| Year |
Citation |
Score |
| 2023 |
Dangerfield TL, Johnson KA. Design and interpretation of experiments to establish enzyme pathway and define the role of conformational changes in enzyme specificity. Methods in Enzymology. 685: 461-492. PMID 37245912 DOI: 10.1016/bs.mie.2023.03.018 |
0.304 |
|
| 2022 |
Dangerfield TL, Johnson KA. Kinetics of DNA strand transfer between polymerase and proofreading exonuclease active sites regulates error correction during high fidelity replication. The Journal of Biological Chemistry. 102744. PMID 36436560 DOI: 10.1016/j.jbc.2022.102744 |
0.303 |
|
| 2022 |
Dangerfield TL, Kirmizialtin S, Johnson KA. Substrate specificity and proposed structure of the proofreading complex of T7 DNA polymerase. The Journal of Biological Chemistry. 101627. PMID 35074426 DOI: 10.1016/j.jbc.2022.101627 |
0.302 |
|
| 2021 |
Dangerfield TL, Kirmizialtin S, Johnson KA. Conformational dynamics during misincorporation and mismatch extension defined using a DNA polymerase with a fluorescent artificial amino acid. The Journal of Biological Chemistry. 298: 101451. PMID 34838820 DOI: 10.1016/j.jbc.2021.101451 |
0.351 |
|
| 2021 |
Fagan SP, Mukherjee P, Jaremko WJ, Nelson-Rigg R, Wilson RC, Dangerfield TL, Johnson KA, Lahiri I, Pata JD. Pyrophosphate release acts as a kinetic checkpoint during high-fidelity DNA replication by the Staphylococcus aureus replicative polymerase PolC. Nucleic Acids Research. PMID 34302475 DOI: 10.1093/nar/gkab613 |
0.321 |
|
| 2020 |
Dangerfield TL, Johnson KA. Conformational dynamics during high fidelity DNA replication and translocation defined using a DNA polymerase with a fluorescent artificial amino acid. The Journal of Biological Chemistry. PMID 33273013 DOI: 10.1074/jbc.RA120.016617 |
0.356 |
|
| 2020 |
Villalba B, Johnson KA. Rate-limiting pyrophosphate release by Hepatitis C Virus polymerase NS5B improves fidelity. The Journal of Biological Chemistry. PMID 32938715 DOI: 10.1074/Jbc.Ra120.015394 |
0.345 |
|
| 2020 |
Liu MS, Gong S, Yu HH, Jung K, Johnson KA, Taylor DW. Engineered CRISPR/Cas9 enzymes improve discrimination by slowing DNA cleavage to allow release of off-target DNA. Nature Communications. 11: 3576. PMID 32681021 DOI: 10.1038/S41467-020-17411-1 |
0.382 |
|
| 2020 |
Villalba B, Li J, Johnson KA. Resistance to excision determines efficiency of inhibition of hepatitis C virus RNA-dependent RNA polymerase by nucleotide analogs including sofosbuvir. The Journal of Biological Chemistry. PMID 32457046 DOI: 10.1074/Jbc.Ra120.013422 |
0.328 |
|
| 2020 |
Wang H, Huang N, Dangerfield T, Johnson KA, Gao J, Elber R. Exploring the Reaction Mechanism of HIV RT with a Nucleotide Substrate. The Journal of Physical Chemistry. B. PMID 32364738 DOI: 10.1021/Acs.Jpcb.0C02632 |
0.424 |
|
| 2019 |
Meadows MK, Sun X, Kolesnichenko IV, Hinson CM, Johnson KA, Anslyn EV. Mechanistic studies of a "Declick" reaction. Chemical Science. 10: 8817-8824. PMID 31803455 DOI: 10.1039/C9Sc00690G |
0.335 |
|
| 2019 |
Liu MS, Gong S, Yu HH, Taylor DW, Johnson KA. Kinetic characterization of Cas9 enzymes. Methods in Enzymology. 616: 289-311. PMID 30691648 DOI: 10.1016/Bs.Mie.2018.10.022 |
0.315 |
|
| 2019 |
Johnson KA. New standards for collecting and fitting steady state kinetic data. Beilstein Journal of Organic Chemistry. 15: 16-29. PMID 30680035 DOI: 10.3762/Bjoc.15.2 |
0.31 |
|
| 2018 |
Kwiatkowska J, Wroblewska Z, Johnson KA, Olejniczak M. The binding of Class II sRNA MgrR to two different sites on matchmaker protein Hfq enables efficient competition for Hfq and annealing to regulated mRNAs. Rna (New York, N.Y.). PMID 30217864 DOI: 10.1261/Rna.067777.118 |
0.315 |
|
| 2018 |
Gong S, Yu HH, Johnson KA, Taylor DW. DNA Unwinding Is the Primary Determinant of CRISPR-Cas9 Activity. Cell Reports. 22: 359-371. PMID 29320733 DOI: 10.1016/J.Celrep.2017.12.041 |
0.392 |
|
| 2018 |
Gong S, Yu HH, Johnson KA, Taylor DW. DNA Unwinding is the Primary Determinant of CRISPR-Cas9 Specificity Biophysical Journal. 114: 251a. DOI: 10.1016/J.Bpj.2017.11.1395 |
0.34 |
|
| 2017 |
Atiş M, Johnson KA, Elber R. Pyrophosphate Release in the Protein HIV Reverse Transcriptase. The Journal of Physical Chemistry. B. PMID 28926712 DOI: 10.1021/Acs.Jpcb.7B08320 |
0.366 |
|
| 2017 |
Qian Y, Johnson KA. The human mitochondrial single strand DNA binding protein displays distinct kinetics and thermodynamics of DNA binding and exchange. The Journal of Biological Chemistry. PMID 28615444 DOI: 10.1074/Jbc.M117.791392 |
0.435 |
|
| 2017 |
Huddleston JP, Wang SC, Johnson KA, Whitman CP. Resolution of the uncertainty in the kinetic mechanism for the trans-3-Chloroacrylic acid dehalogenase-catalyzed reaction. Archives of Biochemistry and Biophysics. PMID 28499743 DOI: 10.1016/J.Abb.2017.05.004 |
0.341 |
|
| 2017 |
Li A, Ziehr JL, Johnson KA. A New General Method for Simultaneous Fitting of Temperature- and Concentration-Dependence of Reaction Rates Yields Kinetic and Thermodynamic Parameters for HIV Reverse Transcriptase Specificity. The Journal of Biological Chemistry. PMID 28255091 DOI: 10.1074/Jbc.M116.760827 |
0.378 |
|
| 2016 |
Li A, Gong S, Johnson KA. Rate-limiting Pyrophosphate Release by HIV Reverse Transcriptase Improves Fidelity. The Journal of Biological Chemistry. PMID 27777304 DOI: 10.1074/Jbc.M116.753152 |
0.398 |
|
| 2016 |
Li A, Li J, Johnson KA. HIV-1 Reverse Transcriptase Polymerase and RNase H Active Sites Work Simultaneously and Independently. The Journal of Biological Chemistry. PMID 27777303 DOI: 10.1074/Jbc.M116.753160 |
0.406 |
|
| 2016 |
Deredge D, Li J, Johnson KA, Wintrode PL. Hydrogen/Deuterium Exchange Kinetics Demonstrate Long Range Allosteric Effects of Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-dependent RNA Polymerase. The Journal of Biological Chemistry. PMID 27006396 DOI: 10.1074/Jbc.M115.708370 |
0.351 |
|
| 2016 |
Li J, Johnson KA. Thumb Site 2 Inhibitors of Hepatitis C Viral RNA-Dependent RNA Polymerase Allosterically Block the Transition from Initiation to Elongation. The Journal of Biological Chemistry. PMID 26851276 DOI: 10.1016/J.Bpj.2015.11.1130 |
0.36 |
|
| 2016 |
Gong S, Johnson K. The Effect of Magnesium Ion Concentration on the Nucleotide Specificity and Fidelity of HIV-1 Reverse Transcriptase Biophysical Journal. 110: 547a. DOI: 10.1016/J.Bpj.2015.11.2927 |
0.363 |
|
| 2016 |
Li A, Johnson K. Rate-Limiting Pyrophosphate Release by HIV Reverse Transcriptase and its Effect on Enzyme Specificity Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.165 |
0.435 |
|
| 2015 |
Kirmizialtin S, Johnson KA, Elber R. Enzyme Selectivity of HIV Reverse Transcriptase: Conformations, Ligands, and Free Energy Partition. The Journal of Physical Chemistry. B. PMID 26225641 DOI: 10.1016/J.Bpj.2015.11.410 |
0.376 |
|
| 2015 |
Ahmad S, Thulasingam M, Palombo I, Daley DO, Johnson KA, Morgenstern R, Haeggström JZ, Rinaldo-Matthis A. Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity. Biochimica Et Biophysica Acta. 1854: 1365-1371. PMID 26066610 DOI: 10.1016/J.Bbapap.2015.06.003 |
0.337 |
|
| 2015 |
Qian Y, Ziehr JL, Johnson KA. Alpers disease mutations in human DNA polymerase gamma cause catalytic defects in mitochondrial DNA replication by distinct mechanisms. Frontiers in Genetics. 6: 135. PMID 25914719 DOI: 10.3389/Fgene.2015.00135 |
0.41 |
|
| 2015 |
Deredge DJ, Johnson K, Wintrode P. Thumb II Site Inhibitor Allosterically Suppresses the Dynamics of HCV RNA-Dependent RNA Polymerase Biophysical Journal. 108: 529a. DOI: 10.1016/J.Bpj.2014.11.2900 |
0.333 |
|
| 2014 |
Qian Y, Kachroo AH, Yellman CM, Marcotte EM, Johnson KA. Yeast cells expressing the human mitochondrial DNA polymerase reveal correlations between polymerase fidelity and human disease progression. The Journal of Biological Chemistry. 289: 5970-85. PMID 24398692 DOI: 10.1074/Jbc.M113.526418 |
0.336 |
|
| 2014 |
Seckler J, Kirmizialtin S, Johnson KA, Grossfield A. Covariance Ration Analysis of Molecular Dynamics Trajectories of Hiv-1 Reverse Transcriptase Biophysical Journal. 106: 653a. DOI: 10.1016/J.Bpj.2013.11.3611 |
0.32 |
|
| 2013 |
Johnson KA. A century of enzyme kinetic analysis, 1913 to 2013. Febs Letters. 587: 2753-66. PMID 23850893 DOI: 10.1016/J.Febslet.2013.07.012 |
0.335 |
|
| 2013 |
Jin Z, Leveque V, Ma H, Johnson KA, Klumpp K. NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase. Proceedings of the National Academy of Sciences of the United States of America. 110: E348-57. PMID 23307808 DOI: 10.1073/Pnas.1214924110 |
0.338 |
|
| 2013 |
Li A, Johnson KA. AZT Drug Resistance Conferred by a Dipeptide Insertion in the Fingers of HIV-1 Reverse Transcriptase Involves Multiple Mechanisms Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.456 |
0.386 |
|
| 2013 |
Qian Y, Ziehr JL, Johnson KA. Towards Efficient Reconstitution of the Human Mitochondrial DNA Replication Complex Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.448 |
0.425 |
|
| 2012 |
Huddleston JP, Schroeder GK, Johnson KA, Whitman CP. A pre-steady state kinetic analysis of the αY60W mutant of trans-3-chloroacrylic acid dehalogenase: implications for the mechanism of the wild-type enzyme. Biochemistry. 51: 9420-35. PMID 23110338 DOI: 10.1021/Bi3010686 |
0.371 |
|
| 2012 |
Johnson KA. Biochemistry: DNA replication caught in the act. Nature. 487: 177-8. PMID 22785309 DOI: 10.1038/487177A |
0.401 |
|
| 2012 |
Heidebrecht T, Fish A, von Castelmur E, Johnson KA, Zaccai G, Borst P, Perrakis A. Binding of the J-binding protein to DNA containing glucosylated hmU (base J) or 5-hmC: evidence for a rapid conformational change upon DNA binding. Journal of the American Chemical Society. 134: 13357-65. PMID 22775585 DOI: 10.1021/Ja303423T |
0.428 |
|
| 2012 |
Kirmizialtin S, Nguyen V, Johnson KA, Elber R. How conformational dynamics of DNA polymerase select correct substrates: experiments and simulations. Structure (London, England : 1993). 20: 618-27. PMID 22483109 DOI: 10.1016/J.Str.2012.02.018 |
0.396 |
|
| 2012 |
Jin Z, Leveque V, Ma H, Johnson KA, Klumpp K. Assembly, purification, and pre-steady-state kinetic analysis of active RNA-dependent RNA polymerase elongation complex. The Journal of Biological Chemistry. 287: 10674-83. PMID 22303022 DOI: 10.1074/Jbc.M111.325530 |
0.368 |
|
| 2012 |
Kirmizialtin S, Elber R, Johnson KA. Antlion Strategy for Enzyme Specificity Biophysical Journal. 102: 273a. DOI: 10.1016/J.Bpj.2011.11.1502 |
0.357 |
|
| 2011 |
Holman GG, Zewail-Foote M, Smith AR, Johnson KA, Iverson BL. A sequence-specific threading tetra-intercalator with an extremely slow dissociation rate constant. Nature Chemistry. 3: 875-81. PMID 22024884 DOI: 10.1038/Nchem.1151 |
0.414 |
|
| 2011 |
Michaelis L, Menten ML, Johnson KA, Goody RS. The original Michaelis constant: translation of the 1913 Michaelis-Menten paper. Biochemistry. 50: 8264-9. PMID 21888353 DOI: 10.1021/Bi201284U |
0.348 |
|
| 2011 |
Estep PA, Johnson KA. Effect of the Y955C mutation on mitochondrial DNA polymerase nucleotide incorporation efficiency and fidelity. Biochemistry. 50: 6376-86. PMID 21696159 DOI: 10.1021/Bi200280R |
0.387 |
|
| 2011 |
Kellinger MW, Johnson KA. Role of induced fit in limiting discrimination against AZT by HIV reverse transcriptase. Biochemistry. 50: 5008-15. PMID 21548586 DOI: 10.1021/Bi200204M |
0.407 |
|
| 2011 |
Jin Z, Deval J, Johnson KA, Swinney DC. Characterization of the elongation complex of dengue virus RNA polymerase: assembly, kinetics of nucleotide incorporation, and fidelity. The Journal of Biological Chemistry. 286: 2067-77. PMID 21078673 DOI: 10.1074/Jbc.M110.162685 |
0.393 |
|
| 2011 |
Jin Z, Johnson KA. Role of a GAG hinge in the nucleotide-induced conformational change governing nucleotide specificity by T7 DNA polymerase. The Journal of Biological Chemistry. 286: 1312-22. PMID 20978284 DOI: 10.1074/Jbc.M110.156737 |
0.421 |
|
| 2011 |
Batabyal D, McKenzie JL, Johnson KA. Role of Histidine-932 of Human Mitochondrial DNA Polymerase in Nucleotide Discrimination and Inherited Disease Biophysical Journal. 100: 2-7. DOI: 10.1016/J.Bpj.2010.12.1400 |
0.388 |
|
| 2011 |
Kellinger MW, Korlach J, Johnson KA. DNA Translocation Dynamics of HIV Reverse Transcriptase Revealed Through Single Molecule Kinetics of Nucleotide Binding Biophysical Journal. 100: 193a. DOI: 10.1016/J.Bpj.2010.12.1270 |
0.459 |
|
| 2010 |
Karnas E, Kim SK, Johnson KA, Sessler JL, Ohkubo K, Fukuzumi S. Stopped-flow kinetic analysis of the interaction of cyclo[8]pyrrole with anions. Journal of the American Chemical Society. 132: 16617-22. PMID 21043496 DOI: 10.1021/Ja107471X |
0.301 |
|
| 2010 |
Batabyal D, McKenzie JL, Johnson KA. Role of histidine 932 of the human mitochondrial DNA polymerase in nucleotide discrimination and inherited disease. The Journal of Biological Chemistry. 285: 34191-201. PMID 20685647 DOI: 10.1074/Jbc.M110.156182 |
0.391 |
|
| 2010 |
Lee YS, Johnson KA, Molineux IJ, Yin YW. A single mutation in human mitochondrial DNA polymerase Pol gammaA affects both polymerization and proofreading activities of only the holoenzyme. The Journal of Biological Chemistry. 285: 28105-16. PMID 20513922 DOI: 10.1074/Jbc.M110.122283 |
0.399 |
|
| 2010 |
Kellinger MW, Johnson KA. Nucleotide-dependent conformational change governs specificity and analog discrimination by HIV reverse transcriptase. Proceedings of the National Academy of Sciences of the United States of America. 107: 7734-9. PMID 20385846 DOI: 10.1073/Pnas.0913946107 |
0.398 |
|
| 2010 |
Johnson KA. The kinetic and chemical mechanism of high-fidelity DNA polymerases. Biochimica Et Biophysica Acta. 1804: 1041-8. PMID 20079883 DOI: 10.1016/J.Bbapap.2010.01.006 |
0.434 |
|
| 2010 |
Lee YS, Lee S, Demeler B, Molineux IJ, Johnson KA, Yin YW. Each monomer of the dimeric accessory protein for human mitochondrial DNA polymerase has a distinct role in conferring processivity. The Journal of Biological Chemistry. 285: 1490-9. PMID 19858216 DOI: 10.1074/Jbc.M109.062752 |
0.444 |
|
| 2010 |
Johnson KA. Thermodynamics of microtubule assembly. Biophysical Journal. 32: 443-5. PMID 19431387 DOI: 10.1016/S0006-3495(80)84975-7 |
0.309 |
|
| 2010 |
Kellinger MW, Johnson KA. Characterization of HIV-1 Reverse Transcriptase 3TC Specificity By Conformationally Sensitive Fluorescence Reveals New Insights Into the Kinetic Basis of Inhibitor Discrimination Biophysical Journal. 98: 71a. DOI: 10.1016/J.Bpj.2009.12.402 |
0.422 |
|
| 2010 |
Jin Z, Deval J, Johnson KA, Swinney DC. Pre-Steady-State Kinetic Analysis of the Elongation Mode of Dengue Virus RNA Polymerase Domain Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.2454 |
0.386 |
|
| 2009 |
Robertson BA, Schroeder GK, Jin Z, Johnson KA, Whitman CP. Pre-steady-state kinetic analysis of cis-3-chloroacrylic acid dehalogenase: analysis and implications. Biochemistry. 48: 11737-44. PMID 19856961 DOI: 10.1021/Bi901349Z |
0.381 |
|
| 2009 |
Johnson KA, Simpson ZB, Blom T. FitSpace explorer: an algorithm to evaluate multidimensional parameter space in fitting kinetic data. Analytical Biochemistry. 387: 30-41. PMID 19168024 DOI: 10.1016/J.Ab.2008.12.025 |
0.302 |
|
| 2009 |
Tsai YC, Jin Z, Johnson KA. Site-specific labeling of T7 DNA polymerase with a conformationally sensitive fluorophore and its use in detecting single-nucleotide polymorphisms. Analytical Biochemistry. 384: 136-44. PMID 18834851 DOI: 10.1016/J.Ab.2008.09.006 |
0.595 |
|
| 2008 |
Johnson KA. Role of induced fit in enzyme specificity: a molecular forward/reverse switch. The Journal of Biological Chemistry. 283: 26297-301. PMID 18544537 DOI: 10.1074/Jbc.R800034200 |
0.381 |
|
| 2008 |
Fowler JD, Brown JA, Johnson KA, Suo Z. Kinetic investigation of the inhibitory effect of gemcitabine on DNA polymerization catalyzed by human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 283: 15339-48. PMID 18378680 DOI: 10.1074/Jbc.M800310200 |
0.705 |
|
| 2008 |
Richards JD, Johnson KA, Liu H, McRobbie AM, McMahon S, Oke M, Carter L, Naismith JH, White MF. Structure of the DNA repair helicase hel308 reveals DNA binding and autoinhibitory domains. The Journal of Biological Chemistry. 283: 5118-26. PMID 18056710 DOI: 10.1074/Jbc.M707548200 |
0.412 |
|
| 2008 |
Hanes JW, Johnson KA. Exonuclease removal of dideoxycytidine (zalcitabine) by the human mitochondrial DNA polymerase. Antimicrobial Agents and Chemotherapy. 52: 253-8. PMID 17984232 DOI: 10.1128/Aac.00778-07 |
0.757 |
|
| 2008 |
Hanes JW, Johnson KA. Real-time measurement of pyrophosphate release kinetics. Analytical Biochemistry. 372: 125-7. PMID 17905190 DOI: 10.1016/J.Ab.2007.08.004 |
0.744 |
|
| 2008 |
Lee HR, Helquist SA, Kool ET, Johnson KA. Base pair hydrogen bonds are essential for proofreading selectivity by the human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 283: 14411-6. PMID 17650503 DOI: 10.1074/Jbc.M705006200 |
0.586 |
|
| 2008 |
Lee HR, Helquist SA, Kool ET, Johnson KA. Importance of hydrogen bonding for efficiency and specificity of the human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 283: 14402-10. PMID 17650502 DOI: 10.1074/Jbc.M705007200 |
0.596 |
|
| 2007 |
Hanes JW, Johnson KA. A novel mechanism of selectivity against AZT by the human mitochondrial DNA polymerase. Nucleic Acids Research. 35: 6973-83. PMID 17940100 DOI: 10.1093/Nar/Gkm695 |
0.747 |
|
| 2007 |
Lee HR, Johnson KA. Fidelity and processivity of reverse transcription by the human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 282: 31982-9. PMID 17711845 DOI: 10.1074/Jbc.M705392200 |
0.658 |
|
| 2007 |
Hanes JW, Zhu Y, Parris DS, Johnson KA. Enzymatic therapeutic index of acyclovir. Viral versus human polymerase gamma specificity. The Journal of Biological Chemistry. 282: 25159-67. PMID 17573351 DOI: 10.1074/Jbc.M703972200 |
0.748 |
|
| 2007 |
Jin Z, Johnson KA. Characterization of a T7 DNA Polymerase Mutant with a Completely Rate-limiting Conformational Change Step during Nucleotide Incorporation The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A657-A |
0.395 |
|
| 2006 |
Lee HR, Johnson KA. Fidelity of the human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 281: 36236-40. PMID 17005554 DOI: 10.1074/Jbc.M607964200 |
0.631 |
|
| 2006 |
Hanes JW, Thal DM, Johnson KA. Incorporation and replication of 8-oxo-deoxyguanosine by the human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 281: 36241-8. PMID 17005553 DOI: 10.1074/Jbc.M607965200 |
0.744 |
|
| 2006 |
Bhushan S, Johnson KA, Eneqvist T, Glaser E. Proteolytic mechanism of a novel mitochondrial and chloroplastic PreP peptidasome. Biological Chemistry. 387: 1087-90. PMID 16895479 DOI: 10.1515/Bc.2006.134 |
0.337 |
|
| 2006 |
Tsai YC, Johnson KA. A new paradigm for DNA polymerase specificity. Biochemistry. 45: 9675-87. PMID 16893169 DOI: 10.1021/Bi060993Z |
0.629 |
|
| 2005 |
Auerbach SD, Johnson KA. Alternating site ATPase pathway of rat conventional kinesin. The Journal of Biological Chemistry. 280: 37048-60. PMID 16118218 DOI: 10.1074/Jbc.M502984200 |
0.699 |
|
| 2005 |
Auerbach SD, Johnson KA. Kinetic effects of kinesin switch I and switch II mutations. The Journal of Biological Chemistry. 280: 37061-8. PMID 16118217 DOI: 10.1074/Jbc.M502985200 |
0.69 |
|
| 2005 |
Hanes JW, Johnson KA. Analysis of single nucleotide incorporation reactions by capillary electrophoresis. Analytical Biochemistry. 340: 35-40. PMID 15802127 DOI: 10.1016/J.Ab.2005.02.013 |
0.718 |
|
| 2004 |
Wang LZ, Kenyon GL, Johnson KA. Novel mechanism of inhibition of HIV-1 reverse transcriptase by a new non-nucleoside analog, KM-1. The Journal of Biological Chemistry. 279: 38424-32. PMID 15231830 DOI: 10.1074/Jbc.M406241200 |
0.648 |
|
| 2004 |
Feng JY, Murakami E, Zorca SM, Johnson AA, Johnson KA, Schinazi RF, Furman PA, Anderson KS. Relationship between antiviral activity and host toxicity: comparison of the incorporation efficiencies of 2',3'-dideoxy-5-fluoro-3'-thiacytidine-triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase. Antimicrobial Agents and Chemotherapy. 48: 1300-6. PMID 15047533 DOI: 10.1128/Aac.48.4.1300-1306.2004 |
0.64 |
|
| 2003 |
Lee H, Hanes J, Johnson KA. Toxicity of Nucleoside Analogues Used to Treat AIDS and the Selectivity of the Mitochondrial DNA Polymerase Biochemistry. 42: 14711-14719. PMID 14674745 DOI: 10.1021/Bi035596S |
0.775 |
|
| 2003 |
Murakami E, Feng JY, Lee H, Hanes J, Johnson KA, Anderson KS. Characterization of novel reverse transcriptase and other RNA-associated catalytic activities by human DNA polymerase γ: Importance in mitochondrial DNA replication Journal of Biological Chemistry. 278: 36403-36409. PMID 12857740 DOI: 10.1074/Jbc.M306236200 |
0.773 |
|
| 2003 |
Fraley AW, Chen D, Johnson K, McLaughlin LW. An HIV reverse transcriptase-selective nucleoside chain terminator Journal of the American Chemical Society. 125: 616-617. PMID 12526645 DOI: 10.1021/Ja020639Y |
0.387 |
|
| 2001 |
Johnson AA, Ray AS, Hanes J, Suo Z, Colacino JM, Anderson KS, Johnson KA. Toxicity of antiviral nucleoside analogs and the human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 276: 40847-57. PMID 11526116 DOI: 10.1074/Jbc.M106743200 |
0.797 |
|
| 2001 |
Johnson AA, Johnson KA. Exonuclease proofreading by human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 276: 38097-107. PMID 11477094 DOI: 10.1074/Jbc.M106046200 |
0.652 |
|
| 2001 |
Johnson AA, Johnson KA. Fidelity of nucleotide incorporation by human mitochondrial DNA polymerase. The Journal of Biological Chemistry. 276: 38090-6. PMID 11477093 DOI: 10.1074/Jbc.M106045200 |
0.636 |
|
| 2001 |
Feng JY, Johnson AA, Johnson KA, Anderson KS. Insights into the molecular mechanism of mitochondrial toxicity by AIDS drugs. The Journal of Biological Chemistry. 276: 23832-7. PMID 11328813 DOI: 10.1074/Jbc.M101156200 |
0.641 |
|
| 2000 |
Johnson AA, Tsai Yc, Graves SW, Johnson KA. Human mitochondrial DNA polymerase holoenzyme: reconstitution and characterization. Biochemistry. 39: 1702-8. PMID 10677218 DOI: 10.1021/Bi992104W |
0.743 |
|
| 1999 |
Lewis J, Johnson KA, Anderson KS. The catalytic mechanism of EPSP synthase revisited Biochemistry. 38: 7372-7379. PMID 10353849 DOI: 10.1021/Bi9830258 |
0.327 |
|
| 1999 |
Suo Z, Lippard SJ, Johnson KA. Single d(GpG)/cis-diammineplatinum(II) adduct-induced inhibition of DNA polymerization. Biochemistry. 38: 715-26. PMID 9888812 DOI: 10.1021/Bi981854N |
0.607 |
|
| 1998 |
Mandelkow E, Johnson KA. The structural and mechanochemical cycle of kinesin. Trends in Biochemical Sciences. 23: 429-33. PMID 9852761 DOI: 10.1016/S0968-0004(98)01278-X |
0.33 |
|
| 1998 |
Suo Z, Johnson KA. DNA secondary structure effects on DNA synthesis catalyzed by HIV-1 reverse transcriptase. The Journal of Biological Chemistry. 273: 27259-67. PMID 9765249 DOI: 10.1074/Jbc.273.42.27259 |
0.6 |
|
| 1998 |
Suo Z, Johnson KA. Selective inhibition of HIV-1 reverse transcriptase by an antiviral inhibitor, (R)-9-(2-Phosphonylmethoxypropyl)adenine. The Journal of Biological Chemistry. 273: 27250-8. PMID 9765248 DOI: 10.1074/Jbc.273.42.27250 |
0.604 |
|
| 1998 |
Graves SW, Johnson AA, Johnson KA. Expression, purification, and initial kinetic characterization of the large subunit of the human mitochondrial DNA polymerase. Biochemistry. 37: 6050-8. PMID 9558343 DOI: 10.1021/Bi972685U |
0.656 |
|
| 1998 |
Johnson KA. Advances in transient-state kinetics Current Opinion in Biotechnology. 9: 87-89. PMID 9503593 DOI: 10.1016/S0958-1669(98)80089-X |
0.309 |
|
| 1998 |
Moyer ML, Gilbert SP, Johnson KA. Pathway of ATP hydrolysis by monomeric and dimeric kinesin Biochemistry. 37: 800-813. PMID 9454569 DOI: 10.1021/Bi9711184 |
0.664 |
|
| 1998 |
Gilbert SP, Moyer ML, Johnson KA. Alternating site mechanism of the kinesin ATPase Biochemistry. 37: 792-799. PMID 9454568 DOI: 10.1021/Bi971117B |
0.668 |
|
| 1997 |
Suo Z, Johnson KA. RNA secondary structure switching during DNA synthesis catalyzed by HIV-1 reverse transcriptase. Biochemistry. 36: 14778-85. PMID 9398198 DOI: 10.1021/Bi971963M |
0.54 |
|
| 1997 |
Suo Z, Johnson KA. Effect of RNA secondary structure on RNA cleavage catalyzed by HIV-1 reverse transcriptase. Biochemistry. 36: 12468-76. PMID 9376351 DOI: 10.1021/Bi971218+ |
0.56 |
|
| 1997 |
Suo Z, Johnson KA. Effect of RNA secondary structure on the kinetics of DNA synthesis catalyzed by HIV-1 reverse transcriptase. Biochemistry. 36: 12459-67. PMID 9376350 DOI: 10.1021/Bi971217H |
0.61 |
|
| 1997 |
Hacker KJ, Johnson KA. A hexameric helicase encircles one DNA strand and excludes the other during DNA unwinding Biochemistry. 36: 14080-14087. PMID 9369480 DOI: 10.1021/Bi971644V |
0.39 |
|
| 1996 |
Brandis JW, Edwards SG, Johnson KA. Slow rate of phosphodiester bond formation accounts for the strong bias that taq DNA polymerase shows against 2′,3′-dideoxynucleotide terminators Biochemistry. 35: 2189-2200. PMID 8652560 DOI: 10.1021/Bi951682J |
0.468 |
|
| 1996 |
Moyer ML, Gilbert SP, Johnson KA. Purification and characterization of two monomeric kinesin constructs Biochemistry. 35: 6321-6329. PMID 8639576 DOI: 10.1021/Bi960017N |
0.623 |
|
| 1996 |
Spence RA, Anderson KS, Johnson KA. HIV-1 Reverse transcriptase resistance to nonnucleoside inhibitors Biochemistry. 35: 1054-1063. PMID 8547241 DOI: 10.1021/Bi952058+ |
0.425 |
|
| 1996 |
Spence RA, Johnson KA. Therapeutic potential of nonnucleoside reverse transcriptase inhibitors in the treatment of HIV infection Expert Opinion On Investigational Drugs. 5: 985-1001. DOI: 10.1517/13543784.5.8.985 |
0.301 |
|
| 1995 |
Gilbert SP, Webb MR, Brune M, Johnson KA. Pathway of processive ATP hydrolysis by kinesin Nature. 373: 671-676. PMID 7854446 DOI: 10.1038/373671A0 |
0.665 |
|
| 1995 |
Johnson KA. Rapid quench kinetic analysis of polymerases, adenosinetriphosphatases, and enzyme intermediates Methods in Enzymology. 249: 38-61. PMID 7791620 DOI: 10.1016/0076-6879(95)49030-2 |
0.442 |
|
| 1995 |
Johnson KA, Gilbert SP, Goldman Y, Riesler E, Hackney D, Howard J, Ferenczi M, Kuo S, Cooke R, Block S. Pathway of the microtubule-kinesin ATPase Biophysical Journal. 68: 173s-179s. PMID 7787062 |
0.321 |
|
| 1995 |
Correia JJ, Gilbert SP, Moyer ML, Johnson KA. Sedimentation studies on the kinesin motor domain constructs K401, K366, and K341. Biochemistry. 34: 4898-907. PMID 7718594 DOI: 10.1021/Bi00014A047 |
0.635 |
|
| 1995 |
Spence RA, Kati WM, Anderson KS, Johnson KA. Mechanism of inhibition of HIV-1 reverse transcriptase by nonnucleoside inhibitors Science. 267: 988-993. PMID 7532321 DOI: 10.1126/Science.7532321 |
0.39 |
|
| 1994 |
Gilbert SP, Johnson KA. Pre-steady-state kinetics of the microtubule·kinesin ATPase Biochemistry. 33: 1951-1960. PMID 8110800 DOI: 10.1021/Bi00173A044 |
0.648 |
|
| 1994 |
Kunkel TA, Patel SS, Johnson KA. Error-prone replication of repeated DNA sequences by T7 DNA polymerase in the absence of its processivity subunit Proceedings of the National Academy of Sciences of the United States of America. 91: 6830-6834. PMID 8041704 DOI: 10.1073/Pnas.91.15.6830 |
0.544 |
|
| 1994 |
Donlin MJ, Johnson KA. Mutants affecting nucleotide recognition by T7 DNA polymerase Biochemistry. 33: 14908-14917. PMID 7993917 DOI: 10.1021/Bi00253A030 |
0.396 |
|
| 1993 |
Gilbert SP, Johnson KA. Expression, purification, and characterization of the Drosophila kinesin motor domain produced in Escherichia coli Biochemistry. 32: 4677-4684. PMID 8485145 DOI: 10.1021/Bi00068A028 |
0.654 |
|
| 1993 |
Bevilacqua PC, Johnson KA, Turner DH. Cooperative and anticooperative binding to a ribozyme. Proceedings of the National Academy of Sciences of the United States of America. 90: 8357-61. PMID 8397404 DOI: 10.1073/Pnas.90.18.8357 |
0.372 |
|
| 1993 |
Harrison BC, Marchese-Ragona SP, Gilbert SP, Cheng N, Steven AC, Johnson KA. Decoration of the microtubule surface by one kinesin head per tubulin heterodimer Nature. 362: 73-75. PMID 8095324 DOI: 10.1038/362073A0 |
0.616 |
|
| 1993 |
Johnson KA. Conformational coupling in DNA polymerase fidelity Annual Review of Biochemistry. 62: 685-713. PMID 7688945 DOI: 10.1146/Annurev.Bi.62.070193.003345 |
0.404 |
|
| 1992 |
Bevilacqua PC, Kierzek R, Johnson KA, Turner DH. Dynamics of ribozyme binding of substrate revealed by fluorescence-detected stopped-flow methods. Science (New York, N.Y.). 258: 1355-8. PMID 1455230 DOI: 10.1126/Science.1455230 |
0.355 |
|
| 1992 |
Johnson KA. Conformational coupling in DNA polymerase information transfer Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 336: 107-112. PMID 1351289 DOI: 10.1098/Rstb.1992.0050 |
0.433 |
|
| 1992 |
Kati WM, Johnson KA, Jerva LF, Anderson KS. Mechanism and fidelity of HIV reverse transcriptase Journal of Biological Chemistry. 267: 25988-25997. PMID 1281479 |
0.338 |
|
| 1992 |
Johnson KA. 1 Transient-State Kinetic Analysis of Enzyme Reaction Pathways Enzymes. 20: 1-61. DOI: 10.1016/S1874-6047(08)60019-0 |
0.38 |
|
| 1991 |
Johnson KA. Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction Biochemistry. 30: 538-546. PMID 1988042 DOI: 10.1021/Bi00216A031 |
0.429 |
|
| 1991 |
Wong I, Patel SS, Johnson KA. An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics. Biochemistry. 30: 526-37. PMID 1846299 DOI: 10.1021/Bi00216A030 |
0.623 |
|
| 1991 |
Anderson KS, Kati WM, Ye QZ, Liu J, Walsh CT, Benesi AJ, Johnson KA. Isolation and structure elucidation of the 4-amino-4-deoxychorismate intermediate in the PABA enzymic pathway Journal of the American Chemical Society. 113: 3198-3200. DOI: 10.1021/Ja00008A073 |
0.421 |
|
| 1990 |
Shimizu T, Katsura T, Domanico PL, Marchese-Ragona SP, Johnson KA. Adenosine 5'-O-(3-thiotriphosphate) hydrolysis by dynein. Biochemistry. 28: 7022-7. PMID 2531007 DOI: 10.1021/Bi00443A036 |
0.394 |
|
| 1990 |
Shimizu T, Marchese-Ragona SP, Johnson KA. Activation of the dynein adenosinetriphosphatase by cross-linking to microtubules. Biochemistry. 28: 7016-21. PMID 2531006 DOI: 10.1021/Bi00443A035 |
0.365 |
|
| 1990 |
Anderson KS, Douglas Sammons R, Leo GC, Sikorski JA, Benesi AJ, Johnson KA. Observation by13C NMR of the EPSP synthase tetrahedral intermediate bound to the enzyme active site Biochemistry. 29: 1460-1465. PMID 2334707 DOI: 10.1021/Bi00458A017 |
0.343 |
|
| 1990 |
Shimizu T, Okuno M, Marchese-Ragona SP, Johnson KA. Phosphorothioate analogs of ATP as the substrates of dynein and ciliary or flagellar movement. European Journal of Biochemistry. 191: 543-50. PMID 2143985 DOI: 10.1111/J.1432-1033.1990.Tb19155.X |
0.356 |
|
| 1990 |
Johnson KA, Benkovic SJ. 4 Analysis of Protein Function by Mutagenesis Enzymes. 19: 159-211. DOI: 10.1016/S1874-6047(08)60197-3 |
0.327 |
|
| 1989 |
Anderson KS, Sikorski JA, Johnson KA. A tetrahedral intermediate in the EPSP synthase reaction observed by rapid quench kinetics. Biochemistry. 27: 7395-406. PMID 3061457 DOI: 10.1021/Bi00419A034 |
0.396 |
|
| 1989 |
Adams J, Johnson K, Matthews R, Benkovic SJ. Effects of distal point-site mutations on the binding and catalysis of dihydrofolate reductase from Escherichia coli. Biochemistry. 28: 6611-8. PMID 2675972 DOI: 10.1021/Bi00442A012 |
0.352 |
|
| 1989 |
Detrich HW, Johnson KA, Marchese-Ragona SP. Polymerization of Antarctic fish tubulins at low temperatures: energetic aspects. Biochemistry. 28: 10085-10093. PMID 2620064 DOI: 10.1021/Bi00452A031 |
0.315 |
|
| 1989 |
Holzbaur EL, Johnson KA. Microtubules accelerate ADP release by dynein. Biochemistry. 28: 7010-6. PMID 2531005 DOI: 10.1021/Bi00443A034 |
0.643 |
|
| 1989 |
Holzbaur EL, Johnson KA. ADP release is rate limiting in steady-state turnover by the dynein adenosinetriphosphatase. Biochemistry. 28: 5577-85. PMID 2528374 DOI: 10.1021/Bi00439A036 |
0.635 |
|
| 1989 |
Sulewski M, Marchese-Ragona SP, Johnson KA, Benkovic SJ. Mechanism of polynucleotide phosphorylase. Biochemistry. 28: 5855-64. PMID 2476178 DOI: 10.1021/Bi00440A023 |
0.316 |
|
| 1988 |
Anderson KS, Sikorski JA, Johnson KA. Evaluation of 5-enolpyruvoylshikimate-3-phosphate synthase substrate and inhibitor binding by stopped-flow and equilibrium fluorescence measurements. Biochemistry. 27: 1604-10. PMID 3284585 DOI: 10.1021/Bi00405A032 |
0.361 |
|
| 1987 |
Kuchta RD, Mizrahi V, Benkovic PA, Johnson KA, Benkovic SJ. Kinetic mechanism of DNA polymerase I (Klenow) Biochemistry. 26: 8410-8417. PMID 3327522 DOI: 10.1021/Bi00399A057 |
0.419 |
|
| 1987 |
Fierke CA, Johnson KA, Benkovic SJ. Construction and evaluation of the kinetic scheme associated with dihydrofolate reductase from Escherichia coli. Biochemistry. 26: 4085-92. PMID 3307916 DOI: 10.1021/Bi00387A052 |
0.351 |
|
| 1987 |
Taira K, Fierke CA, Chen J, Johnson KA, Benkovic SJ. On interpreting the inhibition of and catalysis by dihydrofolate reductase Trends in Biochemical Sciences. 12: 275-278. DOI: 10.1016/0968-0004(87)90134-4 |
0.358 |
|
| 1986 |
Johnson KA, Marchese-Ragona SP, Clutter DB, Holzbaur EL, Chilcote TJ. Dynein structure and function. Journal of Cell Science. Supplement. 5: 189-96. PMID 2958487 DOI: 10.1242/Jcs.1986.Supplement_5.12 |
0.596 |
|
| 1986 |
Johnson KA. [61] Rapid kinetic analysis of mechanochemical adenosinetriphosphatases Methods in Enzymology. 134: 677-705. PMID 2950300 DOI: 10.1016/0076-6879(86)34129-6 |
0.302 |
|
| 1986 |
Holzbaur EL, Johnson KA. Rate of ATP synthesis by dynein. Biochemistry. 25: 428-34. PMID 2937451 DOI: 10.1021/Bi00350A023 |
0.636 |
|
| 1986 |
Omoto CK, Johnson KA. Activation of the dynein adenosinetriphosphatase by microtubules Biochemistry. 25: 419-427. PMID 2937450 DOI: 10.1021/Bi00350A022 |
0.419 |
|
| 1985 |
Mizrahi V, Henrie RN, Marlier JF, Johnson KA, Benkovic SJ. Rate-limiting steps in the DNA polymerase I reaction pathway. Biochemistry. 24: 4010-8. PMID 3902078 DOI: 10.1021/Bi00336A031 |
0.388 |
|
| 1984 |
Johnson KA, Bryant FR, Benkovic SJ. Continuous assay for DNA polymerization by light scattering Analytical Biochemistry. 136: 192-194. PMID 6711807 DOI: 10.1016/0003-2697(84)90324-5 |
0.346 |
|
| 1983 |
Bryant FR, Johnson KA, Benkovic SJ. Elementary steps in the DNA polymerase I reaction pathway Biochemistry. 22: 3537-3546. PMID 6351905 DOI: 10.1021/Bi00284A001 |
0.443 |
|
| 1982 |
Johnson KA, Porter ME. Transient state kinetic analysis of the dynein ATPase Progress in Clinical and Biological Research. 80: 101-106. PMID 6212934 DOI: 10.1002/Cm.970020720 |
0.306 |
|
| 1982 |
Meek TD, Johnson KA, Villafranca JJ. Escherichia coli glutamine synthetase. Determination of rate-limiting steps by rapid-quench and isotope partitioning experiments. Biochemistry. 21: 2158-67. PMID 6124275 DOI: 10.1021/Bi00538A027 |
0.31 |
|
| 1982 |
Matherly LH, Johnson KA, Phillips AT. Transient-state kinetic analysis of urocanase Biochemistry. 21: 2795-2798. PMID 6124274 DOI: 10.1021/Bi00540A034 |
0.394 |
|
| 1979 |
Johnson KA, Borisy GG. Thermodynamic analysis of microtubule self-assembly in vitro. Journal of Molecular Biology. 133: 199-216. PMID 537051 DOI: 10.1016/0022-2836(79)90530-8 |
0.673 |
|
| 1978 |
Johnson KA, Taylor EW. Intermediate states of subfragment 1 and actosubfragment 1 ATPase: reevaluation of the mechanism. Biochemistry. 17: 3432-42. PMID 150856 DOI: 10.1021/Bi00610A002 |
0.686 |
|
| 1977 |
Murphy DB, Johnson KA, Borisy GG. Role of tubulin-associated proteins in microtubule nucleation and elongation. Journal of Molecular Biology. 117: 33-52. PMID 599568 DOI: 10.1016/0022-2836(77)90021-3 |
0.665 |
|
| 1977 |
Johnson KA, Borisy GG. Kinetic analysis of microtubule self-assembly in vitro. Journal of Molecular Biology. 117: 1-31. PMID 599563 DOI: 10.1016/0022-2836(77)90020-1 |
0.678 |
|
| 1975 |
Borisy GG, Marcum JM, Olmsted JB, Murphy DB, Johnson KA. Purification of tubulin and associated high molecular weight proteins from porcine brain and characterization of microtubule assembly in vitro. Annals of the New York Academy of Sciences. 253: 107-32. PMID 1056738 DOI: 10.1111/J.1749-6632.1975.Tb19196.X |
0.751 |
|
| 1975 |
Johnson KA, Borisy GG. The equilibrium assembly of microtubules in vitro. Society of General Physiologists Series. 30: 119-41. PMID 242078 |
0.603 |
|
| 1974 |
Olmsted JB, Marcum JM, Johnson KA, Allen C, Borisy GG. Microtuble assembly: some possible regulatory mechanisms. Journal of Supramolecular Structure. 2: 429-50. PMID 4612256 DOI: 10.1002/Jss.400020230 |
0.775 |
|
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