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Joseph P. Noel - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Enzymology, biosynthesis, structural biology, enzyme engineering, evolution, specialized metabolism, natural products, isoprenoids, polyketides
Website:
http://www-chem.ucsd.edu/faculty/profiles/noel_joseph_p.html
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170 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Nartey CM, Koo HJ, Laurendon C, Shaik HZ, O'maille P, Noel JP, Morcos F. Coevolutionary Information Captures Catalytic Functions and Reveals Divergent Roles of Terpene Synthase Interdomain Connections. Biochemistry. PMID 38206111 DOI: 10.1021/acs.biochem.3c00578  0.726
2024 Chen A, Re RN, Davis TD, Tran K, Moriuchi YW, Wu S, La Clair JJ, Louie GV, Bowman ME, Clarke DJ, Mackay CL, Campopiano DJ, Noel JP, Burkart MD. Visualizing the Interface of Biotin and Fatty Acid Biosynthesis through SuFEx Probes. Journal of the American Chemical Society. PMID 38176024 DOI: 10.1021/jacs.3c10181  0.544
2023 Jiang Z, Chen A, Chen J, Sekhon A, Louie GV, Noel JP, La Clair JJ, Burkart MD. Masked cerulenin enables a dual-site selective protein crosslink. Chemical Science. 14: 10925-10933. PMID 37829009 DOI: 10.1039/d3sc02864j  0.556
2022 Chen A, Mindrebo JT, Davis TD, Kim WE, Katsuyama Y, Jiang Z, Ohnishi Y, Noel JP, Burkart MD. Mechanism-based cross-linking probes capture the Escherichia coli ketosynthase FabB in conformationally distinct catalytic states. Acta Crystallographica. Section D, Structural Biology. 78: 1171-1179. PMID 36048156 DOI: 10.1107/S2059798322007434  0.563
2022 Chen PY, Adak S, Chekan JR, Liscombe DK, Miyanaga A, Bernhardt P, Diethelm S, Fielding EN, George JH, Miles ZD, Murray LAM, Steele TS, Winter JM, Noel JP, Moore BS. Structural Basis of Stereospecific Vanadium-Dependent Haloperoxidase Family Enzymes in Napyradiomycin Biosynthesis. Biochemistry. PMID 35985031 DOI: 10.1021/acs.biochem.2c00338  0.36
2021 Mindrebo JT, Chen A, Kim WE, Re RN, Davis TD, Noel JP, Burkart MD. Structure and mechanistic analyses of the gating mechanism of elongating ketosynthases. Acs Catalysis. 11: 6787-6799. PMID 36187225 DOI: 10.1021/acscatal.1c00745  0.586
2020 Misson LE, Mindrebo JT, Davis TD, Patel A, McCammon JA, Noel JP, Burkart MD. Interfacial plasticity facilitates high reaction rate of FAS malonyl-CoA:ACP transacylase, FabD. Proceedings of the National Academy of Sciences of the United States of America. PMID 32929027 DOI: 10.1073/Pnas.2009805117  0.619
2020 Mindrebo JT, Misson LE, Johnson C, Noel JP, Burkart MD. Activity Mapping the Acyl Carrier Protein - Elongating Ketosynthase Interaction in Fatty Acid Biosynthesis. Biochemistry. PMID 32857494 DOI: 10.1021/Acs.Biochem.0C00605  0.615
2020 Chekan JR, McKinnie SMK, Noel JP, Moore BS. Algal neurotoxin biosynthesis repurposes the terpene cyclase structural fold into an -prenyltransferase. Proceedings of the National Academy of Sciences of the United States of America. PMID 32457155 DOI: 10.1073/Pnas.2001325117  0.455
2020 Lynch JH, Qian Y, Guo L, Maoz I, Huang XQ, Garcia AS, Louie G, Bowman ME, Noel JP, Morgan JA, Dudareva N. Modulation of auxin formation by the cytosolic phenylalanine biosynthetic pathway. Nature Chemical Biology. PMID 32284603 DOI: 10.1038/S41589-020-0519-8  0.366
2020 Mindrebo JT, Patel A, Kim WE, Davis TD, Chen A, Bartholow TG, La Clair JJ, McCammon JA, Noel JP, Burkart MD. Gating mechanism of elongating β-ketoacyl-ACP synthases. Nature Communications. 11: 1727. PMID 32265440 DOI: 10.1038/S41467-020-15455-X  0.618
2020 Patel A, MIndrebo JT, Kim WE, Chen A, Bartholow TG, Davis TD, La Clair JJ, McCammon JA, Noel JP, Burkart MD. A Computational Perspective on the Gating Mechanism of β-Ketoacyl-ACP Synthases Biophysical Journal. 118: 502a. DOI: 10.1016/J.Bpj.2019.11.2771  0.475
2020 Mindrebo JT, Misson LE, Patel A, Charov K, Noel JP, Burkart MD. The Complete Characterization of a Trapped ACYL Carrier Protein-Ketosynthase Complex Biophysical Journal. 118: 182a-183a. DOI: 10.1016/J.Bpj.2019.11.1114  0.513
2019 Vickery CR, McCulloch IP, Sonnenschein EC, Beld J, Noel JP, Burkart MD. Dissecting modular synthases through inhibition: A complementary chemical and genetic approach. Bioorganic & Medicinal Chemistry Letters. 126820. PMID 31812466 DOI: 10.1016/J.Bmcl.2019.126820  0.79
2019 Thomas ST, Louie GV, Lubin JW, Lundblad V, Noel JP. Substrate specificity and engineering of mevalonate 5-phosphate decarboxylase. Acs Chemical Biology. PMID 31268677 DOI: 10.2210/Pdb6N0X/Pdb  0.403
2019 Burke JR, La Clair JJ, Philippe RN, Pabis A, Corbella M, Jez JM, Cortina GA, Kaltenbach M, Bowman ME, Louie GV, Woods KB, Nelson AT, Tawfik DS, Kamerlin SC, Noel JP. Bifunctional Substrate Activation via an Arginine Residue Drives Catalysis in Chalcone Isomerases Acs Catalysis. 9: 8388-8396. DOI: 10.1021/Acscatal.9B01926  0.65
2018 Henry LK, Thomas ST, Widhalm JR, Lynch JH, Davis TC, Kessler SA, Bohlmann J, Noel JP, Dudareva N. Contribution of isopentenyl phosphate to plant terpenoid metabolism. Nature Plants. PMID 30127411 DOI: 10.1038/S41477-018-0220-Z  0.368
2018 Kaltenbach M, Burke JR, Dindo M, Pabis A, Munsberg FS, Rabin A, Kamerlin SCL, Noel JP, Tawfik DS. Evolution of chalcone isomerase from a noncatalytic ancestor. Nature Chemical Biology. PMID 29686356 DOI: 10.1038/S41589-018-0042-3  0.406
2018 Vickery CR, Cardenas J, Bowman M, Burkart MD, Da Silva NA, Noel JP. A coupled in vitro/in vivo approach for engineering a heterologous Type III PKS to enhance polyketide biosynthesis in Saccharomyces cerevisiae. Biotechnology and Bioengineering. PMID 29457628 DOI: 10.1002/Bit.26564  0.8
2017 Stewart C, Woods K, Macias G, Allan AC, Hellens RP, Noel JP. Molecular architectures of benzoic acid-specific type III polyketide synthases. Acta Crystallographica. Section D, Structural Biology. 73: 1007-1019. PMID 29199980 DOI: 10.1107/S2059798317016618  0.439
2017 Kersten RD, Lee S, Fujita D, Pluskal T, Kram S, Smith JE, Iwai T, Noel JP, Fujita M, Weng JK. A Red Algal Bourbonane Sesquiterpene Synthase Defined by Microgram-scale NMR-coupled Crystalline Sponge XRD Analysis. Journal of the American Chemical Society. PMID 29083151 DOI: 10.1021/Jacs.7B09452  0.802
2017 Wu CC, Baiga TJ, Downes M, La Clair JJ, Atkins AR, Richard SB, Fan W, Stockley-Noel TA, Bowman ME, Noel JP, Evans RM. Structural basis for specific ligation of the peroxisome proliferator-activated receptor δ. Proceedings of the National Academy of Sciences of the United States of America. PMID 28320959 DOI: 10.1073/Pnas.1621513114  0.353
2016 Mindrebo JT, Nartey CM, Seto Y, Burkart MD, Noel JP. Corrigendum to "Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom" [Curr Opin Struct Biol 2016, 41:233-246]. Current Opinion in Structural Biology. PMID 27884574 DOI: 10.1016/J.Sbi.2016.11.008  0.525
2016 Levsh O, Chiang YC, Tung CF, Noel JP, Wang Y, Weng JK. Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase. Biochemistry. PMID 27805809 DOI: 10.1021/Acs.Biochem.6B00887  0.8
2016 Mindrebo JT, Nartey CM, Seto Y, Burkart MD, Noel JP. Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom. Current Opinion in Structural Biology. 41: 233-246. PMID 27662376 DOI: 10.1016/J.Sbi.2016.08.005  0.605
2016 Weng JK, Ye M, Li B, Noel JP. Co-evolution of Hormone Metabolism and Signaling Networks Expands Plant Adaptive Plasticity. Cell. 166: 881-93. PMID 27518563 DOI: 10.1016/J.Cell.2016.06.027  0.534
2016 Koo HJ, Vickery CR, Xu Y, Louie GV, O'Maille PE, Bowman M, Nartey CM, Burkart MD, Noel JP. Biosynthetic potential of sesquiterpene synthases: product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants. The Journal of Antibiotics. PMID 27328867 DOI: 10.1038/Ja.2016.68  0.798
2016 Zheng Z, Guo Y, Novák O, Chen W, Ljung K, Noel JP, Chory J. Local auxin metabolism regulates environment-induced hypocotyl elongation. Nature Plants. 2: 16025. PMID 27249562 DOI: 10.1038/Nplants.2016.25  0.327
2016 El Gamal A, Agarwal V, Diethelm S, Rahman I, Schorn MA, Sneed JM, Louie GV, Whalen KE, Mincer TJ, Noel JP, Paul VJ, Moore BS. Biosynthesis of coral settlement cue tetrabromopyrrole in marine bacteria by a uniquely adapted brominase-thioesterase enzyme pair. Proceedings of the National Academy of Sciences of the United States of America. PMID 27001835 DOI: 10.1073/Pnas.1519695113  0.47
2016 Vickery CR, La Clair JJ, Burkart MD, Noel JP. Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products. Current Opinion in Chemical Biology. 31: 66-73. PMID 26851514 DOI: 10.1016/J.Cbpa.2016.01.008  0.801
2015 Kersten RD, Diedrich JK, Yates JR, Noel JP. Mechanism-Based Post-Translational Modification and Inactivation in Terpene Synthases. Acs Chemical Biology. PMID 26378620 DOI: 10.1021/Acschembio.5B00539  0.759
2015 Henry LK, Gutensohn M, Thomas ST, Noel JP, Dudareva N. Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. Proceedings of the National Academy of Sciences of the United States of America. PMID 26216978 DOI: 10.1073/Pnas.1504798112  0.389
2015 Rising KA, Crenshaw CM, Koo HJ, Subramanian T, Chehade KA, Starks C, Allen KD, Andres DA, Spielmann HP, Noel JP, Chappell J. Formation of a Novel Macrocyclic Alkaloid from the Unnatural Farnesyl Diphosphate Analogue Anilinogeranyl Diphosphate by 5-Epi-Aristolochene Synthase. Acs Chemical Biology. 10: 1729-36. PMID 25897591 DOI: 10.1021/Acschembio.5B00145  0.417
2014 Pan H, Zhou R, Louie GV, Mühlemann JK, Bomati EK, Bowman ME, Dudareva N, Dixon RA, Noel JP, Wang X. Structural studies of cinnamoyl-CoA reductase and cinnamyl-alcohol dehydrogenase, key enzymes of monolignol biosynthesis. The Plant Cell. 26: 3709-27. PMID 25217505 DOI: 10.1105/Tpc.114.127399  0.468
2014 Bomati EK, Haley JE, Noel JP, Deheyn DD. Spectral and structural comparison between bright and dim green fluorescent proteins in Amphioxus. Scientific Reports. 4: 5469. PMID 24968921 DOI: 10.1038/Srep05469  0.327
2014 Vickery CR, Kosa NM, Casavant EP, Duan S, Noel JP, Burkart MD. Structure, biochemistry, and inhibition of essential 4'-phosphopantetheinyl transferases from two species of Mycobacteria. Acs Chemical Biology. 9: 1939-44. PMID 24963544 DOI: 10.1021/Cb500263P  0.795
2014 Hoppmann C, Lacey VK, Louie GV, Wei J, Noel JP, Wang L. Genetically encoding photoswitchable click amino acids in Escherichia coli and mammalian cells. Angewandte Chemie (International Ed. in English). 53: 3932-6. PMID 24615769 DOI: 10.1002/Anie.201400001  0.347
2014 Beld J, Sonnenschein EC, Vickery CR, Noel JP, Burkart MD. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life. Natural Product Reports. 31: 61-108. PMID 24292120 DOI: 10.1039/C3Np70054B  0.786
2014 Schorn M, Zettler J, Noel JP, Dorrestein PC, Moore BS, Kaysser L. Genetic basis for the biosynthesis of the pharmaceutically important class of epoxyketone proteasome inhibitors. Acs Chemical Biology. 9: 301-9. PMID 24168704 DOI: 10.1021/Cb400699P  0.353
2013 Dellas N, Thomas ST, Manning G, Noel JP. Discovery of a metabolic alternative to the classical mevalonate pathway. Elife. 2: e00672. PMID 24327557 DOI: 10.7554/Elife.00672  0.367
2013 Teufel R, Miyanaga A, Michaudel Q, Stull F, Louie G, Noel JP, Baran PS, Palfey B, Moore BS. Flavin-mediated dual oxidation controls an enzymatic Favorskii-type rearrangement. Nature. 503: 552-6. PMID 24162851 DOI: 10.1038/Nature12643  0.331
2013 Lacey VK, Louie GV, Noel JP, Wang L. Expanding the library and substrate diversity of the pyrrolysyl-tRNA synthetase to incorporate unnatural amino acids containing conjugated rings. Chembiochem : a European Journal of Chemical Biology. 14: 2100-5. PMID 24019075 DOI: 10.1002/Cbic.201300400  0.332
2013 Weng JK, Noel JP. Chemodiversity in Selaginella: a reference system for parallel and convergent metabolic evolution in terrestrial plants. Frontiers in Plant Science. 4: 119. PMID 23717312 DOI: 10.3389/Fpls.2013.00119  0.56
2013 Guo Y, Zheng Z, La Clair JJ, Chory J, Noel JP. Smoke-derived karrikin perception by the α/β-hydrolase KAI2 from Arabidopsis. Proceedings of the National Academy of Sciences of the United States of America. 110: 8284-9. PMID 23613584 DOI: 10.1073/Pnas.1306265110  0.364
2013 Stewart C, Vickery CR, Burkart MD, Noel JP. Confluence of structural and chemical biology: plant polyketide synthases as biocatalysts for a bio-based future. Current Opinion in Plant Biology. 16: 365-72. PMID 23481348 DOI: 10.1016/J.Pbi.2013.02.004  0.8
2013 Zheng Z, Guo Y, Novák O, Dai X, Zhao Y, Ljung K, Noel JP, Chory J. Coordination of auxin and ethylene biosynthesis by the aminotransferase VAS1. Nature Chemical Biology. 9: 244-6. PMID 23377040 DOI: 10.1038/Nchembio.1178  0.327
2013 Crenshaw C, Aljadeff J, Fernandez I, Laurendon C, Defernez M, Koo H, O'Maille P, Sharpee T, Noel J. Protein Epistasis and the Biophysical Constraints on Catalytic Promiscuity Planta Medica. 79. DOI: 10.1055/S-0033-1348500  0.684
2012 Weng JK, Noel JP. The remarkable pliability and promiscuity of specialized metabolism. Cold Spring Harbor Symposia On Quantitative Biology. 77: 309-20. PMID 23269558 DOI: 10.1101/Sqb.2012.77.014787  0.577
2012 Weng JK, Noel JP. Structure-function analyses of plant type III polyketide synthases. Methods in Enzymology. 515: 317-35. PMID 22999180 DOI: 10.1016/B978-0-12-394290-6.00014-8  0.591
2012 Liscombe DK, Louie GV, Noel JP. Architectures, mechanisms and molecular evolution of natural product methyltransferases. Natural Product Reports. 29: 1238-50. PMID 22850796 DOI: 10.1039/C2Np20029E  0.424
2012 Weng JK, Philippe RN, Noel JP. The rise of chemodiversity in plants. Science (New York, N.Y.). 336: 1667-70. PMID 22745420 DOI: 10.1126/Science.1217411  0.589
2012 Zhang M, Wang XJ, Chen X, Bowman ME, Luo Y, Noel JP, Ellington AD, Etzkorn FA, Zhang Y. Structural and kinetic analysis of prolyl-isomerization/phosphorylation cross-talk in the CTD code. Acs Chemical Biology. 7: 1462-70. PMID 22670809 DOI: 10.1021/Cb3000887  0.357
2012 Ngaki MN, Louie GV, Philippe RN, Manning G, Pojer F, Bowman ME, Li L, Larsen E, Wurtele ES, Noel JP. Evolution of the chalcone-isomerase fold from fatty-acid binding to stereospecific catalysis. Nature. 485: 530-3. PMID 22622584 DOI: 10.1038/Nature11009  0.443
2012 Auldridge ME, Guo Y, Austin MB, Ramsey J, Fridman E, Pichersky E, Noel JP. Emergent decarboxylase activity and attenuation of α/β-hydrolase activity during the evolution of methylketone biosynthesis in tomato. The Plant Cell. 24: 1596-607. PMID 22523203 DOI: 10.1105/Tpc.111.093997  0.468
2011 Hess BA, Smentek L, Noel JP, O'Maille PE. Physical constraints on sesquiterpene diversity arising from cyclization of the eudesm-5-yl carbocation. Journal of the American Chemical Society. 133: 12632-41. PMID 21714557 DOI: 10.1021/Ja203342P  0.72
2011 Hothorn M, Belkhadir Y, Dreux M, Dabi T, Noel JP, Wilson IA, Chory J. Structural basis of steroid hormone perception by the receptor kinase BRI1. Nature. 474: 467-71. PMID 21666665 DOI: 10.1038/Nature10153  0.343
2011 Takimoto JK, Dellas N, Noel JP, Wang L. Stereochemical basis for engineered pyrrolysyl-tRNA synthetase and the efficient in vivo incorporation of structurally divergent non-native amino acids. Acs Chemical Biology. 6: 733-43. PMID 21545173 DOI: 10.1021/Cb200057A  0.428
2010 Louie GV, Bowman ME, Tu Y, Mouradov A, Spangenberg G, Noel JP. Structure-function analyses of a caffeic acid O-methyltransferase from perennial ryegrass reveal the molecular basis for substrate preference. The Plant Cell. 22: 4114-27. PMID 21177481 DOI: 10.1105/Tpc.110.077578  0.415
2010 Noel JP. Chemical biology: Synthetic metabolism goes green. Nature. 468: 380-1. PMID 21085165 DOI: 10.1038/468380A  0.374
2010 Tu Y, Rochfort S, Liu Z, Ran Y, Griffith M, Badenhorst P, Louie GV, Bowman ME, Smith KF, Noel JP, Mouradov A, Spangenberg G. Functional analyses of caffeic acid O-Methyltransferase and Cinnamoyl-CoA-reductase genes from perennial ryegrass (Lolium perenne). The Plant Cell. 22: 3357-73. PMID 20952635 DOI: 10.1105/Tpc.109.072827  0.377
2010 Yu G, Nguyen TT, Guo Y, Schauvinhold I, Auldridge ME, Bhuiyan N, Ben-Israel I, Iijima Y, Fridman E, Noel JP, Pichersky E. Enzymatic functions of wild tomato methylketone synthases 1 and 2. Plant Physiology. 154: 67-77. PMID 20605911 DOI: 10.1104/Pp.110.157073  0.406
2010 Dellas N, Noel JP. Mutation of archaeal isopentenyl phosphate kinase highlights mechanism and guides phosphorylation of additional isoprenoid monophosphates. Acs Chemical Biology. 5: 589-601. PMID 20392112 DOI: 10.1021/Cb1000313  0.403
2010 Zhang M, Liu J, Kim Y, Dixon JE, Pfaff SL, Gill GN, Noel JP, Zhang Y. Structural and functional analysis of the phosphoryl transfer reaction mediated by the human small C-terminal domain phosphatase, Scp1. Protein Science : a Publication of the Protein Society. 19: 974-86. PMID 20222012 DOI: 10.1002/Pro.375  0.386
2010 Faraldos JA, O'Maille PE, Dellas N, Noel JP, Coates RM. Bisabolyl-derived sesquiterpenes from tobacco 5-epi-aristolochene synthase-catalyzed cyclization of (2Z,6E)-farnesyl diphosphate. Journal of the American Chemical Society. 132: 4281-9. PMID 20201526 DOI: 10.1021/Ja909886Q  0.701
2010 Noel JP, Dellas N, Faraldos JA, Zhao M, Hess BA, Smentek L, Coates RM, O'Maille PE. Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates. Acs Chemical Biology. 5: 377-92. PMID 20175559 DOI: 10.1021/Cb900295G  0.738
2009 Lear MJ, Simon O, Foley TL, Burkart MD, Baiga TJ, Noel JP, DiPasquale AG, Rheingold AL, La Clair JJ. Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. Journal of Natural Products. 72: 1980-7. PMID 19842686 DOI: 10.1021/Np9002838  0.507
2009 Ben-Israel I, Yu G, Austin MB, Bhuiyan N, Auldridge M, Nguyen T, Schauvinhold I, Noel JP, Pichersky E, Fridman E. Multiple biochemical and morphological factors underlie the production of methylketones in tomato trichomes. Plant Physiology. 151: 1952-64. PMID 19801397 DOI: 10.1104/Pp.109.146415  0.341
2009 Koeduka T, Orlova I, Baiga TJ, Noel JP, Dudareva N, Pichersky E. The lack of floral synthesis and emission of isoeugenol in Petunia axillaris subsp. parodii is due to a mutation in the isoeugenol synthase gene. The Plant Journal : For Cell and Molecular Biology. 58: 961-9. PMID 19222805 DOI: 10.1111/J.1365-313X.2009.03834.X  0.344
2008 Savaldi-Goldstein S, Baiga TJ, Pojer F, Dabi T, Butterfield C, Parry G, Santner A, Dharmasiri N, Tao Y, Estelle M, Noel JP, Chory J. New auxin analogs with growth-promoting effects in intact plants reveal a chemical strategy to improve hormone delivery. Proceedings of the National Academy of Sciences of the United States of America. 105: 15190-5. PMID 18818305 DOI: 10.1073/Pnas.0806324105  0.339
2008 O'Maille PE, Malone A, Dellas N, Andes Hess B, Smentek L, Sheehan I, Greenhagen BT, Chappell J, Manning G, Noel JP. Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases. Nature Chemical Biology. 4: 617-23. PMID 18776889 DOI: 10.1038/Nchembio.113  0.741
2008 Eustáquio AS, Härle J, Noel JP, Moore BS. S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases. Chembiochem : a European Journal of Chemical Biology. 9: 2215-9. PMID 18720493 DOI: 10.1002/Cbic.200800341  0.371
2008 Kumano T, Richard SB, Noel JP, Nishiyama M, Kuzuyama T. Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities. Bioorganic & Medicinal Chemistry. 16: 8117-26. PMID 18682327 DOI: 10.1016/J.Bmc.2008.07.052  0.321
2008 Tao Y, Ferrer JL, Ljung K, Pojer F, Hong F, Long JA, Li L, Moreno JE, Bowman ME, Ivans LJ, Cheng Y, Lim J, Zhao Y, Ballaré CL, Sandberg G, ... Noel JP, et al. Rapid synthesis of auxin via a new tryptophan-dependent pathway is required for shade avoidance in plants. Cell. 133: 164-76. PMID 18394996 DOI: 10.1016/J.Cell.2008.01.049  0.322
2008 Baiga TJ, Guo H, Xing Y, O'Doherty GA, Dillin A, Austin MB, Noel JP, La Clair JJ. Metabolite induction of Caenorhabditis elegans dauer larvae arises via transport in the pharynx. Acs Chemical Biology. 3: 294-304. PMID 18376812 DOI: 10.1021/Cb700269E  0.315
2008 Austin MB, O'Maille PE, Noel JP. Evolving biosynthetic tangos negotiate mechanistic landscapes. Nature Chemical Biology. 4: 217-22. PMID 18347585 DOI: 10.1038/Nchembio0408-217  0.721
2008 Tello M, Kuzuyama T, Heide L, Noel JP, Richard SB. The ABBA family of aromatic prenyltransferases: broadening natural product diversity. Cellular and Molecular Life Sciences : Cmls. 65: 1459-63. PMID 18322648 DOI: 10.1007/S00018-008-7579-3  0.398
2008 Ferrer JL, Austin MB, Stewart C, Noel JP. Structure and function of enzymes involved in the biosynthesis of phenylpropanoids. Plant Physiology and Biochemistry : Ppb / Sociã©Tã© Franã§Aise De Physiologie Vã©Gã©Tale. 46: 356-70. PMID 18272377 DOI: 10.1016/J.Plaphy.2007.12.009  0.454
2008 Koeduka T, Louie GV, Orlova I, Kish CM, Ibdah M, Wilkerson CG, Bowman ME, Baiga TJ, Noel JP, Dudareva N, Pichersky E. The multiple phenylpropene synthases in both Clarkia breweri and Petunia hybrida represent two distinct protein lineages. The Plant Journal : For Cell and Molecular Biology. 54: 362-74. PMID 18208524 DOI: 10.1111/J.1365-313X.2008.03412.X  0.458
2008 Zhao N, Ferrer JL, Ross J, Guan J, Yang Y, Pichersky E, Noel JP, Chen F. Structural, biochemical, and phylogenetic analyses suggest that indole-3-acetic acid methyltransferase is an evolutionarily ancient member of the SABATH family. Plant Physiology. 146: 455-67. PMID 18162595 DOI: 10.1104/Pp.107.110049  0.415
2008 Eustáquio AS, Pojer F, Noel JP, Moore BS. Discovery and characterization of a marine bacterial SAM-dependent chlorinase. Nature Chemical Biology. 4: 69-74. PMID 18059261 DOI: 10.1038/Nchembio.2007.56  0.425
2007 Noel JP. Digging for answers, smelling a hint of success and tasting triumph. Nature Chemical Biology. 3: 690-1. PMID 17948014 DOI: 10.1038/Nchembio1107-690  0.317
2007 Louie GV, Baiga TJ, Bowman ME, Koeduka T, Taylor JH, Spassova SM, Pichersky E, Noel JP. Structure and reaction mechanism of basil eugenol synthase. Plos One. 2: e993. PMID 17912370 DOI: 10.1371/Journal.Pone.0000993  0.437
2007 Faraldos JA, Zhao Y, O'Maille PE, Noel JP, Coates RM. Interception of the enzymatic conversion of farnesyl diphosphate to 5-epi-aristolochene by using a fluoro substrate analogue: 1-fluorogermacrene A from (2E,6Z)-6-fluorofarnesyl diphosphate. Chembiochem : a European Journal of Chemical Biology. 8: 1826-33. PMID 17886322 DOI: 10.1002/Cbic.200700398  0.712
2007 Takahashi S, Yeo YS, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J. Functional characterization of premnaspirodiene oxygenase, a cytochrome P450 catalyzing regio- and stereo-specific hydroxylations of diverse sesquiterpene substrates. The Journal of Biological Chemistry. 282: 31744-54. PMID 17715131 DOI: 10.1074/Jbc.M703378200  0.745
2007 Haagen Y, Unsöld I, Westrich L, Gust B, Richard SB, Noel JP, Heide L. A soluble, magnesium-independent prenyltransferase catalyzes reverse and regular C-prenylations and O-prenylations of aromatic substrates. Febs Letters. 581: 2889-93. PMID 17543953 DOI: 10.1016/J.Febslet.2007.05.031  0.338
2007 Zhang Y, Daum S, Wildemann D, Zhou XZ, Verdecia MA, Bowman ME, Lücke C, Hunter T, Lu KP, Fischer G, Noel JP. Structural basis for high-affinity peptide inhibition of human Pin1. Acs Chemical Biology. 2: 320-8. PMID 17518432 DOI: 10.1021/Cb7000044  0.776
2007 Moffitt MC, Louie GV, Bowman ME, Pence J, Noel JP, Moore BS. Discovery of two cyanobacterial phenylalanine ammonia lyases: kinetic and structural characterization. Biochemistry. 46: 1004-12. PMID 17240984 DOI: 10.1021/Bi061774G  0.414
2007 Takahashi S, Yeo Y, Greenhagen BT, McMullin T, Song L, Maurina-Brunker J, Rosson R, Noel JP, Chappell J. Metabolic engineering of sesquiterpene metabolism in yeast. Biotechnology and Bioengineering. 97: 170-81. PMID 17013941 DOI: 10.1002/Bit.21216  0.375
2007 Noel JP, O'Maille P, Skirball JH. Identifying and manipulating evolutionary determinants linking catalytic specificities in enzymes of specialized metabolism The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A210-A  0.375
2006 Louie GV, Bowman ME, Moffitt MC, Baiga TJ, Moore BS, Noel JP. Structural determinants and modulation of substrate specificity in phenylalanine-tyrosine ammonia-lyases. Chemistry & Biology. 13: 1327-38. PMID 17185228 DOI: 10.1016/J.Chembiol.2006.11.011  0.346
2006 Liu CJ, Deavours BE, Richard SB, Ferrer JL, Blount JW, Huhman D, Dixon RA, Noel JP. Structural basis for dual functionality of isoflavonoid O-methyltransferases in the evolution of plant defense responses. The Plant Cell. 18: 3656-69. PMID 17172354 DOI: 10.1105/Tpc.106.041376  0.36
2006 Song L, Barona-Gomez F, Corre C, Xiang L, Udwary DW, Austin MB, Noel JP, Moore BS, Challis GL. Type III polyketide synthase beta-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. Journal of the American Chemical Society. 128: 14754-5. PMID 17105255 DOI: 10.1021/Ja065247W  0.364
2006 Deavours BE, Liu CJ, Naoumkina MA, Tang Y, Farag MA, Sumner LW, Noel JP, Dixon RA. Functional analysis of members of the isoflavone and isoflavanone O-methyltransferase enzyme families from the model legume Medicago truncatula. Plant Molecular Biology. 62: 715-33. PMID 17001495 DOI: 10.1007/S11103-006-9050-X  0.396
2006 Austin MB, Saito T, Bowman ME, Haydock S, Kato A, Moore BS, Kay RR, Noel JP. Biosynthesis of Dictyostelium discoideum differentiation-inducing factor by a hybrid type I fatty acid-type III polyketide synthase. Nature Chemical Biology. 2: 494-502. PMID 16906151 DOI: 10.1038/Nchembio811  0.377
2006 Pojer F, Ferrer JL, Richard SB, Nagegowda DA, Chye ML, Bach TJ, Noel JP. Structural basis for the design of potent and species-specific inhibitors of 3-hydroxy-3-methylglutaryl CoA synthases. Proceedings of the National Academy of Sciences of the United States of America. 103: 11491-6. PMID 16864776 DOI: 10.1073/Pnas.0604935103  0.362
2006 Jäger M, Zhang Y, Bieschke J, Nguyen H, Dendle M, Bowman ME, Noel JP, Gruebele M, Kelly JW. Structure-function-folding relationship in a WW domain. Proceedings of the National Academy of Sciences of the United States of America. 103: 10648-53. PMID 16807295 DOI: 10.1073/Pnas.0600511103  0.377
2006 Greenhagen BT, O'Maille PE, Noel JP, Chappell J. Identifying and manipulating structural determinates linking catalytic specificities in terpene synthases. Proceedings of the National Academy of Sciences of the United States of America. 103: 9826-31. PMID 16785438 DOI: 10.1073/Pnas.0601605103  0.758
2006 Koeduka T, Fridman E, Gang DR, Vassão DG, Jackson BL, Kish CM, Orlova I, Spassova SM, Lewis NG, Noel JP, Baiga TJ, Dudareva N, Pichersky E. Eugenol and isoeugenol, characteristic aromatic constituents of spices, are biosynthesized via reduction of a coniferyl alcohol ester. Proceedings of the National Academy of Sciences of the United States of America. 103: 10128-33. PMID 16782809 DOI: 10.1073/Pnas.0603732103  0.423
2006 Coiner H, Schröder G, Wehinger E, Liu CJ, Noel JP, Schwab W, Schröder J. Methylation of sulfhydryl groups: a new function for a family of small molecule plant O-methyltransferases. The Plant Journal : For Cell and Molecular Biology. 46: 193-205. PMID 16623883 DOI: 10.1111/J.1365-313X.2006.02680.X  0.394
2006 Lherbet C, Pojer F, Richard SB, Noel JP, Poulter CD. Absence of substrate channeling between active sites in the Agrobacterium tumefaciens IspDF and IspE enzymes of the methyl erythritol phosphate pathway. Biochemistry. 45: 3548-53. PMID 16533036 DOI: 10.1021/Bi0520075  0.375
2006 Pichersky E, Noel JP, Dudareva N. Biosynthesis of plant volatiles: nature's diversity and ingenuity. Science (New York, N.Y.). 311: 808-11. PMID 16469917 DOI: 10.1126/Science.1118510  0.42
2006 O'Maille PE, Chappell J, Noel JP. Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-epi-aristolochene synthase. Archives of Biochemistry and Biophysics. 448: 73-82. PMID 16375847 DOI: 10.1016/J.Abb.2005.10.028  0.724
2006 Testa CA, Lherbet C, Pojer F, Noel JP, Poulter CD. Cloning and expression of IspDF from Mesorhizobium loti. Characterization of a bifunctional protein that catalyzes non-consecutive steps in the methylerythritol phosphate pathway. Biochimica Et Biophysica Acta. 1764: 85-96. PMID 16203191 DOI: 10.1016/J.Bbapap.2005.08.006  0.362
2006 Yang Y, Yuan JS, Ross J, Noel JP, Pichersky E, Chen F. An Arabidopsis thaliana methyltransferase capable of methylating farnesoic acid. Archives of Biochemistry and Biophysics. 448: 123-32. PMID 16165084 DOI: 10.1016/J.Abb.2005.08.006  0.4
2006 Fridmanab E, Koezuka T, Auldridge M, Austin MB, Noel JP, Pichersky E. Chapter five Tomato glandular trichomes as a model system for exploring evolution of specialized metabolism in a single cell Recent Advances in Phytochemistry. 40: 115-130. DOI: 10.1016/S0079-9920(06)80039-0  0.341
2005 Verdecia MA, Larkin RM, Ferrer JL, Riek R, Chory J, Noel JP. [Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding]. Mã©Decine Sciences : M/S. 21: 903-4. PMID 16274634 DOI: 10.1051/Medsci/20052111903  0.778
2005 Bomati EK, Austin MB, Bowman ME, Dixon RA, Noel JP. Structural elucidation of chalcone reductase and implications for deoxychalcone biosynthesis. The Journal of Biological Chemistry. 280: 30496-503. PMID 15970585 DOI: 10.1074/Jbc.M502239200  0.454
2005 Kuzuyama T, Noel JP, Richard SB. Structural basis for the promiscuous biosynthetic prenylation of aromatic natural products. Nature. 435: 983-7. PMID 15959519 DOI: 10.1038/Nature03668  0.364
2005 Effmert U, Saschenbrecker S, Ross J, Negre F, Fraser CM, Noel JP, Dudareva N, Piechulla B. Floral benzenoid carboxyl methyltransferases: from in vitro to in planta function. Phytochemistry. 66: 1211-30. PMID 15946712 DOI: 10.1016/J.Phytochem.2005.03.031  0.457
2005 Verdecia MA, Larkin RM, Ferrer JL, Riek R, Chory J, Noel JP. Structure of the Mg-chelatase cofactor GUN4 reveals a novel hand-shaped fold for porphyrin binding. Plos Biology. 3: e151. PMID 15884974 DOI: 10.1371/Journal.Pbio.0030151  0.789
2005 Noel JP, Austin MB, Bomati EK. Structure-function relationships in plant phenylpropanoid biosynthesis. Current Opinion in Plant Biology. 8: 249-53. PMID 15860421 DOI: 10.1016/J.Pbi.2005.03.013  0.466
2005 Bomati EK, Noel JP. Structural and kinetic basis for substrate selectivity in Populus tremuloides sinapyl alcohol dehydrogenase. The Plant Cell. 17: 1598-611. PMID 15829607 DOI: 10.1105/Tpc.104.029983  0.432
2005 Ferrer JL, Zubieta C, Dixon RA, Noel JP. Crystal structures of alfalfa caffeoyl coenzyme A 3-O-methyltransferase. Plant Physiology. 137: 1009-17. PMID 15734921 DOI: 10.1104/Pp.104.048751  0.381
2005 Takahashi S, Zhao Y, O'Maille PE, Greenhagen BT, Noel JP, Coates RM, Chappell J. Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome P450 enzyme catalyzing successive hydroxylations of sesquiterpenes. The Journal of Biological Chemistry. 280: 3686-96. PMID 15522862 DOI: 10.1074/Jbc.M411870200  0.717
2004 O'Maille PE, Chappell J, Noel JP. A single-vial analytical and quantitative gas chromatography-mass spectrometry assay for terpene synthases. Analytical Biochemistry. 335: 210-7. PMID 15556559 DOI: 10.1016/J.Ab.2004.09.011  0.69
2004 Austin MB, Bowman ME, Ferrer JL, Schröder J, Noel JP. An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases. Chemistry & Biology. 11: 1179-94. PMID 15380179 DOI: 10.1016/J.Chembiol.2004.05.024  0.429
2004 Richard SB, Lillo AM, Tetzlaff CN, Bowman ME, Noel JP, Cane DE. Kinetic analysis of Escherichia coli 2-C-methyl-D-erythritol-4-phosphate cytidyltransferase, wild type and mutants, reveals roles of active site amino acids. Biochemistry. 43: 12189-97. PMID 15379557 DOI: 10.1021/Bi0487241  0.377
2004 Pott MB, Hippauf F, Saschenbrecker S, Chen F, Ross J, Kiefer I, Slusarenko A, Noel JP, Pichersky E, Effmert U, Piechulla B. Biochemical and structural characterization of benzenoid carboxyl methyltransferases involved in floral scent production in Stephanotis floribunda and Nicotiana suaveolens. Plant Physiology. 135: 1946-55. PMID 15310828 DOI: 10.1104/Pp.104.041806  0.394
2004 O'Maille PE, Tsai MD, Greenhagen BT, Chappell J, Noel JP. Gene library synthesis by structure-based combinatorial protein engineering. Methods in Enzymology. 388: 75-91. PMID 15289063 DOI: 10.1016/S0076-6879(04)88008-X  0.75
2004 Austin MB, Izumikawa M, Bowman ME, Udwary DW, Ferrer JL, Moore BS, Noel JP. Crystal structure of a bacterial type III polyketide synthase and enzymatic control of reactive polyketide intermediates. The Journal of Biological Chemistry. 279: 45162-74. PMID 15265863 DOI: 10.1074/Jbc.M406567200  0.456
2004 Hendricks CL, Ross JR, Pichersky E, Noel JP, Zhou ZS. An enzyme-coupled colorimetric assay for S-adenosylmethionine-dependent methyltransferases. Analytical Biochemistry. 326: 100-5. PMID 14769341 DOI: 10.1016/J.Ab.2003.11.014  0.352
2003 Chen F, D'Auria JC, Tholl D, Ross JR, Gershenzon J, Noel JP, Pichersky E. An Arabidopsis thaliana gene for methylsalicylate biosynthesis, identified by a biochemical genomics approach, has a role in defense. The Plant Journal : For Cell and Molecular Biology. 36: 577-88. PMID 14617060 DOI: 10.1046/J.1365-313X.2003.01902.X  0.326
2003 Izumikawa M, Shipley PR, Hopke JN, O'Hare T, Xiang L, Noel JP, Moore BS. Expression and characterization of the type III polyketide synthase 1,3,6,8-tetrahydroxynaphthalene synthase from Streptomyces coelicolor A3(2). Journal of Industrial Microbiology & Biotechnology. 30: 510-5. PMID 12905073 DOI: 10.1007/S10295-003-0075-8  0.341
2003 Zubieta C, Ross JR, Koscheski P, Yang Y, Pichersky E, Noel JP. Structural basis for substrate recognition in the salicylic acid carboxyl methyltransferase family. The Plant Cell. 15: 1704-16. PMID 12897246 DOI: 10.1105/Tpc.014548  0.431
2003 Sonnenburg ED, Bilwes A, Hunter T, Noel JP. The structure of the membrane distal phosphatase domain of RPTPalpha reveals interdomain flexibility and an SH2 domain interaction region. Biochemistry. 42: 7904-14. PMID 12834342 DOI: 10.1021/Bi0340503  0.302
2003 Downes M, Verdecia MA, Roecker AJ, Hughes R, Hogenesch JB, Kast-Woelbern HR, Bowman ME, Ferrer JL, Anisfeld AM, Edwards PA, Rosenfeld JM, Alvarez JG, Noel JP, Nicolaou KC, Evans RM. A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Molecular Cell. 11: 1079-92. PMID 12718892 DOI: 10.1016/S1097-2765(03)00104-7  0.779
2003 Austin MB, Noel JP. The chalcone synthase superfamily of type III polyketide synthases. Natural Product Reports. 20: 79-110. PMID 12636085 DOI: 10.1039/B100917F  0.431
2003 Verdecia MA, Joazeiro CA, Wells NJ, Ferrer JL, Bowman ME, Hunter T, Noel JP. Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase. Molecular Cell. 11: 249-59. PMID 12535537 DOI: 10.1016/S1097-2765(02)00774-8  0.791
2003 Noel JP, Dixon RA, Pichersky E, Zubieta C, Ferrer JL. Chapter two Structural, functional, and evolutionary basis for methylation of plant small molecules Recent Advances in Phytochemistry. 37: 37-58. DOI: 10.1016/S0079-9920(03)80017-5  0.42
2002 Moore BS, Hertweck C, Hopke JN, Izumikawa M, Kalaitzis JA, Nilsen G, O'Hare T, Piel J, Shipley PR, Xiang L, Austin MB, Noel JP. Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone. Journal of Natural Products. 65: 1956-62. PMID 12502351 DOI: 10.1021/Np020230M  0.432
2002 Zubieta C, Kota P, Ferrer JL, Dixon RA, Noel JP. Structural basis for the modulation of lignin monomer methylation by caffeic acid/5-hydroxyferulic acid 3/5-O-methyltransferase. The Plant Cell. 14: 1265-77. PMID 12084826 DOI: 10.1105/Tpc.001412  0.431
2002 Jez JM, Bowman ME, Noel JP. Expanding the biosynthetic repertoire of plant type III polyketide synthases by altering starter molecule specificity. Proceedings of the National Academy of Sciences of the United States of America. 99: 5319-24. PMID 11959984 DOI: 10.1073/Pnas.082590499  0.621
2002 Jez JM, Bowman ME, Noel JP. Role of hydrogen bonds in the reaction mechanism of chalcone isomerase. Biochemistry. 41: 5168-76. PMID 11955065 DOI: 10.1021/Bi0255266  0.61
2002 Gang DR, Lavid N, Zubieta C, Chen F, Beuerle T, Lewinsohn E, Noel JP, Pichersky E. Characterization of phenylpropene O-methyltransferases from sweet basil: Facile change of substrate specificity and convergent evolution within a plant O-methyltransferase family Plant Cell. 14: 505-519. PMID 11884690 DOI: 10.1105/Tpc.010327  0.313
2002 Richard SB, Ferrer JL, Bowman ME, Lillo AM, Tetzlaff CN, Cane DE, Noel JP. Structure and mechanism of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase. An enzyme in the mevalonate-independent isoprenoid biosynthetic pathway. The Journal of Biological Chemistry. 277: 8667-72. PMID 11786530 DOI: 10.1074/Jbc.C100739200  0.419
2002 Lu PJ, Zhou XZ, Liou YC, Noel JP, Lu KP. Critical role of WW domain phosphorylation in regulating phosphoserine binding activity and Pin1 function. The Journal of Biological Chemistry. 277: 2381-4. PMID 11723108 DOI: 10.1074/Jbc.C100228200  0.318
2002 Jez JM, Noel JP. Reaction mechanism of chalcone isomerase: pH dependence, diffusion control, and product binding differences Journal of Biological Chemistry. 277: 1361-1369. PMID 11698411 DOI: 10.1074/Jbc.M109224200  0.603
2002 Noel JP, Jez JM, Austin MB, Bowman ME, Ferrer JL. Chapter Twelve Structurally guided alteration of biosynthesis in plant type III polyketide synthases Recent Advances in Phytochemistry. 36: 197-222. DOI: 10.1016/S0079-9920(02)80028-4  0.653
2001 Jez JM, Ferrer JL, Bowman ME, Austin MB, Schröder J, Dixon RA, Noel JP. Structure and mechanism of chalcone synthase-like polyketide synthases. Journal of Industrial Microbiology & Biotechnology. 27: 393-8. PMID 11774005 DOI: 10.1038/sj/jim/7000188  0.609
2001 Jez JM, Bowman ME, Noel JP. Structure-guided programming of polyketide chain-length determination in chalcone synthase Biochemistry. 40: 14829-14838. PMID 11732902 DOI: 10.1021/Bi015621Z  0.6
2001 Richard SB, Bowman ME, Kwiatkowski W, Kang I, Chow C, Lillo AM, Cane DE, Noel JP. Structure of 4-diphosphocytidyl-2-C- methylerythritol synthetase involved in mevalonate- independent isoprenoid biosynthesis. Nature Structural Biology. 8: 641-8. PMID 11427897 DOI: 10.1038/89691  0.462
2001 Zubieta C, He XZ, Dixon RA, Noel JP. Structures of two natural product methyltransferases reveal the basis for substrate specificity in plant O-methyltransferases. Nature Structural Biology. 8: 271-9. PMID 11224575 DOI: 10.1038/85029  0.441
2001 Dixon RA, Chen F, He XZ, Noel JP, Zubieta C. Chapter Seven Properties and metabolic engineering of alfalfa phenylpropanoid pathway O-methyltransferases Recent Advances in Phytochemistry. 35: 131-154. DOI: 10.1016/S0079-9920(01)80008-3  0.418
2000 Jez JM, Austin MB, Ferrer J, Bowman ME, Schröder J, Noel JP. Structural control of polyketide formation in plant-specific polyketide synthases. Chemistry & Biology. 7: 919-30. PMID 11137815 DOI: 10.1016/S1074-5521(00)00041-7  0.608
2000 Jez JM, Noel JP. Mechanism of chalcone synthase. pKa of the catalytic cysteine and the role of the conserved histidine in a plant polyketide synthase. The Journal of Biological Chemistry. 275: 39640-6. PMID 11006298 DOI: 10.1074/Jbc.M008569200  0.623
2000 Jez JM, Bowman ME, Dixon RA, Noel JP. Structure and mechanism of the evolutionarily unique plant enzyme chalcone isomerase. Nature Structural Biology. 7: 786-91. PMID 10966651 DOI: 10.1038/79025  0.668
2000 Verdecia MA, Bowman ME, Lu KP, Hunter T, Noel JP. Structural basis for phosphoserine-proline recognition by group IV WW domains. Nature Structural Biology. 7: 639-43. PMID 10932246 DOI: 10.1038/77929  0.783
2000 Jez JM, Noel JP. A kaleidoscope of carotenoids. Nature Biotechnology. 18: 825-6. PMID 10932147 DOI: 10.1038/78425  0.51
2000 Verdecia MA, Huang H, Dutil E, Kaiser DA, Hunter T, Noel JP. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement. Nature Structural Biology. 7: 602-8. PMID 10876248 DOI: 10.1038/76838  0.793
2000 Jez JM, Ferrer JL, Bowman ME, Dixon RA, Noel JP. Dissection of malonyl-coenzyme A decarboxylation from polyketide formation in the reaction mechanism of a plant polyketide synthase. Biochemistry. 39: 890-902. PMID 10653632 DOI: 10.1021/Bi991489F  0.655
2000 Ferrer J, Jez JM, Zubieta C, Bowman ME, Noel JP. Systematic 3D-structure determination of enzymes involved in the plant phenylpropanoid pathway Acta Crystallographica Section a Foundations of Crystallography. 56: s241-s241. DOI: 10.1107/S0108767300025198  0.616
1999 Jiang G, den Hertog J, Su J, Noel J, Sap J, Hunter T. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha. Nature. 401: 606-10. PMID 10524630 DOI: 10.1038/44170  0.364
1999 Ferrer JL, Jez JM, Bowman ME, Dixon RA, Noel JP. Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Nature Structural Biology. 6: 775-84. PMID 10426957 DOI: 10.1038/11553  0.645
1998 Majeti R, Bilwes AM, Noel JP, Hunter T, Weiss A. Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge. Science (New York, N.Y.). 279: 88-91. PMID 9417031 DOI: 10.1126/Science.279.5347.88  0.306
1997 Starks CM, Back K, Chappell J, Noel JP. Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase. Science (New York, N.Y.). 277: 1815-20. PMID 9295271 DOI: 10.1126/Science.277.5333.1815  0.451
1997 Mathis JR, Back K, Starks C, Noel J, Poulter CD, Chappell J. Pre-steady-state study of recombinant sesquiterpene cyclases. Biochemistry. 36: 8340-8. PMID 9204881 DOI: 10.1021/Bi963019G  0.377
1997 Ranganathan R, Lu KP, Hunter T, Noel JP. Structural and functional analysis of the mitotic rotamase Pin1 suggests substrate recognition is phosphorylation dependent. Cell. 89: 875-86. PMID 9200606 DOI: 10.1016/S0092-8674(00)80273-1  0.598
1996 Bilwes AM, den Hertog J, Hunter T, Noel JP. Structural basis for inhibition of receptor protein-tyrosine phosphatase-alpha by dimerization. Nature. 382: 555-9. PMID 8700232 DOI: 10.1038/382555A0  0.384
1996 Starks C, Back K, Chappell J, Noel J. Structural study of sesquiterpene cyclases Acta Crystallographica Section A. 52: 120-120. DOI: 10.1107/S0108767396094366  0.323
1996 Sondeck J, Bohm A, Lambright DG, Skiba NP, Noel JP, Hamm HE, Sigler PB. Refined structures of heterotrimeric G protein complexes at high resolution Acta Crystallographica Section a Foundations of Crystallography. 52: C184-C185. DOI: 10.1107/S0108767396091921  0.559
1996 Bilwes AM, den Hertog J, Hunter T, Noel JP. Structural analysis of a dimeric state of the first intracellular domain of PTPa, a protein receptor-like tyrosine phosphatase Acta Crystallographica Section a Foundations of Crystallography. 52: C185-C185. DOI: 10.1107/S010876739609191X  0.319
1994 Lambright DG, Noel JP, Hamm HE, Sigler PB. Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Nature. 369: 621-8. PMID 8208289 DOI: 10.1038/369621A0  0.586
1994 Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB. GTPase mechanism of Gproteins from the 1.7-A crystal structure of transducin alpha-GDP-AIF-4. Nature. 372: 276-9. PMID 7969474 DOI: 10.1038/372276A0  0.565
1993 Noel JP, Hamm HE, Sigler PB. The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature. 366: 654-63. PMID 8259210 DOI: 10.1038/366654A0  0.601
1992 Dupureur CM, Yu BZ, Jain MK, Noel JP, Deng T, Li Y, Byeon IJ, Tsai MD. Phospholipase A2 engineering. Structural and functional roles of highly conserved active site residues tyrosine-52 and tyrosine-73. Biochemistry. 31: 6402-13. PMID 1633153 DOI: 10.1021/Bi00143A007  0.573
1991 Noel JP, Bingman CA, Deng TL, Dupureur CM, Hamilton KJ, Jiang RT, Kwak JG, Sekharudu C, Sundaralingam M, Tsai MD. Phospholipase A2 engineering. X-ray structural and functional evidence for the interaction of lysine-56 with substrates. Biochemistry. 30: 11801-11. PMID 1751497 DOI: 10.1021/Bi00115A010  0.565
1990 Deng TL, Noel JP, Tsai MD. A novel expression vector for high-level synthesis and secretion of foreign proteins in Escherichia coli: overproduction of bovine pancreatic phospholipase A2. Gene. 93: 229-34. PMID 2227436 DOI: 10.1016/0378-1119(90)90229-K  0.484
1990 Noel JP, Deng T, Hamilton KJ, Tsai MD. Phospholipase A2 engineering. 3. Replacement of lysine-56 by neutral residues improves catalytic efficiency significantly, alters substrate specificity, and clarifies the mechanism of interfacial recognition Journal of the American Chemical Society. 112: 3704-3706. DOI: 10.1021/Ja00165A090  0.309
1989 Noel JP, Tsai MD. Phospholipase A2 engineering: design, synthesis, and expression of a gene for bovine (pro)phospholipase A2. Journal of Cellular Biochemistry. 40: 309-20. PMID 2674160 DOI: 10.1002/Jcb.240400307  0.475
1987 Rosario-jansen T, Pownall HJ, Noel JP, Tsai M. Phospholipids Chiral at Phosphorus. 13. Stereochemical Comparison of Phospholipase A2, Lecithin-Cholesterol Acyl Transferase, and Platelet-Activating Factor Phosphorus and Sulfur and the Related Elements. 30: 601-604. DOI: 10.1080/03086648708079137  0.438
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