cached image

James A. Spudich - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
myosin
Website:
http://spudlab.stanford.edu/

227 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sarkar SS, Trivedi DV, Morck MM, Adhikari AS, Pasha SN, Ruppel KM, Spudich JA. The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin. Science Advances. 6: eaax0069. PMID 32284968 DOI: 10.1126/Sciadv.Aax0069  0.345
2020 Trivedi DV, Nag S, Spudich A, Ruppel KM, Spudich JA. The Myosin Family of Mechanoenzymes: From Mechanisms to Therapeutic Approaches. Annual Review of Biochemistry. PMID 32169021 DOI: 10.1146/Annurev-Biochem-011520-105234  0.33
2020 Bhowmik D, Nandwani N, Ruppel K, Liu C, Spudich JA. Study of Hcm Causing β-Cardiac Myosin Mutations Located at Different Structurally Significant Regions of the Myosin-Head Biophysical Journal. 118: 435a. DOI: 10.1016/J.Bpj.2019.11.2441  0.689
2019 Vera CD, Johnson CA, Walklate J, Adhikari A, Svicevic M, Mijailovich SM, Combs AC, Langer SJ, Ruppel KM, Spudich JA, Geeves MA, Leinwand LA. Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties. The Journal of Biological Chemistry. PMID 31582565 DOI: 10.1074/Jbc.Ra119.010563  0.339
2019 Adhikari AS, Trivedi DV, Sarkar SS, Song D, Kooiker KB, Bernstein D, Spudich JA, Ruppel KM. β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity. Nature Communications. 10: 2685. PMID 31213605 DOI: 10.1038/S41467-019-10555-9  0.345
2019 Spudich JA. Three perspectives on the molecular basis of hypercontractility caused by hypertrophic cardiomyopathy mutations. Pflugers Archiv : European Journal of Physiology. PMID 30767072 DOI: 10.1007/S00424-019-02259-2  0.339
2018 Wilkinson AW, Diep J, Dai S, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C, Trivedi DV, Ruppel KM, Vilches-Moure JG, Casey KM, Mak J, ... ... Spudich JA, et al. SETD3 is an actin histidine methyltransferase that prevents primary dystocia. Nature. PMID 30626964 DOI: 10.1038/S41586-018-0821-8  0.367
2018 Anderson RL, Trivedi DV, Sarkar SS, Henze M, Ma W, Gong H, Rogers CS, Gorham JM, Wong FL, Morck MM, Seidman JG, Ruppel KM, Irving TC, Cooke R, Green EM, ... Spudich JA, et al. Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers. Proceedings of the National Academy of Sciences of the United States of America. PMID 30104387 DOI: 10.1073/Pnas.1809540115  0.395
2018 Liu C, Kawana M, Song D, Ruppel KM, Spudich JA. Controlling load-dependent kinetics of β-cardiac myosin at the single-molecule level. Nature Structural & Molecular Biology. PMID 29867217 DOI: 10.1038/S41594-018-0069-X  0.384
2018 Ujfalusi Z, Vera CD, Mijailovich SM, Svicevic M, Yu EC, Kawana M, Ruppel K, Spudich JA, Geeves MA, Leinwand LA. Dilated cardiomyopathy myosin mutants have reduced force-generating capacity. The Journal of Biological Chemistry. PMID 29666183 DOI: 10.1074/Jbc.Ra118.001938  0.357
2017 Gangadharan B, Sunitha MS, Mukherjee S, Chowdhury RR, Haque F, Sekar N, Sowdhamini R, Spudich JA, Mercer JA. Molecular mechanisms and structural features of cardiomyopathy-causing troponin T mutants in the tropomyosin overlap region. Proceedings of the National Academy of Sciences of the United States of America. PMID 28973951 DOI: 10.1073/Pnas.1710354114  0.32
2017 Trivedi DV, Adhikari AS, Sarkar SS, Ruppel KM, Spudich JA. Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light. Biophysical Reviews. PMID 28717924 DOI: 10.1007/S12551-017-0274-6  0.4
2017 Nag S, Trivedi DV, Sarkar SS, Adhikari AS, Sunitha MS, Sutton S, Ruppel KM, Spudich JA. The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations. Nature Structural & Molecular Biology. PMID 28481356 DOI: 10.1038/Nsmb.3408  0.354
2017 Kawana M, Sarkar SS, Sutton S, Ruppel KM, Spudich JA. Biophysical properties of human β-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy. Science Advances. 3: e1601959. PMID 28246639 DOI: 10.1126/Sciadv.1601959  0.341
2017 Sung J, Mortensen KI, Spudich JA, Flyvbjerg H. How to Measure Load-Dependent Kinetics of Individual Motor Molecules Without a Force-Clamp. Methods in Enzymology. 582: 1-29. PMID 28062031 DOI: 10.1016/Bs.Mie.2016.08.002  0.421
2017 Sarkar SS, Trivedi D, Adhikari AS, Liu C, Ruppel KM, Spudich JA. Investigation of the Molecular Interactions Regulating the Function of Human Cardiac Myosin Biophysical Journal. 112: 259a. DOI: 10.1016/J.Bpj.2016.11.1408  0.426
2016 Adhikari AS, Kooiker KB, Sarkar SS, Liu C, Bernstein D, Spudich JA, Ruppel KM. Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human β-Cardiac Myosin. Cell Reports. 17: 2857-2864. PMID 27974200 DOI: 10.1016/J.Celrep.2016.11.040  0.358
2016 Mortensen KI, Sung J, Spudich JA, Flyvbjerg H. How to Measure Separations and Angles Between Intramolecular Fluorescent Markers. Methods in Enzymology. 581: 147-185. PMID 27793279 DOI: 10.1016/Bs.Mie.2016.08.020  0.319
2016 Homburger JR, Green EM, Caleshu C, Sunitha MS, Taylor RE, Ruppel KM, Metpally RP, Colan SD, Michels M, Day SM, Olivotto I, Bustamante CD, Dewey FE, Ho CY, Spudich JA, et al. Multidimensional structure-function relationships in human β-cardiac myosin from population-scale genetic variation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27247418 DOI: 10.1073/Pnas.1606950113  0.359
2016 Green EM, Wakimoto H, Anderson RL, Evanchik MJ, Gorham JM, Harrison BC, Henze M, Kawas R, Oslob JD, Rodriguez HM, Song Y, Wan W, Leinwand LA, Spudich JA, McDowell RS, et al. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science (New York, N.Y.). 351: 617-21. PMID 26912705 DOI: 10.1126/Science.Aad3456  0.319
2016 Spudich JA, Aksel T, Bartholomew SR, Nag S, Kawana M, Yu EC, Sarkar SS, Sung J, Sommese RF, Sutton S, Cho C, Adhikari AS, Taylor R, Liu C, Trivedi D, et al. Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin. The Journal of Experimental Biology. 219: 161-7. PMID 26792326 DOI: 10.1242/Jeb.125930  0.388
2015 Nag S, Sommese RF, Ujfalusi Z, Combs A, Langer S, Sutton S, Leinwand LA, Geeves MA, Ruppel KM, Spudich JA. Contractility parameters of human β-cardiac myosin with the hypertrophic cardiomyopathy mutation R403Q show loss of motor function. Science Advances. 1: e1500511. PMID 26601291 DOI: 10.1126/Sciadv.1500511  0.402
2015 Mortensen KI, Sung J, Flyvbjerg H, Spudich JA. Optimized measurements of separations and angles between intra-molecular fluorescent markers. Nature Communications. 6: 8621. PMID 26509412 DOI: 10.1038/Ncomms9621  0.328
2015 Pan S, Sommese RF, Sallam KI, Nag S, Sutton S, Miller SM, Spudich JA, Ruppel KM, Ashley EA. Establishing disease causality for a novel gene variant in familial dilated cardiomyopathy using a functional in-vitro assay of regulated thin filaments and human cardiac myosin. Bmc Medical Genetics. 16: 97. PMID 26498512 DOI: 10.1186/S12881-015-0243-5  0.307
2015 Manor U, Bartholomew S, Golani G, Christenson E, Kozlov M, Higgs H, Spudich J, Lippincott-Schwartz J. A mitochondria-anchored isoform of the actin-nucleating Spire protein regulates mitochondrial division. Elife. 4. PMID 26305500 DOI: 10.7554/Elife.08828  0.316
2015 Sung J, Nag S, Mortensen KI, Vestergaard CL, Sutton S, Ruppel K, Flyvbjerg H, Spudich JA. Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules. Nature Communications. 6: 7931. PMID 26239258 DOI: 10.1038/Ncomms8931  0.399
2015 Hariadi RF, Sommese RF, Adhikari AS, Taylor RE, Sutton S, Spudich JA, Sivaramakrishnan S. Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments. Nature Nanotechnology. PMID 26149240 DOI: 10.1038/Nnano.2015.132  0.812
2015 Aksel T, Choe Yu E, Sutton S, Ruppel KM, Spudich JA. Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector. Cell Reports. 11: 910-20. PMID 25937279 DOI: 10.1016/J.Celrep.2015.04.006  0.307
2015 Spudich JA. The myosin mesa and a possible unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy. Biochemical Society Transactions. 43: 64-72. PMID 25619247 DOI: 10.1042/Bst20140324  0.397
2015 Gupte TM, Haque F, Gangadharan B, Sunitha MS, Mukherjee S, Anandhan S, Rani DS, Mukundan N, Jambekar A, Thangaraj K, Sowdhamini R, Sommese RF, Nag S, Spudich JA, Mercer JA. Mechanistic heterogeneity in contractile properties of α-tropomyosin (TPM1) mutants associated with inherited cardiomyopathies. The Journal of Biological Chemistry. 290: 7003-15. PMID 25548289 DOI: 10.1074/Jbc.M114.596676  0.333
2015 Manor U, Bartholomew S, Golani G, Christenson E, Kozlov M, Higgs H, Spudich J, Lippincott-Schwartz J. Author response: A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division Elife. DOI: 10.7554/Elife.08828.023  0.307
2015 Nag S, Sommese R, Sutton S, Ruppel K, Spudich J. Effects of Hypertrophic Cardiomyopathy Causing R403Q Mutation on Human Beta-Cardiac Myosin Biomechanical Function: Single Molecule to Ensemble Studies Biophysical Journal. 108: 445a. DOI: 10.1016/J.Bpj.2014.11.2432  0.361
2014 Sung J, Nag S, Vestergaard C, Mortensen K, Flyvbjerg H, Spudich J. Harmonic Force Spectroscopy Reveals a Force-Velocity Curve from a Single Human Beta Cardiac Myosin Motor Biophysical Journal. 106: 453a. DOI: 10.1016/J.Bpj.2013.11.2566  0.385
2013 Sommese RF, Nag S, Sutton S, Miller SM, Spudich JA, Ruppel KM. Effects of troponin T cardiomyopathy mutations on the calcium sensitivity of the regulated thin filament and the actomyosin cross-bridge kinetics of human β-cardiac myosin. Plos One. 8: e83403. PMID 24367593 DOI: 10.1371/Journal.Pone.0083403  0.326
2013 Sommese RF, Sung J, Nag S, Sutton S, Deacon JC, Choe E, Leinwand LA, Ruppel K, Spudich JA. Molecular consequences of the R453C hypertrophic cardiomyopathy mutation on human β-cardiac myosin motor function. Proceedings of the National Academy of Sciences of the United States of America. 110: 12607-12. PMID 23798412 DOI: 10.1073/Pnas.1309493110  0.35
2013 Elting MW, Leslie SR, Churchman LS, Korlach J, McFaul CM, Leith JS, Levene MJ, Cohen AE, Spudich JA. Single-molecule fluorescence imaging of processive myosin with enhanced background suppression using linear zero-mode waveguides (ZMWs) and convex lens induced confinement (CLIC). Optics Express. 21: 1189-202. PMID 23389011 DOI: 10.1364/Oe.21.001189  0.737
2012 Margaret Sunitha S, Mercer JA, Spudich JA, Sowdhamini R. Integrative structural modelling of the cardiac thin filament: energetics at the interface and conservation patterns reveal a spotlight on period 2 of tropomyosin. Bioinformatics and Biology Insights. 6: 203-23. PMID 23071391 DOI: 10.4137/Bbi.S9798  0.338
2012 Chuan P, Sivaramakrishnan S, Ashley EA, Spudich JA. Cell-intrinsic functional effects of the α-cardiac myosin Arg-403-Gln mutation in familial hypertrophic cardiomyopathy. Biophysical Journal. 102: 2782-90. PMID 22735528 DOI: 10.1016/J.Bpj.2012.04.049  0.535
2012 Hartman MA, Spudich JA. The myosin superfamily at a glance. Journal of Cell Science. 125: 1627-32. PMID 22566666 DOI: 10.1242/Jcs.094300  0.413
2012 Syamaladevi DP, Spudich JA, Sowdhamini R. Structural and functional insights on the Myosin superfamily. Bioinformatics and Biology Insights. 6: 11-21. PMID 22399849 DOI: 10.4137/Bbi.S8451  0.485
2012 Churchman LS, Spudich JA. Single-molecule high-resolution colocalization of single probes. Cold Spring Harbor Protocols. 2012: 242-5. PMID 22301661 DOI: 10.1101/Pdb.Prot067926  0.692
2012 Churchman LS, Spudich JA. Colocalization of fluorescent probes: accurate and precise registration with nanometer resolution. Cold Spring Harbor Protocols. 2012: 141-9. PMID 22301660 DOI: 10.1101/Pdb.Top067918  0.689
2012 Sheetz M, Spudich J, Vale R. The lasker awards: Motors take centre stage Nature Cell Biology. 14: 1113. DOI: 10.1038/Ncb2618  0.527
2012 Sung J, Choe E, Elting M, Nag S, Sutton S, Deacon J, Leinwand L, Ruppel K, Spudich J. Single Molecule Studies of Recombinant Human α- and β-Cardiac Myosin to Elucidate Molecular Mechanism of Familial Hypertrophic and Dilated Cardiomyopathies Biophysical Journal. 102: 613a-614a. DOI: 10.1016/J.Bpj.2011.11.3345  0.356
2012 Mortensen KI, Sung J, Flyvbjerg H, Spudich JA. Biological Structure from Precise and Accurate Estimation of Fluorophore Orientations and Distances: Proof-of-Principle using Internally Labeled dsDNA Biophysical Journal. 102: 419a-420a. DOI: 10.1016/J.Bpj.2011.11.2294  0.325
2011 Dunn AR, Spudich JA. Single-molecule gold-nanoparticle tracking. Cold Spring Harbor Protocols. 2011: 1498-506. PMID 22135665 DOI: 10.1101/Pdb.Prot066977  0.323
2011 Sivaramakrishnan S, Spudich JA. Systematic control of protein interaction using a modular ER/K α-helix linker. Proceedings of the National Academy of Sciences of the United States of America. 108: 20467-72. PMID 22123984 DOI: 10.1073/Pnas.1116066108  0.536
2011 Spudich JA, Rice SE, Rock RS, Purcell TJ, Warrick HM. The optical trapping dumbbell assay for nonprocessive motors or motors that turn around filaments. Cold Spring Harbor Protocols. 2011: 1372-4. PMID 22046050 DOI: 10.1101/Pdb.Prot066688  0.825
2011 Spudich JA, Rice SE, Rock RS, Purcell TJ, Warrick HM. Attachment of anti-GFP antibodies to microspheres for optical trapping experiments. Cold Spring Harbor Protocols. 2011: 1370-1. PMID 22046049 DOI: 10.1101/Pdb.Prot066670  0.813
2011 Spudich JA, Rice SE, Rock RS, Purcell TJ, Warrick HM. Optical traps to study properties of molecular motors. Cold Spring Harbor Protocols. 2011: 1305-18. PMID 22046048 DOI: 10.1101/Pdb.Top066662  0.821
2011 Hartman MA, Finan D, Sivaramakrishnan S, Spudich JA. Principles of unconventional myosin function and targeting. Annual Review of Cell and Developmental Biology. 27: 133-55. PMID 21639800 DOI: 10.1146/Annurev-Cellbio-100809-151502  0.607
2011 Spudich JA. Biochemistry. Molecular motors, beauty in complexity. Science (New York, N.Y.). 331: 1143-4. PMID 21385703 DOI: 10.1126/Science.1203978  0.46
2011 Finan D, Hartman MA, Spudich JA. Proteomics approach to study the functions of Drosophila myosin VI through identification of multiple cargo-binding proteins. Proceedings of the National Academy of Sciences of the United States of America. 108: 5566-71. PMID 21368190 DOI: 10.1073/Pnas.1101415108  0.414
2011 Elting MW, Bryant Z, Liao JC, Spudich JA. Detailed tuning of structure and intramolecular communication are dispensable for processive motion of myosin VI. Biophysical Journal. 100: 430-9. PMID 21244839 DOI: 10.1016/J.Bpj.2010.11.045  0.763
2011 Purcell TJ, Naber N, Franks-Skiba K, Dunn AR, Eldred CC, Berger CL, Málnási-Csizmadia A, Spudich JA, Swank DM, Pate E, Cooke R. Nucleotide pocket thermodynamics measured by EPR reveal how energy partitioning relates myosin speed to efficiency. Journal of Molecular Biology. 407: 79-91. PMID 21185304 DOI: 10.1016/J.Jmb.2010.11.053  0.749
2011 Chuan P, Spudich JA, Dunn AR. Robust mechanosensing and tension generation by myosin VI. Journal of Molecular Biology. 405: 105-12. PMID 20970430 DOI: 10.1016/J.Jmb.2010.10.010  0.448
2011 Sung J, Mortensen KI, Flyvbjerg H, Spudich JA. Optimal Estimation of Location and Orientation of Myosin V Lever Arm from Focused Diffraction-Limited Images of Single, Double-Bound Fluorophore Biophysical Journal. 100: 477a. DOI: 10.1016/J.Bpj.2010.12.2795  0.331
2010 Sommese RF, Sivaramakrishnan S, Baldwin RL, Spudich JA. Helicity of short E-R/K peptides. Protein Science : a Publication of the Protein Society. 19: 2001-5. PMID 20669185 DOI: 10.1002/Pro.469  0.491
2010 Sung J, Sivaramakrishnan S, Dunn AR, Spudich JA. Single-molecule dual-beam optical trap analysis of protein structure and function. Methods in Enzymology. 475: 321-75. PMID 20627164 DOI: 10.1016/S0076-6879(10)75014-X  0.571
2010 Uehara R, Goshima G, Mabuchi I, Vale RD, Spudich JA, Griffis ER. Determinants of myosin II cortical localization during cytokinesis. Current Biology : Cb. 20: 1080-5. PMID 20541410 DOI: 10.1016/J.Cub.2010.04.058  0.634
2010 Dunn AR, Chuan P, Bryant Z, Spudich JA. Contribution of the myosin VI tail domain to processive stepping and intramolecular tension sensing. Proceedings of the National Academy of Sciences of the United States of America. 107: 7746-50. PMID 20385849 DOI: 10.1016/J.Bpj.2009.12.1242  0.74
2010 Mortensen KI, Churchman LS, Spudich JA, Flyvbjerg H. Optimized localization analysis for single-molecule tracking and super-resolution microscopy. Nature Methods. 7: 377-81. PMID 20364147 DOI: 10.1038/Nmeth.1447  0.676
2010 Spudich JA, Sivaramakrishnan S. Myosin VI: an innovative motor that challenged the swinging lever arm hypothesis. Nature Reviews. Molecular Cell Biology. 11: 128-37. PMID 20094053 DOI: 10.1038/Nrm2833  0.662
2010 Resnicow DI, Deacon JC, Warrick HM, Spudich JA, Leinwand LA. Functional diversity among a family of human skeletal muscle myosin motors. Proceedings of the National Academy of Sciences of the United States of America. 107: 1053-8. PMID 20080549 DOI: 10.1073/Pnas.0913527107  0.333
2010 Chuan P, Spudich JA, Dunn AR. A Model for Myosin VI Kinetics Under Load Biophysical Journal. 98: 723a. DOI: 10.1016/J.Bpj.2009.12.3964  0.338
2010 Elting MW, Bryant ZD, Liao J, Spudich JA. Probing Myosin-VI Processivity using Artificial Lever Arms Biophysical Journal. 98: 723a. DOI: 10.1016/J.Bpj.2009.12.3962  0.781
2010 Sivaramakrishnan S, Ashley E, Leinwand L, Spudich JA. Erratum: Insights into Human β-Cardiac Myosin Function from Single Molecule and Single Cell Studies Journal of Cardiovascular Translational Research. 4: 114-114. DOI: 10.1007/S12265-010-9251-1  0.55
2009 Sivaramakrishnan S, Ashley E, Leinwand L, Spudich JA. Insights into human beta-cardiac myosin function from single molecule and single cell studies. Journal of Cardiovascular Translational Research. 2: 426-40. PMID 20560001 DOI: 10.1007/S12265-009-9129-2  0.58
2009 Sivaramakrishnan S, Sung J, Ali M, Doniach S, Flyvbjerg H, Spudich JA. Combining single-molecule optical trapping and small-angle x-ray scattering measurements to compute the persistence length of a protein ER/K alpha-helix. Biophysical Journal. 97: 2993-9. PMID 19948129 DOI: 10.1016/J.Bpj.2009.09.009  0.554
2009 Sivaramakrishnan S, Spudich JA. Coupled myosin VI motors facilitate unidirectional movement on an F-actin network. The Journal of Cell Biology. 187: 53-60. PMID 19786577 DOI: 10.1083/Jcb.200906133  0.654
2009 Vale RD, Spudich JA, Griffis ER. Dynamics of myosin, microtubules, and Kinesin-6 at the cortex during cytokinesis in Drosophila S2 cells. The Journal of Cell Biology. 186: 727-38. PMID 19720876 DOI: 10.1083/Jcb.200902083  0.602
2009 Liao JC, Elting MW, Delp SL, Spudich JA, Bryant Z. Engineered myosin VI motors reveal minimal structural determinants of directionality and processivity. Journal of Molecular Biology. 392: 862-7. PMID 19631216 DOI: 10.1016/J.Jmb.2009.07.046  0.777
2009 Pierobon P, Achouri S, Courty S, Dunn AR, Spudich JA, Dahan M, Cappello G. Velocity, processivity, and individual steps of single myosin V molecules in live cells. Biophysical Journal. 96: 4268-75. PMID 19450497 DOI: 10.1016/J.Bpj.2009.02.045  0.401
2009 Dietz H, Derr ND, Dunn A, Spudich JA, Shih W. Towards Custom-topology Tracks For Probing Myosin Motor Dynamics Biophysical Journal. 96: 130a. DOI: 10.1016/J.Bpj.2008.12.588  0.776
2009 Chuan P, Dunn AR, Bryant Z, Spudich JA. Structural and Mechanistic Determinants of Myosin VI Processivity and Anchoring Biophysical Journal. 96: 142a. DOI: 10.1016/J.Bpj.2008.12.3883  0.7
2008 Sivaramakrishnan S, Spink BJ, Sim AY, Doniach S, Spudich JA. Dynamic charge interactions create surprising rigidity in the ER/K alpha-helical protein motif. Proceedings of the National Academy of Sciences of the United States of America. 105: 13356-61. PMID 18768817 DOI: 10.1073/Pnas.0806256105  0.743
2008 Spink BJ, Sivaramakrishnan S, Lipfert J, Doniach S, Spudich JA. Long single alpha-helical tail domains bridge the gap between structure and function of myosin VI. Nature Structural & Molecular Biology. 15: 591-7. PMID 18511944 DOI: 10.1038/Nsmb.1429  0.786
2008 Spudich JA. Molecular motors: a surprising twist in myosin VI translocation. Current Biology : Cb. 18: R68-70. PMID 18211842 DOI: 10.1016/J.Cub.2007.11.025  0.476
2007 Tang S, Liao JC, Dunn AR, Altman RB, Spudich JA, Schmidt JP. Predicting allosteric communication in myosin via a pathway of conserved residues. Journal of Molecular Biology. 373: 1361-73. PMID 17900617 DOI: 10.1016/J.Jmb.2007.08.059  0.566
2007 Altman D, Goswami D, Hasson T, Spudich JA, Mayor S. Precise positioning of myosin VI on endocytic vesicles in vivo. Plos Biology. 5: e210. PMID 17683200 DOI: 10.1371/Journal.Pbio.0050210  0.631
2007 Chen Q, Lakshmikanth GS, Spudich JA, De Lozanne A. The localization of inner centromeric protein (INCENP) at the cleavage furrow is dependent on Kif12 and involves interactions of the N terminus of INCENP with the actin cytoskeleton. Molecular Biology of the Cell. 18: 3366-74. PMID 17567958 DOI: 10.1091/Mbc.E06-10-0895  0.402
2007 Geething NC, Spudich JA. Identification of a minimal myosin Va binding site within an intrinsically unstructured domain of melanophilin. The Journal of Biological Chemistry. 282: 21518-28. PMID 17513864 DOI: 10.1074/Jbc.M701932200  0.803
2007 Liao JC, Spudich JA, Parker D, Delp SL. Extending the absorbing boundary method to fit dwell-time distributions of molecular motors with complex kinetic pathways. Proceedings of the National Academy of Sciences of the United States of America. 104: 3171-6. PMID 17360624 DOI: 10.1073/Pnas.0611519104  0.602
2007 Dunn AR, Spudich JA. Dynamics of the unbound head during myosin V processive translocation. Nature Structural & Molecular Biology. 14: 246-8. PMID 17293871 DOI: 10.1038/Nsmb1206  0.422
2007 Bryant Z, Altman D, Spudich JA. The power stroke of myosin VI and the basis of reverse directionality. Proceedings of the National Academy of Sciences of the United States of America. 104: 772-7. PMID 17182734 DOI: 10.1073/Pnas.0610144104  0.762
2006 Dean SO, Spudich JA. Rho kinase's role in myosin recruitment to the equatorial cortex of mitotic Drosophila S2 cells is for myosin regulatory light chain phosphorylation. Plos One. 1: e131. PMID 17205135 DOI: 10.1371/Journal.Pone.0000131  0.385
2006 Churchman LS, Flyvbjerg H, Spudich JA. A non-Gaussian distribution quantifies distances measured with fluorescence localization techniques. Biophysical Journal. 90: 668-71. PMID 16258038 DOI: 10.1529/Biophysj.105.065599  0.682
2005 Dean SO, Rogers SL, Stuurman N, Vale RD, Spudich JA. Distinct pathways control recruitment and maintenance of myosin II at the cleavage furrow during cytokinesis. Proceedings of the National Academy of Sciences of the United States of America. 102: 13473-8. PMID 16174742 DOI: 10.1073/Pnas.0506810102  0.591
2005 Purcell TJ, Sweeney HL, Spudich JA. A force-dependent state controls the coordination of processive myosin V. Proceedings of the National Academy of Sciences of the United States of America. 102: 13873-8. PMID 16150709 DOI: 10.1073/Pnas.0506441102  0.772
2005 Rock RS, Ramamurthy B, Dunn AR, Beccafico S, Rami BR, Morris C, Spink BJ, Franzini-Armstrong C, Spudich JA, Sweeney HL. A flexible domain is essential for the large step size and processivity of myosin VI. Molecular Cell. 17: 603-9. PMID 15721263 DOI: 10.1016/J.Molcel.2005.01.015  0.822
2005 Churchman LS, Okten Z, Rock RS, Dawson JF, Spudich JA. Single molecule high-resolution colocalization of Cy3 and Cy5 attached to macromolecules measures intramolecular distances through time. Proceedings of the National Academy of Sciences of the United States of America. 102: 1419-23. PMID 15668396 DOI: 10.1073/Pnas.0409487102  0.793
2005 Hostetter D, Rice S, Dean S, Altman D, McMahon PM, Sutton S, Tripathy A, Spudich JA. Correction: Dictyostelium Myosin Bipolar Thick Filament Formation: Importance of Charge and Specific Domains of the Myosin Rod Plos Biology. 3: e119. DOI: 10.1371/Journal.Pbio.0030119  0.799
2004 Hostetter D, Rice S, Dean S, Altman D, McMahon PM, Sutton S, Tripathy A, Spudich JA. Dictyostelium myosin bipolar thick filament formation: importance of charge and specific domains of the myosin rod. Plos Biology. 2: e356. PMID 15492777 DOI: 10.1371/Journal.Pbio.0020356  0.806
2004 Okten Z, Churchman LS, Rock RS, Spudich JA. Myosin VI walks hand-over-hand along actin. Nature Structural & Molecular Biology. 11: 884-7. PMID 15286724 DOI: 10.1038/Nsmb815  0.82
2004 Robinson DN, Spudich JA. Mechanics and regulation of cytokinesis. Current Opinion in Cell Biology. 16: 182-8. PMID 15196562 DOI: 10.1016/J.Ceb.2004.02.002  0.59
2004 Altman D, Sweeney HL, Spudich JA. The mechanism of myosin VI translocation and its load-induced anchoring. Cell. 116: 737-49. PMID 15006355 DOI: 10.1016/S0092-8674(04)00211-9  0.575
2003 Rice SE, Purcell TJ, Spudich JA. Building and using optical traps to study properties of molecular motors. Methods in Enzymology. 361: 112-33. PMID 12624909 DOI: 10.1016/S0076-6879(03)61008-6  0.787
2003 Dawson JF, Sablin EP, Spudich JA, Fletterick RJ. Structure of an F-actin trimer disrupted by gelsolin and implications for the mechanism of severing. The Journal of Biological Chemistry. 278: 1229-38. PMID 12356759 DOI: 10.1074/Jbc.M209160200  0.432
2003 Rock RS, Purcell TJ, Spudich JA. Mechanics of Unconventional Myosins Enzymes. 23: 55-86. DOI: 10.1016/S1874-6047(04)80003-9  0.824
2002 Purcell TJ, Morris C, Spudich JA, Sweeney HL. Role of the lever arm in the processive stepping of myosin V. Proceedings of the National Academy of Sciences of the United States of America. 99: 14159-64. PMID 12386339 DOI: 10.1073/Pnas.182539599  0.771
2002 Sablin EP, Dawson JF, VanLoock MS, Spudich JA, Egelman EH, Fletterick RJ. How does ATP hydrolysis control actin's associations? Proceedings of the National Academy of Sciences of the United States of America. 99: 10945-7. PMID 12167670 DOI: 10.1073/Pnas.152329899  0.401
2002 Liang W, Licate L, Warrick H, Spudich J, Egelhoff T. Differential localization in cells of myosin II heavy chain kinases during cytokinesis and polarized migration Bmc Cell Biology [Electronic Resource]. 3: 19. PMID 12139770 DOI: 10.1186/1471-2121-3-19  0.403
2002 Robinson DN, Cavet G, Warrick HM, Spudich JA. Quantitation of the distribution and flux of myosin-II during cytokinesis. Bmc Cell Biology. 3: 4. PMID 11860600 DOI: 10.1186/1471-2121-3-4  0.633
2002 Robinson DN, Ocon SS, Rock RS, Spudich JA. Dynacortin is a novel actin bundling protein that localizes to dynamic actin structures. The Journal of Biological Chemistry. 277: 9088-95. PMID 11782490 DOI: 10.1074/Jbc.M112144200  0.783
2002 Spudich JA, Rock RS. A crossbridge too far. Nature Cell Biology. 4: E8-10. PMID 11780133 DOI: 10.1038/Ncb0102-E8  0.719
2001 Rock RS, Rice SE, Wells AL, Purcell TJ, Spudich JA, Sweeney HL. Myosin VI is a processive motor with a large step size. Proceedings of the National Academy of Sciences of the United States of America. 98: 13655-9. PMID 11707568 DOI: 10.1073/Pnas.191512398  0.837
2001 Spudich JA. The myosin swinging cross-bridge model. Nature Reviews. Molecular Cell Biology. 2: 387-92. PMID 11331913 DOI: 10.1038/35073086  0.398
2001 Shih WM, Spudich JA. The myosin relay helix to converter interface remains intact throughout the actomyosin ATPase cycle. The Journal of Biological Chemistry. 276: 19491-4. PMID 11278776 DOI: 10.1074/Jbc.M010887200  0.689
2001 Murphy CT, Rock RS, Spudich JA. A myosin II mutation uncouples ATPase activity from motility and shortens step size. Nature Cell Biology. 3: 311-5. PMID 11231583 DOI: 10.1038/35060110  0.758
2000 Rock RS, Rief M, Mehta AD, Spudich JA. In vitro assays of processive myosin motors. Methods (San Diego, Calif.). 22: 373-81. PMID 11133243 DOI: 10.1006/Meth.2000.1089  0.79
2000 Shih WM, Gryczynski Z, Lakowicz JR, Spudich JA. A FRET-based sensor reveals large ATP hydrolysis-induced conformational changes and three distinct states of the molecular motor myosin. Cell. 102: 683-94. PMID 11007486 DOI: 10.1016/S0092-8674(00)00090-8  0.661
2000 Murphy CT, Spudich JA. Variable surface loops and myosin activity: accessories to a motor. Journal of Muscle Research and Cell Motility. 21: 139-51. PMID 10961838 DOI: 10.1023/A:1005610007209  0.615
2000 Robinson DN, Spudich JA. Dynacortin, a genetic link between equatorial contractility and global shape control discovered by library complementation of a Dictyostelium discoideum cytokinesis mutant. The Journal of Cell Biology. 150: 823-38. PMID 10953006 DOI: 10.1083/Jcb.150.4.823  0.603
2000 Rief M, Rock RS, Mehta AD, Mooseker MS, Cheney RE, Spudich JA. Myosin-V stepping kinetics: a molecular model for processivity. Proceedings of the National Academy of Sciences of the United States of America. 97: 9482-6. PMID 10944217 DOI: 10.1073/Pnas.97.17.9482  0.776
2000 Robinson DN, Spudich JA. Towards a molecular understanding of cytokinesis. Trends in Cell Biology. 10: 228-37. PMID 10802538 DOI: 10.1016/S0962-8924(00)01747-5  0.6
2000 Nock S, Liang W, Warrick HM, Spudich JA. Mutational analysis of phosphorylation sites in the Dictyostelium myosin II tail: disruption of myosin function by a single charge change. Febs Letters. 466: 267-72. PMID 10682841 DOI: 10.1016/S0014-5793(99)01796-2  0.422
1999 Liang W, Warrick HM, Spudich JA. A structural model for phosphorylation control of Dictyostelium myosin II thick filament assembly. The Journal of Cell Biology. 147: 1039-48. PMID 10579723 DOI: 10.1083/Jcb.147.5.1039  0.397
1999 Mehta AD, Rock RS, Rief M, Spudich JA, Mooseker MS, Cheney RE. Myosin-V is a processive actin-based motor. Nature. 400: 590-3. PMID 10448864 DOI: 10.1038/23072  0.785
1999 Mehta AD, Rief M, Spudich JA. Biomechanics, one molecule at a time. The Journal of Biological Chemistry. 274: 14517-20. PMID 10329637 DOI: 10.1074/Jbc.274.21.14517  0.544
1999 Murphy CT, Spudich JA. The sequence of the myosin 50-20K loop affects Myosin's affinity for actin throughout the actin-myosin ATPase cycle and its maximum ATPase activity. Biochemistry. 38: 3785-92. PMID 10090768 DOI: 10.1021/Bi9826815  0.629
1999 Goodson HV, Warrick HM, Spudich JA. Specialized conservation of surface loops of myosin: evidence that loops are involved in determining functional characteristics. Journal of Molecular Biology. 287: 173-85. PMID 10074415 DOI: 10.1006/Jmbi.1999.2565  0.696
1999 Mehta AD, Rief M, Spudich JA, Smith DA, Simmons RM. Single-molecule biomechanics with optical methods. Science (New York, N.Y.). 283: 1689-95. PMID 10073927 DOI: 10.1126/Science.283.5408.1689  0.616
1998 Zang JH, Spudich JA. Myosin II localization during cytokinesis occurs by a mechanism that does not require its motor domain. Proceedings of the National Academy of Sciences of the United States of America. 95: 13652-7. PMID 9811855 DOI: 10.1073/Pnas.95.23.13652  0.669
1998 Silveira LA, Smith JL, Tan JL, Spudich JA. MLCK-A, an unconventional myosin light chain kinase from Dictyostelium, is activated by a cGMP-dependent pathway. Proceedings of the National Academy of Sciences of the United States of America. 95: 13000-5. PMID 9789030 DOI: 10.1073/Pnas.95.22.13000  0.317
1998 Liang W, Spudich JA. Nucleotide-dependent conformational change near the fulcrum region in Dictyostelium myosin II. Proceedings of the National Academy of Sciences of the United States of America. 95: 12844-7. PMID 9789002 DOI: 10.1073/Pnas.95.22.12844  0.386
1998 Mehta AD, Pullen KA, Spudich JA. Single molecule biochemistry using optical tweezers. Febs Letters. 430: 23-7. PMID 9678588 DOI: 10.1016/S0014-5793(98)00594-8  0.334
1998 Friedman AL, Geeves MA, Manstein DJ, Spudich JA. Kinetic characterization of myosin head fragments with long-lived myosin.ATP states. Biochemistry. 37: 9679-87. PMID 9657680 DOI: 10.1021/Bi973143F  0.436
1998 Moores SL, Spudich JA. Conditional loss-of-myosin-II-function mutants reveal a position in the tail that is critical for filament nucleation. Molecular Cell. 1: 1043-50. PMID 9651587 DOI: 10.1016/S1097-2765(00)80104-5  0.4
1998 Murphy CT, Spudich JA. Dictyostelium myosin 25-50K loop substitutions specifically affect ADP release rates. Biochemistry. 37: 6738-44. PMID 9578557 DOI: 10.1021/Bi972903J  0.614
1997 Zang JH, Cavet G, Sabry JH, Wagner P, Moores SL, Spudich JA. On the role of myosin-II in cytokinesis: division of Dictyostelium cells under adhesive and nonadhesive conditions. Molecular Biology of the Cell. 8: 2617-29. PMID 9398680 DOI: 10.1091/Mbc.8.12.2617  0.623
1997 Sabry JH, Moores SL, Ryan S, Zang JH, Spudich JA. Myosin heavy chain phosphorylation sites regulate myosin localization during cytokinesis in live cells. Molecular Biology of the Cell. 8: 2605-15. PMID 9398679 DOI: 10.1091/Mbc.8.12.2605  0.678
1997 Patterson B, Ruppel KM, Wu Y, Spudich JA. Cold-sensitive mutants G680V and G691C of Dictyostelium myosin II confer dramatically different biochemical defects. The Journal of Biological Chemistry. 272: 27612-7. PMID 9346898 DOI: 10.1074/Jbc.272.44.27612  0.404
1997 Giese KC, Spudich JA. Phenotypically selected mutations in myosin's actin binding domain demonstrate intermolecular contacts important for motor function. Biochemistry. 36: 8465-73. PMID 9214290 DOI: 10.1021/Bi963141F  0.434
1997 Sabry J, Moores S, Ryan S, Zang J, Spudich JA. Studies on the Dynamic Localization of GFP-Myosin During Cytokinesis in Live Cells Microscopy and Microanalysis. 3: 129-130. DOI: 10.1017/S1431927600007534  0.586
1996 Ruppel KM, Spudich JA. Structure-function analysis of the motor domain of myosin. Annual Review of Cell and Developmental Biology. 12: 543-73. PMID 8970737 DOI: 10.1146/Annurev.Cellbio.12.1.543  0.404
1996 Ruppel KM, Spudich JA. Structure-function studies of the myosin motor domain: importance of the 50-kDa cleft. Molecular Biology of the Cell. 7: 1123-36. PMID 8862525 DOI: 10.1091/Mbc.7.7.1123  0.414
1996 Coppin CM, Finer JT, Spudich JA, Vale RD. Detection of sub-8-nm movements of kinesin by high-resolution optical-trap microscopy. Proceedings of the National Academy of Sciences of the United States of America. 93: 1913-7. PMID 8700858 DOI: 10.1073/Pnas.93.5.1913  0.605
1996 Goodson HV, Anderson BL, Warrick HM, Pon LA, Spudich JA. Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton. The Journal of Cell Biology. 133: 1277-91. PMID 8682864 DOI: 10.1083/Jcb.133.6.1277  0.719
1996 Uyeda TQ, Abramson PD, Spudich JA. The neck region of the myosin motor domain acts as a lever arm to generate movement. Proceedings of the National Academy of Sciences of the United States of America. 93: 4459-64. PMID 8633089 DOI: 10.1073/Pnas.93.9.4459  0.419
1996 Moores SL, Sabry JH, Spudich JA. Myosin dynamics in live Dictyostelium cells. Proceedings of the National Academy of Sciences of the United States of America. 93: 443-6. PMID 8552657 DOI: 10.1073/Pnas.93.1.443  0.435
1995 Coppin CM, Finer JT, Spudich JA, Vale RD. Measurement of the isometric force exerted by a single kinesin molecule. Biophysical Journal. 68: 242S-244S. PMID 7787084  0.492
1995 Ruppel KM, Spudich JA. Myosin motor function: structural and mutagenic approaches. Current Opinion in Cell Biology. 7: 89-93. PMID 7755994 DOI: 10.1016/0955-0674(95)80049-2  0.399
1995 Goodson HV, Spudich JA. Identification and molecular characterization of a yeast myosin I. Cell Motility and the Cytoskeleton. 30: 73-84. PMID 7728870 DOI: 10.1002/Cm.970300109  0.679
1995 Ruppel KM, Lorenz M, Spudich JA. Myosin structure/function: a combined mutagenesis-crystallography approach. Current Opinion in Structural Biology. 5: 181-6. PMID 7648319 DOI: 10.1016/0959-440X(95)80073-5  0.382
1994 Uyeda TQ, Ruppel KM, Spudich JA. Enzymatic activities correlate with chimaeric substitutions at the actin-binding face of myosin. Nature. 368: 567-9. PMID 8139694 DOI: 10.1038/368567A0  0.426
1994 Finer JT, Simmons RM, Spudich JA. Single myosin molecule mechanics: piconewton forces and nanometre steps. Nature. 368: 113-9. PMID 8139653 DOI: 10.1038/368113A0  0.397
1994 LeBlanc-Straceski JM, Fukui Y, Sohn RL, Spudich JA, Leinwand LA. Functional analysis of a cardiac myosin rod in Dictyostelium discoideum. Cell Motility and the Cytoskeleton. 27: 313-26. PMID 8069939 DOI: 10.1002/Cm.970270404  0.422
1994 Ruppel KM, Uyeda TQ, Spudich JA. Role of highly conserved lysine 130 of myosin motor domain. In vivo and in vitro characterization of site specifically mutated myosin. The Journal of Biological Chemistry. 269: 18773-80. PMID 8034630  0.385
1994 Springer ML, Patterson B, Spudich JA. Stage-specific requirement for myosin II during Dictyostelium development. Development (Cambridge, England). 120: 2651-60. PMID 7956839  0.618
1994 Lee RJ, Egelhoff TT, Spudich JA. Molecular genetic truncation analysis of filament assembly and phosphorylation domains of Dictyostelium myosin heavy chain. Journal of Cell Science. 107: 2875-86. PMID 7876354  0.367
1993 Goodson HV, Spudich JA. Molecular evolution of the myosin family: relationships derived from comparisons of amino acid sequences. Proceedings of the National Academy of Sciences of the United States of America. 90: 659-63. PMID 8421702 DOI: 10.1073/Pnas.90.2.659  0.666
1993 Titus MA, Wessels D, Spudich JA, Soll D. The unconventional myosin encoded by the myoA gene plays a role in Dictyostelium motility. Molecular Biology of the Cell. 4: 233-46. PMID 8382977 DOI: 10.1091/Mbc.4.2.233  0.561
1993 Schröder RR, Manstein DJ, Jahn W, Holden H, Rayment I, Holmes KC, Spudich JA. Three-dimensional atomic model of F-actin decorated with Dictyostelium myosin S1. Nature. 364: 171-4. PMID 8321290 DOI: 10.1038/364171A0  0.427
1993 Uyeda TQ, Spudich JA. A functional recombinant myosin II lacking a regulatory light chain-binding site. Science (New York, N.Y.). 262: 1867-70. PMID 8266074 DOI: 10.1126/Science.8266074  0.416
1993 Warrick HM, Simmons RM, Finer JT, Uyeda TQ, Chu S, Spudich JA. In vitro methods for measuring force and velocity of the actin-myosin interaction using purified proteins Methods in Cell Biology. 39: 1-21. PMID 8246790 DOI: 10.1016/S0091-679X(08)60158-2  0.499
1993 Simmons RM, Finer JT, Warrick HM, Kralik B, Chu S, Spudich JA, Yanagida T, Oiwa K, Lombardi V, Huxley. Force on single actin filaments in a motility assay measured with an optical trap Advances in Experimental Medicine and Biology. 332: 331-337. PMID 8109348 DOI: 10.1007/978-1-4615-2872-2_32  0.374
1993 Egelhoff TT, Lee RJ, Spudich JA. Dictyostelium myosin heavy chain phosphorylation sites regulate myosin filament assembly and localization in vivo Cell. 75: 363-371. PMID 7691416 DOI: 10.1016/0092-8674(93)80077-R  0.42
1992 Kron SJ, Drubin DG, Botstein D, Spudich JA. Yeast actin filaments display ATP-dependent sliding movement over surfaces coated with rabbit muscle myosin Proceedings of the National Academy of Sciences of the United States of America. 89: 4466-4470. PMID 1533933 DOI: 10.1073/Pnas.89.10.4466  0.664
1992 Kubalek EW, Uyeda TQP, Spudich JA. A Dictyostelium myosin II lacking a proximal 58-kDa portion of the tail is functional in vitro and in vivo Molecular Biology of the Cell. 3: 1455-1462. PMID 1493338 DOI: 10.1091/Mbc.3.12.1455  0.393
1991 Kron SJ, Toyoshima YY, Uyeda TQP, Spudich JA. Assays for actin sliding movement over myosin-coated surfaces Methods in Enzymology. 196: 399-416. PMID 2034132 DOI: 10.1016/0076-6879(91)96035-P  0.638
1991 Egelhoff TT, Titus MA, Manstein DJ, Ruppel KM, Spudich JA. Molecular genetic tools for study of the cytoskeleton in Dictyostelium. Methods in Enzymology. 196: 319-34. PMID 2034127 DOI: 10.1016/0076-6879(91)96029-Q  0.557
1991 Egelhoff TT, Brown SS, Spudich JA. Spatial and temporal control of nonmuscle myosin localization: identification of a domain that is necessary for myosin filament disassembly in vivo. The Journal of Cell Biology. 112: 677-88. PMID 1899668 DOI: 10.1083/Jcb.112.4.677  0.417
1991 Kron SJ, Uyeda TQP, Warrick HM, Spudich JA. An approach to reconstituting motility of single myosin molecules Journal of Cell Science. 98: 129-133. PMID 1885651 DOI: 10.1242/Jcs.1991.Supplement_14.26  0.687
1991 Uyeda TQP, Warrick HM, Kron SJ, Spudich JA. Quantized velocities at low myosin densities in an in vitro motility assay Nature. 352: 307-311. PMID 1852205 DOI: 10.1038/352307A0  0.658
1990 Egelhoff TT, Manstein DJ, Spudich JA. Complementation of myosin null mutants in Dictyostelium discoideum by direct functional selection Developmental Biology. 137: 359-367. PMID 2406175 DOI: 10.1016/0012-1606(90)90260-P  0.322
1990 Fukui Y, De Lozanne A, Spudich JA. Structure and function of the cytoskeleton of a Dictyostelium myosin-defective mutant Journal of Cell Biology. 110: 367-378. PMID 2404992 DOI: 10.1083/Jcb.110.2.367  0.4
1990 O'Halloran TJ, Ravid S, Spudich JA. Expression of Dictyostelium myosin tail segments in Escherichia coli: Domains required for assembly and phosphorylation Journal of Cell Biology. 110: 63-70. PMID 2404023 DOI: 10.1083/Jcb.110.1.63  0.411
1990 O'Halloran TJ, Spudich JA. Genetically engineered truncated myosin in Dictyostelium: The carboxyl-terminal regulatory domain is not required for the developmental cycle Proceedings of the National Academy of Sciences of the United States of America. 87: 8110-8114. PMID 2236024 DOI: 10.1073/Pnas.87.20.8110  0.406
1990 Titus MA, Warrick HM, Spudich JA. Molecular genetics: a key to the cytoskeleton's closet. Current Opinion in Cell Biology. 2: 116-20. PMID 2183835 DOI: 10.1016/S0955-0674(05)80041-9  0.535
1990 Toyoshima YY, Kron SJ, Spudich JA. The myosin step size: Measurement of the unit displacement per ATP hydrolyzed in an in vitro assay Proceedings of the National Academy of Sciences of the United States of America. 87: 7130-7134. PMID 2144900 DOI: 10.1073/Pnas.87.18.7130  0.659
1990 Uyeda TQP, Kron SJ, Spudich JA. Myosin step size. Estimation from slow sliding movement of actin over low densities of heavy meromyosin Journal of Molecular Biology. 214: 699-710. PMID 2143785 DOI: 10.1016/0022-2836(90)90287-V  0.661
1990 Schwyter DH, Kron SJ, Toyoshima YY, Spudich JA, Reisler E. Subtilisin cleavage of actin inhibits in vitro sliding movement of actin filaments over myosin Journal of Cell Biology. 111: 465-470. PMID 2143196 DOI: 10.1083/Jcb.111.2.465  0.64
1990 Ruppel KM, Egelhoff TT, Spudich JA. Purification of a functional recombinant myosin fragment from Dictyostelium discoideum Annals of the New York Academy of Sciences. 582: 147-155. PMID 2141452 DOI: 10.1111/J.1749-6632.1990.Tb21675.X  0.345
1989 Pasternak C, Spudich JA, Elson EL. Capping of surface receptors and concomitant cortical tension are generated by conventional myosin Nature. 341: 549-551. PMID 2797182 DOI: 10.1038/341549A0  0.372
1989 Pasternak C, Flicker PF, Ravid S, Spudich JA. Intermolecular versus intramolecular interactions of Dictyostelium myosin: possible regulation by heavy chain phosphorylation. The Journal of Cell Biology. 109: 203-10. PMID 2745547 DOI: 10.1083/Jcb.109.1.203  0.441
1989 Manstein DJ, Titus MA, De Lozanne A, Spudich JA. Gene replacement in Dictyostelium: generation of myosin null mutants. The Embo Journal. 8: 923-32. PMID 2721503 DOI: 10.1002/J.1460-2075.1989.Tb03453.X  0.548
1989 Toyoshima YY, Toyoshima C, Spudich JA. Bidirectional movement of actin filaments along tracks of myosin heads Nature. 341: 154-156. PMID 2674720 DOI: 10.1038/341154A0  0.449
1989 Nachmias VT, Fukui Y, Spudich JA. Chemoattractant-elicited translocation of myosin in motile Dictyostelium Cell Motility and the Cytoskeleton. 13: 158-169. PMID 2550149 DOI: 10.1002/Cm.970130304  0.357
1989 Manstein DJ, Ruppel KM, Spudich JA. Expression and characterization of a functional myosin head fragment in Dictyostelium discoideum Science. 246: 656-658. PMID 2530629 DOI: 10.1126/Science.2530629  0.489
1989 Titus MA, Warrick HM, Spudich JA. Multiple actin-based motor genes in Dictyostelium. Cell Regulation. 1: 55-63. PMID 2519618 DOI: 10.1091/Mbc.1.1.55  0.641
1988 Curmi PM, Stone DB, Schneider DK, Spudich JA, Mendelson RA. Comparison of the structure of myosin subfragment 1 bound to actin and free in solution. A neutron scattering study using actin made "invisible" by deuteration. Journal of Molecular Biology. 203: 781-98. PMID 3062180 DOI: 10.1016/0022-2836(88)90209-4  0.375
1988 McNally EM, Goodwin EB, Spudich JA, Leinwand LA. Coexpression and assembly of myosin heavy chain and myosin light chain in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 85: 7270-7273. PMID 3050991 DOI: 10.1073/Pnas.85.19.7270  0.346
1988 Wessels D, Soll DR, Knecht D, Loomis WF, De Lozanne A, Spudich J. Cell motility and chemotaxis in Dictyostelium amebae lacking myosin heavy chain. Developmental Biology. 128: 164-77. PMID 2838348 DOI: 10.1016/0012-1606(88)90279-5  0.341
1988 Peters DJ, Knecht DA, Loomis WF, De Lozanne A, Spudich J, Van Haastert PJ. Signal transduction, chemotaxis, and cell aggregation in Dictyostelium discoideum cells without myosin heavy chain. Developmental Biology. 128: 158-63. PMID 2838347 DOI: 10.1016/0012-1606(88)90278-3  0.352
1987 Spudich JA. Chapter 1 Introductory Remarks and Some Biochemical Considerations Methods in Cell Biology. 28: 3-8. PMID 3600410 DOI: 10.1016/S0091-679X(08)61634-9  0.359
1987 De Lozanne A, Spudich JA. Disruption of the Dictyostelium myosin heavy chain gene by homologous recombination Science. 236: 1086-1091. PMID 3576222 DOI: 10.1126/Science.3576222  0.347
1987 Hynes TR, Block SM, White BT, Spudich JA. Movement of myosin fragments in vitro: domains involved in force production. Cell. 48: 953-63. PMID 3548997 DOI: 10.1016/0092-8674(87)90704-5  0.46
1987 De Lozanne A, Berlot CH, Leinwand LA, Spudich JA. Expression in Escherichia coli of a functional Dictyostelium myosin tail fragment Journal of Cell Biology. 105: 2999-3005. PMID 3320060 DOI: 10.1083/Jcb.105.6.2999  0.431
1987 Warrick HM, Spudich JA. Myosin structure and function in cell motility Annual Review of Cell Biology. 3: 379-421. PMID 3318880 DOI: 10.1146/Annurev.Cb.03.110187.002115  0.377
1987 Griffith LM, Downs SM, Spudich JA. Myosin light chain kinase and myosin light chain phosphatase from Dictyostelium: effects of reversible phosphorylation on myosin structure and function. The Journal of Cell Biology. 104: 1309-23. PMID 3032987 DOI: 10.1083/Jcb.104.5.1309  0.347
1987 Toyoshima YY, Kron SJ, McNally EM, Niebling KR, Toyoshima C, Spudich JA. Myosin subfragment-1 is sufficient to move actin filaments in vitro Nature. 328: 536-539. PMID 2956522 DOI: 10.1038/328536A0  0.67
1986 Sheetz MP, Block SM, Spudich JA. Myosin movement in vitro: a quantitative assay using oriented actin cables from Nitella. Methods in Enzymology. 134: 531-44. PMID 3821577 DOI: 10.1016/0076-6879(86)34118-1  0.41
1986 Warrick HM, De Lozanne A, Leinwand LA, Spudich JA. Conserved protein domains in a myosin heavy chain gene from Dictyostelium discoideum Proceedings of the National Academy of Sciences of the United States of America. 83: 9433-9437. PMID 3540939 DOI: 10.1073/Pnas.83.24.9433  0.396
1986 Kron SJ, Spudich JA. Fluorescent actin filaments move on myosin fixed to a glass surface Proceedings of the National Academy of Sciences of the United States of America. 83: 6272-6276. PMID 3462694 DOI: 10.1073/Pnas.83.17.6272  0.663
1985 Flicker PF, Peltz G, Sheetz MP, Parham P, Spudich JA. Site-specific inhibition of myosin-mediated motility in vitro by monoclonal antibodies. The Journal of Cell Biology. 100: 1024-30. PMID 3980577 DOI: 10.1083/Jcb.100.4.1024  0.343
1985 Spudich JA, Kron SJ, Sheetz MP. Movement of myosin-coated beads on oriented filaments reconstituted from purified actin Nature. 315: 584-586. PMID 3925346 DOI: 10.1038/315584A0  0.675
1985 DeLozanne A, Lewis M, Spudich JA, Leinwand LA. Cloning and characterization of a nonmuscle myosin heavy chain cDNA Proceedings of the National Academy of Sciences of the United States of America. 82: 6807-6810. PMID 3901008 DOI: 10.1073/Pnas.82.20.6807  0.318
1985 Sellers JR, Spudich JA, Sheetz MP. Light chain phosphorylation regulates the movement of smooth muscle myosin on actin filaments Journal of Cell Biology. 101: 1897-1902. PMID 3840488 DOI: 10.1083/Jcb.101.5.1897  0.404
1985 Peltz G, Spudich JA, Parham P. Monoclonal antibodies against seven sites on the head and tail of Dictyostelium myosin. The Journal of Cell Biology. 100: 1016-23. PMID 2579955 DOI: 10.1083/Jcb.100.4.1016  0.386
1984 Sheetz MP, Spudich JA. Movement of myosin-coated structures on actin cables. Cell Motility. 3: 485-9. PMID 6661767 DOI: 10.1002/CM.970030515  0.319
1984 Sheetz MP, Chasan R, Spudich JA. ATP-dependent movement of myosin in vitro: characterization of a quantitative assay. The Journal of Cell Biology. 99: 1867-71. PMID 6490724 DOI: 10.1083/Jcb.99.5.1867  0.432
1984 Giffard RG, Weeds AG, Spudich JA. Ca2+-dependent binding of severin to actin: a one-to-one complex is formed. The Journal of Cell Biology. 98: 1796-803. PMID 6427234 DOI: 10.1083/Jcb.98.5.1796  0.65
1984 Simpson PA, Spudich JA, Parham P. Monoclonal antibodies prepared against Dictyostelium actin: characterization and interactions with actin. The Journal of Cell Biology. 99: 287-95. PMID 6203918 DOI: 10.1083/Jcb.99.1.287  0.432
1983 Sheetz MP, Spudich JA. Movement of myosin-coated fluorescent beads on actin cables in vitro. Nature. 303: 31-5. PMID 6682486 DOI: 10.1038/303031A0  0.436
1983 Giffard RG, Spudich JA, Spudich A. Ca2+-sensitive isolation of a cortical actin matrix from Dictyostelium amoebae. Journal of Muscle Research and Cell Motility. 4: 115-31. PMID 6404931 DOI: 10.1007/Bf00711962  0.598
1982 Pardee JD, Simpson PA, Stryer L, Spudich JA. Actin filaments undergo limited subunit exchange in physiological salt conditions. The Journal of Cell Biology. 94: 316-24. PMID 7202009 DOI: 10.1083/Jcb.94.2.316  0.421
1982 Pardee JD, Spudich JA. Purification of muscle actin. Methods in Cell Biology. 24: 271-89. PMID 7098993 DOI: 10.1016/S0091-679X(08)60661-5  0.386
1982 Spudich JA, Kuczmarski ER, Pardee JD, Simpson PA, Yamamoto K, Stryer L. Control of assembly of Dictyostelium myosin and actin filaments. Cold Spring Harbor Symposia On Quantitative Biology. 46: 553-61. PMID 6955100 DOI: 10.1101/Sqb.1982.046.01.051  0.413
1982 Yamamoto K, Pardee JD, Reidler J, Stryer L, Spudich JA. Mechanism of interaction of Dictyostelium severin with actin filaments. The Journal of Cell Biology. 95: 711-9. PMID 6897549 DOI: 10.1083/Jcb.95.3.711  0.442
1982 Spudich JA, Pardee JD, Simpson PA, Yamamoto K, Kuczmarski ER, Stryer L. Actin and myosin: control of filament assembly. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 299: 247-61. PMID 6129660 DOI: 10.1098/Rstb.1982.0130  0.462
1982 Spudich A, Greenberg Giffard R, Spudich JA. Molecular aspects of cortical actin filament formation upon fertilization Cell Differentiation. 11: 281-284. DOI: 10.1016/0045-6039(82)90036-7  0.388
1981 Taylor DL, Reidler J, Spudich JA, Stryer L. Detection of actin assembly by fluorescence energy transfer. The Journal of Cell Biology. 89: 362-7. PMID 6894758 DOI: 10.1083/Jcb.89.2.362  0.396
1980 Mabuchi I, Spudich JA. Purification and properties of soluble actin from sea urchin eggs. Journal of Biochemistry. 87: 785-802. PMID 6893042 DOI: 10.1093/Oxfordjournals.Jbchem.A132808  0.397
1979 Brown S, Spudich J. Cytochalasin inhibits the rate of elongation of actin filament fragments Journal of Cell Biology. 83: 657-662. PMID 574873 DOI: 10.1083/Jcb.83.3.657  0.36
1979 Spudich JA, Amos LA. Structure of actin filament bundles from microvilli of sea urchin eggs. Journal of Molecular Biology. 129: 319-31. PMID 573333 DOI: 10.1016/0022-2836(79)90285-7  0.425
1977 Brown S, Levinson W, Spudich JA. Cytoskeletal elements of chick embryo fibroblasts revealed by detergent extraction. Journal of Supramolecular Structure. 5: 119-30. PMID 1034175 DOI: 10.1002/Jss.400050203  0.34
1977 Rubenstein PA, Spudich JA. Actin microheterogeneity in chick embryo fibroblasts Proceedings of the National Academy of Sciences of the United States of America. 74: 120-123. PMID 264664 DOI: 10.1073/Pnas.74.1.120  0.378
1977 Clarke M, Spudich JA. Nonmuscle contractile proteins: the role of actin and myosin in cell motility and shape determination. Annual Review of Biochemistry. 46: 797-822. PMID 143236 DOI: 10.1146/Annurev.Bi.46.070177.004053  0.457
1975 Spudich JA, Clarke M. The contractile proteins of Dictyostelium discoideum. Journal of Supramolecular Structure. 2: 150-62. PMID 4280006 DOI: 10.1002/Jss.400020209  0.443
1975 Clarke M, Schatten G, Mazia D, Spudich JA. Visualization of actin fibers associated with the cell membrane in amoebae of Dictyostelium discoideum. Proceedings of the National Academy of Sciences of the United States of America. 72: 1758-62. PMID 1057168 DOI: 10.1073/Pnas.72.5.1758  0.347
1974 Clarke M, Spudich JA. Biochemical and structural studies of actomyosin-like proteins from non-muscle cells. Isolation and characterization of myosin from amoebae of Dictyostelium discoideum. Journal of Molecular Biology. 86: 209-22. PMID 4278009 DOI: 10.1016/0022-2836(74)90013-8  0.42
1972 Spudich JA, Huxley HE, Finch JT. Regulation of skeletal muscle contraction. II. Structural studies of the interaction of the tropomyosin-troponin complex with actin. Journal of Molecular Biology. 72: 619-32. PMID 4349760 DOI: 10.1016/0022-2836(72)90180-5  0.433
1969 Bonsen PP, Spudich JA, Nelson DL, Kornberg A. Biochemical studies of bacterial sporulation and germination. XII. A sulfonic acid as a major sulfur compound of Bacillus subtilis spores. Journal of Bacteriology. 98: 62-8. PMID 4977690 DOI: 10.1128/Jb.98.1.62-68.1969  0.555
1969 Spudich JA, Kornberg A. Biochemical studies of bacterial sporulation and germination. 13. Adenylate kinase of vegetative cells and spores of Bacillus subtilis. Journal of Bacteriology. 98: 69-74. PMID 4976471 DOI: 10.1128/Jb.98.1.69-74.1969  0.491
1968 Spudich JA, Kornberg A. Biochemical studies of bacterial sporulation and germaination. VII. Protein turnover during sporulation of Bacillus subtilis. The Journal of Biological Chemistry. 243: 4600-5. PMID 4971699  0.399
1968 Spudich JA, Kornberg A. Biochemical studies of bacterial sporulation and germination. VI. Origin of spore core and coat proteins. The Journal of Biological Chemistry. 243: 4588-99. PMID 4971698  0.394
1968 Kornberg A, Spudich JA, Nelson DL, Deutscher MP. Origin of proteins in sporulation. Annual Review of Biochemistry. 37: 51-78. PMID 4875719 DOI: 10.1146/Annurev.Bi.37.070168.000411  0.568
Show low-probability matches.