David A. Wink - Publications

Affiliations: 
Cancer and Inflammation program National Institutes of Health, Bethesda, MD, United States 

231 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Reddy TP, Glynn SA, Billiar TR, Wink DA, Chang JC. Targeting Nitric Oxide: Say NO to Metastasis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 36520504 DOI: 10.1158/1078-0432.CCR-22-2791  0.334
2021 Miranda KM, Ridnour LA, McGinity CL, Bhattacharyya D, Wink DA. Nitric Oxide and Cancer: When to Give and When to Take Away? Inorganic Chemistry. PMID 34694129 DOI: 10.1021/acs.inorgchem.1c02434  0.337
2020 Carvalho EM, Ridnour LA, Júnior FSG, Cabral PHB, do Nascimento NRF, Wink DA, Franco DW, de Medeiros MJC, de Lima Pontes D, Longhinotti E, de Freitas Paulo T, Bernardes-Génisson V, Chauvin R, Sousa EHS, Lopes LGF. A divergent mode of activation of a nitrosyl iron complex with unusual antiangiogenic activity. Journal of Inorganic Biochemistry. 210: 111133. PMID 32619898 DOI: 10.1016/J.Jinorgbio.2020.111133  0.366
2020 Cheng RYS, Patel NL, Back T, Basudhar D, Somasundaram V, Kalen JD, Wink DA, Ridnour LA. Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model. Journal of Visualized Experiments : Jove. PMID 32250353 DOI: 10.3791/60316  0.742
2020 Palmieri EM, Gonzalez-Cotto M, Baseler WA, Davies LC, Ghesquière B, Maio N, Rice CM, Rouault TA, Cassel T, Higashi RM, Lane AN, Fan TW, Wink DA, McVicar DW. Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase. Nature Communications. 11: 698. PMID 32019928 DOI: 10.1038/S41467-020-14433-7  0.337
2020 Basudhar D, Somasundaram V, Scheiblin DA, Kedei N, Cheng RY, Ridnour LA, McVicar DW, Lockett S, Wink DA. Abstract 6198: Regulation of cycloxygenase-2 in the tumor micro-environment improves radiation and immunotherapy Tumor Biology. DOI: 10.1158/1538-7445.Am2020-6198  0.706
2020 Fujita M, Somasundaram V, Basudhar DB, Cheng RYs, Ridnour LA, Imadome K, No JH, Bharadwaj G, Wink DA. Abstract 6071: Role of nitric oxide in the invasive pancreatic cancer cells Tumor Biology. DOI: 10.1158/1538-7445.Am2020-6071  0.435
2020 Somasundaram V, Basudhar D, McGinity C, Cheng RY, Ridnour LA, Lockett SJ, Wink DA. Abstract 2754: Inhibition of nitric oxide synthase and cyclooxygenase potentiate immune responses that control aggressive mammary tumor in a murine model Cancer Research. 80: 2754-2754. DOI: 10.1158/1538-7445.Am2020-2754  0.754
2019 Somasundaram V, Gilmore AC, Basudhar D, Palmieri EM, Scheiblin DA, Heinz WF, Cheng RYS, Ridnour LA, Altan-Bonnet G, Lockett SJ, McVicar DW, Wink DA. Inducible nitric oxide synthase-derived extracellular nitric oxide flux regulates proinflammatory responses at the single cell level. Redox Biology. 28: 101354. PMID 31683257 DOI: 10.1016/J.Redox.2019.101354  0.764
2019 Waheed S, Cheng RY, Casablanca Y, Maxwell GL, Wink DA, Syed V. Nitric Oxide Donor DETA/NO Inhibits the Growth of Endometrial Cancer Cells by Upregulating the Expression of RASSF1 and CDKN1A. Molecules (Basel, Switzerland). 24. PMID 31623109 DOI: 10.3390/Molecules24203722  0.417
2019 Wang R, Geller DA, Wink DA, Cheng B, Billiar TR. Nitric oxide and hepatocellular cancer. British Journal of Pharmacology. PMID 31423564 DOI: 10.1111/Bph.14838  0.367
2019 Fujita M, Somasundaram V, Basudhar D, Cheng RYS, Ridnour LA, Higuchi H, Imadome K, No JH, Bharadwaj G, Wink DA. Role of nitric oxide in pancreatic cancer cells exhibiting the invasive phenotype. Redox Biology. 22: 101158. PMID 30852389 DOI: 10.1016/J.Redox.2019.101158  0.765
2019 Cheng YSR, Basudhar D, Lisa R, Somasundaram V, Wink D. Abstract 2015: Downregulation of MZB1 by aminoguanidine, APOE mimetic and nitroxyl compounds associated with reduction in invasive breast tumor volume and metastasis Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2015  0.718
2019 Somasundaram V, Gilmore C, Palmieri EM, Basudhar D, Heinz W, Cheng RY, Ridnour LA, Lockett SJ, McVicar DW, Wink DA. Abstract 1186: Regulation of inducible nitric oxide synthase at the single cell level modulates the inflammatory microenvironment Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-1186  0.753
2019 Basudhar D, Somasundaram V, Scheiblin DA, Cheng RY, Lockett SJ, Wink D, Ridnour LA. Abstract 1197: Role of NOS2-COX2 inhibition in radiation-induced tumor growth delay and immuno-modulation in the tumor micro-environment Cancer Research. 79: 1197-1197. DOI: 10.1158/1538-7445.Am2019-1197  0.762
2018 Basudhar D, Bharadwaj G, Somasundaram V, Cheng RYS, Ridnour LA, Fujita M, Lockett SJ, Anderson SK, McVicar DW, Wink DA. Understanding the tumour microenvironment communication network from a NOS2/COX2 perspective. British Journal of Pharmacology. PMID 30152521 DOI: 10.1111/Bph.14488  0.734
2018 Weiss JM, Davies LC, Karwan M, Ileva L, Ozaki MK, Cheng RY, Ridnour LA, Annunziata CM, Wink DA, McVicar DW. Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors. The Journal of Clinical Investigation. PMID 29920191 DOI: 10.1172/Jci99169  0.381
2018 Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T, Akaike T. Biological Hydropersulfides and Related Polysulfides: A New Concept and Perspective in Redox Biology. Febs Letters. PMID 29754415 DOI: 10.1002/1873-3468.13090  0.303
2018 Somasundaram V, Basudhar D, Bharadwaj G, No JH, Ridnour LA, Cheng R, Fujita M, Thomas DD, Anderson SK, McVicar DW, Wink DA. Molecular Mechanisms of Nitric Oxide in Cancer Progression, Signal Transduction and Metabolism. Antioxidants & Redox Signaling. PMID 29634348 DOI: 10.1089/Ars.2018.7527  0.784
2018 Thomas K, Moody TW, Jensen RT, Tong J, Rayner CL, Barnett NL, Fairfull-Smith KE, Ridnour LA, Wink DA, Bottle SE. Design, synthesis and biological evaluation of hybrid nitroxide-based non-steroidal anti-inflammatory drugs. European Journal of Medicinal Chemistry. 147: 34-47. PMID 29421569 DOI: 10.1016/J.Ejmech.2018.01.077  0.379
2018 Somasundaram V, Basudhar D, Palmieri EM, Cheng RY, Ridnour LA, McVicar DW, Wink DA. Abstract 4497: Delineating the effects of different levels of nitric oxide produced by "M1" stimulated macrophages on tumor rejection and response to therapy Cancer Research. 78: 4497-4497. DOI: 10.1158/1538-7445.Am2018-4497  0.76
2018 Basudhar D, Glynn S, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, Cheng RY, Ridnour LA, Lockett SJ, McVicar DW, Ambs S, ... Wink DA, et al. Abstract 3789: Role of NOS2-COX2 crosstalk in tumor microenvironment of estrogen receptor-negative breast cancer and its therapeutic implications Immunology. DOI: 10.1158/1538-7445.Am2018-3789  0.74
2017 Basudhar D, Glynn SA, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, Cheng RYS, Ridnour LA, Lockett SJ, McVicar DW, Ambs S, ... Wink DA, et al. Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer. Proceedings of the National Academy of Sciences of the United States of America. PMID 29087320 DOI: 10.1073/Pnas.1709119114  0.761
2017 Thomas DD, Wink DA. NOS2 as an Emergent Player in Progression of Cancer. Antioxidants & Redox Signaling. PMID 28506076 DOI: 10.1089/Ars.2016.6835  0.445
2017 Cortese-Krott MM, Koning A, Kuhnle GG, Nagy P, Bianco C, Pasch A, Wink DA, Fukuto J, Jackson AA, van Goor H, Olson KR, Feelisch M. The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine. Antioxidants & Redox Signaling. PMID 28398072 DOI: 10.1089/Ars.2017.7083  0.33
2017 Kovacevic Z, Sahni S, Lok H, Davies MJ, Wink DA, Richardson DR. Regulation and Control of Nitric Oxide (NO) in Macrophages: Protecting the "Professional Killer Cell" from its Own Cytotoxic Arsenal via MRP1 and GSTP1. Biochimica Et Biophysica Acta. PMID 28219722 DOI: 10.1016/J.Bbagen.2017.02.021  0.378
2017 Moody TW, Ramos-Alvarez I, Perez PM, Mantey SA, Ridnour L, Wink D, Jensen RT. Endothelin causes transactivation of the EGFR and HER2 in non-small cell lung cancer cells. Peptides. PMID 28153500 DOI: 10.1016/J.Peptides.2017.01.012  0.314
2016 Walsh EM, Keane MM, Wink DA, Callagy G, Glynn SA. Review of Triple Negative Breast Cancer and the Impact of Inducible Nitric Oxide Synthase on Tumor Biology and Patient Outcomes. Critical Reviews in Oncogenesis. 21: 333-351. PMID 29431082 DOI: 10.1615/Critrevoncog.2017021307  0.418
2016 Sektioglu IM, Carretero R, Bender N, Bogdan C, Garbi N, Umansky V, Umansky L, Urban K, von Knebel-Döberitz M, Somasundaram V, Wink D, Beckhove P, Hämmerling GJ. Macrophage-derived nitric oxide initiates T-cell diapedesis and tumor rejection. Oncoimmunology. 5: e1204506. PMID 27853636 DOI: 10.1080/2162402X.2016.1204506  0.422
2016 Baseler WA, Davies LC, Quigley L, Ridnour LA, Weiss JM, Hussain SP, Wink DA, McVicar DW. Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production. Redox Biology. 10: 12-23. PMID 27676159 DOI: 10.1016/J.Redox.2016.09.005  0.3
2016 de Oliveira GA, Cheng R, Ridnour LA, Basudhar D, Somasundaram V, McVicar DW, Monteiro HP, Wink DA. Inducible Nitric Oxide Synthase (NOS2) in the Carcinogenesis of Gastrointestinal Cancers. Antioxidants & Redox Signaling. PMID 27494631 DOI: 10.1089/Ars.2016.6850  0.746
2016 Basudhar D, Somasundaram V, de Oliveira GA, Kesarwala A, Heinecke JL, Cheng RY, Glynn S, Ambs S, Wink DA, Ridnour LA. NOS2-derived NO Drives Multiple Pathways of Breast Cancer Progression. Antioxidants & Redox Signaling. PMID 27464521 DOI: 10.1089/ars.2016.6813  0.722
2016 Sousa EH, Ridnour LA, Gouveia FS, Silva CD, Wink DA, de França Lopes LG, Sadler PJ. Thiol-activated HNO release from a ruthenium anti-angiogenesis complex and HIF-1α inhibition for cancer therapy. Acs Chemical Biology. PMID 27191177 DOI: 10.1021/Acschembio.6B00222  0.788
2016 Basudhar D, Ridnour LA, Cheng R, Kesarwala AH, Heinecke J, Wink DA. Biological signaling by small inorganic molecules. Coordination Chemistry Reviews. 306: 708-723. PMID 26688591 DOI: 10.1016/J.Ccr.2015.06.001  0.723
2016 Glynn S, Garrrido-Cuesta P, Wink D, Ridnour L, Ambs S, Keane M, Walsh E, Callagy G. Abstract P2-05-15: NOS2&COX2 activation of TLR4 & EGFR signalling causes poor outcome in oestrogen receptor-negative breast cancer via pro-survival signals and immune polarisation Cancer Research. 76. DOI: 10.1158/1538-7445.Sabcs15-P2-05-15  0.384
2015 Wink DA, Ridnour LA, Cheng R, Switzer CW, Glynn S, Ambs S. The Oncogenic Properties Of The Redox Inflammatory Protein Inducible Nitric Oxide Synthase In ER(-) Breast Cancer. Redox Biology. 5: 413. PMID 28162269 DOI: 10.1016/J.Redox.2015.09.012  0.477
2015 Miller TW, Soto-Pantoja DR, Schwartz AL, Sipes JM, DeGraff WG, Ridnour LA, Wink DA, Roberts DD. CD47 Globally Regulates Metabolic Pathways that Control Resistance to Ionizing Radiation. The Journal of Biological Chemistry. PMID 26311851 DOI: 10.1074/Jbc.M115.665752  0.315
2015 Thomas DD, Heinecke JL, Ridnour LA, Cheng RY, Kesarwala AH, Switzer CH, McVicar DW, Roberts DD, Glynn S, Fukuto JM, Wink DA, Miranda KM. Signaling and stress: The redox landscape in NOS2 biology. Free Radical Biology & Medicine. 87: 204-225. PMID 26117324 DOI: 10.1016/J.Freeradbiomed.2015.06.002  0.323
2015 Ridnour LA, Cheng RY, Weiss JM, Kaur S, Soto-Pantoja DR, Basudhar D, Heinecke JL, Stewart CA, DeGraff W, Sowers AL, Thetford A, Kesarwala AH, Roberts DD, Young HA, Mitchell JB, ... ... Wink DA, et al. NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay. Cancer Research. 75: 2788-99. PMID 25990221 DOI: 10.1158/0008-5472.Can-14-3011  0.73
2015 Basudhar D, Cheng RC, Bharadwaj G, Ridnour LA, Wink DA, Miranda KM. Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast cancer. Free Radical Biology & Medicine. 83: 101-14. PMID 25659932 DOI: 10.1016/J.Freeradbiomed.2015.01.029  0.763
2015 Moody TW, Jensen RT, Thomas K, Fairfull-Smith KE, Bottle SE, Ridnour L, Wink DA. Abstract 4539: Nitroxide-aspirin conjugates: A new class of NSAIDs Cancer Research. 75: 4539-4539. DOI: 10.1158/1538-7445.Am2015-4539  0.339
2015 Fujita M, Imadome K, Shoji Y, Cheng R, Kesarwala AH, Wink DA, Imai T. Abstract 4140: Role of nitric oxide in invasiveness of tumor cells irradiated with carbon-ion beams Cancer Research. 75: 4140-4140. DOI: 10.1158/1538-7445.Am2015-4140  0.323
2015 Basudhar D, Cheng RC, Bharadwaj G, Ridnour LA, Wink DA, Miranda KM. Chemotherapeutic potential of diazeniumdiolate-based aspirin prodrugs in breast cancer Free Radical Biology and Medicine. 83: 101-114. DOI: 10.1016/j.freeradbiomed.2015.01.029  0.708
2014 Hoos MD, Vitek MP, Ridnour LA, Wilson J, Jansen M, Everhart A, Wink DA, Colton CA. The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment. Molecular Neurodegeneration. 9: 50. PMID 25403885 DOI: 10.1186/1750-1326-9-50  0.314
2014 Srinivas P, Wink D, Mohanakumar KP, Pillai MR. The legacy of nitric oxide: Impact on disease biology Nitric Oxide - Biology and Chemistry. 43: 1-2. PMID 25239656 DOI: 10.1016/J.Niox.2014.09.005  0.365
2014 Cheng RY, Basudhar D, Ridnour LA, Heinecke JL, Kesarwala AH, Glynn S, Switzer CH, Ambs S, Miranda KM, Wink DA. Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 43: 17-28. PMID 25153034 DOI: 10.1016/J.Niox.2014.08.003  0.77
2014 Samuni Y, Wink DA, Krishna MC, Mitchell JB, Goldstein S. Suberoylanilide hydroxamic acid radiosensitizes tumor hypoxic cells in vitro through the oxidation of nitroxyl to nitric oxide. Free Radical Biology & Medicine. 73: 291-8. PMID 24880052 DOI: 10.1016/J.Freeradbiomed.2014.05.019  0.429
2014 Miranda KM, Wink DA. Persulfides and the cellular thiol landscape. Proceedings of the National Academy of Sciences of the United States of America. 111: 7505-6. PMID 24828533 DOI: 10.1073/Pnas.1405665111  0.364
2014 Heinecke JL, Ridnour LA, Cheng RY, Switzer CH, Lizardo MM, Khanna C, Glynn SA, Hussain SP, Young HA, Ambs S, Wink DA. Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 111: 6323-8. PMID 24733928 DOI: 10.1073/Pnas.1401799111  0.467
2014 Ridnour L, Glynn S, Barasch K, Windhausen A, Sneha D, Dorsey T, Yfantis H, Lee DH, Heinecke J, Brueggemann E, Lizardo M, Khanna C, Ambs S, Wink D, Hines H, et al. Nitric oxide and breast cancer disease progression: Role of timp-1 in pro-survival signaling Nitric Oxide. 42: 139-140. DOI: 10.1016/J.Niox.2014.09.120  0.427
2014 Cheng R, Debashree B, Ridnour L, Wink D, Miranda K. Differentiating nitric oxide and nitroxyl associated gene expressions as their relates to cancer and treatment Nitric Oxide. 42: 117-118. DOI: 10.1016/J.Niox.2014.09.058  0.383
2014 Miranda K, Debashree B, Cheng R, Bharadwaj G, Ridnour L, Wink D. Nitrogen oxide releasing NSAIDs as anticancer agents Nitric Oxide. 42: 110-111. DOI: 10.1016/J.Niox.2014.09.038  0.35
2013 Basudhar D, Bharadwaj G, Cheng RY, Jain S, Shi S, Heinecke JL, Holland RJ, Ridnour LA, Caceres VM, Spadari-Bratfisch RC, Paolocci N, Velázquez-Martínez CA, Wink DA, Miranda KM. Synthesis and chemical and biological comparison of nitroxyl- and nitric oxide-releasing diazeniumdiolate-based aspirin derivatives. Journal of Medicinal Chemistry. 56: 7804-20. PMID 24102516 DOI: 10.1021/Jm400196Q  0.731
2013 Heinrich TA, da Silva RS, Miranda KM, Switzer CH, Wink DA, Fukuto JM. Biological nitric oxide signalling: chemistry and terminology. British Journal of Pharmacology. 169: 1417-29. PMID 23617570 DOI: 10.1111/Bph.12217  0.374
2013 Ridnour LA, Cheng RY, Switzer CH, Heinecke JL, Ambs S, Glynn S, Young HA, Trinchieri G, Wink DA. Molecular pathways: toll-like receptors in the tumor microenvironment--poor prognosis or new therapeutic opportunity. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 1340-6. PMID 23271799 DOI: 10.1158/1078-0432.Ccr-12-0408  0.404
2013 Chavis JT, Neal J, Switzer C, Wink DA, Garcin ED. Determining the Effect of Dithiolethione Compounds on the Activity of Human Glyceraldehyde-3-Phosphate Dehydrogenase Biophysical Journal. 104: 232a. DOI: 10.1016/J.Bpj.2012.11.1308  0.353
2012 Switzer CH, Ridnour LA, Cheng R, Heinecke J, Burke A, Glynn S, Ambs S, Wink DA. S-Nitrosation Mediates Multiple Pathways That Lead to Tumor Progression in Estrogen Receptor-Negative Breast Cancer. Forum On Immunopathological Diseases and Therapeutics. 3: 117-124. PMID 23543871 DOI: 10.1615/Forumimmundisther.2012006108  0.426
2012 Switzer CH, Cheng RY, Ridnour LA, Glynn SA, Ambs S, Wink DA. Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer. Breast Cancer Research : Bcr. 14: R125. PMID 22971289 DOI: 10.1186/Bcr3319  0.413
2012 Sohn JJ, Schetter AJ, Yfantis HG, Ridnour LA, Horikawa I, Khan MA, Robles AI, Hussain SP, Goto A, Bowman ED, Hofseth LJ, Bartkova J, Bartek J, Wogan GN, Wink DA, et al. Macrophages, nitric oxide and microRNAs are associated with DNA damage response pathway and senescence in inflammatory bowel disease. Plos One. 7: e44156. PMID 22970173 DOI: 10.1371/Journal.Pone.0044156  0.363
2012 Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH, Cheng RY, Heinecke JL, Brueggemann E, Hines HB, Khanna C, Glynn SA, Ambs S, ... Wink DA, et al. Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation. Plos One. 7: e44081. PMID 22957045 DOI: 10.1371/Journal.Pone.0044081  0.409
2012 Switzer CH, Glynn SA, Cheng RY, Ridnour LA, Green JE, Ambs S, Wink DA. S-nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer. Molecular Cancer Research : McR. 10: 1203-15. PMID 22878588 DOI: 10.1158/1541-7786.Mcr-12-0124  0.414
2012 Gao WD, Murray CI, Tian Y, Zhong X, DuMond JF, Shen X, Stanley BA, Foster DB, Wink DA, King SB, Van Eyk JE, Paolocci N. Nitroxyl-mediated disulfide bond formation between cardiac myofilament cysteines enhances contractile function. Circulation Research. 111: 1002-11. PMID 22851540 DOI: 10.1161/Circresaha.112.270827  0.312
2012 Schoenfeld MP, Ansari RR, Nakao A, Wink D. A hypothesis on biological protection from space radiation through the use of new therapeutic gases as medical counter measures. Medical Gas Research. 2: 8. PMID 22475015 DOI: 10.1186/2045-9912-2-8  0.33
2012 Switzer CH, Cheng RY, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB, Glynn SA, Ambs S, Wink DA. Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer. Cancer Research. 72: 2394-404. PMID 22436383 DOI: 10.1158/0008-5472.Can-11-3115  0.398
2012 Moody TW, Osefo N, Nuche-Berenguer B, Ridnour L, Wink D, Jensen RT. Pituitary adenylate cyclase-activating polypeptide causes tyrosine phosphorylation of the epidermal growth factor receptor in lung cancer cells. The Journal of Pharmacology and Experimental Therapeutics. 341: 873-81. PMID 22389426 DOI: 10.1124/Jpet.111.190033  0.301
2012 Horváth B, Mukhopadhyay P, Kechrid M, Patel V, Tanchian G, Wink DA, Gertsch J, Pacher P. β-Caryophyllene ameliorates cisplatin-induced nephrotoxicity in a cannabinoid 2 receptor-dependent manner. Free Radical Biology & Medicine. 52: 1325-33. PMID 22326488 DOI: 10.1016/J.Freeradbiomed.2012.01.014  0.361
2012 Fukuto JM, Carrington SJ, Tantillo DJ, Harrison JG, Ignarro LJ, Freeman BA, Chen A, Wink DA. Small molecule signaling agents: The integrated chemistry and biochemistry of nitrogen oxides, oxides of carbon, dioxygen, hydrogen sulfide, and their derived species Chemical Research in Toxicology. 25: 769-793. PMID 22263838 DOI: 10.1021/Tx2005234  0.322
2012 Flores-Santana W, Moody T, Chen W, Gorczynski MJ, Shoman ME, Velázquez C, Thetford A, Mitchell JB, Cherukuri MK, King SB, Wink DA. Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells. British Journal of Pharmacology. 165: 1058-67. PMID 21658022 DOI: 10.1111/J.1476-5381.2011.01527.X  0.335
2012 Moody TW, Mantey S, Jensen RT, Wink D, Mukhopadhyay P, Pacher P. Abstract 1091: Cannabinoids inhibit epidermal growth factor receptor transactivation in lung cancer cells Cancer Research. 72: 1091-1091. DOI: 10.1158/1538-7445.Am2012-1091  0.32
2011 Switzer CH, Glynn SA, Ridnour LA, Cheng RY, Vitek MP, Ambs S, Wink DA. Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer. Trends in Pharmacological Sciences. 32: 644-51. PMID 21893353 DOI: 10.1016/J.Tips.2011.07.001  0.432
2011 Mukhopadhyay P, Rajesh M, Horváth B, Bátkai S, Park O, Tanchian G, Gao RY, Patel V, Wink DA, Liaudet L, Haskó G, Mechoulam R, Pacher P. Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death Free Radical Biology and Medicine. 50: 1368-1381. PMID 21362471 DOI: 10.1016/J.Freeradbiomed.2011.02.021  0.351
2011 Switzer CH, Cheng RY, Vitek TM, Christensen DJ, Wink DA, Vitek MP. Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy. Oncogene. 30: 2504-13. PMID 21297667 DOI: 10.1038/Onc.2010.622  0.365
2011 Tocchetti CG, Stanley BA, Murray CI, Sivakumaran V, Donzelli S, Mancardi D, Pagliaro P, Gao WD, van Eyk J, Kass DA, Wink DA, Paolocci N. Playing with cardiac "redox switches": the "HNO way" to modulate cardiac function. Antioxidants & Redox Signaling. 14: 1687-98. PMID 21235349 DOI: 10.1089/Ars.2010.3859  0.303
2011 Flores-Santana W, Salmon DJ, Donzelli S, Switzer CH, Basudhar D, Ridnour L, Cheng R, Glynn SA, Paolocci N, Fukuto JM, Miranda KM, Wink DA. The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems. Antioxidants & Redox Signaling. 14: 1659-74. PMID 21235346 DOI: 10.1089/Ars.2010.3841  0.739
2011 Wink DA, Hines HB, Cheng RY, Switzer CH, Flores-Santana W, Vitek MP, Ridnour LA, Colton CA. Nitric oxide and redox mechanisms in the immune response. Journal of Leukocyte Biology. 89: 873-91. PMID 21233414 DOI: 10.1189/Jlb.1010550  0.364
2011 Schoenfeld MP, Ansari RR, Zakrajsek JF, Billiar TR, Toyoda Y, Wink DA, Nakao A. Hydrogen therapy may reduce the risks related to radiation-induced oxidative stress in space flight. Medical Hypotheses. 76: 117-8. PMID 20851533 DOI: 10.1016/J.Mehy.2010.08.046  0.33
2010 Rajesh M, Mukhopadhyay P, Bátkai S, Patel V, Saito K, Matsumoto S, Kashiwaya Y, Horváth B, Mukhopadhyay B, Becker L, Haskó G, Liaudet L, Wink DA, Veves A, Mechoulam R, et al. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. Journal of the American College of Cardiology. 56: 2115-25. PMID 21144973 DOI: 10.1016/J.Jacc.2010.07.033  0.329
2010 Glynn SA, Prueitt RL, Ridnour LA, Boersma BJ, Dorsey TM, Wink DA, Goodman JE, Yfantis HG, Lee DH, Ambs S. COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer. Bmc Cancer. 10: 626. PMID 21078168 DOI: 10.1186/1471-2407-10-626  0.378
2010 Andrei D, Salmon DJ, Donzelli S, Wahab A, Klose JR, Citro ML, Saavedra JE, Wink DA, Miranda KM, Keefer LK. Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class. Journal of the American Chemical Society. 132: 16526-32. PMID 21033665 DOI: 10.1021/Ja106552P  0.322
2010 Glynn SA, Boersma BJ, Dorsey TH, Yi M, Yfantis HG, Ridnour LA, Martin DN, Switzer CH, Hudson RS, Wink DA, Lee DH, Stephens RM, Ambs S. Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients. The Journal of Clinical Investigation. 120: 3843-54. PMID 20978357 DOI: 10.1172/Jci42059  0.425
2010 Weiss JM, Ridnour LA, Back T, Hussain SP, He P, Maciag AE, Keefer LK, Murphy WJ, Harris CC, Wink DA, Wiltrout RH. Macrophage-dependent nitric oxide expression regulates tumor cell detachment and metastasis after IL-2/anti-CD40 immunotherapy. The Journal of Experimental Medicine. 207: 2455-67. PMID 20921282 DOI: 10.1084/Jem.20100670  0.338
2010 Jourd'heuil D, Lancaster JR, Fukuto J, Roberts DD, Miranda KM, Mayer B, Grisham MB, Wink DA. The bell-shaped curve for peroxynitrite-mediated oxidation and nitration of NO/O2-* is alive and well. The Journal of Biological Chemistry. 285: le15; author reply l. PMID 20729216 DOI: 10.1074/Jbc.L110.110080  0.396
2010 Moody TW, Switzer C, Santana-Flores W, Ridnour LA, Berna M, Thill M, Jensen RT, Sparatore A, Del Soldato P, Yeh GC, Roberts DD, Giaccone G, Wink DA. Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells. Lung Cancer (Amsterdam, Netherlands). 68: 154-60. PMID 19628293 DOI: 10.1016/J.Lungcan.2009.06.012  0.309
2010 Weiss JM, Ridnour L, Hussein P, He P, Back TC, Scarzello T, Maciag AE, Keefer L, Murphy WJ, Harris CC, Wink DA, Wiltrout RH. Abstract 5594: Immunotherapy of metastastic renal cell carcinoma reveals a critical role for nitric oxide expression in the control of lung metastases but not primary tumors Cancer Research. 70: 5594-5594. DOI: 10.1158/1538-7445.Am10-5594  0.347
2010 Cheng R, Glynn S, Flores-Santana W, Switzer C, Ridnour L, Wink DA. Chapter 5 – Nitric Oxide and Redox Inflammation in Cancer Advances in Molecular Toxicology. 4: 157-182. DOI: 10.1016/S1872-0854(10)04005-1  0.458
2010 Samuni Y, Flores-Santana W, Krishna MC, Mitchell JB, Wink DA. Corrigendum to “The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation” [Free Radic. Biol. Med. 47/4 (2009) 419–423] Free Radical Biology and Medicine. 48: 372. DOI: 10.1016/J.Freeradbiomed.2009.10.001  0.37
2010 Thomas DD, Flores-Santana W, Switzer CH, Wink DA, Ridnour LA. Determinants of Nitric Oxide Chemistry. Impact of Cell Signaling Processes. Nitric Oxide. 3-25. DOI: 10.1016/B978-0-12-373866-0.00001-0  0.373
2009 Flores-Santana W, Switzer C, Ridnour LA, Basudhar D, Mancardi D, Donzelli S, Thomas DD, Miranda KM, Fukuto JM, Wink DA. Comparing the chemical biology of NO and HNO. Archives of Pharmacal Research. 32: 1139-53. PMID 19727606 DOI: 10.1007/S12272-009-1805-X  0.727
2009 Switzer CH, Ridnour LA, Cheng RY, Sparatore A, Del Soldato P, Moody TW, Vitek MP, Roberts DD, Wink DA. Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity. Oncogene. 28: 3837-46. PMID 19701246 DOI: 10.1038/Onc.2009.244  0.349
2009 Jackson MI, Han TH, Serbulea L, Dutton A, Ford E, Miranda KM, Houk KN, Wink DA, Fukuto JM. Kinetic feasibility of nitroxyl reduction by physiological reductants and biological implications. Free Radical Biology & Medicine. 47: 1130-9. PMID 19577638 DOI: 10.1016/J.Freeradbiomed.2009.06.034  0.397
2009 MacDonald CJ, Cheng RY, Roberts DD, Wink DA, Yeh GC. Modulation of carcinogen metabolism by nitric oxide-aspirin 2 is associated with suppression of DNA damage and DNA adduct formation. The Journal of Biological Chemistry. 284: 22099-107. PMID 19542225 DOI: 10.1074/Jbc.M109.021063  0.331
2009 Glynn SA, Boersma BJ, Howe TM, Edvardsen H, Geisler SB, Goodman JE, Ridnour LA, Lønning PE, Børresen-Dale AL, Naume B, Kristensen VN, Chanock SJ, Wink DA, Ambs S. A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 4165-73. PMID 19509150 DOI: 10.1158/1078-0432.Ccr-09-0119  0.348
2009 Samuni Y, Flores-Santana W, Krishna MC, Mitchell JB, Wink DA. The inhibitors of histone deacetylase suberoylanilide hydroxamate and trichostatin A release nitric oxide upon oxidation. Free Radical Biology & Medicine. 47: 419-23. PMID 19447172 DOI: 10.1016/J.Freeradbiomed.2009.05.011  0.391
2009 Switzer CH, Flores-Santana W, Mancardi D, Donzelli S, Basudhar D, Ridnour LA, Miranda KM, Fukuto JM, Paolocci N, Wink DA. The emergence of nitroxyl (HNO) as a pharmacological agent. Biochimica Et Biophysica Acta. 1787: 835-40. PMID 19426703 DOI: 10.1016/J.Bbabio.2009.04.015  0.757
2009 Paolocci N, Wink DA. The shy Angeli and his elusive creature: the HNO route to vasodilation. American Journal of Physiology. Heart and Circulatory Physiology. 296: H1217-20. PMID 19286958 DOI: 10.1152/Ajpheart.00243.2009  0.343
2009 Mancardi D, Penna C, Merlino A, Del Soldato P, Wink DA, Pagliaro P. Physiological and pharmacological features of the novel gasotransmitter: hydrogen sulfide. Biochimica Et Biophysica Acta. 1787: 864-72. PMID 19285949 DOI: 10.1016/J.Bbabio.2009.03.005  0.303
2009 Bass SE, Sienkiewicz P, Macdonald CJ, Cheng RY, Sparatore A, Del Soldato P, Roberts DD, Moody TW, Wink DA, Yeh GC. Novel dithiolethione-modified nonsteroidal anti-inflammatory drugs in human hepatoma HepG2 and colon LS180 cells. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 1964-72. PMID 19276279 DOI: 10.1158/1078-0432.Ccr-08-1870  0.325
2009 Glynn S, Boersma B, Howe T, Ridnour L, Wink D, Edvardsen H, Børresen-Dale A, Ambs S. A functional SNP in the leader sequence of the manganese superoxide dimutase gene is a predictor of breast cancer patient survival and response to chemotherapy. Cancer Research. 69: 6067. DOI: 10.1158/0008-5472.Sabcs-6067  0.316
2009 Glynn S, Boersma B, Howe T, Ridnour L, Wink D, Yi M, Yvantis H, Ambs S. Aberrant inducible nitric oxide synthase expression predicts poor survival in estrogen receptor negative breast cancer, and is associated with a gene expression signature similar to that of basal-like breast cancer. Cancer Research. 69: 5067. DOI: 10.1158/0008-5472.Sabcs-5067  0.409
2008 Isenberg JS, Frazier WA, Krishna MC, Wink DA, Roberts DD. Enhancing cardiovascular dynamics by inhibition of thrombospondin-1/CD47 signaling. Current Drug Targets. 9: 833-41. PMID 18855617 DOI: 10.2174/138945008785909338  0.323
2008 Isenberg JS, Maxhimer JB, Hyodo F, Pendrak ML, Ridnour LA, DeGraff WG, Tsokos M, Wink DA, Roberts DD. Thrombospondin-1 and CD47 limit cell and tissue survival of radiation injury. The American Journal of Pathology. 173: 1100-12. PMID 18787106 DOI: 10.2353/Ajpath.2008.080237  0.302
2008 Martin-Manso G, Galli S, Ridnour LA, Tsokos M, Wink DA, Roberts DD. Thrombospondin 1 promotes tumor macrophage recruitment and enhances tumor cell cytotoxicity of differentiated U937 cells. Cancer Research. 68: 7090-9. PMID 18757424 DOI: 10.1158/0008-5472.Can-08-0643  0.4
2008 Isenberg JS, Hyodo F, Ridnour LA, Shannon CS, Wink DA, Krishna MC, Roberts DD. Thrombospondin 1 and vasoactive agents indirectly alter tumor blood flow. Neoplasia (New York, N.Y.). 10: 886-96. PMID 18670646 DOI: 10.1593/Neo.08264  0.366
2008 Wink DA, Ridnour LA, Hussain SP, Harris CC. The reemergence of nitric oxide and cancer. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 19: 65-7. PMID 18638716 DOI: 10.1016/J.Niox.2008.05.003  0.401
2008 Donzelli S, Espey MG, Flores-Santana W, Switzer CH, Yeh GC, Huang J, Stuehr DJ, King SB, Miranda KM, Wink DA. Generation of nitroxyl by heme protein-mediated peroxidation of hydroxylamine but not N-hydroxy-L-arginine. Free Radical Biology & Medicine. 45: 578-84. PMID 18503778 DOI: 10.1016/J.Freeradbiomed.2008.04.036  0.402
2008 Ridnour LA, Thomas DD, Switzer C, Flores-Santana W, Isenberg JS, Ambs S, Roberts DD, Wink DA. Molecular mechanisms for discrete nitric oxide levels in cancer. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 19: 73-6. PMID 18472020 DOI: 10.1016/J.Niox.2008.04.006  0.486
2008 Thomas DD, Ridnour LA, Isenberg JS, Flores-Santana W, Switzer CH, Donzelli S, Hussain P, Vecoli C, Paolocci N, Ambs S, Colton CA, Harris CC, Roberts DD, Wink DA. The chemical biology of nitric oxide: implications in cellular signaling. Free Radical Biology & Medicine. 45: 18-31. PMID 18439435 DOI: 10.1016/J.Freeradbiomed.2008.03.020  0.403
2007 Lopez BE, Wink DA, Fukuto JM. The inhibition of glyceraldehyde-3-phosphate dehydrogenase by nitroxyl (HNO). Archives of Biochemistry and Biophysics. 465: 430-6. PMID 17678614 DOI: 10.1016/J.Abb.2007.06.017  0.361
2007 Roberts DD, Isenberg JS, Ridnour LA, Wink DA. Nitric oxide and its gatekeeper thrombospondin-1 in tumor angiogenesis. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 13: 795-8. PMID 17289869 DOI: 10.1158/1078-0432.Ccr-06-1758  0.394
2007 Prueitt RL, Boersma BJ, Howe TM, Goodman JE, Thomas DD, Ying L, Pfiester CM, Yfantis HG, Cottrell JR, Lee DH, Remaley AT, Hofseth LJ, Wink DA, Ambs S. Inflammation and IGF-I activate the Akt pathway in breast cancer. International Journal of Cancer. 120: 796-805. PMID 17096325 DOI: 10.1002/Ijc.22336  0.395
2007 Glynn S, Boersma B, Martin D, Howe T, Ridnour L, Wink D, Yi M, Stephens R, Yfantis H, Ambs S. B5. iNOS expression is associated with basal-like breast cancer phenotype and predicts poor survival in ERneg breast cancer Nitric Oxide. 17: 17. DOI: 10.1016/J.Niox.2007.09.038  0.34
2006 Thomas DD, Espey MG, Pociask DA, Ridnour LA, Donzelli S, Wink DA. Asbestos redirects nitric oxide signaling through rapid catalytic conversion to nitrite. Cancer Research. 66: 11600-4. PMID 17178853 DOI: 10.1158/0008-5472.Can-06-1140  0.417
2006 Donzelli S, Switzer CH, Thomas DD, Ridnour LA, Espey MG, Isenberg JS, Tocchetti CG, King SB, Lazzarino G, Miranda KM, Roberts DD, Feelisch M, Wink DA. The activation of metabolites of nitric oxide synthase by metals is both redox and oxygen dependent: a new feature of nitrogen oxide signaling. Antioxidants & Redox Signaling. 8: 1363-71. PMID 16910783 DOI: 10.1089/Ars.2006.8.1363  0.383
2006 Ridnour LA, Thomas DD, Donzelli S, Espey MG, Roberts DD, Wink DA, Isenberg JS. The biphasic nature of nitric oxide responses in tumor biology. Antioxidants & Redox Signaling. 8: 1329-37. PMID 16910780 DOI: 10.1089/Ars.2006.8.1329  0.458
2006 Thomas DD, Ridnour LA, Espey MG, Donzelli S, Ambs S, Hussain SP, Harris CC, DeGraff W, Roberts DD, Mitchell JB, Wink DA. Superoxide fluxes limit nitric oxide-induced signaling. The Journal of Biological Chemistry. 281: 25984-93. PMID 16829532 DOI: 10.1074/Jbc.M602242200  0.372
2006 Isenberg JS, Wink DA, Roberts DD. Thrombospondin-1 antagonizes nitric oxide-stimulated vascular smooth muscle cell responses. Cardiovascular Research. 71: 785-93. PMID 16820142 DOI: 10.1016/J.Cardiores.2006.05.024  0.335
2006 Donzelli S, Espey MG, Thomas DD, Mancardi D, Tocchetti CG, Ridnour LA, Paolocci N, King SB, Miranda KM, Lazzarino G, Fukuto JM, Wink DA. Discriminating formation of HNO from other reactive nitrogen oxide species. Free Radical Biology & Medicine. 40: 1056-66. PMID 16540401 DOI: 10.1016/J.Freeradbiomed.2005.10.058  0.403
2006 Isenberg JS, Ridnour LA, Thomas DD, Wink DA, Roberts DD, Espey MG. Guanylyl cyclase-dependent chemotaxis of endothelial cells in response to nitric oxide gradients. Free Radical Biology & Medicine. 40: 1028-33. PMID 16540398 DOI: 10.1016/J.Freeradbiomed.2005.10.053  0.387
2006 Switzer CH, Ridnour L, Isenberg J, Roberts D, Wink D. P115. The role of NO, HNO and H2S on NSAID-based cancer therapeutics Nitric Oxide. 14: 54. DOI: 10.1016/J.Niox.2006.04.181  0.307
2006 Donzelli S, Switzer CH, Espey MG, Thomas DD, Ridnour LA, Miranda KM, Tocchetti CG, Lazzarino G, Paolocci N, Wink DA. P044. Nitroxyl formation from NH2OH and NOHA oxidation Nitric Oxide. 14: 32. DOI: 10.1016/J.Niox.2006.04.105  0.344
2006 Thomas DD, Ridnour L, Eepey MG, Roberts D, Mitchell JB, Wink DA. P036. Superoxide fluxes limit nitric oxide-induced signaling Nitric Oxide. 14: 29-30. DOI: 10.1016/J.Niox.2006.04.097  0.372
2006 Espey MG, Wink D. O43. Nitrite reduction is an innate survival adaptation of cancer cells to hypoxia Nitric Oxide. 14: 13-14. DOI: 10.1016/J.Niox.2006.04.047  0.321
2006 Colton C, Wink D, Weinberg JB, Nostrand WV, Dawson H, Vitek M. O29. Nitric oxide is neuroprotective in a mouse model of Aβ-mediated chronic neurodegeneration Nitric Oxide. 14: 9. DOI: 10.1016/J.Niox.2006.04.033  0.338
2005 Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR, Feelisch M, et al. The emerging biology of the nitrite anion. Nature Chemical Biology. 1: 308-14. PMID 16408064 DOI: 10.1038/Nchembio1105-308  0.339
2005 Miranda KM, Katori T, Torres de Holding CL, Thomas L, Ridnour LA, McLendon WJ, Cologna SM, Dutton AS, Champion HC, Mancardi D, Tocchetti CG, Saavedra JE, Keefer LK, Houk KN, Fukuto JM, ... ... Wink DA, et al. Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo. Journal of Medicinal Chemistry. 48: 8220-8. PMID 16366603 DOI: 10.1021/Jm050151I  0.335
2005 Hewett SJ, Espey MG, Uliasz TF, Wink DA. Neurotoxicity of nitroxyl: insights into HNO and NO biochemical imbalance. Free Radical Biology & Medicine. 39: 1478-88. PMID 16274883 DOI: 10.1016/J.Freeradbiomed.2005.07.007  0.351
2005 Isenberg JS, Ridnour LA, Perruccio EM, Espey MG, Wink DA, Roberts DD. Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 102: 13141-6. PMID 16150726 DOI: 10.1073/Pnas.0502977102  0.348
2005 Ridnour LA, Isenberg JS, Espey MG, Thomas DD, Roberts DD, Wink DA. Nitric oxide regulates angiogenesis through a functional switch involving thrombospondin-1. Proceedings of the National Academy of Sciences of the United States of America. 102: 13147-52. PMID 16141331 DOI: 10.1073/Pnas.0502979102  0.362
2005 Isenberg JS, Ridnour LA, Espey MG, Wink DA, Roberts DD. Nitric oxide in wound-healing. Microsurgery. 25: 442-51. PMID 16044466 DOI: 10.1002/Micr.20168  0.36
2005 Fukuto JM, Bartberger MD, Dutton AS, Paolocci N, Wink DA, Houk KN. The physiological chemistry and biological activity of nitroxyl (HNO): the neglected, misunderstood, and enigmatic nitrogen oxide. Chemical Research in Toxicology. 18: 790-801. PMID 15892572 DOI: 10.1021/Tx0496800  0.388
2005 Fukuto JM, Switzer CH, Miranda KM, Wink DA. Nitroxyl (HNO): chemistry, biochemistry, and pharmacology. Annual Review of Pharmacology and Toxicology. 45: 335-55. PMID 15822180 DOI: 10.1146/Annurev.Pharmtox.45.120403.095959  0.337
2004 Cook JA, Gius D, Wink DA, Krishna MC, Russo A, Mitchell JB. Oxidative stress, redox, and the tumor microenvironment. Seminars in Radiation Oncology. 14: 259-66. PMID 15254869 DOI: 10.1016/J.Semradonc.2004.04.001  0.432
2004 Xu Q, Wink DA, Colton CA. Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. Experimental Neurology. 188: 341-50. PMID 15246834 DOI: 10.1016/J.Expneurol.2004.04.016  0.34
2004 Thomas DD, Espey MG, Ridnour LA, Hofseth LJ, Mancardi D, Harris CC, Wink DA. Hypoxic inducible factor 1alpha, extracellular signal-regulated kinase, and p53 are regulated by distinct threshold concentrations of nitric oxide. Proceedings of the National Academy of Sciences of the United States of America. 101: 8894-9. PMID 15178764 DOI: 10.1073/Pnas.0400453101  0.355
2004 Ridnour LA, Thomas DD, Mancardi D, Espey MG, Miranda KM, Paolocci N, Feelisch M, Fukuto J, Wink DA. The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations. Biological Chemistry. 385: 1-10. PMID 14977040 DOI: 10.1515/Bc.2004.001  0.369
2004 Ridnour LA, Thomas DD, Mancardi D, Donzelli S, Paolocci N, Pagliaro P, Miranda KM, Krishna M, Fukuto J, Grisham MB, Mitchell JB, Espey MG, Wink DA. Antioxidant properties of nitric oxide in cellular physiological and pathophysiological mechanisms. The implications of biological balance between NO and oxidative stress Current Medicinal Chemistry: Anti-Inflammatory and Anti-Allergy Agents. 3: 181-188. DOI: 10.2174/1568014043355311  0.412
2004 Katori T, Tocchetti CG, Miranda KM, Champion HC, Fukuto JM, Wink DA, Kass DA, Paolocci N. 1144-104 The novel organic nitroxyl donor, isopropylamine/nitric oxide exerts beta-independent positive inotropy/lusitropy in failing hearts Journal of the American College of Cardiology. 43: A218. DOI: 10.1016/S0735-1097(04)90925-4  0.31
2004 Tocchetti CG, Katori T, Zaccolo M, Mancardi D, Belardi DF, Miranda KM, Wink DA, Kass DA, Paolocci N. 1011-110 The HNO/nitric oxide donor Angeli's salt enhances myocyte contractility in a PKA-dependent manner Journal of the American College of Cardiology. 43: A156. DOI: 10.1016/S0735-1097(04)90661-4  0.37
2003 Sidorkina O, Espey MG, Miranda KM, Wink DA, Laval J. Inhibition of poly(ADP-RIBOSE) polymerase (PARP) by nitric oxide and reactive nitrogen oxide species. Free Radical Biology & Medicine. 35: 1431-8. PMID 14642390 DOI: 10.1016/J.Freeradbiomed.2003.08.015  0.439
2003 Thomas DD, Miranda KM, Colton CA, Citrin D, Espey MG, Wink DA. Heme proteins and nitric oxide (NO): the neglected, eloquent chemistry in NO redox signaling and regulation. Antioxidants & Redox Signaling. 5: 307-17. PMID 12880485 DOI: 10.1089/152308603322110887  0.397
2003 Wink DA, Miranda KM, Katori T, Mancardi D, Thomas DD, Ridnour L, Espey MG, Feelisch M, Colton CA, Fukuto JM, Pagliaro P, Kass DA, Paolocci N. Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm. American Journal of Physiology. Heart and Circulatory Physiology. 285: H2264-76. PMID 12855429 DOI: 10.1152/Ajpheart.00531.2003  0.422
2003 Wink DA, Mitchell JB. Nitric oxide and cancer: an introduction. Free Radical Biology & Medicine. 34: 951-4. PMID 12684080 DOI: 10.1016/S0891-5849(02)01362-X  0.436
2003 Miranda KM, Nims RW, Thomas DD, Espey MG, Citrin D, Bartberger MD, Paolocci N, Fukuto JM, Feelisch M, Wink DA. Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS. Journal of Inorganic Biochemistry. 93: 52-60. PMID 12538052 DOI: 10.1016/S0162-0134(02)00498-1  0.416
2003 Hofseth LJ, Saito S, Hussain SP, Espey MG, Miranda KM, Araki Y, Jhappan C, Higashimoto Y, He P, Linke SP, Quezado MM, Zurer I, Rotter V, Wink DA, Appella E, et al. Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proceedings of the National Academy of Sciences of the United States of America. 100: 143-8. PMID 12518062 DOI: 10.1073/Pnas.0237083100  0.341
2003 Pagliaro P, Mancardi D, Rastaldo R, Penna C, Gattullo D, Miranda KM, Feelisch M, Wink DA, Kass DA, Paolocci N. Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning. Free Radical Biology & Medicine. 34: 33-43. PMID 12498977 DOI: 10.1016/S0891-5849(02)01179-6  0.307
2003 Miranda KM, Paolocci N, Katori T, Thomas DD, Wink DA. A biochemical rationale for the orthogonal behavior of nitroxyl (HNO) and nitric oxide (NO) in the cardiovascular system Journal of Inorganic Biochemistry. 96: 49. DOI: 10.1016/S0162-0134(03)80487-7  0.351
2002 Thomas DD, Miranda KM, Espey MG, Citrin D, Jourd'heuil D, Paolocci N, Hewett SJ, Colton CA, Grisham MB, Feelisch M, Wink DA. Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems. Methods in Enzymology. 359: 84-105. PMID 12481562 DOI: 10.1016/S0076-6879(02)59174-6  0.35
2002 Thomas DD, Espey MG, Vitek MP, Miranda KM, Wink DA. Protein nitration is mediated by heme and free metals through Fenton-type chemistry: an alternative to the NO/O2- reaction. Proceedings of the National Academy of Sciences of the United States of America. 99: 12691-6. PMID 12226478 DOI: 10.1073/Pnas.202312699  0.301
2002 Espey MG, Miranda KM, Thomas DD, Wink DA. Ingress and reactive chemistry of nitroxyl-derived species within human cells. Free Radical Biology & Medicine. 33: 827-34. PMID 12208370 DOI: 10.1016/S0891-5849(02)00978-4  0.382
2002 Bartberger MD, Liu W, Ford E, Miranda KM, Switzer C, Fukuto JM, Farmer PJ, Wink DA, Houk KN. The reduction potential of nitric oxide (NO) and its importance to NO biochemistry. Proceedings of the National Academy of Sciences of the United States of America. 99: 10958-63. PMID 12177417 DOI: 10.1073/Pnas.162095599  0.344
2002 Espey MG, Thomas DD, Miranda KM, Wink DA. Focusing of nitric oxide mediated nitrosation and oxidative nitrosylation as a consequence of reaction with superoxide. Proceedings of the National Academy of Sciences of the United States of America. 99: 11127-32. PMID 12177414 DOI: 10.1073/Pnas.152157599  0.383
2002 Espey MG, Miranda KM, Thomas DD, Xavier S, Citrin D, Vitek MP, Wink DA. A chemical perspective on the interplay between NO, reactive oxygen species, and reactive nitrogen oxide species. Annals of the New York Academy of Sciences. 962: 195-206. PMID 12076975 DOI: 10.1111/J.1749-6632.2002.Tb04068.X  0.378
2002 Miranda KM, Yamada K, Espey MG, Thomas DD, DeGraff W, Mitchell JB, Krishna MC, Colton CA, Wink DA. Further evidence for distinct reactive intermediates from nitroxyl and peroxynitrite: effects of buffer composition on the chemistry of Angeli's salt and synthetic peroxynitrite. Archives of Biochemistry and Biophysics. 401: 134-44. PMID 12054463 DOI: 10.1016/S0003-9861(02)00031-0  0.363
2002 Espey MG, Xavier S, Thomas DD, Miranda KM, Wink DA. Direct real-time evaluation of nitration with green fluorescent protein in solution and within human cells reveals the impact of nitrogen dioxide vs. peroxynitrite mechanisms. Proceedings of the National Academy of Sciences of the United States of America. 99: 3481-6. PMID 11904413 DOI: 10.1073/Pnas.062604199  0.386
2001 Wink DA, Kim S, Miles A, Jourd'heuil D, Grisham MB. Methods for distinguishing nitrosative and oxidative chemistry of reactive nitrogen oxide species derived from nitric oxide Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. PMID 20957636 DOI: 10.1002/0471140856.Tx1008S03  0.387
2001 Wink DA, Miranda KM, Espey MG. Cytotoxicity related to oxidative and nitrosative stress by nitric oxide. Experimental Biology and Medicine (Maywood, N.J.). 226: 621-3. PMID 11444095 DOI: 10.1177/153537020222600704  0.375
2001 Espey MG, Miranda KM, Thomas DD, Wink DA. Distinction between nitrosating mechanisms within human cells and aqueous solution. The Journal of Biological Chemistry. 276: 30085-91. PMID 11404354 DOI: 10.1074/Jbc.M101723200  0.407
2001 Wink DA, Miranda KM, Espey MG, Pluta RM, Hewett SJ, Colton C, Vitek M, Feelisch M, Grisham MB. Mechanisms of the antioxidant effects of nitric oxide. Antioxidants & Redox Signaling. 3: 203-13. PMID 11396476 DOI: 10.1089/152308601300185179  0.421
2001 Miranda KM, Espey MG, Wink DA. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 5: 62-71. PMID 11178938 DOI: 10.1006/Niox.2000.0319  0.33
2001 Ogawa R, Pacelli R, Espey MG, Miranda KM, Friedman N, Kim SM, Cox G, Mitchell JB, Wink DA, Russo A. Comparison of control of Listeria by nitric oxide redox chemistry from murine macrophages and NO donors: insights into listeriocidal activity of oxidative and nitrosative stress. Free Radical Biology & Medicine. 30: 268-76. PMID 11165873 DOI: 10.1016/S0891-5849(00)00470-6  0.36
2001 Miranda KM, Espey MG, Yamada K, Krishna M, Ludwick N, Kim S, Jourd'heuil D, Grisham MB, Feelisch M, Fukuto JM, Wink DA. Unique oxidative mechanisms for the reactive nitrogen oxide species, nitroxyl anion Journal of Biological Chemistry. 276: 1720-1727. PMID 11042174 DOI: 10.1074/Jbc.M006174200  0.312
2000 Hrinczenko BW, Alayash AI, Wink DA, Gladwin MT, Rodgers GP, Schechter AN. Effect of nitric oxide and nitric oxide donors on red blood cell oxygen transport British Journal of Haematology. 110: 412-419. PMID 10971400 DOI: 10.1046/J.1365-2141.2000.02203.X  0.357
2000 Zhou X, Espey MG, Chen JX, Hofseth LJ, Miranda KM, Hussain SP, Wink DA, Harris CC. Inhibitory effects of nitric oxide and nitrosative stress on dopamine-beta-hydroxylase. The Journal of Biological Chemistry. 275: 21241-6. PMID 10887204 DOI: 10.1074/Jbc.M904498199  0.369
2000 Ridnour LA, Sim JE, Hayward MA, Wink DA, Martin SM, Buettner GR, Spitz DR. A spectrophotometric method for the direct detection and quantitation of nitric oxide, nitrite, and nitrate in cell culture media. Analytical Biochemistry. 281: 223-9. PMID 10870839 DOI: 10.1006/Abio.2000.4583  0.376
2000 Espey MG, Miranda KM, Feelisch M, Fukuto J, Grisham MB, Vitek MP, Wink DA. Mechanisms of cell death governed by the balance between nitrosative and oxidative stress Annals of the New York Academy of Sciences. 899: 209-221. PMID 10863541 DOI: 10.1111/J.1749-6632.2000.Tb06188.X  0.389
2000 McKinney LC, Aquilla EM, Coffin D, Wink DA, Vodovotz Y. Ionizing radiation potentiates the induction of nitric oxide synthase by interferon-gamma and/or lipopolysaccharide in murine macrophage cell lines. Role of tumor necrosis factor-alpha. Annals of the New York Academy of Sciences. 899: 61-8. PMID 10863529 DOI: 10.1111/J.1749-6632.2000.Tb06176.X  0.376
2000 Miranda KM, Espey MG, Wink DA. A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity. Journal of Inorganic Biochemistry. 79: 237-40. PMID 10830872 DOI: 10.1016/S0162-0134(99)00241-X  0.386
2000 Grisham MB, Jourd'heuil D, Wink DA. Chronic inflammation and reactive oxygen and nitrogen metabolism - Implications in DNA damage and mutagenesis Alimentary Pharmacology and Therapeutics, Supplement. 14: 3-9. PMID 10807397 DOI: 10.1046/J.1365-2036.2000.014S1003.X  0.354
2000 Komarov AM, Wink DA, Feelisch M, Schmidt HH. Electron-paramagnetic resonance spectroscopy using N-methyl-D-glucamine dithiocarbamate iron cannot discriminate between nitric oxide and nitroxyl: implications for the detection of reaction products for nitric oxide synthase. Free Radical Biology & Medicine. 28: 739-42. PMID 10754269 DOI: 10.1016/S0891-5849(00)00156-8  0.347
2000 Espey MG, Miranda KM, Pluta RM, Wink DA. Nitrosative capacity of macrophages is dependent on nitric-oxide synthase induction signals. The Journal of Biological Chemistry. 275: 11341-7. PMID 10753947 DOI: 10.1074/Jbc.275.15.11341  0.399
2000 Wink DA, Miranda KM, Espey MG. Effects of oxidative and nitrosative stress in cytotoxicity. Seminars in Perinatology. 24: 20-3. PMID 10709853 DOI: 10.1016/S0146-0005(00)80049-X  0.4
1999 Vodovotz Y, Coffin D, DeLuca AM, McKinney L, Cook JA, Wink D, Mitchell JB. Induction of nitric oxide production in infiltrating leukocytes following in vivo irradiation of tumor-bearing mice. Radiation Oncology Investigations. 7: 86-97. PMID 10333249 DOI: 10.1002/(Sici)1520-6823(1999)7:2<86::Aid-Roi4>3.0.Co;2-L  0.353
1999 Jourd'heuil D, Miranda KM, Kim SM, Espey MG, Vodovotz Y, Laroux S, Mai CT, Miles AM, Grisham MB, Wink DA. The oxidative and nitrosative chemistry of the nitric oxide/superoxide reaction in the presence of bicarbonate. Archives of Biochemistry and Biophysics. 365: 92-100. PMID 10222043 DOI: 10.1006/Abbi.1999.1143  0.408
1999 Vidwans AS, Kim S, Coffin DO, Wink DA, Hewett SJ. Analysis of the neuroprotective effects of various nitric oxide donor compounds in murine mixed cortical cell culture. Journal of Neurochemistry. 72: 1843-52. PMID 10217260 DOI: 10.1046/J.1471-4159.1999.0721843.X  0.313
1999 Fukuto JM, Wink DA. Nitric oxide (NO): formation and biological roles in mammalian systems Metal Ions in Biological Systems. 36: 547-595. PMID 10093936 DOI: 10.1201/9780203747605-17  0.376
1999 Grisham MB, Jourd'heuil D, Wink DA. I. Physiological chemistry of nitric oxide and its metabolites: Implications in inflammation American Journal of Physiology - Gastrointestinal and Liver Physiology. 276. PMID 9950804 DOI: 10.1152/Ajpgi.1999.276.2.G315  0.378
1999 Wink DA, Vodovotz Y, Grisham MB, DeGraff W, Cook JC, Pacelli R, Krishna M, Mitchell JB. Antioxidant effects of nitric oxide. Methods in Enzymology. 301: 413-24. PMID 9919590 DOI: 10.1016/S0076-6879(99)01105-2  0.392
1999 Jourd'heuil D, Laroux FS, Miles AM, Wink DA, Grisham MB. Effect of superoxide dismutase on the stability of S-nitrosothiols. Archives of Biochemistry and Biophysics. 361: 323-30. PMID 9882463 DOI: 10.1006/Abbi.1998.1010  0.302
1999 OKAYAMA N, GRISHAM MB, KEVIL CG, EPPIHIMER LA, WINK DA, ALEXANDER JS. Effect of Reactive Oxygen Metabolites on Endothelial Permeability: Role of Nitric Oxide and Iron Microcirculation. 6: 107-116. DOI: 10.1111/J.1549-8719.1999.Tb00093.X  0.323
1999 KOTSONIS P, FREY A, FRÖHLICH LG, HOFMANN H, REIF A, WINK DA, FEELISCH M, SCHMIDT HH. Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity Biochemical Journal. 340: 745. DOI: 10.1042/Bj3400745  0.375
1998 Mitchell JB, Degraff W, Kim S, Cook JA, Gamson J, Christodoulou D, Feelisch M, Wink DA. Redox generation of nitric oxide to radiosensitize hypoxic cells International Journal of Radiation Oncology Biology Physics. 42: 795-798. PMID 9845098 DOI: 10.1016/S0360-3016(98)00327-7  0.371
1998 McKinney LC, Aquilla EM, Coffin D, Wink DA, Vodovotz Y. Ionizing radiation potentiates the induction of nitric oxide synthase by IFN-gamma and/or LPS in murine macrophage cell lines: role of TNF-alpha. Journal of Leukocyte Biology. 64: 459-66. PMID 9766626 DOI: 10.1002/Jlb.64.4.459  0.318
1998 Wink DA, Mitchell JB. Chemical biology of nitric oxide: Insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide. Free Radical Biology & Medicine. 25: 434-56. PMID 9741580 DOI: 10.1016/S0891-5849(98)00092-6  0.411
1998 Wink DA, Vodovotz Y, Laval J, Laval F, Dewhirst MW, Mitchell JB. The multifaceted roles of nitric oxide in cancer. Carcinogenesis. 19: 711-21. PMID 9635855 DOI: 10.1093/Carcin/19.5.711  0.475
1998 Jourd'heuil D, Mai CT, Laroux FS, Wink DA, Grisham MB. The reaction of S-nitrosoglutathione with superoxide. Biochemical and Biophysical Research Communications. 244: 525-30. PMID 9514894 DOI: 10.1006/Bbrc.1998.8227  0.315
1998 Wink DA, Feelisch M, Fukuto J, Chistodoulou D, Jourd'heuil D, Grisham MB, Vodovotz Y, Cook JA, Krishna M, DeGraff WG, Kim S, Gamson J, Mitchell JB. The cytotoxicity of nitroxyl: Possible implications for the pathophysiological role of NO Archives of Biochemistry and Biophysics. 351: 66-74. PMID 9501920 DOI: 10.1006/Abbi.1997.0565  0.427
1997 Wink DA, Cook JA, Christodoulou D, Krishna MC, Pacelli R, Kim S, Degraff W, Gamson J, Vodovotz Y, Russo A, Mitchell JB. Nitric oxide and some nitric oxide donor compounds enhance the cytotoxicity of cisplatin Nitric Oxide - Biology and Chemistry. 1: 88-94. PMID 9701048 DOI: 10.1006/Niox.1996.0108  0.387
1997 Cook JA, Krishna MC, Pacelli R, DeGraff W, Liebmann J, Mitchell JB, Russo A, Wink DA. Nitric oxide enhancement of melphalan-induced cytotoxicity. British Journal of Cancer. 76: 325-34. PMID 9252199 DOI: 10.1038/Bjc.1997.386  0.398
1997 Wink DA, Cook JA, Kim SY, Vodovotz Y, Pacelli R, Krishna MC, Russo A, Mitchell JB, Jourd'heuil D, Miles AM, Grisham MB. Superoxide modulates the oxidation and nitrosation of thiols by nitric oxide-derived reactive intermediates. Chemical aspects involved in the balance between oxidative and nitrosative stress Journal of Biological Chemistry. 272: 11147-11151. PMID 9111012 DOI: 10.1074/Jbc.272.17.11147  0.371
1997 Kelm M, Dahmann R, Wink D, Feelisch M. The nitric oxide/superoxide assay. Insights into the biological chemistry of the NO/O-2. interaction. The Journal of Biological Chemistry. 272: 9922-32. PMID 9092531 DOI: 10.1074/Jbc.272.15.9922  0.326
1997 Keefer LK, Wink DA. DNA damage and nitric oxide. Advances in Experimental Medicine and Biology. 387: 177-85. PMID 8794210 DOI: 10.1007/978-1-4757-9480-9_24  0.334
1997 Keefer LK, Nims RW, Davies KM, Wink DA. "NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms. Methods in Enzymology. 268: 281-93. PMID 8782594 DOI: 10.1016/S0076-6879(96)68030-6  0.375
1997 Bourassa J, DeGraff W, Kudo S, Wink DA, Mitchell JB, Ford PC. Photochemistry of Roussin's red salt, Na2[Fe2S2(NO)4], and of Roussin's black salt, NH4[Fe4S3(NO)7]. In situ nitric oxide generation to sensitize γ-radiation induced cell death Journal of the American Chemical Society. 119: 2853-2860. DOI: 10.1021/Ja963914N  0.34
1996 Misra RR, Hochadel JF, Smith GT, Cook JC, Waalkes MP, Wink DA. Evidence that nitric oxide enhances cadmium toxicity by displacing the metal from metallothionein. Chemical Research in Toxicology. 9: 326-32. PMID 8924612 DOI: 10.1021/Tx950109Y  0.306
1996 Cook JA, Wink DA, Blount V, Krishna MC, Hanbauer I. Role of antioxidants in the nitric oxide-elicited inhibition of dopamine uptake in cultured mesencephalic neurons. Insights into potential mechanisms of nitric oxide-mediated neurotoxicity. Neurochemistry International. 28: 609-17. PMID 8792343 DOI: 10.1016/0197-0186(95)00125-5  0.314
1996 Wink DA, Grisham MB, Miles AM, Nims RW, Krishna MC, Pacelli R, Teague D, Poore CM, Cook JA, Ford PC. Determination of selectivity of reactive nitrogen oxide species for various substrates. Methods in Enzymology. 268: 120-30. PMID 8782578 DOI: 10.1016/S0076-6879(96)68014-8  0.341
1996 Miles AM, Wink DA, Cook JC, Grisham MB. Determination of nitric oxide using fluorescence spectroscopy. Methods in Enzymology. 268: 105-20. PMID 8782577 DOI: 10.1016/S0076-6879(96)68013-6  0.337
1996 Nims RW, Cook JC, Krishna MC, Christodoulou D, Poore CM, Miles AM, Grisham MB, Wink DA. Colorimetric assays for nitric oxide and nitrogen oxide species formed from nitric oxide stock solutions and donor compounds. Methods in Enzymology. 268: 93-105. PMID 8782576 DOI: 10.1016/S0076-6879(96)68012-4  0.385
1996 Christodoulou D, Kudo S, Cook JA, Krishna MC, Miles A, Grisham MB, Murugesan M, Ford PC, Wink DA. Electrochemical methods for detection of nitric oxide. Methods in Enzymology. 268: 69-83. PMID 8782574 DOI: 10.1016/S0076-6879(96)68010-0  0.346
1996 Wink DA, Grisham MB, Mitchell JB, Ford PC. Direct and indirect effects of nitric oxide in chemical reactions relevant to biology. Methods in Enzymology. 268: 12-31. PMID 8782570 DOI: 10.1016/S0076-6879(96)68006-9  0.336
1996 Wink DA, Cook JA, Pacelli R, DeGraff W, Gamson J, Liebmann J, Krishna MC, Mitchell JB. The effect of various nitric oxide-donor agents on hydrogen peroxide- mediated toxicity: A direct correlation between nitric oxide formation and protection Archives of Biochemistry and Biophysics. 331: 241-248. PMID 8660704 DOI: 10.1006/Abbi.1996.0304  0.381
1996 Wink DA, Hanbauer I, Grisham MB, Laval F, Nims RW, Laval J, Cook J, Pacelli R, Liebmann J, Krishna M, Ford PC, Mitchell JB. Chemical biology of nitric oxide: regulation and protective and toxic mechanisms. Current Topics in Cellular Regulation. 34: 159-87. PMID 8646847 DOI: 10.1016/S0070-2137(96)80006-9  0.424
1996 Pacelli R, Taira J, Cook JA, Wink DA, Krishna MC. Hydroxyurea reacts with heme proteins to generate nitric oxide. Lancet (London, England). 347: 900. PMID 8622413 DOI: 10.1016/S0140-6736(96)91378-1  0.371
1996 Wink DA, Cook JA, Pacelli R, Liebmann J, Krishna MC, Mitchell JB. Nitric oxide (NO) protects against cellular damage by reactive oxygen species. Toxicology Letters. 221-6. PMID 8597056 DOI: 10.1016/0378-4274(95)03557-5  0.412
1995 Routledge MN, Wink DA, Keefer LK, Dipple A. DNA sequence changes induced by two nitric oxide donor drugs in the supF assay. Chemical Research in Toxicology. 7: 628-32. PMID 7841341 DOI: 10.1021/Tx00041A007  0.335
1995 Wink DA, Hanbauer I, Laval F, Cook JA, Krishna MC, Mitchell JB. Nitric oxide protects against the cytotoxic effects of reactive oxygen species. Annals of the New York Academy of Sciences. 738: 265-78. PMID 7832437 DOI: 10.1111/J.1749-6632.1994.Tb21812.X  0.372
1995 Wink DA, Cook JA, Krishna MC, Hanbauer I, Degraff W, Gamson J, Mitchell JB. Nitric Oxide Protects against Alkyl Peroxide-Mediated Cytotoxicity: Further Insights into the Role Nitric Oxide Plays in Oxidative Stress Archives of Biochemistry and Biophysics. 319: 402-407. PMID 7786021 DOI: 10.1006/Abbi.1995.1310  0.393
1995 Clarkson RB, Norby SW, Smirnov A, Boyer S, Vahidi N, Nims RW, Wink DA. Direct measurement of the accumulation and mitochondrial conversion of nitric oxide within Chinese hamster ovary cells using an intracellular electron paramagnetic resonance technique. Biochimica Et Biophysica Acta. 1243: 496-502. PMID 7727525 DOI: 10.1016/0304-4165(94)00181-V  0.324
1995 Pacelli R, Wink DA, Cook JA, Krishna MC, DeGraff W, Friedman N, Tsokos M, Samuni A, Mitchell JB. Nitric oxide potentiates hydrogen peroxide-induced killing of Escherichia coli. The Journal of Experimental Medicine. 182: 1469-79. PMID 7595217 DOI: 10.1084/Jem.182.5.1469  0.391
1995 Sheffler LA, Wink DA, Melillo G, Cox GW. Characterization of nitric oxide-stimulated ADP-ribosylation of various proteins from the mouse macrophage cell line ANA-1 using sodium nitroprusside and the novel nitric oxide-donating compound diethylamine dinitric oxide. Journal of Leukocyte Biology. 57: 152-9. PMID 7530278 DOI: 10.1002/Jlb.57.1.152  0.394
1995 Miles AM, Gibson MF, Kirshina M, Cook JC, Pacelli R, Wink D, Grisham MB. Effects of superoxide on nitric oxide-dependent N-nitrosation reactions. Free Radical Research. 23: 379-90. PMID 7493044 DOI: 10.3109/10715769509065259  0.351
1995 Keefer L, Anderson L, Diwan B, Driver C, Haines D, Maragos C, Wink D, Rice J. Experimental Tests of the Mutagenicity and Carcinogenicity of Nitric Oxide and Its Progenitors Methods. 7: 121-130. DOI: 10.1006/Meth.1995.1018  0.387
1995 Wink DA, Christodoulou D, Ho M, Krishna MC, Cook JA, Haut H, Randolph JK, Sullivan M, Coia G, Murray R, Meyer T. A Discussion of Electrochemical Techniques for the Detection of Nitric Oxide Methods. 7: 71-77. DOI: 10.1006/Meth.1995.1010  0.318
1995 Nims RW, Darbyshire JF, Saavedra JE, Christodoulou D, Hanbauer I, Cox GW, Grisham MB, Laval F, Cook JA, Krishna MC, Wink DA. Colorimetric methods for the determination of nitric oxide concentration in neutral aqueous solutions Methods: a Companion to Methods in Enzymology. 7: 48-54. DOI: 10.1006/Meth.1995.1007  0.322
1995 Wink DA, Ford PC. Nitric Oxide Reactions Important to Biological Systems: A Survey of Some Kinetics Investigations Methods. 7: 14-20. DOI: 10.1006/Meth.1995.1003  0.376
1994 Laval F, Wink DA. Inhibition by nitric oxide of the repair protein, O6-methylguanine-DNA-methyltransferase. Carcinogenesis. 15: 443-7. PMID 8118926 DOI: 10.1093/Carcin/15.3.443  0.387
1994 Wink DA, Nims RW, Darbyshire JF, Christodoulou D, Hanbauer I, Cox GW, Laval F, Laval J, Cook JA, Krishna MC. Reaction kinetics for nitrosation of cysteine and glutathione in aerobic nitric oxide solutions at neutral pH. Insights into the fate and physiological effects of intermediates generated in the NO/O2 reaction. Chemical Research in Toxicology. 7: 519-25. PMID 7981416 DOI: 10.1021/Tx00040A007  0.344
1994 Wink DA, Laval J. The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo. Carcinogenesis. 15: 2125-9. PMID 7955043 DOI: 10.1093/Carcin/15.10.2125  0.336
1994 Wink DA, Wink CB, Nims RW, Ford PC. Oxidizing intermediates generated in the Fenton reagent: kinetic arguments against the intermediacy of the hydroxyl radical. Environmental Health Perspectives. 102: 11-5. PMID 7843082 DOI: 10.1289/Ehp.94102S311  0.395
1994 Liebmann J, Deluca AM, Coffin D, Venzon DJ, Wink DA, Mitchell JB. Nitric oxide modulation enhances the in vivo protection from lethal irradiation by stem cell factor Radiation Oncology Investigations. 2: 264-268. DOI: 10.1002/Roi.2970020603  0.348
1993 Wink DA, Darbyshire JF, Nims RW, Saavedra JE, Ford PC. Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: determination of the kinetics for oxidation and nitrosation by intermediates generated in the NO/O2 reaction. Chemical Research in Toxicology. 6: 23-7. PMID 8448345 DOI: 10.1021/Tx00031A003  0.376
1993 Wink DA, Osawa Y, Darbyshire JF, Jones CR, Eshenaur SC, Nims RW. Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent. Archives of Biochemistry and Biophysics. 300: 115-23. PMID 8424643 DOI: 10.1006/Abbi.1993.1016  0.335
1993 Routledge MN, Wink DA, Keefer LK, Dipple A. Mutations induced by saturated aqueous nitric oxide in the pSP189 supF gene in human Ad293 and E. coli MBM7070 cells. Carcinogenesis. 14: 1251-4. PMID 8330336 DOI: 10.1093/Carcin/14.7.1251  0.354
1993 Ford PC, Wink DA, Stanbury DM. Autoxidation kinetics of aqueous nitric oxide. Febs Letters. 326: 1-3. PMID 8325356 DOI: 10.1016/0014-5793(93)81748-O  0.334
1993 Wink DA, Hanbauer I, Krishna MC, DeGraff W, Gamson J, Mitchell JB. Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species Proceedings of the National Academy of Sciences of the United States of America. 90: 9813-9817. PMID 8234317 DOI: 10.1073/Pnas.90.21.9813  0.382
1993 Morley D, Maragos CM, Zhang XY, Boignon M, Wink DA, Keefer LK. Mechanism of vascular relaxation induced by the nitric oxide (NO)/nucleophile complexes, a new class of NO-based vasodilators. Journal of Cardiovascular Pharmacology. 21: 670-6. PMID 7681915 DOI: 10.1097/00005344-199304000-00023  0.358
1993 Christodoulou D, Wink DA, Maragos C, George C, Morley D, Keefer LK. Nitric oxide delivery agents: Metal complexes of R1R2N-N2O2- ligands with pharmacological activity. Journal of Inorganic Biochemistry. 51: 384. DOI: 10.1016/0162-0134(93)85413-3  0.326
1991 Maragos CM, Morley D, Wink DA, Dunams TM, Saavedra JE, Hoffman A, Bove AA, Isaac L, Hrabie JA, Keefer LK. Complexes of .NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects. Journal of Medicinal Chemistry. 34: 3242-7. PMID 1956043 DOI: 10.1021/Jm00115A013  0.316
1991 Wink DA, Kasprzak KS, Maragos CM, Elespuru RK, Misra M, Dunams TM, Cebula TA, Koch WH, Andrews AW, Allen JS, Keeper LK. DNA deaminating ability and genotoxicity of nitric oxide and its progenitors Science. 254: 1001-1003. PMID 1948068 DOI: 10.1126/Science.1948068  0.333
1991 Wink DA, Nims RW, Desrosiers MF, Ford PC, Keefer LK. A kinetic investigation of intermediates formed during the Fenton reagent mediated degradation of N-nitrosodimethylamine: evidence for an oxidative pathway not involving hydroxyl radical. Chemical Research in Toxicology. 4: 510-2. PMID 1665352 DOI: 10.1021/Tx00023A002  0.368
1991 Wink DA, Desrosiers MF. Unusual spin-trap chemistry for the reaction of hydroxyl radical with the carcinogen N-nitrosodimethylamine International Journal of Radiation Applications and Instrumentation. Part C. Radiation Physics and Chemistry. 38: 467-472. DOI: 10.1016/1359-0197(91)90063-8  0.311
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