Year |
Citation |
Score |
2023 |
Pelletier D, Rath A, Sabbaghian N, Pelmus M, Hudon C, Jacob K, Witowski L, Saskin A, Heinen CD, Foulkes WD. Functional and phenotypic consequences of an unusual inversion in MSH2. Familial Cancer. PMID 37957483 DOI: 10.1007/s10689-023-00350-3 |
0.409 |
|
2022 |
Madden-Hennessey K, Gupta D, Radecki AA, Guild C, Rath A, Heinen CD. Loss of mismatch repair promotes a direct selective advantage in human stem cells. Stem Cell Reports. 17: 2661-2673. PMID 36368329 DOI: 10.1016/j.stemcr.2022.10.009 |
0.396 |
|
2022 |
Rath A, Radecki AA, Rahman K, Gilmore RB, Hudson JR, Cenci M, Tavtigian SV, Grady JP, Heinen CD. A calibrated cell-based functional assay to aid classification of MLH1 DNA mismatch repair gene variants. Human Mutation. PMID 36054288 DOI: 10.1002/humu.24462 |
0.437 |
|
2019 |
Brnich SE, Abou Tayoun AN, Couch FJ, Cutting GR, Greenblatt MS, Heinen CD, Kanavy DM, Luo X, McNulty SM, Starita LM, Tavtigian SV, Wright MW, Harrison SM, Biesecker LG, Berg JS, et al. Recommendations for application of the functional evidence PS3/BS3 criterion using the ACMG/AMP sequence variant interpretation framework. Genome Medicine. 12: 3. PMID 31892348 DOI: 10.1186/S13073-019-0690-2 |
0.305 |
|
2019 |
Taghbalout A, Du M, Jillette N, Rosikiewicz W, Rath A, Heinen CD, Li S, Cheng AW. Enhanced CRISPR-based DNA demethylation by Casilio-ME-mediated RNA-guided coupling of methylcytosine oxidation and DNA repair pathways. Nature Communications. 10: 4296. PMID 31541098 DOI: 10.1038/S41467-019-12339-7 |
0.445 |
|
2019 |
Rath A, Mishra A, Ferreira VD, Hu C, Omerza G, Kelly K, Hesse A, Reddi HV, Grady JP, Heinen CD. Functional Interrogation of Lynch Syndrome Associated MSH2 Missense Variants via CRISPR-Cas9 Gene Editing in Human Embryonic Stem Cells. Human Mutation. PMID 31237724 DOI: 10.1002/Humu.23848 |
0.571 |
|
2019 |
Gupta D, Heinen CD. The mismatch repair-dependent DNA damage response: Mechanisms and implications. Dna Repair. 78: 60-69. PMID 30959407 DOI: 10.1016/J.Dnarep.2019.03.009 |
0.631 |
|
2018 |
Gupta D, Lin B, Cowan A, Heinen CD. ATR-Chk1 activation mitigates replication stress caused by mismatch repair-dependent processing of DNA damage. Proceedings of the National Academy of Sciences of the United States of America. PMID 29378956 DOI: 10.1073/Pnas.1720355115 |
0.628 |
|
2017 |
Lin B, Yang Q, Rath A, Heinen CD. Abstract 1411: Differential mismatch repair-dependent damage responses in subpopulations of cells from human intestinal organoids Cancer Research. 77: 1411-1411. DOI: 10.1158/1538-7445.Am2017-1411 |
0.432 |
|
2016 |
Klapacz J, Pottenger LH, Engelward BP, Heinen CD, Johnson GE, Clewell RA, Carmichael PL, Adeleye Y, Andersen ME. Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents. Mutation Research. Reviews in Mutation Research. 767: 77-91. PMID 27036068 DOI: 10.1016/J.Mrrev.2015.11.001 |
0.59 |
|
2016 |
Fishel R, Heinen CD. Enhanced gene targeting to evaluate Lynch syndrome alterations. Proceedings of the National Academy of Sciences of the United States of America. PMID 27035997 DOI: 10.1073/Pnas.1602650113 |
0.488 |
|
2016 |
Heinen CD. Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer. Dna Repair. 38: 127-34. PMID 26710976 DOI: 10.1016/J.Dnarep.2015.11.025 |
0.461 |
|
2015 |
Lynch HT, Snyder CL, Shaw TG, Heinen CD, Hitchins MP. Milestones of Lynch syndrome: 1895-2015. Nature Reviews. Cancer. 15: 181-94. PMID 25673086 DOI: 10.1038/Nrc3878 |
0.365 |
|
2015 |
Klapacz J, Pottenger LH, Engelward BP, Heinen CD, Johnson GE, Clewell RA, Carmichael PL, Adeleye Y, Andersen ME. Contributions of DNA repair and damage response pathways to the non-linear genotoxic responses of alkylating agents Mutation Research - Reviews in Mutation Research. DOI: 10.1016/j.mrrev.2015.11.001 |
0.415 |
|
2014 |
Lin B, Gupta D, Heinen CD. Human pluripotent stem cells have a novel mismatch repair-dependent damage response. The Journal of Biological Chemistry. 289: 24314-24. PMID 25012654 DOI: 10.1074/Jbc.M114.570937 |
0.62 |
|
2014 |
Heinen CD. Translating mismatch repair mechanism into cancer care. Current Drug Targets. 15: 53-64. PMID 24387335 DOI: 10.2174/1389450114666140106100128 |
0.482 |
|
2014 |
Thompson BA, Spurdle AB, Plazzer JP, Greenblatt MS, Akagi K, Al-Mulla F, Bapat B, Bernstein I, Capellá G, den Dunnen JT, du Sart D, Fabre A, Farrell MP, Farrington SM, Frayling IM, ... ... Heinen CD, et al. Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database. Nature Genetics. 46: 107-15. PMID 24362816 DOI: 10.1038/Ng.2854 |
0.315 |
|
2013 |
Rasmussen LJ, Heinen CD, Royer-Pokora B, Drost M, Tavtigian S, Hofstra RM, de Wind N. Response to: Design of a core classification process for DNA mismatch repair variations of a priori unknown functional significance. Human Mutation. 34: 923-4. PMID 23554108 DOI: 10.1002/Humu.22310 |
0.519 |
|
2012 |
Rasmussen LJ, Heinen CD, Royer-Pokora B, Drost M, Tavtigian S, Hofstra RM, de Wind N. Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future. Human Mutation. 33: 1617-25. PMID 22833534 DOI: 10.1002/Humu.22168 |
0.431 |
|
2012 |
Heinen CD, Juel Rasmussen L. Determining the functional significance of mismatch repair gene missense variants using biochemical and cellular assays. Hereditary Cancer in Clinical Practice. 10: 9. PMID 22824075 DOI: 10.1186/1897-4287-10-9 |
0.491 |
|
2012 |
Cyr JL, Brown GD, Stroop J, Heinen CD. The predicted truncation from a cancer-associated variant of the MSH2 initiation codon alters activity of the MSH2-MSH6 mismatch repair complex. Molecular Carcinogenesis. 51: 647-58. PMID 21837758 DOI: 10.1002/Mc.20838 |
0.546 |
|
2011 |
Mohni KN, Mastrocola AS, Bai P, Weller SK, Heinen CD. DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication. Journal of Virology. 85: 12241-53. PMID 21957315 DOI: 10.1128/Jvi.05487-11 |
0.686 |
|
2011 |
Heinen CD, Cyr JL, Cook C, Punja N, Sakato M, Forties RA, Lopez JM, Hingorani MM, Fishel R. Human MSH2 (hMSH2) protein controls ATP processing by hMSH2-hMSH6. The Journal of Biological Chemistry. 286: 40287-95. PMID 21937421 DOI: 10.1074/Jbc.M111.297523 |
0.353 |
|
2011 |
Hollenbach JP, Resch AM, Palakodeti D, Graveley BR, Heinen CD. Loss of DNA mismatch repair imparts a selective advantage in planarian adult stem cells. Plos One. 6: e21808. PMID 21747960 DOI: 10.1371/Journal.Pone.0021808 |
0.752 |
|
2010 |
Mastrocola AS, Heinen CD. Lynch syndrome-associated mutations in MSH2 alter DNA repair and checkpoint response functions in vivo. Human Mutation. 31: E1699-708. PMID 20672385 DOI: 10.1002/Humu.21333 |
0.714 |
|
2010 |
Mastrocola AS, Heinen CD. Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage. Dna Repair. 9: 120-33. PMID 20004149 DOI: 10.1016/J.Dnarep.2009.11.003 |
0.706 |
|
2010 |
Heinen CD. Genotype to phenotype: analyzing the effects of inherited mutations in colorectal cancer families. Mutation Research. 693: 32-45. PMID 19766128 DOI: 10.1016/J.Mrfmmm.2009.09.004 |
0.379 |
|
2008 |
Cyr JL, Heinen CD. Hereditary cancer-associated missense mutations in hMSH6 uncouple ATP hydrolysis from DNA mismatch binding. The Journal of Biological Chemistry. 283: 31641-8. PMID 18790734 DOI: 10.1074/Jbc.M806018200 |
0.509 |
|
2007 |
Rosenberg DW, Yang S, Pleau DC, Greenspan EJ, Stevens RG, Rajan TV, Heinen CD, Levine J, Zhou Y, O'Brien MJ. Mutations in BRAF and KRAS differentially distinguish serrated versus non-serrated hyperplastic aberrant crypt foci in humans. Cancer Research. 67: 3551-4. PMID 17440063 DOI: 10.1158/0008-5472.Can-07-0343 |
0.351 |
|
2007 |
Greenspan EJ, Cyr JL, Pleau DC, Levine J, Rajan TV, Rosenberg DW, Heinen CD. Microsatellite instability in aberrant crypt foci from patients without concurrent colon cancer. Carcinogenesis. 28: 769-76. PMID 17088260 DOI: 10.1093/Carcin/Bgl209 |
0.367 |
|
2004 |
Shim KS, Schmutte C, Tombline G, Heinen CD, Fishel R. hXRCC2 enhances ADP/ATP processing and strand exchange by hRAD51. The Journal of Biological Chemistry. 279: 30385-94. PMID 15123651 DOI: 10.1074/Jbc.M306066200 |
0.47 |
|
2003 |
Fishel R, Acharya S, Berardini M, Bocker T, Charbonneau N, Cranston A, Gradia S, Guerrette S, Heinen CD, Mazurek A, Snowden T, Schmutte C, Shim KS, Tombline G, Wilson T. Signaling mismatch repair: the mechanics of an adenosine-nucleotide molecular switch. Cold Spring Harbor Symposia On Quantitative Biology. 65: 217-24. PMID 12760035 DOI: 10.1101/Sqb.2000.65.217 |
0.314 |
|
2002 |
Heinen CD, Schmutte C, Fishel R. DNA repair and tumorigenesis: lessons from hereditary cancer syndromes. Cancer Biology & Therapy. 1: 477-85. PMID 12496472 DOI: 10.4161/Cbt.1.5.160 |
0.615 |
|
2002 |
Heinen CD, Goss KH, Cornelius JR, Babcock GF, Knudsen ES, Kowalik T, Groden J. The APC tumor suppressor controls entry into S-phase through its ability to regulate the cyclin D/RB pathway. Gastroenterology. 123: 751-63. PMID 12198702 DOI: 10.1053/Gast.2002.35382 |
0.343 |
|
2002 |
Heinen CD, Wilson T, Mazurek A, Berardini M, Butz C, Fishel R. HNPCC mutations in hMSH2 result in reduced hMSH2-hMSH6 molecular switch functions. Cancer Cell. 1: 469-78. PMID 12124176 DOI: 10.1016/S1535-6108(02)00073-9 |
0.437 |
|
2002 |
Tombline G, Heinen CD, Shim KS, Fishel R. Biochemical characterization of the human RAD51 protein. III. Modulation of DNA binding by adenosine nucleotides. The Journal of Biological Chemistry. 277: 14434-42. PMID 11839741 DOI: 10.1074/Jbc.M109917200 |
0.44 |
|
1997 |
Heinen CD, Noffsinger AE, Belli J, Straughen J, Fischer J, Groden J, Fenoglio-Preiser CM. Regenerative lesions in ulcerative colitis are characterized by microsatellite mutation Genes Chromosomes and Cancer. 19: 170-175. PMID 9218998 DOI: 10.1002/(Sici)1098-2264(199707)19:3<170::Aid-Gcc6>3.0.Co;2-V |
0.521 |
|
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