| Year |
Citation |
Score |
| 2023 |
Noguchi S, Tallman KA, Porter NA, Stec DF, Calcutt MW, Boeglin WE, Brash AR. Evaluation of ω-alkynyl-labeled linoleic and arachidonic acids as substrates for recombinant lipoxygenase pathway enzymes. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 1868: 159360. PMID 37336389 DOI: 10.1016/j.bbalip.2023.159360 |
0.393 |
|
| 2023 |
Meyer JM, Boeglin WE, Brash AR. Recombinant PNPLA1 catalyzes the synthesis of acylceramides and acyl acids with selective incorporation of linoleic acid. Journal of Lipid Research. 100379. PMID 37087101 DOI: 10.1016/j.jlr.2023.100379 |
0.391 |
|
| 2023 |
Brash AR, Noguchi S, Boeglin WE, Calcutt MW, Stec DF, Schneider C, Meyer JM. Two C18 hydroxy-cyclohexenone fatty acids from mammalian epidermis: Potential relation to 12R-lipoxygenase and covalent binding of ceramides. The Journal of Biological Chemistry. 104739. PMID 37086788 DOI: 10.1016/j.jbc.2023.104739 |
0.309 |
|
| 2021 |
Weiny JA, Boeglin WE, Calcutt MW, Stec DF, Brash AR. Monolayer autoxidation of arachidonic acid to epoxyeicosatrienoic acids as a model of their potential formation in cell membranes. Journal of Lipid Research. 63: 100159. PMID 34863863 DOI: 10.1016/j.jlr.2021.100159 |
0.345 |
|
| 2021 |
Jin J, Boeglin WE, Brash AR. Analysis of 12/15-lipoxygenase metabolism of EPA and DHA with special attention to authentication of docosatrienes. Journal of Lipid Research. 100088. PMID 34022182 DOI: 10.1016/j.jlr.2021.100088 |
0.348 |
|
| 2019 |
Takeichi T, Hirabayashi T, Miyasaka Y, Kawamoto A, Okuno Y, Taguchi S, Tanahashi K, Murase C, Takama H, Tanaka K, Boeglin WE, Calcutt MW, Watanabe D, Kono M, Muro Y, ... ... Brash AR, et al. SDR9C7 catalyzes critical dehydrogenation of acylceramides for skin barrier formation. The Journal of Clinical Investigation. PMID 31671075 DOI: 10.1172/Jci130675 |
0.363 |
|
| 2019 |
Kornilov A, Kennedy PD, Aldrovandi M, Watson AJA, Hinz C, Harless B, Colombo J, Maxey KM, Tyrrell VJ, Simon M, Aggarwal VK, Boeglin WE, Brash AR, Murphy RC, O'Donnell VB. Revising the structure of a new eicosanoid from human platelets to 8,9-11,12-diepoxy-13-hydroxy-eicosadienoic acid. The Journal of Biological Chemistry. PMID 31061099 DOI: 10.1074/Jbc.Ra119.008915 |
0.34 |
|
| 2019 |
Pakhomova S, Boeglin WE, Neau DB, Bartlett SG, Brash AR, Newcomer ME. An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. Protein Science : a Publication of the Protein Society. PMID 30861228 DOI: 10.2210/Pdb6Ns2/Pdb |
0.313 |
|
| 2018 |
Davis RW, Allweil A, Tian J, Brash AR, Sulikowski GA. Stereocontrolled synthesis of four isomeric linoleate triols of relevance to skin barrier formation and function. Tetrahedron Letters. 59: 4571-4573. PMID 30906077 DOI: 10.1016/J.Tetlet.2018.11.033 |
0.342 |
|
| 2018 |
Brash AR. Catalase-Related Allene Oxide Synthase, on a Biosynthetic Route to Fatty Acid Cyclopentenones: Expression and Assay of the Enzyme and Preparation of the 8R-HPETE Substrate. Methods in Enzymology. 605: 51-68. PMID 29909837 DOI: 10.1016/Bs.Mie.2018.02.019 |
0.483 |
|
| 2018 |
Yamanashi H, Boeglin WE, Morisseau C, Davis RW, Sulikowski GA, Hammock BD, Brash AR. Catalytic activities of mammalian epoxide hydrolases withandfatty acid epoxides relevant to skin barrier function. Journal of Lipid Research. PMID 29459481 DOI: 10.1194/Jlr.M082701 |
0.524 |
|
| 2017 |
Teder T, Boeglin WE, Brash AR. Oxidation of C18 Hydroxy-Polyunsaturated Fatty Acids to Epoxide or Ketone by Catalase-Related Hemoproteins Activated with Iodosylbenzene. Lipids. PMID 28631071 DOI: 10.1007/S11745-017-4271-0 |
0.492 |
|
| 2017 |
Teder T, Boeglin WE, Schneider C, Brash AR. A fungal catalase reacts selectively with the 13S fatty acid hydroperoxide products of the adjacent lipoxygenase gene and exhibits 13S-hydroperoxide-dependent peroxidase activity. Biochimica Et Biophysica Acta. PMID 28363790 DOI: 10.1016/J.Bbalip.2017.03.011 |
0.499 |
|
| 2017 |
Hirabayashi T, Anjo T, Kaneko A, Senoo Y, Shibata A, Takama H, Yokoyama K, Nishito Y, Ono T, Taya C, Muramatsu K, Fukami K, Muñoz-Garcia A, Brash AR, Ikeda K, et al. PNPLA1 has a crucial role in skin barrier function by directing acylceramide biosynthesis. Nature Communications. 8: 14609. PMID 28248300 DOI: 10.1038/Ncomms14609 |
0.352 |
|
| 2016 |
Mashhadi Z, Newcomer ME, Brash AR. The Thr-His Connection on the Distal Heme of Catalase-Related Hemoproteins: A Hallmark of Reaction with Fatty Acid Hydroperoxides. Chembiochem : a European Journal of Chemical Biology. PMID 27653176 DOI: 10.1002/Cbic.201600345 |
0.471 |
|
| 2016 |
Chiba T, Thomas CP, Calcutt MW, Boeglin WE, O'Donnell VB, Brash AR. The precise structures and stereochemistry of trihydroxy-linoleates esterified in human and porcine epidermis and their significance in skin barrier function: IMPLICATION OF AN EPOXIDE HYDROLASE IN THE TRANSFORMATIONS OF LINOLEATE. The Journal of Biological Chemistry. PMID 27151221 DOI: 10.1074/Jbc.M115.711267 |
0.457 |
|
| 2016 |
Martin SA, Brash AR, Murphy RC. The Discovery and Early Structural Studies of Arachidonic Acid. Journal of Lipid Research. PMID 27142391 DOI: 10.1194/Jlr.R068072 |
0.439 |
|
| 2016 |
Hebert SP, Cha JK, Brash AR, Schlegel HB. Investigation into 9(S)-HPODE-derived allene oxide to cyclopentenone cyclization mechanism via diradical oxyallyl intermediates. Organic & Biomolecular Chemistry. PMID 26976802 DOI: 10.1039/C6Ob00204H |
0.373 |
|
| 2015 |
Mashhadi Z, Boeglin WE, Brash AR. Robust inhibitory effects of conjugated linolenic acids on a cyclooxygenase-related linoleate 10S-dioxygenase: Comparison with COX-1 and COX-2. Biochimica Et Biophysica Acta. 1851: 1346-52. PMID 26209563 DOI: 10.1016/J.Bbalip.2015.07.004 |
0.421 |
|
| 2015 |
Teder T, Lõhelaid H, Boeglin WE, Calcutt WM, Brash AR, Samel N. A Catalase-related Hemoprotein in Coral Is Specialized for Synthesis of Short-chain Aldehydes: DISCOVERY OF P450-TYPE HYDROPEROXIDE LYASE ACTIVITY IN A CATALASE. The Journal of Biological Chemistry. 290: 19823-32. PMID 26100625 DOI: 10.1074/Jbc.M115.660282 |
0.476 |
|
| 2015 |
Newcomer ME, Brash AR. The structural basis for specificity in lipoxygenase catalysis. Protein Science : a Publication of the Protein Society. 24: 298-309. PMID 25524168 DOI: 10.1002/Pro.2626 |
0.459 |
|
| 2014 |
Teder T, Boeglin WE, Brash AR. Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction. Journal of Lipid Research. 55: 2587-96. PMID 25293588 DOI: 10.1194/Jlr.M054072 |
0.466 |
|
| 2014 |
Neau DB, Bender G, Boeglin WE, Bartlett SG, Brash AR, Newcomer ME. Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase. The Journal of Biological Chemistry. 289: 31905-13. PMID 25231982 DOI: 10.1074/Jbc.M114.599662 |
0.453 |
|
| 2014 |
Mashhadi Z, Boeglin WE, Brash AR. Inhibitory effects of a novel Val to Thr mutation on the distal heme of human catalase. Biochimie. 106: 180-3. PMID 25086217 DOI: 10.1016/J.Biochi.2014.07.021 |
0.359 |
|
| 2014 |
Brash AR, Niraula NP, Boeglin WE, Mashhadi Z. An ancient relative of cyclooxygenase in cyanobacteria is a linoleate 10S-dioxygenase that works in tandem with a catalase-related protein with specific 10S-hydroperoxide lyase activity. The Journal of Biological Chemistry. 289: 13101-11. PMID 24659780 DOI: 10.1074/Jbc.M114.555904 |
0.484 |
|
| 2014 |
Muñoz-Garcia A, Thomas CP, Keeney DS, Zheng Y, Brash AR. The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier. Biochimica Et Biophysica Acta. 1841: 401-8. PMID 24021977 DOI: 10.1016/J.Bbalip.2013.08.020 |
0.411 |
|
| 2013 |
Brash AR, Boeglin WE, Stec DF, Voehler M, Schneider C, Cha JK. Isolation and characterization of two geometric allene oxide isomers synthesized from 9S-hydroperoxylinoleic acid by cytochrome P450 CYP74C3: stereochemical assignment of natural fatty acid allene oxides. The Journal of Biological Chemistry. 288: 20797-806. PMID 23709224 DOI: 10.1074/Jbc.M113.482521 |
0.381 |
|
| 2013 |
Jin J, Zheng Y, Brash AR. Demonstration of HNE-related aldehyde formation via lipoxygenase-catalyzed synthesis of a bis-allylic dihydroperoxide intermediate. Chemical Research in Toxicology. 26: 896-903. PMID 23668325 DOI: 10.1021/Tx4000396 |
0.481 |
|
| 2013 |
Thomas CP, Boeglin WE, Garcia-Diaz Y, O'Donnell VB, Brash AR. Steric analysis of epoxyalcohol and trihydroxy derivatives of 9-hydroperoxy-linoleic acid from hematin and enzymatic synthesis. Chemistry and Physics of Lipids. 167: 21-32. PMID 23352713 DOI: 10.1016/J.Chemphyslip.2013.01.002 |
0.461 |
|
| 2013 |
Jin J, Zheng Y, Boeglin WE, Brash AR. Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration. Journal of Lipid Research. 54: 754-61. PMID 23242647 DOI: 10.1194/Jlr.M033746 |
0.395 |
|
| 2012 |
Boeglin WE, Brash AR. Cytochrome P450-type hydroxylation and epoxidation in a tyrosine-liganded hemoprotein, catalase-related allene oxide synthase. The Journal of Biological Chemistry. 287: 24139-47. PMID 22628547 DOI: 10.1074/Jbc.M112.364216 |
0.499 |
|
| 2012 |
Gilbert NC, Rui Z, Neau DB, Waight MT, Bartlett SG, Boeglin WE, Brash AR, Newcomer ME. Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 26: 3222-9. PMID 22516296 DOI: 10.1096/Fj.12-205286 |
0.405 |
|
| 2012 |
Jin J, Boeglin WE, Cha JK, Brash AR. 8R-Lipoxygenase-catalyzed synthesis of a prominent cis-epoxyalcohol from dihomo-γ-linolenic acid: a distinctive transformation compared with S-lipoxygenases. Journal of Lipid Research. 53: 292-9. PMID 22158855 DOI: 10.1194/Jlr.M022863 |
0.478 |
|
| 2012 |
Brash AR, Schneider C, Hamberg M. Applications of stereospecifically-labeled Fatty acids in oxygenase and desaturase biochemistry. Lipids. 47: 101-16. PMID 21971646 DOI: 10.1007/S11745-011-3612-7 |
0.421 |
|
| 2011 |
Zheng Y, Yin H, Boeglin WE, Elias PM, Crumrine D, Beier DR, Brash AR. Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope. The Journal of Biological Chemistry. 286: 24046-56. PMID 21558561 DOI: 10.1074/Jbc.M111.251496 |
0.44 |
|
| 2011 |
Gilbert NC, Bartlett SG, Waight MT, Neau DB, Boeglin WE, Brash AR, Newcomer ME. The structure of human 5-lipoxygenase. Science (New York, N.Y.). 331: 217-9. PMID 21233389 DOI: 10.1126/Science.1197203 |
0.32 |
|
| 2011 |
Liu W, Porter NA, Schneider C, Brash AR, Yin H. Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition. Free Radical Biology & Medicine. 50: 166-78. PMID 21047551 DOI: 10.1016/J.Freeradbiomed.2010.10.709 |
0.38 |
|
| 2010 |
Zheng Y, Brash AR. On the role of molecular oxygen in lipoxygenase activation: comparison and contrast of epidermal lipoxygenase-3 with soybean lipoxygenase-1. The Journal of Biological Chemistry. 285: 39876-87. PMID 20923767 DOI: 10.1074/Jbc.M110.180794 |
0.439 |
|
| 2010 |
Zheng Y, Brash AR. Dioxygenase activity of epidermal lipoxygenase-3 unveiled: typical and atypical features of its catalytic activity with natural and synthetic polyunsaturated fatty acids. The Journal of Biological Chemistry. 285: 39866-75. PMID 20921226 DOI: 10.1074/Jbc.M110.155374 |
0.453 |
|
| 2010 |
Zheng Y, Brash AR. Formation of a cyclopropyl epoxide via a leukotriene A synthase-related pathway in an anaerobic reaction of soybean lipoxygenase-1 with 15S-hydroperoxyeicosatetraenoic acid: evidence that oxygen access is a determinant of secondary reactions with fatty acid hydroperoxides. The Journal of Biological Chemistry. 285: 13427-36. PMID 20194505 DOI: 10.1074/Jbc.M109.084632 |
0.434 |
|
| 2010 |
Gao B, Boeglin WE, Brash AR. Omega-3 fatty acids are oxygenated at the n-7 carbon by the lipoxygenase domain of a fusion protein in the cyanobacterium Acaryochloris marina. Biochimica Et Biophysica Acta. 1801: 58-63. PMID 19786119 DOI: 10.1016/J.Bbalip.2009.09.004 |
0.477 |
|
| 2010 |
YEOLA SN, SALEH SA, BRASH AR, PRAKASH C, TABER DF, BLAIR IA. ChemInform Abstract: Synthesis of (10S)-Hydroxyeicosatetraenoic Acid (VIII): A Novel Cytochrome P-450 Metabolite of Arachidonic Acid. Cheminform. 27: no-no. DOI: 10.1002/chin.199627262 |
0.31 |
|
| 2009 |
Pakhomova S, Gao B, Boeglin WE, Brash AR, Newcomer ME. The structure and peroxidase activity of a 33-kDa catalase-related protein from Mycobacterium avium ssp. paratuberculosis Protein Science. 18: 2559-2568. PMID 19827095 DOI: 10.1002/Pro.265 |
0.355 |
|
| 2009 |
Brash AR. Mechanistic aspects of CYP74 allene oxide synthases and related cytochrome P450 enzymes. Phytochemistry. 70: 1522-31. PMID 19747698 DOI: 10.1016/J.Phytochem.2009.08.005 |
0.362 |
|
| 2009 |
Neau DB, Gilbert NC, Bartlett SG, Boeglin W, Brash AR, Newcomer ME. The 1.85 A structure of an 8R-lipoxygenase suggests a general model for lipoxygenase product specificity. Biochemistry. 48: 7906-15. PMID 19594169 DOI: 10.1021/Bi900084M |
0.435 |
|
| 2009 |
Gao B, Boeglin WE, Zheng Y, Schneider C, Brash AR. Evidence for an ionic intermediate in the transformation of fatty acid hydroperoxide by a catalase-related allene oxide synthase from the Cyanobacterium Acaryochloris marina. The Journal of Biological Chemistry. 284: 22087-98. PMID 19531485 DOI: 10.1074/Jbc.M109.013151 |
0.495 |
|
| 2009 |
Niisuke K, Boeglin WE, Murray JJ, Schneider C, Brash AR. Biosynthesis of a linoleic acid allylic epoxide: mechanistic comparison with its chemical synthesis and leukotriene A biosynthesis. Journal of Lipid Research. 50: 1448-55. PMID 19244216 DOI: 10.1194/Jlr.M900025-Jlr200 |
0.513 |
|
| 2008 |
Boeglin WE, Itoh A, Zheng Y, Coffa G, Howe GA, Brash AR. Investigation of substrate binding and product stereochemistry issues in two linoleate 9-lipoxygenases. Lipids. 43: 979-87. PMID 18795358 DOI: 10.1007/S11745-008-3230-1 |
0.429 |
|
| 2008 |
Gao B, Boeglin WE, Brash AR. Role of the conserved distal heme asparagine of coral allene oxide synthase (Asn137) and human catalase (Asn148): mutations affect the rate but not the essential chemistry of the enzymatic transformations. Archives of Biochemistry and Biophysics. 477: 285-90. PMID 18652800 DOI: 10.1016/J.Abb.2008.07.011 |
0.406 |
|
| 2008 |
Schneider C, Boeglin WE, Yin H, Porter NA, Brash AR. Intermolecular peroxyl radical reactions during autoxidation of hydroxy and hydroperoxy arachidonic acids generate a novel series of epoxidized products. Chemical Research in Toxicology. 21: 895-903. PMID 18324788 DOI: 10.1021/Tx700357U |
0.452 |
|
| 2008 |
Schneider C, Porter NA, Brash AR. Routes to 4-hydroxynonenal: fundamental issues in the mechanisms of lipid peroxidation. The Journal of Biological Chemistry. 283: 15539-43. PMID 18285327 DOI: 10.1074/Jbc.R800001200 |
0.399 |
|
| 2008 |
Zheng Y, Boeglin WE, Schneider C, Brash AR. A 49-kDa mini-lipoxygenase from Anabaena sp. PCC 7120 retains catalytically complete functionality. The Journal of Biological Chemistry. 283: 5138-47. PMID 18070874 DOI: 10.1074/Jbc.M705780200 |
0.468 |
|
| 2008 |
Brash AR, Gao B, Boeglin WE. Synthesis of a novel allene oxide from linolenic acid by a mini-catalase/lipoxygenase fusion protein from the cyanobacterium Acaryochloris marina The Faseb Journal. 22: 327-327. DOI: 10.1096/Fasebj.22.2_Supplement.327 |
0.378 |
|
| 2007 |
Schneider C, Niisuke K, Boeglin WE, Voehler M, Stec DF, Porter NA, Brash AR. Enzymatic synthesis of a bicyclobutane fatty acid by a hemoprotein lipoxygenase fusion protein from the cyanobacterium Anabaena PCC 7120. Proceedings of the National Academy of Sciences of the United States of America. 104: 18941-5. PMID 18025466 DOI: 10.1073/Pnas.0707148104 |
0.471 |
|
| 2007 |
Schneider C, Yu Z, Boeglin WE, Zheng Y, Brash AR. Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by chiral column chromatography. Methods in Enzymology. 433: 145-57. PMID 17954233 DOI: 10.1016/S0076-6879(07)33008-5 |
0.571 |
|
| 2007 |
Rector CL, Stec DF, Brash AR, Porter NA. Identification of the peroxidation products of 13-hydroxy-gamma-linolenate and 15-hydroxyarachidonate: mechanistic studies on the formation of leukotriene-like diols. Chemical Research in Toxicology. 20: 1582-93. PMID 17907784 DOI: 10.1021/Tx700120R |
0.332 |
|
| 2007 |
Valmsen K, Boeglin WE, Järving R, Järving I, Varvas K, Brash AR, Samel N. A critical role of non-active site residues on cyclooxygenase helices 5 and 6 in the control of prostaglandin stereochemistry at carbon 15. The Journal of Biological Chemistry. 282: 28157-63. PMID 17652088 DOI: 10.1074/Jbc.M704950200 |
0.425 |
|
| 2007 |
Brash AR, Yu Z, Boeglin WE, Schneider C. The hepoxilin connection in the epidermis. The Febs Journal. 274: 3494-502. PMID 17608720 DOI: 10.1111/J.1742-4658.2007.05909.X |
0.618 |
|
| 2007 |
Schneider C, Pratt DA, Porter NA, Brash AR. Control of oxygenation in lipoxygenase and cyclooxygenase catalysis. Chemistry & Biology. 14: 473-88. PMID 17524979 DOI: 10.1016/J.Chembiol.2007.04.007 |
0.43 |
|
| 2007 |
Yu Z, Schneider C, Boeglin WE, Brash AR. Epidermal lipoxygenase products of the hepoxilin pathway selectively activate the nuclear receptor PPARalpha. Lipids. 42: 491-7. PMID 17436029 DOI: 10.1007/S11745-007-3054-4 |
0.614 |
|
| 2007 |
Moran JL, Qiu H, Turbe-Doan A, Yun Y, Boeglin WE, Brash AR, Beier DR. A mouse mutation in the 12R-lipoxygenase, Alox12b, disrupts formation of the epidermal permeability barrier. The Journal of Investigative Dermatology. 127: 1893-7. PMID 17429434 DOI: 10.1038/Sj.Jid.5700825 |
0.317 |
|
| 2006 |
Yu Z, Schneider C, Boeglin WE, Brash AR. Human and mouse eLOX3 have distinct substrate specificities: implications for their linkage with lipoxygenases in skin. Archives of Biochemistry and Biophysics. 455: 188-96. PMID 17045234 DOI: 10.1016/J.Abb.2006.09.002 |
0.626 |
|
| 2006 |
Furse KE, Pratt DA, Schneider C, Brash AR, Porter NA, Lybrand TP. Molecular dynamics simulations of arachidonic acid-derived pentadienyl radical intermediate complexes with COX-1 and COX-2: insights into oxygenation regio- and stereoselectivity. Biochemistry. 45: 3206-18. PMID 16519515 DOI: 10.1021/Bi052338H |
0.365 |
|
| 2006 |
Tosha T, Uchida T, Brash AR, Kitagawa T. On the relationship of coral allene oxide synthase to catalase. A single active site mutation that induces catalase activity in coral allene oxide synthase. The Journal of Biological Chemistry. 281: 12610-7. PMID 16513636 DOI: 10.1074/Jbc.M600061200 |
0.33 |
|
| 2006 |
Mortimer M, Järving R, Brash AR, Samel N, Järving I. Identification and characterization of an arachidonate 11R-lipoxygenase. Archives of Biochemistry and Biophysics. 445: 147-55. PMID 16321357 DOI: 10.1016/J.Abb.2005.10.023 |
0.45 |
|
| 2005 |
Schneider C, Boeglin WE, Yin H, Ste DF, Hachey DL, Porter NA, Brash AR. Synthesis of dihydroperoxides of linoleic and linolenic acids and studies on their transformation to 4-hydroperoxynonenal. Lipids. 40: 1155-62. PMID 16459928 DOI: 10.1007/S11745-005-1480-3 |
0.472 |
|
| 2005 |
Oldham ML, Brash AR, Newcomer ME. Insights from the x-ray crystal structure of coral 8R-lipoxygenase: Calcium activation via a C2-like domain and a structural basis of product chirality Journal of Biological Chemistry. 280: 39545-39552. PMID 16162493 DOI: 10.1074/Jbc.M506675200 |
0.444 |
|
| 2005 |
Coffa G, Imber AN, Maguire BC, Laxmikanthan G, Schneider C, Gaffney BJ, Brash AR. On the relationships of substrate orientation, hydrogen abstraction, and product stereochemistry in single and double dioxygenations by soybean lipoxygenase-1 and its Ala542Gly mutant. The Journal of Biological Chemistry. 280: 38756-66. PMID 16157595 DOI: 10.1074/Jbc.M504870200 |
0.465 |
|
| 2005 |
Coffa G, Schneider C, Brash AR. A comprehensive model of positional and stereo control in lipoxygenases. Biochemical and Biophysical Research Communications. 338: 87-92. PMID 16111652 DOI: 10.1016/J.Bbrc.2005.07.185 |
0.415 |
|
| 2005 |
Chang MS, Schneider C, Roberts RL, Shappell SB, Haselton FR, Boeglin WE, Brash AR. Detection and subcellular localization of two 15S-lipoxygenases in human cornea. Investigative Ophthalmology & Visual Science. 46: 849-56. PMID 15728540 DOI: 10.1167/Iovs.04-1166 |
0.346 |
|
| 2005 |
Yu Z, Schneider C, Boeglin WE, Brash AR. Mutations associated with a congenital form of ichthyosis (NCIE) inactivate the epidermal lipoxygenases 12R-LOX and eLOX3. Biochimica Et Biophysica Acta. 1686: 238-47. PMID 15629692 DOI: 10.1016/J.Bbalip.2004.10.007 |
0.582 |
|
| 2005 |
Oldham ML, Brash AR, Newcomer ME. The structure of coral allene oxide synthase reveals a catalase adapted for metabolism of a fatty acid hydroperoxide Proceedings of the National Academy of Sciences of the United States of America. 102: 297-302. PMID 15625113 DOI: 10.1073/Pnas.0406352102 |
0.473 |
|
| 2005 |
Schneider C, Boeglin WE, Brash AR. Human cyclo-oxygenase-1 and an alternative splice variant: contrasts in expression of mRNA, protein and catalytic activities. The Biochemical Journal. 385: 57-64. PMID 15361066 DOI: 10.1042/Bj20041115 |
0.381 |
|
| 2004 |
Coffa G, Brash AR. A single active site residue directs oxygenation stereospecificity in lipoxygenases: stereocontrol is linked to the position of oxygenation. Proceedings of the National Academy of Sciences of the United States of America. 101: 15579-84. PMID 15496467 DOI: 10.1073/Pnas.0406727101 |
0.443 |
|
| 2004 |
Valmsen K, Boeglin WE, Järving I, Schneider C, Varvas K, Brash AR, Samel N. Structural and functional comparison of 15S- and 15R-specific cyclooxygenases from the coral Plexaura homomalla. European Journal of Biochemistry / Febs. 271: 3533-8. PMID 15317588 DOI: 10.1111/J.0014-2956.2004.04289.X |
0.432 |
|
| 2004 |
Schneider C, Porter NA, Brash AR. Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal. Chemical Research in Toxicology. 17: 937-41. PMID 15257619 DOI: 10.1021/Tx049913N |
0.452 |
|
| 2004 |
Schneider C, Strayhorn WD, Brantley DM, Nanney LB, Yull FE, Brash AR. Upregulation of 8-lipoxygenase in the dermatitis of IkappaB-alpha-deficient mice. The Journal of Investigative Dermatology. 122: 691-8. PMID 15086555 DOI: 10.1111/J.0022-202X.2004.22329.X |
0.389 |
|
| 2004 |
Schneider C, Boeglin WE, Brash AR. Identification of two cyclooxygenase active site residues, Leucine 384 and Glycine 526, that control carbon ring cyclization in prostaglandin biosynthesis. The Journal of Biological Chemistry. 279: 4404-14. PMID 14594816 DOI: 10.1074/Jbc.M307431200 |
0.469 |
|
| 2003 |
Yu Z, Schneider C, Boeglin WE, Marnett LJ, Brash AR. The lipoxygenase gene ALOXE3 implicated in skin differentiation encodes a hydroperoxide isomerase. Proceedings of the National Academy of Sciences of the United States of America. 100: 9162-7. PMID 12881489 DOI: 10.1073/Pnas.1633612100 |
0.63 |
|
| 2002 |
Schneider C, Boeglin WE, Brash AR. Analysis of cyclooxygenase-substrate interactions using stereospecifically-labeled arachidonic acids. Advances in Experimental Medicine and Biology. 507: 49-53. PMID 12664563 DOI: 10.1016/S0090-6980(99)90281-2 |
0.375 |
|
| 2002 |
Tijet N, Brash AR. Allene oxide synthases and allene oxides. Prostaglandins & Other Lipid Mediators. 68: 423-31. PMID 12432934 DOI: 10.1016/S0090-6980(02)00046-1 |
0.411 |
|
| 2002 |
Schneider C, Brash AR. Lipoxygenase-catalyzed formation of R-configuration hydroperoxides. Prostaglandins & Other Lipid Mediators. 68: 291-301. PMID 12432924 DOI: 10.1016/S0090-6980(02)00041-2 |
0.452 |
|
| 2002 |
Thuillier P, Brash AR, Kehrer JP, Stimmel JB, Leesnitzer LM, Yang P, Newman RA, Fischer SM. Inhibition of peroxisome proliferator-activated receptor (PPAR)-mediated keratinocyte differentiation by lipoxygenase inhibitors. The Biochemical Journal. 366: 901-10. PMID 12069687 DOI: 10.1042/Bj20020377 |
0.343 |
|
| 2002 |
Kozak KR, Gupta RA, Moody JS, Ji C, Boeglin WE, DuBois RN, Brash AR, Marnett LJ. 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. The Journal of Biological Chemistry. 277: 23278-86. PMID 11956198 DOI: 10.1074/Jbc.M201084200 |
0.364 |
|
| 2002 |
Schneider C, Manier ML, Hachey DL, Brash AR. Detection of the 15-acetate of prostaglandin E2 methyl ester as a prominent component of the prostaglandins in the gorgonian coral Plexaura homomalla. Lipids. 37: 217-21. PMID 11908914 DOI: 10.1007/S11745-002-0883-5 |
0.346 |
|
| 2002 |
Schneider C, Boeglin WE, Prusakiewicz JJ, Rowlinson SW, Marnett LJ, Samel N, Brash AR. Control of prostaglandin stereochemistry at the 15-carbon by cyclooxygenases-1 and -2. A critical role for serine 530 and valine 349. The Journal of Biological Chemistry. 277: 478-85. PMID 11677234 DOI: 10.1074/Jbc.M107471200 |
0.458 |
|
| 2001 |
Valmsen K, Järving I, Boeglin WE, Varvas K, Koljak R, Pehk T, Brash AR, Samel N. The origin of 15R-prostaglandins in the Caribbean coral Plexaura homomalla: molecular cloning and expression of a novel cyclooxygenase. Proceedings of the National Academy of Sciences of the United States of America. 98: 7700-5. PMID 11427702 DOI: 10.1073/Pnas.131022398 |
0.47 |
|
| 2001 |
Brash AR. Arachidonic acid as a bioactive molecule. The Journal of Clinical Investigation. 107: 1339-45. PMID 11390413 DOI: 10.1172/Jci13210 |
0.452 |
|
| 2001 |
Tijet N, Schneider C, Muller BL, Brash AR. Biogenesis of volatile aldehydes from fatty acid hydroperoxides: molecular cloning of a hydroperoxide lyase (CYP74C) with specificity for both the 9- and 13-hydroperoxides of linoleic and linolenic acids. Archives of Biochemistry and Biophysics. 386: 281-9. PMID 11368353 DOI: 10.1006/Abbi.2000.2218 |
0.477 |
|
| 2001 |
Schneider C, Keeney DS, Boeglin WE, Brash AR. Detection and cellular localization of 12R-lipoxygenase in human tonsils. Archives of Biochemistry and Biophysics. 386: 268-74. PMID 11368351 DOI: 10.1006/Abbi.2000.2217 |
0.425 |
|
| 2001 |
Jisaka M, Boeglin WE, Kim RB, Brash AR. Site-directed mutagenesis studies on a putative fifth iron ligand of mouse 8S-lipoxygenase: retention of catalytic activity on mutation of serine-558 to asparagine, histidine, or alanine. Archives of Biochemistry and Biophysics. 386: 136-42. PMID 11368335 DOI: 10.1006/Abbi.2000.2175 |
0.37 |
|
| 2001 |
Schneider C, Tallman KA, Porter NA, Brash AR. Two distinct pathways of formation of 4-hydroxynonenal. Mechanisms of nonenzymatic transformation of the 9- and 13-hydroperoxides of linoleic acid to 4-hydroxyalkenals. The Journal of Biological Chemistry. 276: 20831-8. PMID 11259420 DOI: 10.1074/Jbc.M101821200 |
0.448 |
|
| 2001 |
Brash AR. Autoxidation of methyl linoleate: identification of the bis-allylic 11-hydroperoxide. Lipids. 35: 947-52. PMID 11026614 DOI: 10.1007/S11745-000-0604-0 |
0.393 |
|
| 2000 |
Koljak R, Järving I, Kurg R, Boeglin WE, Varvas K, Valmsen K, Ustav M, Brash AR, Samel N. The basis of prostaglandin synthesis in coral: molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa. The Journal of Biological Chemistry. 276: 7033-40. PMID 11085996 DOI: 10.1074/Jbc.M009803200 |
0.431 |
|
| 2000 |
Tijet N, Waspi U, Gaskin DJH, Hunziker P, Muller BL, Vulfson EN, Slusarenko A, Brash AR, Whitehead IM. Purification, molecular cloning, and expression of the gene encoding fatty acid 13-hydroperoxide lyase from guava fruit (Psidium guajava) Lipids. 35: 709-720. PMID 10941871 DOI: 10.1007/S11745-000-0577-Z |
0.455 |
|
| 2000 |
Schneider C, Boeglin WE, Lai S, Cha JK, Brash AR. Synthesis and applications of stereospecifically (3)H-labeled arachidonic acids as mechanistic probes for lipoxygenase and cyclooxygenase catalysis. Analytical Biochemistry. 284: 125-35. PMID 10933865 DOI: 10.1006/Abio.2000.4670 |
0.461 |
|
| 2000 |
Schneider C, Brash AR. Stereospecificity of hydrogen abstraction in the conversion of arachidonic acid to 15R-HETE by aspirin-treated cyclooxygenase-2. Implications for the alignment of substrate in the active site. The Journal of Biological Chemistry. 275: 4743-6. PMID 10671506 DOI: 10.1074/Jbc.275.7.4743 |
0.469 |
|
| 2000 |
Jisaka M, Kim RB, Boeglin WE, Brash AR. Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2. The Journal of Biological Chemistry. 275: 1287-93. PMID 10625675 DOI: 10.1074/Jbc.275.2.1287 |
0.452 |
|
| 1999 |
Boutaud O, Brash AR. Purification and catalytic activities of the two domains of the allene oxide synthase-lipoxygenase fusion protein of the coral Plexaura homomalla. The Journal of Biological Chemistry. 274: 33764-70. PMID 10559269 DOI: 10.1074/Jbc.274.47.33764 |
0.414 |
|
| 1999 |
Varvas K, Järving I, Koljak R, Valmsen K, Brash AR, Samel N. Evidence of a cyclooxygenase-related prostaglandin synthesis in coral. The allene oxide pathway is not involved in prostaglandin biosynthesis. The Journal of Biological Chemistry. 274: 9923-9. PMID 10187766 DOI: 10.1074/Jbc.274.15.9923 |
0.471 |
|
| 1999 |
Brash AR, Jisaka M, Boeglin WE, Chang MS. Molecular cloning of a second human 15S-lipoxygenase and its murine homologue, an 8S-lipoxygenase. Their relationship to other mammalian lipoxygenases. Advances in Experimental Medicine and Biology. 447: 29-36. PMID 10086180 DOI: 10.1007/978-1-4615-4861-4_3 |
0.355 |
|
| 1999 |
Boeglin WE, Schneider C, Keeney DS, Nanney LB, Brash AR. Catalytic activity of human 12R-lipoxygenase and its expression in psoriasis and tonsils Prostaglandins & Other Lipid Mediators. 59: 228. DOI: 10.1016/S0090-6980(99)90463-X |
0.343 |
|
| 1999 |
Jisaka M, Kim RB, Boeglin WE, Brash AR. Identification of two amino acids critical for the positional specificity of mouse 8S-lipoxygenase: mutation to the 15-lipoxygenase-2 sequence changes specificity to oxygenation at C-15 Prostaglandins & Other Lipid Mediators. 59: 181. DOI: 10.1016/S0090-6980(99)90416-1 |
0.364 |
|
| 1998 |
Boeglin WE, Kim RB, Brash AR. A 12R-lipoxygenase in human skin: mechanistic evidence, molecular cloning, and expression. Proceedings of the National Academy of Sciences of the United States of America. 95: 6744-9. PMID 9618483 DOI: 10.1073/Pnas.95.12.6744 |
0.449 |
|
| 1998 |
Yamamoto S, Takahashi Y, Hada T, Hagiya H, Suzuki H, Reddy GR, Ueda N, Arakawa T, Nakamura M, Matsuda S, Taketani Y, Yoshimoto T, Azekawa T, Morita Y, Ishimura K, ... ... Brash AR, et al. Mammalian arachidonate 12-lipoxygenases. Advances in Experimental Medicine and Biology. 127-31. PMID 9547547 DOI: 10.1007/978-1-4615-5325-0_18 |
0.304 |
|
| 1997 |
Jisaka M, Kim RB, Boeglin WE, Nanney LB, Brash AR. Molecular cloning and functional expression of a phorbol ester-inducible 8S-lipoxygenase from mouse skin. The Journal of Biological Chemistry. 272: 24410-6. PMID 9305900 DOI: 10.1074/Jbc.272.39.24410 |
0.414 |
|
| 1997 |
Koljak R, Boutaud O, Shieh BH, Samel N, Brash AR. Identification of a naturally occurring peroxidase-lipoxygenase fusion protein. Science (New York, N.Y.). 277: 1994-6. PMID 9302294 DOI: 10.1126/Science.277.5334.1994 |
0.426 |
|
| 1997 |
Hada T, Swift LL, Brash AR. Discovery of 5R-lipoxygenase activity in oocytes of the surf clam, Spisula solidissima. Biochimica Et Biophysica Acta. 1346: 109-19. PMID 9219894 DOI: 10.1016/S0005-2760(96)00179-8 |
0.489 |
|
| 1997 |
Brash AR, Boeglin WE, Chang MS. Discovery of a second 15S-lipoxygenase in humans. Proceedings of the National Academy of Sciences of the United States of America. 94: 6148-52. PMID 9177185 DOI: 10.1073/Pnas.94.12.6148 |
0.449 |
|
| 1997 |
Brash AR, Song W. Detection, assay, and isolation of allene oxide synthase. Methods in Enzymology. 272: 250-9. PMID 8791784 DOI: 10.1016/S0076-6879(96)72030-X |
0.411 |
|
| 1996 |
Funk CD, Keeney DS, Oliw EH, Boeglin WE, Brash AR. Functional expression and cellular localization of a mouse epidermal lipoxygenase. The Journal of Biological Chemistry. 271: 23338-44. PMID 8798535 DOI: 10.1074/Jbc.271.38.23338 |
0.357 |
|
| 1996 |
Brash AR, Boeglin WE, Chang MS, Shieh BH. Purification and molecular cloning of an 8R-lipoxygenase from the coral Plexaura homomalla reveal the related primary structures of R- and S-lipoxygenases. The Journal of Biological Chemistry. 271: 20949-57. PMID 8702854 DOI: 10.1074/Jbc.271.34.20949 |
0.463 |
|
| 1996 |
Legrand AB, Wang J, Sobo G, Blair IA, Brash AR, Oates JA. Incorporation of 12(S)-hydroxyeicosatetraenoic acid into the phosphatidylcholine signaling pathway. Biochimica Et Biophysica Acta. 1301: 150-60. PMID 8652650 DOI: 10.1016/0005-2760(96)00015-X |
0.381 |
|
| 1996 |
Chang MS, Boeglin WE, Guengerich FP, Brash AR. Cytochrome P450-dependent transformations of 15R- and 15S-hydroperoxyeicosatetraenoic acids: stereoselective formation of epoxy alcohol products. Biochemistry. 35: 464-71. PMID 8555216 DOI: 10.1021/bi952081v |
0.322 |
|
| 1996 |
Yeola SN, Saleh SA, Brash AR, Prakash C, Taber DF, Blair IA. Synthesis of 10(S)-hydroxyeicosatetraenoic acid: A novel cytochrome P-450 metabolite of arachidonic acid Journal of Organic Chemistry. 61: 838-841. DOI: 10.1021/Jo951061W |
0.451 |
|
| 1995 |
Brash AR, Boeglin WE, Capdevila JH, Yeola S, Blair IA. 7-HETE, 10-HETE, and 13-HETE are major products of NADPH-dependent arachidonic acid metabolism in rat liver microsomes: analysis of their stereochemistry, and the stereochemistry of their acid-catalyzed rearrangement. Archives of Biochemistry and Biophysics. 321: 485-92. PMID 7646075 DOI: 10.1006/Abbi.1995.1421 |
0.48 |
|
| 1993 |
Song WC, Funk CD, Brash AR. Molecular cloning of an allene oxide synthase: a cytochrome P450 specialized for the metabolism of fatty acid hydroperoxides. Proceedings of the National Academy of Sciences of the United States of America. 90: 8519-23. PMID 8378325 DOI: 10.1073/Pnas.90.18.8519 |
0.425 |
|
| 1993 |
Chen XS, Brash AR, Funk CD. Purification and characterization of recombinant histidine-tagged human platelet 12-lipoxygenase expressed in a baculovirus/insect cell system. European Journal of Biochemistry. 214: 845-52. PMID 8319693 DOI: 10.1111/J.1432-1033.1993.Tb17988.X |
0.405 |
|
| 1993 |
Takahashi Y, Glasgow WC, Suzuki H, Taketani Y, Yamamoto S, Anton M, Kühn H, Brash AR. Investigation of the oxygenation of phospholipids by the porcine leukocyte and human platelet arachidonate 12-lipoxygenases. European Journal of Biochemistry. 218: 165-71. PMID 8243462 DOI: 10.1111/J.1432-1033.1993.Tb18362.X |
0.478 |
|
| 1991 |
Hughes MA, Brash AR. Investigation of the mechanism of biosynthesis of 8-hydroxyeicosatetraenoic acid in mouse skin. Biochimica Et Biophysica Acta. 1081: 347-54. PMID 1900207 DOI: 10.1016/0005-2760(91)90292-P |
0.464 |
|
| 1991 |
Song WC, Brash AR. Purification of an allene oxide synthase and identification of the enzyme as a cytochrome P-450. Science (New York, N.Y.). 253: 781-4. PMID 1876834 DOI: 10.1126/Science.1876834 |
0.429 |
|
| 1991 |
Song WC, Brash AR. Investigation of the allene oxide pathway in the coral Plexaura homomalla: formation of novel ketols and isomers of prostaglandin A2 from 15-hydroxyeicosatetraenoic acid. Archives of Biochemistry and Biophysics. 290: 427-35. PMID 1681785 DOI: 10.1016/0003-9861(91)90562-W |
0.499 |
|
| 1989 |
Brash AR, Yokoyama C, Oates JA, Yamamoto S. Mechanistic studies of the dioxygenase and leukotriene synthase activities of the porcine leukocyte 12S-lipoxygenase. Archives of Biochemistry and Biophysics. 273: 414-22. PMID 2774560 DOI: 10.1016/0003-9861(89)90500-6 |
0.417 |
|
| 1989 |
Hawkins DJ, Brash AR. Mechanism of biosynthesis of 11R-and 12R-hydroxyeicosatetraenoic acids by eggs of the sea urchin Strongylocentrotus purpuratus. Febs Letters. 247: 9-12. PMID 2495992 DOI: 10.1016/0014-5793(89)81228-1 |
0.412 |
|
| 1989 |
Hawkins DJ, Brash AR. Lipoxygenase metabolism of polyunsaturated fatty acids in oocytes of the frog Xenopus laevis. Archives of Biochemistry and Biophysics. 268: 447-55. PMID 2492416 DOI: 10.1016/0003-9861(89)90312-3 |
0.443 |
|
| 1989 |
Brash AR. Formation of an allene oxide from (8R)-8-hydroperoxyeicosatetraenoic acid in the coral Plexaura homomalla Journal of the American Chemical Society. 111: 1891-1892. DOI: 10.1021/Ja00187A060 |
0.437 |
|
| 1989 |
BRASH AR. ChemInform Abstract: Formation of an Allene Oxide (II) from (8R)-8-Hydroperoxyeicosatetraenoic Acid (I) in the Coral Plexaura homomalla Cheminform. 20. DOI: 10.1002/chin.198923312 |
0.304 |
|
| 1988 |
Baertschi SW, Ingram CD, Harris TM, Brash AR. Absolute configuration of cis-12-oxophytodienoic acid of flaxseed: Implications for the mechanism of biosynthesis from the 13(S)-hydroperoxide of linolenic acid Biochemistry. 27: 18-24. PMID 3349025 DOI: 10.1021/Bi00401A004 |
0.355 |
|
| 1988 |
Hawkins DJ, Kühn H, Petty EH, Brash AR. Resolution of enantiomers of hydroxyeicosatetraenoate derivatives by chiral phase high-pressure liquid chromatography. Analytical Biochemistry. 173: 456-62. PMID 3189822 DOI: 10.1016/0003-2697(88)90214-X |
0.335 |
|
| 1988 |
Kühn H, Schewe T, Rapoport SM, Brash AR. Enzymatic lipid peroxidation: a step in the breakdown of mitochondria during the maturation of red blood cells. Basic Life Sciences. 49: 945-9. PMID 3150671 DOI: 10.1007/978-1-4684-5568-7_154 |
0.339 |
|
| 1988 |
Murray JJ, Brash AR. Rabbit reticulocyte lipoxygenase catalyzes specific 12(S) and 15(S) oxygenation of arachidonoyl-phosphatidylcholine. Archives of Biochemistry and Biophysics. 265: 514-23. PMID 3138949 DOI: 10.1016/0003-9861(88)90156-7 |
0.414 |
|
| 1988 |
Kühn H, Brash AR, Wiesner R, Alder L. Lipoxygenase catalyzed oxygenation of hydroxy fatty acids to lipoxins. Advances in Experimental Medicine and Biology. 229: 39-49. PMID 3138902 DOI: 10.1007/978-1-4757-0937-7_4 |
0.463 |
|
| 1988 |
Brash AR, Baertschi SW, Ingram CD, Harris TM. Isolation and characterization of natural allene oxides: Unstable intermediates in the metabolism of lipid hydroperoxides Proceedings of the National Academy of Sciences of the United States of America. 85: 3382-3386. PMID 2835769 DOI: 10.1073/Pnas.85.10.3382 |
0.46 |
|
| 1987 |
Ueda N, Yokoyama C, Yamamoto S, Fitzsimmons BJ, Rokach J, Oates JA, Brash AR. Lipoxin synthesis by arachidonate 12-lipoxygenase purified from porcine leukocytes Biochemical and Biophysical Research Communications. 149: 1063-1069. PMID 3122743 DOI: 10.1016/0006-291X(87)90516-X |
0.481 |
|
| 1987 |
Kühn H, Wiesner R, Alder L, Fitzsimmons BJ, Rokach J, Brash AR. Formation of lipoxin B by the pure reticulocyte lipoxygenase via sequential oxygenation of the substrate European Journal of Biochemistry. 169: 593-601. PMID 3121318 DOI: 10.1111/J.1432-1033.1987.Tb13650.X |
0.365 |
|
| 1987 |
Brash AR, Ingram CD, Harris TM. Analysis of a specific oxygenation reaction of soybean lipoxygenase-1 with fatty acids esterified in phospholipids Biochemistry. 26: 5465-5471. PMID 3118947 DOI: 10.1021/Bi00391A038 |
0.446 |
|
| 1986 |
Murray JJ, Tonnel AB, Brash AR, Roberts LJ, Gosset P, Workman R, Capron A, Oates JA. Release of prostaglandin D2 into human airways during acute antigen challenge. The New England Journal of Medicine. 315: 800-4. PMID 3462506 DOI: 10.1056/Nejm198609253151304 |
0.305 |
|
| 1986 |
Brash AR, Ingram CD. Lipoxygenase metabolism of endogenous and exogenous arachidonate in leukocytes: GC-MS analyses of incubations in H218O buffers Prostaglandins, Leukotrienes and Medicine. 23: 149-154. PMID 3094028 DOI: 10.1016/0262-1746(86)90178-2 |
0.419 |
|
| 1986 |
Brash AR, Ingram CD, Maas RL. A secondary isotope effect in the lipoxygenase reaction Biochimica Et Biophysica Acta (Bba)/Lipids and Lipid Metabolism. 875: 256-261. PMID 3080027 DOI: 10.1016/0005-2760(86)90175-X |
0.414 |
|
| 1986 |
Ueda N, Yamamoto S, Oates JA, Brash AR. Stereoselective hydrogen abstraction in leukotriene A4 synthesis by purified 5-lipoxygenase of porcine leukocytes. Prostaglandins. 32: 43-8. PMID 3020619 DOI: 10.1016/0090-6980(86)90141-3 |
0.403 |
|
| 1986 |
Gerzer R, Brash AR, Hardman JG. Activation of soluble guanylate cyclase by arachidonic acid and 15-lipoxygenase products. Biochimica Et Biophysica Acta. 886: 383-9. PMID 2871867 DOI: 10.1016/0167-4889(86)90173-4 |
0.475 |
|
| 1985 |
Lawson JA, Brash AR, Doran J, FitzGerald GA. Measurement of urinary 2,3-dinor-thromboxane B2 and thromboxane B2 using bonded-phase phenylboronic acid columns and capillary gas chromatography-negative-ion chemical ionization mass spectrometry Analytical Biochemistry. 150: 463-470. PMID 4091270 DOI: 10.1016/0003-2697(85)90536-6 |
0.304 |
|
| 1985 |
Beckman JK, Gay JC, Brash AR, Lukens JN, Oates JA. Stimulation by lipoxygenase products of superoxide anion production in FMLP-treated neutrophils. Lipids. 20: 318-21. PMID 2989652 DOI: 10.1007/Bf02534265 |
0.344 |
|
| 1983 |
Turk J, Rand TH, Maas RL, Lawson JA, Brash AR, Roberts LJ, Colley DG, Oates JA. Identification of lipoxygenase products from arachidonic acid metabolism in stimulated murine eosinophils. Biochimica Et Biophysica Acta. 750: 78-90. PMID 6402030 DOI: 10.1016/0005-2760(83)90206-0 |
0.4 |
|
| 1983 |
Maas RL, Brash AR. Evidence for a lipoxygenase mechanism in the biosynthesis of epoxide and dihydroxy leukotrienes from 15(S)-hydroperoxyicosatetraenoic acid by human platelets and porcine leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 80: 2884-8. PMID 6304687 DOI: 10.1073/Pnas.80.10.2884 |
0.422 |
|
| 1982 |
Brash AR. Quantitation of the major urinary metabolite of PGF2 alpha in the human by GC-MS. Methods in Enzymology. 86: 579-85. PMID 6957704 DOI: 10.1016/0076-6879(82)86228-9 |
0.342 |
|
| 1982 |
Falardeau P, Brash AR. Quantitation of two dinor metabolites of prostacyclin by GC-MS. Methods in Enzymology. 86: 585-92. PMID 6752645 DOI: 10.1016/0076-6879(82)86229-0 |
0.302 |
|
| 1982 |
Maas RL, Brash AR, Oates JA. A second pathway of leukotriene biosynthesis in porcine leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 78: 5523-27. PMID 6272308 DOI: 10.1073/Pnas.78.9.5523 |
0.441 |
|
| 1981 |
Boeynaems JM, Brash AR, Oates JA, Hubbard WC. Preparation and assay of monohydroxy-eicosatetraenoic acids. Analytical Biochemistry. 104: 259-67. PMID 7004263 DOI: 10.1016/0003-2697(80)90073-1 |
0.383 |
|
| 1980 |
Hubbard WC, Hough AJ, Brash AR, Watson JT, Oates JA. Metabolism of linoleic and arachidonic acids in VX2 carcinoma tissue: identification of monohydroxy octadecadienoic acids and monohydroxy eicosatetraenoic acids. Prostaglandins. 20: 431-47. PMID 6775354 DOI: 10.1016/0090-6980(80)90031-3 |
0.456 |
|
| 1979 |
Brash AR, Baillie TA. The identification of 5beta,7alpha-dihydroxy-11-oxotetranor-prostane-1,16-dioic acid as a urinary metabolite of prostaglandin F2alpha in the rat. Biochimica Et Biophysica Acta. 572: 371-5. PMID 427184 DOI: 10.1016/0005-2760(79)90053-5 |
0.303 |
|
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