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Richard O. Hynes - Publications

Massachusetts Institute of Technology, Cambridge, MA, United States 
Integrins, Focal Adhesion

245 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Murphy PA, Jailkhani N, Nicholas SA, Del Rosario AM, Balsbaugh JL, Begum S, Kimble A, Hynes RO. Alternative Splicing of FN (Fibronectin) Regulates the Composition of the Arterial Wall Under Low Flow. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314013. PMID 33207933 DOI: 10.1161/ATVBAHA.120.314013  0.4
2018 Murphy PA, Butty VL, Boutz PL, Begum S, Kimble AL, Sharp PA, Burge CB, Hynes RO. Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow. Elife. 7. PMID 29293084 DOI: 10.7554/eLife.29494  0.4
2017 Ragelle H, Naba A, Larson BL, Zhou F, Prijić M, Whittaker CA, Del Rosario A, Langer R, Hynes RO, Anderson DG. Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials. 128: 147-159. PMID 28327460 DOI: 10.1016/j.biomaterials.2017.03.008  0.56
2015 Shaw Bagnall J, Byun S, Begum S, Miyamoto DT, Hecht VC, Maheswaran S, Stott SL, Toner M, Hynes RO, Manalis SR. Deformability of Tumor Cells versus Blood Cells. Scientific Reports. 5: 18542. PMID 26679988 DOI: 10.1038/srep18542  0.4
2015 Naba A, Clauser KR, Ding H, Whittaker CA, Carr SA, Hynes RO. The extracellular matrix: Tools and insights for the "omics" era. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26163349 DOI: 10.1016/j.matbio.2015.06.003  1
2015 Murphy PA, Begum S, Hynes RO. Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors. Plos One. 10: e0120872. PMID 25807551 DOI: 10.1371/journal.pone.0120872  1
2015 Turner CJ, Badu-Nkansah K, Crowley D, van der Flier A, Hynes RO. α5 and αv integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo. Development (Cambridge, England). 142: 797-808. PMID 25670798 DOI: 10.1242/dev.117572  1
2014 Hynes RO. Stretching the boundaries of extracellular matrix research. Nature Reviews. Molecular Cell Biology. 15: 761-3. PMID 25574535 DOI: 10.1038/nrm3908  1
2014 Naba A, Clauser KR, Whittaker CA, Carr SA, Tanabe KK, Hynes RO. Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. Bmc Cancer. 14: 518. PMID 25037231 DOI: 10.1186/1471-2407-14-518  1
2014 Labelle M, Begum S, Hynes RO. Platelets guide the formation of early metastatic niches. Proceedings of the National Academy of Sciences of the United States of America. 111: E3053-61. PMID 25024172 DOI: 10.1073/pnas.1411082111  1
2014 Murphy PA, Hynes RO. Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall. Arteriosclerosis, Thrombosis, and Vascular Biology. 34: 2042-50. PMID 24903094 DOI: 10.1161/ATVBAHA.114.303879  1
2014 Turner CJ, Badu-Nkansah K, Crowley D, van der Flier A, Hynes RO. Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation. Developmental Biology. 392: 381-92. PMID 24858485 DOI: 10.1016/j.ydbio.2014.05.006  1
2013 Yao X, Labelle M, Lamb CR, Dugan JM, Williamson CA, Spencer DR, Christ KR, Keating RO, Lee WD, Paradis GA, Begum S, Hynes RO, Wittrup KD. Determination of 35 cell surface antigen levels in malignant pleural effusions identifies CD24 as a marker of disseminated tumor cells. International Journal of Cancer. Journal International Du Cancer. 133: 2925-33. PMID 23775727 DOI: 10.1002/ijc.28312  0.4
2012 Labelle M, Hynes RO. The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discovery. 2: 1091-9. PMID 23166151 DOI: 10.1158/2159-8290.CD-12-0329  1
2012 Lamar JM, Stern P, Liu H, Schindler JW, Jiang ZG, Hynes RO. The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Proceedings of the National Academy of Sciences of the United States of America. 109: E2441-50. PMID 22891335 DOI: 10.1073/pnas.1212021109  1
2012 Hynes RO. The evolution of metazoan extracellular matrix. The Journal of Cell Biology. 196: 671-9. PMID 22431747 DOI: 10.1083/jcb.201109041  1
2012 Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Molecular & Cellular Proteomics : McP. 11: M111.014647. PMID 22159717 DOI: 10.1074/mcp.M111.014647  1
2012 Hynes RO, Naba A. Overview of the matrisome--an inventory of extracellular matrix constituents and functions. Cold Spring Harbor Perspectives in Biology. 4: a004903. PMID 21937732 DOI: 10.1101/cshperspect.a004903  1
2011 Hynes RO. Metastatic cells will take any help they can get. Cancer Cell. 20: 689-90. PMID 22172715 DOI: 10.1016/j.ccr.2011.11.022  1
2011 Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell. 20: 576-90. PMID 22094253 DOI: 10.1016/j.ccr.2011.09.009  1
2011 Stenzel D, Lundkvist A, Sauvaget D, Busse M, Graupera M, van der Flier A, Wijelath ES, Murray J, Sobel M, Costell M, Takahashi S, Fässler R, Yamaguchi Y, Gutmann DH, Hynes RO, et al. Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis. Development (Cambridge, England). 138: 4451-63. PMID 21880786 DOI: 10.1242/dev.071381  1
2011 Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes RO, Xu L. GPR56 Regulates VEGF production and angiogenesis during melanoma progression. Cancer Research. 71: 5558-68. PMID 21724588 DOI: 10.1158/0008-5472.CAN-10-4543  1
2011 Xie L, Duncan MB, Pahler J, Sugimoto H, Martino M, Lively J, Mundel T, Soubasakos M, Rubin K, Takeda T, Inoue M, Lawler J, Hynes RO, Hanahan D, Kalluri R. Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proceedings of the National Academy of Sciences of the United States of America. 108: 9939-44. PMID 21622854 DOI: 10.1073/pnas.1105041108  1
2011 Pulina MV, Hou SY, Mittal A, Julich D, Whittaker CA, Holley SA, Hynes RO, Astrof S. Essential roles of fibronectin in the development of the left-right embryonic body plan. Developmental Biology. 354: 208-20. PMID 21466802 DOI: 10.1016/j.ydbio.2011.03.026  1
2011 Liu H, Ong SE, Badu-Nkansah K, Schindler J, White FM, Hynes RO. CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proceedings of the National Academy of Sciences of the United States of America. 108: 1379-84. PMID 21220330 DOI: 10.1073/pnas.1017228108  1
2010 Acharya M, Mukhopadhyay S, Païdassi H, Jamil T, Chow C, Kissler S, Stuart LM, Hynes RO, Lacy-Hulbert A. αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. The Journal of Clinical Investigation. 120: 4445-52. PMID 21099114 DOI: 10.1172/JCI43796  1
2010 Canault M, Certel K, Schatzberg D, Wagner DD, Hynes RO. The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation. Plos One. 5: e13433. PMID 20976179 DOI: 10.1371/journal.pone.0013433  1
2010 van der Flier A, Badu-Nkansah K, Whittaker CA, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO. Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development (Cambridge, England). 137: 2439-49. PMID 20570943 DOI: 10.1242/dev.049551  1
2010 Xu L, Begum S, Barry M, Crowley D, Yang L, Bronson RT, Hynes RO. GPR56 plays varying roles in endogenous cancer progression. Clinical & Experimental Metastasis. 27: 241-9. PMID 20333450 DOI: 10.1007/s10585-010-9322-3  1
2010 Marchetti G, Escuin S, van der Flier A, De Arcangelis A, Hynes RO, Georges-Labouesse E. Integrin alpha5beta1 is necessary for regulation of radial migration of cortical neurons during mouse brain development. The European Journal of Neuroscience. 31: 399-409. PMID 20105241 DOI: 10.1111/j.1460-9568.2009.07072.x  1
2009 Hynes RO. The extracellular matrix: not just pretty fibrils. Science (New York, N.Y.). 326: 1216-9. PMID 19965464 DOI: 10.1126/science.1176009  1
2009 Hori Y, Stern PJ, Hynes RO, Irvine DJ. Engulfing tumors with synthetic extracellular matrices for cancer immunotherapy. Biomaterials. 30: 6757-67. PMID 19766305 DOI: 10.1016/j.biomaterials.2009.08.037  1
2009 Sobolev O, Stern P, Lacy-Hulbert A, Hynes RO. Natural killer cells require selectins for suppression of subcutaneous tumors. Cancer Research. 69: 2531-9. PMID 19258505 DOI: 10.1158/0008-5472.CAN-08-3126  1
2009 Astrof S, Hynes RO. Fibronectins in vascular morphogenesis. Angiogenesis. 12: 165-75. PMID 19219555 DOI: 10.1007/s10456-009-9136-6  1
2008 Hynes RO. US policies on human embryonic stem cells. Nature Reviews. Molecular Cell Biology. 9: 993-7. PMID 18843274 DOI: 10.1038/nrm2528  1
2008 Stern P, Astrof S, Erkeland SJ, Schustak J, Sharp PA, Hynes RO. A system for Cre-regulated RNA interference in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 13895-900. PMID 18779577 DOI: 10.1073/pnas.0806907105  1
2008 Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, Piao X. GPR56 regulates pial basement membrane integrity and cortical lamination. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5817-26. PMID 18509043 DOI: 10.1523/JNEUROSCI.0853-08.2008  1
2008 Xu L, Shen SS, Hoshida Y, Subramanian A, Ross K, Brunet JP, Wagner SN, Ramaswamy S, Mesirov JP, Hynes RO. Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Molecular Cancer Research : McR. 6: 760-9. PMID 18505921 DOI: 10.1158/1541-7786.MCR-07-0344  1
2008 McCarty JH, Barry M, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO. Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. The American Journal of Pathology. 172: 1740-7. PMID 18467691 DOI: 10.2353/ajpath.2008.070700  1
2008 Wong SY, Crowley D, Bronson RT, Hynes RO. Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer. Clinical & Experimental Metastasis. 25: 109-18. PMID 18058030 DOI: 10.1007/s10585-007-9126-2  1
2008 Shinde AV, Bystroff C, Wang C, Vogelezang MG, Vincent PA, Hynes RO, Van De Water L. Identification of the peptide sequences within the EIIIA (EDA) segment of fibronectin that mediate integrin alpha9beta1-dependent cellular activities. The Journal of Biological Chemistry. 283: 2858-70. PMID 17967897 DOI: 10.1074/jbc.M708306200  1
2008 Eshghi S, Vogelezang MG, Hynes RO, Griffith LG, Lodish HF. α4β1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: Integrins in red cell development (Journal of Cell Biology (2007) 177, 5, (871-880)) Journal of Cell Biology. 181: 395. DOI: 10.1083/jcb.20070208020080326a  1
2007 Izawa A, Ueno T, Jurewicz M, Ito T, Tanaka K, Takahashi M, Ikeda U, Sobolev O, Fiorina P, Smith RN, Hynes RO, Abdi R. Importance of donor- and recipient-derived selectins in cardiac allograft rejection. Journal of the American Society of Nephrology : Jasn. 18: 2929-36. PMID 17928506 DOI: 10.1681/ASN.2006111261  1
2007 Hynes R. Reply to 'UK set to reverse stance on research with chimeras'. Nature Medicine. 13: 1133. PMID 17917652 DOI: 10.1038/nm1007-1133  1
2007 Lacy-Hulbert A, Smith AM, Tissire H, Barry M, Crowley D, Bronson RT, Roes JT, Savill JS, Hynes RO. Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proceedings of the National Academy of Sciences of the United States of America. 104: 15823-8. PMID 17895374 DOI: 10.1073/pnas.0707421104  1
2007 Astrof S, Crowley D, Hynes RO. Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Developmental Biology. 311: 11-24. PMID 17706958 DOI: 10.1016/j.ydbio.2007.07.005  1
2007 Wong SY, Haack H, Kissil JL, Barry M, Bronson RT, Shen SS, Whittaker CA, Crowley D, Hynes RO. Protein 4.1B suppresses prostate cancer progression and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 104: 12784-9. PMID 17640904 DOI: 10.1073/pnas.0705499104  1
2007 Hynes RO. Cell-matrix adhesion in vascular development. Journal of Thrombosis and Haemostasis : Jth. 5: 32-40. PMID 17635706 DOI: 10.1111/j.1538-7836.2007.02569.x  1
2007 Astrof S, Kirby A, Lindblad-Toh K, Daly M, Hynes RO. Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four. Mechanisms of Development. 124: 551-8. PMID 17628448 DOI: 10.1016/j.mod.2007.05.004  1
2007 Eshghi S, Vogelezang MG, Hynes RO, Griffith LG, Lodish HF. Alpha4beta1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: integrins in red cell development. The Journal of Cell Biology. 177: 871-80. PMID 17548514 DOI: 10.1083/jcb.200702080  1
2007 Lacy-Hulbert A, Ueno T, Ito T, Jurewicz M, Izawa A, Smith RN, Chase CM, Tanaka K, Fiorina P, Russell PS, Auchincloss H, Sayegh MH, Hynes RO, Abdi R. Beta 3 integrins regulate lymphocyte migration and cytokine responses in heart transplant rejection. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7: 1080-90. PMID 17359504 DOI: 10.1111/j.1600-6143.2007.01757.x  1
2007 Xu L, Hynes RO. GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle (Georgetown, Tex.). 6: 160-5. PMID 17314516 DOI: 10.4161/cc.6.2.3760  1
2007 Wong SY, Hynes RO. Tumor-lymphatic interactions in an activated stromal microenvironment. Journal of Cellular Biochemistry. 101: 840-50. PMID 17177186 DOI: 10.1002/jcb.21146  1
2007 Zou Z, Chen H, Schmaier AA, Hynes RO, Kahn ML. Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets. Blood. 109: 3284-90. PMID 17170121 DOI: 10.1182/blood-2006-10-051664  1
2007 Mc Carty JH, Hynes RO. Endothelial cell integrins Endothelial Biomedicine. 707-713. DOI: 10.1017/CBO9780511546198.078  1
2006 Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, ... ... Hynes RO, et al. The genome of the sea urchin Strongylocentrotus purpuratus. Science (New York, N.Y.). 314: 941-52. PMID 17095691 DOI: 10.1126/science.1133609  0.56
2006 Whittaker CA, Bergeron KF, Whittle J, Brandhorst BP, Burke RD, Hynes RO. The echinoderm adhesome. Developmental Biology. 300: 252-66. PMID 16950242 DOI: 10.1016/j.ydbio.2006.07.044  1
2006 Yang H, Reheman A, Chen P, Zhu G, Hynes RO, Freedman J, Wagner DD, Ni H. Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. Journal of Thrombosis and Haemostasis : Jth. 4: 2230-7. PMID 16824188 DOI: 10.1111/j.1538-7836.2006.02116.x  1
2006 Xu L, Begum S, Hearn JD, Hynes RO. GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 103: 9023-8. PMID 16757564 DOI: 10.1073/pnas.0602681103  1
2006 Wong SY, Hynes RO. Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide? Cell Cycle (Georgetown, Tex.). 5: 812-7. PMID 16627996  1
2006 Matuskova J, Chauhan AK, Cambien B, Astrof S, Dole VS, Piffath CL, Hynes RO, Wagner DD. Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Arteriosclerosis, Thrombosis, and Vascular Biology. 26: 1391-6. PMID 16528004 DOI: 10.1161/01.ATV.0000216282.58291.c6  1
2006 Staquet MJ, Couble ML, Roméas A, Connolly M, Magloire H, Hynes RO, Clezardin P, Bleicher F, Farges JC. Expression and localisation of alphav integrins in human odontoblasts. Cell and Tissue Research. 323: 457-63. PMID 16341551 DOI: 10.1007/s00441-005-0104-1  1
2006 Ni H, Chen P, Spring CM, Sayeh E, Semple JW, Lazarus AH, Hynes RO, Freedman J. A novel murine model of fetal and neonatal alloimmune thrombocytopenia: response to intravenous IgG therapy. Blood. 107: 2976-83. PMID 16317099 DOI: 10.1182/blood-2005-06-2562  1
2005 Taverna D, Crowley D, Connolly M, Bronson RT, Hynes RO. A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas. Cancer Research. 65: 10324-9. PMID 16288021 DOI: 10.1158/0008-5472.CAN-04-4098  1
2005 Wong SY, Haack H, Crowley D, Barry M, Bronson RT, Hynes RO. Tumor-secreted vascular endothelial growth factor-C is necessary for prostate cancer lymphangiogenesis, but lymphangiogenesis is unnecessary for lymph node metastasis. Cancer Research. 65: 9789-98. PMID 16267000 DOI: 10.1158/0008-5472.CAN-05-0901  1
2005 McCarty JH, Cook AA, Hynes RO. An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain. Proceedings of the National Academy of Sciences of the United States of America. 102: 13479-83. PMID 16157875 DOI: 10.1073/pnas.0506068102  1
2005 Moreno JD, Hynes RO. Guidelines for human embryonic stem cell research. Nature Biotechnology. 23: 793-4. PMID 16003357 DOI: 10.1038/nbt0705-793  1
2005 Fang J, Hodivala-Dilke K, Johnson BD, Du LM, Hynes RO, White GC, Wilcox DA. Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia. Blood. 106: 2671-9. PMID 15972454 DOI: 10.1182/blood-2004-12-4619  1
2005 Lindenbach BD, Evans MJ, Syder AJ, Wölk B, Tellinghuisen TL, Liu CC, Maruyama T, Hynes RO, Burton DR, McKeating JA, Rice CM. Complete replication of hepatitis C virus in cell culture. Science (New York, N.Y.). 309: 623-6. PMID 15947137 DOI: 10.1126/science.1114016  1
2005 Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO. Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. Experimental Cell Research. 308: 177-87. PMID 15913605 DOI: 10.1016/j.yexcr.2005.04.017  1
2005 Reynolds LE, Conti FJ, Lucas M, Grose R, Robinson S, Stone M, Saunders G, Dickson C, Hynes RO, Lacy-Hulbert A, Hodivala-Dilke K. Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Nature Medicine. 11: 167-74. PMID 15654327 DOI: 10.1038/nm1165  1
2005 McCarty JH, Lacy-Hulbert A, Charest A, Bronson RT, Crowley D, Housman D, Savill J, Roes J, Hynes RO. Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development (Cambridge, England). 132: 165-76. PMID 15576410 DOI: 10.1242/dev.01551  1
2004 Singh P, Reimer CL, Peters JH, Stepp MA, Hynes RO, Van De Water L. The spatial and temporal expression patterns of integrin alpha9beta1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. The Journal of Investigative Dermatology. 123: 1176-81. PMID 15610531 DOI: 10.1111/j.0022-202X.2004.23485.x  1
2004 Hynes RO. The emergence of integrins: a personal and historical perspective. Matrix Biology : Journal of the International Society For Matrix Biology. 23: 333-40. PMID 15533754 DOI: 10.1016/j.matbio.2004.08.001  1
2004 Astrof S, Crowley D, George EL, Fukuda T, Sekiguchi K, Hanahan D, Hynes RO. Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis. Molecular and Cellular Biology. 24: 8662-70. PMID 15367684 DOI: 10.1128/MCB.24.19.8662-8670.2004  1
2004 Hobert O, Hutter H, Hynes RO. The immunoglobulin superfamily in Caenorhabditis elegans and Drosophila melanogaster. Development (Cambridge, England). 131: 2237-8; author reply. PMID 15128663 DOI: 10.1242/dev.01183  1
2004 Taverna D, Moher H, Crowley D, Borsig L, Varki A, Hynes RO. Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins. Proceedings of the National Academy of Sciences of the United States of America. 101: 763-8. PMID 14718670 DOI: 10.1073/pnas.0307289101  1
2003 Alugupalli KR, Michelson AD, Joris I, Schwan TG, Hodivala-Dilke K, Hynes RO, Leong JM. Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis. Blood. 102: 2843-50. PMID 12855586 DOI: 10.1182/blood-2003-02-0426  1
2003 Hamano Y, Zeisberg M, Sugimoto H, Lively JC, Maeshima Y, Yang C, Hynes RO, Werb Z, Sudhakar A, Kalluri R. Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell. 3: 589-601. PMID 12842087 DOI: 10.1016/S1535-6108(03)00133-8  1
2003 Hynes RO. Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both? Cell. 113: 821-3. PMID 12837240 DOI: 10.1016/S0092-8674(03)00468-9  1
2003 Peters JH, Loredo GA, Chen G, Maunder R, Hahn TJ, Willits NH, Hynes RO. Plasma levels of fibronectin bearing the alternatively spliced EIIIB segment are increased after major trauma. The Journal of Laboratory and Clinical Medicine. 141: 401-10. PMID 12819638 DOI: 10.1016/S0022-2143(03)00042-8  1
2003 Hynes RO. Structural biology. Changing partners. Science (New York, N.Y.). 300: 755-6. PMID 12730590 DOI: 10.1126/science.1084854  1
2003 Ni H, Yuen PS, Papalia JM, Trevithick JE, Sakai T, Fässler R, Hynes RO, Wagner DD. Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proceedings of the National Academy of Sciences of the United States of America. 100: 2415-9. PMID 12606706 DOI: 10.1073/pnas.2628067100  1
2002 Hynes RO, Lively JC, McCarty JH, Taverna D, Francis SE, Hodivala-Dilke K, Xiao Q. The diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harbor Symposia On Quantitative Biology. 67: 143-53. PMID 12858535  1
2002 Whittaker CA, Hynes RO. Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. Molecular Biology of the Cell. 13: 3369-87. PMID 12388743 DOI: 10.1091/mbc.E02-05-0259  1
2002 McCarty JH, Monahan-Earley RA, Brown LF, Keller M, Gerhardt H, Rubin K, Shani M, Dvorak HF, Wolburg H, Bader BL, Dvorak AM, Hynes RO. Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Molecular and Cellular Biology. 22: 7667-77. PMID 12370313 DOI: 10.1128/MCB.22.21.7667-7677.2002  1
2002 Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 110: 673-87. PMID 12297042 DOI: 10.1016/S0092-8674(02)00971-6  1
2002 Hynes RO. A reevaluation of integrins as regulators of angiogenesis. Nature Medicine. 8: 918-21. PMID 12205444 DOI: 10.1038/nm0902-918  1
2002 Francis SE, Goh KL, Hodivala-Dilke K, Bader BL, Stark M, Davidson D, Hynes RO. Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 927-33. PMID 12067900 DOI: 10.1161/01.ATV.0000016045.93313.F2  1
2002 Zhu GZ, Miller BJ, Boucheix C, Rubinstein E, Liu CC, Hynes RO, Myles DG, Primakoff P. Residues SFQ (173-175) in the large extracellular loop of CD9 are required for gamete fusion. Development (Cambridge, England). 129: 1995-2002. PMID 11934865  1
2002 André P, Prasad KS, Denis CV, He M, Papalia JM, Hynes RO, Phillips DR, Wagner DD. CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism. Nature Medicine. 8: 247-52. PMID 11875495 DOI: 10.1038/nm0302-247  1
2002 Borsig L, Wong R, Hynes RO, Varki NM, Varki A. Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proceedings of the National Academy of Sciences of the United States of America. 99: 2193-8. PMID 11854515 DOI: 10.1073/pnas.261704098  1
2002 Alcamo E, Hacohen N, Schulte LC, Rennert PD, Hynes RO, Baltimore D. Requirement for the NF-kappaB family member RelA in the development of secondary lymphoid organs. The Journal of Experimental Medicine. 195: 233-44. PMID 11805150 DOI: 10.1084/jem.20011885  1
2002 Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nature Medicine. 8: 27-34. PMID 11786903 DOI: 10.1038/nm0102-27  1
2002 Maeshima Y, Sudhakar A, Lively JC, Ueki K, Kharbanda S, Kahn CR, Sonenberg N, Hynes RO, Kalluri R. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (New York, N.Y.). 295: 140-3. PMID 11778052 DOI: 10.1126/science.1065298  1
2001 Lawler J, Miao WM, Duquette M, Bouck N, Bronson RT, Hynes RO. Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. The American Journal of Pathology. 159: 1949-56. PMID 11696456 DOI: 10.1016/S0002-9440(10)63042-8  1
2001 Rodriguez-Manzaneque JC, Lane TF, Ortega MA, Hynes RO, Lawler J, Iruela-Arispe ML. Thrombospondin-1 suppresses spontaneous tumor growth and inhibits activation of matrix metalloproteinase-9 and mobilization of vascular endothelial growth factor. Proceedings of the National Academy of Sciences of the United States of America. 98: 12485-90. PMID 11606713 DOI: 10.1073/pnas.171460498  1
2001 Alcamo E, Mizgerd JP, Horwitz BH, Bronson R, Beg AA, Scott M, Doerschuk CM, Hynes RO, Baltimore D. Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. Journal of Immunology (Baltimore, Md. : 1950). 167: 1592-600. PMID 11466381  1
2001 DiPersio CM, Trevithick JE, Hynes RO. Functional comparison of the alpha3A and alpha3B cytoplasmic domain variants of the chicken alpha3 integrin subunit. Experimental Cell Research. 268: 45-60. PMID 11461117 DOI: 10.1006/excr.2001.5273  1
2001 Taverna D, Hynes RO. Reduced blood vessel formation and tumor growth in alpha5-integrin-negative teratocarcinomas and embryoid bodies. Cancer Research. 61: 5255-61. PMID 11431367  1
2001 Niederman R, Westernoff T, Lee C, Mark LL, Kawashima N, Ullman-Culler M, Dewhirst FE, Paster BJ, Wagner DD, Mayadas T, Hynes RO, Stashenko P. Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice. Journal of Clinical Periodontology. 28: 569-75. PMID 11350525  1
2001 Haack H, Hynes RO. Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage. Developmental Biology. 233: 38-55. PMID 11319856 DOI: 10.1006/dbio.2001.0213  1
2001 Bono P, Rubin K, Higgins JM, Hynes RO. Layilin, a novel integral membrane protein, is a hyaluronan receptor. Molecular Biology of the Cell. 12: 891-900. PMID 11294894  1
2001 Wheeler GN, Hynes RO. The cloning, genomic organization and expression of the focal contact protein paxillin in Drosophila. Gene. 262: 291-9. PMID 11179695 DOI: 10.1016/S0378-1119(00)00512-6  1
2000 André P, Denis CV, Ware J, Saffaripour S, Hynes RO, Ruggeri ZM, Wagner DD. Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins. Blood. 96: 3322-8. PMID 11071623  1
2000 Arroyo AG, Taverna D, Whittaker CA, Strauch UG, Bader BL, Rayburn H, Crowley D, Parker CM, Hynes RO. In vivo roles of integrins during leukocyte development and traffic: insights from the analysis of mice chimeric for alpha 5, alpha v, and alpha 4 integrins. Journal of Immunology (Baltimore, Md. : 1950). 165: 4667-75. PMID 11035110 DOI: 10.4049/jimmunol.165.8.4667  1
2000 Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature. 406: 532-5. PMID 10952316 DOI: 10.1038/35020106  1
2000 DiPersio CM, van der Neut R, Georges-Labouesse E, Kreidberg JA, Sonnenberg A, Hynes RO. alpha3beta1 and alpha6beta4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development. Journal of Cell Science. 113: Pt 17/-. PMID 10934043  1
2000 Ni H, Denis CV, Subbarao S, Degen JL, Sato TN, Hynes RO, Wagner DD. Persistence of platelet thrombus formation in arterioles of mice lacking both von Willebrand factor and fibrinogen. The Journal of Clinical Investigation. 106: 385-92. PMID 10930441 DOI: 10.1172/JCI9896  1
2000 DiPersio CM, Shao M, Di Costanzo L, Kreidberg JA, Hynes RO. Mouse keratinocytes immortalized with large T antigen acquire α3β1 integrin-dependent secretion of MMP-9/gelatinase B Journal of Cell Science. 113: 2909-2921. PMID 10910775  1
2000 Hynes RO, Zhao Q. The evolution of cell adhesion Journal of Cell Biology. 150: F89-F95. PMID 10908592  1
2000 Rubin GM, Yandell MD, Wortman JR, Gabor Miklos GL, Nelson CR, Hariharan IK, Fortini ME, Li PW, Apweiler R, Fleischmann W, Cherry JM, Henikoff S, Skupski MP, Misra S, Ashburner M, ... ... Hynes RO, et al. Comparative genomics of the eukaryotes. Science (New York, N.Y.). 287: 2204-15. PMID 10731134 DOI: 10.1126/science.287.5461.2204  1
2000 McHugh KP, Hodivala-Dilke K, Zheng MH, Namba N, Jonathan L, Novack D, Feng X, Ross FP, Hynes RO, Teitelbaum SL. Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts Journal of Clinical Investigation. 105: 433-440. PMID 10683372  1
2000 DiPersio CM, van der Neut R, Georges-Labouesse E, Kreidberg JA, Sonnenberg A, Hynes RO. α3β1 and ↑β4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development Journal of Cell Science. 113: 3051-3062.  1
1999 Hynes RO. Cell adhesion: Old and new questions Trends in Cell Biology. 9: M33-M37. PMID 10611678 DOI: 10.1016/S0962-8924(99)01667-0  1
1999 Fox GL, Rebay I, Hynes RO. Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 96: 14978-83. PMID 10611323 DOI: 10.1073/pnas.96.26.14978  1
1999 Hynes RO, Hodivala-Dilke KM. Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia Thrombosis and Haemostasis. 82: 481-485. PMID 10605739  1
1999 Arroyo AG, Yang JT, Rayburn H, Hynes RO. α4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo Immunity. 11: 555-566. PMID 10591181  1
1999 Yang JT, Bader BL, Kreidberg JA, Ullman-Culleré M, Trevithick JE, Hynes RO. Overlapping and independent functions of fibronectin receptor integrins in early mesodermal development Developmental Biology. 215: 264-277. PMID 10545236 DOI: 10.1006/dbio.1999.9451  1
1999 Lyden D, Young AZ, Zagzag D, Yan W, Gerald W, O'Reilly R, Bader BL, Hynes RO, Zhuang Y, Manova K, Benezra R. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature. 401: 670-7. PMID 10537105 DOI: 10.1038/44334  1
1999 Robinson SD, Frenette PS, Rayburn H, Cummiskey M, Ullman-Culleré M, Wagner DD, Hynes RO. Multiple, targeted deficiencies in selectins reveal a predominant role for P-selectin in leukocyte recruitment. Proceedings of the National Academy of Sciences of the United States of America. 96: 11452-7. PMID 10500197 DOI: 10.1073/pnas.96.20.11452  1
1999 Calderwood DA, Zent R, Grant R, Rees DJG, Hynes RO, Ginsberg MH. The talin head domain binds to integrin β subunit cytoplasmic tails and regulates integrin activation Journal of Biological Chemistry. 274: 28071-28074. PMID 10497155 DOI: 10.1074/jbc.274.40.28071  1
1999 Kawashima N, Niederman R, Hynes RO, Ullmann-Cullere M, Stashenko P. Infection-stimulated infraosseus inflammation and bone destruction is increased in P-/E-selectin knockout mice Immunology. 97: 117-123. PMID 10447722 DOI: 10.1046/j.1365-2567.1999.00754.x  1
1999 Hynes RO, Bader BL, Hodivala-Dilke K. Integrins in vascular development Brazilian Journal of Medical and Biological Research. 32: 501-510. PMID 10412560  1
1999 Bloom L, Ingham KC, Hynes RO. Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13. Molecular Biology of the Cell. 10: 1521-36. PMID 10233160  1
1999 Anderson R, Fässler R, Georges-Labouesse E, Hynes RO, Bader BL, Kreidberg JA, Schaible K, Heasman J, Wylie C. Mouse primordial germ cells lacking β1 integrins enter the germline but fail to migrate normally to the gonads Development. 126: 1655-1664. PMID 10079228  1
1999 Saoncella S, Echtermeyer F, Denhez F, Nowlen JK, Mosher DF, Robinson SD, Hynes RO, Goetinck PF. Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers. Proceedings of the National Academy of Sciences of the United States of America. 96: 2805-10. PMID 10077592 DOI: 10.1073/pnas.96.6.2805  1
1999 Hynes RO. The dynamic dialogue between cells and matrices: Implications of fibronectin's elasticity Proceedings of the National Academy of Sciences of the United States of America. 96: 2588-2590. PMID 10077553 DOI: 10.1073/pnas.96.6.2588  1
1999 Tsakiris DA, Scudder L, Hodivala-Dilke K, Hynes RO, Coller BS. Hemostasis in the mouse (Mus musculus): A review Thrombosis and Haemostasis. 81: 177-188. PMID 10063988  1
1999 Robert C, Fuhlbrigge RC, Kieffer JD, Ayehunie S, Hynes RO, Cheng G, Grabbe S, Von Andrian UH, Kupper TS. Interaction of dendritic cells with skin endothelium: A new perspective on immunosurveillance Journal of Experimental Medicine. 189: 627-635. PMID 9989977 DOI: 10.1084/jem.189.4.627  1
1999 Hodivala-Dilke KM, McHugh KP, Tsakiris DA, Rayburn H, Crowley D, Ullman-Culleré M, Ross FP, Coller BS, Teitelbaum S, Hynes RO. β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival Journal of Clinical Investigation. 103: 229-238. PMID 9916135  1
1998 Bader BL, Rayburn H, Crowley D, Hynes RO. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins Cell. 95: 507-519. PMID 9827803  1
1998 Hartwell DW, Mayadas TN, Berger G, Frenette PS, Rayburn H, Hynes RO, Wagner DD. Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses. The Journal of Cell Biology. 143: 1129-41. PMID 9817767 DOI: 10.1083/jcb.143.4.1129  1
1998 Taverna D, Disatnik MH, Rayburn H, Bronson RT, Yang J, Rando TA, Hynes RO. Dystrophic muscle in mice chimeric for expression of α5 integrin Journal of Cell Biology. 143: 849-859. PMID 9813102 DOI: 10.1083/jcb.143.3.849  1
1998 Hartwell DW, Butterfield CE, Frenette PS, Kenyon BM, Hynes RO, Folkman J, Wagner DD. Angiogenesis in P- and E-selectin-deficient mice. Microcirculation (New York, N.Y. : 1994). 5: 173-8. PMID 9789257  1
1998 Borowsky ML, Hynes RO. Layilin, a novel talin-binding transmembrane protein homologous with C- type lectins, is localized in membrane ruffles Journal of Cell Biology. 143: 429-442. PMID 9786953 DOI: 10.1083/jcb.143.2.429  1
1998 Homeister JW, Zhang M, Frenette PS, Hynes RO, Wagner DD, Lowe JB, Marks RM. Overlapping functions of E- and P-selectin in neutrophil recruitment during acute inflammation. Blood. 92: 2345-52. PMID 9746773  1
1998 Hodivala-Dilke KM, DiPersio CM, Kreidberg JA, Hynes RO. Novel roles for α3β1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes Journal of Cell Biology. 142: 1357-1369. PMID 9732295 DOI: 10.1083/jcb.142.5.1357  1
1998 Seiler KP, Ma Y, Weis JH, Frenette PS, Hynes RO, Wagner DD, Weis JJ. E and P selectins are not required for resistance to severe murine lyme arthritis. Infection and Immunity. 66: 4557-9. PMID 9712820  1
1998 Denis C, Methia N, Frenette PS, Rayburn H, Ullman-Culleré M, Hynes RO, Wagner DD. A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proceedings of the National Academy of Sciences of the United States of America. 95: 9524-9. PMID 9689113 DOI: 10.1073/pnas.95.16.9524  1
1998 Mazo IB, Gutierrez-Ramos JC, Frenette PS, Hynes RO, Wagner DD, von Andrian UH. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. The Journal of Experimental Medicine. 188: 465-74. PMID 9687524 DOI: 10.1084/jem.188.3.465  1
1998 Clark EA, King WG, Brugge JS, Symons M, Hynes RO. Integrin-mediated signals regulated by members of the rho family of gtpases Journal of Cell Biology. 142: 573-586. PMID 9679153 DOI: 10.1083/jcb.142.2.573  1
1998 Crawford SE, Stellmach V, Murphy-Ullrich JE, Ribeiro SMF, Lawler J, Hynes RO, Boivin GP, Bouck N. Thrombospondin-1 is a major activator of TGF-β1 in vivo Cell. 93: 1159-1170. PMID 9657149 DOI: 10.1016/S0092-8674(00)81460-9  1
1998 Dong ZM, Chapman SM, Brown AA, Frenette PS, Hynes RO, Wagner DD. The combined role of P- and E-selectins in atherosclerosis. The Journal of Clinical Investigation. 102: 145-52. PMID 9649568 DOI: 10.1172/JCI3001  1
1998 de Mora F, Williams CM, Frenette PS, Wagner DD, Hynes RO, Galli SJ. P- and E-selectins are required for the leukocyte recruitment, but not the tissue swelling, associated with IgE- and mast cell-dependent inflammation in mouse skin. Laboratory Investigation; a Journal of Technical Methods and Pathology. 78: 497-505. PMID 9564894  1
1998 Lawler J, Sunday M, Thibert V, Duquette M, George EL, Rayburn H, Hynes RO. Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia Journal of Clinical Investigation. 101: 982-992. PMID 9486968  1
1998 Taverna D, Ullman-Culleré M, Rayburn H, Bronson RT, Hynes RO. A test of the role of α5 integrin/fibronectin interactions in tumorigenesis Cancer Research. 58: 848-853. PMID 9485045  1
1998 Frenette PS, Moyna C, Hartwell DW, Lowe JB, Hynes RO, Wagner DD. Platelet-endothelial interactions in inflamed mesenteric venules. Blood. 91: 1318-24. PMID 9454762  1
1997 Clark EA, Hynes RO. 1997 keystone symposium on signal transduction by cell adhesion receptors Biochimica Et Biophysica Acta - Reviews On Cancer. 1333: R9-R16. PMID 9426206 DOI: 10.1016/S0304-419X(97)00028-0  1
1997 Hynes RO, Wagner DD. Genetic manipulation of vascular adhesion molecules in mice. The Journal of Clinical Investigation. 100: S11-3. PMID 9413394  1
1997 Stark KA, Yee GH, Roote CE, Williams EL, Zusman S, Hynes RO. A novel alpha integrin subunit associates with betaPS and functions in tissue morphogenesis and movement during Drosophila development. Development (Cambridge, England). 124: 4583-94. PMID 9409675  1
1997 George EL, Baldwin HS, Hynes RO. Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells Blood. 90: 3073-3081. PMID 9376588  1
1997 Radice GL, Ferreira-Cornwell MC, Robinson SD, Rayburn H, Chodosh LA, Takeichi M, Hynes RO. Precocious mammary gland development in P-cadherin-deficient mice. The Journal of Cell Biology. 139: 1025-32. PMID 9362520 DOI: 10.1083/jcb.139.4.1025  1
1997 Hedjran F, Yeakley JM, Huh GS, Hynes RO, Rosenfeld MG. Control of alternative pre-mRNA splicing by distributed pentameric repeats. Proceedings of the National Academy of Sciences of the United States of America. 94: 12343-7. PMID 9356451 DOI: 10.1073/pnas.94.23.12343  1
1997 Goh KL, Yang JT, Hynes RO. Mesodermal defects and cranial neural crest apoptosis in α5 integrin-null embryos Development. 124: 4309-4319. PMID 9334279  1
1997 Walter UM, Ayer LM, Manning AM, Frenette PS, Wagner DD, Hynes RO, Wolitzky BA, Issekutz AC. Generation and characterization of a novel adhesion function blocking monoclonal antibody recognizing both rat and mouse E-selectin. Hybridoma. 16: 355-61. PMID 9309426  1
1997 Charlton CA, Mohler WA, Radice GL, Hynes RO, Blau HM. Fusion competence of myoblasts rendered genetically null for N-cadherin in culture Journal of Cell Biology. 138: 331-336. PMID 9230075 DOI: 10.1083/jcb.138.2.331  1
1997 Walter UM, Ayer LM, Wolitzky BA, Wagner DD, Hynes RO, Manning AM, Issekutz AC. Characterization of a novel adhesion function blocking monoclonal antibody to rat/mouse P-selectin generated in the P-selectin-deficient mouse. Hybridoma. 16: 249-57. PMID 9219035  1
1997 Hynes RO, Bader BL. Targeted mutations in integrins and their ligands: Their implications for vascular biology Thrombosis and Haemostasis. 78: 83-87. PMID 9198133  1
1997 DiPersio CM, Hodivala-Dilke KM, Jaenisch R, Kreidberg JA, Hynes RO. alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. The Journal of Cell Biology. 137: 729-42. PMID 9151677 DOI: 10.1083/jcb.137.3.729  1
1997 Johnson RC, Chapman SM, Dong ZM, Ordovas JM, Mayadas TN, Herz J, Hynes RO, Schaefer EJ, Wagner DD. Absence of P-selectin delays fatty streak formation in mice. The Journal of Clinical Investigation. 99: 1037-43. PMID 9062362 DOI: 10.1172/JCI119231  1
1997 Radice GL, Rayburn H, Matsunami H, Knudsen KA, Takeichi M, Hynes RO. Developmental defects in mouse embryos lacking N-cadherin. Developmental Biology. 181: 64-78. PMID 9015265 DOI: 10.1006/dbio.1996.8443  1
1997 Hynes RO. Genetic dissection of integrin functions Faseb Journal. 11: A865.  1
1997 Subramaniam M, Saffaripour S, Van De Water L, Frenette PS, Mayadas TN, Hynes RO, Wagner DD. Role of endothelial selectins in wound repair American Journal of Pathology. 150: 1701-1709.  1
1996 Stellmach V, Volpert OV, Crawford SE, Lawler J, Hynes RO, Bouck N. Tumour suppressor genes and angiogenesis: The role of TP53 in fibroblasts European Journal of Cancer Part A. 32: 2394-2400. PMID 9059327 DOI: 10.1016/S0959-8049(96)00385-1  1
1996 Frenette PS, Mayadas TN, Rayburn H, Hynes RO, Wagner DD. Double knockout highlights value of endothelial selectins. Immunology Today. 17: 205. PMID 8991376  1
1996 Hynes RO. Targeted mutations in cell adhesion genes: What have we learned from them? Developmental Biology. 180: 402-412. PMID 8954713 DOI: 10.1006/dbio.1996.0314  1
1996 Hynes RO, Wagner DD. Genetic manipulation of vascular adhesion molecules in mice. The Journal of Clinical Investigation. 98: 2193-5. PMID 8941633 DOI: 10.1172/JCI119027  1
1996 Hemmings L, Rees DJG, Ohanian V, Bolton SJ, Gilmore AP, Patel B, Priddle H, Trevithick JE, Hynes RO, Critchley DR. Talin contains three actin-binding sites each of which is adjacent to a vinculin-binding site Journal of Cell Science. 109: 2715-2726. PMID 8937989  1
1996 Peters JH, Chen GE, Hynes RO. Fibronectin isoform distribution in the mouse. II. Differential distribution of the alternatively spliced EIIIB, EIIIA, and V segments in the adult mouse. Cell Adhesion and Communication. 4: 127-48. PMID 8937747  1
1996 Peters JH, Hynes RO. Fibronectin isoform distribution in the mouse. I. The alternatively spliced EIIIB, EIIIA, and V segments show widespread codistribution in the developing mouse embryo. Cell Adhesion and Communication. 4: 103-25. PMID 8937746  1
1996 Yang JT, Hynes RO. Fibronectin receptor functions in embryonic cells deficient in α5β1 integrin can be replaced by α(v) integrins Molecular Biology of the Cell. 7: 1737-1748. PMID 8930896 DOI: 10.1091/mbc.7.11.1737  1
1996 Yang JT, Rando TA, Mohler WA, Rayburn H, Blau HM, Hynes RO. Genetic analysis of α4 integrin functions in the development of mouse skeletal muscle Journal of Cell Biology. 135: 829-835. PMID 8909554 DOI: 10.1083/jcb.135.3.829  1
1996 Georges-Labouesse EN, George EL, Rayburn H, Hynes RO. Mesodermal development in mouse embryos mutant for fibronectin Developmental Dynamics. 207: 145-156. PMID 8906418 DOI: 10.1002/(SICI)1097-0177(199610)207:2<145::AID-AJA3>3.0.CO;2-H  1
1996 Mayadas TN, Mendrick DL, Brady HR, Tang T, Papayianni A, Assmann KJ, Wagner DD, Hynes RO, Cotran RS. Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice. Kidney International. 49: 1342-9. PMID 8731099  1
1996 Arroyo AG, Yang JT, Rayburn H, Hynes RO. Differential requirements for α4 integrins during fetal and adult hematopoiesis Cell. 85: 997-1008. PMID 8674127 DOI: 10.1016/S0092-8674(00)81301-X  1
1996 Clark EA, Hynes RO. Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A 2 but not for cytoskeletal organization Journal of Biological Chemistry. 271: 14814-14818. PMID 8663348 DOI: 10.1074/jbc.271.25.14814  1
1996 Tang T, Frenette PS, Hynes RO, Wagner DD, Mayadas TN. Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. The Journal of Clinical Investigation. 97: 2485-90. PMID 8647940 DOI: 10.1172/JCI118695  1
1996 Subramaniam M, Frenette PS, Saffaripour S, Johnson RC, Hynes RO, Wagner DD. Defects in hemostasis in P-selectin-deficient mice. Blood. 87: 1238-42. PMID 8608210  1
1996 Frenette PS, Mayadas TN, Rayburn H, Hynes RO, Wagner DD. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell. 84: 563-74. PMID 8598043 DOI: 10.1016/S0092-8674(00)81032-6  1
1996 Pinsky DJ, Naka Y, Liao H, Oz MC, Wagner DD, Mayadas TN, Johnson RC, Hynes RO, Heath M, Lawson CA, Stern DM. Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. The Journal of Clinical Investigation. 97: 493-500. PMID 8567972 DOI: 10.1172/JCI118440  1
1995 Zhang S, Holmes TC, DiPersio CM, Hynes RO, Su X, Rich A. Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials. 16: 1385-93. PMID 8590765 DOI: 10.1016/0142-9612(95)96874-Y  1
1995 George EL, Hynes RO. Gene targeting and generation of mutant mice for studies of cell-extracellular matrix interactions Methods in Enzymology. 245: 386-420. PMID 7760744 DOI: 10.1016/0076-6879(94)45021-8  1
1995 Hynes RO. Cell adhesion and human disease. Chairman's introduction Ciba Foundation Symposium. 189: 1. PMID 7587626  1
1995 Yamada S, Mayadas TN, Yuan F, Wagner DD, Hynes RO, Melder RJ, Jain RK. Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin. Blood. 86: 3487-92. PMID 7579454  1
1995 Nickeleit V, Zagachin L, Nishikawa K, Peters JH, Hynes RO, Colvin RB. Embryonic fibronectin isoforms are synthesized in crescents in experimental autoimmune glomerulonephritis American Journal of Pathology. 147: 965-978. PMID 7573372  1
1995 Frenette PS, Johnson RC, Hynes RO, Wagner DD. Platelets roll on stimulated endothelium in vivo: an interaction mediated by endothelial P-selectin. Proceedings of the National Academy of Sciences of the United States of America. 92: 7450-4. PMID 7543682 DOI: 10.1073/pnas.92.16.7450  1
1995 Yang JT, Rayburn H, Hynes RO. Cell adhesion events mediated by α4 integrins are essential in placental and cardiac development Development. 121: 549-560. PMID 7539359  1
1995 Subramaniam M, Saffaripour S, Watson SR, Mayadas TN, Hynes RO, Wagner DD. Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice. The Journal of Experimental Medicine. 181: 2277-82. PMID 7539046 DOI: 10.1084/jem.181.6.2277  1
1995 Peters JH, Trevithick JE, Johnson P, Hynes RO. Expression of the alternatively spliced EIIIB segment of fibronectin Cell Communication and Adhesion. 3: 67-89. PMID 7538416 DOI: 10.3109/15419069509081278  1
1994 Spring J, Paine-Saunders SE, Hynes RO, Bernfield M. Drosophila syndecan: Conservation of a cell-surface heparan sulfate proteoglycan Proceedings of the National Academy of Sciences of the United States of America. 91: 3334-3338. PMID 8159748 DOI: 10.1073/pnas.91.8.3334  1
1994 Gotwals PJ, Fessler LI, Wehrli M, Hynes RO. Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2. Proceedings of the National Academy of Sciences of the United States of America. 91: 11447-51. PMID 7972082 DOI: 10.1073/pnas.91.24.11447  1
1994 Huh GS, Hynes RO. Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes & Development. 8: 1561-74. PMID 7958840 DOI: 10.1101/gad.8.13.1561  1
1994 Gotwals PJ, Paine-Saunders SE, Stark KA, Hynes RO. Drosophila integrins and their ligands Current Opinion in Cell Biology. 6: 734-739. PMID 7833052 DOI: 10.1016/0955-0674(94)90101-5  1
1994 Stepp MA, Urry LA, Hynes RO. Expression of α4 integrin mRNA and protein and fibronectin in the early chicken embryo Cell Communication and Adhesion. 2: 359-375. DOI: 10.3109/15419069409014210  1
1993 Huh GS, Hynes RO. Elements regulating an alternatively spliced exon of the rat fibronectin gene. Molecular and Cellular Biology. 13: 5301-14. PMID 8355683 DOI: 10.1128/MCB.13.9.5301  1
1993 Mayadas TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell. 74: 541-54. PMID 7688665 DOI: 10.1016/0092-8674(93)80055-J  0.32
1992 Hynes RO, Lander AD. Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell. 68: 303-22. PMID 1733501 DOI: 10.1016/0092-8674(92)90472-O  1
1992 DeSimone DW, Norton PA, Hynes RO. Identification and characterization of alternatively spliced fibronectin mRNAs expressed in early Xenopus embryos Developmental Biology. 149: 357-369. PMID 1730390 DOI: 10.1016/0012-1606(92)90291-N  1
1992 Hynes RO, George EL, Georges EN, Guan JL, Rayburn H, Yang JT. Toward a genetic analysis of cell-matrix adhesion. Cold Spring Harbor Symposia On Quantitative Biology. 57: 249-58. PMID 1339663 DOI: 10.1101/SQB.1992.057.01.030  0.92
1991 Guan JL, Trevithick JE, Hynes RO. Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regulation. 2: 951-64. PMID 1725602 DOI: 10.1091/mbc.2.11.951  0.92
1990 Guan JL, Trevithick JE, Hynes RO. Retroviral expression of alternatively spliced forms of rat fibronectin. The Journal of Cell Biology. 110: 833-47. PMID 2307710 DOI: 10.1083/jcb.110.3.833  0.92
1990 Guan JL, Hynes RO. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell. 60: 53-61. PMID 2295088 DOI: 10.1016/0092-8674(90)90715-Q  0.92
1990 Rees DJG, Ades SE, Singer SJ, Hynes RO. Sequence and domain structure of talin Nature. 347: 685-689. PMID 2120593 DOI: 10.1038/347685a0  1
1990 Marcantonio EE, Guan JL, Trevithick JE, Hynes RO. Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis. Cell Regulation. 1: 597-604. PMID 2078570  1
1989 Solowska J, Guan JL, Marcantonio EE, Trevithick JE, Buck CA, Hynes RO. Expression of normal and mutant avian integrin subunits in rodent cells. The Journal of Cell Biology. 109: 853-61. PMID 2788168 DOI: 10.1083/jcb.109.2.853  1
1989 Ffrench-Constant C, Van de Water L, Dvorak HF, Hynes RO. Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat. The Journal of Cell Biology. 109: 903-14. PMID 2760116 DOI: 10.1083/jcb.109.2.903  1
1989 Hynes RO, Marcantonio EE, Stepp MA, Urry LA, Yee GH. Integrin heterodimer and receptor complexity in avian and mammalian cells. The Journal of Cell Biology. 109: 409-20. PMID 2663881  1
1988 Marcantonio EE, Hynes RO. Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi. The Journal of Cell Biology. 106: 1765-72. PMID 3131349  1
1987 Lawler J, Hynes RO. Structural organization of the thrombospondin molecule Seminars in Thrombosis and Hemostasis. 13: 245-254. PMID 3686017 DOI: 10.1055/s-2007-1003499  1
1987 Patel RS, Odermatt E, Schwarzbauer JE, Hynes RO. Organization of the fibronectin gene provides evidence for exon shuffling during evolution. The Embo Journal. 6: 2565-72. PMID 3119323  0.68
1987 Schwarzbauer JE, Mulligan RC, Hynes RO. Efficient and stable expression of recombinant fibronectin polypeptides. Proceedings of the National Academy of Sciences of the United States of America. 84: 754-8. PMID 3027700  0.68
1987 Hynes RO, Schwarzbauer JE, Tamkun JW. Isolation and analysis of cDNA and genomic clones of fibronectin and its receptor. Methods in Enzymology. 144: 447-63. PMID 2957568 DOI: 10.1016/0076-6879(87)44194-3  1
1987 DeSimone DW, Stepp MA, Patel RS, Hynes RO. The integrin family of cell surface receptors Biochemical Society Transactions. 15: 789-791. PMID 2826269 DOI: 10.1042/bst0150789a  1
1987 Schwarzbauer JE, Patel RS, Fonda D, Hynes RO. Multiple sites of alternative splicing of the rat fibronectin gene transcript. The Embo Journal. 6: 2573-80. PMID 2445560  0.68
1986 Paul JI, Schwarzbauer JE, Tamkun JW, Hynes RO. Cell-type-specific fibronectin subunits generated by alternative splicing. The Journal of Biological Chemistry. 261: 12258-65. PMID 3528152  1
1986 Tamkun JW, DeSimone DW, Fonda D, Patel RS, Buck C, Horwitz AF, Hynes RO. Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell. 46: 271-82. PMID 3487386 DOI: 10.1016/0092-8674(86)90744-0  0.64
1986 Lawler J, Hynes RO. The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins Journal of Cell Biology. 103: 1635-1648. PMID 2430973 DOI: 10.1083/jcb.103.5.1635  1
1985 Odermatt E, Tamkun JW, Hynes RO. Repeating modular structure of the fibronectin gene: relationship to protein structure and subunit variation. Proceedings of the National Academy of Sciences of the United States of America. 82: 6571-5. PMID 3863113 DOI: 10.1073/pnas.82.19.6571  1
1985 Schwarzbauer JE, Paul JI, Hynes RO. On the origin of species of fibronectin. Proceedings of the National Academy of Sciences of the United States of America. 82: 1424-8. PMID 3856272  0.68
1985 Gardner JM, Hynes RO. Interaction of fibronectin with its receptor on platelets Cell. 42: 439-448. PMID 2411420 DOI: 10.1016/0092-8674(85)90101-1  1
1984 Hynes RO, Schwarzbauer JE, Tamkun JW. Fibronectin: a versatile gene for a versatile protein. Ciba Foundation Symposium. 108: 75-92. PMID 6569832  1
1984 Tamkun JW, Schwarzbauer JE, Hynes RO. A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon. Proceedings of the National Academy of Sciences of the United States of America. 81: 5140-4. PMID 6089177  1
1983 Senger DR, Destree AT, Hynes RO. Complex regulation of fibronectin synthesis by cells in culture. The American Journal of Physiology. 245: C144-50. PMID 6869518  1
1983 Schwarzbauer JE, Tamkun JW, Lemischka IR, Hynes RO. Three different fibronectin mRNAs arise by alternative splicing within the coding region. Cell. 35: 421-31. PMID 6317187 DOI: 10.1016/0092-8674(83)90175-7  1
1982 Lahav J, Schwartz MA, Hynes RO. Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell. 31: 253-62. PMID 7159924  0.44
1982 Schwartz MA, Das OP, Hynes RO. A new radioactive cross-linking reagent for studying the interactions of proteins. The Journal of Biological Chemistry. 257: 2343-9. PMID 7061425  1
1982 Hynes RO, Destree AT, Wagner DD. Relationships between microfilaments, cell-substratum adhesion, and fibronectin. Cold Spring Harbor Symposia On Quantitative Biology. 46: 659-70. PMID 7049533 DOI: 10.1101/SQB.1982.046.01.062  0.36
1982 Wagner DD, Hynes RO. Fibronectin-coated beads are endocytosed by cells and align with microfilament bundles. Experimental Cell Research. 140: 373-81. PMID 6889536 DOI: 10.1016/0014-4827(82)90126-4  0.32
1981 Van De Water L, Schroeder S, Crenshaw EB, Hynes RO. Phagocytosis of gelatin-latex particles by a murine macrophage line is dependent on fibronectin and heparin Journal of Cell Biology. 90: 32-39. PMID 7251676 DOI: 10.1083/jcb.90.1.32  1
1981 Mayer BW, Hay ED, Hynes RO. Immunocytochemical localization of fibronectin in embryonic chick trunk and area vasculosa. Developmental Biology. 82: 267-86. PMID 7014292 DOI: 10.1016/0012-1606(81)90451-6  1
1980 Senger DR, Wirth DF, Hynes RO. Transformation-specific secreted phosophoproteins. Nature. 286: 619-21. PMID 7402340 DOI: 10.1038/286619a0  1
1980 Senger DR, Wirth DF, Bryant C, Hynes RO. Transformation-specific secreted proteins. Cold Spring Harbor Symposia On Quantitative Biology. 44: 651-7. PMID 6933047  1
1979 Hynes RO, Destree AT, Perkins ME, Wagner DD. Cell surface fibronectin and oncogenic transformation. Journal of Supramolecular Structure. 11: 95-104. PMID 522486 DOI: 10.1002/jss.400110110  0.36
1979 Cifone MA, Hynes RO, Baker RM. Characteristics of concanavalin A-resistant Chinese hamster ovary cells and certain revertants Journal of Cellular Physiology. 100: 39-54. PMID 468920 DOI: 10.1002/jcp.1041000105  1
1979 Senger DR, Wirth DF, Hynes RO. Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell. 16: 885-93. PMID 88265 DOI: 10.1016/0092-8674(79)90103-X  1
1978 Senger DR, Hynes RO. C3 component of complement secreted by established cell lines. Cell. 15: 375-84. PMID 569023 DOI: 10.1016/0092-8674(78)90006-5  1
1978 Hynes RO, Ali IU, Destree AT, Mautner V, Perkins ME, Senger DR, Wagner DD, Smith KK. A large glycoprotein lost from the surfaces of transformed cells. Annals of the New York Academy of Sciences. 312: 317-42. PMID 386882 DOI: 10.1111/j.1749-6632.1978.tb16811.x  1
1976 Hynes RO, Martin GS, Shearer M, Critchley DR, Epstein CJ. Viral transformation of rat myoblasts: effects on fusion and surface properties. Developmental Biology. 48: 35-46. PMID 173598 DOI: 10.1016/0012-1606(76)90043-9  1
1975 Graham JM, Hynes RO. Isolation and characterization of a cell-surface fraction from hamster-embryo fibroblasts Biochemical Society Transactions. 3: 761-763. PMID 172389 DOI: 10.1042/bst0030761  1
1972 Hynes RO, Gross PR. Informational RNA sequences in early sea urchin embryos. Biochimica Et Biophysica Acta. 259: 104-11. PMID 5062411 DOI: 10.1016/0005-2787(72)90477-7  1
1972 Hynes RO, Greenhouse GA, Minkoff R, Gross PR. Properties of the three cell types in sixteen-cell sea urchin embryos: RNA synthesis. Developmental Biology. 27: 457-78. PMID 5029494 DOI: 10.1016/0012-1606(72)90186-8  1
1972 Hynes RO, Raff RA, Gross PR. Properties of the three cell types in sixteen-cell sea urchin embryos: aggregation and microtuble protein synthesis. Developmental Biology. 27: 150-64. PMID 5019934 DOI: 10.1016/0012-1606(72)90094-2  1
1971 Greenhouse GA, Hynes RO, Gross PR. Sea urchin embryos are permeable to actinomycin. Science (New York, N.Y.). 171: 686-9. PMID 5540310  1
1970 Hynes RO, Gross PR. A method for separating cells from early sea urchin embryos. Developmental Biology. 21: 383-402. PMID 5436900 DOI: 10.1016/0012-1606(70)90131-4  1
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