| Year |
Citation |
Score |
| 2021 |
Ramirez Reyes JMJ, Cuesta R, Pause A. Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways. Frontiers in Cell and Developmental Biology. 9: 667311. PMID 33981707 DOI: 10.3389/fcell.2021.667311 |
0.324 |
|
| 2021 |
Paquette M, El-Houjeiri L, C Zirden L, Puustinen P, Blanchette P, Jeong H, Dejgaard K, Siegel PM, Pause A. AMPK-dependent phosphorylation is required for transcriptional activation of TFEB and TFE3. Autophagy. 1-19. PMID 33734022 DOI: 10.1080/15548627.2021.1898748 |
0.323 |
|
| 2019 |
Lahaie S, Morales D, Bagci H, Hamoud N, Castonguay CE, Kazan JM, Desrochers G, Klar A, Gingras AC, Pause A, Côté JF, Kania A. The endosomal sorting adaptor HD-PTP is required for ephrin-B:EphB signalling in cellular collapse and spinal motor axon guidance. Scientific Reports. 9: 11945. PMID 31420572 DOI: 10.1038/S41598-019-48421-9 |
0.317 |
|
| 2019 |
El-Houjeiri L, Possik E, Vijayaraghavan T, Paquette M, Martina JA, Kazan JM, Ma EH, Jones R, Blanchette P, Puertollano R, Pause A. The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen Resistance. Cell Reports. 26: 3613-3628.e6. PMID 30917316 DOI: 10.1016/J.Celrep.2019.02.102 |
0.334 |
|
| 2018 |
Desrochers G, Kazan JM, Pause A. Structure and functions of HD-PTP in receptor trafficking and cancer. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. PMID 29879361 DOI: 10.1139/Bcb-2017-0322 |
0.375 |
|
| 2018 |
Cramer Z, Sadek J, Vazquez GG, Di Marco S, Pause A, Pelletier J, Gallouzi IE. eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways. Scientific Reports. 8: 8414. PMID 29849089 DOI: 10.1038/S41598-018-26625-9 |
0.337 |
|
| 2018 |
Lundquist MR, Goncalves MD, Loughran RM, Possik E, Vijayaraghavan T, Yang A, Pauli C, Ravi A, Verma A, Yang Z, Johnson JL, Wong JCY, Ma Y, Hwang KS, Weinkove D, ... ... Pause A, et al. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy. Molecular Cell. 70: 531-544.e9. PMID 29727621 DOI: 10.1016/J.Molcel.2018.03.037 |
0.316 |
|
| 2018 |
Omer A, Patel D, Lian XJ, Sadek J, Di Marco S, Pause A, Gorospe M, Gallouzi IE. Stress granules counteract senescence by sequestration of PAI-1. Embo Reports. PMID 29592859 DOI: 10.15252/Embr.201744722 |
0.316 |
|
| 2018 |
Paquette M, El-Houjeiri L, Pause A. mTOR Pathways in Cancer and Autophagy. Cancers. 10. PMID 29329237 DOI: 10.3390/Cancers10010018 |
0.337 |
|
| 2017 |
Gingras MC, Kazan JM, Pause A. Role of ESCRT component HD-PTP/PTPN23 in cancer. Biochemical Society Transactions. 45: 845-854. PMID 28620046 DOI: 10.1042/Bst20160332 |
0.325 |
|
| 2016 |
Manteghi S, Gingras MC, Kharitidi D, Galarneau L, Marques M, Yan M, Cencic R, Robert F, Paquet M, Witcher M, Pelletier J, Pause A. Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer. Cell Reports. PMID 27210750 DOI: 10.1016/J.Celrep.2016.04.076 |
0.406 |
|
| 2016 |
Yan M, Audet-Walsh É, Manteghi S, Rosa Dufour C, Walker B, Baba M, St-Pierre J, Giguère V, Pause A. Chronic AMPK activation via loss of FLCN induces functional beige adipose tissue through PGC-1α/ERRα. Genes & Development. 30: 1034-46. PMID 27151976 DOI: 10.1101/Gad.281410.116 |
0.334 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Pause A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.322 |
|
| 2015 |
Vincent EE, Sergushichev A, Griss T, Gingras MC, Samborska B, Ntimbane T, Coelho PP, Blagih J, Raissi TC, Choinière L, Bridon G, Loginicheva E, Flynn BR, Thomas EC, Tavaré JM, ... ... Pause A, et al. Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth. Molecular Cell. 60: 195-207. PMID 26474064 DOI: 10.1016/J.Molcel.2015.08.013 |
0.358 |
|
| 2015 |
Kharitidi D, Apaja PM, Manteghi S, Suzuki K, Malitskaya E, Roldan A, Gingras MC, Takagi J, Lukacs GL, Pause A. Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration. Cell Reports. 13: 599-609. PMID 26456826 DOI: 10.1016/J.Celrep.2015.09.024 |
0.364 |
|
| 2015 |
Possik E, Ajisebutu A, Manteghi S, Gingras MC, Vijayaraghavan T, Flamand M, Coull B, Schmeisser K, Duchaine T, van Steensel M, Hall DH, Pause A. FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores. Plos Genetics. 11: e1005520. PMID 26439621 DOI: 10.1371/Journal.Pgen.1005520 |
0.343 |
|
| 2014 |
Gingras MC, Pause A. FLCN: A new regulator of AMPK-dependent Warburg metabolic reprogramming. Molecular & Cellular Oncology. 1: e961819. PMID 27308336 DOI: 10.4161/23723548.2014.961819 |
0.333 |
|
| 2014 |
Fonseca BD, Smith EM, Yelle N, Alain T, Bushell M, Pause A. The ever-evolving role of mTOR in translation. Seminars in Cell & Developmental Biology. 36: 102-12. PMID 25263010 DOI: 10.1016/J.Semcdb.2014.09.014 |
0.401 |
|
| 2014 |
Possik E, Jalali Z, Nouët Y, Yan M, Gingras MC, Schmeisser K, Panaite L, Dupuy F, Kharitidi D, Chotard L, Jones RG, Hall DH, Pause A. Folliculin regulates ampk-dependent autophagy and metabolic stress survival. Plos Genetics. 10: e1004273. PMID 24763318 DOI: 10.1371/Journal.Pgen.1004273 |
0.421 |
|
| 2014 |
Yan M, Gingras MC, Dunlop EA, Nouët Y, Dupuy F, Jalali Z, Possik E, Coull BJ, Kharitidi D, Dydensborg AB, Faubert B, Kamps M, Sabourin S, Preston RS, Davies DM, ... ... Pause A, et al. The tumor suppressor folliculin regulates AMPK-dependent metabolic transformation. The Journal of Clinical Investigation. 124: 2640-50. PMID 24762438 DOI: 10.1172/Jci71749 |
0.395 |
|
| 2014 |
Kharitidi D, Manteghi S, Pause A. Pseudophosphatases: methods of analysis and physiological functions. Methods (San Diego, Calif.). 65: 207-18. PMID 24064037 DOI: 10.1016/J.Ymeth.2013.09.009 |
0.382 |
|
| 2013 |
Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, et al. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metabolism. 18: 698-711. PMID 24206664 DOI: 10.1016/J.Cmet.2013.10.001 |
0.358 |
|
| 2013 |
Tee AR, Pause A. Birt-Hogg-Dubé: tumour suppressor function and signalling dynamics central to folliculin. Familial Cancer. 12: 367-72. PMID 23096221 DOI: 10.1007/S10689-012-9576-9 |
0.39 |
|
| 2012 |
Uniacke J, Holterman CE, Lachance G, Franovic A, Jacob MD, Fabian MR, Payette J, Holcik M, Pause A, Lee S. An oxygen-regulated switch in the protein synthesis machinery. Nature. 486: 126-9. PMID 22678294 DOI: 10.1038/Nature11055 |
0.543 |
|
| 2011 |
Tedbury P, Welbourn S, Pause A, King B, Griffin S, Harris M. The subcellular localization of the hepatitis C virus non-structural protein NS2 is regulated by an ion channel-independent function of the p7 protein. The Journal of General Virology. 92: 819-30. PMID 21177929 DOI: 10.1099/Vir.0.027441-0 |
0.34 |
|
| 2011 |
Preston RS, Philp A, Claessens T, Gijezen L, Dydensborg AB, Dunlop EA, Harper KT, Brinkhuizen T, Menko FH, Davies DM, Land SC, Pause A, Baar K, van Steensel MA, Tee AR. Absence of the Birt-Hogg-Dubé gene product is associated with increased hypoxia-inducible factor transcriptional activity and a loss of metabolic flexibility. Oncogene. 30: 1159-73. PMID 21057536 DOI: 10.1038/Onc.2010.497 |
0.408 |
|
| 2010 |
Hudon V, Sabourin S, Dydensborg AB, Kottis V, Ghazi A, Paquet M, Crosby K, Pomerleau V, Uetani N, Pause A. Renal tumour suppressor function of the Birt-Hogg-Dubé syndrome gene product folliculin. Journal of Medical Genetics. 47: 182-9. PMID 19843504 DOI: 10.1136/Jmg.2009.072009 |
0.359 |
|
| 2009 |
Gingras MC, Kharitidi D, Chénard V, Uetani N, Bouchard M, Tremblay ML, Pause A. Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP). The International Journal of Developmental Biology. 53: 1069-74. PMID 19378249 DOI: 10.1387/Ijdb.082820Mg |
0.334 |
|
| 2009 |
Gingras MC, Zhang YL, Kharitidi D, Barr AJ, Knapp S, Tremblay ML, Pause A. HD-PTP is a catalytically inactive tyrosine phosphatase due to a conserved divergence in its phosphatase domain. Plos One. 4: e5105. PMID 19340315 DOI: 10.1371/Journal.Pone.0005105 |
0.385 |
|
| 2009 |
Welbourn S, Jirasko V, Breton V, Reiss S, Penin F, Bartenschlager R, Pause A. Investigation of a role for lysine residues in non-structural proteins 2 and 2/3 of the hepatitis C virus for their degradation and virus assembly. The Journal of General Virology. 90: 1071-80. PMID 19264595 DOI: 10.1099/Vir.0.009944-0 |
0.395 |
|
| 2008 |
Khacho M, Mekhail K, Pilon-Larose K, Pause A, Côté J, Lee S. eEF1A is a novel component of the mammalian nuclear protein export machinery. Molecular Biology of the Cell. 19: 5296-308. PMID 18799616 DOI: 10.1091/Mbc.E08-06-0562 |
0.561 |
|
| 2008 |
Kurban G, Duplan E, Ramlal N, Hudon V, Sado Y, Ninomiya Y, Pause A. Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2. Oncogene. 27: 1004-12. PMID 17700531 DOI: 10.1038/Sj.Onc.1210709 |
0.347 |
|
| 2007 |
Dormoy-Raclet V, Ménard I, Clair E, Kurban G, Mazroui R, Di Marco S, von Roretz C, Pause A, Gallouzi IE. The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner. Molecular and Cellular Biology. 27: 5365-80. PMID 17548472 DOI: 10.1128/Mcb.00113-07 |
0.357 |
|
| 2006 |
Sonenberg N, Pause A. Signal transduction. Protein synthesis and oncogenesis meet again. Science (New York, N.Y.). 314: 428-9. PMID 17053135 DOI: 10.1126/Science.1134031 |
0.425 |
|
| 2006 |
Franovic A, Robert I, Smith K, Kurban G, Pause A, Gunaratnam L, Lee S. Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17. Cancer Research. 66: 8083-90. PMID 16912185 DOI: 10.1158/0008-5472.Can-06-1595 |
0.536 |
|
| 2006 |
Kurban G, Hudon V, Duplan E, Ohh M, Pause A. Characterization of a von Hippel Lindau pathway involved in extracellular matrix remodeling, cell invasion, and angiogenesis. Cancer Research. 66: 1313-9. PMID 16452184 DOI: 10.1158/0008-5472.Can-05-2560 |
0.364 |
|
| 2005 |
Welbourn S, Green R, Gamache I, Dandache S, Lohmann V, Bartenschlager R, Meerovitch K, Pause A. Hepatitis C virus NS2/3 processing is required for NS3 stability and viral RNA replication. The Journal of Biological Chemistry. 280: 29604-11. PMID 15980068 DOI: 10.1074/Jbc.M505019200 |
0.341 |
|
| 2005 |
Svitkin YV, Pause A, Lopez-Lastra M, Perreault S, Sonenberg N. Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3. Journal of Virology. 79: 6868-81. PMID 15890926 DOI: 10.1128/Jvi.79.11.6868-6881.2005 |
0.346 |
|
| 2002 |
Brower CS, Sato S, Tomomori-Sato C, Kamura T, Pause A, Stearman R, Klausner RD, Malik S, Lane WS, Sorokina I, Roeder RG, Conaway JW, Conaway RC. Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. Proceedings of the National Academy of Sciences of the United States of America. 99: 10353-8. PMID 12149480 DOI: 10.1073/Pnas.162424199 |
0.573 |
|
| 2001 |
Svitkin YV, Pause A, Haghighat A, Pyronnet S, Witherell G, Belsham GJ, Sonenberg N. The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. Rna (New York, N.Y.). 7: 382-94. PMID 11333019 DOI: 10.1017/S135583820100108X |
0.351 |
|
| 2001 |
de Paulsen N, Brychzy A, Fournier MC, Klausner RD, Gnarra JR, Pause A, Lee S. Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 98: 1387-92. PMID 11171960 DOI: 10.1073/Pnas.031587498 |
0.582 |
|
| 2000 |
Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. The Embo Journal. 19: 3142-56. PMID 10856257 DOI: 10.1093/Emboj/19.12.3142 |
0.379 |
|
| 1999 |
Iwai K, Yamanaka K, Kamura T, Minato N, Conaway RC, Conaway JW, Klausner RD, Pause A. Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. Proceedings of the National Academy of Sciences of the United States of America. 96: 12436-41. PMID 10535940 DOI: 10.1073/Pnas.96.22.12436 |
0.611 |
|
| 1999 |
Pause A, Peterson B, Schaffar G, Stearman R, Klausner RD. Studying interactions of four proteins in the yeast two-hybrid system: structural resemblance of the pVHL/elongin BC/hCUL-2 complex with the ubiquitin ligase complex SKP1/cullin/F-box protein. Proceedings of the National Academy of Sciences of the United States of America. 96: 9533-8. PMID 10449727 DOI: 10.1073/Pnas.96.17.9533 |
0.566 |
|
| 1999 |
Liakopoulos D, Büsgen T, Brychzy A, Jentsch S, Pause A. Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function. Proceedings of the National Academy of Sciences of the United States of America. 96: 5510-5. PMID 10318914 DOI: 10.1073/Pnas.96.10.5510 |
0.443 |
|
| 1999 |
Lee S, Neumann M, Stearman R, Stauber R, Pause A, Pavlakis GN, Klausner RD. Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Molecular and Cellular Biology. 19: 1486-97. PMID 9891082 DOI: 10.1128/Mcb.19.2.1486 |
0.621 |
|
| 1998 |
Pause A, Lee S, Lonergan KM, Klausner RD. The von Hippel-Lindau tumor suppressor gene is required for cell cycle exit upon serum withdrawal. Proceedings of the National Academy of Sciences of the United States of America. 95: 993-8. PMID 9448273 DOI: 10.1073/Pnas.95.3.993 |
0.576 |
|
| 1997 |
Pause A, Lee S, Worrell RA, Chen DY, Burgess WH, Linehan WM, Klausner RD. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proceedings of the National Academy of Sciences of the United States of America. 94: 2156-61. PMID 9122164 DOI: 10.1073/Pnas.94.6.2156 |
0.627 |
|
| 1996 |
Rousseau D, Gingras AC, Pause A, Sonenberg N. The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth. Oncogene. 13: 2415-20. PMID 8957083 |
0.305 |
|
| 1996 |
Pause A, Aso T, Linehan WM, Conaway JW, Conaway RC, Klausner RD. Interaction of von Hippel-Lindau tumor suppressor gene product with elongin. Methods in Enzymology. 274: 436-41. PMID 8902823 DOI: 10.1016/S0076-6879(96)74035-1 |
0.627 |
|
| 1996 |
Gingras AC, Svitkin Y, Belsham GJ, Pause A, Sonenberg N. Activation of the translational suppressor 4E-BP1 following infection with encephalomyocarditis virus and poliovirus. Proceedings of the National Academy of Sciences of the United States of America. 93: 5578-83. PMID 8643618 DOI: 10.1073/Pnas.93.11.5578 |
0.364 |
|
| 1996 |
Gnarra JR, Duan DR, Weng Y, Humphrey JS, Chen DY, Lee S, Pause A, Dudley CF, Latif F, Kuzmin I, Schmidt L, Duh FM, Stackhouse T, Chen F, Kishida T, et al. Molecular cloning of the von Hippel-Lindau tumor suppressor gene and its role in renal carcinoma. Biochimica Et Biophysica Acta. 1242: 201-10. PMID 8603073 DOI: 10.1016/0304-419X(95)00012-5 |
0.535 |
|
| 1996 |
ROUSSEAU D, GINGRAS A, PAUSE A, SONENBERG N. IDENTIFICATION OF POTENTIAL ANTI-ONCOGENIC PROPERTIES OF elF-4E BINDING PROTEINS 1 AND 2 Biology of the Cell. 88: 69-69. DOI: 10.1016/S0248-4900(97)86843-8 |
0.315 |
|
| 1995 |
Haghighat A, Mader S, Pause A, Sonenberg N. Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E. The Embo Journal. 14: 5701-9. PMID 8521827 DOI: 10.1002/J.1460-2075.1995.Tb00257.X |
0.36 |
|
| 1995 |
Duan DR, Pause A, Burgess WH, Aso T, Chen DY, Garrett KP, Conaway RC, Conaway JW, Linehan WM, Klausner RD. Inhibition of transcription elongation by the VHL tumor suppressor protein. Science (New York, N.Y.). 269: 1402-6. PMID 7660122 DOI: 10.1126/Science.7660122 |
0.635 |
|
| 1995 |
Mader S, Lee H, Pause A, Sonenberg N. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins. Molecular and Cellular Biology. 15: 4990-7. PMID 7651417 DOI: 10.1128/Mcb.15.9.4990 |
0.361 |
|
| 1994 |
Méthot N, Pause A, Hershey JW, Sonenberg N. The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence. Molecular and Cellular Biology. 14: 2307-16. PMID 8139536 DOI: 10.1128/Mcb.14.4.2307 |
0.323 |
|
| 1994 |
Pause A, Méthot N, Svitkin Y, Merrick WC, Sonenberg N. Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation. The Embo Journal. 13: 1205-15. PMID 8131750 DOI: 10.1002/J.1460-2075.1994.Tb06370.X |
0.326 |
|
| 1994 |
Lin TA, Kong X, Haystead TA, Pause A, Belsham G, Sonenberg N, Lawrence JC. PHAS-I as a link between mitogen-activated protein kinase and translation initiation. Science (New York, N.Y.). 266: 653-6. PMID 7939721 DOI: 10.1126/Science.7939721 |
0.343 |
|
| 1994 |
Pause A, Belsham GJ, Gingras AC, Donzé O, Lin TA, Lawrence JC, Sonenberg N. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function. Nature. 371: 762-7. PMID 7935836 DOI: 10.1038/371762A0 |
0.398 |
|
| 1994 |
Svitkin YV, Pause A, Sonenberg N. La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA. Journal of Virology. 68: 7001-7. PMID 7933082 DOI: 10.1128/Jvi.68.11.7001-7007.1994 |
0.364 |
|
| 1993 |
Pause A, Méthot N, Sonenberg N. The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis. Molecular and Cellular Biology. 13: 6789-98. PMID 8413273 DOI: 10.1128/Mcb.13.11.6789 |
0.33 |
|
| 1993 |
Pause A, Sonenberg N. Helicases and RNA unwinding in translation. Current opinion in structural biology 1993, 3: 953-959 Current Opinion in Structural Biology. 3: 953-959. DOI: 10.1016/0959-440X(93)90161-D |
0.302 |
|
| 1992 |
Pause A, Sonenberg N. Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. The Embo Journal. 11: 2643-54. PMID 1378397 DOI: 10.1002/J.1460-2075.1992.Tb05330.X |
0.351 |
|
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