Gunnar von Heijne - Publications

Affiliations: 
Stockholm University, Stockholm, Stockholms län, Sweden 
Area:
Membrane insertion of proteins
Website:
http://www.dbb.su.se/en/?p=researchgroup&id=55

202 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Almagro Armenteros JJ, Salvatore M, Emanuelsson O, Winther O, von Heijne G, Elofsson A, Nielsen H. Detecting sequence signals in targeting peptides using deep learning. Life Science Alliance. 2. PMID 31570514 DOI: 10.26508/lsa.201900429  1
2019 Seurig M, Ek M, von Heijne G, Fluman N. Dynamic membrane topology in an unassembled membrane protein. Nature Chemical Biology. PMID 31501590 DOI: 10.1038/s41589-019-0356-9  0.56
2018 Bañó-Polo M, Baeza-Delgado C, Tamborero S, Hazel A, Grau B, Nilsson I, Whitley P, Gumbart JC, von Heijne G, Mingarro I. Transmembrane but not soluble helices fold inside the ribosome tunnel. Nature Communications. 9: 5246. PMID 30531789 DOI: 10.1038/s41467-018-07554-7  0.4
2017 Fluman N, Tobiasson V, von Heijne G. Stable membrane orientations of small dual-topology membrane proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 28698365 DOI: 10.1073/pnas.1706905114  0.56
2016 Söderström B, Mirzadeh K, Toddo S, von Heijne G, Skoglund U, Daley DO. Coordinated disassembly of the divisome complex in Escherichia coli. Molecular Microbiology. PMID 27096604 DOI: 10.1111/mmi.13400  0.72
2016 Baeza-Delgado C, von Heijne G, Marti-Renom MA, Mingarro I. Biological insertion of computationally designed short transmembrane segments. Scientific Reports. 6: 23397. PMID 26987712 DOI: 10.1038/srep23397  0.4
2016 Nilsson OB, Müller-Lucks A, Kramer G, Bukau B, von Heijne G. Trigger factor reduces the force exerted on the nascent chain by a cotranslationally folding protein. Journal of Molecular Biology. PMID 26906929 DOI: 10.1016/j.jmb.2016.02.014  1
2016 Marino J, von Heijne G, Beckmann R. Small protein domains fold inside the ribosome exit tunnel. Febs Letters. PMID 26879042 DOI: 10.1002/1873-3468.12098  1
2015 Nilsson OB, Hedman R, Marino J, Wickles S, Bischoff L, Johansson M, Müller-Lucks A, Trovato F, Puglisi JD, O'Brien EP, Beckmann R, von Heijne G. Cotranslational Protein Folding inside the Ribosome Exit Tunnel. Cell Reports. 12: 1533-40. PMID 26321634 DOI: 10.1016/j.celrep.2015.07.065  1
2015 Goel S, Palmkvist M, Moll K, Joannin N, Lara P, Akhouri RR, Moradi N, Öjemalm K, Westman M, Angeletti D, Kjellin H, Lehtiö J, Blixt O, Ideström L, Gahmberg CG, ... ... von Heijne G, et al. RIFINs are adhesins implicated in severe Plasmodium falciparum malaria. Nature Medicine. 21: 314-7. PMID 25751816 DOI: 10.1038/nm.3812  1
2015 Cymer F, Hedman R, Ismail N, von Heijne G. Exploration of the arrest peptide sequence space reveals arrest-enhanced variants. The Journal of Biological Chemistry. 290: 10208-15. PMID 25713070 DOI: 10.1074/jbc.M115.641555  1
2015 Stone TA, Schiller N, von Heijne G, Deber CM. Hydrophobic blocks facilitate lipid compatibility and translocon recognition of transmembrane protein sequences. Biochemistry. 54: 1465-73. PMID 25635746 DOI: 10.1021/bi5014886  1
2015 Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Ã…, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, ... ... von Heijne G, et al. Proteomics. Tissue-based map of the human proteome. Science (New York, N.Y.). 347: 1260419. PMID 25613900 DOI: 10.1126/science.1260419  1
2015 Ismail N, Hedman R, Lindén M, von Heijne G. Charge-driven dynamics of nascent-chain movement through the SecYEG translocon. Nature Structural & Molecular Biology. 22: 145-9. PMID 25558985 DOI: 10.1038/nsmb.2940  1
2015 Botelho SC, Enquist K, von Heijne G, Draheim RR. Differential repositioning of the second transmembrane helices from E. coli Tar and EnvZ upon moving the flanking aromatic residues. Biochimica Et Biophysica Acta. 1848: 615-21. PMID 25445668 DOI: 10.1016/j.bbamem.2014.11.017  1
2015 Vargas-Uribe M, Rodnin MV, Öjemalm K, Holgado A, Kyrychenko A, Nilsson I, Posokhov YO, Makhatadze G, von Heijne G, Ladokhin AS. Thermodynamics of Membrane Insertion and Refolding of the Diphtheria Toxin T-Domain. The Journal of Membrane Biology. 248: 383-94. PMID 25281329 DOI: 10.1007/s00232-014-9734-0  1
2015 Cymer F, von Heijne G, White SH. Mechanisms of integral membrane protein insertion and folding. Journal of Molecular Biology. 427: 999-1022. PMID 25277655 DOI: 10.1016/j.jmb.2014.09.014  1
2015 Nørholm MH, von Heijne G, Draheim RR. Forcing the issue: aromatic tuning facilitates stimulus-independent modulation of a two-component signaling circuit. Acs Synthetic Biology. 4: 474-81. PMID 25162177 DOI: 10.1021/sb500261t  1
2015 Nilsson I, Lara P, Hessa T, Johnson AE, von Heijne G, Karamyshev AL. The code for directing proteins for translocation across ER membrane: SRP cotranslationally recognizes specific features of a signal sequence. Journal of Molecular Biology. 427: 1191-201. PMID 24979680 DOI: 10.1016/j.jmb.2014.06.014  1
2014 Ulmschneider MB, Ulmschneider JP, Schiller N, Wallace BA, von Heijne G, White SH. Spontaneous transmembrane helix insertion thermodynamically mimics translocon-guided insertion. Nature Communications. 5: 4863. PMID 25204588 DOI: 10.1038/ncomms5863  1
2014 Björkholm P, Ernst AM, Hacke M, Wieland F, Brügger B, von Heijne G. Identification of novel sphingolipid-binding motifs in mammalian membrane proteins. Biochimica Et Biophysica Acta. 1838: 2066-70. PMID 24796501 DOI: 10.1016/j.bbamem.2014.04.026  1
2014 Virkki M, Boekel C, Illergård K, Peters C, Shu N, Tsirigos KD, Elofsson A, von Heijne G, Nilsson I. Large tilts in transmembrane helices can be induced during tertiary structure formation. Journal of Molecular Biology. 426: 2529-38. PMID 24793448 DOI: 10.1016/j.jmb.2014.04.020  1
2014 Cymer F, Ismail N, von Heijne G. Weak pulling forces exerted on Nin-orientated transmembrane segments during co-translational insertion into the inner membrane of Escherichia coli. Febs Letters. 588: 1930-4. PMID 24726730 DOI: 10.1016/j.febslet.2014.03.050  1
2014 Lloris-Garcerá P, Seppälä S, Slusky JS, Rapp M, von Heijne G. Why have small multidrug resistance proteins not evolved into fused, internally duplicated structures? Journal of Molecular Biology. 426: 2246-54. PMID 24690367 DOI: 10.1016/j.jmb.2014.03.012  1
2014 Söderström B, Skoog K, Blom H, Weiss DS, von Heijne G, Daley DO. Disassembly of the divisome in Escherichia coli: evidence that FtsZ dissociates before compartmentalization. Molecular Microbiology. 92: 1-9. PMID 24506818 DOI: 10.1111/mmi.12534  1
2014 Karamyshev AL, Patrick AE, Karamysheva ZN, Griesemer DS, Hudson H, Tjon-Kon-Sang S, Nilsson I, Otto H, Liu Q, Rospert S, von Heijne G, Johnson AE, Thomas PJ. Inefficient SRP interaction with a nascent chain triggers a mRNA quality control pathway. Cell. 156: 146-57. PMID 24439374 DOI: 10.1016/j.cell.2013.12.017  1
2014 Ismail N, Hedman R, Schiller N, Cymer F, Nilsson O, Von Heijne G. Arrest peptides as force sensors to study co-translational membrane protein biogenesis Regulatory Nascent Polypeptides. 279-290. DOI: 10.1007/978-4-431-55052-5_16  1
2013 Reithinger JH, Yim C, Park K, Björkholm P, von Heijne G, Kim H. A short C-terminal tail prevents mis-targeting of hydrophobic mitochondrial membrane proteins to the ER. Febs Letters. 587: 3480-6. PMID 24055247 DOI: 10.1016/j.febslet.2013.08.041  1
2013 Cymer F, von Heijne G. Cotranslational folding of membrane proteins probed by arrest-peptide-mediated force measurements. Proceedings of the National Academy of Sciences of the United States of America. 110: 14640-5. PMID 23959879 DOI: 10.1073/pnas.1306787110  1
2013 Lloris-Garcerá P, Slusky JS, Seppälä S, Prieß M, Schäfer LV, von Heijne G. In vivo trp scanning of the small multidrug resistance protein EmrE confirms 3D structure models'. Journal of Molecular Biology. 425: 4642-51. PMID 23920359 DOI: 10.1016/j.jmb.2013.07.039  1
2013 Nørholm MH, Toddo S, Virkki MT, Light S, von Heijne G, Daley DO. Improved production of membrane proteins in Escherichia coli by selective codon substitutions. Febs Letters. 587: 2352-8. PMID 23769986 DOI: 10.1016/j.febslet.2013.05.063  1
2013 Ojemalm K, Botelho SC, Stüdle C, von Heijne G. Quantitative analysis of SecYEG-mediated insertion of transmembrane α-helices into the bacterial inner membrane. Journal of Molecular Biology. 425: 2813-22. PMID 23659793 DOI: 10.1016/j.jmb.2013.04.025  1
2013 Botelho SC, Tatsuta T, von Heijne G, Kim H. Dislocation by the m-AAA protease increases the threshold hydrophobicity for retention of transmembrane helices in the inner membrane of yeast mitochondria. The Journal of Biological Chemistry. 288: 4792-8. PMID 23283966 DOI: 10.1074/jbc.M112.430892  1
2013 Öjemalm K, Watson HR, Roboti P, Cross BC, Warwicker J, von Heijne G, High S. Positional editing of transmembrane domains during ion channel assembly. Journal of Cell Science. 126: 464-72. PMID 23230148 DOI: 10.1242/jcs.111773  1
2012 Lee H, Min J, von Heijne G, Kim H. Glycosylatable GFP as a compartment-specific membrane topology reporter. Biochemical and Biophysical Research Communications. 427: 780-4. PMID 23047006 DOI: 10.1016/j.bbrc.2012.09.138  1
2012 Ismail N, Hedman R, Schiller N, von Heijne G. A biphasic pulling force acts on transmembrane helices during translocon-mediated membrane integration. Nature Structural & Molecular Biology. 19: 1018-22. PMID 23001004 DOI: 10.1038/nsmb.2376  1
2012 Toddo S, Söderström B, Palombo I, von Heijne G, Nørholm MH, Daley DO. Application of split-green fluorescent protein for topology mapping membrane proteins in Escherichia coli. Protein Science : a Publication of the Protein Society. 21: 1571-6. PMID 22825803 DOI: 10.1002/pro.2131  1
2012 Lloris-Garcerá P, Bianchi F, Slusky JS, Seppälä S, Daley DO, von Heijne G. Antiparallel dimers of the small multidrug resistance protein EmrE are more stable than parallel dimers. The Journal of Biological Chemistry. 287: 26052-9. PMID 22700980 DOI: 10.1074/jbc.M112.357590  1
2012 Galian C, Björkholm P, Bulleid N, von Heijne G. Efficient glycosylphosphatidylinositol (GPI) modification of membrane proteins requires a C-terminal anchoring signal of marginal hydrophobicity. The Journal of Biological Chemistry. 287: 16399-409. PMID 22431723 DOI: 10.1074/jbc.M112.350009  1
2012 Ojemalm K, Halling KK, Nilsson I, von Heijne G. Orientational preferences of neighboring helices can drive ER insertion of a marginally hydrophobic transmembrane helix. Molecular Cell. 45: 529-40. PMID 22281052 DOI: 10.1016/j.molcel.2011.12.024  1
2012 Contreras FX, Ernst AM, Haberkant P, Björkholm P, Lindahl E, Gönen B, Tischer C, Elofsson A, von Heijne G, Thiele C, Pepperkok R, Wieland F, Brügger B. Molecular recognition of a single sphingolipid species by a protein's transmembrane domain. Nature. 481: 525-9. PMID 22230960 DOI: 10.1038/nature10742  1
2012 Skoog K, Söderström B, Widengren J, von Heijne G, Daley DO. Sequential closure of the cytoplasm and then the periplasm during cell division in Escherichia coli. Journal of Bacteriology. 194: 584-6. PMID 22101847 DOI: 10.1128/JB.06091-11  1
2012 Nørholm MH, Light S, Virkki MT, Elofsson A, von Heijne G, Daley DO. Manipulating the genetic code for membrane protein production: what have we learnt so far? Biochimica Et Biophysica Acta. 1818: 1091-6. PMID 21884679 DOI: 10.1016/j.bbamem.2011.08.018  1
2012 Von Heijne G. The right approach Ebr - European Biopharmaceutical Review. 80-81.  1
2011 Petersen TN, Brunak S, von Heijne G, Nielsen H. SignalP 4.0: discriminating signal peptides from transmembrane regions. Nature Methods. 8: 785-6. PMID 21959131 DOI: 10.1038/nmeth.1701  1
2011 von Heijne G. Introduction to theme "membrane protein folding and insertion". Annual Review of Biochemistry. 80: 157-60. PMID 21675916 DOI: 10.1146/annurev-biochem-111910-091345  1
2011 Nørholm MH, Shulga YV, Aoki S, Epand RM, von Heijne G. Flanking residues help determine whether a hydrophobic segment adopts a monotopic or bitopic topology in the endoplasmic reticulum membrane. The Journal of Biological Chemistry. 286: 25284-90. PMID 21606504 DOI: 10.1074/jbc.M111.244616  1
2011 Öjemalm K, Higuchi T, Jiang Y, Langel Ü, Nilsson I, White SH, Suga H, von Heijne G. Apolar surface area determines the efficiency of translocon-mediated membrane-protein integration into the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America. 108: E359-64. PMID 21606334 DOI: 10.1073/pnas.1100120108  1
2011 von Heijne G. Membrane proteins: from bench to bits. Biochemical Society Transactions. 39: 747-50. PMID 21599644 DOI: 10.1042/BST0390747  1
2011 Osterberg M, Calado Botelho S, von Heijne G, Kim H. Charged flanking residues control the efficiency of membrane insertion of the first transmembrane segment in yeast mitochondrial Mgm1p. Febs Letters. 585: 1238-42. PMID 21457713 DOI: 10.1016/j.febslet.2011.03.056  1
2011 Botelho SC, Osterberg M, Reichert AS, Yamano K, Björkholm P, Endo T, von Heijne G, Kim H. TIM23-mediated insertion of transmembrane α-helices into the mitochondrial inner membrane. The Embo Journal. 30: 1003-11. PMID 21326212 DOI: 10.1038/emboj.2011.29  1
2011 Nørholm MH, Cunningham F, Deber CM, von Heijne G. Converting a marginally hydrophobic soluble protein into a membrane protein. Journal of Molecular Biology. 407: 171-9. PMID 21262233 DOI: 10.1016/j.jmb.2011.01.035  1
2011 Schow EV, Freites JA, Cheng P, Bernsel A, von Heijne G, White SH, Tobias DJ. Arginine in membranes: the connection between molecular dynamics simulations and translocon-mediated insertion experiments. The Journal of Membrane Biology. 239: 35-48. PMID 21127848 DOI: 10.1007/s00232-010-9330-x  1
2010 Seppälä S, Slusky JS, Lloris-Garcerá P, Rapp M, von Heijne G. Control of membrane protein topology by a single C-terminal residue. Science (New York, N.Y.). 328: 1698-700. PMID 20508091 DOI: 10.1126/science.1188950  1
2010 Fagerberg L, Jonasson K, von Heijne G, Uhlén M, Berglund L. Prediction of the human membrane proteome. Proteomics. 10: 1141-9. PMID 20175080 DOI: 10.1002/pmic.200900258  1
2010 Strömqvist J, Skoog K, Daley DO, Widengren J, von Heijne G. Estimating Z-ring radius and contraction in dividing Escherichia coli. Molecular Microbiology. 76: 151-8. PMID 20149104 DOI: 10.1111/j.1365-2958.2010.07087.x  1
2010 Kauko A, Hedin LE, Thebaud E, Cristobal S, Elofsson A, von Heijne G. Repositioning of transmembrane alpha-helices during membrane protein folding. Journal of Molecular Biology. 397: 190-201. PMID 20109468 DOI: 10.1016/j.jmb.2010.01.042  1
2010 Sakata S, Kurokawa T, Nørholm MH, Takagi M, Okochi Y, von Heijne G, Okamura Y. Functionality of the voltage-gated proton channel truncated in S4. Proceedings of the National Academy of Sciences of the United States of America. 107: 2313-8. PMID 20018719 DOI: 10.1073/pnas.0911868107  1
2010 Daniels R, Mellroth P, Bernsel A, Neiers F, Normark S, von Heijne G, Henriques-Normark B. Disulfide bond formation and cysteine exclusion in gram-positive bacteria. The Journal of Biological Chemistry. 285: 3300-9. PMID 19940132 DOI: 10.1074/jbc.M109.081398  1
2010 Hedin LE, Ojemalm K, Bernsel A, Hennerdal A, Illergård K, Enquist K, Kauko A, Cristobal S, von Heijne G, Lerch-Bader M, Nilsson I, Elofsson A. Membrane insertion of marginally hydrophobic transmembrane helices depends on sequence context. Journal of Molecular Biology. 396: 221-9. PMID 19931281 DOI: 10.1016/j.jmb.2009.11.036  1
2009 Jaud S, Fernández-Vidal M, Nilsson I, Meindl-Beinker NM, Hübner NC, Tobias DJ, von Heijne G, White SH. Insertion of short transmembrane helices by the Sec61 translocon. Proceedings of the National Academy of Sciences of the United States of America. 106: 11588-93. PMID 19581593 DOI: 10.1073/pnas.0900638106  1
2009 Hessa T, Reithinger JH, von Heijne G, Kim H. Analysis of transmembrane helix integration in the endoplasmic reticulum in S. cerevisiae. Journal of Molecular Biology. 386: 1222-8. PMID 19452628 DOI: 10.1016/j.jmb.2009.01.027  1
2009 Enquist K, Fransson M, Boekel C, Bengtsson I, Geiger K, Lang L, Pettersson A, Johansson S, von Heijne G, Nilsson I. Membrane-integration characteristics of two ABC transporters, CFTR and P-glycoprotein. Journal of Molecular Biology. 387: 1153-64. PMID 19236881 DOI: 10.1016/j.jmb.2009.02.035  1
2009 Juncker AS, Jensen LJ, Pierleoni A, Bernsel A, Tress ML, Bork P, von Heijne G, Valencia A, Ouzounis CA, Casadio R, Brunak S. Sequence-based feature prediction and annotation of proteins. Genome Biology. 10: 206. PMID 19226438 DOI: 10.1186/gb-2009-10-2-206  1
2008 Lundin C, Kim H, Nilsson I, White SH, von Heijne G. Molecular code for protein insertion in the endoplasmic reticulum membrane is similar for N(in)-C(out) and N(out)-C(in) transmembrane helices. Proceedings of the National Academy of Sciences of the United States of America. 105: 15702-7. PMID 18840693 DOI: 10.1073/pnas.0804842105  1
2008 von Heijne G, Rees D. Membranes: reading between the lines. Current Opinion in Structural Biology. 18: 403-5. PMID 18634876 DOI: 10.1016/j.sbi.2008.06.003  1
2008 Cassel M, Seppälä S, von Heijne G. Confronting fusion protein-based membrane protein topology mapping with reality: the Escherichia coli ClcA H+/Cl- exchange transporter. Journal of Molecular Biology. 381: 860-6. PMID 18590742 DOI: 10.1016/j.jmb.2008.06.039  1
2008 White SH, von Heijne G. How translocons select transmembrane helices. Annual Review of Biophysics. 37: 23-42. PMID 18573071 DOI: 10.1146/annurev.biophys.37.032807.125904  1
2008 Bernsel A, Viklund H, Falk J, Lindahl E, von Heijne G, Elofsson A. Prediction of membrane-protein topology from first principles. Proceedings of the National Academy of Sciences of the United States of America. 105: 7177-81. PMID 18477697 DOI: 10.1073/pnas.0711151105  1
2008 Drew D, Newstead S, Sonoda Y, Kim H, von Heijne G, Iwata S. GFP-based optimization scheme for the overexpression and purification of eukaryotic membrane proteins in Saccharomyces cerevisiae. Nature Protocols. 3: 784-98. PMID 18451787 DOI: 10.1038/nprot.2008.44  1
2008 Lerch-Bader M, Lundin C, Kim H, Nilsson I, von Heijne G. Contribution of positively charged flanking residues to the insertion of transmembrane helices into the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America. 105: 4127-32. PMID 18326626 DOI: 10.1073/pnas.0711580105  1
2008 Casadio R, Fariselli P, Martelli PL, Pierleoni A, Rossi I, Von Heijne G. The state of the art of membrane protein structure prediction: From sequence to 3D structure Modern Genome Annotation: the Biosapiens Network. 309-326. DOI: 10.1007/978-3-211-75123-7_15  1
2007 Hessa T, Meindl-Beinker NM, Bernsel A, Kim H, Sato Y, Lerch-Bader M, Nilsson I, White SH, von Heijne G. Molecular code for transmembrane-helix recognition by the Sec61 translocon. Nature. 450: 1026-30. PMID 18075582 DOI: 10.1038/nature06387  1
2007 Xie K, Hessa T, Seppälä S, Rapp M, von Heijne G, Dalbey RE. Features of transmembrane segments that promote the lateral release from the translocase into the lipid phase. Biochemistry. 46: 15153-61. PMID 18052199 DOI: 10.1021/bi701398y  1
2007 Lundin C, Käll L, Kreher SA, Kapp K, Sonnhammer EL, Carlson JR, Heijne Gv, Nilsson I. Membrane topology of the Drosophila OR83b odorant receptor. Febs Letters. 581: 5601-4. PMID 18005664 DOI: 10.1016/j.febslet.2007.11.007  0.44
2007 Granseth E, Seppälä S, Rapp M, Daley DO, Von Heijne G. Membrane protein structural biology--how far can the bugs take us? Molecular Membrane Biology. 24: 329-32. PMID 17710636 DOI: 10.1080/09687680701413882  1
2007 Newstead S, Kim H, von Heijne G, Iwata S, Drew D. High-throughput fluorescent-based optimization of eukaryotic membrane protein overexpression and purification in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 104: 13936-41. PMID 17709746 DOI: 10.1073/pnas.0704546104  1
2007 Lundin C, Johansson S, Johnson AE, Näslund J, von Heijne G, Nilsson I. Stable insertion of Alzheimer Abeta peptide into the ER membrane strongly correlates with its length. Febs Letters. 581: 3809-13. PMID 17659280 DOI: 10.1016/j.febslet.2007.07.003  1
2007 Stenberg F, von Heijne G, Daley DO. Assembly of the cytochrome bo3 complex. Journal of Molecular Biology. 371: 765-73. PMID 17583738 DOI: 10.1016/j.jmb.2007.05.045  1
2007 Elofsson A, von Heijne G. Membrane protein structure: prediction versus reality. Annual Review of Biochemistry. 76: 125-40. PMID 17579561 DOI: 10.1146/annurev.biochem.76.052705.163539  1
2007 von Heijne G. Membrane proteins up for grabs. Nature Biotechnology. 25: 646-7. PMID 17557100 DOI: 10.1038/nbt0607-646  1
2007 von Heijne G. The membrane protein universe: what's out there and why bother? Journal of Internal Medicine. 261: 543-57. PMID 17547710 DOI: 10.1111/j.1365-2796.2007.01792.x  1
2007 Zhang L, Sato Y, Hessa T, von Heijne G, Lee JK, Kodama I, Sakaguchi M, Uozumi N. Contribution of hydrophobic and electrostatic interactions to the membrane integration of the Shaker K+ channel voltage sensor domain. Proceedings of the National Academy of Sciences of the United States of America. 104: 8263-8. PMID 17488813 DOI: 10.1073/pnas.0611007104  1
2007 Emanuelsson O, Brunak S, von Heijne G, Nielsen H. Locating proteins in the cell using TargetP, SignalP and related tools. Nature Protocols. 2: 953-71. PMID 17446895 DOI: 10.1038/nprot.2007.131  1
2007 von Heijne G. Formation of transmembrane helices in vivo--is hydrophobicity all that matters? The Journal of General Physiology. 129: 353-6. PMID 17438115 DOI: 10.1085/jgp.200709740  1
2007 Rapp M, Seppälä S, Granseth E, von Heijne G. Emulating membrane protein evolution by rational design. Science (New York, N.Y.). 315: 1282-4. PMID 17255477 DOI: 10.1126/science.1135406  1
2007 Rapp M, Seppälä S, Granseth E, Von Heijne G. Response [4] Science. 317: 749-750.  1
2006 von Heijne G. Membrane-protein topology. Nature Reviews. Molecular Cell Biology. 7: 909-18. PMID 17139331 DOI: 10.1038/nrm2063  1
2006 Meindl-Beinker NM, Lundin C, Nilsson I, White SH, von Heijne G. Asn- and Asp-mediated interactions between transmembrane helices during translocon-mediated membrane protein assembly. Embo Reports. 7: 1111-6. PMID 17008929 DOI: 10.1038/sj.embor.7400818  1
2006 Kim H, Melén K, Osterberg M, von Heijne G. A global topology map of the Saccharomyces cerevisiae membrane proteome. Proceedings of the National Academy of Sciences of the United States of America. 103: 11142-7. PMID 16847258 DOI: 10.1073/pnas.0604075103  1
2006 Osterberg M, Kim H, Warringer J, Melén K, Blomberg A, von Heijne G. Phenotypic effects of membrane protein overexpression in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 103: 11148-53. PMID 16847257 DOI: 10.1073/pnas.0604078103  1
2006 Amico M, Finelli M, Rossi I, Zauli A, Elofsson A, Viklund H, von Heijne G, Jones D, Krogh A, Fariselli P, Luigi Martelli P, Casadio R. PONGO: a web server for multiple predictions of all-alpha transmembrane proteins. Nucleic Acids Research. 34: W169-72. PMID 16844984 DOI: 10.1093/nar/gkl208  1
2006 Lundin C, Nordström R, Wagner K, Windpassinger C, Andersson H, von Heijne G, Nilsson I. Membrane topology of the human seipin protein. Febs Letters. 580: 2281-4. PMID 16574104 DOI: 10.1016/j.febslet.2006.03.040  1
2006 Marani P, Wagner S, Baars L, Genevaux P, de Gier JW, Nilsson I, Casadio R, von Heijne G. New Escherichia coli outer membrane proteins identified through prediction and experimental verification. Protein Science : a Publication of the Protein Society. 15: 884-9. PMID 16522795 DOI: 10.1110/ps.051889506  1
2006 Rapp M, Granseth E, Seppälä S, von Heijne G. Identification and evolution of dual-topology membrane proteins. Nature Structural & Molecular Biology. 13: 112-6. PMID 16429150 DOI: 10.1038/nsmb1057  1
2006 Björklund A, Thorén A, von Heijne G, Elofsson A. The use of phylogenetic profiles for gene predictions revisited Current Genomics. 7: 79-86. DOI: 10.2174/138920206777304650  1
2006 White SH, Hessa T, von Heijne G. Lipid Bilayers, Translocons and the Shaping of Polypeptide Structure Protein-Lipid Interactions: From Membrane Domains to Cellular Networks. 1-25. DOI: 10.1002/3527606769.ch1  1
2005 Villarejo A, Burén S, Larsson S, Déjardin A, Monné M, Rudhe C, Karlsson J, Jansson S, Lerouge P, Rolland N, von Heijne G, Grebe M, Bako L, Samuelsson G. Evidence for a protein transported through the secretory pathway en route to the higher plant chloroplast. Nature Cell Biology. 7: 1224-31. PMID 16284624 DOI: 10.1038/ncb1330  1
2005 White SH, von Heijne G. Do protein-lipid interactions determine the recognition of transmembrane helices at the ER translocon? Biochemical Society Transactions. 33: 1012-5. PMID 16246034 DOI: 10.1042/BST20051012  1
2005 Freites JA, Tobias DJ, von Heijne G, White SH. Interface connections of a transmembrane voltage sensor. Proceedings of the National Academy of Sciences of the United States of America. 102: 15059-64. PMID 16217012 DOI: 10.1073/pnas.0507618102  1
2005 Karamyshev AL, Kelleher DJ, Gilmore R, Johnson AE, von Heijne G, Nilsson I. Mapping the interaction of the STT3 subunit of the oligosaccharyl transferase complex with nascent polypeptide chains. The Journal of Biological Chemistry. 280: 40489-93. PMID 16216884 DOI: 10.1074/jbc.M509168200  1
2005 von Heijne G. Helices on the move. Nature Structural & Molecular Biology. 12: 834-5. PMID 16205705 DOI: 10.1038/nsmb1005-834  1
2005 Pasche B, Knobloch TJ, Bian Y, Liu J, Phukan S, Rosman D, Kaklamani V, Baddi L, Siddiqui FS, Frankel W, Prior TW, Schuller DE, Agrawal A, Lang J, Dolan ME, ... ... von Heijne G, et al. Somatic acquisition and signaling of TGFBR1*6A in cancer. Jama. 294: 1634-46. PMID 16204663 DOI: 10.1001/jama.294.13.1634  1
2005 Médigue C, Krin E, Pascal G, Barbe V, Bernsel A, Bertin PN, Cheung F, Cruveiller S, D'Amico S, Duilio A, Fang G, Feller G, Ho C, Mangenot S, Marino G, ... ... von Heijne G, et al. Coping with cold: the genome of the versatile marine Antarctica bacterium Pseudoalteromonas haloplanktis TAC125. Genome Research. 15: 1325-35. PMID 16169927 DOI: 10.1101/gr.4126905  1
2005 Luirink J, von Heijne G, Houben E, de Gier JW. Biogenesis of inner membrane proteins in Escherichia coli. Annual Review of Microbiology. 59: 329-55. PMID 16153172 DOI: 10.1146/annurev.micro.59.030804.121246  1
2005 Granseth E, Daley DO, Rapp M, Melén K, von Heijne G. Experimentally constrained topology models for 51,208 bacterial inner membrane proteins. Journal of Molecular Biology. 352: 489-94. PMID 16120447 DOI: 10.1016/j.jmb.2005.07.053  1
2005 Stenberg F, Chovanec P, Maslen SL, Robinson CV, Ilag LL, von Heijne G, Daley DO. Protein complexes of the Escherichia coli cell envelope. The Journal of Biological Chemistry. 280: 34409-19. PMID 16079137 DOI: 10.1074/jbc.M506479200  1
2005 von Heijne G. Microbiology. Translocation of anthrax toxin: lord of the rings. Science (New York, N.Y.). 309: 709-10. PMID 16051774 DOI: 10.1126/science.1116630  1
2005 Laudon H, Hansson EM, Melén K, Bergman A, Farmery MR, Winblad B, Lendahl U, von Heijne G, Näslund J. A nine-transmembrane domain topology for presenilin 1. The Journal of Biological Chemistry. 280: 35352-60. PMID 16046406 DOI: 10.1074/jbc.M507217200  1
2005 White SH, von Heijne G. Transmembrane helices before, during, and after insertion. Current Opinion in Structural Biology. 15: 378-86. PMID 16043344 DOI: 10.1016/j.sbi.2005.07.004  1
2005 Nilsson J, Persson B, von Heijne G. Comparative analysis of amino acid distributions in integral membrane proteins from 107 genomes. Proteins. 60: 606-16. PMID 16028222 DOI: 10.1002/prot.20583  1
2005 Bernsel A, Von Heijne G. Improved membrane protein topology prediction by domain assignments. Protein Science : a Publication of the Protein Society. 14: 1723-8. PMID 15987901 DOI: 10.1110/ps.051395305  1
2005 Daley DO, Rapp M, Granseth E, Melén K, Drew D, von Heijne G. Global topology analysis of the Escherichia coli inner membrane proteome. Science (New York, N.Y.). 308: 1321-3. PMID 15919996 DOI: 10.1126/science.1109730  1
2005 Kim H, von Heijne G, Nilsson I. Membrane topology of the STT3 subunit of the oligosaccharyl transferase complex. The Journal of Biological Chemistry. 280: 20261-7. PMID 15781470 DOI: 10.1074/jbc.M412213200  1
2005 Tie JK, Nicchitta C, von Heijne G, Stafford DW. Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. The Journal of Biological Chemistry. 280: 16410-6. PMID 15716279 DOI: 10.1074/jbc.M500765200  1
2005 Hessa T, White SH, von Heijne G. Membrane insertion of a potassium-channel voltage sensor. Science (New York, N.Y.). 307: 1427. PMID 15681341 DOI: 10.1126/science.1109176  1
2005 Ding B, Kull B, Liu Z, Mottagui-Tabar S, Thonberg H, Gu HF, Brookes AJ, Grundemar L, Karlsson C, Hamsten A, Arner P, Ostenson CG, Efendic S, Monné M, von Heijne G, et al. Human neuropeptide Y signal peptide gain-of-function polymorphism is associated with increased body mass index: possible mode of function. Regulatory Peptides. 127: 45-53. PMID 15680469 DOI: 10.1016/j.regpep.2004.10.011  1
2005 Hessa T, Kim H, Bihlmaier K, Lundin C, Boekel J, Andersson H, Nilsson I, White SH, von Heijne G. Recognition of transmembrane helices by the endoplasmic reticulum translocon. Nature. 433: 377-81. PMID 15674282 DOI: 10.1038/nature03216  1
2005 Granseth E, von Heijne G, Elofsson A. A study of the membrane-water interface region of membrane proteins. Journal of Molecular Biology. 346: 377-85. PMID 15663952 DOI: 10.1016/j.jmb.2004.11.036  1
2005 Monné M, Hessa T, Thissen L, von Heijne G. Competition between neighboring topogenic signals during membrane protein insertion into the ER. The Febs Journal. 272: 28-36. PMID 15634329 DOI: 10.1111/j.1742-4658.2004.04394.x  1
2004 Kerje S, Sharma P, Gunnarsson U, Kim H, Bagchi S, Fredriksson R, Schütz K, Jensen P, von Heijne G, Okimoto R, Andersson L. The Dominant white, Dun and Smoky color variants in chicken are associated with insertion/deletion polymorphisms in the PMEL17 gene. Genetics. 168: 1507-18. PMID 15579702 DOI: 10.1534/genetics.104.027995  1
2004 Bendtsen JD, Nielsen H, von Heijne G, Brunak S. Improved prediction of signal peptides: SignalP 3.0. Journal of Molecular Biology. 340: 783-95. PMID 15223320 DOI: 10.1016/j.jmb.2004.05.028  1
2004 Bendtsen JD, Jensen LJ, Blom N, Von Heijne G, Brunak S. Feature-based prediction of non-classical and leaderless protein secretion. Protein Engineering, Design & Selection : Peds. 17: 349-56. PMID 15115854 DOI: 10.1093/protein/gzh037  1
2004 Rapp M, Drew D, Daley DO, Nilsson J, Carvalho T, Melén K, De Gier JW, Von Heijne G. Experimentally based topology models for E. coli inner membrane proteins. Protein Science : a Publication of the Protein Society. 13: 937-45. PMID 15044727 DOI: 10.1110/ps.03553804  1
2004 Stefansson A, Armulik A, Nilsson I, Von Heijne G, Johansson S. Determination of N- and C-terminal borders of the transmembrane domain of integrin subunits Journal of Biological Chemistry. 279: 21200-21205. PMID 15016834 DOI: 10.1074/jbc.M400771200  1
2003 Hermansson M, von Heijne G. Inter-helical hydrogen bond formation during membrane protein integration into the ER membrane. Journal of Molecular Biology. 334: 803-9. PMID 14636604 DOI: 10.1016/j.jmb.2003.10.019  1
2003 Westerlund I, Von Heijne G, Emanuelsson O. LumenP - A neural network predictor for protein localization in the thylakoid lumen Protein Science. 12: 2360-2366. PMID 14500894 DOI: 10.1110/ps.0306003  1
2003 Andersson H, D'Antona AM, Kendall DA, Von Heijne G, Chin CN. Membrane assembly of the cannabinoid receptor 1: impact of a long N-terminal tail. Molecular Pharmacology. 64: 570-7. PMID 12920192 DOI: 10.1124/mol.64.3.570  1
2003 Juncker AS, Willenbrock H, Von Heijne G, Brunak S, Nielsen H, Krogh A. Prediction of lipoprotein signal peptides in Gram-negative bacteria. Protein Science : a Publication of the Protein Society. 12: 1652-62. PMID 12876315 DOI: 10.1110/ps.0303703  1
2003 Emanuelsson O, Elofsson A, von Heijne G, Cristóbal S. In silico prediction of the peroxisomal proteome in fungi, plants and animals. Journal of Molecular Biology. 330: 443-56. PMID 12823981 DOI: 10.1016/S0022-2836(03)00553-9  1
2003 Kim H, Yan Q, Von Heijne G, Caputo GA, Lennarz WJ. Determination of the membrane topology of Ost4p and its subunit interactions in the oligosaccharyltransferase complex in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 100: 7460-4. PMID 12810948 DOI: 10.1073/pnas.1332735100  1
2003 Nilsson I, Johnson AE, Von Heijne G. How hydrophobic is alanine? Journal of Biological Chemistry. 278: 29389-29393. PMID 12761228 DOI: 10.1074/jbc.M212310200  1
2003 Nilsson I, Kelleher DJ, Miao Y, Shao Y, Kreibich G, Gilmore R, von Heijne G, Johnson AE. Photocross-linking of nascent chains to the STT3 subunit of the oligosaccharyltransferase complex. The Journal of Cell Biology. 161: 715-25. PMID 12756234 DOI: 10.1083/jcb.200301043  1
2003 Lundin M, Monné M, Widell A, Von Heijne G, Persson MAA. Topology of the membrane-associated hepatitis C virus protein NS4B Journal of Virology. 77: 5428-5438. PMID 12692244 DOI: 10.1128/JVI.77.9.5428-5438.2003  1
2003 Melén K, Krogh A, von Heijne G. Reliability measures for membrane protein topology prediction algorithms. Journal of Molecular Biology. 327: 735-44. PMID 12634065 DOI: 10.1016/S0022-2836(03)00182-7  1
2003 Von Heijne G. Membrane protein assembly in vivo Advances in Protein Chemistry. 63: 1-18. PMID 12629964 DOI: 10.1016/S0065-3233(03)63001-9  1
2003 Hessa T, Monné M, von Heijne G. Stop-transfer efficiency of marginally hydrophobic segments depends on the length of the carboxy-terminal tail Embo Reports. 4: 178-183. PMID 12612608 DOI: 10.1038/sj.embor.embor728  1
2003 Hucke O, Schiltz E, Drews G, Labahn A, Von Heijne G. Sequence analysis reveals new membrane anchor of reaction centre-bound cytochromes possibly related to PufX Febs Letters. 535: 166-170. PMID 12560097 DOI: 10.1016/S0014-5793(02)03899-1  1
2003 Kim H, Melén K, Von Heijne G. Topology models for 37 Saccharomyces cerevisiae membrane proteins based on C-terminal reporter fusions and predictions Journal of Biological Chemistry. 278: 10208-10213. PMID 12524434 DOI: 10.1074/jbc.M300163200  1
2003 Brzezinski P, Von Heijne G, Rydström J. Membrane proteins: Structure, function and assembly Febs Letters. 555: 1. DOI: 10.1016/S0014-5793(03)01147-5  1
2002 Nilsson J, Persson B, Von Heijne G. Prediction of partial membrane protein topologies using a consensus approach Protein Science. 11: 2974-2980. PMID 12441395 DOI: 10.1110/ps.0226702  1
2002 Chin CN, von Heijne G, de Gier JW. Membrane proteins: shaping up. Trends in Biochemical Sciences. 27: 231-4. PMID 12076534 DOI: 10.1016/S0968-0004(02)02082-0  1
2002 von Heijne G. Bioinformatics of membrane proteins Ernst Schering Research Foundation Workshop. 17-27. PMID 12061002  1
2002 Vilar M, Saurí A, Monné M, Marcos JF, Von Heijne G, Pérez-Payá E, Mingarro I. Insertion and topology of a plant viral movement protein in the endoplasmic reticulum membrane Journal of Biological Chemistry. 277: 23447-23452. PMID 11976343 DOI: 10.1074/jbc.M202935200  1
2002 Nilsson I, Johnson AE, Von Heijne G. Cleavage of a tail-anchored protein by signal peptidase Febs Letters. 516: 106-108. PMID 11959113 DOI: 10.1016/S0014-5793(02)02511-5  1
2002 Drew D, Sjöstrand D, Nilsson J, Urbig T, Chin CN, de Gier JW, von Heijne G. Rapid topology mapping of Escherichia coli inner-membrane proteins by prediction and PhoA/GFP fusion analysis. Proceedings of the National Academy of Sciences of the United States of America. 99: 2690-5. PMID 11867724 DOI: 10.1073/pnas.052018199  1
2002 Hedman M, Deloof H, Von Heijne G, Elofsson A. Improved detection of homologous membrane proteins by inclusion of information from topology predictions. Protein Science : a Publication of the Protein Society. 11: 652-8. PMID 11847287 DOI: 10.1110/ps.39402  1
2002 Peltier JB, Emanuelsson O, Kalume DE, Ytterberg J, Friso G, Rudella A, Liberles DA, Söderberg L, Roepstorff P, von Heijne G, van Wijk KJ. Central functions of the lumenal and peripheral thylakoid proteome of Arabidopsis determined by experimentation and genome-wide prediction. The Plant Cell. 14: 211-36. PMID 11826309 DOI: 10.1105/tpc.010304  1
2002 Liberles DA, Thorén A, von Heijne G, Elofsson A. The use of phylogenetic profiles for gene predictions Current Genomics. 3: 131-137. DOI: 10.2174/1389202023350499  1
2001 Emanuelsson O, Von Heijne G. Prediction of organellar targeting signals Biochimica Et Biophysica Acta - Molecular Cell Research. 1541: 114-119. PMID 11750667 DOI: 10.1016/S0167-4889(01)00145-8  1
2001 Hermansson M, Monné M, von Heijne G. Formation of helical hairpins during membrane protein integration into the endoplasmic reticulum membrane. Role of the N and C-terminal flanking regions. Journal of Molecular Biology. 313: 1171-9. PMID 11700072 DOI: 10.1006/jmbi.2001.5108  1
2001 Drew DE, von Heijne G, Nordlund P, de Gier JW. Green fluorescent protein as an indicator to monitor membrane protein overexpression in Escherichia coli. Febs Letters. 507: 220-4. PMID 11684102 DOI: 10.1016/S0014-5793(01)02980-5  1
2001 Nilsson I, Ohvo-Rekilä H, Slotte JP, Johnson AE, Von Heijne G. Inhibition of Protein Translocation across the Endoplasmic Reticulum Membrane by Sterols Journal of Biological Chemistry. 276: 41748-41754. PMID 11535595 DOI: 10.1074/jbc.M105823200  1
2001 Emanuelsson O, Von Heijne G, Schneider G. Analysis and prediction of mitochondrial targeting pep tides Methods in Cell Biology. 175-187. PMID 11381593  1
2001 Monné M, Von Heijne G. Effects of 'hydrophobic mismatch' on the location of transmembrane helices in the ER membrane Febs Letters. 496: 96-100. PMID 11356190 DOI: 10.1016/S0014-5793(01)02415-2  1
2001 Sääf A, Baars L, Von Heijne G. The Internal Repeats in the Na+/Ca2+ Exchanger-related Escherichia coli Protein YrbG Have Opposite Membrane Topologies Journal of Biological Chemistry. 276: 18905-18907. PMID 11259419 DOI: 10.1074/jbc.M101716200  1
2001 Krogh A, Larsson B, von Heijne G, Sonnhammer EL. Predicting transmembrane protein topology with a hidden Markov model: application to complete genomes. Journal of Molecular Biology. 305: 567-80. PMID 11152613 DOI: 10.1006/jmbi.2000.4315  1
2000 Mingarro I, Nilsson I, Whitley P, von Heijne G. Different conformations of nascent polypeptides during translocation across the ER membrane Bmc Cell Biology [Electronic Resource]. 1: 3. PMID 11178101 DOI: 10.1186/1471-2121-1-3  1
2000 Nilsson J, Persson B, Von Heijne G. Consensus predictions of membrane protein topology Febs Letters. 486: 267-269. PMID 11119716 DOI: 10.1016/S0014-5793(00)02321-8  1
2000 Chin CN, Von Heijne G. Charge pair interactions, in a model transmembrane helix in the ER membrane Journal of Molecular Biology. 303: 1-5. PMID 11021965 DOI: 10.1006/jmbi.2000.4122  1
2000 Killian JA, von Heijne G. How proteins adapt to a membrane-water interface. Trends in Biochemical Sciences. 25: 429-34. PMID 10973056 DOI: 10.1016/S0968-0004(00)01626-1  1
2000 Sääf A, Hermansson M, von Heijne G. Formation of cytoplasmic turns between two closely spaced transmembrane helices during membrane protein integration into the ER membrane. Journal of Molecular Biology. 301: 191-7. PMID 10926501 DOI: 10.1006/jmbi.2000.3933  1
2000 Emanuelsson O, Nielsen H, Brunak S, Von Heijne G. Predicting subcellular localization of proteins based on their N-terminal amino acid sequence Journal of Molecular Biology. 300: 1005-1016. PMID 10891285 DOI: 10.1006/jmbi.2000.3903  1
2000 Hasler U, Greasley PJ, Von Heijne G, Geering K. Determinants of topogenesis and glycosylation of type II membrane proteins. Analysis of Na,K-ATPase β1 and β3 subunits by glycosylation mapping Journal of Biological Chemistry. 275: 29011-29022. PMID 10887183  1
2000 Nilsson I, Von Heijne G. Glycosylation efficiency of Asn-Xaa-Thr sequons depends both on the distance from the C terminus and on the presence of a downstream transmembrane segment Journal of Biological Chemistry. 275: 17338-17343. PMID 10748070 DOI: 10.1074/jbc.M002317200  1
2000 Nilsson I, Witt S, Kiefer H, Mingarro I, Von Heijne G. Distant downstream sequence determinants can control N-tail translocation during protein insertion into the endoplasmic reticulum membrane Journal of Biological Chemistry. 275: 6207-6213. PMID 10692414 DOI: 10.1074/jbc.275.9.6207  1
2000 Scotti PA, Urbanus ML, Brunner J, De Gier JWL, Von Heijne G, Van Der Does C, Driessen AJM, Oudega B, Luirink J. YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase Embo Journal. 19: 542-549. PMID 10675323  1
2000 Von Heijne G. Transport of peptides and proteins through membranes. Editorial overview Current Opinion in Cell Biology. 12: 399. DOI: 10.1016/S0955-0674(00)00107-1  1
1999 Von Heijne G. Recent advances in the understanding of membrane protein assembly and structure Quarterly Reviews of Biophysics. 32: 285-307. PMID 11194567 DOI: 10.1017/S0033583500003541  1
1999 Armulik A, Nilsson I, Von Heijne G, Johansson S. Determination of the border between the transmembrane and cytoplasmic domains of human integrin subunits Journal of Biological Chemistry. 274: 37030-37034. PMID 10601259 DOI: 10.1074/jbc.274.52.37030  1
1999 Devoto A, Piffanelli P, Nilsson I, Wallin E, Panstruga R, Von Heijne G, Schulze-Lefert P. Topology, subcellular localization, and sequence diversity of the Mlo family in plants Journal of Biological Chemistry. 274: 34993-35004. PMID 10574976 DOI: 10.1074/jbc.274.49.34993  1
1999 Monné M, Nilsson I, Elofsson A, von Heijne G. Turns in transmembrane helices: determination of the minimal length of a "helical hairpin" and derivation of a fine-grained turn propensity scale. Journal of Molecular Biology. 293: 807-14. PMID 10543969 DOI: 10.1006/jmbi.1999.3183  1
1999 Von Heijne G. A day in the life of Dr K. or how I learned to stop worrying and love lysozyme: A tragedy in six acts Journal of Molecular Biology. 293: 367-379. PMID 10529351 DOI: 10.1006/jmbi.1999.2998  1
1999 Monné M, Gafvelin G, Nilsson R, von Heijne G. N-tail translocation in a eukaryotic polytopic membrane protein. Synergy between neighboring transmembrane segments European Journal of Biochemistry. 263: 264-269. PMID 10429212 DOI: 10.1046/j.1432-1327.1999.00498.x  1
1999 Braun P, Von Heijne G. The aromatic residues Trp and phe have different effects on the positioning of a transmembrane helix in the microsomal membrane Biochemistry. 38: 9778-9782. PMID 10423258 DOI: 10.1021/bi990923a  1
1999 Sääf A, Johansson M, Wallin E, Von Heijne G. Divergent evolution of membrane protein topology: The Escherichia coli RnfA and RnfE homologues Proceedings of the National Academy of Sciences of the United States of America. 96: 8540-8544. PMID 10411911 DOI: 10.1073/pnas.96.15.8540  1
1999 Cristóbal S, Scotti P, Luirink J, Von Heijne G, De Gier JWL. The signal recognition particle-targeting pathway does not necessarily deliver proteins to the Sec-translocase in Escherichia coli Journal of Biological Chemistry. 274: 20068-20070. PMID 10400614 DOI: 10.1074/jbc.274.29.20068  1
1999 Cristóbal S, De Gier JW, Nielsen H, Von Heijne G. Competition between Sec- and TAT-dependent protein translocation in Escherichia coli Embo Journal. 18: 2982-2990. PMID 10357811 DOI: 10.1093/emboj/18.11.2982  1
1999 Emanuelsson O, Nielsen H, Von Heijne G. ChloroP, a neural network-based method for predicting chloroplast transit peptides and their cleavage sites Protein Science. 8: 978-984. PMID 10338008  1
1999 Monné M, Hermansson M, von Heijne G. A turn propensity scale for transmembrane helices. Journal of Molecular Biology. 288: 141-5. PMID 10329132 DOI: 10.1006/jmbi.1999.2657  1
1999 Nielsen H, Brunak S, Von Heijne G. Machine learning approaches for the prediction of signal peptides and other protein sorting signals Protein Engineering. 12: 3-9. PMID 10065704  1
1999 Van Geest M, Nilsson I, Von Heijne G, Lolkema JS. Insertion of a bacterial secondary transport protein in the endoplasmic reticulum membrane Journal of Biological Chemistry. 274: 2816-2823. PMID 9915815 DOI: 10.1074/jbc.274.5.2816  1
1998 De Gier JWL, Scotti PA, Sääf A, Valent QA, Kuhn A, Luirink J, Von Heijne G. Differential use of the signal recognition particle translocase targeting pathway for inner membrane protein assembly in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 95: 14646-14651. PMID 9843943 DOI: 10.1073/pnas.95.25.14646  1
1998 Nilsson I, Von Heijne G. Breaking the camel's back: Proline-induced turns in a model transmembrane helix Journal of Molecular Biology. 284: 1185-1189. PMID 9837736 DOI: 10.1006/jmbi.1998.2219  1
1998 Monné M, Nilsson I, Johansson M, Elmhed N, Von Heijne G. Positively and negatively charged residues have different effects on the position in the membrane of a model transmembrane helix Journal of Molecular Biology. 284: 1177-1183. PMID 9837735 DOI: 10.1006/jmbi.1998.2218  1
1998 Nilsson I, Sääf A, Whitley P, Gafvelin G, Waller C, Von Heijne G. Proline-induced disruption of a transmembrane α-helix in its natural environment Journal of Molecular Biology. 284: 1165-1175. PMID 9837734 DOI: 10.1006/jmbi.1998.2217  1
1998 Ota K, Sakaguchi M, Von Heijne G, Hamasaki N, Mihara K. Forced transmembrane orientation of hydrophilic polypeptide segments in multispanning membrane proteins Molecular Cell. 2: 495-503. PMID 9809071  1
1998 Sääf A, Monné M, De Gier JW, Von Heijne G. Membrane topology of the 60-kDa Oxa1p homologue from Escherichia coli Journal of Biological Chemistry. 273: 30415-30418. PMID 9804807 DOI: 10.1074/jbc.273.46.30415  1
1998 Von Heijne G. Structural aspects of transmembrane α-helices Acta Physiologica Scandinavica, Supplement. 163: 17-19. PMID 9789543  1
1998 Sonnhammer EL, von Heijne G, Krogh A. A hidden Markov model for predicting transmembrane helices in protein sequences. Proceedings / ... International Conference On Intelligent Systems For Molecular Biology ; Ismb. International Conference On Intelligent Systems For Molecular Biology. 6: 175-82. PMID 9783223  1
1998 Seshadri K, Garemyr R, Wallin E, von Heijne G, Elofsson A. Architecture of beta-barrel membrane proteins: analysis of trimeric porins. Protein Science : a Publication of the Protein Society. 7: 2026-32. PMID 9761484 DOI: 10.1002/pro.5560070919  1
1998 van Klompenburg W, Paetzel M, de Jong JM, Dalbey RE, Demel RA, von Heijne G, de Kruijff B. Phosphatidylethanolamine mediates insertion of the catalytic domain of leader peptidase in membranes. Febs Letters. 431: 75-9. PMID 9684869 DOI: 10.1016/S0014-5793(98)00733-9  1
1998 Wallin E, Von Heijne G. Genome-wide analysis of integral membrane proteins from eubacterial, archaean, and eukaryotic organisms Protein Science. 7: 1029-1038. PMID 9568909  1
1998 Valent QA, Scotti PA, High S, De Gier JWL, Von Heijne G, Lentzen G, Wintermeyer W, Oudega B, Luirink J. The Escherichia coli SRP and SecB targeting pathways converge at the translocon Embo Journal. 17: 2504-2512. PMID 9564033 DOI: 10.1093/emboj/17.9.2504  1
1998 Sääf A, Wallin E, Von Heijne G. Stop-transfer function of pseudo-random amino acid segments during translocation across prokaryotic and eukaryotic membranes European Journal of Biochemistry. 251: 821-829. PMID 9490057  1
1998 Schneider G, Sjöling S, Wallin E, Wrede P, Glaser E, Von Heijne G. Feature-extraction from endopeptidase cleavage sites in mitochondrial targeting peptides Proteins: Structure, Function and Genetics. 30: 49-60. PMID 9443340 DOI: 10.1002/(SICI)1097-0134(19980101)30:1<49::AID-PROT5>3.0.CO;2-F  1
1997 Nielsen H, Engelbrecht J, Brunak S, von Heijne G. A neural network method for identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites International Journal of Neural Systems. 8: 581-599. PMID 10065837  1
1997 Braun P, Persson B, Kaback HR, Von Heijne G. Alanine insertion scanning mutagenesis of lactose permease transmembrane helices Journal of Biological Chemistry. 272: 29566-29571. PMID 9368019 DOI: 10.1074/jbc.272.47.29566  1
1997 Mingarro I, Elofsson A, von Heijne G. Helix-helix packing in a membrane-like environment. Journal of Molecular Biology. 272: 633-41. PMID 9325117 DOI: 10.1006/jmbi.1997.1276  1
1997 Cserzö M, Wallin E, Simon I, von Heijne G, Elofsson A. Prediction of transmembrane alpha-helices in prokaryotic membrane proteins: the dense alignment surface method. Protein Engineering. 10: 673-6. PMID 9278280  1
1997 Wallin E, Tsukihara T, Yoshikawa S, von Heijne G, Elofsson A. Architecture of helix bundle membrane proteins: an analysis of cytochrome c oxidase from bovine mitochondria. Protein Science : a Publication of the Protein Society. 6: 808-15. PMID 9098890 DOI: 10.1002/pro.5560060407  1
1988 von Heijne G, Wickner W, Dalbey RE. The cytoplasmic domain of Escherichia coli leader peptidase is a "translocation poison" sequence. Proceedings of the National Academy of Sciences of the United States of America. 85: 3363-6. PMID 3285342  1
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