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Richard O. Hynes - Publications

Massachusetts Institute of Technology, Cambridge, MA, United States 
Integrins, Focal Adhesion

239 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Rickelt S, Neyaz A, Condon C, Whittaker CA, Zaidi AH, Taylor MS, Abbruzzese G, Mattia AR, Zukerberg L, Shroff SG, Yilmaz OH, Yılmaz O, Wu EY, Choi WT, Jobe BA, ... ... Hynes RO, et al. Agrin loss in Barrett's esophagus-related neoplasia and its utility as a diagnostic and predictive biomarker. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 34785582 DOI: 10.1158/1078-0432.CCR-21-2822  0.532
2020 Benjamin DC, Kang JH, Hamza B, King EM, Lamar JM, Manalis SR, Hynes RO. YAP Enhances Tumor Cell Dissemination by Promoting Intravascular Motility and Re-entry into Systemic Circulation. Cancer Research. PMID 32591412 DOI: 10.1158/0008-5472.Can-20-0212  0.342
2020 Hebert JD, Tian C, Lamar JM, Rickelt S, Abbruzzese G, Liu X, Hynes RO. The scaffold protein IQGAP1 is crucial for extravasation and metastasis. Scientific Reports. 10: 2439. PMID 32051509 DOI: 10.1038/S41598-020-59438-W  0.365
2020 Tian C, Öhlund D, Rickelt S, Lidström T, Huang Y, Hao L, Zhao RT, Franklin O, Bhatia SN, Tuveson DA, Hynes RO. Cancer-cell-derived matrisome proteins promote metastasis in pancreatic ductal adenocarcinoma. Cancer Research. PMID 32029550 DOI: 10.1158/0008-5472.Can-19-2578  0.371
2020 Hebert JD, Myers SA, Naba A, Abbruzzese G, Lamar J, Carr SA, Hynes RO. Proteomic profiling of the ECM of xenograft breast cancer metastases in different organs reveals distinct metastatic niches. Cancer Research. PMID 32019869 DOI: 10.1158/0008-5472.Can-19-2961  0.365
2019 Tian C, Clauser KR, Öhlund D, Rickelt S, Huang Y, Gupta M, Mani DR, Carr SA, Tuveson DA, Hynes RO. Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 31484774 DOI: 10.1073/Pnas.1908626116  0.383
2019 Xie YJ, Dougan M, Jailkhani N, Ingram J, Fang T, Kummer L, Momin N, Pishesha N, Rickelt S, Hynes RO, Ploegh H. Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 30936321 DOI: 10.1073/Pnas.1817147116  0.302
2018 Lamar JM, Xiao Y, Norton E, Jiang ZG, Gerhard GM, Kooner S, Warren JSA, Hynes RO. SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis. The Journal of Biological Chemistry. PMID 30559289 DOI: 10.1074/Jbc.Ra118.004364  0.317
2018 Chen MB, Hajal C, Benjamin DC, Yu C, Azizgolshani H, Hynes RO, Kamm RD. Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation. Proceedings of the National Academy of Sciences of the United States of America. PMID 29915060 DOI: 10.1073/Pnas.1715932115  0.35
2018 Naba A, Clauser KR, Carr SA, Hynes RO. Abstract 5004: Profiling the extracellular matrix landscape of tumor microenvironments using proteomics Cancer Research. 78: 5004-5004. DOI: 10.1158/1538-7445.Am2018-5004  0.327
2017 Naba A, Pearce OM, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO. CHARACTERIZATION OF THE EXTRACELLULAR MATRIX OF NORMAL AND DISEASED TISSUES USING PROTEOMICS. Journal of Proteome Research. PMID 28675934 DOI: 10.1021/Acs.Jproteome.7B00191  0.318
2017 Turner CJ, Badu-Nkansah K, Hynes RO. Endothelium-derived fibronectin regulates neonatal vascular morphogenesis in an autocrine fashion. Angiogenesis. PMID 28667352 DOI: 10.1007/S10456-017-9563-8  0.326
2017 Gocheva V, Naba A, Bhutkar A, Guardia T, Miller KM, Li CM, Dayton TL, Sanchez-Rivera FJ, Kim-Kiselak C, Jailkhani N, Winslow MM, Del Rosario A, Hynes RO, Jacks T. Quantitative proteomics identify Tenascin-C as a promoter of lung cancer progression and contributor to a signature prognostic of patient survival. Proceedings of the National Academy of Sciences of the United States of America. PMID 28652369 DOI: 10.1073/Pnas.1707054114  0.307
2017 Glavey SV, Naba A, Manier S, Clauser K, Tahri S, Park J, Reagan MR, Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, O'Dwyer ME, Asara JM, Palumbo A, ... ... Hynes RO, et al. Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. Leukemia. PMID 28344315 DOI: 10.1038/Leu.2017.102  0.336
2017 Ragelle H, Naba A, Larson BL, Zhou F, Prijić M, Whittaker CA, Del Rosario A, Langer R, Hynes RO, Anderson DG. Comprehensive proteomic characterization of stem cell-derived extracellular matrices. Biomaterials. 128: 147-159. PMID 28327460 DOI: 10.1016/J.Biomaterials.2017.03.008  0.643
2017 Zhu G, Zhang Q, Reddy EC, Carrim N, Chen Y, Xu XR, Xu M, Wang Y, Hou Y, Ma L, Li Y, Rui M, Petruzziello T, Lavalle C, Stratton TW, ... ... Hynes RO, et al. Integrin PSI domain has endogenous thiol isomerase function and is a novel target for anti-platelet therapy. Blood. PMID 28122739 DOI: 10.1182/Blood-2016-07-729400  0.332
2017 Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO. Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. Scientific Reports. 7: 40495. PMID 28071719 DOI: 10.1038/Srep40495  0.315
2016 Li R, Hebert JD, Lee TA, Xing H, Boussommier-Calleja A, Hynes RO, Lauffenburger DA, Kamm RD. Macrophage-secreted TNFα and TGFβ1 Influence Migration Speed and Persistence of Cancer Cells in 3D Tissue Culture via Independent Pathways. Cancer Research. PMID 27872091 DOI: 10.1158/0008-5472.Can-16-0442  0.345
2016 Carmona G, Perera U, Gillett C, Naba A, Law AL, Sharma VP, Wang J, Wyckoff J, Balsamo M, Mosis F, De Piano M, Monypenny J, Woodman N, McConnell RE, Mouneimne G, ... ... Hynes RO, et al. Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE. Oncogene. PMID 26996666 DOI: 10.1038/Onc.2016.47  0.315
2016 Chen MB, Lamar JM, Li R, Hynes RO, Kamm RD. Elucidation of the roles of tumor integrin ß1 in the extravasation stage of the metastasis cascade. Cancer Research. PMID 26988988 DOI: 10.1158/0008-5472.Can-15-1325  0.361
2016 Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, et al. Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression. Cancer Discovery. PMID 26811325 DOI: 10.1158/2159-8290.Cd-15-1183  0.345
2016 Oudin MJ, Jonas O, Kosciuk T, Broye L, Wyckoff J, Klazen J, Lamar J, Asokan S, Whittaker C, Langer R, Cima M, Wisinski K, Hynes R, Lauffenburger D, Keely P, et al. Abstract PR15: Haptotaxis and direct remodeling of the extracellular matrix by tumor cells is important for metastasis Cancer Research. 76. DOI: 10.1158/1538-7445.Tummet15-Pr15  0.38
2015 Shaw Bagnall J, Byun S, Begum S, Miyamoto DT, Hecht VC, Maheswaran S, Stott SL, Toner M, Hynes RO, Manalis SR. Deformability of Tumor Cells versus Blood Cells. Scientific Reports. 5: 18542. PMID 26679988 DOI: 10.1038/Srep18542  0.343
2015 Heilmann S, Ratnakumar K, Langdon E, Kansler E, Kim I, Campbell NR, Perry E, McMahon A, Kaufman C, van Rooijen E, Lee W, Iacobuzio-Donahue C, Hynes R, Zon L, Xavier J, et al. A quantitative system for studying metastasis using transparent zebrafish. Cancer Research. PMID 26282170 DOI: 10.1158/0008-5472.Can-14-3319  0.359
2015 Naba A, Clauser KR, Hynes RO. Enrichment of Extracellular Matrix Proteins from Tissues and Digestion into Peptides for Mass Spectrometry Analysis. Journal of Visualized Experiments : Jove. e53057. PMID 26273955 DOI: 10.3791/53057  0.343
2015 Naba A, Clauser KR, Ding H, Whittaker CA, Carr SA, Hynes RO. The extracellular matrix: Tools and insights for the "omics" era. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 26163349 DOI: 10.1016/J.Matbio.2015.06.003  0.606
2015 Murphy PA, Begum S, Hynes RO. Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors. Plos One. 10: e0120872. PMID 25807551 DOI: 10.1371/Journal.Pone.0120872  0.327
2015 Tian C, Olund D, Tuveson D, Hynes RO. Abstract A45: Understanding the roles of extracellular matrix proteins in pancreatic ductal adenocarcinoma progression and metastasis Cancer Research. 75. DOI: 10.1158/1538-7445.Panca2014-A45  0.338
2015 Chen MB, Lamar JM, Kamm RD, Hynes RO. Abstract 306: Role of tumor beta-1 integrin in the tumor cell extravasation cascade Cancer Research. 75: 306-306. DOI: 10.1158/1538-7445.Am2015-306  0.371
2015 Tian C, Ohlund D, Clauser K, Carr SA, Tuveson DA, Hynes RO. Abstract 1819: Profiling of extracellular matrix proteins in pancreatic ductal adenocarcinoma progression and metastasis Cancer Research. 75: 1819-1819. DOI: 10.1158/1538-7445.Am2015-1819  0.335
2014 Hynes RO. Stretching the boundaries of extracellular matrix research. Nature Reviews. Molecular Cell Biology. 15: 761-3. PMID 25574535 DOI: 10.1038/Nrm3908  0.35
2014 Naba A, Clauser KR, Whittaker CA, Carr SA, Tanabe KK, Hynes RO. Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. Bmc Cancer. 14: 518. PMID 25037231 DOI: 10.1186/1471-2407-14-518  0.613
2014 Labelle M, Begum S, Hynes RO. Platelets guide the formation of early metastatic niches. Proceedings of the National Academy of Sciences of the United States of America. 111: E3053-61. PMID 25024172 DOI: 10.1073/Pnas.1411082111  0.373
2014 Turner CJ, Badu-Nkansah K, Crowley D, van der Flier A, Hynes RO. Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation. Developmental Biology. 392: 381-92. PMID 24858485 DOI: 10.1016/J.Ydbio.2014.05.006  0.334
2014 Naba A, Clauser KR, Lamar JM, Carr SA, Hynes RO. Extracellular matrix signatures of human mammary carcinoma identify novel metastasis promoters. Elife. 3: e01308. PMID 24618895 DOI: 10.7554/Elife.01308  0.333
2014 Glavey S, Naba A, Manier S, Gambella M, Rocci A, Sacco A, Asara JM, Moschetta M, Reagan MR, Mishima Y, Kawano Y, Roccaro AM, Palumbo A, Hynes RO, Ghobrial IM. Proteomic Characterization of the Multiple Myeloma Bone Marrow Extracellular Matrix Blood. 124: 2051-2051. DOI: 10.1182/Blood.V124.21.2051.2051  0.354
2014 Glavey SV, Naba A, Gambella M, Rocci A, Sacco A, Asara J, Palumbo A, Hynes RO, Roccaro AM, Ghobrial IM. Abstract 4855: Proteomic characterization of the extracellular matrix in multiple myeloma Cancer Research. 74: 4855-4855. DOI: 10.1158/1538-7445.Am2014-4855  0.345
2013 Yao X, Labelle M, Lamb CR, Dugan JM, Williamson CA, Spencer DR, Christ KR, Keating RO, Lee WD, Paradis GA, Begum S, Hynes RO, Wittrup KD. Determination of 35 cell surface antigen levels in malignant pleural effusions identifies CD24 as a marker of disseminated tumor cells. International Journal of Cancer. Journal International Du Cancer. 133: 2925-33. PMID 23775727 DOI: 10.1002/Ijc.28312  0.332
2013 Miller PG, Al-Shahrour F, Hartwell KA, Chu LP, Järås M, Puram RV, Puissant A, Callahan KP, Ashton J, McConkey ME, Poveromo LP, Cowley GS, Kharas MG, Labelle M, Shterental S, ... ... Hynes RO, et al. In Vivo RNAi screening identifies a leukemia-specific dependence on integrin beta 3 signaling. Cancer Cell. 24: 45-58. PMID 23770013 DOI: 10.1016/J.Ccr.2013.05.004  0.35
2013 Hynes RO, Begum S, Labelle M. Platelets, Tumor Cell Invasiveness, and Metastasis Blood. 122: SCI-31-SCI-31. DOI: 10.1182/Blood.V122.21.Sci-31.Sci-31  0.359
2012 Labelle M, Hynes RO. The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination. Cancer Discovery. 2: 1091-9. PMID 23166151 DOI: 10.1158/2159-8290.Cd-12-0329  0.372
2012 Reticker-Flynn NE, Malta DF, Winslow MM, Lamar JM, Xu MJ, Underhill GH, Hynes RO, Jacks TE, Bhatia SN. A combinatorial extracellular matrix platform identifies cell-extracellular matrix interactions that correlate with metastasis. Nature Communications. 3: 1122. PMID 23047680 DOI: 10.1038/Ncomms2128  0.358
2012 Gupton SL, Riquelme D, Hughes-Alford SK, Tadros J, Rudina SS, Hynes RO, Lauffenburger D, Gertler FB. Mena binds α5 integrin directly and modulates α5β1 function. The Journal of Cell Biology. 198: 657-76. PMID 22908313 DOI: 10.1083/Jcb.201202079  0.424
2012 Lamar JM, Stern P, Liu H, Schindler JW, Jiang ZG, Hynes RO. The Hippo pathway target, YAP, promotes metastasis through its TEAD-interaction domain. Proceedings of the National Academy of Sciences of the United States of America. 109: E2441-50. PMID 22891335 DOI: 10.1073/Pnas.1212021109  0.336
2012 Li L, Welser-Alves J, van der Flier A, Boroujerdi A, Hynes RO, Milner R. An angiogenic role for the α5β1 integrin in promoting endothelial cell proliferation during cerebral hypoxia. Experimental Neurology. 237: 46-54. PMID 22721769 DOI: 10.1016/J.Expneurol.2012.06.005  0.326
2012 Hynes RO. The evolution of metazoan extracellular matrix. The Journal of Cell Biology. 196: 671-9. PMID 22431747 DOI: 10.1083/Jcb.201109041  0.324
2012 Naba A, Clauser KR, Hoersch S, Liu H, Carr SA, Hynes RO. The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices. Molecular & Cellular Proteomics : McP. 11: M111.014647. PMID 22159717 DOI: 10.1074/Mcp.M111.014647  0.371
2012 Bergmeier W, Hynes RO. Extracellular matrix proteins in hemostasis and thrombosis. Cold Spring Harbor Perspectives in Biology. 4. PMID 21937733 DOI: 10.1101/Cshperspect.A005132  0.333
2012 Hynes RO, Naba A. Overview of the matrisome--an inventory of extracellular matrix constituents and functions. Cold Spring Harbor Perspectives in Biology. 4: a004903. PMID 21937732 DOI: 10.1101/Cshperspect.A004903  0.386
2012 Hynes RO, Naba A, Hoersch S, Clauser K, Carr SA. Abstract SY28-01: Multiple changes in tumor extracellular matrices Cancer Research. 72. DOI: 10.1158/1538-7445.Am2012-Sy28-01  0.397
2012 Reticker-Flynn NE, Malta DFB, Winslow MM, Xu MJ, Lamar JM, Hynes RO, Jacks TE, Bhatia SN. Abstract 2973: Adhesion of tumor cells to ECM microarrays identifies novel ECM interactions in metastasis Cancer Research. 72: 2973-2973. DOI: 10.1158/1538-7445.Am2012-2973  0.385
2012 Schnaar R, Paulson JC, Macauley MS, Nycholat C, Pfrengle F, Rademacher C, Mahan A, Dionne K, Suscovich T, Alter G, Katoh T, Kiwamoto T, Brummet M, Bochner B, Tiemeyer M, ... ... Hynes R, et al. Program and abstracts for the 2012 Joint Meeting of the Society for Glycobiology & American Society for Matrix Biology Glycobiology. 22: 1518-1650. DOI: 10.1093/Glycob/Cws127  0.764
2011 Hynes RO. Metastatic cells will take any help they can get. Cancer Cell. 20: 689-90. PMID 22172715 DOI: 10.1016/J.Ccr.2011.11.022  0.338
2011 Labelle M, Begum S, Hynes RO. Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell. 20: 576-90. PMID 22094253 DOI: 10.1016/J.Ccr.2011.09.009  0.354
2011 Stenzel D, Lundkvist A, Sauvaget D, Busse M, Graupera M, van der Flier A, Wijelath ES, Murray J, Sobel M, Costell M, Takahashi S, Fässler R, Yamaguchi Y, Gutmann DH, Hynes RO, et al. Integrin-dependent and -independent functions of astrocytic fibronectin in retinal angiogenesis. Development (Cambridge, England). 138: 4451-63. PMID 21880786 DOI: 10.1242/Dev.071381  0.364
2011 Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes RO, Xu L. GPR56 Regulates VEGF production and angiogenesis during melanoma progression. Cancer Research. 71: 5558-68. PMID 21724588 DOI: 10.1158/0008-5472.Can-10-4543  0.413
2011 Xie L, Duncan MB, Pahler J, Sugimoto H, Martino M, Lively J, Mundel T, Soubasakos M, Rubin K, Takeda T, Inoue M, Lawler J, Hynes RO, Hanahan D, Kalluri R. Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proceedings of the National Academy of Sciences of the United States of America. 108: 9939-44. PMID 21622854 DOI: 10.1073/Pnas.1105041108  0.316
2011 Pulina MV, Hou SY, Mittal A, Julich D, Whittaker CA, Holley SA, Hynes RO, Astrof S. Essential roles of fibronectin in the development of the left-right embryonic body plan. Developmental Biology. 354: 208-20. PMID 21466802 DOI: 10.1016/J.Ydbio.2011.03.026  0.354
2011 Schachner M, Schoonmaker G, Hynes RO. Cellular and subcellular localization of LETS protein in the nervous system. Brain Research. 158: 149-58. PMID 21348357 DOI: 10.1016/0006-8993(78)90011-2  0.392
2011 Liu H, Ong SE, Badu-Nkansah K, Schindler J, White FM, Hynes RO. CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proceedings of the National Academy of Sciences of the United States of America. 108: 1379-84. PMID 21220330 DOI: 10.1073/Pnas.1017228108  0.349
2011 Labelle M, Begum S, Hynes RO. Abstract PR1: Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis Cancer Research. 71. DOI: 10.1158/1538-7445.Fbcr11-Pr1  0.351
2010 Acharya M, Mukhopadhyay S, Païdassi H, Jamil T, Chow C, Kissler S, Stuart LM, Hynes RO, Lacy-Hulbert A. αv Integrin expression by DCs is required for Th17 cell differentiation and development of experimental autoimmune encephalomyelitis in mice. The Journal of Clinical Investigation. 120: 4445-52. PMID 21099114 DOI: 10.1172/Jci43796  0.337
2010 Canault M, Certel K, Schatzberg D, Wagner DD, Hynes RO. The lack of ADAM17 activity during embryonic development causes hemorrhage and impairs vessel formation. Plos One. 5: e13433. PMID 20976179 DOI: 10.1371/Journal.Pone.0013433  0.306
2010 van der Flier A, Badu-Nkansah K, Whittaker CA, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO. Endothelial alpha5 and alphav integrins cooperate in remodeling of the vasculature during development. Development (Cambridge, England). 137: 2439-49. PMID 20570943 DOI: 10.1242/Dev.049551  0.628
2010 Xu L, Begum S, Barry M, Crowley D, Yang L, Bronson RT, Hynes RO. GPR56 plays varying roles in endogenous cancer progression. Clinical & Experimental Metastasis. 27: 241-9. PMID 20333450 DOI: 10.1007/S10585-010-9322-3  0.401
2010 Marchetti G, Escuin S, van der Flier A, De Arcangelis A, Hynes RO, Georges-Labouesse E. Integrin alpha5beta1 is necessary for regulation of radial migration of cortical neurons during mouse brain development. The European Journal of Neuroscience. 31: 399-409. PMID 20105241 DOI: 10.1111/J.1460-9568.2009.07072.X  0.315
2009 Hynes RO. The extracellular matrix: not just pretty fibrils. Science (New York, N.Y.). 326: 1216-9. PMID 19965464 DOI: 10.1126/Science.1176009  0.407
2009 Sobolev O, Stern P, Lacy-Hulbert A, Hynes RO. Natural killer cells require selectins for suppression of subcutaneous tumors. Cancer Research. 69: 2531-9. PMID 19258505 DOI: 10.1158/0008-5472.Can-08-3126  0.366
2009 Astrof S, Hynes RO. Fibronectins in vascular morphogenesis. Angiogenesis. 12: 165-75. PMID 19219555 DOI: 10.1007/S10456-009-9136-6  0.338
2008 Stern P, Astrof S, Erkeland SJ, Schustak J, Sharp PA, Hynes RO. A system for Cre-regulated RNA interference in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 13895-900. PMID 18779577 DOI: 10.1073/Pnas.0806907105  0.33
2008 Li S, Jin Z, Koirala S, Bu L, Xu L, Hynes RO, Walsh CA, Corfas G, Piao X. GPR56 regulates pial basement membrane integrity and cortical lamination. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5817-26. PMID 18509043 DOI: 10.1523/Jneurosci.0853-08.2008  0.406
2008 Xu L, Shen SS, Hoshida Y, Subramanian A, Ross K, Brunet JP, Wagner SN, Ramaswamy S, Mesirov JP, Hynes RO. Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Molecular Cancer Research : McR. 6: 760-9. PMID 18505921 DOI: 10.1158/1541-7786.Mcr-07-0344  0.403
2008 McCarty JH, Barry M, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO. Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. The American Journal of Pathology. 172: 1740-7. PMID 18467691 DOI: 10.2353/Ajpath.2008.070700  0.389
2008 Wong SY, Crowley D, Bronson RT, Hynes RO. Analyses of the role of endogenous SPARC in mouse models of prostate and breast cancer. Clinical & Experimental Metastasis. 25: 109-18. PMID 18058030 DOI: 10.1007/S10585-007-9126-2  0.323
2008 Shinde AV, Bystroff C, Wang C, Vogelezang MG, Vincent PA, Hynes RO, Van De Water L. Identification of the peptide sequences within the EIIIA (EDA) segment of fibronectin that mediate integrin alpha9beta1-dependent cellular activities. The Journal of Biological Chemistry. 283: 2858-70. PMID 17967897 DOI: 10.1074/Jbc.M708306200  0.347
2008 Eshghi S, Vogelezang MG, Hynes RO, Griffith LG, Lodish HF. α4β1 integrin and erythropoietin mediate temporally distinct steps in erythropoiesis: Integrins in red cell development (Journal of Cell Biology (2007) 177, 5, (871-880)) Journal of Cell Biology. 181: 395. DOI: 10.1083/Jcb.20070208020080326A  0.333
2007 Lacy-Hulbert A, Smith AM, Tissire H, Barry M, Crowley D, Bronson RT, Roes JT, Savill JS, Hynes RO. Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins. Proceedings of the National Academy of Sciences of the United States of America. 104: 15823-8. PMID 17895374 DOI: 10.1073/Pnas.0707421104  0.325
2007 Astrof S, Crowley D, Hynes RO. Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Developmental Biology. 311: 11-24. PMID 17706958 DOI: 10.1016/J.Ydbio.2007.07.005  0.346
2007 Wong SY, Haack H, Kissil JL, Barry M, Bronson RT, Shen SS, Whittaker CA, Crowley D, Hynes RO. Protein 4.1B suppresses prostate cancer progression and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 104: 12784-9. PMID 17640904 DOI: 10.1073/Pnas.0705499104  0.602
2007 Hynes RO. Cell-matrix adhesion in vascular development. Journal of Thrombosis and Haemostasis : Jth. 5: 32-40. PMID 17635706 DOI: 10.1111/J.1538-7836.2007.02569.X  0.377
2007 Xu L, Hynes RO. GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle (Georgetown, Tex.). 6: 160-5. PMID 17314516 DOI: 10.4161/Cc.6.2.3760  0.465
2007 Wong SY, Hynes RO. Tumor-lymphatic interactions in an activated stromal microenvironment. Journal of Cellular Biochemistry. 101: 840-50. PMID 17177186 DOI: 10.1002/Jcb.21146  0.305
2007 Zou Z, Chen H, Schmaier AA, Hynes RO, Kahn ML. Structure-function analysis reveals discrete beta3 integrin inside-out and outside-in signaling pathways in platelets. Blood. 109: 3284-90. PMID 17170121 DOI: 10.1182/Blood-2006-10-051664  0.303
2007 Xu L, Begum S, Hearn JD, Hynes RO. GPR56 binds tissue transglutaminase and inhibits melanoma tumor growth and metastasis The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A267-D  0.371
2006 Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, ... ... Hynes RO, et al. The genome of the sea urchin Strongylocentrotus purpuratus. Science (New York, N.Y.). 314: 941-52. PMID 17095691 DOI: 10.1126/Science.1133609  0.556
2006 Whittaker CA, Bergeron KF, Whittle J, Brandhorst BP, Burke RD, Hynes RO. The echinoderm adhesome. Developmental Biology. 300: 252-66. PMID 16950242 DOI: 10.1016/J.Ydbio.2006.07.044  0.664
2006 Xu L, Begum S, Hearn JD, Hynes RO. GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 103: 9023-8. PMID 16757564 DOI: 10.1073/Pnas.0602681103  0.417
2006 Wong SY, Hynes RO. Lymphatic or hematogenous dissemination: how does a metastatic tumor cell decide? Cell Cycle (Georgetown, Tex.). 5: 812-7. PMID 16627996 DOI: 10.4161/Cc.5.8.2646  0.306
2006 Staquet MJ, Couble ML, Roméas A, Connolly M, Magloire H, Hynes RO, Clezardin P, Bleicher F, Farges JC. Expression and localisation of alphav integrins in human odontoblasts. Cell and Tissue Research. 323: 457-63. PMID 16341551 DOI: 10.1007/S00441-005-0104-1  0.327
2005 Taverna D, Crowley D, Connolly M, Bronson RT, Hynes RO. A direct test of potential roles for beta3 and beta5 integrins in growth and metastasis of murine mammary carcinomas. Cancer Research. 65: 10324-9. PMID 16288021 DOI: 10.1158/0008-5472.Can-04-4098  0.334
2005 McCarty JH, Cook AA, Hynes RO. An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain. Proceedings of the National Academy of Sciences of the United States of America. 102: 13479-83. PMID 16157875 DOI: 10.1073/Pnas.0506068102  0.32
2005 Fang J, Hodivala-Dilke K, Johnson BD, Du LM, Hynes RO, White GC, Wilcox DA. Therapeutic expression of the platelet-specific integrin, alphaIIbbeta3, in a murine model for Glanzmann thrombasthenia. Blood. 106: 2671-9. PMID 15972454 DOI: 10.1182/Blood-2004-12-4619  0.354
2005 Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO. Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin. Experimental Cell Research. 308: 177-87. PMID 15913605 DOI: 10.1016/J.Yexcr.2005.04.017  0.334
2004 Singh P, Reimer CL, Peters JH, Stepp MA, Hynes RO, Van De Water L. The spatial and temporal expression patterns of integrin alpha9beta1 and one of its ligands, the EIIIA segment of fibronectin, in cutaneous wound healing. The Journal of Investigative Dermatology. 123: 1176-81. PMID 15610531 DOI: 10.1111/J.0022-202X.2004.23485.X  0.327
2004 Hynes RO. The emergence of integrins: a personal and historical perspective. Matrix Biology : Journal of the International Society For Matrix Biology. 23: 333-40. PMID 15533754 DOI: 10.1016/J.Matbio.2004.08.001  0.397
2004 Astrof S, Crowley D, George EL, Fukuda T, Sekiguchi K, Hanahan D, Hynes RO. Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis. Molecular and Cellular Biology. 24: 8662-70. PMID 15367684 DOI: 10.1128/Mcb.24.19.8662-8670.2004  0.317
2004 Taverna D, Moher H, Crowley D, Borsig L, Varki A, Hynes RO. Increased primary tumor growth in mice null for beta3- or beta3/beta5-integrins or selectins. Proceedings of the National Academy of Sciences of the United States of America. 101: 763-8. PMID 14718670 DOI: 10.1073/Pnas.0307289101  0.343
2003 Hamano Y, Zeisberg M, Sugimoto H, Lively JC, Maeshima Y, Yang C, Hynes RO, Werb Z, Sudhakar A, Kalluri R. Physiological levels of tumstatin, a fragment of collagen IV alpha3 chain, are generated by MMP-9 proteolysis and suppress angiogenesis via alphaV beta3 integrin. Cancer Cell. 3: 589-601. PMID 12842087 DOI: 10.1016/S1535-6108(03)00133-8  0.347
2003 Hynes RO. Metastatic potential: generic predisposition of the primary tumor or rare, metastatic variants-or both? Cell. 113: 821-3. PMID 12837240 DOI: 10.1016/S0092-8674(03)00468-9  0.319
2003 Ni H, Yuen PS, Papalia JM, Trevithick JE, Sakai T, Fässler R, Hynes RO, Wagner DD. Plasma fibronectin promotes thrombus growth and stability in injured arterioles. Proceedings of the National Academy of Sciences of the United States of America. 100: 2415-9. PMID 12606706 DOI: 10.1073/Pnas.2628067100  0.665
2002 Whittaker CA, Hynes RO. Distribution and evolution of von Willebrand/integrin A domains: widely dispersed domains with roles in cell adhesion and elsewhere. Molecular Biology of the Cell. 13: 3369-87. PMID 12388743 DOI: 10.1091/Mbc.E02-05-0259  0.636
2002 McCarty JH, Monahan-Earley RA, Brown LF, Keller M, Gerhardt H, Rubin K, Shani M, Dvorak HF, Wolburg H, Bader BL, Dvorak AM, Hynes RO. Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Molecular and Cellular Biology. 22: 7667-77. PMID 12370313 DOI: 10.1128/Mcb.22.21.7667-7677.2002  0.324
2002 Hynes RO. A reevaluation of integrins as regulators of angiogenesis. Nature Medicine. 8: 918-21. PMID 12205444 DOI: 10.1038/Nm0902-918  0.303
2002 Francis SE, Goh KL, Hodivala-Dilke K, Bader BL, Stark M, Davidson D, Hynes RO. Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 927-33. PMID 12067900 DOI: 10.1161/01.Atv.0000016045.93313.F2  0.611
2002 Borsig L, Wong R, Hynes RO, Varki NM, Varki A. Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis. Proceedings of the National Academy of Sciences of the United States of America. 99: 2193-8. PMID 11854515 DOI: 10.1073/Pnas.261704098  0.345
2002 Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO, Hodivala-Dilke KM. Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nature Medicine. 8: 27-34. PMID 11786903 DOI: 10.1038/Nm0102-27  0.307
2002 Maeshima Y, Sudhakar A, Lively JC, Ueki K, Kharbanda S, Kahn CR, Sonenberg N, Hynes RO, Kalluri R. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (New York, N.Y.). 295: 140-3. PMID 11778052 DOI: 10.1126/Science.1065298  0.345
2001 Lawler J, Miao WM, Duquette M, Bouck N, Bronson RT, Hynes RO. Thrombospondin-1 gene expression affects survival and tumor spectrum of p53-deficient mice. The American Journal of Pathology. 159: 1949-56. PMID 11696456 DOI: 10.1016/S0002-9440(10)63042-8  0.308
2001 DiPersio CM, Trevithick JE, Hynes RO. Functional comparison of the alpha3A and alpha3B cytoplasmic domain variants of the chicken alpha3 integrin subunit. Experimental Cell Research. 268: 45-60. PMID 11461117 DOI: 10.1006/Excr.2001.5273  0.351
2001 Haack H, Hynes RO. Integrin receptors are required for cell survival and proliferation during development of the peripheral glial lineage. Developmental Biology. 233: 38-55. PMID 11319856 DOI: 10.1006/Dbio.2001.0213  0.359
2001 Bono P, Rubin K, Higgins JM, Hynes RO. Layilin, a novel integral membrane protein, is a hyaluronan receptor. Molecular Biology of the Cell. 12: 891-900. PMID 11294894 DOI: 10.1091/Mbc.12.4.891  0.352
2001 Wheeler GN, Hynes RO. The cloning, genomic organization and expression of the focal contact protein paxillin in Drosophila. Gene. 262: 291-9. PMID 11179695 DOI: 10.1016/S0378-1119(00)00512-6  0.37
2000 André P, Denis CV, Ware J, Saffaripour S, Hynes RO, Ruggeri ZM, Wagner DD. Platelets adhere to and translocate on von Willebrand factor presented by endothelium in stimulated veins. Blood. 96: 3322-8. PMID 11071623 DOI: 10.1182/Blood.V96.10.3322.H8003322_3322_3328  0.304
2000 Arroyo AG, Taverna D, Whittaker CA, Strauch UG, Bader BL, Rayburn H, Crowley D, Parker CM, Hynes RO. In vivo roles of integrins during leukocyte development and traffic: insights from the analysis of mice chimeric for alpha 5, alpha v, and alpha 4 integrins. Journal of Immunology (Baltimore, Md. : 1950). 165: 4667-75. PMID 11035110 DOI: 10.4049/Jimmunol.165.8.4667  0.592
2000 Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature. 406: 532-5. PMID 10952316 DOI: 10.1038/35020106  0.355
2000 Hynes RO, Zhao Q. The evolution of cell adhesion Journal of Cell Biology. 150: F89-F95. PMID 10908592 DOI: 10.1083/Jcb.150.2.F89  0.323
2000 McHugh KP, Hodivala-Dilke K, Zheng MH, Namba N, Jonathan L, Novack D, Feng X, Ross FP, Hynes RO, Teitelbaum SL. Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts Journal of Clinical Investigation. 105: 433-440. PMID 10683372 DOI: 10.1172/Jci8905  0.321
1999 Hynes RO. Cell adhesion: Old and new questions Trends in Cell Biology. 9: M33-M37. PMID 10611678 DOI: 10.1016/S0968-0004(99)01479-6  0.381
1999 Fox GL, Rebay I, Hynes RO. Expression of DFak56, a Drosophila homolog of vertebrate focal adhesion kinase, supports a role in cell migration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 96: 14978-83. PMID 10611323 DOI: 10.1073/Pnas.96.26.14978  0.391
1999 Hynes RO, Hodivala-Dilke KM. Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia Thrombosis and Haemostasis. 82: 481-485. PMID 10605739 DOI: 10.1055/S-0037-1615868  0.312
1999 Arroyo AG, Yang JT, Rayburn H, Hynes RO. α4 integrins regulate the proliferation/differentiation balance of multilineage hematopoietic progenitors in vivo Immunity. 11: 555-566. PMID 10591181 DOI: 10.1016/S1074-7613(00)80131-4  0.309
1999 Lyden D, Young AZ, Zagzag D, Yan W, Gerald W, O'Reilly R, Bader BL, Hynes RO, Zhuang Y, Manova K, Benezra R. Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts. Nature. 401: 670-7. PMID 10537105 DOI: 10.1038/44334  0.338
1999 Hynes RO, Bader BL, Hodivala-Dilke K. Integrins in vascular development Brazilian Journal of Medical and Biological Research. 32: 501-510. PMID 10412560 DOI: 10.1590/S0100-879X1999000500002  0.375
1999 Bloom L, Ingham KC, Hynes RO. Fibronectin regulates assembly of actin filaments and focal contacts in cultured cells via the heparin-binding site in repeat III13. Molecular Biology of the Cell. 10: 1521-36. PMID 10233160 DOI: 10.1091/Mbc.10.5.1521  0.323
1999 Anderson R, Fässler R, Georges-Labouesse E, Hynes RO, Bader BL, Kreidberg JA, Schaible K, Heasman J, Wylie C. Mouse primordial germ cells lacking β1 integrins enter the germline but fail to migrate normally to the gonads Development. 126: 1655-1664. PMID 10079228  0.305
1999 Saoncella S, Echtermeyer F, Denhez F, Nowlen JK, Mosher DF, Robinson SD, Hynes RO, Goetinck PF. Syndecan-4 signals cooperatively with integrins in a Rho-dependent manner in the assembly of focal adhesions and actin stress fibers. Proceedings of the National Academy of Sciences of the United States of America. 96: 2805-10. PMID 10077592 DOI: 10.1073/Pnas.96.6.2805  0.353
1999 Hynes RO. The dynamic dialogue between cells and matrices: Implications of fibronectin's elasticity Proceedings of the National Academy of Sciences of the United States of America. 96: 2588-2590. PMID 10077553 DOI: 10.1073/Pnas.96.6.2588  0.362
1999 Hodivala-Dilke KM, McHugh KP, Tsakiris DA, Rayburn H, Crowley D, Ullman-Culleré M, Ross FP, Coller BS, Teitelbaum S, Hynes RO. β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival Journal of Clinical Investigation. 103: 229-238. PMID 9916135 DOI: 10.1172/Jci5487  0.314
1998 Bader BL, Rayburn H, Crowley D, Hynes RO. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins Cell. 95: 507-519. PMID 9827803 DOI: 10.1016/S0092-8674(00)81618-9  0.323
1998 Hartwell DW, Mayadas TN, Berger G, Frenette PS, Rayburn H, Hynes RO, Wagner DD. Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses. The Journal of Cell Biology. 143: 1129-41. PMID 9817767 DOI: 10.1083/Jcb.143.4.1129  0.337
1998 Borowsky ML, Hynes RO. Layilin, a novel talin-binding transmembrane protein homologous with C- type lectins, is localized in membrane ruffles Journal of Cell Biology. 143: 429-442. PMID 9786953 DOI: 10.1083/Jcb.143.2.429  0.362
1998 Hodivala-Dilke KM, DiPersio CM, Kreidberg JA, Hynes RO. Novel roles for α3β1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes Journal of Cell Biology. 142: 1357-1369. PMID 9732295 DOI: 10.1083/Jcb.142.5.1357  0.347
1998 Mazo IB, Gutierrez-Ramos JC, Frenette PS, Hynes RO, Wagner DD, von Andrian UH. Hematopoietic progenitor cell rolling in bone marrow microvessels: parallel contributions by endothelial selectins and vascular cell adhesion molecule 1. The Journal of Experimental Medicine. 188: 465-74. PMID 9687524 DOI: 10.1084/Jem.188.3.465  0.352
1998 Clark EA, King WG, Brugge JS, Symons M, Hynes RO. Integrin-mediated signals regulated by members of the rho family of gtpases Journal of Cell Biology. 142: 573-586. PMID 9679153 DOI: 10.1083/Jcb.142.2.573  0.316
1998 Lawler J, Sunday M, Thibert V, Duquette M, George EL, Rayburn H, Hynes RO. Thrombospondin-1 is required for normal murine pulmonary homeostasis and its absence causes pneumonia Journal of Clinical Investigation. 101: 982-992. PMID 9486968 DOI: 10.1172/Jci1684  0.323
1997 Clark EA, Hynes RO. 1997 keystone symposium on signal transduction by cell adhesion receptors Biochimica Et Biophysica Acta - Reviews On Cancer. 1333: R9-R16. PMID 9426206 DOI: 10.1016/S0304-419X(97)00028-0  0.306
1997 George EL, Baldwin HS, Hynes RO. Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells Blood. 90: 3073-3081. PMID 9376588 DOI: 10.1182/Blood.V90.8.3073  0.357
1997 Radice GL, Ferreira-Cornwell MC, Robinson SD, Rayburn H, Chodosh LA, Takeichi M, Hynes RO. Precocious mammary gland development in P-cadherin-deficient mice. The Journal of Cell Biology. 139: 1025-32. PMID 9362520 DOI: 10.1083/Jcb.139.4.1025  0.336
1997 Hedjran F, Yeakley JM, Huh GS, Hynes RO, Rosenfeld MG. Control of alternative pre-mRNA splicing by distributed pentameric repeats. Proceedings of the National Academy of Sciences of the United States of America. 94: 12343-7. PMID 9356451 DOI: 10.1073/Pnas.94.23.12343  0.328
1997 Walter UM, Ayer LM, Manning AM, Frenette PS, Wagner DD, Hynes RO, Wolitzky BA, Issekutz AC. Generation and characterization of a novel adhesion function blocking monoclonal antibody recognizing both rat and mouse E-selectin. Hybridoma. 16: 355-61. PMID 9309426 DOI: 10.1089/Hyb.1997.16.355  0.306
1997 DiPersio CM, Hodivala-Dilke KM, Jaenisch R, Kreidberg JA, Hynes RO. alpha3beta1 Integrin is required for normal development of the epidermal basement membrane. The Journal of Cell Biology. 137: 729-42. PMID 9151677 DOI: 10.1083/Jcb.137.3.729  0.32
1997 Radice GL, Rayburn H, Matsunami H, Knudsen KA, Takeichi M, Hynes RO. Developmental defects in mouse embryos lacking N-cadherin. Developmental Biology. 181: 64-78. PMID 9015265 DOI: 10.1006/Dbio.1996.8443  0.305
1996 Yang JT, Hynes RO. Fibronectin receptor functions in embryonic cells deficient in α5β1 integrin can be replaced by α(v) integrins Molecular Biology of the Cell. 7: 1737-1748. PMID 8930896 DOI: 10.1091/Mbc.7.11.1737  0.327
1996 Yang JT, Rando TA, Mohler WA, Rayburn H, Blau HM, Hynes RO. Genetic analysis of α4 integrin functions in the development of mouse skeletal muscle Journal of Cell Biology. 135: 829-835. PMID 8909554 DOI: 10.1083/Jcb.135.3.829  0.32
1996 Georges-Labouesse EN, George EL, Rayburn H, Hynes RO. Mesodermal development in mouse embryos mutant for fibronectin Developmental Dynamics. 207: 145-156. PMID 8906418 DOI: 10.1002/(Sici)1097-0177(199610)207:2<145::Aid-Aja3>3.0.Co;2-H  0.327
1996 Arroyo AG, Yang JT, Rayburn H, Hynes RO. Differential requirements for α4 integrins during fetal and adult hematopoiesis Cell. 85: 997-1008. PMID 8674127 DOI: 10.1016/S0092-8674(00)81301-X  0.326
1996 Clark EA, Hynes RO. Ras activation is necessary for integrin-mediated activation of extracellular signal-regulated kinase 2 and cytosolic phospholipase A 2 but not for cytoskeletal organization Journal of Biological Chemistry. 271: 14814-14818. PMID 8663348 DOI: 10.1074/Jbc.271.25.14814  0.303
1995 Zhang S, Holmes TC, DiPersio CM, Hynes RO, Su X, Rich A. Self-complementary oligopeptide matrices support mammalian cell attachment. Biomaterials. 16: 1385-93. PMID 8590765 DOI: 10.1016/0142-9612(95)96874-Y  0.327
1995 George EL, Hynes RO. Gene targeting and generation of mutant mice for studies of cell-extracellular matrix interactions Methods in Enzymology. 245: 386-420. PMID 7760744 DOI: 10.1016/0076-6879(94)45021-8  0.331
1995 Peters JH, Trevithick JE, Johnson P, Hynes RO. Expression of the alternatively spliced EIIIB segment of fibronectin Cell Communication and Adhesion. 3: 67-89. PMID 7538416 DOI: 10.3109/15419069509081278  0.319
1995 Johnson R, Mayadas T, Frenette P, Mebius R, Subramaniam M, Lacasce A, Hynes R, Wagner D. Blood cell dynamics in P-selectin-deficient mice Blood. 86: 1106-1114. DOI: 10.1182/Blood.V86.3.1106.Bloodjournal8631106  0.307
1994 Spring J, Paine-Saunders SE, Hynes RO, Bernfield M. Drosophila syndecan: Conservation of a cell-surface heparan sulfate proteoglycan Proceedings of the National Academy of Sciences of the United States of America. 91: 3334-3338. PMID 8159748 DOI: 10.1073/Pnas.91.8.3334  0.37
1994 Hynes RO. The impact of molecular biology on models for cell adhesion. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 16: 663-9. PMID 7980493 DOI: 10.1002/Bies.950160912  0.32
1994 Gotwals PJ, Fessler LI, Wehrli M, Hynes RO. Drosophila PS1 integrin is a laminin receptor and differs in ligand specificity from PS2. Proceedings of the National Academy of Sciences of the United States of America. 91: 11447-51. PMID 7972082 DOI: 10.1073/Pnas.91.24.11447  0.355
1994 Huh GS, Hynes RO. Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element. Genes & Development. 8: 1561-74. PMID 7958840 DOI: 10.1101/Gad.8.13.1561  0.306
1994 Gotwals PJ, Paine-Saunders SE, Stark KA, Hynes RO. Drosophila integrins and their ligands Current Opinion in Cell Biology. 6: 734-739. PMID 7833052 DOI: 10.1016/0955-0674(94)90101-5  0.31
1994 Hynes RO. Genetic analyses of cell-matrix interactions in development. Current Opinion in Genetics & Development. 4: 569-74. PMID 7524834 DOI: 10.1016/0959-437X(94)90074-D  0.353
1994 Stepp MA, Urry LA, Hynes RO. Expression of α4 integrin mRNA and protein and fibronectin in the early chicken embryo Cell Communication and Adhesion. 2: 359-375. DOI: 10.3109/15419069409014210  0.346
1993 Huh GS, Hynes RO. Elements regulating an alternatively spliced exon of the rat fibronectin gene. Molecular and Cellular Biology. 13: 5301-14. PMID 8355683 DOI: 10.1128/mcb.13.9.5301-5314.1993  0.304
1993 Mayadas TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell. 74: 541-54. PMID 7688665 DOI: 10.1016/0092-8674(93)80055-J  0.325
1993 Heasman J, Hynes RO, Swan AP, Thomas V, Wylie CC. Primordial germ cells of Xenopus embryos: the role of fibronectin in their adhesion during migration. Cell. 27: 437-47. PMID 6101198 DOI: 10.1016/0092-8674(81)90385-8  0.393
1992 Hynes RO, Lander AD. Contact and adhesive specificities in the associations, migrations, and targeting of cells and axons. Cell. 68: 303-22. PMID 1733501 DOI: 10.1016/0092-8674(92)90472-O  0.358
1992 DeSimone DW, Norton PA, Hynes RO. Identification and characterization of alternatively spliced fibronectin mRNAs expressed in early Xenopus embryos Developmental Biology. 149: 357-369. PMID 1730390 DOI: 10.1016/0012-1606(92)90291-N  0.636
1992 Hynes RO. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 69: 11-25. PMID 1555235 DOI: 10.1016/0092-8674(92)90115-S  0.32
1992 Hynes RO. Specificity of cell adhesion in development: the cadherin superfamily. Current Opinion in Genetics & Development. 2: 621-4. PMID 1525517 DOI: 10.1016/S0959-437X(05)80182-0  0.387
1992 Hynes RO, George EL, Georges EN, Guan JL, Rayburn H, Yang JT. Toward a genetic analysis of cell-matrix adhesion. Cold Spring Harbor Symposia On Quantitative Biology. 57: 249-58. PMID 1339663 DOI: 10.1101/Sqb.1992.057.01.030  0.52
1991 Guan JL, Trevithick JE, Hynes RO. Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein. Cell Regulation. 2: 951-64. PMID 1725602 DOI: 10.1091/Mbc.2.11.951  0.553
1990 Norton PA, Hynes RO. In vitro splicing of fibronectin pre-mRNAs. Nucleic Acids Research. 18: 4089-97. PMID 2377454 DOI: 10.1093/Nar/18.14.4089  0.3
1990 Guan JL, Trevithick JE, Hynes RO. Retroviral expression of alternatively spliced forms of rat fibronectin. The Journal of Cell Biology. 110: 833-47. PMID 2307710 DOI: 10.1083/Jcb.110.3.833  0.561
1990 Guan JL, Hynes RO. Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1. Cell. 60: 53-61. PMID 2295088 DOI: 10.1016/0092-8674(90)90715-Q  0.553
1990 Rees DJG, Ades SE, Singer SJ, Hynes RO. Sequence and domain structure of talin Nature. 347: 685-689. PMID 2120593 DOI: 10.1038/347685A0  0.387
1990 Marcantonio EE, Guan JL, Trevithick JE, Hynes RO. Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis. Cell Regulation. 1: 597-604. PMID 2078570 DOI: 10.1091/Mbc.1.8.597  0.694
1989 Lawler J, Weinstein R, Hynes RO. Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors. The Journal of Cell Biology. 107: 2351-61. PMID 2848850 DOI: 10.1083/Jcb.107.6.2351  0.392
1989 Solowska J, Guan JL, Marcantonio EE, Trevithick JE, Buck CA, Hynes RO. Expression of normal and mutant avian integrin subunits in rodent cells. The Journal of Cell Biology. 109: 853-61. PMID 2788168 DOI: 10.1083/Jcb.109.2.853  0.715
1989 Ffrench-Constant C, Van de Water L, Dvorak HF, Hynes RO. Reappearance of an embryonic pattern of fibronectin splicing during wound healing in the adult rat. The Journal of Cell Biology. 109: 903-14. PMID 2760116 DOI: 10.1083/Jcb.109.2.903  0.301
1989 Hynes RO, Marcantonio EE, Stepp MA, Urry LA, Yee GH. Integrin heterodimer and receptor complexity in avian and mammalian cells. The Journal of Cell Biology. 109: 409-20. PMID 2663881 DOI: 10.1083/Jcb.109.1.409  0.637
1989 Plantefaber LC, Hynes RO. Changes in integrin receptors on oncogenically transformed cells. Cell. 56: 281-90. PMID 2521461 DOI: 10.1016/0092-8674(89)90902-1  0.391
1989 Lawler J, Hynes R. An integrin receptor on normal and thrombasthenic platelets that binds thrombospondin [see comments] Blood. 74: 2022-2027. DOI: 10.1182/Blood.V74.6.2022.Bloodjournal7462022  0.375
1988 Marcantonio EE, Hynes RO. Antibodies to the conserved cytoplasmic domain of the integrin beta 1 subunit react with proteins in vertebrates, invertebrates, and fungi. The Journal of Cell Biology. 106: 1765-72. PMID 3131349 DOI: 10.1083/Jcb.106.5.1765  0.631
1988 Norton PA, Hynes RO. Alternative splicing of chicken fibronectin in embryos and in normal and transformed cells. Molecular and Cellular Biology. 7: 4297-307. PMID 2830487 DOI: 10.1128/mcb.7.12.4297-4307.1987  0.335
1987 Patel RS, Odermatt E, Schwarzbauer JE, Hynes RO. Organization of the fibronectin gene provides evidence for exon shuffling during evolution. The Embo Journal. 6: 2565-72. PMID 3119323 DOI: 10.1002/J.1460-2075.1987.Tb02545.X  0.521
1987 Hynes RO. Integrins: a family of cell surface receptors. Cell. 48: 549-54. PMID 3028640 DOI: 10.1016/0092-8674(87)90233-9  0.37
1987 Schwarzbauer JE, Mulligan RC, Hynes RO. Efficient and stable expression of recombinant fibronectin polypeptides. Proceedings of the National Academy of Sciences of the United States of America. 84: 754-8. PMID 3027700 DOI: 10.1073/Pnas.84.3.754  0.572
1987 Hynes RO, Schwarzbauer JE, Tamkun JW. Isolation and analysis of cDNA and genomic clones of fibronectin and its receptor. Methods in Enzymology. 144: 447-63. PMID 2957568 DOI: 10.1016/0076-6879(87)44194-3  0.526
1987 DeSimone DW, Stepp MA, Patel RS, Hynes RO. The integrin family of cell surface receptors Biochemical Society Transactions. 15: 789-791. PMID 2826269 DOI: 10.1042/Bst0150789A  0.622
1987 Schwarzbauer JE, Patel RS, Fonda D, Hynes RO. Multiple sites of alternative splicing of the rat fibronectin gene transcript. The Embo Journal. 6: 2573-80. PMID 2445560 DOI: 10.1002/J.1460-2075.1987.Tb02547.X  0.541
1986 Cowin P, Kapprell HP, Franke WW, Tamkun J, Hynes RO. Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell. 46: 1063-73. PMID 3530498 DOI: 10.1016/0092-8674(86)90706-3  0.369
1986 Paul JI, Schwarzbauer JE, Tamkun JW, Hynes RO. Cell-type-specific fibronectin subunits generated by alternative splicing. The Journal of Biological Chemistry. 261: 12258-65. PMID 3528152  0.523
1986 Tamkun JW, DeSimone DW, Fonda D, Patel RS, Buck C, Horwitz AF, Hynes RO. Structure of integrin, a glycoprotein involved in the transmembrane linkage between fibronectin and actin. Cell. 46: 271-82. PMID 3487386 DOI: 10.1016/0092-8674(86)90744-0  0.638
1986 Lawler J, Hynes RO. The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins Journal of Cell Biology. 103: 1635-1648. PMID 2430973 DOI: 10.1083/Jcb.103.5.1635  0.333
1986 Hynes R, Patel R, Miller R. Migration of neuroblasts along preexisting axonal tracts during prenatal cerebellar development The Journal of Neuroscience. 6: 867-876. DOI: 10.1523/Jneurosci.06-03-00867.1986  0.307
1985 Schwarzbauer JE, Paul JI, Hynes RO. On the origin of species of fibronectin. Proceedings of the National Academy of Sciences of the United States of America. 82: 1424-8. PMID 3856272 DOI: 10.1073/Pnas.82.5.1424  0.533
1985 Gardner JM, Hynes RO. Interaction of fibronectin with its receptor on platelets Cell. 42: 439-448. PMID 2411420 DOI: 10.1016/0092-8674(85)90101-1  0.326
1985 Price J, Hynes R. Astrocytes in culture synthesize and secrete a variant form of fibronectin The Journal of Neuroscience. 5: 2205-2211. DOI: 10.1523/Jneurosci.05-08-02205.1985  0.318
1984 Lee G, Hynes R, Kirschner M. Temporal and spatial regulation of fibronectin in early Xenopus development Cell. 36: 729-740. PMID 6697394 DOI: 10.1016/0092-8674(84)90353-2  0.307
1984 Hynes RO, Schwarzbauer JE, Tamkun JW. Fibronectin: a versatile gene for a versatile protein. Ciba Foundation Symposium. 108: 75-92. PMID 6569832  0.49
1984 Tamkun JW, Schwarzbauer JE, Hynes RO. A single rat fibronectin gene generates three different mRNAs by alternative splicing of a complex exon. Proceedings of the National Academy of Sciences of the United States of America. 81: 5140-4. PMID 6089177 DOI: 10.1073/Pnas.81.16.5140  0.505
1983 Senger DR, Destree AT, Hynes RO. Complex regulation of fibronectin synthesis by cells in culture. The American Journal of Physiology. 245: C144-50. PMID 6869518 DOI: 10.1152/Ajpcell.1983.245.1.C144  0.633
1983 Schwarzbauer JE, Tamkun JW, Lemischka IR, Hynes RO. Three different fibronectin mRNAs arise by alternative splicing within the coding region. Cell. 35: 421-31. PMID 6317187 DOI: 10.1016/0092-8674(83)90175-7  0.528
1982 Lahav J, Schwartz MA, Hynes RO. Analysis of platelet adhesion with a radioactive chemical crosslinking reagent: interaction of thrombospondin with fibronectin and collagen. Cell. 31: 253-62. PMID 7159924 DOI: 10.1016/0092-8674(82)90425-1  0.503
1982 Schwartz MA, Das OP, Hynes RO. A new radioactive cross-linking reagent for studying the interactions of proteins. The Journal of Biological Chemistry. 257: 2343-9. PMID 7061425  0.43
1982 Hynes RO, Destree AT, Wagner DD. Relationships between microfilaments, cell-substratum adhesion, and fibronectin. Cold Spring Harbor Symposia On Quantitative Biology. 46: 659-70. PMID 7049533 DOI: 10.1101/Sqb.1982.046.01.062  0.358
1982 Wagner DD, Hynes RO. Fibronectin-coated beads are endocytosed by cells and align with microfilament bundles. Experimental Cell Research. 140: 373-81. PMID 6889536 DOI: 10.1016/0014-4827(82)90126-4  0.32
1981 Van De Water L, Schroeder S, Crenshaw EB, Hynes RO. Phagocytosis of gelatin-latex particles by a murine macrophage line is dependent on fibronectin and heparin Journal of Cell Biology. 90: 32-39. PMID 7251676 DOI: 10.1083/Jcb.90.1.32  0.326
1981 Mayer BW, Hay ED, Hynes RO. Immunocytochemical localization of fibronectin in embryonic chick trunk and area vasculosa. Developmental Biology. 82: 267-86. PMID 7014292 DOI: 10.1016/0012-1606(81)90451-6  0.336
1981 Courtoy PJ, Kanwar YS, Hynes RO, Farquhar MG. Fibronectin localization in the rat glomerulus. The Journal of Cell Biology. 87: 691-6. PMID 7007395 DOI: 10.1083/Jcb.87.3.691  0.366
1980 Senger DR, Wirth DF, Hynes RO. Transformation-specific secreted phosophoproteins. Nature. 286: 619-21. PMID 7402340 DOI: 10.1038/286619A0  0.626
1980 Senger DR, Wirth DF, Bryant C, Hynes RO. Transformation-specific secreted proteins. Cold Spring Harbor Symposia On Quantitative Biology. 44: 651-7. PMID 6933047 DOI: 10.1101/Sqb.1980.044.01.068  0.61
1979 Hynes RO, Destree AT, Perkins ME, Wagner DD. Cell surface fibronectin and oncogenic transformation. Journal of Supramolecular Structure. 11: 95-104. PMID 522486 DOI: 10.1002/Jss.400110110  0.399
1979 Mahdavi V, Hynes RO. Proteolytic enzymes in normal and transformed cells. Biochimica Et Biophysica Acta. 583: 167-78. PMID 444559 DOI: 10.1016/0304-4165(79)90424-0  0.336
1979 Critchley DR, England MA, Wakely J, Hynes RO. Distribution of fibronectin in the ectoderm of gastrulating chick embryos Nature. 280: 498-500. PMID 379654 DOI: 10.1038/280498A0  0.375
1979 Hynes RO, Destree AT. Relationships between fibronectin (LETS protein) and actin. Cell. 15: 875-86. PMID 365353 DOI: 10.1016/0092-8674(78)90272-6  0.364
1979 Graham JM, Hynes RO, Rowlatt C, Sandall JK. Cell surface coat of hamster fibroblasts. Annals of the New York Academy of Sciences. 312: 221-39. PMID 291362 DOI: 10.1111/J.1749-6632.1978.Tb16805.X  0.368
1979 Senger DR, Wirth DF, Hynes RO. Transformed mammalian cells secrete specific proteins and phosphoproteins. Cell. 16: 885-93. PMID 88265 DOI: 10.1016/0092-8674(79)90103-X  0.641
1978 Ali IU, Hynes RO. Effects of LETS glycoprotein on cell motility. Cell. 14: 439-46. PMID 667950 DOI: 10.1016/0092-8674(78)90129-0  0.359
1978 Ali IU, Hynes RO. Role of disulfide bonds in the attachment and function of large, external, transformation-sensitive glycoprotein at the cell surface. Biochimica Et Biophysica Acta. 510: 140-50. PMID 667030 DOI: 10.1016/0005-2736(78)90136-0  0.344
1978 Hynes RO, Destree AT, Mautner VM, Ali IU. Synthesis, secretion, and attachment of LETS glycoprotein in normal and transformed cells. Journal of Supramolecular Structure. 7: 397-408. PMID 616487 DOI: 10.1002/Jss.400070311  0.386
1978 Senger DR, Hynes RO. C3 component of complement secreted by established cell lines. Cell. 15: 375-84. PMID 569023 DOI: 10.1016/0092-8674(78)90006-5  0.614
1978 Dunham JS, Hynes RO. Differences in the sulfated macromolecules synthesized by normal and transformed hamster fibroblasts. Biochimica Et Biophysica Acta. 506: 242-55. PMID 563729 DOI: 10.1016/0005-2736(78)90395-4  0.327
1978 Hynes RO, Ali IU, Destree AT, Mautner V, Perkins ME, Senger DR, Wagner DD, Smith KK. A large glycoprotein lost from the surfaces of transformed cells. Annals of the New York Academy of Sciences. 312: 317-42. PMID 386882 DOI: 10.1111/J.1749-6632.1978.Tb16811.X  0.625
1978 Hynes RO, Destree AT. 10 nm filaments in normal and transformed cells. Cell. 13: 151-63. PMID 340048 DOI: 10.1016/0092-8674(78)90146-0  0.313
1978 Mahdavi V, Hynes RO. Effects of cocultivation with transformed cells on surface proteins of normal cells. Biochimica Et Biophysica Acta. 542: 191-208. PMID 150865 DOI: 10.1016/0304-4165(78)90015-6  0.373
1977 Ali IU, Mautner V, Lanza R, Hynes RO. Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein. Cell. 11: 115-26. PMID 326414 DOI: 10.1016/0092-8674(77)90322-1  0.378
1977 Hynes RO, Destree A. Extensive disulfide bonding at the mammalian cell surface. Proceedings of the National Academy of Sciences of the United States of America. 74: 2855-9. PMID 268636 DOI: 10.1073/Pnas.74.7.2855  0.32
1976 Hynes RO, Pearistein ES. Investigations of the possible role of proteases in altering surface proteins of virally transformed hamster fibroblasts. Journal of Supramolecular Structure. 4: 1-14. PMID 1256058 DOI: 10.1002/Jss.400040102  0.35
1976 Hynes RO. Cell surface proteins and malignant transformation. Biochimica Et Biophysica Acta. 458: 73-107. PMID 779852 DOI: 10.1016/0304-419X(76)90015-9  0.339
1976 Critchley DR, Wyke JA, Hynes RO. Cell surface and metabolic labelling of the proteins of normal and transformed chicken cells. Biochimica Et Biophysica Acta. 436: 335-52. PMID 179596 DOI: 10.1016/0005-2736(76)90198-X  0.337
1975 Hynes RO, Bye JM. Density and cell cycle dependence of cell surface proteins in hamster fibroblasts. Cell. 3: 113-20. PMID 4473270 DOI: 10.1016/0092-8674(74)90114-7  0.336
1975 Hynes RO, Humphryes KC. Characterization of the external proteins of hamster fibroblasts. The Journal of Cell Biology. 62: 438-48. PMID 4372240 DOI: 10.1083/Jcb.62.2.438  0.342
1975 Graham JM, Hynes RO. Isolation and characterization of a cell-surface fraction from hamster-embryo fibroblasts Biochemical Society Transactions. 3: 761-763. PMID 172389 DOI: 10.1042/Bst0030761  0.307
1975 Hynes RO, Wyke JA. Alterations in surface proteins in chicken cells transformed by temperature-sensitive mutants of Rous sarcoma virus. Virology. 64: 492-504. PMID 166490 DOI: 10.1016/0042-6822(75)90126-9  0.309
1974 Smart JE, Hynes RO. Developmentally regulated cell surface alterations in Dictyostelium discoideum. Nature. 251: 319-321. PMID 4473716 DOI: 10.1038/251319A0  0.365
1974 Hynes RO. Alteration of cell-surface proteins by viral transformation and by proteolysis. Proceedings of the National Academy of Sciences of the United States of America. 70: 3170-4. PMID 4361679 DOI: 10.1073/Pnas.70.11.3170  0.376
1974 Hynes RO. Role of surface alterations in cell transformation: the importance of proteases and surface proteins Cell. 1: 147-156. DOI: 10.1016/0092-8674(74)90105-6  0.311
1972 Hynes RO, Gross PR. Informational RNA sequences in early sea urchin embryos. Biochimica Et Biophysica Acta. 259: 104-11. PMID 5062411 DOI: 10.1016/0005-2787(72)90477-7  0.491
1972 Hynes RO, Greenhouse GA, Minkoff R, Gross PR. Properties of the three cell types in sixteen-cell sea urchin embryos: RNA synthesis. Developmental Biology. 27: 457-78. PMID 5029494 DOI: 10.1016/0012-1606(72)90186-8  0.554
1972 Hynes RO, Raff RA, Gross PR. Properties of the three cell types in sixteen-cell sea urchin embryos: aggregation and microtuble protein synthesis. Developmental Biology. 27: 150-64. PMID 5019934 DOI: 10.1016/0012-1606(72)90094-2  0.693
1971 Greenhouse GA, Hynes RO, Gross PR. Sea urchin embryos are permeable to actinomycin. Science (New York, N.Y.). 171: 686-9. PMID 5540310 DOI: 10.1126/Science.171.3972.686  0.521
1970 Hynes RO, Gross PR. A method for separating cells from early sea urchin embryos. Developmental Biology. 21: 383-402. PMID 5436900 DOI: 10.1016/0012-1606(70)90131-4  0.561
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