PMID 14525958 DOI: 10.1074/Mcp.T300009-Mcp200  0.633
2003 Lipford JR, Deshaies RJ. Diverse roles for ubiquitin-dependent proteolysis in transcriptional activation. Nature Cell Biology. 5: 845-50. PMID 14523392 DOI: 10.1038/Ncb1003-845  0.369
2003 Cope GA, Deshaies RJ. COP9 signalosome: a multifunctional regulator of SCF and other cullin-based ubiquitin ligases. Cell. 114: 663-71. PMID 14505567 DOI: 10.1016/S0092-8674(03)00722-0  0.457
2003 Petroski MD, Deshaies RJ. Redundant degrons ensure the rapid destruction of Sic1 at the G1/S transition of the budding yeast cell cycle. Cell Cycle (Georgetown, Tex.). 2: 410-1. PMID 12963827 DOI: 10.4161/Cc.2.5.489  0.305
2003 Petroski MD, Deshaies RJ. Context of multiubiquitin chain attachment influences the rate of Sic1 degradation. Molecular Cell. 11: 1435-44. PMID 12820958 DOI: 10.1016/S1097-2765(03)00221-1  0.435
2003 Park CJ, Song S, Lee PR, Shou W, Deshaies RJ, Lee KS. Loss of CDC5 function in Saccharomyces cerevisiae leads to defects in Swe1p regulation and Bfa1p/Bub2p-independent cytokinesis. Genetics. 163: 21-33. PMID 12586693  0.566
2002 Cope GA, Suh GS, Aravind L, Schwarz SE, Zipursky SL, Koonin EV, Deshaies RJ. Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1. Science (New York, N.Y.). 298: 608-11. PMID 12183637 DOI: 10.1126/Science.1075901  0.503
2002 Verma R, Aravind L, Oania R, McDonald WH, Yates JR, Koonin EV, Deshaies RJ. Role of Rpn11 metalloprotease in deubiquitination and degradation by the 26S proteasome. Science (New York, N.Y.). 298: 611-5. PMID 12183636 DOI: 10.1126/Science.1075898  0.489
2002 Deshaies RJ, Seol JH, McDonald WH, Cope G, Lyapina S, Shevchenko A, Shevchenko A, Verma R, Yates JR. Charting the protein complexome in yeast by mass spectrometry. Molecular & Cellular Proteomics : McP. 1: 3-10. PMID 12096135 DOI: 10.1074/Mcp.R100001-Mcp200  0.816
2002 Loughrey Chen S, Huddleston MJ, Shou W, Deshaies RJ, Annan RS, Carr SA. Mass spectrometry-based methods for phosphorylation site mapping of hyperphosphorylated proteins applied to Net1, a regulator of exit from mitosis in yeast. Molecular & Cellular Proteomics : McP. 1: 186-96. PMID 12096118 DOI: 10.1074/Mcp.M100032-Mcp200  0.648
2002 Shou W, Verma R, Annan RS, Huddleston MJ, Chen SL, Carr SA, Deshaies RJ. Mapping phosphorylation sites in proteins by mass spectrometry. Methods in Enzymology. 351: 279-96. PMID 12073350 DOI: 10.1016/S0076-6879(02)51853-X  0.604
2002 Shou W, Azzam R, Chen SL, Huddleston MJ, Baskerville C, Charbonneau H, Annan RS, Carr SA, Deshaies RJ. Cdc5 influences phosphorylation of Net1 and disassembly of the RENT complex. Bmc Molecular Biology. 3: 3. PMID 11960554 DOI: 10.1186/1471-2199-3-3  0.812
2002 Shou W, Deshaies RJ. Multiple telophase arrest bypassed (tab) mutants alleviate the essential requirement for Cdc15 in exit from mitosis in S. cerevisiae. Bmc Genetics. 3: 4. PMID 11914130 DOI: 10.1186/1471-2156-3-4  0.625
2001 Deshaies RJ, Ferrell JE. Multisite phosphorylation and the countdown to S phase. Cell. 107: 819-22. PMID 11779457 DOI: 10.1016/S0092-8674(01)00620-1  0.418
2001 Wu G, Lyapina S, Das I, Li J, Gurney M, Pauley A, Chui I, Deshaies RJ, Kitajewski J. SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Molecular and Cellular Biology. 21: 7403-15. PMID 11585921 DOI: 10.1128/Mcb.21.21.7403-7415.2001  0.81
2001 Verma R, McDonald H, Yates JR, Deshaies RJ. Selective degradation of ubiquitinated Sic1 by purified 26S proteasome yields active S phase cyclin-Cdk. Molecular Cell. 8: 439-48. PMID 11545745 DOI: 10.1016/S1097-2765(01)00308-2  0.487
2001 Shou W, Sakamoto KM, Keener J, Morimoto KW, Traverso EE, Azzam R, Hoppe GJ, Feldman RM, DeModena J, Moazed D, Charbonneau H, Nomura M, Deshaies RJ. Net1 stimulates RNA polymerase I transcription and regulates nucleolar structure independently of controlling mitotic exit. Molecular Cell. 8: 45-55. PMID 11511359 DOI: 10.1016/S1097-2765(01)00291-X  0.797
2001 Zhou C, Seibert V, Geyer R, Rhee E, Lyapina S, Cope G, Deshaies RJ, Wolf DA. The fission yeast COP9/signalosome is involved in cullin modification by ubiquitin-related Ned8p. Bmc Biochemistry. 2: 7. PMID 11504566 DOI: 10.1186/1471-2091-2-7  0.836
2001 Sakamoto KM, Kim KB, Kumagai A, Mercurio F, Crews CM, Deshaies RJ. Protacs: chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation. Proceedings of the National Academy of Sciences of the United States of America. 98: 8554-9. PMID 11438690 DOI: 10.1073/Pnas.141230798  0.669
2001 Mah AS, Jang J, Deshaies RJ. Protein kinase Cdc15 activates the Dbf2-Mob1 kinase complex. Proceedings of the National Academy of Sciences of the United States of America. 98: 7325-30. PMID 11404483 DOI: 10.1073/Pnas.141098998  0.816
2001 Lyapina S, Cope G, Shevchenko A, Serino G, Tsuge T, Zhou C, Wolf DA, Wei N, Shevchenko A, Deshaies RJ. Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome. Science (New York, N.Y.). 292: 1382-5. PMID 11337588 DOI: 10.1126/Science.1059780  0.843
2001 Schwechheimer C, Serino G, Callis J, Crosby WL, Lyapina S, Deshaies RJ, Gray WM, Estelle M, Deng XW. Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science (New York, N.Y.). 292: 1379-82. PMID 11337587 DOI: 10.1126/Science.1059776  0.797
2001 Chi Y, Huddleston MJ, Zhang X, Young RA, Annan RS, Carr SA, Deshaies RJ. Negative regulation of Gcn4 and Msn2 transcription factors by Srb10 cyclin-dependent kinase. Genes & Development. 15: 1078-92. PMID 11331604 DOI: 10.1101/Gad.867501  0.633
2001 Galan JM, Wiederkehr A, Seol JH, Haguenauer-Tsapis R, Deshaies RJ, Riezman H, Peter M. Skp1p and the F-box protein Rcy1p form a non-SCF complex involved in recycling of the SNARE Snc1p in yeast. Molecular and Cellular Biology. 21: 3105-17. PMID 11287615 DOI: 10.1128/Mcb.21.9.3105-3117.2001  0.43
2001 Seol JH, Shevchenko A, Shevchenko A, Deshaies RJ. Skp1 forms multiple protein complexes, including RAVE, a regulator of V-ATPase assembly. Nature Cell Biology. 3: 384-91. PMID 11283612 DOI: 10.1038/35070067  0.469
2001 Traverso EE, Baskerville C, Liu Y, Shou W, James P, Deshaies RJ, Charbonneau H. Characterization of the Net1 cell cycle-dependent regulator of the Cdc14 phosphatase from budding yeast. The Journal of Biological Chemistry. 276: 21924-31. PMID 11274204 DOI: 10.1074/Jbc.M011689200  0.656
2001 Lippincott J, Shannon KB, Shou W, Deshaies RJ, Li R. The Tem1 small GTPase controls actomyosin and septin dynamics during cytokinesis. Journal of Cell Science. 114: 1379-86. PMID 11257003  0.503
2001 Annan RS, Huddleston MJ, Verma R, Deshaies RJ, Carr SA. A multidimensional electrospray MS-based approach to phosphopeptide mapping. Analytical Chemistry. 73: 393-404. PMID 11217738 DOI: 10.1021/Ac001130T  0.302
2001 Sakamoto K, Deshaies R, Crews C. Protechials: A novel approach to pharmacological inhibition of protein function Nature Genetics. 27: 83-83. DOI: 10.1038/87274  0.596
2000 Blondel M, Galan JM, Chi Y, Lafourcade C, Longaretti C, Deshaies RJ, Peter M. Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4. The Embo Journal. 19: 6085-97. PMID 11080155 DOI: 10.1093/Emboj/19.22.6085  0.67
2000 Verma R, Chen S, Feldman R, Schieltz D, Yates J, Dohmen J, Deshaies RJ. Proteasomal proteomics: identification of nucleotide-sensitive proteasome-interacting proteins by mass spectrometric analysis of affinity-purified proteasomes. Molecular Biology of the Cell. 11: 3425-39. PMID 11029046 DOI: 10.1091/Mbc.11.10.3425  0.537
2000 Reynard GJ, Reynolds W, Verma R, Deshaies RJ. Cks1 is required for G(1) cyclin-cyclin-dependent kinase activity in budding yeast. Molecular and Cellular Biology. 20: 5858-64. PMID 10913169 DOI: 10.1128/Mcb.20.16.5858-5864.2000  0.498
2000 Deshaies RJ, Meyerowitz E. COP1 patrols the night beat. Nature Cell Biology. 2: E102-4. PMID 10854337 DOI: 10.1038/35014095  0.305
1999 Deshaies RJ, Jacks T. Cell multiplication. Peering in and peering out: regulation of and by the cell cycle. Current Opinion in Cell Biology. 11: 705-7. PMID 10681127 DOI: 10.1016/S0955-0674(99)00040-X  0.337
1999 Deshaies RJ. SCF and Cullin/Ring H2-based ubiquitin ligases. Annual Review of Cell and Developmental Biology. 15: 435-67. PMID 10611969 DOI: 10.1146/Annurev.Cellbio.15.1.435  0.515
1999 Freed E, Lacey KR, Huie P, Lyapina SA, Deshaies RJ, Stearns T, Jackson PK. Components of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycle. Genes & Development. 13: 2242-57. PMID 10485847 DOI: 10.1101/Gad.13.17.2242  0.81
1999 Seol JH, Feldman RM, Zachariae W, Shevchenko A, Correll CC, Lyapina S, Chi Y, Galova M, Claypool J, Sandmeyer S, Nasmyth K, Deshaies RJ, Shevchenko A, Deshaies RJ. Cdc53/cullin and the essential Hrt1 RING-H2 subunit of SCF define a ubiquitin ligase module that activates the E2 enzyme Cdc34. Genes & Development. 13: 1614-26. PMID 10385629 DOI: 10.1101/Gad.13.12.1614  0.828
1999 Straight AF, Shou W, Dowd GJ, Turck CW, Deshaies RJ, Johnson AD, Moazed D. Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity. Cell. 97: 245-56. PMID 10219245 DOI: 10.1016/S0092-8674(00)80734-5  0.643
1999 Shou W, Seol JH, Shevchenko A, Baskerville C, Moazed D, Chen ZW, Jang J, Shevchenko A, Charbonneau H, Deshaies RJ. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell. 97: 233-44. PMID 10219244 DOI: 10.1016/S0092-8674(00)80733-3  0.705
1998 Lyapina SA, Correll CC, Kipreos ET, Deshaies RJ. Human CUL1 forms an evolutionarily conserved ubiquitin ligase complex (SCF) with SKP1 and an F-box protein. Proceedings of the National Academy of Sciences of the United States of America. 95: 7451-6. PMID 9636170 DOI: 10.1073/Pnas.95.13.7451  0.831
1997 Henchoz S, Chi Y, Catarin B, Herskowitz I, Deshaies RJ, Peter M. Phosphorylation- and ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor Far1p in budding yeast. Genes & Development. 11: 3046-60. PMID 9367986 DOI: 10.1101/Gad.11.22.3046  0.646
1997 Feldman RM, Correll CC, Kaplan KB, Deshaies RJ. A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p. Cell. 91: 221-30. PMID 9346239 DOI: 10.1016/S0092-8674(00)80404-3  0.703
1997 Verma R, Annan RS, Huddleston MJ, Carr SA, Reynard G, Deshaies RJ. Phosphorylation of Sic1p by G1 Cdk required for its degradation and entry into S phase. Science (New York, N.Y.). 278: 455-60. PMID 9334303 DOI: 10.1126/Science.278.5337.455  0.391
1997 Verma R, Feldman RM, Deshaies RJ. SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities. Molecular Biology of the Cell. 8: 1427-37. PMID 9285816 DOI: 10.1091/Mbc.8.8.1427  0.712
1997 Verma R, Chi Y, Deshaies RJ. Cell-free ubiquitination of cell cycle regulators in budding yeast extracts. Methods in Enzymology. 283: 366-76. PMID 9251034 DOI: 10.1016/S0076-6879(97)83030-3  0.633
1997 Deshaies RJ. Phosphorylation and proteolysis: partners in the regulation of cell division in budding yeast. Current Opinion in Genetics & Development. 7: 7-16. PMID 9024629 DOI: 10.1016/S0959-437X(97)80103-7  0.49
1996 King RW, Deshaies RJ, Peters JM, Kirschner MW. How proteolysis drives the cell cycle. Science (New York, N.Y.). 274: 1652-9. PMID 8939846 DOI: 10.1126/Science.274.5293.1652  0.735
1995 Deshaies RJ. Make it or break it: the role of ubiquitin-dependent proteolysis in cellular regulation. Trends in Cell Biology. 5: 428-34. PMID 14732048 DOI: 10.1016/S0962-8924(00)89102-3  0.504
1995 Deshaies RJ. The self-destructive personality of a cell cycle in transition. Current Opinion in Cell Biology. 7: 781-9. PMID 8608008 DOI: 10.1016/0955-0674(95)80061-1  0.42
1995 Deshaies RJ, Kirschner M. G1 cyclin-dependent activation of p34CDC28 (Cdc28p) in vitro. Proceedings of the National Academy of Sciences of the United States of America. 92: 1182-6. PMID 7862657 DOI: 10.1073/Pnas.92.4.1182  0.608
1995 Deshaies RJ, Chau V, Kirschner M. Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway. The Embo Journal. 14: 303-12. PMID 7835341 DOI: 10.1002/J.1460-2075.1995.Tb07004.X  0.628
1995 Gerber MR, Farrell A, Deshaies RJ, Herskowitz I, Morgan DO. Cdc37 is required for association of the protein kinase Cdc28 with G1 and mitotic cyclins. Proceedings of the National Academy of Sciences of the United States of America. 92: 4651-5. PMID 7753858 DOI: 10.1073/Pnas.92.10.4651  0.47
1995 Banerjee A, Deshaies RJ, Chau V. Characterization of a dominant negative mutant of the cell cycle ubiquitin-conjugating enzyme Cdc34. The Journal of Biological Chemistry. 270: 26209-15. PMID 7592826 DOI: 10.1074/Jbc.270.44.26209  0.468
1993 Booher RN, Deshaies RJ, Kirschner MW. Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. The Embo Journal. 12: 3417-26. PMID 8253069 DOI: 10.1002/J.1460-2075.1993.Tb06016.X  0.592
1993 Esnault Y, Blondel MO, Deshaies RJ, Scheckman R, Képès F. The yeast SSS1 gene is essential for secretory protein translocation and encodes a conserved protein of the endoplasmic reticulum. The Embo Journal. 12: 4083-93. PMID 8223425 DOI: 10.1002/J.1460-2075.1993.Tb06092.X  0.453
1992 Stirling CJ, Rothblatt J, Hosobuchi M, Deshaies R, Schekman R. Protein translocation mutants defective in the insertion of integral membrane proteins into the endoplasmic reticulum. Molecular Biology of the Cell. 3: 129-42. PMID 1550957 DOI: 10.1091/Mbc.3.2.129  0.595
1991 Deshaies RJ, Sanders SL, Feldheim DA, Schekman R. Assembly of yeast Sec proteins involved in translocation into the endoplasmic reticulum into a membrane-bound multisubunit complex. Nature. 349: 806-8. PMID 2000150 DOI: 10.1038/349806A0  0.763
1990 Deshaies RJ, Schekman R. Structural and functional dissection of Sec62p, a membrane-bound component of the yeast endoplasmic reticulum protein import machinery. Molecular and Cellular Biology. 10: 6024-35. PMID 2233730 DOI: 10.1128/Mcb.10.11.6024  0.583
1989 Deshaies RJ, Schekman R. SEC62 encodes a putative membrane protein required for protein translocation into the yeast endoplasmic reticulum. The Journal of Cell Biology. 109: 2653-64. PMID 2687286 DOI: 10.1083/Jcb.109.6.2653  0.581
1989 Rothblatt JA, Deshaies RJ, Sanders SL, Daum G, Schekman R. Multiple genes are required for proper insertion of secretory proteins into the endoplasmic reticulum in yeast. The Journal of Cell Biology. 109: 2641-52. PMID 2687285 DOI: 10.1083/Jcb.109.6.2641  0.591
1989 Deshaies RJ, Kepes F, Böhni PC. Genetic dissection of the early stages of protein secretion in yeast. Trends in Genetics : Tig. 5: 87-93. PMID 2660366 DOI: 10.1016/0168-9525(89)90032-2  0.408
1988 Böhni PC, Deshaies RJ, Schekman RW. SEC11 is required for signal peptide processing and yeast cell growth. The Journal of Cell Biology. 106: 1035-42. PMID 3283143 DOI: 10.1083/Jcb.106.4.1035  0.58
1988 Deshaies RJ, Koch BD, Werner-Washburne M, Craig EA, Schekman R. A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides. Nature. 332: 800-5. PMID 3282178 DOI: 10.1038/332800A0  0.587
1988 Deshaies RJ, Koch BD, Schekman R. The role of stress proteins in membrane biogenesis. Trends in Biochemical Sciences. 13: 384-8. PMID 3072700 DOI: 10.1016/0968-0004(88)90180-6  0.589
1987 Deshaies RJ, Schekman R. A yeast mutant defective at an early stage in import of secretory protein precursors into the endoplasmic reticulum Journal of Cell Biology. 105: 633-645. PMID 3305520 DOI: 10.1083/Jcb.105.2.633  0.612
1983 Fish LE, Deshaies R, Jagendorf AT. A Mg2+ requirement for rapid ATP-driven protein synthesis by intact pea chloroplasts Plant Science Letters. 31: 139-146. DOI: 10.1016/0304-4211(83)90050-0  0.359
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