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Year Citation  Score
2017 Quinn WJ, Wan M, Shewale SV, Gelfer R, Rader DJ, Birnbaum MJ, Titchenell PM. mTORC1 stimulates phosphatidylcholine synthesis to promote triglyceride secretion. The Journal of Clinical Investigation. PMID 29035283 DOI: 10.1172/JCI96036  0.88
2017 Titchenell PM, Lazar MA, Birnbaum MJ. Unraveling the Regulation of Hepatic Metabolism by Insulin. Trends in Endocrinology and Metabolism: Tem. PMID 28416361 DOI: 10.1016/j.tem.2017.03.003  0.88
2016 Shearin AL, Monks BR, Seale P, Birnbaum MJ. Lack of AKT in adipocytes causes severe lipodystrophy. Molecular Metabolism. 5: 472-9. PMID 27408773 DOI: 10.1016/j.molmet.2016.05.006  0.88
2016 Titchenell PM, Quinn WJ, Lu M, Chu Q, Lu W, Li C, Chen H, Monks BR, Chen J, Rabinowitz JD, Birnbaum MJ. Direct Hepatocyte Insulin Signaling Is Required for Lipogenesis but Is Dispensable for the Suppression of Glucose Production. Cell Metabolism. PMID 27238637 DOI: 10.1016/j.cmet.2016.04.022  0.88
2015 Chen Q, Lu M, Monks BR, Birnbaum MJ. Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1. The Journal of Biological Chemistry. PMID 26668316 DOI: 10.1074/jbc.M115.677351  0.88
2015 Zhang Z, Amorosa LF, Coyle SM, Macor MA, Lubitz SE, Carson JL, Birnbaum MJ, Lee LY, Haimovich B. Proteolytic Cleavage of AMPKα and Intracellular MMP9 Expression Are Both Required for TLR4-Mediated mTORC1 Activation and HIF-1α Expression in Leukocytes. Journal of Immunology (Baltimore, Md. : 1950). PMID 26232429 DOI: 10.4049/jimmunol.1500944  0.88
2015 Feng D, Youn DY, Zhao X, Gao Y, Quinn WJ, Xiaoli AM, Sun Y, Birnbaum MJ, Pessin JE, Yang F. mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). Plos One. 10: e0126240. PMID 26042770 DOI: 10.1371/journal.pone.0126240  0.88
2015 DiPilato LM, Ahmad F, Harms M, Seale P, Manganiello V, Birnbaum MJ. The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin. Molecular and Cellular Biology. 35: 2752-60. PMID 26031333 DOI: 10.1128/MCB.00422-15  0.88
2015 Xie Y, Jin Y, Merenick BL, Ding M, Fetalvero KM, Wagner RJ, Mai A, Gleim S, Tucker DF, Birnbaum MJ, Ballif BA, Luciano AK, Sessa WC, Rzucidlo EM, Powell RJ, et al. Phosphorylation of GATA-6 is required for vascular smooth muscle cell differentiation after mTORC1 inhibition. Science Signaling. 8: ra44. PMID 25969542 DOI: 10.1126/scisignal.2005482  0.88
2015 Titchenell PM, Chu Q, Monks BR, Birnbaum MJ. Hepatic insulin signalling is dispensable for suppression of glucose output by insulin in vivo. Nature Communications. 6: 7078. PMID 25963408 DOI: 10.1038/ncomms8078  0.88
2015 Koren S, DiPilato LM, Emmett MJ, Shearin AL, Chu Q, Monks B, Birnbaum MJ. The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo. Diabetologia. 58: 1063-70. PMID 25740694 DOI: 10.1007/s00125-015-3532-9  0.88
2015 Weljie AM, Meerlo P, Goel N, Sengupta A, Kayser MS, Abel T, Birnbaum MJ, Dinges DF, Sehgal A. Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt. Proceedings of the National Academy of Sciences of the United States of America. 112: 2569-74. PMID 25675494 DOI: 10.1073/pnas.1417432112  0.88
2015 Perry RJ, Camporez JP, Kursawe R, Titchenell PM, Zhang D, Perry CJ, Jurczak MJ, Abudukadier A, Han MS, Zhang XM, Ruan HB, Yang X, Caprio S, Kaech SM, Sul HS, ... Birnbaum MJ, et al. Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes. Cell. 160: 745-58. PMID 25662011 DOI: 10.1016/j.cell.2015.01.012  0.88
2014 Cannon CE, Titchenell PM, Groff DN, El Ouaamari A, Kulkarni RN, Birnbaum MJ, Stoffers DA. The Polycomb protein, Bmi1, regulates insulin sensitivity. Molecular Metabolism. 3: 794-802. PMID 25379404 DOI: 10.1016/j.molmet.2014.08.002  0.88
2014 Koral K, Li H, Ganesh N, Birnbaum MJ, Hallows KR, Erkan E. Akt recruits Dab2 to albumin endocytosis in the proximal tubule. American Journal of Physiology. Renal Physiology. 307: F1380-9. PMID 25253241 DOI: 10.1152/ajprenal.00454.2014  0.88
2014 Baur JA, Birnbaum MJ. Control of gluconeogenesis by metformin: does redox trump energy charge? Cell Metabolism. 20: 197-9. PMID 25100057 DOI: 10.1016/j.cmet.2014.07.013  0.88
2014 Patel K, Foretz M, Marion A, Campbell DG, Gourlay R, Boudaba N, Tournier E, Titchenell P, Peggie M, Deak M, Wan M, Kaestner KH, Göransson O, Viollet B, Gray NS, ... Birnbaum MJ, et al. The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nature Communications. 5: 4535. PMID 25088745 DOI: 10.1038/ncomms5535  0.88
2014 O'Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL. Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity. 41: 75-88. PMID 25001241 DOI: 10.1016/j.immuni.2014.06.005  0.88
2013 Rastogi R, Jiang Z, Ahmad N, Rosati R, Liu Y, Beuret L, Monks R, Charron J, Birnbaum MJ, Samavati L. Rapamycin induces mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) expression through activation of protein kinase B and mitogen-activated protein kinase kinase pathways. The Journal of Biological Chemistry. 288: 33966-77. PMID 24126911 DOI: 10.1074/jbc.M113.492702  0.88
2013 Wan M, Leavens KF, Hunter RW, Koren S, von Wilamowitz-Moellendorff A, Lu M, Satapati S, Chu Q, Sakamoto K, Burgess SC, Birnbaum MJ. A noncanonical, GSK3-independent pathway controls postprandial hepatic glycogen deposition. Cell Metabolism. 18: 99-105. PMID 23823480 DOI: 10.1016/j.cmet.2013.06.001  0.88
2013 Kim JS, Sklarz T, Banks LB, Gohil M, Waickman AT, Skuli N, Krock BL, Luo CT, Hu W, Pollizzi KN, Li MO, Rathmell JC, Birnbaum MJ, Powell JD, Jordan MS, et al. Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways. Nature Immunology. 14: 611-8. PMID 23644504 DOI: 10.1038/ni.2607  0.88
2013 Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, ... ... Birnbaum MJ, et al. Construction of human activity-based phosphorylation networks. Molecular Systems Biology. 9: 655. PMID 23549483 DOI: 10.1038/msb.2013.12  0.88
2013 Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature. 494: 256-60. PMID 23292513 DOI: 10.1038/nature11808  0.88
2012 Mallilankaraman K, Doonan P, Cárdenas C, Chandramoorthy HC, Müller M, Miller R, Hoffman NE, Gandhirajan RK, Molgó J, Birnbaum MJ, Rothberg BS, Mak DO, Foskett JK, Madesh M. MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival. Cell. 151: 630-44. PMID 23101630 DOI: 10.1016/j.cell.2012.10.011  0.88
2012 Quinn WJ, Birnbaum MJ. Distinct mTORC1 pathways for transcription and cleavage of SREBP-1c. Proceedings of the National Academy of Sciences of the United States of America. 109: 15974-5. PMID 23012450 DOI: 10.1073/pnas.1214113109  0.88
2012 Sassu ED, McDermott JE, Keys BJ, Esmaeili M, Keene AC, Birnbaum MJ, DiAngelo JR. Mio/dChREBP coordinately increases fat mass by regulating lipid synthesis and feeding behavior in Drosophila. Biochemical and Biophysical Research Communications. 426: 43-8. PMID 22910416 DOI: 10.1016/j.bbrc.2012.08.028  0.88
2012 Treins C, Alliouachene S, Hassouna R, Xie Y, Birnbaum MJ, Pende M. The combined deletion of S6K1 and Akt2 deteriorates glycemic control in a high-fat diet. Molecular and Cellular Biology. 32: 4001-11. PMID 22851690 DOI: 10.1128/MCB.00514-12  0.88
2012 Lazar MA, Birnbaum MJ. Physiology. De-meaning of metabolism. Science (New York, N.Y.). 336: 1651-2. PMID 22745413 DOI: 10.1126/science.1221834  0.88
2012 Sun Z, Miller RA, Patel RT, Chen J, Dhir R, Wang H, Zhang D, Graham MJ, Unterman TG, Shulman GI, Sztalryd C, Bennett MJ, Ahima RS, Birnbaum MJ, Lazar MA. Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nature Medicine. 18: 934-42. PMID 22561686 DOI: 10.1038/nm.2744  0.88
2012 Lu M, Wan M, Leavens KF, Chu Q, Monks BR, Fernandez S, Ahima RS, Ueki K, Kahn CR, Birnbaum MJ. Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Nature Medicine. 18: 388-95. PMID 22344295 DOI: 10.1038/nm.2686  0.88
2012 Panasyuk G, Espeillac C, Chauvin C, Pradelli LA, Horie Y, Suzuki A, Annicotte JS, Fajas L, Foretz M, Verdeguer F, Pontoglio M, Ferré P, Scoazec JY, Birnbaum MJ, Ricci JE, et al. PPARγ contributes to PKM2 and HK2 expression in fatty liver. Nature Communications. 3: 672. PMID 22334075 DOI: 10.1038/ncomms1667  0.88
2012 Bauerfeld CP, Rastogi R, Pirockinaite G, Lee I, Hüttemann M, Monks B, Birnbaum MJ, Franchi L, Nuñez G, Samavati L. TLR4-mediated AKT activation is MyD88/TRIF dependent and critical for induction of oxidative phosphorylation and mitochondrial transcription factor A in murine macrophages. Journal of Immunology (Baltimore, Md. : 1950). 188: 2847-57. PMID 22312125 DOI: 10.4049/jimmunol.1102157  0.88
2012 Wan M, Easton RM, Gleason CE, Monks BR, Ueki K, Kahn CR, Birnbaum MJ. Loss of Akt1 in mice increases energy expenditure and protects against diet-induced obesity. Molecular and Cellular Biology. 32: 96-106. PMID 22037765 DOI: 10.1128/MCB.05806-11  0.88
2012 Chatterjee S, Browning EA, Hong N, DeBolt K, Sorokina EM, Liu W, Birnbaum MJ, Fisher AB. Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS. American Journal of Physiology. Heart and Circulatory Physiology. 302: H105-14. PMID 22003059 DOI: 10.1152/ajpheart.00298.2011  0.88
2012 Balu DT, Carlson GC, Talbot K, Kazi H, Hill-Smith TE, Easton RM, Birnbaum MJ, Lucki I. Akt1 deficiency in schizophrenia and impairment of hippocampal plasticity and function. Hippocampus. 22: 230-40. PMID 21049487 DOI: 10.1002/hipo.20887  0.88
2012 Birnbaum MJ. Skeletal muscle metabolism Muscle. 2: 841-853. DOI: 10.1016/B978-0-12-381510-1.00059-4  0.88
2011 Wan M, Birnbaum MJ. Of mice and men: not ExAKTly the same? Cell Metabolism. 14: 722-3. PMID 22152300 DOI: 10.1016/j.cmet.2011.11.009  0.88
2011 Wan M, Leavens KF, Saleh D, Easton RM, Guertin DA, Peterson TR, Kaestner KH, Sabatini DM, Birnbaum MJ. Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c. Cell Metabolism. 14: 516-27. PMID 21982711 DOI: 10.1016/j.cmet.2011.09.001  0.88
2011 Yao LJ, McCormick JA, Wang J, Yang KY, Kidwai A, Colussi GL, Boini KM, Birnbaum MJ, Lang F, German MS, Pearce D. Novel role for SGK3 in glucose homeostasis revealed in SGK3/Akt2 double-null mice. Molecular Endocrinology (Baltimore, Md.). 25: 2106-18. PMID 21980074 DOI: 10.1210/me.2010-0329  0.88
2011 Bland ML, Birnbaum MJ. Cell biology. ADaPting to energetic stress. Science (New York, N.Y.). 332: 1387-8. PMID 21680830 DOI: 10.1126/science.1208444  0.88
2011 Miller RA, Chu Q, Le Lay J, Scherer PE, Ahima RS, Kaestner KH, Foretz M, Viollet B, Birnbaum MJ. Adiponectin suppresses gluconeogenic gene expression in mouse hepatocytes independent of LKB1-AMPK signaling. The Journal of Clinical Investigation. 121: 2518-28. PMID 21606593 DOI: 10.1172/JCI45942  0.88
2011 Leavens KF, Birnbaum MJ. Insulin signaling to hepatic lipid metabolism in health and disease. Critical Reviews in Biochemistry and Molecular Biology. 46: 200-15. PMID 21599535 DOI: 10.3109/10409238.2011.562481  0.88
2011 Birnbaum MJ, Shaw RJ. Genomics: Drugs, diabetes and cancer. Nature. 470: 338-9. PMID 21331030 DOI: 10.1038/470338a  0.88
2011 Holland WL, Miller RA, Wang ZV, Sun K, Barth BM, Bui HH, Davis KE, Bikman BT, Halberg N, Rutkowski JM, Wade MR, Tenorio VM, Kuo MS, Brozinick JT, Zhang BB, ... Birnbaum MJ, et al. Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nature Medicine. 17: 55-63. PMID 21186369 DOI: 10.1038/nm.2277  0.88
2011 Tokuda S, Mahaffey CL, Monks B, Faulkner CR, Birnbaum MJ, Danzer SC, Frankel WN. A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice. Human Molecular Genetics. 20: 988-99. PMID 21159799 DOI: 10.1093/hmg/ddq544  0.88
2010 Liu J, Wang Y, Birnbaum MJ, Stoffers DA. Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1. Proceedings of the National Academy of Sciences of the United States of America. 107: 20494-9. PMID 21059917 DOI: 10.1073/pnas.1007001107  0.88
2010 Goncalves MD, Pistilli EE, Balduzzi A, Birnbaum MJ, Lachey J, Khurana TS, Ahima RS. Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition. Plos One. 5: e12707. PMID 20856813 DOI: 10.1371/journal.pone.0012707  0.88
2010 Chen CC, Boxer RB, Stairs DB, Portocarrero CP, Horton RH, Alvarez JV, Birnbaum MJ, Chodosh LA. Akt is required for Stat5 activation and mammary differentiation. Breast Cancer Research : Bcr. 12: R72. PMID 20849614 DOI: 10.1186/bcr2640  0.88
2010 Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles BL. Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology. 139: 2170-82. PMID 20837017 DOI: 10.1053/j.gastro.2010.09.002  0.88
2010 Choi SM, Tucker DF, Gross DN, Easton RM, DiPilato LM, Dean AS, Monks BR, Birnbaum MJ. Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway. Molecular and Cellular Biology. 30: 5009-20. PMID 20733001 DOI: 10.1128/MCB.00797-10  0.88
2010 Guha M, Fang JK, Monks R, Birnbaum MJ, Avadhani NG. Activation of Akt is essential for the propagation of mitochondrial respiratory stress signaling and activation of the transcriptional coactivator heterogeneous ribonucleoprotein A2. Molecular Biology of the Cell. 21: 3578-89. PMID 20719961 DOI: 10.1091/mbc.E10-03-0192  0.88
2010 Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cell. 142: 270-83. PMID 20655468 DOI: 10.1016/j.cell.2010.06.007  0.88
2010 Hamamdzic D, Fenning RS, Patel D, Mohler ER, Orlova KA, Wright AC, Llano R, Keane MG, Shannon RP, Birnbaum MJ, Wilensky RL. Akt pathway is hypoactivated by synergistic actions of diabetes mellitus and hypercholesterolemia resulting in advanced coronary artery disease. American Journal of Physiology. Heart and Circulatory Physiology. 299: H699-706. PMID 20601459 DOI: 10.1152/ajpheart.00071.2010  0.88
2010 Miller RA, Birnbaum MJ. An energetic tale of AMPK-independent effects of metformin. The Journal of Clinical Investigation. 120: 2267-70. PMID 20577046 DOI: 10.1172/JCI43661  0.88
2010 Rotte A, Pasham V, Bhandaru M, Eichenmüller M, Yang W, Qadri SM, Kempe DS, Puchchakayala G, Pearce D, Birnbaum MJ, Lang F. Regulation of gastric acid secretion by PKB/Akt2. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 25: 695-704. PMID 20511715 DOI: 10.1159/000315089  0.88
2010 Bland ML, Lee RJ, Magallanes JM, Foskett JK, Birnbaum MJ. AMPK supports growth in Drosophila by regulating muscle activity and nutrient uptake in the gut. Developmental Biology. 344: 293-303. PMID 20478298 DOI: 10.1016/j.ydbio.2010.05.010  0.88
2010 Juntilla MM, Patil VD, Calamito M, Joshi RP, Birnbaum MJ, Koretzky GA. AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species. Blood. 115: 4030-8. PMID 20354168 DOI: 10.1182/blood-2009-09-241000  0.88
2010 He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y, Yang J, Wu H, Birnbaum MJ, Stiles BL. The critical role of AKT2 in hepatic steatosis induced by PTEN loss. The American Journal of Pathology. 176: 2302-8. PMID 20348245 DOI: 10.2353/ajpath.2010.090931  0.88
2010 Kempe DS, Ackermann TF, Boini KM, Klaus F, Umbach AT, Dërmaku-Sopjani M, Judenhofer MS, Pichler BJ, Capuano P, Stange G, Wagner CA, Birnbaum MJ, Pearce D, Föller M, Lang F. Akt2/PKBbeta-sensitive regulation of renal phosphate transport. Acta Physiologica (Oxford, England). 200: 75-85. PMID 20236253 DOI: 10.1111/j.1748-1716.2010.02109.x  0.88
2010 Kempe DS, Siraskar G, Fröhlich H, Umbach AT, Stübs M, Weiss F, Ackermann TF, Völkl H, Birnbaum MJ, Pearce D, Föller M, Lang F. Regulation of renal tubular glucose reabsorption by Akt2/PKBβ. American Journal of Physiology. Renal Physiology. 298: F1113-7. PMID 20164156 DOI: 10.1152/ajprenal.00592.2009  0.88
2010 Calamito M, Juntilla MM, Thomas M, Northrup DL, Rathmell J, Birnbaum MJ, Koretzky G, Allman D. Akt1 and Akt2 promote peripheral B-cell maturation and survival. Blood. 115: 4043-50. PMID 20042722 DOI: 10.1182/blood-2009-09-241638  0.88
2010 Gleason CE, Ning Y, Cominski TP, Gupta R, Kaestner KH, Pintar JE, Birnbaum MJ. Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth. Molecular Endocrinology (Baltimore, Md.). 24: 178-92. PMID 19897600 DOI: 10.1210/me.2009-0167  0.88
2009 Leavens KF, Easton RM, Shulman GI, Previs SF, Birnbaum MJ. Akt2 is required for hepatic lipid accumulation in models of insulin resistance. Cell Metabolism. 10: 405-18. PMID 19883618 DOI: 10.1016/j.cmet.2009.10.004  0.88
2009 DiAngelo JR, Bland ML, Bambina S, Cherry S, Birnbaum MJ. The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling. Proceedings of the National Academy of Sciences of the United States of America. 106: 20853-8. PMID 19861550 DOI: 10.1073/pnas.0906749106  0.88
2009 DiAngelo JR, Birnbaum MJ. Regulation of fat cell mass by insulin in Drosophila melanogaster. Molecular and Cellular Biology. 29: 6341-52. PMID 19822665 DOI: 10.1128/MCB.00675-09  0.88
2009 Gross DN, Wan M, Birnbaum MJ. The role of FOXO in the regulation of metabolism. Current Diabetes Reports. 9: 208-14. PMID 19490822 DOI: 10.1007/s11892-009-0034-5  0.88
2009 Mauro TM, McCormick JA, Wang J, Boini KM, Ray L, Monks B, Birnbaum MJ, Lang F, Pearce D. Akt2 and SGK3 are both determinants of postnatal hair follicle development. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 3193-202. PMID 19433625 DOI: 10.1096/fj.08-123729  0.88
2009 Symons JD, McMillin SL, Riehle C, Tanner J, Palionyte M, Hillas E, Jones D, Cooksey RC, Birnbaum MJ, McClain DA, Zhang QJ, Gale D, Wilson LJ, Abel ED. Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure. Circulation Research. 104: 1085-94. PMID 19342603 DOI: 10.1161/CIRCRESAHA.108.189316  0.88
2009 Yun SJ, Tucker DF, Kim EK, Kim MS, Do KH, Ha JM, Lee SY, Yun J, Kim CD, Birnbaum MJ, Bae SS. Differential regulation of Akt/protein kinase B isoforms during cell cycle progression. Febs Letters. 583: 685-90. PMID 19166849 DOI: 10.1016/j.febslet.2009.01.005  0.88
2009 Steinberg GR, Watt MJ, Ernst M, Birnbaum MJ, Kemp BE, Jørgensen SB. Ciliary neurotrophic factor stimulates muscle glucose uptake by a PI3-kinase-dependent pathway that is impaired with obesity. Diabetes. 58: 829-39. PMID 19136654 DOI: 10.2337/db08-0659  0.88
2009 Southgate RJ, Bruce CR, Carey AL, Steinberg GR, Walder K, Monks R, Watt MJ, Hawley JA, Birnbaum MJ, Febbraio MA. PGC-1α gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle (FASEB Journal (2005) DOI: 10.1096/fj.05-3993fje) Faseb Journal. 23: 2790. DOI: 10.1096/fj.05-3993fjeRET  0.88
2009 Wang Y, Litvinov RI, Chen X, Bach TL, Lian L, Petrich BG, Monkley SJ, Kanaho Y, Critchley DR, Sasaki T, Birnbaum MJ, Weisel JW, Hartwig J, Abrams CS. Loss of PIP5KIγ, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes (Journal of Clinical Investigation (2009) 119, (421) DOI:10.1172/JCI34239C1) Journal of Clinical Investigation. 119: 421.  0.88
2008 Plastaras JP, Dorsey JF, Carroll K, Kim SH, Birnbaum MJ, El-Deiry WS. Role of PI3K/Akt signaling in TRAIL- and radiation-induced gastrointestinal apoptosis. Cancer Biology & Therapy. 7: 2047-53. PMID 19106634  0.88
2008 Alliouachene S, Tuttle RL, Boumard S, Lapointe T, Berissi S, Germain S, Jaubert F, Tosh D, Birnbaum MJ, Pende M. Constitutively active Akt1 expression in mouse pancreas requires S6 kinase 1 for insulinoma formation. The Journal of Clinical Investigation. 118: 3629-38. PMID 18846252 DOI: 10.1172/JCI35237  0.88
2008 Kim EK, Yun SJ, Do KH, Kim MS, Cho M, Suh DS, Kim CD, Kim JH, Birnbaum MJ, Bae SS. Lysophosphatidic acid induces cell migration through the selective activation of Akt1. Experimental & Molecular Medicine. 40: 445-52. PMID 18779657 DOI: 10.3858/emm.2008.40.4.445  0.88
2008 Kim EK, Tucker DF, Yun SJ, Do KH, Kim MS, Kim JH, Kim CD, Birnbaum MJ, Bae SS. Linker region of Akt1/protein kinase Balpha mediates platelet-derived growth factor-induced translocation and cell migration. Cellular Signalling. 20: 2030-7. PMID 18700164 DOI: 10.1016/j.cellsig.2008.07.012  0.88
2008 Yun SJ, Kim EK, Tucker DF, Kim CD, Birnbaum MJ, Bae SS. Isoform-specific regulation of adipocyte differentiation by Akt/protein kinase Balpha. Biochemical and Biophysical Research Communications. 371: 138-43. PMID 18423396 DOI: 10.1016/j.bbrc.2008.04.029  0.88
2008 Gross DN, van den Heuvel AP, Birnbaum MJ. The role of FoxO in the regulation of metabolism. Oncogene. 27: 2320-36. PMID 18391974 DOI: 10.1038/onc.2008.25  0.88
2008 Birnbaum MJ. Signal transduction. Sweet conundrum. Science (New York, N.Y.). 319: 1348-9. PMID 18323441 DOI: 10.1126/science.1155915  0.88
2008 Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, et al. Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences of the United States of America. 105: 3622-7. PMID 18292230 DOI: 10.1073/pnas.0709180105  0.88
2008 Wang Y, Litvinov RI, Chen X, Bach TL, Lian L, Petrich BG, Monkley SJ, Kanaho Y, Critchley DR, Sasaki T, Birnbaum MJ, Weisel JW, Hartwig J, Abrams CS. Loss of PIP5KIgamma, unlike other PIP5KI isoforms, impairs the integrity of the membrane cytoskeleton in murine megakaryocytes. The Journal of Clinical Investigation. 118: 812-9. PMID 18188447 DOI: 10.1172/JCI34239  0.88
2007 Fernández-Hernando C, Ackah E, Yu J, Suárez Y, Murata T, Iwakiri Y, Prendergast J, Miao RQ, Birnbaum MJ, Sessa WC. Loss of Akt1 leads to severe atherosclerosis and occlusive coronary artery disease. Cell Metabolism. 6: 446-57. PMID 18054314 DOI: 10.1016/j.cmet.2007.10.007  0.88
2007 Gao S, Kinzig KP, Aja S, Scott KA, Keung W, Kelly S, Strynadka K, Chohnan S, Smith WW, Tamashiro KL, Ladenheim EE, Ronnett GV, Tu Y, Birnbaum MJ, Lopaschuk GD, et al. Leptin activates hypothalamic acetyl-CoA carboxylase to inhibit food intake. Proceedings of the National Academy of Sciences of the United States of America. 104: 17358-63. PMID 17956983 DOI: 10.1073/pnas.0708385104  0.88
2007 O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, ... Birnbaum MJ, et al. A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy. Cell Metabolism. 6: 294-306. PMID 17908558 DOI: 10.1016/j.cmet.2007.09.001  0.88
2007 Juntilla MM, Wofford JA, Birnbaum MJ, Rathmell JC, Koretzky GA. Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. Proceedings of the National Academy of Sciences of the United States of America. 104: 12105-10. PMID 17609365 DOI: 10.1073/pnas.0705285104  0.88
2007 Li X, Monks B, Ge Q, Birnbaum MJ. Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator. Nature. 447: 1012-6. PMID 17554339 DOI: 10.1038/nature05861  0.88
2007 Gleason CE, Gross DN, Birnbaum MJ. When the usual insulin is just not enough. Proceedings of the National Academy of Sciences of the United States of America. 104: 8681-2. PMID 17517662 DOI: 10.1073/pnas.0702844104  0.88
2007 O'Shaughnessy RF, Welti JC, Cooke JC, Avilion AA, Monks B, Birnbaum MJ, Byrne C. AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation. The Journal of Biological Chemistry. 282: 17297-305. PMID 17439945 DOI: 10.1074/jbc.M610386200  0.88
2007 Holland WL, Brozinick JT, Wang LP, Hawkins ED, Sargent KM, Liu Y, Narra K, Hoehn KL, Knotts TA, Siesky A, Nelson DH, Karathanasis SK, Fontenot GK, Birnbaum MJ, Summers SA. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metabolism. 5: 167-79. PMID 17339025 DOI: 10.1016/j.cmet.2007.01.002  0.88
2007 Gleason CE, Lu D, Witters LA, Newgard CB, Birnbaum MJ. The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells. The Journal of Biological Chemistry. 282: 10341-51. PMID 17287212 DOI: 10.1074/jbc.M610631200  0.88
2007 Bach TL, Kerr WT, Wang Y, Bauman EM, Kine P, Whiteman EL, Morgan RS, Williamson EK, Ostap EM, Burkhardt JK, Koretzky GA, Birnbaum MJ, Abrams CS. PI3K regulates pleckstrin-2 in T-cell cytoskeletal reorganization. Blood. 109: 1147-55. PMID 17008542 DOI: 10.1182/blood-2006-02-001339  0.88
2006 Boxer RB, Stairs DB, Dugan KD, Notarfrancesco KL, Portocarrero CP, Keister BA, Belka GK, Cho H, Rathmell JC, Thompson CB, Birnbaum MJ, Chodosh LA. Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. Cell Metabolism. 4: 475-90. PMID 17141631 DOI: 10.1016/j.cmet.2006.10.011  0.88
2006 Zhou GL, Tucker DF, Bae SS, Bhatheja K, Birnbaum MJ, Field J. Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. The Journal of Biological Chemistry. 281: 36443-53. PMID 17012749 DOI: 10.1074/jbc.M600788200  0.88
2006 Liu X, Shi Y, Birnbaum MJ, Ye K, De Jong R, Oltersdorf T, Giranda VL, Luo Y. Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions. The Journal of Biological Chemistry. 281: 31380-8. PMID 16923802 DOI: 10.1074/jbc.M606603200  0.88
2006 Evans GJ, Barclay JW, Prescott GR, Jo SR, Burgoyne RD, Birnbaum MJ, Morgan A. Protein kinase B/Akt is a novel cysteine string protein kinase that regulates exocytosis release kinetics and quantal size. The Journal of Biological Chemistry. 281: 1564-72. PMID 16243840 DOI: 10.1074/jbc.M503628200  0.88
2005 Birnbaum MJ. Rejoinder: Genetic Research into the Causes of Type 2 Diabetes Mellitus. Anthropology & Medicine. 12: 129-34. PMID 26868460 DOI: 10.1080/13648470500139908  0.88
2005 Southgate RJ, Bruce CR, Carey AL, Steinberg GR, Walder K, Monks R, Watt MJ, Hawley JA, Birnbaum MJ, Febbraio MA. PGC-1alpha gene expression is down-regulated by Akt- mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 19: 2072-4. PMID 16203862 DOI: 10.1096/fj.05-3993fje  0.88
2005 Kim IA, Bae SS, Fernandes A, Wu J, Muschel RJ, McKenna WG, Birnbaum MJ, Bernhard EJ. Selective inhibition of Ras, phosphoinositide 3 kinase, and Akt isoforms increases the radiosensitivity of human carcinoma cell lines. Cancer Research. 65: 7902-10. PMID 16140961 DOI: 10.1158/0008-5472.CAN-05-0513  0.88
2005 Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC. Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. The Journal of Clinical Investigation. 115: 2119-27. PMID 16075056 DOI: 10.1172/JCI24726  0.88
2005 Birnbaum MJ. Activating AMP-activated protein kinase without AMP. Molecular Cell. 19: 289-90. PMID 16061173 DOI: 10.1016/j.molcel.2005.07.012  0.88
2005 Birnbaum MJ. SHIPing news: a new way to keep your weight down. Cell Metabolism. 1: 90-2. PMID 16054050 DOI: 10.1016/j.cmet.2005.01.007  0.88
2005 Jones RG, Plas DR, Kubek S, Buzzai M, Mu J, Xu Y, Birnbaum MJ, Thompson CB. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint. Molecular Cell. 18: 283-93. PMID 15866171 DOI: 10.1016/j.molcel.2005.03.027  0.88
2005 Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T, Ludwig T, Efstratiadis A, Birnbaum MJ. Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Molecular and Cellular Biology. 25: 1869-78. PMID 15713641 DOI: 10.1128/MCB.25.5.1869-1878.2005  0.88
2005 Hammerman PS, Fox CJ, Birnbaum MJ, Thompson CB. Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. Blood. 105: 4477-83. PMID 15705789 DOI: 10.1182/blood-2004-09-3706  0.88
2005 Patel NA, Kaneko S, Apostolatos HS, Bae SS, Watson JE, Davidowitz K, Chappell DS, Birnbaum MJ, Cheng JQ, Cooper DR. Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40. The Journal of Biological Chemistry. 280: 14302-9. PMID 15684423 DOI: 10.1074/jbc.M411485200  0.88
2005 Steppan CM, Wang J, Whiteman EL, Birnbaum MJ, Lazar MA. Activation of SOCS-3 by resistin. Molecular and Cellular Biology. 25: 1569-75. PMID 15684405 DOI: 10.1128/MCB.25.4.1569-1575.2005  0.88
2005 Plas DR, Kubek S, Buzzai M, Birnbaum MJ, Mu J, Xu Y. An AMPK-p53 connection mediates a checkpoint to inhibit cell proliferation in response to low glucose Cancer Biology and Therapy. 4.  0.88
2004 Birnbaum MJ. On the InterAktion between hexokinase and the mitochondrion. Developmental Cell. 7: 781-2. PMID 15572122 DOI: 10.1016/j.devcel.2004.11.016  0.88
2004 Kong M, Fox CJ, Mu J, Solt L, Xu A, Cinalli RM, Birnbaum MJ, Lindsten T, Thompson CB. The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science (New York, N.Y.). 306: 695-8. PMID 15499020 DOI: 10.1126/science.1100537  0.88
2004 Li Y, Soos TJ, Li X, Wu J, Degennaro M, Sun X, Littman DR, Birnbaum MJ, Polakiewicz RD. Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). The Journal of Biological Chemistry. 279: 45304-7. PMID 15364919 DOI: 10.1074/jbc.C400186200  0.88
2004 Russell RR, Li J, Coven DL, Pypaert M, Zechner C, Palmeri M, Giordano FJ, Mu J, Birnbaum MJ, Young LH. AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury. The Journal of Clinical Investigation. 114: 495-503. PMID 15314686 DOI: 10.1172/JCI19297  0.88
2004 Holmes BF, Lang DB, Birnbaum MJ, Mu J, Dohm GL. AMP kinase is not required for the GLUT4 response to exercise and denervation in skeletal muscle. American Journal of Physiology. Endocrinology and Metabolism. 287: E739-43. PMID 15165992 DOI: 10.1152/ajpendo.00080.2004  0.88
2004 Minokoshi Y, Alquier T, Furukawa H, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferré P, Birnbaum MJ, Stuck BJ, Kahn BB. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus Nature. 428: 569-574. PMID 15058305 DOI: 10.1038/nature02440  0.88
2004 Emamian ES, Hall D, Birnbaum MJ, Karayiorgou M, Gogos JA. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nature Genetics. 36: 131-7. PMID 14745448 DOI: 10.1038/ng1296  0.88
2004 Li X, Leu S, Cheong A, Zhang H, Baibakov B, Shih C, Birnbaum MJ, Donowitz M. Akt2, phosphatidylinositol 3-kinase, and PTEN are in lipid rafts of intestinal cells: role in absorption and differentiation. Gastroenterology. 126: 122-35. PMID 14699494 DOI: 10.1053/j.gastro.2003.10.061  0.88
2003 Lawrence JTR, Birnbaum MJ. ADP-ribosylation factor 6 regulates insulin secretion through plasma membrane phosphatidylinositol 4,5-bisphosphate Proceedings of the National Academy of Sciences of the United States of America. 100: 13320-13325. PMID 14585928 DOI: 10.1073/pnas.2232129100  0.88
2003 Bae SS, Cho H, Mu J, Birnbaum MJ. Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B The Journal of Biological Chemistry. 278: 49530-49536. PMID 14522993  0.88
2003 Yin W, Mu J, Birnbaum MJ. Role of AMP-activated Protein Kinase in Cyclic AMP-dependent Lipolysis in 3T3-L1 Adipocytes Journal of Biological Chemistry. 278: 43074-43080. PMID 12941946 DOI: 10.1074/jbc.M308484200  0.88
2003 Whiteman EL, Chen JJ, Birnbaum MJ. Platelet-derived growth factor (PDGF) stimulates glucose transport in 3T3-L1 adipocytes overexpressing PDGF receptor by a pathway independent of insulin receptor substrates Endocrinology. 144: 3811-3820. PMID 12933652 DOI: 10.1210/en.2003-0480  0.88
2003 Birnbaum MJ. Lipolysis: More than just a lipase Journal of Cell Biology. 161: 1011-1012. PMID 12810703 DOI: 10.1083/jcb.200306008  0.88
2003 Burcelin R, Crivelli V, Perrin C, Da Costa A, Mu J, Kahn BB, Birnbaum MJ, Kahn CR, Vollenweider P, Thorens B. GLUT4, AMP kinase, but not the insulin receptor, are required for hepatoportal glucose sensor-stimulated muscle glucose utilization Journal of Clinical Investigation. 111: 1555-1562. PMID 12750405 DOI: 10.1172/JCI200316888  0.88
2003 Whiteman EL, Birnbaum MJ. Assaying tyrosine phosphorylation of insulin receptor and insulin receptor substrates Methods in Molecular Medicine. 83: 119-126. PMID 12619723  0.88
2003 Mu J, Barton ER, Birnbaum MJ. Selective suppression of AMP-activated protein kinase in skeletal muscle: Update on 'lazy mice' Biochemical Society Transactions. 31: 236-241. PMID 12546693  0.88
2003 Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA. Identification of a proline-rich Akt substrate as a 14-3-3 binding partner Journal of Biological Chemistry. 278: 10189-10194. PMID 12524439 DOI: 10.1074/jbc.M210837200  0.88
2003 Viollet B, Andreelli F, Jørgensen SB, Perrin C, Geloen A, Flamez D, Mu J, Lenzner C, Baud O, Bennoun M, Gomas E, Nicolas G, Wojtaszewski JF, Kahn A, Carling D, ... ... Birnbaum MJ, et al. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. The Journal of Clinical Investigation. 111: 91-8. PMID 12511592 DOI: 10.1172/JCI16567  0.88
2002 Zong H, Ren JM, Young LH, Pypaert M, Mu J, Birnbaum MJ, Shulman GI. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proceedings of the National Academy of Sciences of the United States of America. 99: 15983-7. PMID 12444247 DOI: 10.1073/pnas.252625599  0.88
2002 Whiteman EL, Cho H, Birnbaum MJ. Role of Akt/protein kinase B in metabolism Trends in Endocrinology and Metabolism. 13: 444-451. PMID 12431841 DOI: 10.1016/S1043-2760(02)00662-8  0.88
2002 Stolovich M, Tang H, Hornstein E, Levy G, Cohen R, Bae SS, Birnbaum MJ, Meyuhas O. Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation. Molecular and Cellular Biology. 22: 8101-13. PMID 12417714 DOI: 10.1128/MCB.22.23.8101-8113.2002  0.88
2002 Kim AH, Yano H, Cho H, Meyer D, Monks B, Margolis B, Birnbaum MJ, Chao MV. Akt1 regulates a JNK scaffold during excitotoxic apoptosis. Neuron. 35: 697-709. PMID 12194869 DOI: 10.1016/S0896-6273(02)00821-8  0.88
2002 Birnbaum MJ. RhoGAP: The next big thing for small mice? Developmental Cell. 2: 521-523. PMID 12015960 DOI: 10.1016/S1534-5807(02)00183-1  0.88
2002 Joost HG, Bell GI, Best JD, Birnbaum MJ, Charron MJ, Chen YT, Doege H, James DE, Lodish HF, Moley KH, Moley JF, Mueckler M, Rogers S, Schürmann A, Seino S, et al. Nomenclature of the GLUT/SLC2A family of sugar/polyol transport facilitators. American Journal of Physiology. Endocrinology and Metabolism. 282: E974-6. PMID 11882521 DOI: 10.1152/ajpendo.00407.2001  0.88
2001 Nadler ST, Stoehr JP, Rabaglia ME, Schueler KL, Birnbaum MJ, Attie AD. Normal Akt/PKB with reduced PI3K activation in insulin-resistant mice American Journal of Physiology - Endocrinology and Metabolism. 281: E1249-E1254. PMID 11701440  0.88
2001 Tuttle RL, Gill NS, Pugh W, Lee JP, Koeberlein B, Furth EE, Polonsky KS, Naji A, Birnbaum MJ. Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha. Nature Medicine. 7: 1133-7. PMID 11590437 DOI: 10.1038/nm1001-1133  0.88
2001 Choi SL, Kim SJ, Lee KT, Kim J, Mu J, Birnbaum MJ, Soo Kim S, Ha J. The regulation of AMP-activated protein kinase by H2O2 Biochemical and Biophysical Research Communications. 287: 92-97. PMID 11549258 DOI: 10.1006/bbrc.2001.5544  0.88
2001 Birnbaum MJ. Turning down insulin signaling Journal of Clinical Investigation. 108: 655-659. PMID 11544268 DOI: 10.1172/JCI200113714  0.88
2001 Cho H, Thorvaldsen JL, Chu Q, Feng F, Birnbaum MJ. Akt1/PKBα Is Required for Normal Growth but Dispensable for Maintenance of Glucose Homeostasis in Mice Journal of Biological Chemistry. 276: 38349-38352. PMID 11533044 DOI: 10.1074/jbc.C100462200  0.88
2001 Todd J, Lawrence R, Birnbaum MJ. ADP-ribosylation factor 6 delineates separate pathways used by endothelin 1 and insulin for stimulating glucose uptake in 3T3-L1 adipocytes Molecular and Cellular Biology. 21: 5276-5285. PMID 11438681 DOI: 10.1128/MCB.21.15.5276-5285.2001  0.88
2001 Mu J, Brozinick JT, Valladares O, Bucan M, Birnbaum MJ. A role for AMP-activated protein kinase in contraction- and hypoxia-regulated glucose transport in skeletal muscle Molecular Cell. 7: 1085-1094. PMID 11389854 DOI: 10.1016/S1097-2765(01)00251-9  0.88
2001 Miron M, Verdú J, Lachance PE, Birnbaum MJ, Lasko PF, Sonenberg N. The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nature Cell Biology. 3: 596-601. PMID 11389445 DOI: 10.1038/35078571  0.88
2001 Cho H, Mu J, Kim JK, Thorvaldsen JL, Chu Q, Crenshaw EB, Kaestner KH, Bartolomei MS, Shulman GI, Birnbaum MJ. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ) Science. 292: 1728-1731. PMID 11387480 DOI: 10.1126/science.292.5522.1728  0.88
2001 Birnbaum MJ. Diabetes. Dialogue between muscle and fat Nature. 409: 672-673. PMID 11217842  0.88
2000 Summers SA, Whiteman EL, Birnbaum MJ. Insulin signaling in the adipocyte International Journal of Obesity. 24: S67-S70. PMID 11126246 DOI: 10.1038/sj/ijo/0801509  0.88
2000 Li M, Wang X, Meintzer MK, Laessig T, Birnbaum MJ, Heidenreich KA. Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3β Molecular and Cellular Biology. 20: 9356-9363. PMID 11094086 DOI: 10.1128/MCB.20.24.9356-9363.2000  0.88
2000 Okano JI, Gaslightwala I, Birnbaum MJ, Rustgi AK, Nakagawa H. Akt/protein kinase B isoforms are differentially regulated by epidermal growth factor stimulation Journal of Biological Chemistry. 275: 30934-30942. PMID 10908564  0.88
2000 Fujii N, Hayashi T, Hirshman MF, Smith JT, Habinowski SA, Kaijser L, Mu J, Ljungqvist O, Birnbaum MJ, Witters LA, Thorell A, Goodyear LJ. Exercise induces isoform-specific increase in 5' AMP-activated protein kinase activity in human skeletal muscle Biochemical and Biophysical Research Communications. 273: 1150-1155. PMID 10891387 DOI: 10.1006/bbrc.2000.3073  0.88
2000 Garza LA, Birnbaum MJ. Insulin-responsive aminopeptidase trafficking in 3T3-L1 adipocytes Journal of Biological Chemistry. 275: 2560-2567. PMID 10644714 DOI: 10.1074/jbc.275.4.2560  0.88
1999 Summers SA, Yin VP, Whiteman EL, Garza LA, Cho H, Tuttle RL, Birnbaum MJ. Signaling pathways mediating insulin-stimulated glucose transport. Annals of the New York Academy of Sciences. 892: 169-86. PMID 10842662  0.88
1999 Verdu J, Buratovich MA, Wilder EL, Birnbaum MJ. Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nature Cell Biology. 1: 500-6. PMID 10587646 DOI: 10.1038/70293  0.88
1999 Hill MM, Clark SF, Tucker DF, Birnbaum MJ, James DE, Macaulay SL. A role for protein kinase Bβ/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes Molecular and Cellular Biology. 19: 7771-7781. PMID 10523666  0.88
1999 Hausdorff SF, Fingar DC, Morioka K, Garza LA, Whiteman EL, Summers SA, Birnbaum MJ. Identification of wortmannin-sensitive targets in 3T3-L1 adipocytes. DissociationoOf insulin-stimulated glucose uptake and glut4 translocation. The Journal of Biological Chemistry. 274: 24677-84. PMID 10455135 DOI: 10.1074/jbc.274.35.24677  0.88
1999 Cass LA, Summers SA, Prendergast GV, Backer JM, Birnbaum MJ, Meinkoth JL. Protein kinase A-dependent and -independent signaling pathways contribute to cyclic AMP-stimulated proliferation Molecular and Cellular Biology. 19: 5882-5891. PMID 10454535  0.88
1999 Summers SA, Whiteman EL, Cho H, Lipfert L, Birnbaum MJ. Differentiation-dependent suppression of platelet-derived growth factor signaling in cultured adipocytes Journal of Biological Chemistry. 274: 23858-23867. PMID 10446150 DOI: 10.1074/jbc.274.34.23858  0.88
1999 Summers SA, Kao AW, Kohn AD, Backus GS, Roth RA, Pessin JE, Birnbaum MJ. The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism. The Journal of Biological Chemistry. 274: 17934-40. PMID 10364240 DOI: 10.1074/jbc.274.25.17934  0.88
1999 Li HL, Davis WW, Whiteman EL, Birnbaum MJ, Puré E. The tyrosine kinases Syk and Lyn exert opposing effects on the activation of protein kinase Akt/PKB in B lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 96: 6890-5. PMID 10359809 DOI: 10.1073/pnas.96.12.6890  0.88
1998 Summers SA, Garza LA, Zhou H, Birnbaum MJ. Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide Molecular and Cellular Biology. 18: 5457-5464. PMID 9710629  0.88
1998 Zhou H, Summers SA, Birnbaum MJ, Pittman RN. Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis. The Journal of Biological Chemistry. 273: 16568-75. PMID 9632728 DOI: 10.1074/jbc.273.26.16568  0.88
1998 Brozinick JT, Birnbaum MJ. Insulin, but not contraction, activates Akt/PKB in isolated rat skeletal muscle Journal of Biological Chemistry. 273: 14679-14682. PMID 9614064 DOI: 10.1074/jbc.273.24.14679  0.88
1998 Summers SA, Lipfert L, Birnbaum MJ. Polyoma middle T antigen activates the Ser/Thr kinase Akt in a PI3-kinase-dependent manner Biochemical and Biophysical Research Communications. 246: 76-81. PMID 9600071 DOI: 10.1006/bbrc.1998.8575  0.88
1998 Kohn AD, Barthel A, Kovacina KS, Boge A, Wallach B, Summers SA, Birnbaum MJ, Scott PH, Lawrence JC, Roth RA. Construction and characterization of a conditionally active version of the serine/threonine kinase Akt. The Journal of Biological Chemistry. 273: 11937-43. PMID 9565622 DOI: 10.1074/jbc.273.19.11937  0.88
1998 Calera MR, Martinez C, Liu H, Jack AK, Birnbaum MJ, Pilch PF. Insulin increases the association of Akt-2 with Glut4-containing vesicles. The Journal of Biological Chemistry. 273: 7201-4. PMID 9516411 DOI: 10.1074/jbc.273.13.7201  0.88
1998 Seidner G, Alvarez MG, Yeh JI, O'Driscoll KR, Klepper J, Stump TS, Wang D, Spinner NB, Birnbaum MJ, De Vivo DC. GLUT-1 deficiency syndrome caused by haploinsufficiency of the blood- brain barrier hexose carrier Nature Genetics. 18: 188-191. PMID 9462754 DOI: 10.1038/ng0298-188  0.88
1997 Summers SA, Birnbaum MJ. A role for the serine/threonine kinase, Akt, in insulin-stimulated glucose uptake Biochemical Society Transactions. 25: 981-988. PMID 9388586  0.88
1997 Guillam MT, Hümmler E, Schaerer E, Wu JY, Birnbaum MJ, Beermann F, Schmidt A, Dériaz N, Thorens B. Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2 Nature Genetics. 17: 327-330. PMID 9354799 DOI: 10.1038/ng1197-327  0.88
1997 Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science (New York, N.Y.). 275: 661-5. PMID 9005851 DOI: 10.1126/science.275.5300.661  0.88
1996 Kohn AD, Summers SA, Birnbaum MJ, Roth RA. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. The Journal of Biological Chemistry. 271: 31372-8. PMID 8940145 DOI: 10.1074/jbc.271.49.31372  0.88
1996 Hausdorff SF, Fingar DC, Birnbaum MJ. Signalling pathways mediating insulin-activated glucose transport Seminars in Cell and Developmental Biology. 7: 239-247. DOI: 10.1006/scdb.1996.0032  0.88
1995 Young AT, Dahl J, Hausdorff SF, Bauer PH, Birnbaum MJ, Benjamin TL. Phosphatidylinositol 3-kinase binding to polyoma virus middle tumor antigen mediates elevation of glucose transport by increasing translocation of the GLUT1 transporter. Proceedings of the National Academy of Sciences of the United States of America. 92: 11613-7. PMID 8524814 DOI: 10.1073/pnas.92.25.11613  0.88
1995 Yeh JI, Gulve EA, Rameh L, Birnbaum MJ. The effects of wortmannin on rat skeletal muscle. Dissociation of signaling pathways for insulin- and contraction-activated hexose transport Journal of Biological Chemistry. 270: 2107-2111. PMID 7836438 DOI: 10.1074/jbc.270.5.2107  0.88
1995 Hausdorff SF, Bennett AM, Neel BG, Birnbaum MJ. Different signaling roles of SHPTP2 in insulin-induced GLUT1 expression and GLUT4 translocation Journal of Biological Chemistry. 270: 12965-12968. PMID 7768884 DOI: 10.1074/jbc.270.22.12965  0.88
1995 Verhey KJ, Yeh JI, Birnbaum MJ. Distinct signals in the GLUT4 glucose transporter for internalization and for targeting to an insulin-responsive compartment Journal of Cell Biology. 130: 1071-1079. PMID 7657693 DOI: 10.1083/jcb.130.5.1071  0.88
1995 Hudson AW, Birnbaum MJ. Identification of a nonneuronal isoform of synaptotagmin Proceedings of the National Academy of Sciences of the United States of America. 92: 5895-5899. PMID 7597049 DOI: 10.1073/pnas.92.13.5895  0.88
1995 Yen JI, Verhey KJ, Birnbaum MJ. Kinetic analysis of glucose transporter trafficking in fibroblasts and adipocytes Biochemistry. 34: 15523-15531. PMID 7492554  0.88
1995 Verhey KJ, Yeh JI, Birnbaum MJ. GLUT-4 targeting: lessons from insulin-responsive cells Trends in Cell Biology. 5: 451.  0.88
1994 Hausdorff SF, Frangioni JV, Birnbaum MJ. Role of p21ras in insulin-stimulated glucose transport in 3T3-L1 adipocytes Journal of Biological Chemistry. 269: 21391-21394. PMID 8063767  0.88
1994 Chuang LM, Hausdorff SF, Myers MG, White MF, Birnbaum MJ, Kahn CR. Interactive roles of ras, insulin receptor substrate-1, and proteins with Src homology-2 domains in insulin signaling in Xenopus oocytes Journal of Biological Chemistry. 269: 27645-27649. PMID 7961682  0.88
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