Guillermina Lozano - Publications

The University of Texas Graduate School of Biomedical Sciences at Houston 
Molecular Biology, Cell Biology

117 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Pant V, Xiong S, Wasylishen AR, Larsson CA, Aryal NK, Chau G, Tailor RC, Lozano G. Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity. Proceedings of the National Academy of Sciences of the United States of America. PMID 31409715 DOI: 10.1073/pnas.1909550116  0.48
2019 Aryal NK, Pant V, Wasylishen AR, Rimel B, Baseler L, El-Naggar AK, Mutch DG, Goodfellow PJ, Arur S, Lozano G. Dicer1 phospho-mimetic promotes tumor progression and dissemination. Cancer Research. PMID 30914430 DOI: 10.1158/0008-5472.CAN-18-2460  0.72
2018 Aryal NK, Pant V, Wasylishen AR, Parker-Thornburg J, Baseler L, El-Naggar AK, Liu B, Kalia A, Lozano G, Arur S. Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 30593561 DOI: 10.1073/pnas.1814377116  0.72
2018 Zhang Y, Xiong S, Liu B, Pant V, Celii F, Chau G, Elizondo-Fraire AC, Yang P, You MJ, El-Naggar AK, Navin NE, Lozano G. Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases. Nature Communications. 9: 3953. PMID 30262850 DOI: 10.1038/s41467-018-06146-9  1
2018 Wasylishen AR, Estrella JS, Pant V, Chau GP, Lozano G. Daxx Functions are p53-independent In Vivo. Molecular Cancer Research : McR. PMID 29903771 DOI: 10.1158/1541-7786.MCR-18-0281  0.64
2018 Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro-Pando S, Montiel MF, Chang K, Jiang Z, Ling J, Gupta S, Horne W, Pruski M, Wang H, Sun SC, ... Lozano G, et al. Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. Gastroenterology. PMID 29604293 DOI: 10.1053/j.gastro.2018.03.041  1
2018 Dibra D, Xia X, Gagea M, Lozano G, Li S. A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53. Plos One. 13: e0193485. PMID 29494633 DOI: 10.1371/journal.pone.0193485  0.36
2018 Larsson CA, Moyer SM, Liu B, Michel KA, Pant V, Yang P, Wong J, El-Naggar AK, Krahe R, Lozano G. Synergistic and additive effect of retinoic acid in circumventing resistance to p53 restoration. Proceedings of the National Academy of Sciences of the United States of America. PMID 29440484 DOI: 10.1073/pnas.1719001115  0.72
2017 Zhang Y, Lozano G. p53: Multiple Facets of a Rubik's Cube. Annual Review of Cancer Biology. 1: 185-201. PMID 30775651 DOI: 10.1146/annurev-cancerbio-050216-121926  1
2017 Aryal NK, Wasylishen AR, Pant V, Riley-Croce M, Lozano G. Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53. Oncotarget. 8: 103996-104006. PMID 29262616 DOI: 10.18632/oncotarget.22087  0.48
2017 Liu B, Mitani Y, Rao X, Zafereo M, Zhang J, Zhang J, Futreal PA, Lozano G, El-Naggar AK. Spatio-Temporal Genomic Heterogeneity, Phylogeny, and Metastatic Evolution in Salivary Adenoid Cystic Carcinoma. Journal of the National Cancer Institute. 109. PMID 29117356 DOI: 10.1093/jnci/djx033  0.72
2017 Kim MP, Lozano G. Mutant p53 partners in crime. Cell Death and Differentiation. PMID 29099488 DOI: 10.1038/cdd.2017.185  1
2017 Pourebrahim R, Zhang Y, Liu B, Gao R, Xiong S, Lin PP, McArthur MJ, Ostrowski MC, Lozano G. Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein. Genes & Development. PMID 29021240 DOI: 10.1101/gad.304972.117  1
2017 Pant V, Larsson CA, Aryal N, Xiong S, You MJ, Quintas-Cardama A, Lozano G. Tumorigenesis promotes Mdm4-S overexpression. Oncotarget. 8: 25837-25847. PMID 28460439 DOI: 10.18632/oncotarget.15552  0.48
2017 Jackson JG, Lozano G. TNBC invasion: downstream of STAT3. Oncotarget. PMID 28199968 DOI: 10.18632/oncotarget.15259  0.4
2016 Xiong S, Pant V, Zhang Y, Aryal NK, James You M, Kusewitt D, Lozano G. The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumorigenesis. The Journal of Pathology. PMID 27925213 DOI: 10.1002/path.4854  1
2016 Tonnessen-Murray CA, Lozano G, Jackson JG. The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence. Cold Spring Harbor Perspectives in Medicine. PMID 27881444 DOI: 10.1101/cshperspect.a026112  0.4
2016 Wasylishen AR, Lozano G. Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End. Cold Spring Harbor Perspectives in Medicine. PMID 27329033 DOI: 10.1101/cshperspect.a026211  0.56
2016 Dibra D, Mitra A, Newman M, Xia X, Cutrera JJ, Gagea M, Kleinerman ES, Lozano G, Li S. Lack of immunomodulatory Interleukin-27 enhances oncogenic properties of mutant p53 in vivo. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26979394 DOI: 10.1158/1078-0432.CCR-15-2052  0.56
2015 Wienken M, Dickmanns A, Nemajerova A, Kramer D, Najafova Z, Weiss M, Karpiuk O, Kassem M, Zhang Y, Lozano G, Johnsen SA, Moll UM, Zhang X, Dobbelstein M. MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53. Molecular Cell. PMID 26748827 DOI: 10.1016/j.molcel.2015.12.008  1
2015 Dibra D, Xia X, Mitra A, Cutrera JJ, Lozano G, Li S. Mutant p53 in concert with an IL27 Receptor α deficiency causes spontaneous liver inflammation, fibrosis, and steatosis. Hepatology (Baltimore, Md.). PMID 26637970 DOI: 10.1002/hep.28379  0.56
2015 Mitani Y, Liu B, Rao P, Borra V, Zafereo M, Weber RS, Kies MS, Lozano G, Futreal A, Caulin C, El-Naggar A. Novel MYBL1 gene rearrangements with recurrent MYBL1-NFIB fusions in salivary adenoid cystic carcinomas lacking t(6;9) translocations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26631609 DOI: 10.1158/1078-0432.CCR-15-2867-T  0.56
2015 Kim MP, Zhang Y, Lozano G. Mutant p53: Multiple Mechanisms Define Biologic Activity in Cancer. Frontiers in Oncology. 5: 249. PMID 26618142 DOI: 10.3389/fonc.2015.00249  1
2015 Tashakori M, Zhang Y, Xiong S, You MJ, Lozano G. p53 Activity Dominates that of p73 upon Mdm4 Loss in Development and Tumorigenesis. Molecular Cancer Research : McR. PMID 26527653 DOI: 10.1158/1541-7786.MCR-15-0346  0.56
2015 Goh AM, Xue Y, Leushacke M, Li L, Wong JS, Chiam PC, Rahmat SA, Mann MB, Mann KM, Barker N, Lozano G, Terzian T, Lane DP. Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice. Oncotarget. 6: 17968-80. PMID 26255629  0.56
2015 Jiang S, Minter LC, Stratton SA, Yang P, Abbas HA, Akdemir ZC, Pant V, Post S, Gagea M, Lee RG, Lozano G, Barton MC. TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice. Journal of Hepatology. 62: 371-9. PMID 25281858 DOI: 10.1016/j.jhep.2014.09.026  0.56
2014 Pant V, Lozano G. Limiting the power of p53 through the ubiquitin proteasome pathway. Genes & Development. 28: 1739-51. PMID 25128494 DOI: 10.1101/gad.247452.114  0.56
2014 Xiong S, Tu H, Kollareddy M, Pant V, Li Q, Zhang Y, Jackson JG, Suh YA, Elizondo-Fraire AC, Yang P, Chau G, Tashakori M, Wasylishen AR, Ju Z, Solomon H, ... ... Lozano G, et al. Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proceedings of the National Academy of Sciences of the United States of America. 111: 11145-50. PMID 25024203 DOI: 10.1073/pnas.1404139111  0.56
2014 Quintás-Cardama A, Post SM, Solis LM, Xiong S, Yang P, Chen N, Wistuba II, Killary AM, Lozano G. Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer. The Journal of Pathology. 234: 108-19. PMID 24890125 DOI: 10.1002/path.4385  0.56
2014 Yokoyama M, Okada S, Nakagomi A, Moriya J, Shimizu I, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, Minamino T. Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity. Cell Reports. 7: 1691-703. PMID 24857662 DOI: 10.1016/j.celrep.2014.04.046  0.56
2014 Zhang Y, Xiong S, Li Q, Hu S, Tashakori M, Van Pelt C, You MJ, Pageon L, Lozano G. Tissue-specific and age-dependent effects of global Mdm2 loss. The Journal of Pathology. 233: 380-91. PMID 24789767 DOI: 10.1002/path.4368  1
2014 Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou X, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC. USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nature Immunology. 15: 562-70. PMID 24777531 DOI: 10.1038/ni.2885  0.56
2014 Pant V, Lozano G. Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity. Oncotarget. 5: 1149-56. PMID 24658419 DOI: 10.18632/oncotarget.1797  0.56
2014 Ma J, Xiong M, You M, Lozano G, Amos CI. Genome-wide association tests of inversions with application to psoriasis. Human Genetics. 133: 967-74. PMID 24623382 DOI: 10.1007/s00439-014-1437-1  0.56
2014 Li Q, Zhang Y, El-Naggar AK, Xiong S, Yang P, Jackson JG, Chau G, Lozano G. Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors. Molecular Cancer Research : McR. 12: 901-11. PMID 24598047 DOI: 10.1158/1541-7786.MCR-14-0089  0.56
2013 Tordella L, Koch S, Salter V, Pagotto A, Doondeea JB, Feller SM, Ratnayaka I, Zhong S, Goldin RD, Lozano G, McKeon FD, Tavassoli M, Fritzsche F, Huber GF, Rössle M, et al. ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63. Proceedings of the National Academy of Sciences of the United States of America. 110: 17969-74. PMID 24127607 DOI: 10.1073/pnas.1309362110  0.56
2013 Pant V, Xiong S, Jackson JG, Post SM, Abbas HA, Quintás-Cardama A, Hamir AN, Lozano G. The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity. Genes & Development. 27: 1857-67. PMID 23973961 DOI: 10.1101/gad.227249.113  0.56
2013 Chen N, Balasenthil S, Reuther J, Frayna A, Wang Y, Chandler DS, Abruzzo LV, Rashid A, Rodriguez J, Lozano G, Cao Y, Lokken E, Chen J, Frazier ML, Sahin AA, et al. DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-β-driven epithelial-mesenchymal transition. Cancer Discovery. 3: 1172-89. PMID 23838884 DOI: 10.1158/2159-8290.CD-12-0499  0.56
2013 Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Rozenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, et al. Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell. 23: 634-46. PMID 23680148 DOI: 10.1016/j.ccr.2013.03.022  0.56
2013 Li Q, Lozano G. Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 34-41. PMID 23262034 DOI: 10.1158/1078-0432.CCR-12-0053  0.48
2012 Pant V, Quintás-Cardama A, Lozano G. The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans. Blood. 120: 5118-27. PMID 23018641 DOI: 10.1182/blood-2012-05-356014  0.56
2012 Flores ER, Lozano G. The p53 family grows old. Genes & Development. 26: 1997-2000. PMID 22987633 DOI: 10.1101/gad.202648.112  0.56
2012 Cantley LC, Dalton WS, DuBois RN, Finn OJ, Futreal PA, Golub TR, Hait WN, Lozano G, Maris JM, Nelson WG, Sawyers CL, Schreiber SL, Spitz MR, Steeg PS. AACR Cancer Progress Report 2012. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: S1-100. PMID 22977188 DOI: 10.1158/1078-0432.CCR-12-2891  0.56
2012 Jackson JG, Lozano G. Che-ating death: CHE1/AATF protects from p53-mediated apoptosis. The Embo Journal. 31: 3951-3. PMID 22960635 DOI: 10.1038/emboj.2012.258  0.56
2012 Jackson JG, Pant V, Li Q, Chang LL, Quintás-Cardama A, Garza D, Tavana O, Yang P, Manshouri T, Li Y, El-Naggar AK, Lozano G. p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell. 21: 793-806. PMID 22698404 DOI: 10.1016/j.ccr.2012.04.027  0.56
2012 Xiong S, Parker-Thornburg J, Lozano G. Developing genetically engineered mouse models to study tumor suppression. Current Protocols in Mouse Biology. 2: 9-24. PMID 22582146 DOI: 10.1002/9780470942390.mo110159  0.48
2011 Suh YA, Post SM, Elizondo-Fraire AC, Maccio DR, Jackson JG, El-Naggar AK, Van Pelt C, Terzian T, Lozano G. Multiple stress signals activate mutant p53 in vivo. Cancer Research. 71: 7168-75. PMID 21983037 DOI: 10.1158/0008-5472.CAN-11-0459  0.56
2011 Abbas HA, Pant V, Lozano G. The ups and downs of p53 regulation in hematopoietic stem cells. Cell Cycle (Georgetown, Tex.). 10: 3257-62. PMID 21957490 DOI: 10.4161/cc.10.19.17721  0.56
2011 McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, et al. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell. 20: 260-75. PMID 21840489 DOI: 10.1016/j.ccr.2011.07.005  0.56
2011 Girardini JE, Napoli M, Piazza S, Rustighi A, Marotta C, Radaelli E, Capaci V, Jordan L, Quinlan P, Thompson A, Mano M, Rosato A, Crook T, Scanziani E, Means AR, ... Lozano G, et al. A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell. 20: 79-91. PMID 21741598 DOI: 10.1016/j.ccr.2011.06.004  0.56
2011 Pant V, Xiong S, Iwakuma T, Quintás-Cardama A, Lozano G. Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proceedings of the National Academy of Sciences of the United States of America. 108: 11995-2000. PMID 21730132 DOI: 10.1073/pnas.1102241108  0.56
2011 Terzian T, Dumble M, Arbab F, Thaller C, Donehower LA, Lozano G, Justice MJ, Roop DR, Box NF. Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. The Journal of Pathology. 224: 540-52. PMID 21674502 DOI: 10.1002/path.2891  0.52
2011 Williams MD, Zhang L, Elliott DD, Perrier ND, Lozano G, Clayman GL, El-Naggar AK. Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas. Human Pathology. 42: 1213-20. PMID 21420716 DOI: 10.1016/j.humpath.2010.12.006  0.72
2011 Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, ... ... Lozano G, et al. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. The Journal of Clinical Investigation. 121: 851-65. PMID 21317535 DOI: 10.1172/JCI44111  0.6
2011 Wu CC, Krahe R, Lozano G, Zhang B, Wilson CD, Jo EJ, Amos CI, Shete S, Strong LC. Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome. Human Genetics. 129: 663-73. PMID 21305319 DOI: 10.1007/s00439-011-0957-1  0.56
2011 Wang Y, Suh YA, Fuller MY, Jackson JG, Xiong S, Terzian T, Quintás-Cardama A, Bankson JA, El-Naggar AK, Lozano G. Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. The Journal of Clinical Investigation. 121: 893-904. PMID 21285512 DOI: 10.1172/JCI44504  0.56
2011 Jackson JG, Post SM, Lozano G. Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo. The Journal of Pathology. 223: 127-36. PMID 20957626 DOI: 10.1002/path.2783  0.56
2011 Lin PP, Wang Y, Lozano G. Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma. Sarcoma. 2011. PMID 20953407 DOI: 10.1155/2011/276463  0.72
2010 Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell. 7: 606-17. PMID 21040902 DOI: 10.1016/j.stem.2010.09.013  0.56
2010 Terzian T, Lozano G. Building p53. Genes & Development. 24: 2229-32. PMID 20952532 DOI: 10.1101/gad.1988510  0.52
2010 Addadi Y, Moskovits N, Granot D, Lozano G, Carmi Y, Apte RN, Neeman M, Oren M. p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner Cancer Research. 70: 9650-9658. PMID 20952507 DOI: 10.1158/0008-5472.CAN-10-1146  0.56
2010 Terzian T, Torchia EC, Dai D, Robinson SE, Murao K, Stiegmann RA, Gonzalez V, Boyle GM, Powell MB, Pollock PM, Lozano G, Robinson WA, Roop DR, Box NF. p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation. Pigment Cell & Melanoma Research. 23: 781-94. PMID 20849464 DOI: 10.1111/j.1755-148X.2010.00773.x  0.56
2010 Post SM, Quintás-Cardama A, Pant V, Iwakuma T, Hamir A, Jackson JG, Maccio DR, Bond GL, Johnson DG, Levine AJ, Lozano G. A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer Cell. 18: 220-30. PMID 20832750 DOI: 10.1016/j.ccr.2010.07.010  0.56
2010 Post SM, Lozano G. You can win by losing: p53 mutations in rhabdomyosarcomas. The Journal of Pathology. 222: 124-8. PMID 20821751 DOI: 10.1002/path.2757  0.48
2010 Xiong S, Pant V, Suh YA, Van Pelt CS, Wang Y, Valentin-Vega YA, Post SM, Lozano G. Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4. Cancer Research. 70: 7148-54. PMID 20736370 DOI: 10.1158/0008-5472.CAN-10-1457  0.56
2010 Fang S, Krahe R, Lozano G, Han Y, Chen W, Post SM, Zhang B, Wilson CD, Bachinski LL, Strong LC, Amos CI. Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations. Plos One. 5: e10813. PMID 20520810 DOI: 10.1371/journal.pone.0010813  0.56
2010 Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity. 32: 670-80. PMID 20493730 DOI: 10.1016/j.immuni.2010.05.002  0.56
2009 Donehower LA, Lozano G. 20 years studying p53 functions in genetically engineered mice. Nature Reviews. Cancer. 9: 831-41. PMID 19776746 DOI: 10.1038/nrc2731  0.32
2009 Lin PP, Pandey MK, Jin F, Raymond AK, Akiyama H, Lozano G. Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice. Carcinogenesis. 30: 1789-95. PMID 19635748 DOI: 10.1093/carcin/bgp180  0.72
2009 Gibbons DL, Lin W, Creighton CJ, Zheng S, Berel D, Yang Y, Raso MG, Liu DD, Wistuba II, Lozano G, Kurie JM. Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. Plos One. 4: e5401. PMID 19404390 DOI: 10.1371/journal.pone.0005401  0.56
2009 Valentin-Vega YA, Box N, Terzian T, Lozano G. Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities. Differentiation; Research in Biological Diversity. 77: 442-9. PMID 19371999 DOI: 10.1016/j.diff.2009.03.001  0.64
2008 Molchadsky A, Shats I, Goldfinger N, Pevsner-Fischer M, Olson M, Rinon A, Tzahor E, Lozano G, Zipori D, Sarig R, Rotter V. p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner. Plos One. 3: e3707. PMID 19002260 DOI: 10.1371/journal.pone.0003707  0.56
2008 Lin PP, Pandey MK, Jin F, Xiong S, Deavers M, Parant JM, Lozano G. EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Research. 68: 8968-75. PMID 18974141 DOI: 10.1158/0008-5472.CAN-08-0573  0.56
2008 Valentin-Vega YA, Okano H, Lozano G. The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival. Cell Death and Differentiation. 15: 1772-81. PMID 18636077 DOI: 10.1038/cdd.2008.109  0.64
2008 Barboza JA, Iwakuma T, Terzian T, El-Naggar AK, Lozano G. Mdm2 and Mdm4 loss regulates distinct p53 activities. Molecular Cancer Research : McR. 6: 947-54. PMID 18567799 DOI: 10.1158/1541-7786.MCR-07-2079  0.72
2008 Terzian T, Suh YA, Iwakuma T, Post SM, Neumann M, Lang GA, Van Pelt CS, Lozano G. The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss. Genes & Development. 22: 1337-44. PMID 18483220 DOI: 10.1101/gad.1662908  0.52
2008 Iwakuma T, Tochigi Y, Van Pelt CS, Caldwell LC, Terzian T, Parant JM, Chau GP, Koch JG, Eischen CM, Lozano G. Mtbp haploinsufficiency in mice increases tumor metastasis. Oncogene. 27: 1813-20. PMID 17906694 DOI: 10.1038/sj.onc.1210827  0.56
2007 Valentin-Vega YA, Barboza JA, Chau GP, El-Naggar AK, Lozano G. High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas. Human Pathology. 38: 1553-62. PMID 17651783 DOI: 10.1016/j.humpath.2007.03.005  0.72
2007 Koch JG, Gu X, Han Y, El-Naggar AK, Olson MV, Medina D, Jerry DJ, Blackburn AC, Peltz G, Amos CI, Lozano G. Mammary tumor modifiers in BALB/cJ mice heterozygous for p53. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 18: 300-9. PMID 17557176 DOI: 10.1007/s00335-007-9028-2  0.56
2007 Xiong S, Van Pelt CS, Elizondo-Fraire AC, Fernandez-Garcia B, Lozano G. Loss of Mdm4 results in p53-dependent dilated cardiomyopathy. Circulation. 115: 2925-30. PMID 17533180 DOI: 10.1161/CIRCULATIONAHA.107.689901  0.48
2007 Terzian T, Wang Y, Van Pelt CS, Box NF, Travis EL, Lozano G. Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development. Molecular and Cellular Biology. 27: 5479-85. PMID 17526734 DOI: 10.1128/MCB.00555-06  0.72
2007 Zheng S, El-Naggar AK, Kim ES, Kurie JM, Lozano G. A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene. 26: 6896-904. PMID 17486075 DOI: 10.1038/sj.onc.1210493  0.72
2007 Cosme-Blanco W, Shen MF, Lazar AJ, Pathak S, Lozano G, Multani AS, Chang S. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. Embo Reports. 8: 497-503. PMID 17396137 DOI: 10.1038/sj.embor.7400937  0.56
2007 Han X, Garcia-Manero G, McDonnell TJ, Lozano G, Medeiros LJ, Xiao L, Rosner G, Nguyen M, Fernandez M, Valentin-Vega YA, Barboza J, Jones DM, Rassidakis GZ, Kantarjian HM, Bueso-Ramos CE. HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 20: 54-62. PMID 17143258 DOI: 10.1038/modpathol.3800727  0.64
2006 Barboza JA, Liu G, Ju Z, El-Naggar AK, Lozano G. p21 delays tumor onset by preservation of chromosomal stability. Proceedings of the National Academy of Sciences of the United States of America. 103: 19842-7. PMID 17170138 DOI: 10.1073/pnas.0606343104  1
2006 Lee MH, Lozano G. Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins. Seminars in Cancer Biology. 16: 225-34. PMID 16697215 DOI: 10.1016/j.semcancer.2006.03.009  0.6
2006 Ayanga B, Price R, Gu X, Lozano G, Evans SC. Genetic mapping of a putative tumor suppressor locus that influences tumorigenesis and metastasis in mice. Genes, Chromosomes & Cancer. 45: 668-75. PMID 16586494 DOI: 10.1002/gcc.20328  0.56
2006 Xiong S, Van Pelt CS, Elizondo-Fraire AC, Liu G, Lozano G. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proceedings of the National Academy of Sciences of the United States of America. 103: 3226-31. PMID 16492743 DOI: 10.1073/pnas.0508500103  1
2006 Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Molecular and Cellular Biology. 26: 192-8. PMID 16354690 DOI: 10.1128/MCB.26.1.192-198.2006  0.56
2005 Lozano G, Zambetti GP. Gankyrin: an intriguing name for a novel regulator of p53 and RB. Cancer Cell. 8: 3-4. PMID 16023592 DOI: 10.1016/j.ccr.2005.06.014  0.56
2005 Iwakuma T, Lozano G, Flores ER. Li-Fraumeni syndrome: a p53 family affair. Cell Cycle (Georgetown, Tex.). 4: 865-7. PMID 15917654 DOI: 10.4161/cc.4.7.1800  0.56
2005 Huang W, Zhang J, Washington M, Liu J, Parant JM, Lozano G, Moore DD. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Molecular Endocrinology (Baltimore, Md.). 19: 1646-53. PMID 15831521 DOI: 10.1210/me.2004-0520  0.56
2005 Liu G, Lozano G. p21 stability: linking chaperones to a cell cycle checkpoint. Cancer Cell. 7: 113-4. PMID 15710322 DOI: 10.1016/j.ccr.2005.01.019  1
2005 Bachinski LL, Olufemi SE, Zhou X, Wu CC, Yip L, Shete S, Lozano G, Amos CI, Strong LC, Krahe R. Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23. Cancer Research. 65: 427-31. PMID 15695383  0.56
2005 Lozano G, Zambetti GP. What have animal models taught us about the p53 pathway? The Journal of Pathology. 205: 206-20. PMID 15643668 DOI: 10.1002/path.1704  0.56
2004 Lang GA, Iwakuma T, Suh YA, Liu G, Rao VA, Parant JM, Valentin-Vega YA, Terzian T, Caldwell LC, Strong LC, El-Naggar AK, Lozano G. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell. 119: 861-72. PMID 15607981 DOI: 10.1016/j.cell.2004.11.006  0.56
2004 Li Z, Day CP, Yang JY, Tsai WB, Lozano G, Shih HM, Hung MC. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Research. 64: 9080-5. PMID 15604276 DOI: 10.1158/0008-5472.CAN-04-2419  0.32
2004 Bond GL, Hu W, Bond EE, Robins H, Lutzker SG, Arva NC, Bargonetti J, Bartel F, Taubert H, Wuerl P, Onel K, Yip L, Hwang SJ, Strong LC, Lozano G, et al. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell. 119: 591-602. PMID 15550242 DOI: 10.1016/j.cell.2004.11.022  0.56
2004 Bruins W, Zwart E, Attardi LD, Iwakuma T, Hoogervorst EM, Beems RB, Miranda B, Van Oostrom CTM, Van Den Berg J, Van Den Aardweg GJ, Lozano G, Van Steeg H, Jacks T, De Vries A. Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389 Molecular and Cellular Biology. 24: 8884-8894. PMID 15456863 DOI: 10.1128/MCB.24.20.8884-8894.2004  0.56
2004 Iwakuma T, Parant JM, Fasulo M, Zwart E, Jacks T, de Vries A, Lozano G. Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice. Oncogene. 23: 7644-50. PMID 15361844 DOI: 10.1038/sj.onc.1207793  0.56
2004 Barlow JW, Mous M, Wiley JC, Varley JM, Lozano G, Strong LC, Malkin D. Germ line BAX alterations are infrequent in Li-Fraumeni syndrome. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 13: 1403-6. PMID 15298965  0.56
2004 Evans SC, Liang M, Amos C, Gu X, Lozano G. A novel genetic modifier of p53, mop1, results in embryonic lethality. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 15: 415-23. PMID 15181534 DOI: 10.1007/s00335-004-2327-y  0.56
2004 Liu G, Parant JM, Lang G, Chau P, Chavez-Reyes A, El-Naggar AK, Multani A, Chang S, Lozano G. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nature Genetics. 36: 63-8. PMID 14702042 DOI: 10.1038/ng1282  0.56
2004 Horn EJ, Albor A, Liu Y, El-Hizawi S, Vanderbeek GE, Babcock M, Bowden GT, Hennings H, Lozano G, Weinberg WC, Kulesz-Martin M. RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties Carcinogenesis. 25: 157-167. PMID 14578165 DOI: 10.1093/carcin/bgh003  0.56
2003 Iwakuma T, Lozano G. MDM2, an introduction. Molecular Cancer Research : McR. 1: 993-1000. PMID 14707282  0.48
2003 Chavez-Reyes A, Parant JM, Amelse LL, de Oca Luna RM, Korsmeyer SJ, Lozano G. Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Research. 63: 8664-9. PMID 14695178  0.56
2003 Yang HY, Wen YY, Chen CH, Lozano G, Lee MH. 14-3-3 sigma positively regulates p53 and suppresses tumor growth. Molecular and Cellular Biology. 23: 7096-107. PMID 14517281  0.6
2003 Hwang SJ, Cheng LS, Lozano G, Amos CI, Gu X, Strong LC. Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk. Human Genetics. 113: 238-43. PMID 12802680 DOI: 10.1007/s00439-003-0968-7  0.44
2003 Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell. 112: 779-91. PMID 12654245 DOI: 10.1016/S0092-8674(03)00193-4  0.56
2003 Parant JM, Lozano G. Disrupting TP53 in mouse models of human cancers. Human Mutation. 21: 321-6. PMID 12619119 DOI: 10.1002/humu.10186  0.56
2003 Hwang SJ, Lozano G, Amos CI, Strong LC. Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk. American Journal of Human Genetics. 72: 975-83. PMID 12610779 DOI: 10.1086/374567  0.44
2003 Lu X, Lozano G, Donehower LA. Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system. Mutation Research. 522: 69-83. PMID 12517413  0.32
2002 Jabbur JR, Tabor AD, Cheng X, Wang H, Uesugi M, Lozano G, Zhang W. Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Oncogene. 21: 7100-13. PMID 12370832 DOI: 10.1038/sj.onc.1205856  0.36
2002 Gu J, Kawai H, Nie L, Kitao H, Wiederschain D, Jochemsen AG, Parant J, Lozano G, Yuan ZM. Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. The Journal of Biological Chemistry. 277: 19251-4. PMID 11953423 DOI: 10.1074/jbc.C200150200  0.56
2002 Grier JD, Yan W, Lozano G. Conditional allele of mdm2 which encodes a p53 inhibitor. Genesis (New York, N.Y. : 2000). 32: 145-7. PMID 11857803 DOI: 10.1002/gene.10066  0.56
2001 Evans SC, Viswanathan M, Grier JD, Narayana M, El-Naggar AK, Lozano G. An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2. Oncogene. 20: 4041-9. PMID 11494132 DOI: 10.1038/sj.onc.1204533  0.56
2001 Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y, Lu H. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Molecular Cell. 7: 283-92. PMID 11239457 DOI: 10.1016/S1097-2765(01)00176-9  0.56
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