Drew M. Pardoll - Publications

Johns Hopkins University, Baltimore, MD 
Molecular Biology, Immunology, Cell Biology

279 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Pulliam T, Jani S, Jing L, Ryu H, Jojic A, Shasha C, Zhang J, Kulikauskas R, Church C, Garnett-Benson C, Gooley T, Chapuis A, Paulson K, Smith KN, Pardoll DM, et al. Circulating cancer-specific CD8 T cell frequency is associated with response to PD-1 blockade in Merkel cell carcinoma. Cell Reports. Medicine. 101412. PMID 38340723 DOI: 10.1016/j.xcrm.2024.101412  0.388
2024 Zheng Y, Lebid A, Chung L, Fu J, Wang X, Otrocol A, Zarif JC, Yu H, Llosa NJ, Pardoll DM. Targeting the activin receptor 1C on CD4+ T cells for cancer immunotherapy. Oncoimmunology. 13: 2297503. PMID 38235319 DOI: 10.1080/2162402X.2023.2297503  0.399
2023 Bergerud KMB, Berkseth M, Pardoll DM, Ganguly S, Kleinberg LR, Lawrence J, Odde DJ, Largaespada DA, Terezakis SA, Sloan L. Radiation Therapy and Myeloid-derived Suppressor Cells: Breaking Down Their Cancerous Partnership. International Journal of Radiation Oncology, Biology, Physics. PMID 38042450 DOI: 10.1016/j.ijrobp.2023.11.050  0.3
2023 Dykema AG, Zhang J, Cheung LS, Connor S, Zhang B, Zeng Z, Cherry CM, Li T, Caushi JX, Nishimoto M, Munoz AJ, Ji Z, Hou W, Zhan W, Singh D, ... ... Pardoll DM, et al. Lung tumor-infiltrating T have divergent transcriptional profiles and function linked to checkpoint blockade response. Science Immunology. 8: eadg1487. PMID 37713507 DOI: 10.1126/sciimmunol.adg1487  0.384
2023 Wright KM, DiNapoli SR, Miller MS, Aitana Azurmendi P, Zhao X, Yu Z, Chakrabarti M, Shi W, Douglass J, Hwang MS, Hsiue EH, Mog BJ, Pearlman AH, Paul S, Konig MF, ... Pardoll DM, et al. Hydrophobic interactions dominate the recognition of a KRAS G12V neoantigen. Nature Communications. 14: 5063. PMID 37604828 DOI: 10.1038/s41467-023-40821-w  0.616
2022 Schad SE, Chow A, Mangarin L, Pan H, Zhang J, Ceglia N, Caushi JX, Malandro N, Zappasodi R, Gigoux M, Hirschhorn D, Budhu S, Amisaki M, Arniella M, Redmond D, ... ... Pardoll D, et al. Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions. The Journal of Experimental Medicine. 219. PMID 35604411 DOI: 10.1084/jem.20212169  0.387
2022 Dykema AG, Zhang B, Woldemeskel BA, Garliss CC, Rashid R, Westlake T, Zhang L, Zhang J, Cheung LS, Caushi JX, Pardoll DM, Cox AL, Ji H, Smith KN, Blankson JN. SARS-CoV-2 vaccination diversifies the CD4+ spike-reactive T cell repertoire in patients with prior SARS-CoV-2 infection. Ebiomedicine. 80: 104048. PMID 35533495 DOI: 10.1016/j.ebiom.2022.104048  0.318
2022 Pearlman AH, Hwang MS, Konig MF, Hsiue EH, Douglass J, DiNapoli SR, Mog BJ, Bettegowda C, Pardoll DM, Gabelli SB, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S. Author Correction: Targeting public neoantigens for cancer immunotherapy. Nature Cancer. 2: 865-867. PMID 35122030 DOI: 10.1038/s43018-021-00246-0  0.614
2021 Pearlman AH, Hwang MS, Konig MF, Hsiue EH, Douglass J, DiNapoli SR, Mog BJ, Bettegowda C, Pardoll DM, Gabelli SB, Papadopoulos N, Kinzler KW, Vogelstein B, Zhou S. Targeting public neoantigens for cancer immunotherapy. Nature Cancer. 2: 487-497. PMID 34676374 DOI: 10.1038/s43018-021-00210-y  0.633
2021 Caushi JX, Zhang J, Ji Z, Vaghasia A, Zhang B, Hsiue EH, Mog BJ, Hou W, Justesen S, Blosser R, Tam A, Anagnostou V, Cottrell TR, Guo H, Chan HY, ... ... Pardoll DM, et al. Author Correction: Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers. Nature. PMID 34608287 DOI: 10.1038/s41586-021-03893-6  0.375
2021 Hwang MS, Miller MS, Thirawatananond P, Douglass J, Wright KM, Hsiue EH, Mog BJ, Aytenfisu TY, Murphy MB, Aitana Azurmendi P, Skora AD, Pearlman AH, Paul S, DiNapoli SR, Konig MF, ... ... Pardoll DM, et al. Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens. Nature Communications. 12: 5271. PMID 34489470 DOI: 10.1038/s41467-021-25605-4  0.683
2021 Caushi JX, Zhang J, Ji Z, Vaghasia A, Zhang B, Hsiue EH, Mog BJ, Hou W, Justesen S, Blosser R, Tam A, Anagnostou V, Cottrell TR, Guo H, Chan HY, ... ... Pardoll DM, et al. Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers. Nature. PMID 34290408 DOI: 10.1038/s41586-021-03752-4  0.526
2021 Dykema AG, Zhang B, Woldemeskel BA, Garliss CC, Cheung LS, Choudhury D, Zhang J, Aparicio L, Bom S, Rashid R, Caushi JX, Hsiue EH, Cascino K, Thompson EA, Kwaa AK, ... ... Pardoll DM, et al. Functional characterization of CD4+ T-cell receptors cross-reactive for SARS-CoV-2 and endemic coronaviruses. The Journal of Clinical Investigation. PMID 33830946 DOI: 10.1172/JCI146922  0.312
2021 Hwang MS, Mog BJ, Douglass J, Pearlman AH, Hsiue EH, Paul S, DiNapoli SR, Konig MF, Pardoll DM, Gabelli SB, Bettegowda C, Papadopoulos N, Vogelstein B, Zhou S, Kinzler KW. Targeting loss of heterozygosity for cancer-specific immunotherapy. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33731480 DOI: 10.1073/pnas.2022410118  0.688
2021 Paul S, Pearlman AH, Douglass J, Mog BJ, Hsiue EH, Hwang MS, DiNapoli SR, Konig MF, Brown PA, Wright KM, Sur S, Gabelli SB, Li Y, Ghiaur G, Pardoll D, et al. TCR beta chain-directed bispecific antibodies for the treatment of T-cell cancers. Science Translational Medicine. PMID 33649188 DOI: 10.1126/scitranslmed.abd3595  0.825
2021 Hsiue EH, Wright KM, Douglass J, Hwang MS, Mog BJ, Pearlman AH, Paul S, DiNapoli SR, Konig MF, Wang Q, Schaefer A, Miller MS, Skora AD, Azurmendi PA, Murphy MB, ... ... Pardoll DM, et al. Targeting a neoantigen derived from a common mutation. Science (New York, N.Y.). PMID 33649166 DOI: 10.1126/science.abc8697  0.678
2021 Douglass J, Hsiue EH, Mog BJ, Hwang MS, DiNapoli SR, Pearlman AH, Miller MS, Wright KM, Azurmendi PA, Wang Q, Paul S, Schaefer A, Skora AD, Molin MD, Konig MF, ... ... Pardoll DM, et al. Bispecific antibodies targeting mutant neoantigens. Science Immunology. 6. PMID 33649101 DOI: 10.1126/sciimmunol.abd5515  0.652
2020 Anagnostou V, Bruhm DC, Niknafs N, White JR, Shao XM, Sidhom JW, Stein J, Tsai HL, Wang H, Belcaid Z, Murray J, Balan A, Ferreira L, Ross-Macdonald P, Wind-Rotolo M, ... ... Pardoll DM, et al. Integrative Tumor and Immune Cell Multi-omic Analyses Predict Response to Immune Checkpoint Blockade in Melanoma. Cell Reports. Medicine. 1: 100139. PMID 33294860 DOI: 10.1016/j.xcrm.2020.100139  0.339
2020 Faust HJ, Zhang H, Han J, Wolf MT, Jeon OH, Sadtler K, Peña AN, Chung L, Maestas DR, Tam AJ, Pardoll DM, Campisi J, Housseau F, Zhou D, Bingham CO, et al. IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis. The Journal of Clinical Investigation. PMID 32955487 DOI: 10.1172/Jci134091  0.388
2020 Grasso CS, Tsoi J, Onyshchenko M, Abril-Rodriguez G, Ross-Macdonald P, Wind-Rotolo M, Champhekar A, Medina E, Torrejon DY, Shin DS, Tran P, Kim YJ, Puig-Saus C, Campbell K, Vega-Crespo A, ... ... Pardoll DM, et al. Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma. Cancer Cell. PMID 32916126 DOI: 10.1016/J.Ccell.2020.08.005  0.402
2020 Theodros D, Murter BM, Sidhom JW, Nirschl TR, Clark DJ, Chen L, Tam A, Blosser RL, Schwen ZR, Johnson MH, Pierorazio PM, Zhang H, Ganguly S, Pardoll DM, Zarif JC. High-Dimensional Cytometry (ExCYT) and Mass Spectrometry of myeloid infiltrate in clinically localized clear cell Renal Cell Carcinoma identifies novel potential myeloid targets for immunotherapy. Molecular & Cellular Proteomics : McP. PMID 32737216 DOI: 10.1074/Mcp.Ra120.002049  0.39
2020 Chen L, Oke T, Siegel N, Cojocaru G, Tam AJ, Blosser RL, Swailes J, Ligon JA, Lebid A, Morris C, Levin A, Rhee DS, Johnston FM, Greer JB, Meyer CF, ... ... Pardoll DM, et al. The Immunosuppressive Niche of Soft Tissue Sarcomas is Sustained by Tumor Associated Macrophages and Characterized by Intratumoral Tertiary Lymphoid Structures. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32332015 DOI: 10.1158/1078-0432.Ccr-19-3416  0.319
2020 Lebid A, Chung L, Pardoll DM, Pan F. YAP Attenuates CD8 T Cell-Mediated Anti-tumor Response. Frontiers in Immunology. 11: 580. PMID 32322254 DOI: 10.3389/Fimmu.2020.00580  0.494
2020 Chung L, Maestas DR, Lebid A, Mageau A, Rosson GD, Wu X, Wolf MT, Tam AJ, Vanderzee I, Wang X, Andorko JI, Zhang H, Narain R, Sadtler K, Fan H, ... ... Pardoll DM, et al. Interleukin 17 and senescent cells regulate the foreign body response to synthetic material implants in mice and humans. Science Translational Medicine. 12. PMID 32295900 DOI: 10.1126/Scitranslmed.Aax3799  0.375
2020 Lipson EJ, Naqvi FF, Loss MJ, Schollenberger MD, Pardoll DM, Moore J, Brennan DC. Kidney retransplantation after anti-programmed cell death-1 (PD-1)-related allograft rejection. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 32185872 DOI: 10.1111/Ajt.15856  0.364
2020 Topalian SL, Taube JM, Pardoll DM. Neoadjuvant checkpoint blockade for cancer immunotherapy. Science (New York, N.Y.). 367. PMID 32001626 DOI: 10.1126/Science.Aax0182  0.322
2020 Kumar R, Boyapati K, Thomas N, Topiwala D, Kanacharoen S, Owoyemi O, Coffey M, Carducci M, Markowski MC, Antonarakis ES, Pardoll D, Denmeade S, Kachhap SK. Abstract 2410: Supraphysiological androgens induce ferroptotic cell death in prostate cancer cells Cancer Research. 80: 2410-2410. DOI: 10.1158/1538-7445.Am2020-2410  0.385
2019 Zhang J, Ji Z, Caushi JX, El Asmar M, Anagnostou V, Cottrell TR, Chan HY, Suri P, Guo H, Merghoub T, Chaft JE, Reuss JE, Tam AJ, Blosser RL, Abu-Akeel M, ... ... Pardoll DM, et al. Compartmental analysis of T cell clonal dynamics as a function of pathologic response to neoadjuvant PD-1 blockade in resectable non-small cell lung cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31754049 DOI: 10.1158/1078-0432.Ccr-19-2931  0.396
2019 Chen S, Crabill GA, Pritchard TS, McMiller TL, Wei P, Pardoll DM, Pan F, Topalian SL. Mechanisms regulating PD-L1 expression on tumor and immune cells. Journal For Immunotherapy of Cancer. 7: 305. PMID 31730010 DOI: 10.1186/S40425-019-0770-2  0.362
2019 Stein JE, Lipson EJ, Cottrell TR, Forde PM, Anders RA, Cimino-Mathews A, Thompson ED, Allaf ME, Yarchoan M, Feliciano J, Wang H, Jaffee EM, Pardoll DM, Topalian SL, Taube JM. Pan-Tumor Pathologic Scoring of Response to PD-(L)1 Blockade. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 31672770 DOI: 10.1158/1078-0432.Ccr-19-2379  0.338
2019 Sommerfeld SD, Cherry C, Schwab RM, Chung L, Maestas DR, Laffont P, Stein JE, Tam A, Ganguly S, Housseau F, Taube JM, Pardoll DM, Cahan P, Elisseeff JH. Interleukin-36γ-producing macrophages drive IL-17-mediated fibrosis. Science Immunology. 4. PMID 31604843 DOI: 10.1126/Sciimmunol.Aax4783  0.372
2019 Sokol ES, Pavlick D, Frampton GM, Ross JS, Miller VA, Ali SM, Lotan TL, Pardoll DM, Chung JH, Antonarakis ES. Pan-Cancer Analysis of Loss-of-Function Alterations and Their Association with the Focal Tandem-Duplicator Phenotype. The Oncologist. PMID 31292271 DOI: 10.1634/Theoncologist.2019-0214  0.335
2019 Smith KN, Llosa NJ, Cottrell TR, Siegel N, Fan H, Suri P, Chan HY, Guo H, Oke T, Awan AH, Verde F, Danilova L, Anagnostou V, Tam AJ, Luber BS, ... ... Pardoll DM, et al. Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1 (Journal for Immuno Therapy of Cancer (2019) 7 (40) DOI: 10.1186/s40425-018-0492-x) Journal For Immunotherapy of Cancer. 7: 7. PMID 30841906 DOI: 10.1186/S40425_019_0547_7  0.52
2019 Smith KN, Llosa NJ, Cottrell TR, Siegel N, Fan H, Suri P, Chan HY, Guo H, Oke T, Awan AH, Verde F, Danilova L, Anagnostou V, Tam AJ, Luber BS, ... ... Pardoll DM, et al. Correction to: persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1. Journal For Immunotherapy of Cancer. 7: 63. PMID 30841906 DOI: 10.1186/S40425-019-0547-7  0.452
2019 Smith KN, Llosa NJ, Cottrell TR, Siegel N, Fan H, Suri P, Chan HY, Guo H, Oke T, Awan AH, Verde F, Danilova L, Anagnostou V, Tam AJ, Luber BS, ... ... Pardoll DM, et al. Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1. Journal For Immunotherapy of Cancer. 7: 40. PMID 30744692 DOI: 10.1186/S40425-018-0492-X  0.452
2019 Cheung LS, Fu J, Kumar P, Kumar A, Urbanowski ME, Ihms EA, Parveen S, Bullen CK, Patrick GJ, Harrison R, Murphy JR, Pardoll DM, Bishai WR. Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti-PD-1 in melanoma. Proceedings of the National Academy of Sciences of the United States of America. PMID 30718426 DOI: 10.1073/Pnas.1815087116  0.347
2019 Wolf MT, Ganguly S, Wang TL, Anderson CW, Sadtler K, Narain R, Cherry C, Parrillo AJ, Park BV, Wang G, Pan F, Sukumar S, Pardoll DM, Elisseeff JH. A biologic scaffold-associated type 2 immune microenvironment inhibits tumor formation and synergizes with checkpoint immunotherapy. Science Translational Medicine. 11. PMID 30700576 DOI: 10.1126/Scitranslmed.Aat7973  0.448
2019 Murter B, Pan X, Ophir E, Alteber Z, Azulay M, Sen R, Levy O, Dassa L, Vaknin I, Fridman-Kfir T, Salomon R, Ravet A, Tam A, Levin D, Vaknin Y, ... ... Pardoll D, et al. Mouse PVRIG Has CD8 T Cell-Specific Coinhibitory Functions and Dampens Antitumor Immunity. Cancer Immunology Research. PMID 30659055 DOI: 10.1158/2326-6066.CIR-18-0460  0.409
2019 Whelan S, Ophir E, Kotturi MF, Levy O, Ganguly S, Leung L, Vaknin I, Kumar S, Dassa L, Hansen K, Bernados D, Murter B, Soni A, Taube JM, Fader AN, ... ... Pardoll DM, et al. PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8 T-cell Function. Cancer Immunology Research. PMID 30659054 DOI: 10.1158/2326-6066.Cir-18-0442  0.633
2019 Mendonca J, Owoyemi O, Rosen M, Carducci M, Markowski M, Antonarakis E, Pardoll D, Denmeade S, Kachhap SK. Abstract 517: Supraphysiological androgens activate innate immune signaling in prostate cancer Immunology. DOI: 10.1158/1538-7445.Sabcs18-517  0.312
2019 Ligon JA, Oke TF, Choi W, Fong MH, Levin A, Rhee DS, Morris CD, Siegel N, Hsieu EH, Meyer CF, McConkey DJ, Anders RA, Pardoll DM, Llosa NJ. Abstract 4973: The immunosuppressive tumor microenvironment of metastatic osteosarcoma inhibits the cytotoxic effect of tumor-infiltrating lymphocytes Immunology. DOI: 10.1158/1538-7445.Sabcs18-4973  0.361
2019 Llosa N, Awan AH, Tam AJ, Fan H, Smith KN, Sears CL, Wang H, Pardoll DM, Anders RA, Housseau F. Abstract 2793: Mismatch repair proficient colorectal cancer and adaptive immunosuppression of endogenous anti-tumor immune response: Implications for immunotherapy Cancer Research. DOI: 10.1158/1538-7445.Sabcs18-2793  0.385
2019 Sloan L, Sen R, Doucet M, Blosser L, Shpitser I, Sherman E, San N, Cheng Z, Katulis L, Wemmer J, Kamson D, Jackson C, Hu C, McNutt T, Grossman S, ... ... Pardoll D, et al. RTHP-43 (LTBK-02). MULTI-TIME POINT EVALUATION OF PERIPHERAL BLOOD MYELOID-DERIVED SUPPRESSOR CELL AND LYMPHOCYTE POPULATIONS IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA RECEIVING ADJUVANT THERAPY Neuro-Oncology. 21: vi283-vi283. DOI: 10.1093/Neuonc/Noz219.1196  0.342
2019 Jackson C, Choi J, Zhang J, Piotrowski A, Walbert T, Desai A, Ahluwalia M, Nabors B, Ye X, Desideri S, Fisher J, Wen P, Grossman S, Smith K, Pardoll D, et al. IMMU-18. IMMUNOGENOMIC RESPONDER PHENOTYPE FROM A PHASE I TRIAL OF ANTI-LAG3 OR ANTI-CD137 ALONE AND IN COMBINATION WITH ANTI-PD-1 IN PATIENTS WITH RECURRENT GBM Neuro-Oncology. 21: vi122-vi123. DOI: 10.1093/Neuonc/Noz175.511  0.448
2019 Caushi J, Ji Z, Zhang J, Asmar ME, Anagnostou V, Cottrell T, Chan HY, Guo H, Merghoub T, Wolchok J, Naidoo J, Marrone K, Chaft J, Hellmann M, Gabrielson E, ... ... Pardoll D, et al. P2.04-24 Transcriptional Profiling of Neoantigen Specific T Cells in Resectable NSCLC Treated with Neoadjuvant Anti-PD-1 Journal of Thoracic Oncology. 14. DOI: 10.1016/J.Jtho.2019.08.1529  0.36
2018 Anagnostou V, Forde PM, White JR, Niknafs N, Hruban C, Naidoo J, Marrone KA, Sivakumar IKA, Bruhm DC, Rosner S, Phallen J, Leal A, Adleff V, Smith KN, Cottrell TR, ... ... Pardoll DM, et al. Dynamics of tumor and immune responses during immune checkpoint blockade in non-small cell lung cancer. Cancer Research. PMID 30541742 DOI: 10.1158/0008-5472.Can-18-1127  0.41
2018 Sadtler K, Wolf MT, Ganguly S, Moad CA, Chung L, Majumdar S, Housseau F, Pardoll DM, Elisseeff JH. Divergent immune responses to synthetic and biological scaffolds. Biomaterials. 192: 405-415. PMID 30500722 DOI: 10.1016/J.Biomaterials.2018.11.002  0.317
2018 Hung AL, Maxwell R, Theodros D, Belcaid Z, Mathios D, Luksik AS, Kim E, Wu A, Xia Y, Garzon-Muvdi T, Jackson C, Ye X, Tyler B, Selby M, Korman A, ... ... Pardoll DM, et al. TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM. Oncoimmunology. 7: e1466769. PMID 30221069 DOI: 10.1080/2162402X.2018.1466769  0.358
2018 Ni X, Tao J, Barbi J, Chen Q, Park BV, Li Z, Zhang N, Lebid A, Ramaswamy A, Wei P, Zheng Y, Zhang X, Wu X, Vignali PDA, Yang C, ... ... Pardoll D, et al. YAP is essential for Treg mediated suppression of anti-tumor immunity. Cancer Discovery. PMID 29907586 DOI: 10.1158/2159-8290.Cd-17-1124  0.452
2018 Danilova L, Anagnostou V, Caushi JX, Sidhom JW, Guo H, Chan HY, Suri P, Tam AJ, Zhang J, El Asmar M, Marrone KA, Naidoo J, Brahmer JR, Forde PM, Baras AS, ... ... Pardoll D, et al. The Mutation-Associated Neoantigen Functional Expansion of Specific T cells (MANAFEST) assay: a sensitive platform for monitoring antitumor immunity. Cancer Immunology Research. PMID 29895573 DOI: 10.1158/2326-6066.Cir-18-0129  0.461
2018 Garzon-Muvdi T, Theodros D, Luksik AS, Maxwell R, Kim E, Jackson CM, Belcaid Z, Ganguly S, Tyler B, Brem H, Pardoll DM, Lim M. Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma. Oncotarget. 9: 20681-20697. PMID 29755681 DOI: 10.18632/Oncotarget.25061  0.389
2018 Forde PM, Chaft JE, Smith KN, Anagnostou V, Cottrell TR, Hellmann MD, Zahurak M, Yang SC, Jones DR, Broderick S, Battafarano RJ, Velez MJ, Rekhtman N, Olah Z, Naidoo J, ... ... Pardoll DM, et al. Neoadjuvant PD-1 Blockade in Resectable Lung Cancer. The New England Journal of Medicine. PMID 29658848 DOI: 10.1056/Nejmoa1716078  0.395
2018 Zeng Q, Fu J, Korrer M, Gorbounov M, Murray PJ, Pardoll DM, Masica DL, Kim YJ. Caspase-1 from Human Myeloid Derived Suppressor Cells Can Promote T-cell independent Tumor Proliferation. Cancer Immunology Research. PMID 29653983 DOI: 10.1158/2326-6066.Cir-17-0543  0.436
2018 Francica BJ, Ghasemzadeh A, Desbien AL, Theodros D, Sivick KE, Reiner GL, Hix Glickman L, Marciscano AE, Sharabi AB, Leong ML, McWhirter SM, Dubensky TW, Pardoll DM, Drake CG. TNFalpha and radio-resistant stromal cells are essential for therapeutic efficacy of cyclic dinucleotide STING agonists in non-immunogenic tumors. Cancer Immunology Research. PMID 29472271 DOI: 10.1158/2326-6066.Cir-17-0263  0.436
2018 Cottrell TR, Stein JE, Chaft JE, Thompson ED, Rekhtman N, Anagnostou V, Smith KN, Duffield AS, Anders RA, Isbell JM, Jones DR, Cuda JD, Battafarano R, Yang SC, Illei PB, ... ... Pardoll DM, et al. Abstract LB-154: Pathologic features of response to neoadjuvant anti-PD-1 in resected non-small cell lung carcinoma (NSCLC): A proposal for quantitative immune-related pathologic response criteria (irPRC) Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Lb-154  0.363
2018 Wu A, Cardarelli P, Oyasu M, Menezes D, Ponath P, Cogswell J, Maxwell R, Luksik A, Hung A, Kim E, Belcaid Z, Brem H, Pardoll D, Lim M. Abstract 1736: The combination of CXCR4 and checkpoint receptor inhibition improves survival in an orthotopic murine glioma model Cancer Research. 78: 1736-1736. DOI: 10.1158/1538-7445.Am2018-1736  0.415
2018 Domingue JC, Llosa N, White J, Drewes JL, Craig C, Tomkovich SE, Jobin C, Ding H, Tam A, Pardoll D, Housseau F, Sears CL. 151 - Colonic Bacteria and the Tumor Immune Microenvironment of Colorectal Cancer Patients Gastroenterology. 154. DOI: 10.1016/S0016-5085(18)30609-7  0.363
2018 Maxwell R, Luksik A, Garzon-Muvdi T, Hung AL, Kim ES, Wu A, Xia Y, Belcaid Z, Gorelick N, Theodros D, Jackson C, Ye X, Tran PT, Redmond KJ, Brem H, ... Pardoll DM, et al. Impact of Corticosteroids on the Efficacy of Anti-PD-1 Therapy for Tumors Located Within or Outside the Central Nervous System International Journal of Radiation Oncology Biology Physics. 102. DOI: 10.1016/J.Ijrobp.2018.07.035  0.307
2017 Duffield AS, Ascierto ML, Anders RA, Taube JM, Meeker AK, Chen S, McMiller TL, Phillips NA, Xu H, Ogurtsova A, Berger AE, Pardoll DM, Topalian SL, Ambinder RF. Th17 immune microenvironment in Epstein-Barr virus-negative Hodgkin lymphoma: implications for immunotherapy. Blood Advances. 1: 1324-1334. PMID 29296775 DOI: 10.1182/Bloodadvances.2017007260  0.316
2017 Wilson DR, Sen R, Sunshine JC, Pardoll DM, Green JJ, Kim YJ. Biodegradable STING agonist nanoparticles for enhanced cancer immunotherapy. Nanomedicine : Nanotechnology, Biology, and Medicine. PMID 29127039 DOI: 10.1016/J.Nano.2017.10.013  0.363
2017 Muroyama Y, Nirschl TR, Kochel CM, Lopez-Bujanda Z, Theodros D, Mao W, Carrera-Haro MA, Ghasemzadeh A, Marciscano AE, Velarde E, Tam AJ, Thoburn CJ, Uddin M, Meeker AK, Anders RA, ... Pardoll DM, et al. Stereotactic radiotherapy increases functionally suppressive regulatory T cells in the tumor microenvironment. Cancer Immunology Research. PMID 28970196 DOI: 10.1158/2326-6066.Cir-17-0040  0.452
2017 Le DT, Durham JN, Smith KN, Wang H, Bartlett BR, Aulakh LK, Lu S, Kemberling H, Wilt C, Luber BS, Wong F, Azad NS, Rucki AA, Laheru D, Donehower R, ... ... Pardoll DM, et al. Mismatch-repair deficiency predicts response of solid tumors to PD-1 blockade. Science (New York, N.Y.). PMID 28596308 DOI: 10.1126/Science.Aan6733  0.49
2017 Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Slamon DJ, Wolchok JD, Pardoll DM, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 169: 361. PMID 28388418 DOI: 10.1016/J.Cell.2017.03.036  0.487
2017 Ascierto ML, Makohon-Moore A, Lipson EJ, Taube JM, McMiller TL, Berger AE, Fan J, Kaunitz G, Cottrell T, Kohutek Z, Favorov A, Makarov V, Riaz N, Chan TA, Cope L, ... ... Pardoll DM, et al. Transcriptional mechanisms of resistance to anti-PD-1 therapy. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 28193624 DOI: 10.1158/1078-0432.Ccr-17-0270  0.486
2017 Anagnostou V, Smith KN, Forde PM, Niknafs N, Bhattacharya R, White J, Adleff V, Phallen J, Wali N, Hruban C, Guthrie VB, Rodgers K, Naidoo J, Kang H, Sharfman W, ... ... Pardoll DM, et al. Abstract NG01: Evolution of neoantigen landscape during immune checkpoint blockade in non-small cell lung cancer Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Ng01  0.337
2017 Fu J, Sen R, Masica DL, Karchin R, Pardoll D, Kim Y. Abstract 3843: Autologous resconstitution of human cancer and immune system in vivo Cancer Research. 77: 3843-3843. DOI: 10.1158/1538-7445.Am2017-3843  0.34
2016 Anagnostou V, Smith KN, Forde PM, Niknafs N, Bhattacharya R, White J, Zhang T, Adleff V, Phallen J, Wali N, Hruban C, Guthrie VB, Rodgers K, Naidoo J, Kang H, ... ... Pardoll DM, et al. Evolution of Neoantigen Landscape During Immune Checkpoint Blockade in Non-Small Cell Lung Cancer. Cancer Discovery. PMID 28031159 DOI: 10.1158/2159-8290.Cd-16-0828  0.462
2016 Fu J, Sen R, Masica DL, Karchin R, Pardoll D, Walter V, Hayes DN, Chung CH, Kim YJ. Autologous reconstitution of human cancer and immune system in vivo. Oncotarget. PMID 28008146 DOI: 10.18632/Oncotarget.14026  0.301
2016 Mathios D, Kim JE, Mangraviti A, Phallen J, Park CK, Jackson CM, Garzon-Muvdi T, Kim E, Theodros D, Polanczyk M, Martin AM, Suk I, Ye X, Tyler B, Bettegowda C, ... ... Pardoll DM, et al. Anti-PD-1 antitumor immunity is enhanced by local and abrogated by systemic chemotherapy in GBM. Science Translational Medicine. 8: 370ra180. PMID 28003545 DOI: 10.1126/Scitranslmed.Aag2942  0.443
2016 Danilova L, Wang H, Sunshine J, Kaunitz GJ, Cottrell TR, Xu H, Esandrio J, Anders RA, Cope L, Pardoll DM, Drake CG, Taube JM. Association of PD-1/PD-L axis expression with cytolytic activity, mutational load, and prognosis in melanoma and other solid tumors. Proceedings of the National Academy of Sciences of the United States of America. PMID 27837027 DOI: 10.1073/Pnas.1607836113  0.309
2016 Sadtler K, Allen BW, Estrellas K, Housseau F, Pardoll DM, Elisseeff JH. The Scaffold Immune Microenvironment: Biomaterial-Mediated Immune Polarization in Traumatic and Non-Traumatic Applications. Tissue Engineering. Part A. PMID 27736323 DOI: 10.1089/Ten.Tea.2016.0304  0.38
2016 Park BV, Freeman ZT, Ghasemzadeh A, Chattergoon MA, Rutebemberwa A, Steigner J, Winter ME, Huynh TV, Sebald SM, Lee SJ, Pan F, Pardoll DM, Cox AL. TGF-β1-Mediated Smad3 Enhances PD-1 Expression on Antigen-Specific T Cells in Cancer. Cancer Discovery. PMID 27683557 DOI: 10.1158/2159-8290.Cd-15-1347  0.428
2016 Ascierto ML, McMiller TL, Berger AE, Danilova L, Anders RA, Netto GJ, Xu H, Pritchard TS, Fan J, Cheadle C, Cope L, Drake CG, Pardoll DM, Taube JM, Topalian SL. The Intratumoral Balance between Metabolic and Immunologic Gene Expression Is Associated with Anti-PD-1 Response in Patients with Renal Cell Carcinoma. Cancer Immunology Research. PMID 27491898 DOI: 10.1158/2326-6066.Cir-16-0072  0.362
2016 Yang HY, Barbi J, Wu CY, Zheng Y, Vignali PD, Wu X, Tao JH, Park BV, Bandara S, Novack L, Ni X, Yang X, Chang KY, Wu RC, Zhang J, ... ... Pardoll DM, et al. MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor. Immunity. 45: 83-93. PMID 27438767 DOI: 10.1016/J.Immuni.2016.06.022  0.331
2016 Patel MA, Kim JE, Theodros D, Tam A, Velarde E, Kochel CM, Francica B, Nirschl TR, Ghasemzadeh A, Mathios D, Harris-Bookman S, Jackson CC, Jackson C, Ye X, Tran PT, ... ... Pardoll DM, et al. Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma. Journal For Immunotherapy of Cancer. 4: 28. PMID 27190629 DOI: 10.1186/S40425-016-0132-2  0.384
2016 Sadtler K, Estrellas K, Allen BW, Wolf MT, Fan H, Tam AJ, Patel CH, Luber BS, Wang H, Wagner KR, Powell JD, Housseau F, Pardoll DM, Elisseeff JH. Developing a pro-regenerative biomaterial scaffold microenvironment requires T helper 2 cells. Science (New York, N.Y.). 352: 366-70. PMID 27081073 DOI: 10.1126/Science.Aad9272  0.332
2016 Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Slamon DJ, Wolchok JD, Pardoll DM, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 164: 1073. PMID 27064190 DOI: 10.1016/J.Cell.2015.10.020  0.487
2016 Lipson EJ, Bagnasco SM, Moore J, Jang S, Patel MJ, Zachary AA, Pardoll DM, Taube JM, Drake CG. Tumor Regression and Allograft Rejection after Administration of Anti-PD-1. The New England Journal of Medicine. 374: 896-898. PMID 26962927 DOI: 10.1056/Nejmc1509268  0.301
2016 Housseau F, Wu S, Wick EC, Fan H, Wu X, Llosa NJ, Smith KN, Tam A, Ganguly S, Wanyiri JW, Iyadorai T, Malik AA, Roslani AC, Vadivelu JS, Van Meerbeke S, ... ... Pardoll DM, et al. Redundant innate and adaptive sources of IL-17 production drive colon tumorigenesis. Cancer Research. PMID 26880802 DOI: 10.1158/0008-5472.Can-15-0749  0.404
2016 Forde PM, Smith K, Chaft JE, Hellmann MD, Merghoub T, Wolchok JD, Yang SC, Battafarano RJ, Gabrielson E, Georgiades C, Verde F, Rosner GL, Anagnostou V, Velculescu VE, Topalian SL, ... Pardoll DM, et al. Neoadjuvant anti-PD1, nivolumab, in early stage resectable non-small-cell lung cancer. Journal of Clinical Oncology. 34: e20005-e20005. DOI: 10.1200/Jco.2016.34.15_Suppl.E20005  0.318
2016 Llosa NJ, Housseau F, Wick E, Lizzy H, Cruise M, Anders R, Sears C, Pardoll DM, Fan H, Siegel N, Blosser L, Tam A, Wang H. Abstract A141: The vigorous immune microenvironment of microsatellite instable colon cancer isbalanced by multiple counter-inhibitory checkpoints Cancer Immunology Research. 4. DOI: 10.1158/2326-6074.Cricimteatiaacr15-A141  0.443
2016 Zeng Q, Qualliotine JR, Blosser L, Pardoll D, Kim YJ. Abstract 3250: Caspase-1 from MDSC promote MyD88 dependent carcinogenesis that is T-cell independent Cancer Research. 76: 3250-3250. DOI: 10.1158/1538-7445.Am2016-3250  0.495
2015 Pardoll D. Cancer and the Immune System: Basic Concepts and Targets for Intervention Seminars in Oncology. 42: 523-538. PMID 26320058 DOI: 10.1053/J.Seminoncol.2015.05.003  0.475
2015 Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Buhu S, Slamon DJ, Wolchok JD, Pardoll DM, et al. Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses. Cell. 162: 974-86. PMID 26317466 DOI: 10.1016/J.Cell.2015.07.011  0.496
2015 Geis AL, Fan H, Wu X, Wu S, Huso DL, Wolfe JL, Sears CL, Pardoll DM, Housseau F. Regulatory T cell response to enterotoxigenic Bacteroides fragilis colonization triggers IL-17-dependent colon carcinogenesis. Cancer Discovery. PMID 26201900 DOI: 10.1158/2159-8290.Cd-15-0447  0.359
2015 Kim JE, Patel MA, Mangraviti A, Velarde E, Theodros D, Mathios D, Jackson CM, Tyler B, Ye X, Brem H, Pardoll D, Lim M. 143 The Combination of anti-TIM-3 and anti-PD-1 Checkpoint Inhibitors With Focused Radiation Resulted in a Synergistic Antitumor Immune Response in a Preclinical Glioma Model. Neurosurgery. 62: 212. PMID 26181989 DOI: 10.1227/01.Neu.0000467105.60300.04  0.316
2015 Mathios D, Park CK, Marcus WD, Alter S, Rhode PR, Jeng EK, Wong HC, Pardoll DM, Lim M. Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model. International Journal of Cancer. Journal International Du Cancer. PMID 26174883 DOI: 10.1002/Ijc.29686  0.438
2015 Lipson EJ, Sharfman WH, Chen S, McMiller TL, Pritchard TS, Salas JT, Sartorius-Mergenthaler S, Freed I, Ravi S, Wang H, Luber B, Sproul JD, Taube JM, Pardoll DM, Topalian SL. Safety and immunologic correlates of Melanoma GVAX, a GM-CSF secreting allogeneic melanoma cell vaccine administered in the adjuvant setting. Journal of Translational Medicine. 13: 214. PMID 26143264 DOI: 10.1186/S12967-015-0572-3  0.337
2015 Apetoh L, Smyth MJ, Drake CG, Abastado JP, Apte RN, Ayyoub M, Blay JY, Bonneville M, Butterfield LH, Caignard A, Castelli C, Cavallo F, Celis E, Chen L, Colombo MP, ... ... Pardoll DM, et al. Consensus nomenclature for CD8(+) T cell phenotypes in cancer. Oncoimmunology. 4: e998538. PMID 26137416 DOI: 10.1080/2162402X.2014.998538  0.379
2015 Barbi J, Pardoll DM, Pan F. Ubiquitin-dependent regulation of Foxp3 and Treg function. Immunological Reviews. 266: 27-45. PMID 26085205 DOI: 10.1111/Imr.12312  0.366
2015 Patel MA, Pardoll DM. Concepts of immunotherapy for glioma. Journal of Neuro-Oncology. 123: 323-30. PMID 26070552 DOI: 10.1007/S11060-015-1810-5  0.386
2015 Le DT, Uram JN, Wang H, Bartlett BR, Kemberling H, Eyring AD, Skora AD, Luber BS, Azad NS, Laheru D, Biedrzycki B, Donehower RC, Zaheer A, Fisher GA, Crocenzi TS, ... ... Pardoll DM, et al. PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. The New England Journal of Medicine. 372: 2509-20. PMID 26028255 DOI: 10.1200/Jco.2015.33.18_Suppl.Lba100  0.444
2015 Mascanfroni ID, Takenaka MC, Yeste A, Patel B, Wu Y, Kenison JE, Siddiqui S, Basso AS, Otterbein LE, Pardoll DM, Pan F, Priel A, Clish CB, Robson SC, Quintana FJ. Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α. Nature Medicine. 21: 638-46. PMID 26005855 DOI: 10.1038/Nm.3868  0.376
2015 Noonan KA, Huff CA, Davis J, Lemas MV, Fiorino S, Bitzan J, Ferguson A, Emerling A, Luznik L, Matsui W, Powell J, Fuchs E, Rosner GL, Epstein C, Rudraraju L, ... ... Pardoll D, et al. Adoptive transfer of activated marrow-infiltrating lymphocytes induces measurable antitumor immunity in the bone marrow in multiple myeloma. Science Translational Medicine. 7: 288ra78. PMID 25995224 DOI: 10.1126/Scitranslmed.Aaa7014  0.448
2015 Taube JM, Young GD, McMiller TL, Chen S, Salas JT, Pritchard TS, Xu H, Meeker AK, Fan J, Cheadle C, Berger AE, Pardoll DM, Topalian SL. Differential expression of immune-regulatory genes associated with PD-L1 display in melanoma: implications for PD-1 pathway blockade. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 25944800 DOI: 10.1158/1078-0432.Ccr-15-0244  0.319
2015 Pardoll DM. Distinct mechanisms of tumor resistance to NK killing: of mice and men. Immunity. 42: 605-6. PMID 25902479 DOI: 10.1016/J.Immuni.2015.04.007  0.364
2015 Fu J, Kanne DB, Leong M, Glickman LH, McWhirter SM, Lemmens E, Mechette K, Leong JJ, Lauer P, Liu W, Sivick KE, Zeng Q, Soares KC, Zheng L, Portnoy DA, ... ... Pardoll DM, et al. STING agonist formulated cancer vaccines can cure established tumors resistant to PD-1 blockade. Science Translational Medicine. 7: 283ra52. PMID 25877890 DOI: 10.1126/Scitranslmed.Aaa4306  0.481
2015 Llosa NJ, Cruise M, Tam A, Wicks EC, Hechenbleikner EM, Taube JM, Blosser RL, Fan H, Wang H, Luber BS, Zhang M, Papadopoulos N, Kinzler KW, Vogelstein B, Sears CL, ... ... Pardoll DM, et al. The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints. Cancer Discovery. 5: 43-51. PMID 25358689 DOI: 10.1158/2159-8290.Cd-14-0863  0.594
2015 Mathios D, Ruzevick J, Jackson CM, Xu H, Shah S, Taube JM, Burger PC, McCarthy EF, Quinones-Hinojosa A, Pardoll DM, Lim M. PD-1, PD-L1, PD-L2 expression in the chordoma microenvironment. Journal of Neuro-Oncology. 121: 251-9. PMID 25349132 DOI: 10.1007/S11060-014-1637-5  0.335
2015 Overacre AE, Kurtulus S, Sznol M, Pardoll DM, Anderson A, Vignali DAA. Combination immunotherapy: Where do we go from here? Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/S40425-015-0083-Z  0.371
2015 Zeng Q, Qualliotine J, Blosser R, Pardoll D, Kim Y. MDSCs enhance tumor cell proliferation in a caspase-1 related inflammasome cytokines dependent way Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P317  0.476
2015 Mathios D, Kim J, Phallen J, Mangraviti A, Park C, Theodros D, Jackson C, Garzon-Muvdi T, Kim E, Ye X, Tyler B, Brem H, Pardoll D, Lim M. Optimizing the delivery of chemotherapy in the setting of immunotherapy in a preclinical glioblastoma model Journal For Immunotherapy of Cancer. 3. DOI: 10.1186/2051-1426-3-S2-P307  0.328
2015 Llosa NJ, Cruise M, Tam A, Wick E, Hechenbleikner E, Taube J, Blosser L, Fan H, Wang H, Zhang M, Luber B, Papadopoulos N, Kinzler K, Vogelstein B, Sears C, ... ... Pardoll D, et al. Abstract 451: The vigorous immune microenvironment of microsatellite instable colon cancer is balanced by multiple counter-inhibitory checkpoints Cancer Research. 75: 451-451. DOI: 10.1158/1538-7445.Am2015-451  0.495
2015 Orberg ET, Fan H, Tam A, Wu S, Wu X, Ganguly S, Pardoll DM, Sears CL, Housseau F. 103 The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis European Journal of Cancer. 51. DOI: 10.1016/S0959-8049(16)30003-X  0.32
2014 Lipson EJ, Velculescu VE, Pritchard TS, Sausen M, Pardoll DM, Topalian SL, Diaz LA. Circulating tumor DNA analysis as a real-time method for monitoring tumor burden in melanoma patients undergoing treatment with immune checkpoint blockade. Journal For Immunotherapy of Cancer. 2: 42. PMID 25516806 DOI: 10.1186/S40425-014-0042-0  0.377
2014 Dejea CM, Wick EC, Hechenbleikner EM, White JR, Mark Welch JL, Rossetti BJ, Peterson SN, Snesrud EC, Borisy GG, Lazarev M, Stein E, Vadivelu J, Roslani AC, Malik AA, Wanyiri JW, ... ... Pardoll DM, et al. Microbiota organization is a distinct feature of proximal colorectal cancers. Proceedings of the National Academy of Sciences of the United States of America. 111: 18321-6. PMID 25489084 DOI: 10.1073/Pnas.1406199111  0.43
2014 Belcaid Z, Phallen JA, Zeng J, See AP, Mathios D, Gottschalk C, Nicholas S, Kellett M, Ruzevick J, Jackson C, Albesiano E, Durham NM, Ye X, Tran PT, Tyler B, ... ... Pardoll DM, et al. Focal radiation therapy combined with 4-1BB activation and CTLA-4 blockade yields long-term survival and a protective antigen-specific memory response in a murine glioma model. Plos One. 9: e101764. PMID 25013914 DOI: 10.1371/Journal.Pone.0101764  0.447
2014 Zheng L, Edil BH, Soares KC, El-Shami K, Uram JN, Judkins C, Zhang Z, Onners B, Laheru D, Pardoll D, Jaffee EM, Schulick RD. A safety and feasibility study of an allogeneic colon cancer cell vaccine administered with a granulocyte-macrophage colony stimulating factor-producing bystander cell line in patients with metastatic colorectal cancer. Annals of Surgical Oncology. 21: 3931-7. PMID 24943235 DOI: 10.1245/S10434-014-3844-X  0.392
2014 Fu J, Malm IJ, Kadayakkara DK, Levitsky H, Pardoll D, Kim YJ. Preclinical evidence that PD1 blockade cooperates with cancer vaccine TEGVAX to elicit regression of established tumors. Cancer Research. 74: 4042-52. PMID 24812273 DOI: 10.1158/0008-5472.Can-13-2685  0.461
2014 Pardoll D. Immunotherapy: It Takes a Village Science. 344: 149-149. PMID 24723594 DOI: 10.1126/Science.344.6180.149-A  0.461
2014 Barbi J, Pardoll D, Pan F. Treg functional stability and its responsiveness to the microenvironment. Immunological Reviews. 259: 115-39. PMID 24712463 DOI: 10.1111/Imr.12172  0.367
2014 Wick EC, Rabizadeh S, Albesiano E, Wu X, Wu S, Chan J, Rhee KJ, Ortega G, Huso DL, Pardoll D, Housseau F, Sears CL. Stat3 activation in murine colitis induced by enterotoxigenic Bacteroides fragilis. Inflammatory Bowel Diseases. 20: 821-34. PMID 24704822 DOI: 10.1097/Mib.0000000000000019  0.395
2014 Li H, Chiappinelli KB, Guzzetta AA, Easwaran H, Yen RW, Vatapalli R, Topper MJ, Luo J, Connolly RM, Azad NS, Stearns V, Pardoll DM, Davidson N, Jones PA, Slamon DJ, et al. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget. 5: 587-98. PMID 24583822 DOI: 10.18632/Oncotarget.1782  0.398
2014 Lipson EJ, Sharfman WH, Chen S, McMiller TL, Pritchard TS, Salas JT, Sartorius-Mergenthaler S, Ravi S, Wang H, Taube JM, Pardoll DM, Topalian SL. Safety and immunologic correlates of allogeneic melanoma GVAX (MelGVAX), a genetically engineered whole-cell melanoma vaccine. Journal of Clinical Oncology. 32. DOI: 10.1200/Jco.2014.32.15_Suppl.E20001  0.345
2014 Llosa NJ, Housseau F, Wick EC, Hechenbleikner L, Cruise M, Anders R, Sears C, Pardoll DM. Immune checkpoints expression in MSI versus MSS colorectal cancers and their potential therapeutic implications. Journal of Clinical Oncology. 32: 3620-3620. DOI: 10.1200/Jco.2014.32.15_Suppl.3620  0.306
2014 Fu J, Pardoll D, Kim YJ. Cyclic dinucleotides (CDNs) anti-tumors response by activating DC and NK cell crosstalk Journal For Immunotherapy of Cancer. 2. DOI: 10.1186/2051-1426-2-S3-P169  0.425
2014 Glickman LH, Kanne DB, McWhirter SM, Leong ML, Lemmens EE, Metchette K, Vance RE, Pardoll DM, Dubensky TW. Abstract 2566: Activation of tumor-initiated T cell priming and tumor destruction with potent STING-activating cyclic dinucleotide derivatives Cancer Research. 74: 2566-2566. DOI: 10.1158/1538-7445.Am2014-2566  0.462
2014 Mathios D, Phallen J, Park C, Jackson C, Nicholas S, Tyler B, Pardoll D, Brem H, Lim M. It-21Pd-1 Blockade Shows Synergistic Survival, Anti-Tumor Immune Response And Long-Term Memory With Interstitial But Not Systemic Chemotherapy: Study In A Murine Glioblastoma Model. Neuro-Oncology. 16. DOI: 10.1093/Neuonc/Nou258.19  0.327
2013 Wada S, Harris TJ, Tryggestad E, Yoshimura K, Zeng J, Yen HR, Getnet D, Grosso JF, Bruno TC, De Marzo AM, Netto GJ, Pardoll DM, DeWeese TL, Wong J, Drake CG. Combined treatment effects of radiation and immunotherapy: studies in an autochthonous prostate cancer model. International Journal of Radiation Oncology, Biology, Physics. 87: 769-76. PMID 24064321 DOI: 10.1016/J.Ijrobp.2013.07.015  0.636
2013 Chen Z, Barbi J, Bu S, Yang HY, Li Z, Gao Y, Jinasena D, Fu J, Lin F, Chen C, Zhang J, Yu N, Li X, Shan Z, Nie J, ... ... Pardoll DM, et al. The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3. Immunity. 39: 272-85. PMID 23973223 DOI: 10.1016/J.Immuni.2013.08.006  0.445
2013 Sharma MD, Huang L, Choi JH, Lee EJ, Wilson JM, Lemos H, Pan F, Blazar BR, Pardoll DM, Mellor AL, Shi H, Munn DH. An inherently bifunctional subset of Foxp3+ T helper cells is controlled by the transcription factor eos. Immunity. 38: 998-1012. PMID 23684987 DOI: 10.1016/J.Immuni.2013.01.013  0.429
2013 Wada S, Jackson CM, Yoshimura K, Yen HR, Getnet D, Harris TJ, Goldberg MV, Bruno TC, Grosso JF, Durham N, Netto GJ, Pardoll DM, Drake CG. Sequencing CTLA-4 blockade with cell-based immunotherapy for prostate cancer. Journal of Translational Medicine. 11: 89. PMID 23557194 DOI: 10.1186/1479-5876-11-89  0.779
2013 Zeng J, See AP, Phallen J, Jackson CM, Belcaid Z, Ruzevick J, Durham N, Meyer C, Harris TJ, Albesiano E, Pradilla G, Ford E, Wong J, Hammers HJ, Mathios D, ... ... Pardoll D, et al. Anti-PD-1 blockade and stereotactic radiation produce long-term survival in mice with intracranial gliomas. International Journal of Radiation Oncology, Biology, Physics. 86: 343-9. PMID 23462419 DOI: 10.1016/J.Ijrobp.2012.12.025  0.67
2013 Vasquez-Dunddel D, Pan F, Zeng Q, Gorbounov M, Albesiano E, Fu J, Blosser RL, Tam AJ, Bruno T, Zhang H, Pardoll D, Kim Y. STAT3 regulates arginase-I in myeloid-derived suppressor cells from cancer patients. The Journal of Clinical Investigation. 123: 1580-9. PMID 23454751 DOI: 10.1172/Jci60083  0.436
2013 Kang TH, Mao CP, Lee SY, Chen A, Lee JH, Kim TW, Alvarez RD, Roden RB, Pardoll D, Hung CF, Wu TC. Chemotherapy acts as an adjuvant to convert the tumor microenvironment into a highly permissive state for vaccination-induced antitumor immunity. Cancer Research. 73: 2493-504. PMID 23418322 DOI: 10.1158/0008-5472.CAN-12-4241  0.371
2013 Barbi J, Pardoll D, Pan F. Metabolic control of the Treg/Th17 axis. Immunological Reviews. 252: 52-77. PMID 23405895 DOI: 10.1111/Imr.12029  0.414
2013 Lyford-Pike S, Peng S, Young GD, Taube JM, Westra WH, Akpeng B, Bruno TC, Richmon JD, Wang H, Bishop JA, Chen L, Drake CG, Topalian SL, Pardoll DM, Pai SI. Evidence for a role of the PD-1:PD-L1 pathway in immune resistance of HPV-associated head and neck squamous cell carcinoma. Cancer Research. 73: 1733-41. PMID 23288508 DOI: 10.1158/0008-5472.Can-12-2384  0.559
2013 McAllister F, Bailey JM, Alsina J, Nirschl C, Roeser J, Blake D, Lankapali R, Sears C, Jaffee EM, Kolls J, Drake CG, Pardoll DM, Leach SD. TH17 cells and early pancreatic tumorigenesis. Journal of Clinical Oncology. 31: 144-144. DOI: 10.1200/Jco.2013.31.4_Suppl.144  0.372
2012 Pardoll DM. Immunology beats cancer: a blueprint for successful translation. Nature Immunology. 13: 1129-32. PMID 23160205 DOI: 10.1038/Ni.2392  0.321
2012 See AP, Han JE, Phallen J, Binder Z, Gallia G, Pan F, Jinasena D, Jackson C, Belcaid Z, Jeong SJ, Gottschalk C, Zeng J, Ruzevick J, Nicholas S, Kim Y, ... ... Pardoll DM, et al. The role of STAT3 activation in modulating the immune microenvironment of GBM. Journal of Neuro-Oncology. 110: 359-68. PMID 23096132 DOI: 10.1007/S11060-012-0981-6  0.386
2012 Olino K, Edil BH, Meckel KF, Pan X, Thuluvath A, Pardoll DM, Schulick RD, Yoshimura K, Weber WP. Glycolipid antigens for treating hepatic colorectal cancer metastases and their effect on the therapeutic efficacy of live attenuated Listeria monocytogenes. Archives of Surgery (Chicago, Ill. : 1960). 147: 480-2. PMID 22785644 DOI: 10.1001/archsurg.2011.2206  0.334
2012 Pan F, Barbi J, Pardoll DM. Hypoxia-inducible factor 1: A link between metabolism and T cell differentiation and a potential therapeutic target. Oncoimmunology. 1: 510-515. PMID 22754770 DOI: 10.4161/Onci.19457  0.409
2012 Bettini ML, Pan F, Bettini M, Finkelstein D, Rehg JE, Floess S, Bell BD, Ziegler SF, Huehn J, Pardoll DM, Vignali DA. Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity. 36: 717-30. PMID 22579476 DOI: 10.1016/J.Immuni.2012.03.020  0.382
2012 Pardoll D, Drake C. Immunotherapy earns its spot in the ranks of cancer therapy Journal of Experimental Medicine. 209: 201-209. PMID 22330682 DOI: 10.1084/Jem.20112275  0.393
2012 Topalian SL, Drake CG, Pardoll DM. Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity. Current Opinion in Immunology. 24: 207-12. PMID 22236695 DOI: 10.1016/J.Coi.2011.12.009  0.418
2012 Woo SR, Turnis ME, Goldberg MV, Bankoti J, Selby M, Nirschl CJ, Bettini ML, Gravano DM, Vogel P, Liu CL, Tangsombatvisit S, Grosso JF, Netto G, Smeltzer MP, Chaux A, ... ... Pardoll DM, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Research. 72: 917-27. PMID 22186141 DOI: 10.1158/0008-5472.Can-11-1620  0.808
2012 Olino K, Wada S, Edil BH, Pan X, Meckel K, Weber W, Slansky J, Tamada K, Lauer P, Brockstedt D, Pardoll D, Schulick R, Yoshimura K. Tumor-associated antigen expressing Listeria monocytogenes induces effective primary and memory T-cell responses against hepatic colorectal cancer metastases. Annals of Surgical Oncology. 19: S597-607. PMID 21979110 DOI: 10.1245/S10434-011-2037-0  0.304
2012 Bruno TC, Rothwell C, Grosso JF, Getnet D, Yen HR, Durham NM, Netto G, Pardoll DM, Drake CG. Anti-tumor effects of endogenous prostate cancer-specific CD8 T cells in a murine TCR transgenic model. The Prostate. 72: 514-22. PMID 21761425 DOI: 10.1002/Pros.21453  0.495
2011 Topalian SL, Weiner GJ, Pardoll DM. Cancer immunotherapy comes of age. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 4828-36. PMID 22042955 DOI: 10.1200/Jco.2011.38.0899  0.446
2011 Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, ... ... Pardoll DM, et al. Control of TH17/Treg balance by hypoxia-inducible factor 1 Cell. 146: 772-784. PMID 21871655 DOI: 10.1016/J.Cell.2011.07.033  0.405
2011 Davis MB, Vasquez-Dunddel D, Fu J, Albesiano E, Pardoll D, Kim YJ. Intratumoral administration of TLR4 agonist absorbed into a cellular vector improves antitumor responses. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 3984-92. PMID 21543518 DOI: 10.1158/1078-0432.Ccr-10-3262  0.481
2011 Lee H, Deng J, Xin H, Liu Y, Pardoll D, Yu H. A requirement of STAT3 DNA binding precludes Th-1 immunostimulatory gene expression by NF-κB in tumors. Cancer Research. 71: 3772-80. PMID 21502401 DOI: 10.1158/0008-5472.Can-10-3304  0.359
2011 Sears CL, Pardoll DM. Perspective: alpha-bugs, their microbial partners, and the link to colon cancer. The Journal of Infectious Diseases. 203: 306-11. PMID 21208921 DOI: 10.1093/Jinfdis/Jiq061  0.301
2010 Wang L, Yi T, Zhang W, Pardoll DM, Yu H. IL-17 enhances tumor development in carcinogen-induced skin cancer. Cancer Research. 70: 10112-20. PMID 21159633 DOI: 10.1158/0008-5472.Can-10-0775  0.376
2010 Le DT, Pardoll DM, Jaffee EM. Cellular vaccine approaches. Cancer Journal (Sudbury, Mass.). 16: 304-10. PMID 20693840 DOI: 10.1097/Ppo.0B013E3181Eb33D7  0.465
2010 Albesiano E, Davis M, See AP, Han JE, Lim M, Pardoll DM, Kim Y. Immunologic consequences of signal transducers and activators of transcription 3 activation in human squamous cell carcinoma. Cancer Research. 70: 6467-76. PMID 20682796 DOI: 10.1158/0008-5472.Can-09-4058  0.424
2010 Nguyen LT, Radhakrishnan S, Ciric B, Tamada K, Shin T, Pardoll DM, Chen L, Rodriguez M, Pease LR. Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells (The Journal of Experimental Medicine (November 18, 2002) 196, 10 (1393-1398)) Journal of Experimental Medicine. 207: 901. PMID 20368577 DOI: 10.1084/Jem.2002146632610R  0.343
2010 Getnet D, Grosso JF, Goldberg MV, Harris TJ, Yen HR, Bruno TC, Durham NM, Hipkiss EL, Pyle KJ, Wada S, Pan F, Pardoll DM, Drake CG. A role for the transcription factor Helios in human CD4(+)CD25(+) regulatory T cells. Molecular Immunology. 47: 1595-600. PMID 20226531 DOI: 10.1016/J.Molimm.2010.02.001  0.81
2010 Ishiwata K, Watanabe N, Guo M, Tomihara K, Brumlik MJ, Yagita H, Pardoll D, Chen L, Shin T. Costimulator B7-DC attenuates strong Th2 responses induced by Nippostrongylus brasiliensis. Journal of Immunology (Baltimore, Md. : 1950). 184: 2086-94. PMID 20065112 DOI: 10.4049/Jimmunol.0804051  0.355
2009 Brahmer JR, Topalian SL, Powderly J, Wollner I, Picus J, Drake CG, Stankevich E, Korman A, Pardoll D, Lowy I. Phase II experience with MDX-1106 (Ono-4538), an anti-PD-1 monoclonal antibody, in patients with selected refractory or relapsed malignancies. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 3018. PMID 27962055 DOI: 10.1200/Jco.2009.27.15_Suppl.3018  0.331
2009 Yen HR, Harris TJ, Wada S, Grosso JF, Getnet D, Goldberg MV, Liang KL, Bruno TC, Pyle KJ, Chan SL, Anders RA, Trimble CL, Adler AJ, Lin TY, Pardoll DM, et al. Tc17 CD8 T cells: functional plasticity and subset diversity. Journal of Immunology (Baltimore, Md. : 1950). 183: 7161-8. PMID 19917680 DOI: 10.4049/Jimmunol.0900368  0.803
2009 Kortylewski M, Swiderski P, Herrmann A, Wang L, Kowolik C, Kujawski M, Lee H, Scuto A, Liu Y, Yang C, Deng J, Soifer HS, Raubitschek A, Forman S, Rossi JJ, ... Pardoll DM, et al. In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses. Nature Biotechnology. 27: 925-32. PMID 19749770 DOI: 10.1038/Nbt.1564  0.43
2009 Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, Huso DL, Brancati FL, Wick E, McAllister F, Housseau F, Pardoll DM, Sears CL. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nature Medicine. 15: 1016-22. PMID 19701202 DOI: 10.1038/Nm.2015  0.322
2009 Pan F, Yu H, Dang EV, Barbi J, Pan X, Grosso JF, Jinasena D, Sharma SM, McCadden EM, Getnet D, Drake CG, Liu JO, Ostrowski MC, Pardoll DM. Eos mediates Foxp3-dependent gene silencing in CD4+ regulatory T cells. Science (New York, N.Y.). 325: 1142-6. PMID 19696312 DOI: 10.1126/Science.1176077  0.409
2009 Pletneva M, Fan H, Park JJ, Radojcic V, Jie C, Yu Y, Chan C, Redwood A, Pardoll D, Housseau F. IFN-producing killer dendritic cells are antigen-presenting cells endowed with T-cell cross-priming capacity. Cancer Research. 69: 6607-14. PMID 19679552 DOI: 10.1158/0008-5472.Can-09-0508  0.793
2009 Pardoll D. Metastasis-Promoting Immunity: When T Cells Turn to the Dark Side Cancer Cell. 16: 81-82. PMID 19647215 DOI: 10.1016/J.Ccr.2009.07.007  0.479
2009 Grosso JF, Goldberg MV, Getnet D, Bruno TC, Yen HR, Pyle KJ, Hipkiss E, Vignali DA, Pardoll DM, Drake CG. Functionally distinct LAG-3 and PD-1 subsets on activated and chronically stimulated CD8 T cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 6659-69. PMID 19454660 DOI: 10.4049/Jimmunol.0804211  0.802
2009 Wada S, Yoshimura K, Hipkiss EL, Harris TJ, Yen HR, Goldberg MV, Grosso JF, Getnet D, Demarzo AM, Netto GJ, Anders R, Pardoll DM, Drake CG. Cyclophosphamide augments antitumor immunity: studies in an autochthonous prostate cancer model. Cancer Research. 69: 4309-18. PMID 19435909 DOI: 10.1158/0008-5472.Can-08-4102  0.822
2009 Lee H, Herrmann A, Deng JH, Kujawski M, Niu G, Li Z, Forman S, Jove R, Pardoll DM, Yu H. Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell. 15: 283-93. PMID 19345327 DOI: 10.1016/J.Ccr.2009.02.015  0.305
2009 Getnet D, Maris CH, Hipkiss EL, Grosso JF, Harris TJ, Yen HR, Bruno TC, Wada S, Adler A, Georgantas RW, Jie C, Goldberg MV, Pardoll DM, Drake CG. Tumor recognition and self-recognition induce distinct transcriptional profiles in antigen-specific CD4 T cells. Journal of Immunology (Baltimore, Md. : 1950). 182: 4675-85. PMID 19342643 DOI: 10.4049/Jimmunol.0803400  0.829
2009 Workman CJ, Wang Y, El Kasmi KC, Pardoll DM, Murray PJ, Drake CG, Vignali DA. LAG-3 regulates plasmacytoid dendritic cell homeostasis. Journal of Immunology (Baltimore, Md. : 1950). 182: 1885-91. PMID 19201841 DOI: 10.4049/Jimmunol.0800185  0.461
2009 Kortylewski M, Xin H, Kujawski M, Lee H, Liu Y, Harris T, Drake C, Pardoll D, Yu H. Regulation of the IL-23 and IL-12 balance by Stat3 signaling in the tumor microenvironment. Cancer Cell. 15: 114-23. PMID 19185846 DOI: 10.1016/J.Ccr.2008.12.018  0.679
2009 Wang T, Jiang Q, Chan C, Gorski KS, McCadden E, Kardian D, Pardoll D, Whartenby KA. Inhibition of activation-induced death of dendritic cells and enhancement of vaccine efficacy via blockade of MINOR. Blood. 113: 2906-13. PMID 19164597 DOI: 10.1182/Blood-2008-08-176354  0.742
2009 Trimble CL, Peng S, Kos F, Gravitt P, Viscidi R, Sugar E, Pardoll D, Wu TC. A phase I trial of a human papillomavirus DNA vaccine for HPV16+ cervical intraepithelial neoplasia 2/3. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 361-7. PMID 19118066 DOI: 10.1158/1078-0432.Ccr-08-1725  0.3
2009 Wolfe JL, Wu S, Wu X, Rhee K, Huso DL, Housseau F, Pardoll DM, Sears CL. M1997 CD4+ Lymphocytes Regulate Colonic Tumor Formation in MIN Mice Colonized with Enterotoxigenic Bacteroides Fragilis (ETBF) Gastroenterology. 136. DOI: 10.1016/S0016-5085(09)62131-4  0.353
2008 Brahmer JR, Topalian S, Wollner I, Powderly JD, Picus J, Drake C, Covino J, Korman A, Pardoll D, Lowy I. Safety and activity of MDX-1106 (ONO-4538), an anti-PD-1 monoclonal antibody, in patients with selected refractory or relapsed malignancies. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 26: 3006. PMID 27947615 DOI: 10.1200/Jco.2008.26.15_Suppl.3006  0.326
2008 Rutebemberwa A, Ray SC, Astemborski J, Levine J, Liu L, Dowd KA, Clute S, Wang C, Korman A, Sette A, Sidney J, Pardoll DM, Cox AL. High-programmed death-1 levels on hepatitis C virus-specific T cells during acute infection are associated with viral persistence and require preservation of cognate antigen during chronic infection. Journal of Immunology (Baltimore, Md. : 1950). 181: 8215-25. PMID 19050238 DOI: 10.4049/Jimmunol.181.12.8215  0.322
2008 Harris TJ, Hipkiss EL, Borzillary S, Wada S, Grosso JF, Yen HR, Getnet D, Bruno TC, Goldberg MV, Pardoll DM, DeWeese TL, Drake CG. Radiotherapy augments the immune response to prostate cancer in a time-dependent manner. The Prostate. 68: 1319-29. PMID 18561247 DOI: 10.1002/Pros.20794  0.817
2008 Matsumoto K, Fukuyama S, Eguchi-Tsuda M, Nakano T, Matsumoto T, Matsumura M, Moriwaki A, Kan-o K, Wada Y, Yagita H, Shin T, Pardoll DM, Patcharee R, Azuma M, Nakanishi Y, et al. B7-DC induced by IL-13 works as a feedback regulator in the effector phase of allergic asthma. Biochemical and Biophysical Research Communications. 365: 170-5. PMID 17981145 DOI: 10.1016/J.Bbrc.2007.10.156  0.332
2008 Wu S, Wu X, Rhee K, Housseau F, Pardoll D, Huso D, Danaher S, Sears C. Enterotoxigenic Bacteroides fragilis colitis is regulated, in part, by CD4+ T lymphocytes: P-103. Inflammatory Bowel Diseases. 14. DOI: 10.1097/00054725-200801001-00136  0.373
2007 Pardoll DM. Building the bionic T cell. Nature Medicine. 13: 1411-3. PMID 18064030 DOI: 10.1038/Nm1207-1411  0.46
2007 Pentcheva-Hoang T, Chen L, Pardoll DM, Allison JP. Programmed death-1 concentration at the immunological synapse is determined by ligand affinity and availability. Proceedings of the National Academy of Sciences of the United States of America. 104: 17765-70. PMID 17968013 DOI: 10.1073/Pnas.0708767104  0.314
2007 Yoshimura K, Laird LS, Chia CY, Meckel KF, Slansky JE, Thompson JM, Jain A, Pardoll DM, Schulick RD. Live attenuated Listeria monocytogenes effectively treats hepatic colorectal cancer metastases and is strongly enhanced by depletion of regulatory T cells. Cancer Research. 67: 10058-66. PMID 17942940 DOI: 10.1158/0008-5472.Can-07-0573  0.475
2007 Grosso JF, Kelleher CC, Harris TJ, Maris CH, Hipkiss EL, De Marzo A, Anders R, Netto G, Getnet D, Bruno TC, Goldberg MV, Pardoll DM, Drake CG. LAG-3 regulates CD8+ T cell accumulation and effector function in murine self- and tumor-tolerance systems. The Journal of Clinical Investigation. 117: 3383-92. PMID 17932562 DOI: 10.1172/Jci31184  0.835
2007 Harris TJ, Grosso JF, Yen HR, Xin H, Kortylewski M, Albesiano E, Hipkiss EL, Getnet D, Goldberg MV, Maris CH, Housseau F, Yu H, Pardoll DM, Drake CG. Cutting edge: An in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity. Journal of Immunology (Baltimore, Md. : 1950). 179: 4313-7. PMID 17878325 DOI: 10.4049/Jimmunol.179.7.4313  0.805
2007 Peng S, Trimble C, Wu L, Pardoll D, Roden R, Hung CF, Wu TC. HLA-DQB1*02–Restricted HPV-16 E7 Peptide–Specific CD4+ T-Cell Immune Responses Correlate with Regression of HPV-16–Associated High-Grade Squamous Intraepithelial Lesions Clinical Cancer Research. 13: 2479-2487. PMID 17438108 DOI: 10.1158/1078-0432.Ccr-06-2916  0.326
2007 Goldberg MV, Maris CH, Hipkiss EL, Flies AS, Zhen L, Tuder RM, Grosso JF, Harris TJ, Getnet D, Whartenby KA, Brockstedt DG, Dubensky TW, Chen L, Pardoll DM, Drake CG. Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood. 110: 186-92. PMID 17392506 DOI: 10.1182/Blood-2006-12-062422  0.811
2007 Lin KY, Lu D, Hung CF, Peng S, Huang L, Jie C, Murillo F, Rowley J, Tsai YC, He L, Kim DJ, Jaffee E, Pardoll D, Wu TC. Ectopic expression of vascular cell adhesion molecule-1 as a new mechanism for tumor immune evasion. Cancer Research. 67: 1832-41. PMID 17308126 DOI: 10.1158/0008-5472.Can-06-3014  0.762
2007 Tsushima F, Yao S, Shin T, Flies A, Flies S, Xu H, Tamada K, Pardoll DM, Chen L. Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood. 110: 180-5. PMID 17289811 DOI: 10.1182/Blood-2006-11-060087  0.404
2007 Melero I, Hervas-Stubbs S, Glennie M, Pardoll DM, Chen L. Immunostimulatory monoclonal antibodies for cancer therapy. Nature Reviews. Cancer. 7: 95-106. PMID 17251916 DOI: 10.1038/Nrc2051  0.347
2007 Pan F, Sun L, Kardian DB, Whartenby KA, Pardoll DM, Liu JO. Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. Nature. 445: 433-6. PMID 17230191 DOI: 10.1038/Nature05476  0.321
2006 Ravi R, Fuchs EJ, Jain A, Pham V, Yoshimura K, Prouser T, Jalla S, Zhou X, Garrett-Mayer E, Kaufmann SH, Schulick RD, Pardoll DM, Bedi A. Resistance of cancers to immunologic cytotoxicity and adoptive immunotherapy via X-linked inhibitor of apoptosis protein expression and coexisting defects in mitochondrial death signaling. Cancer Research. 66: 1730-9. PMID 16452233 DOI: 10.1158/0008-5472.Can-05-3377  0.303
2006 Chan CW, Crafton E, Fan HN, Flook J, Yoshimura K, Skarica M, Brockstedt D, Dubensky TW, Stins MF, Lanier LL, Pardoll DM, Housseau F. Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity. Nature Medicine. 12: 207-13. PMID 16444266 DOI: 10.1038/Nm1352  0.412
2006 Yoshimura K, Jain A, Allen HE, Laird LS, Chia CY, Ravi S, Brockstedt DG, Giedlin MA, Bahjat KS, Leong ML, Slansky JE, Cook DN, Dubensky TW, Pardoll DM, Schulick RD. Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes. Cancer Research. 66: 1096-104. PMID 16424046 DOI: 10.1158/0008-5472.Can-05-2307  0.464
2005 Kortylewski M, Kujawski M, Wang T, Wei S, Zhang S, Pilon-Thomas S, Niu G, Kay H, Mulé J, Kerr WG, Jove R, Pardoll D, Yu H. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nature Medicine. 11: 1314-21. PMID 16288283 DOI: 10.1038/Nm1325  0.454
2005 Laheru DA, Pardoll DM, Jaffee EM. Genes to vaccines for immunotherapy: how the molecular biology revolution has influenced cancer immunology. Molecular Cancer Therapeutics. 4: 1645-52. PMID 16275985 DOI: 10.1158/1535-7163.Mct-05-0151  0.434
2005 Whartenby KA, Calabresi PA, McCadden E, Nguyen B, Kardian D, Wang T, Mosse C, Pardoll DM, Small D. Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 16741-6. PMID 16272221 DOI: 10.1073/Pnas.0506088102  0.434
2005 Niu G, Wright KL, Ma Y, Wright GM, Huang M, Irby R, Briggs J, Karras J, Cress WD, Pardoll D, Jove R, Chen J, Yu H. Role of Stat3 in regulating p53 expression and function. Molecular and Cellular Biology. 25: 7432-40. PMID 16107692 DOI: 10.1128/Mcb.25.17.7432-7440.2005  0.324
2005 Cox AL, Mosbruger T, Lauer GM, Pardoll D, Thomas DL, Ray SC. Comprehensive analyses of CD8+ T cell responses during longitudinal study of acute human hepatitis C. Hepatology (Baltimore, Md.). 42: 104-12. PMID 15962289 DOI: 10.1002/Hep.20749  0.327
2005 Kim J, Myers AC, Chen L, Pardoll DM, Truong-Tran QA, Lane AP, McDyer JF, Fortuno L, Schleimer RP. Constitutive and inducible expression of b7 family of ligands by human airway epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 33: 280-9. PMID 15961727 DOI: 10.1165/Rcmb.2004-0129Oc  0.355
2005 Cox AL, Mosbruger T, Mao Q, Liu Z, Wang XH, Yang HC, Sidney J, Sette A, Pardoll D, Thomas DL, Ray SC. Cellular immune selection with hepatitis C virus persistence in humans. The Journal of Experimental Medicine. 201: 1741-52. PMID 15939790 DOI: 10.1084/Jem.20050121  0.383
2005 Shin T, Yoshimura K, Shin T, Crafton EB, Tsuchiya H, Housseau F, Koseki H, Schulick RD, Chen L, Pardoll DM. In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. The Journal of Experimental Medicine. 201: 1531-41. PMID 15897272 DOI: 10.1084/Jem.20050072  0.449
2005 Burdelya L, Kujawski M, Niu G, Zhong B, Wang T, Zhang S, Kortylewski M, Shain K, Kay H, Djeu J, Dalton W, Pardoll D, Wei S, Yu H. Stat3 activity in melanoma cells affects migration of immune effector cells and nitric oxide-mediated antitumor effects. Journal of Immunology (Baltimore, Md. : 1950). 174: 3925-31. PMID 15778348 DOI: 10.4049/Jimmunol.174.7.3925  0.451
2005 Drake CG, Doody AD, Mihalyo MA, Huang CT, Kelleher E, Ravi S, Hipkiss EL, Flies DB, Kennedy EP, Long M, McGary PW, Coryell L, Nelson WG, Pardoll DM, Adler AJ. Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen. Cancer Cell. 7: 239-49. PMID 15766662 DOI: 10.1016/j.ccr.2005.01.027  0.597
2005 Zhou X, Jun DY, Thomas AM, Huang X, Huang LQ, Mautner J, Mo W, Robbins PF, Pardoll DM, Jaffee EM. Diverse CD8+ T-cell responses to renal cell carcinoma antigens in patients treated with an autologous granulocyte-macrophage colony-stimulating factor gene-transduced renal tumor cell vaccine. Cancer Research. 65: 1079-88. PMID 15705910  0.404
2005 Mautner J, Jaffee EM, Pardoll DM. Tumor-specific CD4+ T cells from a patient with renal cell carcinoma recognize diverse shared antigens. International Journal of Cancer. 115: 752-9. PMID 15704175 DOI: 10.1002/Ijc.20927  0.515
2005 Brockstedt DG, Hampl J, Bahjat K, Lutz E, Leong M, Liu W, Pardoll D, Giedlin M, Jaffee E, Dubensky T. Characterization of Mesothelin-Specific T Cell Responses in Healthy Individuals Journal of Immunotherapy. 28: 631. DOI: 10.1097/01.Cji.0000191007.62728.66  0.397
2005 Aalamian-Mattheis M, Wang J, Jalla S, Hipkiss E, Flies D, Harris T, Drake CG, Pardoll DM, Fuchs EJ. 245: Regression of Prostate Cancer in Animals Treated with Donor Lymphocyte Infusion (DLI) and a Cell Based Tumor Vaccine after Conditioning with a Single Dose of Cyclophosphamide Journal of Urology. 173: 67-67. DOI: 10.1016/S0022-5347(18)34510-5  0.694
2004 Ravi R, Jain AJ, Schulick RD, Pham V, Prouser TS, Allen H, Mayer EG, Yu H, Pardoll DM, Ashkenazi A, Bedi A. Elimination of hepatic metastases of colon cancer cells via p53-independent cross-talk between irinotecan and Apo2 ligand/TRAIL. Cancer Research. 64: 9105-14. PMID 15604280 DOI: 10.1158/0008-5472.Can-04-2488  0.337
2004 Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, Hipkiss EL, Ravi S, Kowalski J, Levitsky HI, Powell JD, Pardoll DM, Drake CG, Vignali DA. Role of LAG-3 in regulatory T cells. Immunity. 21: 503-13. PMID 15485628 DOI: 10.1016/J.Immuni.2004.08.010  0.778
2004 Yang Y, Huang CT, Huang X, Pardoll DM. Persistent Toll-like receptor signals are required for reversal of regulatory T cell-mediated CD8 tolerance. Nature Immunology. 5: 508-15. PMID 15064759 DOI: 10.1038/Ni1059  0.713
2004 Matsumoto K, Inoue H, Nakano T, Tsuda M, Yoshiura Y, Fukuyama S, Tsushima F, Hoshino T, Aizawa H, Akiba H, Pardoll D, Hara N, Yagita H, Azuma M, Nakanishi Y. B7-DC regulates asthmatic response by an IFN-gamma-dependent mechanism. Journal of Immunology (Baltimore, Md. : 1950). 172: 2530-41. PMID 14764726 DOI: 10.4049/Jimmunol.172.4.2530  0.389
2004 Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, Bhattacharya R, Gabrilovich D, Heller R, Coppola D, Dalton W, Jove R, Pardoll D, Yu H. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nature Medicine. 10: 48-54. PMID 14702634 DOI: 10.1038/Nm976  0.351
2004 Trimble C, Lin CT, Hung CF, Pai S, Juang J, He L, Gillison M, Pardoll D, Wu L, Wu TC. Comparison of the CD8+ T cell responses and antitumor effects generated by DNA vaccine administered through gene gun, biojector, and syringe. Vaccine. 21: 4036-42. PMID 12922140 DOI: 10.1016/S0264-410X(03)00275-5  0.619
2004 Pardoll D, Allison J. Translation of cancer immunotherapies Nature Medicine. 10: 1155-1155. DOI: 10.1038/Nm1104-1155A  0.367
2004 Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, Bhattacharya R, Gabrilovich D, Heller R, Coppola D, Dalton W, Jove R, Pardoll D, Yu H. Erratum: Corrigendum: Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells Nature Medicine. 10: 209-209. DOI: 10.1038/Nm0204-209B  0.334
2003 Gorski KS, Shin T, Crafton E, Otsuji M, Rattis FM, Huang X, Kelleher E, Francisco L, Pardoll D, Tsuchiya H. A set of genes selectively expressed in murine dendritic cells: utility of related cis-acting sequences for lentiviral gene transfer. Molecular Immunology. 40: 35-47. PMID 12909129 DOI: 10.1016/S0161-5890(03)00085-3  0.795
2003 Jain A, Slansky JE, Matey LC, Allen HE, Pardoll DM, Schulick RD. Synergistic effect of a granulocyte-macrophage colony-stimulating factor-transduced tumor vaccine and systemic interleukin-2 in the treatment of murine colorectal cancer hepatic metastases. Annals of Surgical Oncology. 10: 810-20. PMID 12900373 DOI: 10.1245/Aso.2003.10.006  0.378
2003 Youngnak P, Kozono Y, Kozono H, Iwai H, Otsuki N, Jin H, Omura K, Yagita H, Pardoll DM, Chen L, Azuma M. Differential binding properties of B7-H1 and B7-DC to programmed death-1. Biochemical and Biophysical Research Communications. 307: 672-7. PMID 12893276 DOI: 10.1016/S0006-291X(03)01257-9  0.314
2003 Zhou X, Cui Y, Huang X, Yu Z, Thomas AM, Ye Z, Pardoll DM, Jaffee EM, Cheng L. Lentivirus-mediated gene transfer and expression in established human tumor antigen-specific cytotoxic T cells and primary unstimulated T cells. Human Gene Therapy. 14: 1089-105. PMID 12885348 DOI: 10.1089/104303403322124800  0.344
2003 Shin T, Kennedy G, Gorski K, Tsuchiya H, Koseki H, Azuma M, Yagita H, Chen L, Powell J, Pardoll D, Housseau F. Cooperative B7-1/2 (CD80/CD86) and B7-DC costimulation of CD4+ T cells independent of the PD-1 receptor. The Journal of Experimental Medicine. 198: 31-8. PMID 12847135 DOI: 10.1084/Jem.20030242  0.755
2003 Cui Y, Kelleher E, Straley E, Fuchs E, Gorski K, Levitsky H, Borrello I, Civin CI, Schoenberger SP, Cheng L, Pardoll DM, Whartenby KA. Immunotherapy of established tumors using bone marrow transplantation with antigen gene--modified hematopoietic stem cells. Nature Medicine. 9: 952-8. PMID 12778137 DOI: 10.1038/Nm882  0.818
2003 Huang CT, Huso DL, Lu Z, Wang T, Zhou G, Kennedy EP, Drake CG, Morgan DJ, Sherman LA, Higgins AD, Pardoll DM, Adler AJ. CD4+ T cells pass through an effector phase during the process of in vivo tolerance induction. Journal of Immunology (Baltimore, Md. : 1950). 170: 3945-53. PMID 12682221 DOI: 10.4049/Jimmunol.170.8.3945  0.684
2003 Pardoll D. Does the Immune System See Tumors as Foreign or Self Annual Review of Immunology. 21: 807-839. PMID 12615893 DOI: 10.1146/Annurev.Immunol.21.120601.141135  0.419
2003 Radhakrishnan S, Nguyen LT, Ciric B, Ure DR, Zhou B, Tamada K, Dong H, Tseng SY, Shin T, Pardoll DM, Chen L, Kyle RA, Rodriguez M, Pease LR. Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 170: 1830-8. PMID 12574348  0.804
2003 Luznik L, Slansky JE, Jalla S, Borrello I, Levitsky HI, Pardoll DM, Fuchs EJ. Successful therapy of metastatic cancer using tumor vaccines in mixed allogeneic bone marrow chimeras. Blood. 101: 1645-52. PMID 12406877 DOI: 10.1182/Blood-2002-07-2233  0.667
2002 Pardoll D. T cells take aim at cancer Proceedings of the National Academy of Sciences of the United States of America. 99: 15840-15842. PMID 12461164 DOI: 10.1073/Pnas.262669499  0.506
2002 Pardoll DM. Tumor reactive T cells get a boost. Nature Biotechnology. 20: 1207-8. PMID 12454671 DOI: 10.1038/Nbt1202-1207  0.449
2002 Nguyen LT, Radhakrishnan S, Ciric B, Tamada K, Shin T, Pardoll DM, Chen L, Rodriguez M, Pease LR. Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells. The Journal of Experimental Medicine. 196: 1393-8. PMID 12438431 DOI: 10.1084/Jem.20021466  0.408
2002 Yamazaki T, Akiba H, Iwai H, Matsuda H, Aoki M, Tanno Y, Shin T, Tsuchiya H, Pardoll DM, Okumura K, Azuma M, Yagita H. Expression of Programmed Death 1 Ligands by Murine T Cells and APC Journal of Immunology. 169: 5538-5545. PMID 12421930 DOI: 10.4049/Jimmunol.169.10.5538  0.432
2002 Whartenby KA, Straley EE, Kim H, Racke F, Tanavde V, Gorski KS, Cheng L, Pardoll DM, Civin CI. Transduction of donor hematopoietic stem-progenitor cells with Fas ligand enhanced short-term engraftment in a murine model of allogeneic bone marrow transplantation. Blood. 100: 3147-54. PMID 12384412 DOI: 10.1182/Blood-2002-01-0118  0.745
2002 Wang XY, Li Y, Manjili MH, Repasky EA, Pardoll DM, Subjeck JR. Hsp110 over-expression increases the immunogenicity of the murine CT26 colon tumor. Cancer Immunology, Immunotherapy : Cii. 51: 311-9. PMID 12111119 DOI: 10.1007/S00262-002-0287-1  0.429
2002 Pardoll DM. Spinning molecular immunology into successful immunotherapy. Nature Reviews Immunology. 2: 227-238. PMID 12001994 DOI: 10.1038/Nri774  0.367
2002 Wilcox RA, Chapoval AI, Gorski KS, Otsuji M, Shin T, Flies DB, Tamada K, Mittler RS, Tsuchiya H, Pardoll DM, Chen L. Cutting edge: Expression of functional CD137 receptor by dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 168: 4262-7. PMID 11970964 DOI: 10.4049/Jimmunol.168.9.4262  0.76
2002 Housseau F, Langer DA, Oberholtzer SD, Moorthy A, Levitsky HI, Pardoll DM, Topalian SL. Tumor-specific CD8+ T lymphocytes derived from the peripheral blood of prostate cancer patients by in vitro stimulation with autologous tumor cell lines. International Journal of Cancer. Journal International Du Cancer. 98: 57-62. PMID 11857386 DOI: 10.1002/Ijc.10154  0.695
2001 Pardoll DM. Immunology. Stress, NK receptors, and immune surveillance. Science. 294: 534-536. PMID 11567108 DOI: 10.1126/Science.1066284  0.428
2001 O'Herrin SM, Slansky JE, Tang Q, Markiewicz MA, Gajewski TF, Pardoll DM, Schneck JP, Bluestone JA. Antigen-specific blockade of T cells in vivo using dimeric MHC peptide Journal of Immunology. 167: 2555-2560. PMID 11509595 DOI: 10.4049/Jimmunol.167.5.2555  0.442
2001 Golgher D, Korangy F, Gao B, Gorski K, Jaffee E, Edidin M, Pardoll DM, Elliott T. An immunodominant MHC class II-restricted tumor antigen is conformation dependent and binds to the endoplasmic reticulum chaperone, calreticulin Journal of Immunology. 167: 147-155. PMID 11418643 DOI: 10.4049/Jimmunol.167.1.147  0.758
2001 Hamad ARA, Srikrishnan A, Mirmonsef P, Broeren CPM, June CH, Pardoll D, Schneck JP. Lack of coreceptor allows survival of chronically stimulated double-negative α/β T cells: Implications for autoimmunity Journal of Experimental Medicine. 193: 1113-1121. PMID 11369783 DOI: 10.1084/Jem.193.10.1113  0.441
2001 Tseng SY, Otsuji M, Gorski K, Huang X, Slansky JE, Pai SI, Shalabi A, Shin T, Pardoll DM, Tsuchiya H. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. The Journal of Experimental Medicine. 193: 839-46. PMID 11283156 DOI: 10.1084/Jem.193.7.839  0.813
2000 Slansky JE, Rattis FM, Boyd LF, Fahmy T, Jaffee EM, Schneck JP, Margulies DH, Pardoll DM. Enhanced antigen-specific antitumor immunity with altered peptide ligands that stabilize the MHC-peptide-TCR complex Immunity. 13: 529-538. PMID 11070171 DOI: 10.1016/S1074-7613(00)00052-2  0.449
2000 Chen CH, Suh KW, Ji H, Choti MA, Pardoll DM, Wu TC. Antigen-specific immunotherapy for human papillomavirus 16 E7-expressing tumors grown in the liver Journal of Hepatology. 33: 91-98. PMID 10905591 DOI: 10.1016/S0168-8278(00)80164-6  0.416
2000 Wang TL, Ling M, Shih IM, Pham T, Pai SI, Lu Z, Kurman RJ, Pardoll DM, Wu TC. Intramuscular administration of E7-transfected dendritic cells generates the most potent E7-specific anti-tumor immunity. Gene Therapy. 7: 726-33. PMID 10822298 DOI: 10.1038/sj.gt.3301160  0.824
2000 Pardoll DM. Therapeutic Vaccination for Cancer Clinical Immunology. 95. PMID 10729237 DOI: 10.1006/Clim.1999.4819  0.315
2000 DiMeco F, Rhines LD, Hanes J, Tyler BM, Brat D, Torchiana E, Guarnieri M, Colombo MP, Pardoll DM, Finocchiaro G, Brem H, Olivi A. Paracrine delivery of IL-12 against intracranial 9L gliosarcoma in rats. Journal of Neurosurgery. 92: 419-27. PMID 10701528 DOI: 10.3171/Jns.2000.92.3.0419  0.307
2000 Lu Z, Yuan L, Zhou X, Sotomayor E, Levitsky HI, Pardoll DM. CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytes. The Journal of Experimental Medicine. 191: 541-50. PMID 10662799 DOI: 10.1084/Jem.191.3.541  0.808
2000 Adler AJ, Huang CT, Yochum GS, Marsh DW, Pardoll DM. In vivo CD4+ T cell tolerance induction versus priming is independent of the rate and number of cell divisions. Journal of Immunology (Baltimore, Md. : 1950). 164: 649-55. PMID 10623806 DOI: 10.4049/Jimmunol.164.2.649  0.688
1999 Suh KW, Piantadosi S, Yazdi HA, Pardoll DM, Brem H, Choti MA. Treatment of liver metastases from colon carcinoma with autologous tumor vaccine expressing granulocyte-macrophage colony-stimulating factor Journal of Surgical Oncology. 72: 218-224. PMID 10589037 DOI: 10.1002/(Sici)1096-9098(199912)72:4<218::Aid-Jso7>3.0.Co;2-N  0.403
1999 Ji H, Wang TL, Chen CH, Pai SI, Hung CF, Lin KY, Kurman RJ, Pardoll DM, Wu TC. Targeting human papillomavirus type 16 E7 to the endosomal/lysosomal compartment enhances the antitumor immunity of DNA vaccines against murine human papillomavirus type 16 E7-expressing tumors. Human Gene Therapy. 10: 2727-40. PMID 10584920 DOI: 10.1089/10430349950016474  0.786
1999 Pardoll DM. Inducing autoimmune disease to treat cancer Proceedings of the National Academy of Sciences of the United States of America. 96: 5340-5342. PMID 10318881 DOI: 10.1073/Pnas.96.10.5340  0.462
1998 Hamad AR, O'Herrin SM, Lebowitz MS, Srikrishnan A, Bieler J, Schneck J, Pardoll D. Potent T cell activation with dimeric peptide-major histocompatibility complex class II ligand: the role of CD4 coreceptor. The Journal of Experimental Medicine. 188: 1633-40. PMID 9802975 DOI: 10.1084/Jem.188.9.1633  0.429
1998 Pardoll DM, Topalian SL. The role of CD4+ T cell responses in antitumor immunity Current Opinion in Immunology. 10: 588-594. PMID 9794842 DOI: 10.1016/S0952-7915(98)80228-8  0.532
1998 Jaffee EM, Abrams R, Cameron J, Donehower R, Duerr M, Gossett J, Greten TF, Grochow L, Hruban R, Kern S, Lillemoe KD, O'Reilly S, Pardoll D, Pitt HA, Sauter P, et al. A Phase I Clinical Trial of Lethally Irradiated Allogeneic Pancreatic Tumor Cells Transfected with the GM-CSF Gene for the Treatment of Pancreatic Adenocarcinoma. The Johns Hopkins Oncology Center, Baltimore, Maryland Human Gene Therapy. 9: 1951-1971. PMID 9741433 DOI: 10.1089/Hum.1998.9.13-1951  0.317
1998 Ji H, Chang EY, Lin KY, Kurman RJ, Pardoll DM, Wu TC. Antigen-specific immunotherapy for murine lung metastatic tumors expressing human papillomavirus type 16 E7 oncoprotein. International Journal of Cancer. 78: 41-5. PMID 9724092 DOI: 10.1002/(SICI)1097-0215(19980925)78:1<41::AID-IJC8>3.0.CO;2-X  0.731
1998 Greten TF, Slansky JE, Kubota R, Soldan SS, Jaffee EM, Leist TP, Pardoll DM, Jacobson S, Schneck JP. Direct visualization of antigen-specific T cells: HTLV-1 TAX11-19- specific CD8+ T cells are activated in peripheral blood and accumulate in cerebrospinal fluid from HAM/TSP patients Proceedings of the National Academy of Sciences of the United States of America. 95: 7568-7573. PMID 9636190 DOI: 10.1073/Pnas.95.13.7568  0.423
1998 Adler AJ, Marsh DW, Yochum GS, Guzzo JL, Nigam A, Nelson WG, Pardoll DM. CD4+ T cell tolerance to parenchymal self-antigens requires presentation by bone marrow-derived antigen-presenting cells Journal of Experimental Medicine. 187: 1555-1564. PMID 9584134 DOI: 10.1084/Jem.187.10.1555  0.466
1998 Thomas MC, Greten TF, Pardoll DM, Jaffee EM. Enhanced tumor protection by granulocyte-macrophage colony-stimulating factor expression at the site of an allogeneic vaccine. Human Gene Therapy. 9: 835-43. PMID 9581906 DOI: 10.1089/Hum.1998.9.6-835  0.463
1998 Nigam A, Yacavone RF, Zahurak ML, Johns CM, Pardoll DM, Piantadosi S, Levitsky HI, Nelson WG. Immunomodulatory properties of antineoplastic drugs administered in conjunction with GM-CSF-secreting cancer cell vaccines. International Journal of Oncology. 12: 161-70. PMID 9454900 DOI: 10.3892/Ijo.12.1.161  0.658
1998 Staveley-O'Carroll K, Sotomayor E, Montgomery J, Borrello I, Hwang L, Fein S, Pardoll D, Levitsky H. Induction of antigen-specific T cell anergy: An early event in the course of tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 95: 1178-83. PMID 9448305 DOI: 10.1073/Pnas.95.3.1178  0.729
1997 Jaffee EM, Pardoll DM. Considerations for the clinical development of cytokine gene-transduced tumor cell vaccines. Methods (San Diego, Calif.). 12: 143-53. PMID 9184378 DOI: 10.1006/Meth.1997.0463  0.406
1997 Pardoll D. Maturation of cancer vaccines. A meeting report on 'Cancer Vaccines 1996,' sponsored by the Cancer Research Institute, held October 7-9, 1996. Biochimica Et Biophysica Acta. 1332. PMID 9141467 DOI: 10.1016/S0304-419X(97)00005-X  0.308
1996 Huang AY, Gulden PH, Woods AS, Thomas MC, Tong CD, Wang W, Engelhard VH, Pasternack G, Cotter R, Hunt D, Pardoll DM, Jaffee EM. The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product. Proceedings of the National Academy of Sciences of the United States of America. 93: 9730-5. PMID 8790399 DOI: 10.1073/Pnas.93.18.9730  0.8
1996 Fort MM, Pardoll DM. Can bone marrow-derived thymic stromal cells mediate the positive selection of class I-restricted T cells? Cellular Immunology. 171: 74-9. PMID 8660840 DOI: 10.1006/Cimm.1996.0175  0.43
1996 Huang AY, Bruce AT, Pardoll DM, Levitsky HI. Does B7-1 expression confer antigen-presenting cell capacity to tumors in vivo? The Journal of Experimental Medicine. 183: 769-76. PMID 8642281 DOI: 10.1084/Jem.183.3.769  0.702
1996 Huang AY, Bruce AT, Pardoll DM, Levitsky HI. In vivo cross-priming of MHC class I-restricted antigens requires the TAP transporter. Immunity. 4: 349-55. PMID 8612129 DOI: 10.1016/S1074-7613(00)80248-4  0.632
1996 Lin KY, Guarnieri FG, Staveley-O'Carroll KF, Levitsky HI, August JT, Pardoll DM, Wu TC. Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen. Cancer Research. 56: 21-6. PMID 8548765  0.817
1995 Wu TC, Guarnieri FG, Staveley-O'Carroll KF, Viscidi RP, Levitsky HI, Hedrick L, Cho KR, August JT, Pardoll DM. Engineering an intracellular pathway for major histocompatibility complex class II presentation of antigens. Proceedings of the National Academy of Sciences of the United States of America. 92: 11671-5. PMID 8524826 DOI: 10.1073/Pnas.92.25.11671  0.768
1995 Pardoll DM, Beckerleg AM. Exposing the immunology of naked DNA vaccines. Immunity. 3: 165-9. PMID 7648389 DOI: 10.1016/1074-7613(95)90085-3  0.748
1995 Pardoll DM. Paracrine Cytokine Adjuvants in Cancer Immunotherapy Annual Review of Immunology. 13: 399-415. PMID 7612229 DOI: 10.1146/Annurev.Iy.13.040195.002151  0.48
1995 Pan ZK, Ikonomidis G, Lazenby A, Pardoll D, Paterson Y. A recombinant Listeria monocytogenes vaccine expressing a model tumour antigen protects mice against lethal tumour cell challenge and causes regression of established tumours Nature Medicine. 1: 471-477. PMID 7585097 DOI: 10.1038/Nm0595-471  0.417
1994 Golumbek P, Levitsky H, Jaffee L, Pardoll DM. The antitumor immune response as a problem of self-nonself discrimination: implications for immunotherapy. Immunologic Research. 12: 183-92. PMID 8254226 DOI: 10.1007/Bf02918303  0.712
1994 Levitsky HI, Lazenby A, Hayashi RJ, Pardoll DM. In vivo priming of two distinct antitumor effector populations: the role of MHC class I expression. The Journal of Experimental Medicine. 179: 1215-24. PMID 7908321 DOI: 10.1084/Jem.179.4.1215  0.72
1993 Pardoll DM. New strategies for enhancing the immunogenicity of tumors. Current Opinion in Immunology. 5: 719-725. PMID 7694593 DOI: 10.1016/0952-7915(93)90127-E  0.466
1993 Pardoll DM. Genetically Engineered Tumor Vaccines Annals of the New York Academy of Sciences. 690: 301-310. PMID 7690216 DOI: 10.1111/J.1749-6632.1993.Tb44018.X  0.315
1993 Golumbek PT, Hamzeh FM, Jaffee EM, Levitsky H, Lietman PS, Pardoll DM. Herpes simplex-1 virus thymidine kinase gene is unable to completely eliminate live, nonimmunogenic tumor cell vaccines. Journal of Immunotherapy : Official Journal of the Society For Biological Therapy. 12: 224-30. PMID 1335754 DOI: 10.1097/00002371-199211000-00002  0.689
1992 Carrera AC, Baker C, Roberts TM, Pardoll DM. Tyrosine kinase triggering in thymocytes undergoing positive selection. European Journal of Immunology. 22: 2289-94. PMID 1516620 DOI: 10.1002/Eji.1830220917  0.376
1992 Pardoll D. Immunotherapy with cytokine gene-transduced tumor cells: the next wave in gene therapy for cancer. Current Opinion in Oncology. 4: 1124-1129. PMID 1457527 DOI: 10.1097/00001622-199212000-00018  0.413
1992 Pardoll D. New strategies for active immunotherapy with genetically engineered tumor cells. Current Opinion in Immunology. 4: 619-623. PMID 1418729 DOI: 10.1016/0952-7915(92)90037-F  0.452
1992 Heuze F, Pardoll D, Diez E, Ezine S, Jotereau F. Molecular analysis of a pro-T cell clone transformed by Abelson-murine leukemia virus, displaying progressive gamma delta T cell receptor gene rearrangement and surface expression. European Journal of Immunology. 22: 2077-84. PMID 1322302 DOI: 10.1002/Eji.1830220818  0.414
1992 Pardoll D, Golumbek P, Jaffee L, Levitsky H, Dranoff G, Mulligan R. MOLECULAR ENGINEERING OF THE ANTITUMOR IMMUNE RESPONSE Journal of Immunotherapy. 11: 137. DOI: 10.1097/00002371-199202000-00044  0.607
1990 Saito T, Pardoll DM, Fowlkes BJ, Ohno H. A murine thymocyte clone expressing gamma delta T cell receptor mediates natural killer-like cytolytic function and TH1-like lymphokine production. Cellular Immunology. 131: 284-301. PMID 2146987 DOI: 10.1016/0008-8749(90)90255-P  0.441
1989 Janis EM, Kaufmann SH, Schwartz RH, Pardoll DM. Activation of gamma delta T cells in the primary immune response to Mycobacterium tuberculosis. Science (New York, N.Y.). 244: 713-6. PMID 2524098 DOI: 10.1126/Science.2524098  0.435
1989 Fowlkes BJ, Pardoll DM. Molecular and cellular events of T cell development Advances in Immunology. 44: 207-264. PMID 2493727 DOI: 10.1016/S0065-2776(08)60643-4  0.339
1988 Koning F, Kruisbeek AM, Maloy WL, Marusic-Galesic S, Pardoll DM, Shevach EM, Stingl G, Valas R, Yokoyama WM, Coligan JE. T cell receptor gamma/delta chain diversity. The Journal of Experimental Medicine. 167: 676-81. PMID 3258012 DOI: 10.1084/Jem.167.2.676  0.501
1987 Bluestone JA, Pardoll D, Sharrow SO, Fowlkes BJ. Characterization of murine thymocytes with CDS-associated T-cell receptor structures Nature. 326: 82-84. PMID 3102972 DOI: 10.1038/326082A0  0.431
1986 Lew AM, Pardoll DM, Maloy WL, Fowlkes BJ, Kruisbeek A, Cheng SF, Germain RN, Bluestone JA, Schwartz RH, Coligan JE. Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes Science. 234: 1401-1405. PMID 3787252 DOI: 10.1126/Science.3787252  0.388
1980 Vogelstein B, Pardoll DM, Coffey DS. Supercoiled loops and eukaryotic DNA replication Cell. 22: 79-85. PMID 7428042 DOI: 10.1016/0092-8674(80)90156-7  0.413
1980 Pardoll DM, Vogelstein B, Coffey DS. A fixed site of DNA replication in eucaryotic cells Cell. 19: 527-536. PMID 7357619 DOI: 10.1016/0092-8674(80)90527-9  0.422
1979 Shaper JH, Pardoll DM, Kaufmann SH, Barrack ER, Vogelstein B, Coffey DS. The relationship of the nuclear matrix to cellular structure and function Advances in Enzyme Regulation. 17: 213-220,IN3-IN6,221-. DOI: 10.1016/0065-2571(79)90015-3  0.389
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