Scott Lowe - Publications

Affiliations: 
Stony Brook University, Stony Brook, NY, United States 
Area:
Molecular Biology, Cell Biology

166 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Bieging-Rolett KT, Kaiser AM, Morgens DW, Boutelle AM, Seoane JA, Van Nostrand EL, Zhu C, Houlihan SL, Mello SS, Yee BA, McClendon J, Pierce SE, Winters IP, Wang M, Connolly AJ, ... Lowe SW, et al. Zmat3 Is a Key Splicing Regulator in the p53 Tumor Suppression Program. Molecular Cell. 80: 452-469.e9. PMID 33157015 DOI: 10.1016/j.molcel.2020.10.022  0.4
2018 Moon SH, Huang CH, Houlihan SL, Regunath K, Freed-Pastor WA, Morris JP, Tschaharganeh DF, Kastenhuber ER, Barsotti AM, Culp-Hill R, Xue W, Ho YJ, Baslan T, Li X, Mayle A, ... ... Lowe SW, et al. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. PMID 30580964 DOI: 10.1016/j.cell.2018.11.011  0.32
2018 Faletti L, Peintner L, Neumann S, Sandler S, Grabinger T, Mac Nelly S, Merfort I, Huang CH, Tschaharganeh D, Kang TW, Heinzmann F, D'Artista L, Maurer U, Brunner T, Lowe S, et al. TNFα sensitizes hepatocytes to FasL-induced apoptosis by NFκB-mediated Fas upregulation. Cell Death & Disease. 9: 909. PMID 30185788 DOI: 10.1038/s41419-018-0935-9  0.32
2016 Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, ... ... Lowe SW, et al. p53-Dependent Nestin Regulation Links Tumor Suppression to Cellular Plasticity in Liver Cancer. Cell. 165: 1546-1547. PMID 27259155 DOI: 10.1016/j.cell.2016.05.058  0.32
2016 Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK. SCRIBBLE is required for pregnancy-induced alveologenesis in the adult mammary gland. Journal of Cell Science. PMID 27179074 DOI: 10.1242/jcs.185413  0.44
2016 Liu Y, Chen C, Xu Z, Scuoppo C, Rillahan CD, Gao J, Spitzer B, Bosbach B, Kastenhuber ER, Baslan T, Ackermann S, Cheng L, Wang Q, Niu T, Schultz N, ... ... Lowe SW, et al. Deletions linked to TP53 loss drive cancer through p53-independent mechanisms. Nature. PMID 26982726 DOI: 10.1038/nature17157  0.44
2016 Ebbesen SH, Scaltriti M, Bialucha CU, Morse N, Kastenhuber ER, Wen HY, Dow LE, Baselga J, Lowe SW. Pten loss promotes MAPK pathway dependency in HER2/neu breast carcinomas. Proceedings of the National Academy of Sciences of the United States of America. PMID 26929372 DOI: 10.1073/pnas.1523693113  0.44
2015 Cheloufi S, Elling U, Hopfgartner B, Jung YL, Murn J, Ninova M, Hubmann M, Badeaux AI, Euong Ang C, Tenen D, Wesche DJ, Abazova N, Hogue M, Tasdemir N, Brumbaugh J, ... ... Lowe SW, et al. The histone chaperone CAF-1 safeguards somatic cell identity. Nature. 528: 218-224. PMID 26659182 DOI: 10.1038/nature15749  0.44
2015 Dow LE, O'Rourke KP, Simon J, Tschaharganeh DF, van Es JH, Clevers H, Lowe SW. Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer. Cell. 161: 1539-52. PMID 26091037 DOI: 10.1016/j.cell.2015.05.033  0.44
2015 Brondfield S, Umesh S, Corella A, Zuber J, Rappaport AR, Gaillard C, Lowe SW, Goga A, Kogan SC. Direct and indirect targeting of MYC to treat acute myeloid leukemia. Cancer Chemotherapy and Pharmacology. 76: 35-46. PMID 25956709 DOI: 10.1007/s00280-015-2766-z  0.44
2015 Zhao Z, Chen CC, Rillahan CD, Shen R, Kitzing T, McNerney ME, Diaz-Flores E, Zuber J, Shannon K, Le Beau MM, Spector MS, Kogan SC, Lowe SW. Cooperative loss of RAS feedback regulation drives myeloid leukemogenesis. Nature Genetics. 47: 539-43. PMID 25822087 DOI: 10.1038/ng.3251  0.44
2015 Li J, Chanrion M, Sawey E, Wang T, Chow E, Tward A, Su Y, Xue W, Lucito R, Zender L, Lowe SW, Bishop JM, Powers S. Reciprocal interaction of Wnt and RXR-α pathways in hepatocyte development and hepatocellular carcinoma. Plos One. 10: e0118480. PMID 25738607 DOI: 10.1371/journal.pone.0118480  0.44
2015 Dow LE, Fisher J, O'Rourke KP, Muley A, Kastenhuber ER, Livshits G, Tschaharganeh DF, Socci ND, Lowe SW. Inducible in vivo genome editing with CRISPR-Cas9. Nature Biotechnology. 33: 390-4. PMID 25690852 DOI: 10.1038/nbt.3155  0.44
2015 Vidal SJ, Rodriguez-Bravo V, Quinn SA, Rodriguez-Barrueco R, Lujambio A, Williams E, Sun X, de la Iglesia-Vicente J, Lee A, Readhead B, Chen X, Galsky M, Esteve B, Petrylak DP, Dudley JT, ... ... Lowe SW, et al. A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer. Cancer Cell. 27: 223-39. PMID 25670080 DOI: 10.1016/j.ccell.2014.11.013  0.44
2015 Appelmann I, Rillahan CD, de Stanchina E, Carbonetti G, Chen C, Lowe SW, Sherr CJ. Janus kinase inhibition by ruxolitinib extends dasatinib- and dexamethasone-induced remissions in a mouse model of Ph+ ALL. Blood. 125: 1444-51. PMID 25499760 DOI: 10.1182/blood-2014-09-601062  0.44
2014 Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q. Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood. 124: 3947-55. PMID 25361812 DOI: 10.1182/blood-2014-05-574582  0.44
2014 Rudalska R, Dauch D, Longerich T, McJunkin K, Wuestefeld T, Kang TW, Hohmeyer A, Pesic M, Leibold J, von Thun A, Schirmacher P, Zuber J, Weiss KH, Powers S, Malek NP, ... ... Lowe SW, et al. In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer. Nature Medicine. 20: 1138-46. PMID 25216638 DOI: 10.1038/nm.3679  0.44
2014 Huang CH, Lujambio A, Zuber J, Tschaharganeh DF, Doran MG, Evans MJ, Kitzing T, Zhu N, de Stanchina E, Sawyers CL, Armstrong SA, Lewis JS, Sherr CJ, Lowe SW. CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma. Genes & Development. 28: 1800-14. PMID 25128497 DOI: 10.1101/gad.244368.114  0.44
2014 Yuan TL, Fellmann C, Lee CS, Ritchie CD, Thapar V, Lee LC, Hsu DJ, Grace D, Carver JO, Zuber J, Luo J, McCormick F, Lowe SW. Development of siRNA payloads to target KRAS-mutant cancer. Cancer Discovery. 4: 1182-97. PMID 25100204 DOI: 10.1158/2159-8290.CD-13-0900  0.44
2014 Tschaharganeh DF, Xue W, Calvisi DF, Evert M, Michurina TV, Dow LE, Banito A, Katz SF, Kastenhuber ER, Weissmueller S, Huang CH, Lechel A, Andersen JB, Capper D, Zender L, ... ... Lowe SW, et al. p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer. Cell. 158: 579-92. PMID 25083869 DOI: 10.1016/j.cell.2014.05.051  0.44
2014 Zaiss AK, Zuber J, Chu C, Machado HB, Jiao J, Catapang AB, Ishikawa TO, Gil JS, Lowe SW, Herschman HR. Reversible suppression of cyclooxygenase 2 (COX-2) expression in vivo by inducible RNA interference. Plos One. 9: e101263. PMID 24988319 DOI: 10.1371/journal.pone.0101263  0.44
2014 Mazurek A, Park Y, Miething C, Wilkinson JE, Gillis J, Lowe SW, Vakoc CR, Stillman B. Acquired dependence of acute myeloid leukemia on the DEAD-box RNA helicase DDX5. Cell Reports. 7: 1887-99. PMID 24910429 DOI: 10.1016/j.celrep.2014.05.019  0.44
2014 Chen C, Liu Y, Rappaport AR, Kitzing T, Schultz N, Zhao Z, Shroff AS, Dickins RA, Vakoc CR, Bradner JE, Stock W, LeBeau MM, Shannon KM, Kogan S, Zuber J, ... Lowe SW, et al. MLL3 is a haploinsufficient 7q tumor suppressor in acute myeloid leukemia Cancer Cell. 25: 652-665. PMID 24794707 DOI: 10.1016/j.ccr.2014.03.016  0.44
2014 Lito P, Saborowski A, Yue J, Solomon M, Joseph E, Gadal S, Saborowski M, Kastenhuber E, Fellmann C, Ohara K, Morikami K, Miura T, Lukacs C, Ishii N, Lowe S, et al. Disruption of CRAF-mediated MEK activation is required for effective MEK inhibition in KRAS mutant tumors. Cancer Cell. 25: 697-710. PMID 24746704 DOI: 10.1016/j.ccr.2014.03.011  0.44
2014 Weissmueller S, Manchado E, Saborowski M, Morris JP, Wagenblast E, Davis CA, Moon SH, Pfister NT, Tschaharganeh DF, Kitzing T, Aust D, Markert EK, Wu J, Grimmond SM, Pilarsky C, ... ... Lowe SW, et al. Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling. Cell. 157: 382-94. PMID 24725405 DOI: 10.1016/j.cell.2014.01.066  0.44
2014 Bots M, Verbrugge I, Martin BP, Salmon JM, Ghisi M, Baker A, Stanley K, Shortt J, Ossenkoppele GJ, Zuber J, Rappaport AR, Atadja P, Lowe SW, Johnstone RW. Differentiation therapy for the treatment of t(8;21) acute myeloid leukemia using histone deacetylase inhibitors. Blood. 123: 1341-52. PMID 24415537 DOI: 10.1182/blood-2013-03-488114  0.44
2013 Nasr Z, Dow LE, Paquet M, Chu J, Ravindar K, Somaiah R, Deslongchamps P, Porco JA, Lowe SW, Pelletier J. Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia. Bmc Pharmacology & Toxicology. 14: 58. PMID 24219888 DOI: 10.1186/2050-6511-14-58  0.44
2013 Davare MA, Saborowski A, Eide CA, Tognon C, Smith RL, Elferich J, Agarwal A, Tyner JW, Shinde UP, Lowe SW, Druker BJ. Foretinib is a potent inhibitor of oncogenic ROS1 fusion proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: 19519-24. PMID 24218589 DOI: 10.1073/pnas.1319583110  0.44
2013 Saborowski A, Saborowski M, Davare MA, Druker BJ, Klimstra DS, Lowe SW. Mouse model of intrahepatic cholangiocarcinoma validates FIG-ROS as a potent fusion oncogene and therapeutic target. Proceedings of the National Academy of Sciences of the United States of America. 110: 19513-8. PMID 24154728 DOI: 10.1073/pnas.1311707110  0.44
2013 Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, ... ... Lowe SW, et al. Induction of sarcomas by mutant IDH2. Genes & Development. 27: 1986-98. PMID 24065766 DOI: 10.1101/gad.226753.113  0.44
2013 Chen C, Liu Y, Lu C, Cross JR, Morris JP, Shroff AS, Ward PS, Bradner JE, Thompson C, Lowe SW. Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition. Genes & Development. 27: 1974-85. PMID 24065765 DOI: 10.1101/gad.226613.113  0.44
2013 Iannello A, Thompson TW, Ardolino M, Lowe SW, Raulet DH. p53-dependent chemokine production by senescent tumor cells supports NKG2D-dependent tumor elimination by natural killer cells. The Journal of Experimental Medicine. 210: 2057-69. PMID 24043758 DOI: 10.1084/jem.20130783  0.44
2013 Shah S, Schrader KA, Waanders E, Timms AE, Vijai J, Miething C, Wechsler J, Yang J, Hayes J, Klein RJ, Zhang J, Wei L, Wu G, Rusch M, Nagahawatte P, ... ... Lowe SW, et al. A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia. Nature Genetics. 45: 1226-31. PMID 24013638 DOI: 10.1038/ng.2754  0.44
2013 Premsrirut PK, Dow LE, Park Y, Hannon GJ, Lowe SW. Creating transgenic shRNA mice by recombinase-mediated cassette exchange Cold Spring Harbor Protocols. 2013: 835-842. PMID 24003198 DOI: 10.1101/pdb.prot077057  0.44
2013 Rajaram M, Zhang J, Wang T, Li J, Kuscu C, Qi H, Kato M, Grubor V, Weil RJ, Helland A, Borrenson-Dale AL, Cho KR, Levine DA, Houghton AN, Wolchok JD, ... ... Lowe SW, et al. Two Distinct Categories of Focal Deletions in Cancer Genomes. Plos One. 8: e66264. PMID 23805207 DOI: 10.1371/journal.pone.0066264  0.44
2013 Lujambio A, Akkari L, Simon J, Grace D, Tschaharganeh DF, Bolden JE, Zhao Z, Thapar V, Joyce JA, Krizhanovsky V, Lowe SW. Non-cell-autonomous tumor suppression by p53. Cell. 153: 449-60. PMID 23562644 DOI: 10.1016/j.cell.2013.03.020  0.44
2013 Mills JR, Malina A, Lee T, Di Paola D, Larsson O, Miething C, Grosse F, Tang H, Zannis-Hadjopoulos M, Lowe SW, Pelletier J. RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model. Blood. 121: 3402-12. PMID 23440244 DOI: 10.1182/blood-2012-06-434365  0.44
2013 Takiguchi M, Dow LE, Prier JE, Carmichael CL, Kile BT, Turner SJ, Lowe SW, Huang DC, Dickins RA. Variability of inducible expression across the hematopoietic system of tetracycline transactivator transgenic mice. Plos One. 8: e54009. PMID 23326559 DOI: 10.1371/journal.pone.0054009  0.44
2013 Wall M, Poortinga G, Stanley KL, Lindemann RK, Bots M, Chan CJ, Bywater MJ, Kinross KM, Astle MV, Waldeck K, Hannan KM, Shortt J, Smyth MJ, Lowe SW, Hannan RD, et al. The mTORC1 inhibitor everolimus prevents and treats Eμ-Myc lymphoma by restoring oncogene-induced senescence. Cancer Discovery. 3: 82-95. PMID 23242809 DOI: 10.1158/2159-8290.CD-12-0404  0.44
2013 Shi J, Wang E, Zuber J, Rappaport A, Taylor M, Johns C, Lowe SW, Vakoc CR. The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras G12D acute myeloid leukemia Oncogene. 32: 930-938. PMID 22469984 DOI: 10.1038/onc.2012.110  0.44
2012 Ito K, Smith BR, Parashurama N, Yoon JK, Song SY, Miething C, Mallick P, Lowe S, Gambhir SS. Unexpected dissemination patterns in lymphoma progression revealed by serial imaging within a murine lymph node. Cancer Research. 72: 6111-8. PMID 23033441 DOI: 10.1158/0008-5472.CAN-12-2579  0.44
2012 Tucci P, Agostini M, Grespi F, Markert EK, Terrinoni A, Vousden KH, Muller PA, Dötsch V, Kehrloesser S, Sayan BS, Giaccone G, Lowe SW, Takahashi N, Vandenabeele P, Knight RA, et al. Loss of p63 and its microRNA-205 target results in enhanced cell migration and metastasis in prostate cancer. Proceedings of the National Academy of Sciences of the United States of America. 109: 15312-7. PMID 22949650 DOI: 10.1073/pnas.1110977109  0.44
2012 Mattarollo SR, West AC, Steegh K, Duret H, Paget C, Martin B, Matthews GM, Shortt J, Chesi M, Bergsagel PL, Bots M, Zuber J, Lowe SW, Johnstone RW, Smyth MJ. NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma. Blood. 120: 3019-29. PMID 22932803 DOI: 10.1182/blood-2012-04-426643  0.44
2012 Aksoy O, Chicas A, Zeng T, Zhao Z, McCurrach M, Wang X, Lowe SW. The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence. Genes & Development. 26: 1546-57. PMID 22802529 DOI: 10.1101/gad.196238.112  0.44
2012 Chandra T, Kirschner K, Thuret JY, Pope BD, Ryba T, Newman S, Ahmed K, Samarajiwa SA, Salama R, Carroll T, Stark R, Janky R, Narita M, Xue L, Chicas A, ... ... Lowe SW, et al. Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Molecular Cell. 47: 203-14. PMID 22795131 DOI: 10.1016/j.molcel.2012.06.010  0.44
2012 Bywater MJ, Poortinga G, Sanij E, Hein N, Peck A, Cullinane C, Wall M, Cluse L, Drygin D, Anderes K, Huser N, Proffitt C, Bliesath J, Haddach M, Schwaebe MK, ... ... Lowe SW, et al. Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53. Cancer Cell. 22: 51-65. PMID 22789538 DOI: 10.1016/j.ccr.2012.05.019  0.44
2012 Scuoppo C, Miething C, Lindqvist L, Reyes J, Ruse C, Appelmann I, Yoon S, Krasnitz A, Teruya-Feldstein J, Pappin D, Pelletier J, Lowe SW. A tumour suppressor network relying on the polyamine-hypusine axis. Nature. 487: 244-8. PMID 22722845 DOI: 10.1038/nature11126  0.44
2012 Wolyniec K, Shortt J, de Stanchina E, Levav-Cohen Y, Alsheich-Bartok O, Louria-Hayon I, Corneille V, Kumar B, Woods SJ, Opat S, Johnstone RW, Scott CL, Segal D, Pandolfi PP, Fox S, ... ... Lowe SW, et al. E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis. Blood. 120: 822-32. PMID 22689861 DOI: 10.1182/blood-2011-10-387647  0.44
2012 Chicas A, Kapoor A, Wang X, Aksoy O, Evertts AG, Zhang MQ, Garcia BA, Bernstein E, Lowe SW. H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence. Proceedings of the National Academy of Sciences of the United States of America. 109: 8971-6. PMID 22615382 DOI: 10.1073/pnas.1119836109  0.44
2012 Xue W, Kitzing T, Roessler S, Zuber J, Krasnitz A, Schultz N, Revill K, Weissmueller S, Rappaport AR, Simon J, Zhang J, Luo W, Hicks J, Zender L, Wang XW, ... ... Lowe SW, et al. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proceedings of the National Academy of Sciences of the United States of America. 109: 8212-7. PMID 22566646 DOI: 10.1073/pnas.1206062109  0.44
2012 Bergerson RJ, Collier LS, Sarver AL, Been RA, Lugthart S, Diers MD, Zuber J, Rappaport AR, Nixon MJ, Silverstein KA, Fan D, Lamblin AF, Wolff L, Kersey JH, Delwel R, ... Lowe SW, et al. An insertional mutagenesis screen identifies genes that cooperate with Mll-AF9 in a murine leukemogenesis model. Blood. 119: 4512-23. PMID 22427200 DOI: 10.1182/blood-2010-04-281428  0.44
2012 Bazarov AV, Lee WJ, Bazarov I, Bosire M, Hines WC, Stankovich B, Chicas A, Lowe SW, Yaswen P. The specific role of pRb in p16 (INK4A) -mediated arrest of normal and malignant human breast cells. Cell Cycle (Georgetown, Tex.). 11: 1008-13. PMID 22333593 DOI: 10.4161/cc.11.5.19492  0.44
2012 Dow LE, Premsrirut PK, Zuber J, Fellmann C, McJunkin K, Miething C, Park Y, Dickins RA, Hannon GJ, Lowe SW. A pipeline for the generation of shRNA transgenic mice Nature Protocols. 7: 374-393. PMID 22301776 DOI: 10.1038/nprot.2011.446  0.44
2012 Glaser SP, Lee EF, Trounson E, Bouillet P, Wei A, Fairlie WD, Izon DJ, Zuber J, Rappaport AR, Herold MJ, Alexander WS, Lowe SW, Robb L, Strasser A. Anti-apoptotic Mcl-1 is essential for the development and sustained growth of acute myeloid leukemia. Genes & Development. 26: 120-5. PMID 22279045 DOI: 10.1101/gad.182980.111  0.44
2012 Freed-Pastor WA, Mizuno H, Zhao X, Langerød A, Moon SH, Rodriguez-Barrueco R, Barsotti A, Chicas A, Li W, Polotskaia A, Bissell MJ, Osborne TF, Tian B, Lowe SW, Silva JM, et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell. 148: 244-58. PMID 22265415 DOI: 10.1016/j.cell.2011.12.017  0.44
2012 Tan X, Lu ZJ, Gao G, Xu Q, Hu L, Fellmann C, Li MZ, Qu H, Lowe SW, Hannon GJ, Elledge SJ. Tiling genomes of pathogenic viruses identifies potent antiviral shRNAs and reveals a role for secondary structure in shRNA efficacy Proceedings of the National Academy of Sciences of the United States of America. 109: 869-874. PMID 22219365 DOI: 10.1073/pnas.1119873109  0.44
2012 Spector MS, Iossifov I, Kritharis A, He C, Kolitz JE, Lowe SW, Allen SL. Mast-cell leukemia exome sequencing reveals a mutation in the IgE mast-cell receptor β chain and KIT V654A Leukemia. 26: 1422-1425. PMID 22173243 DOI: 10.1038/leu.2011.354  0.44
2011 Chien Y, Scuoppo C, Wang X, Fang X, Balgley B, Bolden JE, Premsrirut P, Luo W, Chicas A, Lee CS, Kogan SC, Lowe SW. Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity. Genes & Development. 25: 2125-36. PMID 21979375 DOI: 10.1101/gad.17276711  0.44
2011 Fairfield H, Gilbert GJ, Barter M, Corrigan RR, Curtain M, Ding Y, D'Ascenzo M, Gerhardt DJ, He C, Huang W, Richmond T, Rowe L, Probst FJ, Bergstrom DE, Murray SA, ... ... Lowe SW, et al. Mutation discovery in mice by whole exome sequencing. Genome Biology. 12: R86. PMID 21917142 DOI: 10.1186/gb-2011-12-9-r86  0.44
2011 Zuber J, Rappaport AR, Luo W, Wang E, Chen C, Vaseva AV, Shi J, Weissmueller S, Fellmann C, Fellman C, Taylor MJ, Weissenboeck M, Graeber TG, Kogan SC, Vakoc CR, ... Lowe SW, et al. An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance. Genes & Development. 25: 1628-40. PMID 21828272 DOI: 10.1101/gad.17269211  0.44
2011 Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, ... ... Lowe SW, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 478: 524-8. PMID 21814200 DOI: 10.1038/nature10334  0.44
2011 Gutmann DH, Stiles CD, Lowe SW, Bollag GE, Furnari FB, Charest AL. Report from the fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop. Neuro-Oncology. 13: 692-9. PMID 21727208 DOI: 10.1093/neuonc/nor080  0.44
2011 McJunkin K, Mazurek A, Premsrirut PK, Zuber J, Dow LE, Simon J, Stillman B, Lowe SW. Reversible suppression of an essential gene in adult mice using transgenic RNA interference. Proceedings of the National Academy of Sciences of the United States of America. 108: 7113-8. PMID 21482754 DOI: 10.1073/pnas.1104097108  0.44
2011 Premsrirut PK, Dow LE, Kim SY, Camiolo M, Malone CD, Miething C, Scuoppo C, Zuber J, Dickins RA, Kogan SC, Shroyer KR, Sordella R, Hannon GJ, Lowe SW. A rapid and scalable system for studying gene function in mice using conditional RNA interference Cell. 145: 145-158. PMID 21458673 DOI: 10.1016/j.cell.2011.03.012  0.44
2011 Sawey ET, Chanrion M, Cai C, Wu G, Zhang J, Zender L, Zhao A, Busuttil RW, Yee H, Stein L, French DM, Finn RS, Lowe SW, Powers S. Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening. Cancer Cell. 19: 347-58. PMID 21397858 DOI: 10.1016/j.ccr.2011.01.040  0.32
2011 Karni-Schmidt O, Castillo-Martin M, Shen TH, HuaiShen T, Gladoun N, Domingo-Domenech J, Sanchez-Carbayo M, Li Y, Lowe S, Prives C, Cordon-Cardo C. Distinct expression profiles of p63 variants during urothelial development and bladder cancer progression. The American Journal of Pathology. 178: 1350-60. PMID 21356385 DOI: 10.1016/j.ajpath.2010.11.061  0.44
2011 Fellmann C, Zuber J, McJunkin K, Chang K, Malone CD, Dickins RA, Xu Q, Hengartner MO, Elledge SJ, Hannon GJ, Lowe SW. Functional identification of optimized RNAi triggers using a massively parallel sensor assay. Molecular Cell. 41: 733-46. PMID 21353615 DOI: 10.1016/j.molcel.2011.02.008  0.44
2011 Pardee TS, Zuber J, Lowe SW. Flt3-ITD alters chemotherapy response in vitro and in vivo in a p53-dependent manner Experimental Hematology. 39: 473-485. PMID 21288478 DOI: 10.1016/j.exphem.2011.01.009  0.44
2011 Zuber J, McJunkin K, Fellmann C, Dow LE, Taylor MJ, Hannon GJ, Lowe SW. Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi Nature Biotechnology. 29: 79-85. PMID 21131983 DOI: 10.1038/nbt.1720  0.44
2011 Xu MZ, Chan SW, Liu AM, Wong KF, Fan ST, Chen J, Poon RT, Zender L, Lowe SW, Hong W, Luk JM. AXL receptor kinase is a mediator of YAP-dependent oncogenic functions in hepatocellular carcinoma. Oncogene. 30: 1229-40. PMID 21076472 DOI: 10.1038/onc.2010.504  0.32
2010 Takiguchi M, James C, Josefsson EC, Carmichael CL, Premsrirut PK, Lowe SW, Hamilton JR, Huang DC, Kile BT, Dickins RA. Transgenic, inducible RNAi in megakaryocytes and platelets in mice. Journal of Thrombosis and Haemostasis : Jth. 8: 2751-6. PMID 21138522 DOI: 10.1111/j.1538-7836.2010.04077.x  0.44
2010 Jones L, Wei G, Sevcikova S, Phan V, Jain S, Shieh A, Wong JC, Li M, Dubansky J, Maunakea ML, Ochoa R, Zhu G, Tennant TR, Shannon KM, Lowe SW, et al. Gain of MYC underlies recurrent trisomy of the MYC chromosome in acute promyelocytic leukemia. The Journal of Experimental Medicine. 207: 2581-94. PMID 21059853 DOI: 10.1084/jem.20091071  0.44
2010 Schreiber SL, Shamji AF, Clemons PA, Hon C, Koehler AN, Munoz B, Palmer M, Stern AM, Wagner BK, Powers S, Lowe SW, Guo X, Krasnitz A, Sawey ET, et al. Towards patient-based cancer therapeutics. Nature Biotechnology. 28: 904-6. PMID 20829823 DOI: 10.1038/nbt0910-904  0.44
2010 Ko FC, Chan LK, Tung EK, Lowe SW, Ng IO, Yam JW. Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis. Gastroenterology. 139: 1397-407. PMID 20600027 DOI: 10.1053/j.gastro.2010.06.051  0.44
2010 Zhao Z, Zuber J, Diaz-Flores E, Lintault L, Kogan SC, Shannon K, Lowe SW. p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal. Genes & Development. 24: 1389-402. PMID 20595231 DOI: 10.1101/gad.1940710  0.44
2010 Bazarov AV, Van Sluis M, Hines WC, Bassett E, Beliveau A, Campeau E, Mukhopadhyay R, Lee WJ, Melodyev S, Zaslavsky Y, Lee L, Rodier F, Chicas A, Lowe SW, Benhattar J, et al. p16(INK4a) -mediated suppression of telomerase in normal and malignant human breast cells. Aging Cell. 9: 736-46. PMID 20569236 DOI: 10.1111/j.1474-9726.2010.00599.x  0.44
2010 Sendoel A, Kohler I, Fellmann C, Lowe SW, Hengartner MO. HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase. Nature. 465: 577-83. PMID 20520707 DOI: 10.1038/nature09141  0.44
2010 Chicas A, Wang X, Zhang C, McCurrach M, Zhao Z, Mert O, Dickins RA, Narita M, Zhang M, Lowe SW. Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence. Cancer Cell. 17: 376-87. PMID 20385362 DOI: 10.1016/j.ccr.2010.01.023  0.44
2010 Pineau P, Volinia S, McJunkin K, Marchio A, Battiston C, Terris B, Mazzaferro V, Lowe SW, Croce CM, Dejean A. miR-221 overexpression contributes to liver tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 107: 264-9. PMID 20018759 DOI: 10.1073/pnas.0907904107  0.44
2009 Olive V, Bennett MJ, Walker JC, Ma C, Jiang I, Cordon-Cardo C, Li QJ, Lowe SW, Hannon GJ, He L. miR-19 is a key oncogenic component of mir-17-92. Genes & Development. 23: 2839-49. PMID 20008935 DOI: 10.1101/gad.1861409  0.44
2009 Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, McCombie RW, Hemann MT, Hannon GJ, Powers S, Lowe SW. Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell. 16: 324-35. PMID 19800577 DOI: 10.1016/j.ccr.2009.08.015  0.44
2009 Krizhanovsky V, Lowe SW. Stem cells: The promises and perils of p53. Nature. 460: 1085-6. PMID 19713919 DOI: 10.1038/4601085a  0.32
2009 Liu LX, Lee NP, Chan VW, Xue W, Zender L, Zhang C, Mao M, Dai H, Wang XL, Xu MZ, Lee TK, Ng IO, Chen Y, Kung HF, Lowe SW, et al. Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma. Hepatology (Baltimore, Md.). 50: 1453-63. PMID 19676131 DOI: 10.1002/hep.23143  0.32
2009 Xu MZ, Yao TJ, Lee NP, Ng IO, Chan YT, Zender L, Lowe SW, Poon RT, Luk JM. Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma. Cancer. 115: 4576-85. PMID 19551889 DOI: 10.1002/cncr.24495  0.32
2009 Zuber J, Radtke I, Pardee TS, Zhao Z, Rappaport AR, Luo W, McCurrach ME, Yang MM, Dolan ME, Kogan SC, Downing JR, Lowe SW. Mouse models of human AML accurately predict chemotherapy response. Genes & Development. 23: 877-89. PMID 19339691 DOI: 10.1101/gad.1771409  0.44
2009 Ma O, Cai WW, Zender L, Dayaram T, Shen J, Herron AJ, Lowe SW, Man TK, Lau CC, Donehower LA. MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression. Cancer Research. 69: 2559-67. PMID 19276372 DOI: 10.1158/0008-5472.CAN-08-2929  0.32
2009 Laska MJ, Lowe SW, Zender L, Hearn S, Vogel U, Jensen UB, Bric A, Nexø BA. Enforced expression of PPP1R13L increases tumorigenesis and invasion through p53-dependent and p53-independent mechanisms. Molecular Carcinogenesis. 48: 832-42. PMID 19263435 DOI: 10.1002/mc.20528  0.44
2009 Keng VW, Villanueva A, Chiang DY, Dupuy AJ, Ryan BJ, Matise I, Silverstein KA, Sarver A, Starr TK, Akagi K, Tessarollo L, Collier LS, Powers S, Lowe SW, Jenkins NA, et al. A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nature Biotechnology. 27: 264-74. PMID 19234449 DOI: 10.1038/nbt.1526  0.44
2008 Krizhanovsky V, Xue W, Zender L, Yon M, Hernando E, Lowe SW. Implications of cellular senescence in tissue damage response, tumor suppression, and stem cell biology. Cold Spring Harbor Symposia On Quantitative Biology. 73: 513-22. PMID 19150958 DOI: 10.1101/sqb.2008.73.048  0.32
2008 Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, Ma B, Zender P, Kubicka S, Luk JM, Schirmacher P, McCombie WR, Wigler M, Hicks J, Hannon GJ, Powers S, ... Lowe SW, et al. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell. 135: 852-64. PMID 19012953 DOI: 10.1016/j.cell.2008.09.061  0.44
2008 Gyrd-Hansen M, Darding M, Miasari M, Santoro MM, Zender L, Xue W, Tenev T, da Fonseca PCA, Zvelebil M, Bujnicki JM, Lowe S, Silke J, Meier P. IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis Nature Cell Biology. 10: 1309-1317. PMID 18931663 DOI: 10.1038/ncb1789  0.44
2008 Karni R, Hippo Y, Lowe SW, Krainer AR. The splicing-factor oncoprotein SF2/ASF activates mTORC1. Proceedings of the National Academy of Sciences of the United States of America. 105: 15323-7. PMID 18832178 DOI: 10.1073/pnas.0801376105  0.44
2008 Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW. Senescence of activated stellate cells limits liver fibrosis. Cell. 134: 657-67. PMID 18724938 DOI: 10.1016/j.cell.2008.06.049  0.44
2008 Mavrakis KJ, Zhu H, Silva RL, Mills JR, Teruya-Feldstein J, Lowe SW, Tam W, Pelletier J, Wendel HG. Tumorigenic activity and therapeutic inhibition of Rheb GTPase. Genes & Development. 22: 2178-88. PMID 18708578 DOI: 10.1101/gad.1690808  0.44
2008 Mills JR, Hippo Y, Robert F, Chen SM, Malina A, Lin CJ, Trojahn U, Wendel HG, Charest A, Bronson RT, Kogan SC, Nadon R, Housman DE, Lowe SW, Pelletier J. mTORC1 promotes survival through translational control of Mcl-1. Proceedings of the National Academy of Sciences of the United States of America. 105: 10853-8. PMID 18664580 DOI: 10.1073/pnas.0804821105  0.44
2008 Burgess DJ, Doles J, Zender L, Xue W, Ma B, McCombie WR, Hannon GJ, Lowe SW, Hemann MT. Topoisomerase levels determine chemotherapy response in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 9053-8. PMID 18574145 DOI: 10.1073/pnas.0803513105  0.44
2008 Xue W, Krasnitz A, Lucito R, Sordella R, Vanaelst L, Cordon-Cardo C, Singer S, Kuehnel F, Wigler M, Powers S, Zender L, Lowe SW. DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development. 22: 1439-44. PMID 18519636 DOI: 10.1101/gad.1672608  0.44
2008 Tworkowski KA, Chakraborty AA, Samuelson AV, Seger YR, Narita M, Hannon GJ, Lowe SW, Tansey WP. Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc Proceedings of the National Academy of Sciences of the United States of America. 105: 6103-6108. PMID 18413597 DOI: 10.1073/pnas.0802095105  0.44
2008 Chien Y, Lowe SW. Secreting Tumor Suppression Cell. 132: 339-341. PMID 18267066 DOI: 10.1016/j.cell.2008.01.022  0.44
2007 Wendel HG, Silva RL, Malina A, Mills JR, Zhu H, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Teruya-Feldstein J, Pelletier J, Lowe SW. Dissecting eIF4E action in tumorigenesis. Genes & Development. 21: 3232-7. PMID 18055695 DOI: 10.1101/gad.1604407  0.44
2007 He L, He X, Lowe SW, Hannon GJ. microRNAs join the p53 network - Another piece in the tumour-suppression puzzle Nature Reviews Cancer. 7: 819-822. PMID 17914404 DOI: 10.1038/nrc2232  0.44
2007 Ha L, Ichikawa T, Anver M, Dickins R, Lowe S, Sharpless NE, Krimpenfort P, Depinho RA, Bennett DC, Sviderskaya EV, Merlino G. ARF functions as a melanoma tumor suppressor by inducing p53-independent senescence. Proceedings of the National Academy of Sciences of the United States of America. 104: 10968-73. PMID 17576930 DOI: 10.1073/pnas.0611638104  0.44
2007 Dickins RA, McJunkin K, Hernando E, Premsrirut PK, Krizhanovsky V, Burgess DJ, Kim SY, Cordon-Cardo C, Zender L, Hannon GJ, Lowe SW. Tissue-specific and reversible RNA interference in transgenic mice. Nature Genetics. 39: 914-21. PMID 17572676 DOI: 10.1038/ng2045  0.44
2007 He L, He X, Lim LP, De Stanchina E, Xuan Z, Liang Y, Xue W, Zender L, Magnus J, Ridzon D, Jackson AL, Linsley PS, Chen C, Lowe SW, Cleary MA, et al. A microRNA component of the p53 tumour suppressor network Nature. 447: 1130-1134. PMID 17554337 DOI: 10.1038/nature05939  0.44
2007 Flinterman MB, Mymryk JS, Klanrit P, Yousef AF, Lowe SW, Caldas C, Gäken J, Farzaneh F, Tavassoli M. p400 function is required for the adenovirus E1A-mediated suppression of EGFR and tumour cell killing. Oncogene. 26: 6863-74. PMID 17486071 DOI: 10.1038/sj.onc.1210497  0.44
2007 Lindemann RK, Newbold A, Whitecross KF, Cluse LA, Frew AJ, Ellis L, Williams S, Wiegmans AP, Dear AE, Scott CL, Pellegrini M, Wei A, Richon VM, Marks PA, Lowe SW, et al. Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 104: 8071-6. PMID 17470784 DOI: 10.1073/pnas.0702294104  0.44
2007 Scott CL, Gil J, Hernando E, Teruya-Feldstein J, Narita M, Martínez D, Visakorpi T, Mu D, Cordon-Cardo C, Peters G, Beach D, Lowe SW. Role of the chromobox protein CBX7 in lymphomagenesis. Proceedings of the National Academy of Sciences of the United States of America. 104: 5389-94. PMID 17374722 DOI: 10.1073/pnas.0608721104  0.32
2007 Karni R, de Stanchina E, Lowe SW, Sinha R, Mu D, Krainer AR. The gene encoding the splicing factor SF2/ASF is a proto-oncogene. Nature Structural & Molecular Biology. 14: 185-93. PMID 17310252 DOI: 10.1038/nsmb1209  0.44
2007 Xue W, Zender L, Miething C, Dickins RA, Hernando E, Krizhanovsky V, Cordon-Cardo C, Lowe SW. Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature. 445: 656-60. PMID 17251933 DOI: 10.1038/nature05529  0.32
2007 Sotillo R, Hernando E, Díaz-Rodríguez E, Teruya-Feldstein J, Cordón-Cardo C, Lowe SW, Benezra R. Mad2 overexpression promotes aneuploidy and tumorigenesis in mice. Cancer Cell. 11: 9-23. PMID 17189715 DOI: 10.1016/j.ccr.2006.10.019  0.32
2006 Geurts AM, Collier LS, Geurts JL, Oseth LL, Bell ML, Mu D, Lucito R, Godbout SA, Green LE, Lowe SW, Hirsch BA, Leinwand LA, Largaespada DA. Gene mutations and genomic rearrangements in the mouse as a result of transposon mobilization from chromosomal concatemers. Plos Genetics. 2: e156. PMID 17009875 DOI: 10.1371/journal.pgen.0020156  0.44
2006 Narita M, Narita M, Krizhanovsky V, Nuñez S, Chicas A, Hearn SA, Myers MP, Lowe SW. A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell. 126: 503-14. PMID 16901784 DOI: 10.1016/j.cell.2006.05.052  0.44
2006 Wendel HG, Malina A, Zhao Z, Zender L, Kogan SC, Cordon-Cardo C, Pelletier J, Lowe SW. Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo. Cancer Research. 66: 7639-46. PMID 16885364 DOI: 10.1158/0008-5472.CAN-06-0419  0.32
2006 Lakshmi B, Hall IM, Egan C, Alexander J, Leotta A, Healy J, Zender L, Spector MS, Xue W, Lowe SW, Wigler M, Lucito R. Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. Proceedings of the National Academy of Sciences of the United States of America. 103: 11234-9. PMID 16844783 DOI: 10.1073/pnas.0602984103  0.44
2006 Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell. 125: 1253-67. PMID 16814713 DOI: 10.1016/j.cell.2006.05.030  0.44
2006 Hemann MT, Lowe SW. The p53-Bcl-2 connection. Cell Death and Differentiation. 13: 1256-9. PMID 16710363 DOI: 10.1038/sj.cdd.4401962  0.44
2006 Wendel HG, De Stanchina E, Cepero E, Ray S, Emig M, Fridman JS, Veach DR, Bornmann WG, Clarkson B, McCombie WR, Kogan SC, Hochhaus A, Lowe SW. Loss of p53 impedes the antileukemic response to BCR-ABL inhibition Proceedings of the National Academy of Sciences of the United States of America. 103: 7444-7449. PMID 16651519 DOI: 10.1073/pnas.0602402103  0.44
2006 Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature. 440: 105-9. PMID 16400328 DOI: 10.1038/nature04495  0.44
2006 Mason DX, Keppler D, Zhang J, Jackson TJ, Seger YR, Matsui S, Abreo F, Cowell JK, Hannon GJ, Lowe SW, Lin AW. Defined genetic events associated with the spontaneous in vitro transformation of ElA/Ras-expressing human IMR90 fibroblasts. Carcinogenesis. 27: 350-9. PMID 16280331 DOI: 10.1093/carcin/bgi264  0.44
2005 Zender L, Xue W, Cordón-Cardo C, Hannon GJ, Lucito R, Powers S, Flemming P, Spector MS, Lowe SW. Generation and analysis of genetically defined liver carcinomas derived from bipotential liver progenitors. Cold Spring Harbor Symposia On Quantitative Biology. 70: 251-61. PMID 16869761 DOI: 10.1101/sqb.2005.70.059  0.32
2005 Dickins RA, Hemann MT, Zilfou JT, Simpson DR, Ibarra I, Hannon GJ, Lowe SW. Probing tumor phenotypes using stable and regulated synthetic microRNA precursors. Nature Genetics. 37: 1289-95. PMID 16200064 DOI: 10.1038/ng1651  0.44
2005 Hemann MT, Bric A, Teruya-Feldstein J, Herbst A, Nilsson JA, Cordon-Cardo C, Cleveland JL, Tansey WP, Lowe SW. Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants. Nature. 436: 807-11. PMID 16094360 DOI: 10.1038/nature03845  0.44
2005 He L, Thomson JM, Hemann MT, Hernando-Monge E, Mu D, Goodson S, Powers S, Cordon-Cardo C, Lowe SW, Hannon GJ, Hammond SM. A microRNA polycistron as a potential human oncogene. Nature. 435: 828-33. PMID 15944707 DOI: 10.1038/nature03552  0.44
2005 Helmrich A, Lee S, O'Brien P, Dörken B, Lowe SW, Schröck E, Schmitt CA. Recurrent chromosomal aberrations in INK4a/ARF defective primary lymphomas predict drug responses in vivo. Oncogene. 24: 4174-82. PMID 15824738 DOI: 10.1038/sj.onc.1208600  0.44
2005 Samuelson AV, Narita M, Chan HM, Jin J, de Stanchina E, McCurrach ME, Narita M, Fuchs M, Livingston DM, Lowe SW. p400 is required for E1A to promote apoptosis. The Journal of Biological Chemistry. 280: 21915-23. PMID 15741165 DOI: 10.1074/jbc.M414564200  0.44
2005 Finnberg N, Gruber JJ, Fei P, Rudolph D, Bric A, Kim SH, Burns TF, Ajuha H, Page R, Wu GS, Chen Y, McKenna WG, Bernhard E, Lowe S, Mak T, et al. DR5 knockout mice are compromised in radiation-induced apoptosis. Molecular and Cellular Biology. 25: 2000-13. PMID 15713653 DOI: 10.1128/MCB.25.5.2000-2013.2005  0.44
2005 Herbst A, Hemann MT, Tworkowski KA, Salghetti SE, Lowe SW, Tansey WP. A conserved element in Myc that negatively regulates its proapoptotic activity. Embo Reports. 6: 177-83. PMID 15678160 DOI: 10.1038/sj.embor.7400333  0.44
2005 Chan HM, Narita M, Lowe SW, Livingston DM. The p400 E1A-associated protein is a novel component of the p53 → p21 senescence pathway Genes and Development. 19: 196-201. PMID 15655109 DOI: 10.1101/gad.1280205  0.44
2004 Hernando E, Nahlé Z, Juan G, Diaz-Rodriguez E, Alaminos M, Hemann M, Michel L, Mittal V, Gerald W, Benezra R, Lowe SW, Cordon-Cardo C. Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control. Nature. 430: 797-802. PMID 15306814 DOI: 10.1038/nature02820  0.44
2004 Hemann MT, Zilfou JT, Zhao Z, Burgess DJ, Hannon GJ, Lowe SW. Suppression of tumorigenesis by the p53 target PUMA. Proceedings of the National Academy of Sciences of the United States of America. 101: 9333-8. PMID 15192153 DOI: 10.1073/pnas.0403286101  0.44
2004 de Stanchina E, Querido E, Narita M, Davuluri RV, Pandolfi PP, Ferbeyre G, Lowe SW. PML is a direct p53 target that modulates p53 effector functions. Molecular Cell. 13: 523-35. PMID 14992722 DOI: 10.1016/S1097-2765(04)00062-0  0.44
2003 Narita M, N?nez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, Lowe SW. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell. 113: 703-16. PMID 12809602 DOI: 10.1016/S0092-8674(03)00401-X  0.44
2003 Mu D, Chen L, Zhang X, See LH, Koch CM, Yen C, Tong JJ, Spiegel L, Nguyen KC, Servoss A, Peng Y, Pei L, Marks JR, Lowe S, Hoey T, et al. Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. Cancer Cell. 3: 297-302. PMID 12676587 DOI: 10.1016/S1535-6108(03)00054-0  0.44
2003 Lowe SW, Sherr CJ. Tumor suppression by Ink4a-Arf: progress and puzzles. Current Opinion in Genetics & Development. 13: 77-83. PMID 12573439 DOI: 10.1016/S0959-437X(02)00013-8  0.44
2003 Hemann MT, Fridman JS, Zilfou JT, Hernando E, Paddison PJ, Cordon-Cardo C, Hannon GJ, Lowe SW. An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo. Nature Genetics. 33: 396-400. PMID 12567186 DOI: 10.1038/ng1091  0.44
2002 Nahle Z, Polakoff J, Davuluri RV, McCurrach ME, Jacobson MD, Narita M, Zhang MQ, Lazebnik Y, Bar-Sagi D, Lowe SW. Direct coupling of the cell cycle and cell death machinery by E2F. Nature Cell Biology. 4: 859-64. PMID 12389032 DOI: 10.1038/ncb868  0.44
2002 Hirao A, Cheung A, Duncan G, Girard PM, Elia AJ, Wakeham A, Okada H, Sarkissian T, Wong JA, Sakai T, De Stanchina E, Bristow RG, Suda T, Lowe SW, Jeggo PA, et al. Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Molecular and Cellular Biology. 22: 6521-32. PMID 12192050 DOI: 10.1128/MCB.22.18.6521-6532.2002  0.44
2002 Schmitt CA, Fridman JS, Yang M, Baranov E, Hoffman RM, Lowe SW. Dissecting p53 tumor suppressor functions in vivo. Cancer Cell. 1: 289-98. PMID 12086865 DOI: 10.1016/S1535-6108(02)00047-8  0.44
2002 Li J, Yang Y, Peng Y, Austin RJ, van Eyndhoven WG, Nguyen KC, Gabriele T, McCurrach ME, Marks JR, Hoey T, Lowe SW, Powers S. Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23. Nature Genetics. 31: 133-4. PMID 12021784 DOI: 10.1038/ng888  0.44
2002 Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, Lowe SW. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell. 109: 335-46. PMID 12015983 DOI: 10.1016/S0092-8674(02)00734-1  0.44
2002 Okada H, Suh WK, Jin J, Woo M, Du C, Elia A, Duncan GS, Wakeham A, Itie A, Lowe SW, Wang X, Mak TW. Generation and characterization of Smac/DIABLO-deficient mice. Molecular and Cellular Biology. 22: 3509-17. PMID 11971981 DOI: 10.1128/MCB.22.10.3509-3517.2002  0.44
2002 Ferbeyre G, de Stanchina E, Lin AW, Querido E, McCurrach ME, Hannon GJ, Lowe SW. Oncogenic ras and p53 cooperate to induce cellular senescence. Molecular and Cellular Biology. 22: 3497-508. PMID 11971980 DOI: 10.1128/MCB.22.10.3497-3508.2002  0.44
2002 Schmitt CA, Lowe SW. Apoptosis and chemoresistance in transgenic cancer models. Journal of Molecular Medicine (Berlin, Germany). 80: 137-46. PMID 11894140 DOI: 10.1007/s00109-001-0293-3  0.44
2002 Ferbeyre G, Lowe SW. The price of tumour suppression? Nature. 415: 26-7. PMID 11780097 DOI: 10.1038/415026a  0.44
2001 Lin AW, Lowe SW. Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. Proceedings of the National Academy of Sciences of the United States of America. 98: 5025-30. PMID 11309506 DOI: 10.1073/pnas.091100298  0.44
2000 Schmitt CA, Wallace-Brodeur RR, Rosenthal CT, McCurrach ME, Lowe SW. DNA damage responses and chemosensitivity in the E mu-myc mouse lymphoma model. Cold Spring Harbor Symposia On Quantitative Biology. 65: 499-510. PMID 12760067 DOI: 10.1101/SQB.2000.65.499  0.44
2000 Nakaya N, Lowe SW, Taya Y, Chenchik A, Enikolopov G. Specific pattern of p53 phosphorylation during nitric oxide-induced cell cycle arrest. Oncogene. 19: 6369-75. PMID 11175352 DOI: 10.1038/sj.onc.1204100  0.44
2000 Schmitt CA, Rosenthal CT, Lowe SW. Genetic analysis of chemoresistance in primary murine lymphomas. Nature Medicine. 6: 1029-35. PMID 10973324 DOI: 10.1038/79542  0.44
2000 Ferbeyre G, De Stanchina E, Querido E, Baptiste N, Prives C, Lowe SW. PML is induced by oncogenic ras and promotes premature senescence Genes and Development. 14: 2015-2027. PMID 10950866  0.44
2000 Attardi LD, Reczek EE, Cosmas C, Demicco EG, McCurrach ME, Lowe SW, Jacks T. PERP, an apoptosis-associated target of p53, in a novel member of the PMP-22/gas3 family Genes and Development. 14: 704-718. PMID 10733530  0.44
2000 Lowe SW, Lin AW. Apoptosis in cancer. Carcinogenesis. 21: 485-95. PMID 10688869 DOI: 10.1093/CARCIN/21.3.485  0.44
1999 Schmitt CA, McCurrach ME, de Stanchina E, Wallace-Brodeur RR, Lowe SW. INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53. Genes & Development. 13: 2670-7. PMID 10541553 DOI: 10.1101/gad.13.20.2670  0.44
1998 Lin AW, Barradas M, Stone JC, van Aelst L, Serrano M, Lowe SW. Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling. Genes & Development. 12: 3008-19. PMID 9765203  0.44
1998 Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, Potter J, Yoshida R, Kaufman SA, Lowe SW, Penninger JM, et al. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 94: 339-52. PMID 9708736 DOI: 10.1016/S0092-8674(00)81477-4  0.44
1998 de Stanchina E, McCurrach ME, Zindy F, Shieh SY, Ferbeyre G, Samuelson AV, Prives C, Roussel MF, Sherr CJ, Lowe SW. E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes & Development. 12: 2434-42. PMID 9694807  0.44
1998 Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kägi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW, Mak TW. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes & Development. 12: 806-19. PMID 9512515 DOI: 10.1101/gad.12.6.806  0.44
1997 Lanni JS, Lowe SW, Licitra EJ, Liu JO, Jacks T. p53-independent apoptosis induced by paclitaxel through an indirect mechanism Proceedings of the National Academy of Sciences of the United States of America. 94: 9679-9683. PMID 9275183 DOI: 10.1073/pnas.94.18.9679  0.44
1997 McCurrach ME, Connor TM, Knudson CM, Korsmeyer SJ, Lowe SW. bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 94: 2345-9. PMID 9122197 DOI: 10.1073/pnas.94.6.2345  0.4
1997 Serrano M, Lin AW, McCurrach ME, Beach D, Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 88: 593-602. PMID 9054499 DOI: 10.1016/S0092-8674(00)81902-9  0.44
1996 Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 379: 88-91. PMID 8538748 DOI: 10.1038/379088a0  0.44
1994 Lowe SW, Jacks T, Housman DE, Ruley HE. Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells. Proceedings of the National Academy of Sciences of the United States of America. 91: 2026-30. PMID 8134344  0.44
1994 Lowe SW, Bodis S, McClatchey A, Remington L, Ruley HE, Fisher DE, Housman DE, Jacks T. p53 status and the efficacy of cancer therapy in vivo. Science (New York, N.Y.). 266: 807-10. PMID 7973635  0.44
1994 Lowe SW, Bodis S, Bardeesy N, McClatchey A, Remington L, Ruley HE, Fisher DE, Jacks T, Pelletier J, Housman DE. Apoptosis and the prognostic significance of p53 mutation. Cold Spring Harbor Symposia On Quantitative Biology. 59: 419-26. PMID 7587096  0.44
1993 Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 362: 847-9. PMID 8479522 DOI: 10.1038/362847a0  0.4
1993 Lowe SW, Ruley HE, Jacks T, Housman DE. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 74: 957-67. PMID 8402885 DOI: 10.1016/0092-8674(93)90719-7  0.44
1993 Lowe SW, Ruley HE. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes & Development. 7: 535-45. PMID 8384579  0.44
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