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Matthew Figley, Ph.D. - Publications

Affiliations: 
2010-2012 Developmental Biology University of Pennsylvania, Philadelphia, PA, United States 
 2012-2015 Genetics Stanford University, Palo Alto, CA 
 2015- Developmental Biology Washington University, Saint Louis, St. Louis, MO 
Area:
neurodegeneration
Website:
https://scholar.google.com/citations?user=oLn6KxcAAAAJ&hl=en
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11 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wu T, Zhu J, Strickland A, Ko KW, Sasaki Y, Dingwall CB, Yamada Y, Figley MD, Mao X, Neiner A, Bloom AJ, DiAntonio A, Milbrandt J. Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss. Cell Reports. 37: 109872. PMID 34686345 DOI: 10.1016/j.celrep.2021.109872  0.606
2021 DiAntonio A, Milbrandt J, Figley MD. The SARM1 TIR NADase: Mechanistic Similarities to Bacterial Phage Defense and Toxin-Antitoxin Systems. Frontiers in Immunology. 12: 752898. PMID 34630431 DOI: 10.3389/fimmu.2021.752898  0.536
2021 Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, et al. SARM1 is a metabolic sensor activated by an increased NMN/NAD ratio to trigger axon degeneration. Neuron. PMID 33657413 DOI: 10.1016/j.neuron.2021.02.009  0.578
2021 Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J. Multiple domain interfaces mediate SARM1 autoinhibition. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33468661 DOI: 10.1073/pnas.2023151118  0.568
2020 Figley MD, DiAntonio A. The SARM1 axon degeneration pathway: control of the NAD metabolome regulates axon survival in health and disease. Current Opinion in Neurobiology. 63: 59-66. PMID 32311648 DOI: 10.1016/j.conb.2020.02.012  0.566
2020 Sasaki Y, Engber TM, Hughes RO, Figley MD, Wu T, Bosanac T, Devraj R, Milbrandt J, Krauss R, DiAntonio A. cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons. Experimental Neurology. 113252. PMID 32087251 DOI: 10.1016/J.Expneurol.2020.113252  0.586
2015 Figley MD, Gitler AD. Neurodegeneration: A Leg Up on TDP-43. Current Biology : Cb. 25: R728-31. PMID 26294190 DOI: 10.1016/J.Cub.2015.06.064  0.608
2014 Figley MD, Bieri G, Kolaitis RM, Taylor JP, Gitler AD. Profilin 1 associates with stress granules and ALS-linked mutations alter stress granule dynamics. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8083-97. PMID 24920614 DOI: 10.1523/JNEUROSCI.0543-14.2014  0.575
2014 Figley MD, Thomas A, Gitler AD. Evaluating noncoding nucleotide repeat expansions in amyotrophic lateral sclerosis. Neurobiology of Aging. 35: 936.e1-4. PMID 24269018 DOI: 10.1016/J.Neurobiolaging.2013.09.024  0.565
2013 Figley MD, Gitler AD. Yeast genetic screen reveals novel therapeutic strategy for ALS. Rare Diseases (Austin, Tex.). 1: e24420. PMID 25002991 DOI: 10.4161/rdis.24420  0.666
2012 Armakola M, Higgins MJ, Figley MD, Barmada SJ, Scarborough EA, Diaz Z, Fang X, Shorter J, Krogan NJ, Finkbeiner S, Farese RV, Gitler AD. Inhibition of RNA lariat debranching enzyme suppresses TDP-43 toxicity in ALS disease models. Nature Genetics. 44: 1302-9. PMID 23104007 DOI: 10.1038/Ng.2434  0.491
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