Jeffrey A. Bluestone - Publications

Affiliations: 
University of Chicago, Chicago, IL 
Area:
Cell Biology, Immunology, Molecular Biology

238 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Muller YD, Nguyen DP, Ferreira LMR, Ho P, Raffin C, Valencia RVB, Congrave-Wilson Z, Roth TL, Eyquem J, Van Gool F, Marson A, Perez L, Wells JA, Bluestone JA, Tang Q. The CD28-Transmembrane Domain Mediates Chimeric Antigen Receptor Heterodimerization With CD28. Frontiers in Immunology. 12: 639818. PMID 33833759 DOI: 10.3389/fimmu.2021.639818  1
2020 Bluestone JA, Tang Q. Solving the Puzzle of Immune Tolerance for β-Cell Replacement Therapy for Type 1 Diabetes. Cell Stem Cell. 27: 505-507. PMID 33007232 DOI: 10.1016/j.stem.2020.09.008  1
2020 Schumann K, Raju SS, Lauber M, Kolb S, Shifrut E, Cortez JT, Skartsis N, Nguyen VQ, Woo JM, Roth TL, Yu R, Nguyen MLT, Simeonov DR, Nguyen DN, Targ S, ... ... Bluestone JA, et al. Functional CRISPR dissection of gene networks controlling human regulatory T cell identity. Nature Immunology. PMID 32989329 DOI: 10.1038/s41590-020-0784-4  1
2020 Cortez JT, Montauti E, Shifrut E, Gatchalian J, Zhang Y, Shaked O, Xu Y, Roth TL, Simeonov DR, Zhang Y, Chen S, Li Z, Woo JM, Ho J, Vogel IA, ... ... Bluestone JA, et al. CRISPR screen in regulatory T cells reveals modulators of Foxp3. Nature. PMID 32499641 DOI: 10.1038/S41586-020-2246-4  0.4
2020 Sawitzki B, Harden PN, Reinke P, Moreau A, Hutchinson JA, Game DS, Tang Q, Guinan EC, Battaglia M, Burlingham WJ, Roberts ISD, Streitz M, Josien R, Böger CA, Scottà C, ... ... Bluestone JA, et al. Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials. Lancet (London, England). 395: 1627-1639. PMID 32446407 DOI: 10.1016/S0140-6736(20)30167-7  1
2020 Roth TL, Li PJ, Blaeschke F, Nies JF, Apathy R, Mowery C, Yu R, Nguyen MLT, Lee Y, Truong A, Hiatt J, Wu D, Nguyen DN, Goodman D, Bluestone JA, et al. Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies. Cell. PMID 32302591 DOI: 10.1016/J.Cell.2020.03.039  0.4
2019 Nguyen DN, Roth TL, Li PJ, Chen PA, Apathy R, Mamedov MR, Vo LT, Tobin VR, Goodman D, Shifrut E, Bluestone JA, Puck JM, Szoka FC, Marson A. Polymer-stabilized Cas9 nanoparticles and modified repair templates increase genome editing efficiency. Nature Biotechnology. PMID 31819258 DOI: 10.1038/S41587-019-0325-6  0.32
2019 Ferreira LMR, Muller YD, Bluestone JA, Tang Q. Next-generation regulatory T cell therapy. Nature Reviews. Drug Discovery. PMID 31541224 DOI: 10.1038/S41573-019-0041-4  1
2019 Azimi CS, Tang Q, Roybal KT, Bluestone JA. NextGen cell-based immunotherapies in cancer and other immune disorders. Current Opinion in Immunology. 59: 79-87. PMID 31071513 DOI: 10.1016/J.Coi.2019.03.007  1
2019 Van Gool F, Nguyen MLT, Mumbach MR, Satpathy AT, Rosenthal WL, Giacometti S, Le DT, Liu W, Brusko TM, Anderson MS, Rudensky AY, Marson A, Chang HY, Bluestone JA. A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells. Immunity. PMID 30709738 DOI: 10.1016/J.Immuni.2018.12.016  0.32
2018 Esensten JH, Muller YD, Bluestone JA, Tang Q. Regulatory T cell therapy for autoimmune and autoinflammatory diseases: the next frontier. The Journal of Allergy and Clinical Immunology. PMID 30367909 DOI: 10.1016/J.Jaci.2018.10.015  1
2018 Bluestone JA, Tang Q. T cells-the next frontier of cell therapy. Science (New York, N.Y.). 362: 154-155. PMID 30309932 DOI: 10.1126/Science.Aau2688  1
2018 Dall'Era M, Pauli ML, Remedios K, Taravati K, Sandoval PM, Putnam AL, Lares A, Haemel A, Tang Q, Hellerstein M, Fitch M, McNamara J, Welch B, Bluestone JA, Wofsy D, et al. Adoptive Regulatory T Cell Therapy in a Patient with Systemic Lupus Erythematosus. Arthritis & Rheumatology (Hoboken, N.J.). PMID 30277008 DOI: 10.1002/Art.40737  1
2018 Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC. Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy. Journal of Immunology (Baltimore, Md. : 1950). PMID 30104245 DOI: 10.4049/Jimmunol.1800578  0.32
2018 Abbas AK, Trotta E, R Simeonov D, Marson A, Bluestone JA. Revisiting IL-2: Biology and therapeutic prospects. Science Immunology. 3. PMID 29980618 DOI: 10.1126/Sciimmunol.Aat1482  0.32
2018 Trotta E, Bessette PH, Silveria SL, Ely LK, Jude KM, Le DT, Holst CR, Coyle A, Potempa M, Lanier LL, Garcia KC, Crellin NK, Rondon IJ, Bluestone JA. A human anti-IL-2 antibody that potentiates regulatory T cells by a structure-based mechanism. Nature Medicine. PMID 29942088 DOI: 10.1038/S41591-018-0070-2  0.32
2018 Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, ... ... Bluestone JA, et al. Author Correction: Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature. PMID 29899441 DOI: 10.1038/S41586-018-0227-7  0.4
2018 Sneddon JB, Tang Q, Stock P, Bluestone JA, Roy S, Desai T, Hebrok M. Stem Cell Therapies for Treating Diabetes: Progress and Remaining Challenges. Cell Stem Cell. 22: 810-823. PMID 29859172 DOI: 10.1016/J.Stem.2018.05.016  1
2018 Spence A, Purtha W, Tam J, Dong S, Kim Y, Ju C, Sterling T, Nakayama M, Robinson WH, Bluestone JA, Anderson MS, Tang Q. Correction for Spence et al., Revealing the specificity of regulatory T cells in murine autoimmune diabetes. Proceedings of the National Academy of Sciences of the United States of America. 115. PMID 29844176 DOI: 10.1073/Pnas.1808331115  1
2018 Spence A, Purtha W, Tam J, Dong S, Kim Y, Ju CH, Sterling T, Nakayama M, Robinson WH, Bluestone JA, Anderson MS, Tang Q. Revealing the specificity of regulatory T cells in murine autoimmune diabetes. Proceedings of the National Academy of Sciences of the United States of America. PMID 29712852 DOI: 10.1073/Pnas.1715590115  1
2018 Sockolosky JT, Trotta E, Parisi G, Picton L, Su LL, Le AC, Chhabra A, Silveria SL, George BM, King IC, Tiffany MR, Jude K, Sibener LV, Baker D, Shizuru JA, ... ... Bluestone JA, et al. Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science (New York, N.Y.). 359: 1037-1042. PMID 29496879 DOI: 10.1126/Science.Aar3246  0.32
2017 Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, et al. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Frontiers in Immunology. 8: 1844. PMID 29379498 DOI: 10.3389/Fimmu.2017.01844  1
2017 Simeonov DR, Gowen BG, Boontanrart M, Roth TL, Gagnon JD, Mumbach MR, Satpathy AT, Lee Y, Bray NL, Chan AY, Lituiev DS, Nguyen ML, Gate RE, Subramaniam M, Li Z, ... ... Bluestone JA, et al. Discovery of stimulation-responsive immune enhancers with CRISPR activation. Nature. PMID 28854172 DOI: 10.1038/Nature23875  0.4
2017 Chandran S, Tang Q, Sarwal M, Laszik ZG, Putnam AL, Lee K, Leung J, Nguyen V, Sigdel T, Tavares EC, Yang JYC, Hellerstein M, Fitch M, Bluestone JA, Vincenti F. Polyclonal Regulatory T cell Therapy for Control of Inflammation in Kidney Transplants. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. PMID 28675676 DOI: 10.1111/Ajt.14415  1
2016 Esensten JH, Bluestone JA, Lim WA. Engineering Therapeutic T Cells: From Synthetic Biology to Clinical Trials. Annual Review of Pathology. PMID 27959633 DOI: 10.1146/Annurev-Pathol-052016-100304  0.44
2016 Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA. CD28 Costimulation: From Mechanism to Therapy. Immunity. 44: 973-88. PMID 27192564 DOI: 10.1016/J.Immuni.2016.04.020  1
2015 Bluestone JA, Buckner JH, Fitch M, Gitelman SE, Gupta S, Hellerstein MK, Herold KC, Lares A, Lee MR, Li K, Liu W, Long SA, Masiello LM, Nguyen V, Putnam AL, et al. Type 1 diabetes immunotherapy using polyclonal regulatory T cells. Science Translational Medicine. 7: 315ra189. PMID 26606968 DOI: 10.1126/Scitranslmed.Aad4134  1
2015 Kishnani PS, Dickson PI, Muldowney L, Lee JJ, Rosenberg A, Abichandani R, Bluestone JA, Burton BK, Dewey M, Freitas A, Gavin D, Griebel D, Hogan M, Holland S, Tanpaiboon P, et al. Immune response to enzyme replacement therapies in lysosomal storage diseases and the role of immune tolerance induction. Molecular Genetics and Metabolism. PMID 26597321 DOI: 10.1016/J.Ymgme.2015.11.001  1
2015 Spence A, Klementowicz JE, Bluestone JA, Tang Q. Targeting Treg signaling for the treatment of autoimmune diseases. Current Opinion in Immunology. 37: 11-20. PMID 26432763 DOI: 10.1016/J.Coi.2015.09.002  1
2015 Schumann K, Lin S, Boyer E, Simeonov DR, Subramaniam M, Gate RE, Haliburton GE, Ye CJ, Bluestone JA, Doudna JA, Marson A. Generation of knock-in primary human T cells using Cas9 ribonucleoproteins. Proceedings of the National Academy of Sciences of the United States of America. 112: 10437-42. PMID 26216948 DOI: 10.1073/Pnas.1512503112  0.4
2015 Molofsky AB, Van Gool F, Liang HE, Van Dyken SJ, Nussbaum JC, Lee J, Bluestone JA, Locksley RM. Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation. Immunity. 43: 161-74. PMID 26092469 DOI: 10.1016/J.Immuni.2015.05.019  1
2015 Fuhrman CA, Yeh WI, Seay HR, Saikumar Lakshmi P, Chopra G, Zhang L, Perry DJ, McClymont SA, Yadav M, Lopez MC, Baker HV, Zhang Y, Li Y, Whitley M, von Schack D, ... ... Bluestone JA, et al. Divergent Phenotypes of Human Regulatory T Cells Expressing the Receptors TIGIT and CD226. Journal of Immunology (Baltimore, Md. : 1950). 195: 145-55. PMID 25994968 DOI: 10.4049/Jimmunol.1402381  0.36
2015 Bluestone JA, Crellin N, Trotta E. IL-2: Change Structure … Change Function. Immunity. 42: 779-81. PMID 25992850 DOI: 10.1016/J.Immuni.2015.05.002  0.32
2015 Bluestone JA, Bour-Jordan H, Cheng M, Anderson M. T cells in the control of organ-specific autoimmunity. The Journal of Clinical Investigation. 125: 2250-60. PMID 25985270 DOI: 10.1172/Jci78089  0.36
2015 Bluestone JA, Trotta E, Xu D. The therapeutic potential of regulatory T cells for the treatment of autoimmune disease. Expert Opinion On Therapeutic Targets. 19: 1091-103. PMID 25881491 DOI: 10.1517/14728222.2015.1037282  0.36
2015 Bluestone JA, Tang Q. Immunotherapy: making the case for precision medicine. Science Translational Medicine. 7: 280ed3. PMID 25810308 DOI: 10.1126/Scitranslmed.Aaa9846  1
2015 DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity. 42: 227-38. PMID 25680271 DOI: 10.1016/J.Immuni.2015.01.007  1
2015 Szot GL, Yadav M, Lang J, Kroon E, Kerr J, Kadoya K, Brandon EP, Baetge EE, Bour-Jordan H, Bluestone JA. Tolerance induction and reversal of diabetes in mice transplanted with human embryonic stem cell-derived pancreatic endoderm. Cell Stem Cell. 16: 148-57. PMID 25533131 DOI: 10.1016/J.Stem.2014.12.001  0.4
2015 Fuhrman CA, Yeh WI, Seay HR, Lakshmi PS, Chopra G, Zhang L, Perry DJ, McClymont SA, Yadav M, Lopez MC, Baker HV, Zhang Y, Li Y, Whitley M, Von Schack D, ... ... Bluestone JA, et al. Divergent phenotypes of human regulatory T cells expressing the receptors TIGIT and CD226 Journal of Immunology. 195: 145-155. DOI: 10.4049/jimmunol.1402381  0.36
2014 Xu P, Bailey-Bucktrout S, Xi Y, Xu D, Du D, Zhang Q, Xiang W, Liu J, Melton A, Sheppard D, Chapman HA, Bluestone JA, Derynck R. Innate antiviral host defense attenuates TGF-β function through IRF3-mediated suppression of Smad signaling. Molecular Cell. 56: 723-37. PMID 25526531 DOI: 10.1016/J.Molcel.2014.11.027  1
2014 Van Gool F, Molofsky AB, Morar MM, Rosenzwajg M, Liang HE, Klatzmann D, Locksley RM, Bluestone JA. Interleukin-5-producing group 2 innate lymphoid cells control eosinophilia induced by interleukin-2 therapy. Blood. 124: 3572-6. PMID 25323825 DOI: 10.1182/Blood-2014-07-587493  1
2014 Folias AE, Penaranda C, Su AL, Bluestone JA, Hebrok M. Aberrant innate immune activation following tissue injury impairs pancreatic regeneration. Plos One. 9: e102125. PMID 25010227 DOI: 10.1371/Journal.Pone.0102125  1
2014 Roep BO, Solvason N, Gottlieb PA, Abreu JR, Harrison LC, Eisenbarth GS, Yu L, Leviten M, Hagopian WA, Buse JB, Von Herrath M, Quan J, King RS, Robinson WH, Utz PJ, et al. Plasmid-encoded proinsulin preserves C-peptide while specifically reducing proinsulin-specific CD8 + T cells in type 1 diabetes Diabetes Technology and Therapeutics. 16: S88. DOI: 10.1089/dia.2014.1510  1
2014 Guleria I, Bupp MG, Dada S, Fife BT, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH. Corrigendum to 'Mechanisms of PDL1-mediated regulation of autoimmune diabetes' [Clin. Immunol. 125 (2007) 16-25] Clinical Immunology. 150: 134. DOI: 10.1016/J.Clim.2013.09.004  1
2013 Gitelman SE, Gottlieb PA, Rigby MR, Felner EI, Willi SM, Fisher LK, Moran A, Gottschalk M, Moore WV, Pinckney A, Keyes-Elstein L, Aggarwal S, Phippard D, Sayre PH, Ding L, ... Bluestone JA, et al. Antithymocyte globulin treatment for patients with recent-onset type 1 diabetes: 12-month results of a randomised, placebo-controlled, phase 2 trial. The Lancet. Diabetes & Endocrinology. 1: 306-16. PMID 24622416 DOI: 10.1089/Dia.2014.1510  1
2013 Bailey-Bucktrout SL, Martinez-Llordella M, Zhou X, Anthony B, Rosenthal W, Luche H, Fehling HJ, Bluestone JA. Self-antigen-driven activation induces instability of regulatory T cells during an inflammatory autoimmune response. Immunity. 39: 949-62. PMID 24238343 DOI: 10.1016/J.Immuni.2013.10.016  1
2013 Tang Q, Bluestone JA. Regulatory T-cell therapy in transplantation: moving to the clinic. Cold Spring Harbor Perspectives in Medicine. 3. PMID 24186492 DOI: 10.1101/Cshperspect.A015552  1
2013 Putnam AL, Safinia N, Medvec A, Laszkowska M, Wray M, Mintz MA, Trotta E, Szot GL, Liu W, Lares A, Lee K, Laing A, Lechler RI, Riley JL, Bluestone JA, et al. Clinical grade manufacturing of human alloantigen-reactive regulatory T cells for use in transplantation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 13: 3010-20. PMID 24102808 DOI: 10.1111/Ajt.12433  1
2013 Martínez-Llordella M, Esensten JH, Bailey-Bucktrout SL, Lipsky RH, Marini A, Chen J, Mughal M, Mattson MP, Taub DD, Bluestone JA. CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response. The Journal of Experimental Medicine. 210: 1603-19. PMID 23878307 DOI: 10.1084/Jem.20122387  1
2013 Wieland Brown LC, Penaranda C, Kashyap PC, Williams BB, Clardy J, Kronenberg M, Sonnenburg JL, Comstock LE, Bluestone JA, Fischbach MA. Production of α-galactosylceramide by a prominent member of the human gut microbiota. Plos Biology. 11: e1001610. PMID 23874157 DOI: 10.1371/Journal.Pbio.1001610  1
2013 de Kouchkovsky D, Esensten JH, Rosenthal WL, Morar MM, Bluestone JA, Jeker LT. microRNA-17-92 regulates IL-10 production by regulatory T cells and control of experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 191: 1594-605. PMID 23858035 DOI: 10.4049/Jimmunol.1203567  1
2013 Bour-Jordan H, Thompson HL, Giampaolo JR, Davini D, Rosenthal W, Bluestone JA. Distinct genetic control of autoimmune neuropathy and diabetes in the non-obese diabetic background. Journal of Autoimmunity. 45: 58-67. PMID 23850635 DOI: 10.1016/J.Jaut.2013.06.005  1
2013 Villalta SA, Lang J, Kubeck S, Kabre B, Szot GL, Calderon B, Wasserfall C, Atkinson MA, Brekken RA, Pullen N, Arch RH, Bluestone JA. Inhibition of VEGFR-2 reverses type 1 diabetes in NOD mice by abrogating insulitis and restoring islet function. Diabetes. 62: 2870-8. PMID 23835340 DOI: 10.2337/Db12-1619  0.4
2013 Herold KC, Gitelman SE, Ehlers MR, Gottlieb PA, Greenbaum CJ, Hagopian W, Boyle KD, Keyes-Elstein L, Aggarwal S, Phippard D, Sayre PH, McNamara J, Bluestone JA. Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders. Diabetes. 62: 3766-74. PMID 23835333 DOI: 10.1089/Dia.2014.1510  1
2013 Baumjohann D, Kageyama R, Clingan JM, Morar MM, Patel S, de Kouchkovsky D, Bannard O, Bluestone JA, Matloubian M, Ansel KM, Jeker LT. The microRNA cluster miR-17∼92 promotes TFH cell differentiation and represses subset-inappropriate gene expression. Nature Immunology. 14: 840-8. PMID 23812098 DOI: 10.1038/Ni.2642  1
2013 Fischbach MA, Bluestone JA, Lim WA. Cell-based therapeutics: the next pillar of medicine. Science Translational Medicine. 5: 179ps7. PMID 23552369 DOI: 10.1126/Scitranslmed.3005568  1
2013 Huang C, Martin S, Pfleger C, Du J, Buckner JH, Bluestone JA, Riley JL, Ziegler SF. Cutting Edge: a novel, human-specific interacting protein couples FOXP3 to a chromatin-remodeling complex that contains KAP1/TRIM28. Journal of Immunology (Baltimore, Md. : 1950). 190: 4470-3. PMID 23543754 DOI: 10.4049/Jimmunol.1203561  1
2013 Herold KC, Vignali DA, Cooke A, Bluestone JA. Type 1 diabetes: translating mechanistic observations into effective clinical outcomes. Nature Reviews. Immunology. 13: 243-56. PMID 23524461 DOI: 10.1038/Nri3422  1
2013 Abbas AK, Benoist C, Bluestone JA, Campbell DJ, Ghosh S, Hori S, Jiang S, Kuchroo VK, Mathis D, Roncarolo MG, Rudensky A, Sakaguchi S, Shevach EM, Vignali DA, Ziegler SF. Regulatory T cells: recommendations to simplify the nomenclature. Nature Immunology. 14: 307-8. PMID 23507634 DOI: 10.1038/Ni.2554  1
2013 Lebastchi J, Deng S, Lebastchi AH, Beshar I, Gitelman S, Willi S, Gottlieb P, Akirav EM, Bluestone JA, Herold KC. Immune therapy and β-cell death in type 1 diabetes. Diabetes. 62: 1676-80. PMID 23423576 DOI: 10.2337/Db12-1207  1
2013 Herold KC, Gitelman SE, Willi SM, Gottlieb PA, Waldron-Lynch F, Devine L, Sherr J, Rosenthal SM, Adi S, Jalaludin MY, Michels AW, Dziura J, Bluestone JA. Teplizumab treatment may improve C-peptide responses in participants with type 1 diabetes after the new-onset period: a randomised controlled trial. Diabetologia. 56: 391-400. PMID 23086558 DOI: 10.1007/S00125-012-2753-4  1
2012 Bluestone JA, Bour-Jordan H. Current and future immunomodulation strategies to restore tolerance in autoimmune diseases. Cold Spring Harbor Perspectives in Biology. 4. PMID 23125012 DOI: 10.1101/Cshperspect.A007542  0.36
2012 Tang Q, Leung J, Melli K, Lay K, Chuu EL, Liu W, Bluestone JA, Kang SM, Peddi VR, Vincenti F. Altered balance between effector T cells and FOXP3+ HELIOS+ regulatory T cells after thymoglobulin induction in kidney transplant recipients. Transplant International : Official Journal of the European Society For Organ Transplantation. 25: 1257-67. PMID 22994802 DOI: 10.1111/J.1432-2277.2012.01565.X  1
2012 Yadav M, Louvet C, Davini D, Gardner JM, Martinez-Llordella M, Bailey-Bucktrout S, Anthony BA, Sverdrup FM, Head R, Kuster DJ, Ruminski P, Weiss D, Von Schack D, Bluestone JA. Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. The Journal of Experimental Medicine. 209: 1713-22, S1-19. PMID 22966003 DOI: 10.1084/Jem.20120822  1
2012 Kim K, An HJ, Jun SH, Kim TJ, Lim SA, Park G, Na HB, Park YI, Hyeon T, Yee C, Bluestone JA, Kim J, Lee KM. Single step isolation and activation of primary CD3 + T lymphocytes using alcohol-dispersed electrospun magnetic nanofibers Nano Letters. 12: 4018-4024. PMID 22784189 DOI: 10.1021/Nl301388D  1
2012 Penaranda C, Kuswanto W, Hofmann J, Kenefeck R, Narendran P, Walker LS, Bluestone JA, Abbas AK, Dooms H. IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 12668-73. PMID 22733744 DOI: 10.1073/Pnas.1203692109  1
2012 Long SA, Rieck M, Sanda S, Bollyky JB, Samuels PL, Goland R, Ahmann A, Rabinovitch A, Aggarwal S, Phippard D, Turka LA, Ehlers MR, Bianchine PJ, Boyle KD, Adah SA, ... Bluestone JA, et al. Rapamycin/IL-2 combination therapy in patients with type 1 diabetes augments Tregs yet transiently impairs β-cell function. Diabetes. 61: 2340-8. PMID 22721971 DOI: 10.1089/Dia.2013.1510  1
2012 Jeker LT, Zhou X, Gershberg K, de Kouchkovsky D, Morar MM, Stadthagen G, Lund AH, Bluestone JA. MicroRNA 10a marks regulatory T cells. Plos One. 7: e36684. PMID 22629323 DOI: 10.1371/Journal.Pone.0036684  1
2012 Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, ... ... Bluestone JA, et al. A resource for the conditional ablation of microRNAs in the mouse. Cell Reports. 1: 385-91. PMID 22570807 DOI: 10.1016/J.Celrep.2012.02.008  1
2012 Beilke JN, Meagher CT, Hosiawa K, Champsaur M, Bluestone JA, Lanier LL. NK cells are not required for spontaneous autoimmune diabetes in NOD mice. Plos One. 7: e36011. PMID 22558306 DOI: 10.1371/Journal.Pone.0036011  1
2012 Jeker LT, Bour-Jordan H, Bluestone JA. Breakdown in peripheral tolerance in type 1 diabetes in mice and humans. Cold Spring Harbor Perspectives in Medicine. 2: a007807. PMID 22393537 DOI: 10.1101/Cshperspect.A007807  0.36
2012 Tang Q, Bluestone JA, Kang SM. CD4(+)Foxp3(+) regulatory T cell therapy in transplantation. Journal of Molecular Cell Biology. 4: 11-21. PMID 22170955 DOI: 10.1093/Jmcb/Mjr047  1
2012 Atkinson MA, Bluestone JA, Eisenbarth GS, Hebrok M, Herold KC, Accili D, Pietropaolo M, Arvan PR, Von Herrath M, Markel DS, Rhodes CJ. How does type 1 diabetes develop? The notion of homicide or β-cell suicide revisited (Diabetes (2011) 60, (1370-1379)) Diabetes. 61: 1648. DOI: 10.2337/Db12-Er06A  1
2011 Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA. Pillars article: CTLA-4 can function as a negative regulator of T cell activation. Immunity. 1994. 1: 405-413. Journal of Immunology (Baltimore, Md. : 1950). 187: 3466-74. PMID 21934098  1
2011 Beyer M, Thabet Y, Müller RU, Sadlon T, Classen S, Lahl K, Basu S, Zhou X, Bailey-Bucktrout SL, Krebs W, Schönfeld EA, Böttcher J, Golovina T, Mayer CT, Hofmann A, ... ... Bluestone JA, et al. Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nature Immunology. 12: 898-907. PMID 21841785 DOI: 10.1038/Ni.2084  1
2011 Herold KC, Bluestone JA. Type 1 diabetes immunotherapy: is the glass half empty or half full? Science Translational Medicine. 3: 95fs1. PMID 21832236 DOI: 10.1126/Scitranslmed.3002981  1
2011 Esplugues E, Huber S, Gagliani N, Hauser AE, Town T, Wan YY, O'Connor W, Rongvaux A, Van Rooijen N, Haberman AM, Iwakura Y, Kuchroo VK, Kolls JK, Bluestone JA, Herold KC, et al. Control of TH17 cells occurs in the small intestine. Nature. 475: 514-8. PMID 21765430 DOI: 10.1038/Nature10228  1
2011 Penaranda C, Tang Q, Bluestone JA. Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 187: 2015-22. PMID 21742976 DOI: 10.4049/Jimmunol.1100713  1
2011 Rainbow DB, Moule C, Fraser HI, Clark J, Howlett SK, Burren O, Christensen M, Moody V, Steward CA, Mohammed JP, Fusakio ME, Masteller EL, Finger EB, Houchins JP, Naf D, ... ... Bluestone JA, et al. Evidence that Cd101 is an autoimmune diabetes gene in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 187: 325-36. PMID 21613616 DOI: 10.4049/Jimmunol.1003523  1
2011 Brennan TV, Tang Q, Liu FC, Hoang V, Bi M, Bluestone JA, Kang SM. Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts. The Journal of Surgical Research. 169: e69-75. PMID 21571317 DOI: 10.1016/J.Jss.2011.03.021  1
2011 Atkinson MA, Bluestone JA, Eisenbarth GS, Hebrok M, Herold KC, Accili D, Pietropaolo M, Arvan PR, Von Herrath M, Markel DS, Rhodes CJ. How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes. 60: 1370-9. PMID 21525508 DOI: 10.2337/Db10-1797  1
2011 Bour-Jordan H, Esensten JH, Martinez-Llordella M, Penaranda C, Stumpf M, Bluestone JA. Intrinsic and extrinsic control of peripheral T-cell tolerance by costimulatory molecules of the CD28/ B7 family. Immunological Reviews. 241: 180-205. PMID 21488898 DOI: 10.1111/J.1600-065X.2011.01011.X  1
2011 McClymont SA, Putnam AL, Lee MR, Esensten JH, Liu W, Hulme MA, Hoffmüller U, Baron U, Olek S, Bluestone JA, Brusko TM. Plasticity of human regulatory T cells in healthy subjects and patients with type 1 diabetes. Journal of Immunology (Baltimore, Md. : 1950). 186: 3918-26. PMID 21368230 DOI: 10.4049/Jimmunol.1003099  1
2011 Nikoopour E, Sandrock C, Huszarik K, Krougly O, Lee-Chan E, Masteller EL, Bluestone JA, Singh B. Cutting edge: vasostatin-1-derived peptide ChgA29-42 is an antigenic epitope of diabetogenic BDC2.5 T cells in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 186: 3831-5. PMID 21357258 DOI: 10.4049/Jimmunol.1003617  0.48
2010 Melton AC, Bailey-Bucktrout SL, Travis MA, Fife BT, Bluestone JA, Sheppard D. Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. The Journal of Clinical Investigation. 120: 4436-44. PMID 21099117 DOI: 10.1172/Jci43786  1
2010 Posselt AM, Szot GL, Frassetto LA, Masharani U, Tavakol M, Amin R, McElroy J, Ramos MD, Kerlan RK, Fong L, Vincenti F, Bluestone JA, Stock PG. Islet transplantation in type 1 diabetic patients using calcineurin inhibitor-free immunosuppressive protocols based on T-cell adhesion or costimulation blockade. Transplantation. 90: 1595-601. PMID 20978464 DOI: 10.1097/Tp.0B013E3181Fe1377  0.4
2010 Grinberg-Bleyer Y, Baeyens A, You S, Elhage R, Fourcade G, Gregoire S, Cagnard N, Carpentier W, Tang Q, Bluestone J, Chatenoud L, Klatzmann D, Salomon BL, Piaggio E. IL-2 reverses established type 1 diabetes in NOD mice by a local effect on pancreatic regulatory T cells. The Journal of Experimental Medicine. 207: 1871-8. PMID 20679400 DOI: 10.1084/Jem.20100209  1
2010 Brusko TM, Koya RC, Zhu S, Lee MR, Putnam AL, McClymont SA, Nishimura MI, Han S, Chang LJ, Atkinson MA, Ribas A, Bluestone JA. Human antigen-specific regulatory T cells generated by T cell receptor gene transfer. Plos One. 5: e11726. PMID 20668510 DOI: 10.1371/Journal.Pone.0011726  1
2010 Shoda L, Kreuwel H, Gadkar K, Zheng Y, Whiting C, Atkinson M, Bluestone J, Mathis D, Young D, Ramanujan S. The Type 1 Diabetes PhysioLab Platform: a validated physiologically based mathematical model of pathogenesis in the non-obese diabetic mouse. Clinical and Experimental Immunology. 161: 250-67. PMID 20491795 DOI: 10.1111/J.1365-2249.2010.04166.X  1
2010 Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature. 464: 1293-300. PMID 20432533 DOI: 10.1038/Nature08933  1
2010 Penaranda C, Tang Q, Ruddle NH, Bluestone JA. Prevention of diabetes by FTY720-mediated stabilization of peri-islet tertiary lymphoid organs. Diabetes. 59: 1461-8. PMID 20299465 DOI: 10.2337/Db09-1129  1
2009 Penaranda C, Bluestone JA. Is antigen specificity of autoreactive T cells the key to islet entry? Immunity. 31: 534-6. PMID 19833083 DOI: 10.1016/J.Immuni.2009.09.006  0.4
2009 Esensten JH, Wofsy D, Bluestone JA. Regulatory T cells as therapeutic targets in rheumatoid arthritis. Nature Reviews. Rheumatology. 5: 560-5. PMID 19798031 DOI: 10.1038/Nrrheum.2009.183  1
2009 Fife BT, Pauken KE, Eagar TN, Obu T, Wu J, Tang Q, Azuma M, Krummel MF, Bluestone JA. Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal. Nature Immunology. 10: 1185-92. PMID 19783989 DOI: 10.1038/Ni.1790  1
2009 Zhou X, Bailey-Bucktrout SL, Jeker LT, Penaranda C, Martínez-Llordella M, Ashby M, Nakayama M, Rosenthal W, Bluestone JA. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nature Immunology. 10: 1000-7. PMID 19633673 DOI: 10.1038/Ni.1774  0.4
2009 Norquay LD, D'Aquino KE, Opare-Addo LM, Kuznetsova A, Haas M, Bluestone JA, White MF. Insulin receptor substrate-2 in beta-cells decreases diabetes in nonobese diabetic mice. Endocrinology. 150: 4531-40. PMID 19574401 DOI: 10.1210/En.2009-0395  1
2009 Esensten JH, Lee MR, Glimcher LH, Bluestone JA. T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function. Journal of Immunology (Baltimore, Md. : 1950). 183: 75-82. PMID 19535634 DOI: 10.4049/Jimmunol.0804154  1
2009 Herold KC, Gitelman S, Greenbaum C, Puck J, Hagopian W, Gottlieb P, Sayre P, Bianchine P, Wong E, Seyfert-Margolis V, Bourcier K, Bluestone JA. Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb Teplizumab preserves insulin production for up to 5 years. Clinical Immunology (Orlando, Fla.). 132: 166-73. PMID 19443276 DOI: 10.1016/J.Clim.2009.04.007  1
2009 Bour-Jordan H, Bluestone JA. Regulating the regulators: costimulatory signals control the homeostasis and function of regulatory T cells. Immunological Reviews. 229: 41-66. PMID 19426214 DOI: 10.1111/J.1600-065X.2009.00775.X  0.36
2009 Louvet C, Kabre BG, Davini DW, Martinier N, Su MA, DeVoss JJ, Rosenthal WL, Anderson MS, Bour-Jordan H, Bluestone JA. A novel myelin P0-specific T cell receptor transgenic mouse develops a fulminant autoimmune peripheral neuropathy. The Journal of Experimental Medicine. 206: 507-14. PMID 19221395 DOI: 10.1084/Jem.20082113  1
2009 Su MA, Stenerson M, Liu W, Putnam A, Conte F, Bluestone JA, Anderson MS. The role of X-linked FOXP3 in the autoimmune susceptibility of Turner Syndrome patients. Clinical Immunology (Orlando, Fla.). 131: 139-44. PMID 19150256 DOI: 10.1016/J.Clim.2008.11.007  1
2009 Putnam AL, Brusko TM, Lee MR, Liu W, Szot GL, Ghosh T, Atkinson MA, Bluestone JA. Expansion of human regulatory T-cells from patients with type 1 diabetes. Diabetes. 58: 652-62. PMID 19074986 DOI: 10.2337/Db08-1168  1
2008 Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA. Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 18895-900. PMID 19015530 DOI: 10.1073/Pnas.0810246105  0.4
2008 Bluestone JA, Liu W, Yabu JM, Laszik ZG, Putnam A, Belingheri M, Gross DM, Townsend RM, Vincenti F. The effect of costimulatory and interleukin 2 receptor blockade on regulatory T cells in renal transplantation American Journal of Transplantation. 8: 2086-2096. PMID 18828769 DOI: 10.1111/J.1600-6143.2008.02377.X  1
2008 Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, Hu C, Wong FS, Szot GL, Bluestone JA, Gordon JI, Chervonsky AV. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature. 455: 1109-13. PMID 18806780 DOI: 10.1038/Nature07336  1
2008 Fife BT, Bluestone JA. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunological Reviews. 224: 166-82. PMID 18759926 DOI: 10.1111/J.1600-065X.2008.00662.X  1
2008 Zhou X, Jeker LT, Fife BT, Zhu S, Anderson MS, McManus MT, Bluestone JA. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. The Journal of Experimental Medicine. 205: 1983-91. PMID 18725525 DOI: 10.1084/Jem.20080707  1
2008 Bluestone JA, Tang Q, Sedwick CE. T regulatory cells in autoimmune diabetes: past challenges, future prospects. Journal of Clinical Immunology. 28: 677-84. PMID 18716861 DOI: 10.1007/S10875-008-9242-Z  1
2008 Brusko TM, Putnam AL, Bluestone JA. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunological Reviews. 223: 371-90. PMID 18613848 DOI: 10.1111/J.1600-065X.2008.00637.X  1
2008 Meagher C, Tang Q, Fife BT, Bour-Jordan H, Wu J, Pardoux C, Bi M, Melli K, Bluestone JA. Spontaneous development of a pancreatic exocrine disease in CD28-deficient NOD mice. Journal of Immunology (Baltimore, Md. : 1950). 180: 7793-803. PMID 18523243 DOI: 10.4049/Jimmunol.180.12.7793  1
2008 Tang Q, Adams JY, Penaranda C, Melli K, Piaggio E, Sgouroudis E, Piccirillo CA, Salomon BL, Bluestone JA. Central Role of Defective Interleukin-2 Production in the Triggering of Islet Autoimmune Destruction Immunity. 28: 687-697. PMID 18468463 DOI: 10.1016/J.Immuni.2008.03.016  1
2008 Tang Q, Bluestone JA. The Foxp3+ regulatory T cell: A jack of all trades, master of regulation Nature Immunology. 9: 239-244. PMID 18285775 DOI: 10.1038/Ni1572  1
2008 Bluestone JA, Hebrok M. Safer, longer-lasting regulatory T cells with beta-catenin. Nature Medicine. 14: 118-9. PMID 18256611 DOI: 10.1038/Nm0208-118  1
2008 Cano DA, Rulifson IC, Heiser PW, Swigart LB, Pelengaris S, German M, Evan GI, Bluestone JA, Hebrok M. Regulated beta-cell regeneration in the adult mouse pancreas. Diabetes. 57: 958-66. PMID 18083786 DOI: 10.2337/Db07-0913  1
2007 Bour-Jordan H, Bluestone JA. B cell depletion: a novel therapy for autoimmune diabetes? Journal of Clinical Investigation. 117: 3642-3645. PMID 18060022 DOI: 10.1172/Jci34236  0.36
2007 Travis MA, Reizis B, Melton AC, Masteller E, Tang Q, Proctor JM, Wang Y, Bernstein X, Huang X, Reichardt LF, Bluestone JA, Sheppard D. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature. 449: 361-5. PMID 17694047 DOI: 10.1038/Nature06110  1
2007 Sherry NA, Chen W, Kushner JA, Glandt M, Tang Q, Tsai S, Santamaria P, Bluestone JA, Brillantes AM, Herold KC. Exendin-4 improves reversal of diabetes in NOD mice treated with anti-CD3 monoclonal antibody by enhancing recovery of beta-cells. Endocrinology. 148: 5136-44. PMID 17673522 DOI: 10.1210/En.2007-0358  1
2007 Guleria I, Gubbels Bupp M, Dada S, Fife B, Tang Q, Ansari MJ, Trikudanathan S, Vadivel N, Fiorina P, Yagita H, Azuma M, Atkinson M, Bluestone JA, Sayegh MH. Mechanisms of PDL1-mediated regulation of autoimmune diabetes. Clinical Immunology (Orlando, Fla.). 125: 16-25. PMID 17627890 DOI: 10.1016/J.Clim.2007.05.013  1
2007 Bour-Jordan H, Salomon BL, Thompson HL, Santos R, Abbas AK, Bluestone JA. Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse. Journal of Immunology (Baltimore, Md. : 1950). 179: 1004-12. PMID 17617592 DOI: 10.4049/Jimmunol.179.2.1004  1
2006 Fife BT, Guleria I, Gubbels Bupp M, Eagar TN, Tang Q, Bour-Jordan H, Yagita H, Azuma M, Sayegh MH, Bluestone JA. Insulin-induced remission in new-onset NOD mice is maintained by the PD-1-PD-L1 pathway. The Journal of Experimental Medicine. 203: 2737-47. PMID 17116737 DOI: 10.1084/Jem.20061577  1
2006 Shapiro AM, Ricordi C, Hering BJ, Auchincloss H, Lindblad R, Robertson RP, Secchi A, Brendel MD, Berney T, Brennan DC, Cagliero E, Alejandro R, Ryan EA, DiMercurio B, Morel P, ... ... Bluestone J, et al. International trial of the Edmonton protocol for islet transplantation. The New England Journal of Medicine. 355: 1318-30. PMID 17005949 DOI: 10.1056/Nejmoa061267  1
2006 Seyfert-Margolis V, Gisler TD, Asare AL, Wang RS, Dosch HM, Brooks-Worrell B, Eisenbarth GS, Palmer JP, Greenbaum CJ, Gitelman SE, Nepom GT, Bluestone JA, Herold KC. Analysis of T-cell assays to measure autoimmune responses in subjects with type 1 diabetes: Results of a blinded controlled study Diabetes. 55: 2588-2594. PMID 16936208 DOI: 10.2337/Db05-1378  1
2006 Tang Q, Bluestone JA. Regulatory T-cell physiology and application to treat autoimmunity. Immunological Reviews. 212: 217-37. PMID 16903917 DOI: 10.1111/J.0105-2896.2006.00421.X  1
2006 Fife BT, Griffin MD, Abbas AK, Locksley RM, Bluestone JA. Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist. The Journal of Clinical Investigation. 116: 2252-61. PMID 16886063 DOI: 10.1172/Jci27856  1
2006 Scalapino KJ, Tang Q, Bluestone JA, Bonyhadi ML, Daikh DI. Suppression of disease in New Zealand Black/New Zealand White lupus-prone mice by adoptive transfer of ex vivo expanded regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 177: 1451-9. PMID 16849451 DOI: 10.4049/Jimmunol.177.3.1451  1
2006 Liu W, Putnam AL, Xu-Yu Z, Szot GL, Lee MR, Zhu S, Gottlieb PA, Kapranov P, Gingeras TR, Fazekas de St Groth B, Clayberger C, Soper DM, Ziegler SF, Bluestone JA. CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. The Journal of Experimental Medicine. 203: 1701-11. PMID 16818678 DOI: 10.1084/Jem.20060772  1
2006 Tang Q, Bluestone JA. Plasmacytoid DCs and T(reg) cells: casual acquaintance or monogamous relationship? Nature Immunology. 7: 551-3. PMID 16715063 DOI: 10.1038/Ni0606-551  1
2006 Bresson D, Togher L, Rodrigo E, Chen Y, Bluestone JA, Herold KC, Von Herrath M. Anti-CD3 and nasal proinsulin combination therapy enhances remission from recentonset autoimmune diabetes by inducing Tregs Journal of Clinical Investigation. 116: 1371-1381. PMID 16628253 DOI: 10.1172/Jci27191  1
2006 Masteller EL, Tang Q, Bluestone JA. Antigen-specific regulatory T cells--ex vivo expansion and therapeutic potential. Seminars in Immunology. 18: 103-10. PMID 16458533 DOI: 10.1016/J.Smim.2006.01.004  1
2006 Tang Q, Adams JY, Tooley AJ, Bi M, Fife BT, Serra P, Santamaria P, Locksley RM, Krummel MF, Bluestone JA. Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice. Nature Immunology. 7: 83-92. PMID 16311599 DOI: 10.1038/Ni1289  1
2006 Gross DM, Earle KE, Bluestone JA, Tang Q. Regulatory T cells and their role in type 1 diabetes Current Opinion in Endocrinology and Diabetes. 13: 319-324. DOI: 10.1097/01.Med.0000235320.23917.C5  1
2005 Knoechel B, Lohr J, Kahn E, Bluestone JA, Abbas AK. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. The Journal of Experimental Medicine. 202: 1375-86. PMID 16287710 DOI: 10.1084/Jem.20050855  0.32
2005 Bour-Jordan H, Thompson HL, Bluestone JA. Distinct effector mechanisms in the development of autoimmune neuropathy versus diabetes in nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 175: 5649-55. PMID 16237054 DOI: 10.4049/Jimmunol.175.9.5649  1
2005 Bluestone JA, Tang Q. How do CD4+CD25+ regulatory T cells control autoimmunity? Current Opinion in Immunology. 17: 638-42. PMID 16209918 DOI: 10.1016/J.Coi.2005.09.002  1
2005 Bisikirska B, Colgan J, Luban J, Bluestone JA, Herold KC. TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. The Journal of Clinical Investigation. 115: 2904-13. PMID 16167085 DOI: 10.1172/Jci23961  1
2005 Dai YD, Jensen KP, Lehuen A, Masteller EL, Bluestone JA, Wilson DB, Sercarz EE. A peptide of glutamic acid decarboxylase 65 can recruit and expand a diabetogenic T cell clone, BDC2.5, in the pancreas. Journal of Immunology (Baltimore, Md. : 1950). 175: 3621-7. PMID 16148106 DOI: 10.4049/Jimmunol.175.6.3621  0.48
2005 Masteller EL, Warner MR, Tang Q, Tarbell KV, McDevitt H, Bluestone JA. Expansion of functional endogenous antigen-specific CD4+CD25+ regulatory T cells from nonobese diabetic mice. Journal of Immunology (Baltimore, Md. : 1950). 175: 3053-9. PMID 16116193 DOI: 10.4049/Jimmunol.175.5.3053  1
2005 Shoda LK, Young DL, Ramanujan S, Whiting CC, Atkinson MA, Bluestone JA, Eisenbarth GS, Mathis D, Rossini AA, Campbell SE, Kahn R, Kreuwel HT. A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity. 23: 115-26. PMID 16111631 DOI: 10.1016/J.Immuni.2005.08.002  1
2005 Chikuma S, Abbas AK, Bluestone JA. B7-independent inhibition of T cells by CTLA-4. Journal of Immunology (Baltimore, Md. : 1950). 175: 177-81. PMID 15972645 DOI: 10.4049/Jimmunol.175.1.177  0.32
2005 Earle KE, Tang Q, Zhou X, Liu W, Zhu S, Bonyhadi ML, Bluestone JA. In vitro expanded human CD4+CD25+ regulatory T cells suppress effector T cell proliferation. Clinical Immunology (Orlando, Fla.). 115: 3-9. PMID 15870014 DOI: 10.1016/J.Clim.2005.02.017  1
2005 Loser K, Scherer A, Krummen MBW, Varga G, Higuchi T, Schwarz T, Sharpe AH, Grabbe S, Bluestone JA, Beissert S. An important role of CD80/CD86-CTLA-4 signaling during photocarcinogenesis in mice Journal of Immunology. 174: 5298-5305. PMID 15843526 DOI: 10.4049/Jimmunol.174.9.5298  1
2005 Bezbradica JS, Stanic AK, Matsuki N, Bour-Jordan H, Bluestone JA, Thomas JW, Unutmaz D, Van Kaer L, Joyce S. Distinct roles of dendritic cells and B cells in Va14Ja18 natural T cell activation in vivo. Journal of Immunology (Baltimore, Md. : 1950). 174: 4696-705. PMID 15814694 DOI: 10.4049/Jimmunol.174.8.4696  1
2005 Anderson MS, Bluestone JA. The NOD mouse: A model of immune dysregulation Annual Review of Immunology. 23: 447-485. PMID 15771578 DOI: 10.1146/Annurev.Immunol.23.021704.115643  1
2004 Tang Q, Boden EK, Henriksen KJ, Bour-Jordan H, Bi M, Bluestone JA. Distinct roles of CTLA-4 and TGF-beta in CD4+CD25+ regulatory T cell function. European Journal of Immunology. 34: 2996-3005. PMID 15468055 DOI: 10.1002/Eji.200425143  1
2004 Bour-Jordan H, Salomon BL, Thompson HL, Szot GL, Bernhard MR, Bluestone JA. Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells. The Journal of Clinical Investigation. 114: 979-87. PMID 15467837 DOI: 10.1172/Jci20483  1
2004 Bluestone JA, Tang Q. Therapeutic vaccination using CD4+CD25+ antigen-specific regulatory T cells. Proceedings of the National Academy of Sciences of the United States of America. 101: 14622-6. PMID 15322272 DOI: 10.1073/Pnas.0405234101  1
2004 Ogasawara K, Hamerman JA, Ehrlich LR, Bour-Jordan H, Santamaria P, Bluestone JA, Lanier LL. NKG2D blockade prevents autoimmune diabetes in NOD mice. Immunity. 20: 757-67. PMID 15189740 DOI: 10.1016/J.Immuni.2004.05.008  1
2004 Eagar TN, Turley DM, Padilla J, Karandikar NJ, Tan L, Bluestone JA, Miller SD. CTLA-4 regulates expansion and differentiation of Th1 cells following induction of peripheral T cell tolerance. Journal of Immunology (Baltimore, Md. : 1950). 172: 7442-50. PMID 15187122 DOI: 10.4049/Jimmunol.172.12.7442  1
2004 Tang Q, Henriksen KJ, Bi M, Finger EB, Szot G, Ye J, Masteller EL, McDevitt H, Bonyhadi M, Bluestone JA. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. The Journal of Experimental Medicine. 199: 1455-65. PMID 15184499 DOI: 10.1084/Jem.20040139  1
2004 Eagar TN, Tang Q, Wolfe M, He Y, Pear WS, Bluestone JA. Notch 1 signaling regulates peripheral T cell activation. Immunity. 20: 407-15. PMID 15084270 DOI: 10.1016/S1074-7613(04)00081-0  1
2003 Boden E, Tang Q, Bour-Jordan H, Bluestone JA. The role of CD28 and CTLA4 in the function and homeostasis of CD4+CD25+ regulatory T cells. Novartis Foundation Symposium. 252: 55-63; discussion 63. PMID 14609212 DOI: 10.1002/0470871628.Ch5  1
2003 Masteller EL, Warner MR, Ferlin W, Judkowski V, Wilson D, Glaichenhaus N, Bluestone JA. Peptide-MHC class II dimers as therapeutics to modulate antigen-specific T cell responses in autoimmune diabetes. Journal of Immunology (Baltimore, Md. : 1950). 171: 5587-95. PMID 14607967 DOI: 10.4049/Jimmunol.171.10.5587  1
2003 Tang Q, Henriksen KJ, Boden EK, Tooley AJ, Ye J, Subudhi SK, Zheng XX, Strom TB, Bluestone JA. Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 3348-52. PMID 14500627 DOI: 10.4049/Jimmunol.171.7.3348  1
2003 Starwalt SE, Masteller EL, Bluestone JA, Kranz DM. Directed evolution of a single-chain class II MHC product by yeast display. Protein Engineering. 16: 147-56. PMID 12676983 DOI: 10.1093/Proeng/Gzg018  0.48
2003 Bluestone JA, Abbas AK. Natural versus adaptive regulatory T cells. Nature Reviews. Immunology. 3: 253-7. PMID 12658273 DOI: 10.1038/Nri1032  0.32
2003 Tang Q, Smith JA, Szot GL, Zhou P, Alegre ML, Henriksen KJ, Thompson CB, Bluestone JA. CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo. Journal of Immunology (Baltimore, Md. : 1950). 170: 1510-6. PMID 12538715 DOI: 10.4049/Jimmunol.170.3.1510  1
2003 Ogasawara K, Hamerman JA, Hsin H, Chikuma S, Bour-Jordan H, Chen T, Pertel T, Carnaud C, Bluestone JA, Lanier LL. Impairment of NK cell function by NKG2D modulation in NOD mice. Immunity. 18: 41-51. PMID 12530974 DOI: 10.1016/S1074-7613(02)00505-8  1
2003 Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA. CTLA-4 regulates the requirement for cytokine-induced signals in T(H)2 lineage commitment. Nature Immunology. 4: 182-8. PMID 12524538 DOI: 10.1038/Ni884  1
2002 Utset TO, Auger JA, Peace D, Zivin RA, Xu D, Jolliffe L, Alegre ML, Bluestone JA, Clark MR. Modified anti-CD3 therapy in psoriatic arthritis: a phase I/II clinical trial. The Journal of Rheumatology. 29: 1907-13. PMID 12233885  0.44
2002 Masteller EL, Bluestone JA. Immunotherapy of insulin-dependent diabetes mellitus. Current Opinion in Immunology. 14: 652-659. PMID 12183168 DOI: 10.1016/S0952-7915(02)00375-8  0.48
2002 Rulifson IC, Szot GL, Palmer E, Bluestone JA. Inability to induce tolerance through direct antigen presentation. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 2: 510-9. PMID 12118894 DOI: 10.1034/J.1600-6143.2002.20604.X  0.4
2002 Hwang KW, Sweatt WB, Brown IE, Blank C, Gajewski TF, Bluestone JA, Alegre ML. Cutting edge: Targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells Journal of Immunology. 169: 633-637. PMID 12097362 DOI: 10.4049/Jimmunol.169.2.633  1
2002 Herold KC, Hagopian W, Auger JA, Poumian-Ruiz E, Taylor L, Donaldson D, Gitelman SE, Harlan DM, Xu D, Zivin RA, Bluestone JA. Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. The New England Journal of Medicine. 346: 1692-8. PMID 12037148 DOI: 10.1056/Nejmoa012864  0.4
2002 Tang Q, Subudhi SK, Henriksen KJ, Long CG, Vives F, Bluestone JA. The Src family kinase Fyn mediates signals induced by TCR antagonists. Journal of Immunology (Baltimore, Md. : 1950). 168: 4480-7. PMID 11970992 DOI: 10.4049/Jimmunol.168.9.4480  1
2002 Eagar TN, Karandikar NJ, Bluestone JA, Miller SD. The role of CTLA-4 in induction and maintenance of peripheral T cell tolerance. European Journal of Immunology. 32: 972-81. PMID 11920563 DOI: 10.1002/1521-4141(200204)32:4<972::Aid-Immu972>3.0.Co;2-M  1
2001 Szot GL, Zhou P, Rulifson I, Wang J, Guo Z, Kim O, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML. Different Mechanisms of Cardiac Allograft Rejection in Wildtype and CD28-deficient Mice American Journal of Transplantation. 1: 38-46. PMID 12095035 DOI: 10.1034/J.1600-6143.2001.010108.X  1
2001 Salomon B, Rhee L, Bour-Jordan H, Hsin H, Montag A, Soliven B, Arcella J, Girvin AM, Padilla J, Miller SD, Bluestone JA. Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice. The Journal of Experimental Medicine. 194: 677-84. PMID 11535635 DOI: 10.1084/Jem.194.5.677  1
2001 O'Herrin SM, Slansky JE, Tang Q, Markiewicz MA, Gajewski TF, Pardoll DM, Schneck JP, Bluestone JA. Antigen-specific blockade of T cells in vivo using dimeric MHC peptide Journal of Immunology. 167: 2555-2560. PMID 11509595 DOI: 10.4049/Jimmunol.167.5.2555  1
2001 Tesciuba AG, Subudhi S, Rother RP, Faas SJ, Frantz AM, Elliot D, Weinstock J, Matis LA, Bluestone JA, Sperling AI. Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease. Journal of Immunology (Baltimore, Md. : 1950). 167: 1996-2003. PMID 11489981 DOI: 10.4049/Jimmunol.167.4.1996  0.48
2001 Sperling AI, Bluestone JA. ICOS costimulation: It's not just for TH2 cells anymore. Nature Immunology. 2: 573-4. PMID 11429535 DOI: 10.1038/89709  0.48
2001 Wu Q, Salomon B, Chen M, Wang Y, Hoffman LM, Bluestone JA, Fu YX. Reversal of spontaneous autoimmune insulitis in nonobese diabetic mice by soluble lymphotoxin receptor Journal of Experimental Medicine. 193: 1327-1332. PMID 11390440 DOI: 10.1084/Jem.193.11.1327  1
2001 Donepudi M, Raychaudhuri P, Bluestone JA, Mokyr MB. Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells. Journal of Immunology (Baltimore, Md. : 1950). 166: 6491-9. PMID 11359799 DOI: 10.4049/Jimmunol.166.11.6491  1
2001 Alegre M, Fallarino F, Zhou P, Frauwirth K, Thistlethwaite J, Newell K, Gajewski T, Bluestone J. Transplantation and the CD28/CTLA4/B7 pathway Transplantation Proceedings. 33: 209-211. PMID 11266782 DOI: 10.1016/S0041-1345(00)01977-1  1
2001 Griffin MD, Holman PO, Tang Q, Ashourian N, Korthäuer U, Kranz DM, Bluestone JA. Development and applications of surface-linked single chain antibodies against T-cell antigens. Journal of Immunological Methods. 248: 77-90. PMID 11223070 DOI: 10.1016/S0022-1759(00)00344-6  1
2000 Zhou P, Szot GL, Guo Z, Kim O, He G, Wang J, Grusby MJ, Newell KA, Thistlethwaite JR, Bluestone JA, Alegre ML. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. Journal of Immunology (Baltimore, Md. : 1950). 165: 5580-7. PMID 11067913 DOI: 10.4049/Jimmunol.165.10.5580  1
2000 Karandikar NJ, Eagar TN, Vanderlugt CL, Bluestone JA, Miller SD. CTLA-4 downregulates epitope spreading and mediates remission in relapsing experimental autoimmune encephalomyelitis. Journal of Neuroimmunology. 109: 173-80. PMID 10996219 DOI: 10.1016/S0165-5728(00)00322-2  1
2000 Neville KL, Dal Canto MC, Bluestone JA, Miller SD. CD28 costimulatory blockade exacerbates disease severity and accelerates epitope spreading in a virus-induced autoimmune disease. Journal of Virology. 74: 8349-57. PMID 10954534 DOI: 10.1128/Jvi.74.18.8349-8357.2000  1
2000 Sciammas R, Bluestone JA. TCRgammadelta cells and viruses. Microbes and Infection. 1: 203-12. PMID 10801231 DOI: 10.1016/S1286-4579(99)80035-5  0.36
2000 Salomon B, Lenschow DJ, Rhee L, Ashourian N, Singh B, Sharpe A, Bluestone JA. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 12: 431-440. PMID 10795741 DOI: 10.1016/S1074-7613(00)80195-8  0.44
2000 Griffin MD, Hong DK, Holman PO, Lee KM, Whitters MJ, O'Herrin SM, Fallarino F, Collins M, Segal DM, Gajewski TF, Kranz DM, Bluestone JA. Blockade of T cell activation using a surface-linked single-chain antibody to CTLA-4 (CD152). Journal of Immunology (Baltimore, Md. : 1950). 164: 4433-42. PMID 10779742 DOI: 10.4049/Jimmunol.164.9.4433  0.4
2000 Vanderlugt CL, Neville KL, Nikcevich KM, Eagar TN, Bluestone JA, Miller SD. Pathologic role and temporal appearance of newly emerging autoepitopes in relapsing experimental autoimmune encephalomyelitis. Journal of Immunology (Baltimore, Md. : 1950). 164: 670-8. PMID 10623809 DOI: 10.4049/Jimmunol.164.2.670  1
2000 Korthäuer U, Nagel W, Davis EM, Le Beau MM, Menon RS, Mitchell EO, Kozak CA, Kolanus W, Bluestone JA. Anergic T lymphocytes selectively express an integrin regulatory protein of the cytohesin family. Journal of Immunology (Baltimore, Md. : 1950). 164: 308-18. PMID 10605025 DOI: 10.4049/Jimmunol.164.1.308  0.48
2000 Girvin AM, Dal Canto MC, Rhee L, Salomon B, Sharpe A, Bluestone JA, Miller SD. A critical role for B7/CD28 costimulation in experimental autoimmune encephalomyelitis: a comparative study using costimulatory molecule-deficient mice and monoclonal antibody blockade. Journal of Immunology (Baltimore, Md. : 1950). 164: 136-43. PMID 10605004 DOI: 10.4049/Jimmunol.164.1.136  1
1999 Rajagopal K, Sommers CL, Decker DC, Mitchell EO, Korthauer U, Sperling AI, Kozak CA, Love PE, Bluestone JA. RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. The Journal of Experimental Medicine. 190: 1657-68. PMID 10587356 DOI: 10.1084/Jem.190.11.1657  0.48
1999 Theriault BR, Thistlethwaite JR, Levisetti MG, Wardrip CL, Szot G, Bruce DS, Rilo H, Li X, Gray GS, Bluestone JA, Padrid PA. Induction, maintenance, and reversal of streptozotocin-induced insulin-dependent diabetes mellitus in the juvenile cynomolgus monkey (Macaca fascilularis). Transplantation. 68: 331-7. PMID 10459535 DOI: 10.1097/00007890-199908150-00003  1
1998 Lee KM, Chuang E, Griffin M, Khattri R, Hong DK, Zhang W, Straus D, Samelson LE, Thompson CB, Bluestone JA. Molecular Basis of T Cell Inactivation by CTLA-4 Science. 282: 2263-2266. PMID 9856951 DOI: 10.1126/Science.282.5397.2263  0.4
1998 Vanderlugt CL, Begolka WS, Neville KL, Katz-Levy Y, Howard LM, Eagar TN, Bluestone JA, Miller SD. The functional significance of epitope spreading and its regulation by co-stimulatory molecules. Immunological Reviews. 164: 63-72. PMID 9795764 DOI: 10.1111/J.1600-065X.1998.Tb01208.X  1
1998 Neville KL, Bluestone JA, Miller SD. Interference with costimulation alters disease course in Theiler's Murine Encephalomyelitis Virus-Induced Demyelinating Disease (TMEV-IDD) Faseb Journal. 12: A1100. DOI: 10.1016/S0165-5728(98)91533-8  1
1997 Vanderlugt CL, Karandikar NJ, Lenschow DJ, Dal Canto MC, Bluestone JA, Miller SD. Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE. Journal of Neuroimmunology. 79: 113-8. PMID 9394783 DOI: 10.1016/S0165-5728(97)00108-2  0.44
1997 Smith JA, Bluestone JA. T cell inactivation and cytokine deviation promoted by anti-CD3 mAbs. Current Opinion in Immunology. 9: 648-654. PMID 9368773 DOI: 10.1016/S0952-7915(97)80044-1  0.4
1997 Sciammas R, Kodukula P, Tang Q, Hendricks RL, Bluestone JA. T cell receptor-gamma/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis. The Journal of Experimental Medicine. 185: 1969-75. PMID 9166426 DOI: 10.1084/Jem.185.11.1969  1
1997 Smith JA, Tso JY, Clark MR, Cole MS, Bluestone JA. Nonmitogenic anti-CD3 monoclonal antibodies deliver a partial T cell receptor signal and induce clonal anergy. The Journal of Experimental Medicine. 185: 1413-22. PMID 9126922 DOI: 10.1084/Jem.185.8.1413  1
1997 Sperling AI, Bluestone JA. The complexities of T-cell co-stimulation: CD28 and beyond. Immunological Reviews. 153: 155-82. PMID 9010723 DOI: 10.1111/J.1600-065X.1996.Tb00924.X  0.48
1997 Rulifson IC, Sperling AI, Fields PE, Fitch FW, Bluestone JA. CD28 costimulation promotes the production of Th2 cytokines. Journal of Immunology (Baltimore, Md. : 1950). 158: 658-65. PMID 8992981  1
1996 Sperling AI, Auger JA, Ehst BD, Rulifson IC, Thompson CB, Bluestone JA. CD28/B7 Interactions Deliver a Unique Signal to Naive T Cells That Regulates Cell Survival but Not Early Proliferation Journal of Immunology. 157: 3909-3917. PMID 8892622  1
1996 Lenschow DJ, Walunas TL, Bluestone JA. Cd28/B7 System Of T Cell Costimulation Annual Review of Immunology. 14: 233-258. PMID 8717514 DOI: 10.1146/Annurev.Immunol.14.1.233  0.44
1996 Bluestone JA, Khattri R, Sciammas R, Sperling AI. TCR gamma delta cells: a specialized T-cell subset in the immune system. Annual Review of Cell and Developmental Biology. 11: 307-53. PMID 8689560 DOI: 10.1146/Annurev.Cb.11.110195.001515  0.48
1996 La Motte RN, Rubin MA, Barr E, Leiden JM, Bluestone JA, Mokyr MB. Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule. Cancer Immunology, Immunotherapy : Cii. 42: 161-9. PMID 8640844 DOI: 10.1007/S002620050266  1
1995 DeLuca D, Bluestone JA, Shultz LD, Sharrow SO, Tatsumi Y. Programmed differentiation of murine thymocytes during fetal thymus organ culture Journal of Immunological Methods. 178: 13-29. PMID 7829862 DOI: 10.1016/0022-1759(94)00236-P  1
1995 Hu Q, Davidson D, Schwartzberg PL, Macchiarini F, Lenardo MJ, Bluestone JA, Matis LA. Identification of Rlk, a novel protein tyrosine kinase with predominant expression in the T cell lineage Journal of Biological Chemistry. 270: 1928-1934. PMID 7829530 DOI: 10.1074/Jbc.270.4.1928  1
1995 Alegre ML, Lenschow DJ, Bluestone JA. Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors Digestive Diseases and Sciences. 40: 58-64. PMID 7821120 DOI: 10.1007/Bf02063942  1
1995 Sperling AI, Green JM, Mosley RL, Smith PL, DiPaolo RJ, Klein JR, Bluestone JA, Thompson CB. CD43 is a murine T cell costimulatory receptor that functions independently of CD28. The Journal of Experimental Medicine. 182: 139-46. PMID 7790813 DOI: 10.1084/Jem.182.1.139  1
1995 Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 Immunity. 3: 541-547. PMID 7584144 DOI: 10.1016/1074-7613(95)90125-6  1
1995 Lenschow DJ, Ho SC, Sattar H, Rhee L, Gray G, Nabavi N, Herold KC, Bluestone JA. Differential effects of anti-B7-1 and anti-B7-2 monoclonal antibody treatment on the development of diabetes in the nonobese diabetic mouse. The Journal of Experimental Medicine. 181: 1145-55. PMID 7532678 DOI: 10.1084/Jem.181.3.1145  1
1995 Lenschow DJ, Zeng Y, Hathcock KS, Zuckerman LA, Freeman G, Thistlethwaite JR, Gray GS, Hodes RJ, Bluestone JA. Inhibition of transplant rejection following treatment with anti-B7-2 and anti-B7-1 antibodies. Transplantation. 60: 1171-8. PMID 7482727 DOI: 10.1097/00007890-199511270-00019  1
1994 Walunas TL, Lenschow DJ, Bakker CY, Linsley PS, Freeman GJ, Green JM, Thompson CB, Bluestone JA. CTLA-4 can function as a negative regulator of T cell activation Immunity. 1: 405-413. PMID 7882171 DOI: 10.1016/1074-7613(94)90071-X  0.44
1994 Alegre M-, Peterson LJ, Xu D, Sattar HA, Jeyarajah DR, Kowalkowski K, Thistlethwaite JR, Zivin RA, Jolliffe L, Bluestone JA. A non-activating "humanized" anti-CD3 monoclonal antibody retains immunosuppressive properties in vivo. Transplantation. 57: 1537-1543. DOI: 10.1097/00007890-199457110-00001  0.36
1994 Zeng Y, Gage A, Montag A, Rothlein R, Thistlethwaite JR, Bluestone JA. Inhibition Of Transplant Rejection By Pretreatment Of Xenogeneic Pancreatic Islet Cells With Anti-Icam-1 Antibodies Transplantation. 58: 681-689. DOI: 10.1097/00007890-199409000-00008  0.36
1993 Dent AL, Matis LA, Bluestone JA, Hedrick SM. Evidence for programmed cell death of self-reactive γδ T cell receptor-positive thymocytes European Journal of Immunology. 23: 2482-2487. PMID 8405049 DOI: 10.1002/Eji.1830231016  1
1993 Qian D, Sperling AI, Lancki DW, Tatsumi Y, Barrett TA, Bluestone JA, Fitch FW. The gamma chain of the high-affinity receptor for IgE is a major functional subunit of the T-cell antigen receptor complex in gamma delta T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 90: 11875-9. PMID 8265641 DOI: 10.1073/Pnas.90.24.11875  1
1993 Sydora BC, Mixter PF, Houlden B, Hershberg R, Levy R, Comay M, Bluestone J, Kronenberg M. T-Cell Receptor γδ Diversity and Specificity of Intestinal Intraepithelial Lymphocytes: Analysis of IEL-Derived Hybridomas Cellular Immunology. 152: 305-322. PMID 8258140 DOI: 10.1006/Cimm.1993.1293  1
1993 Lenschow DJ, Bluestone JA. T cell co-stimulation and in vivo tolerance Current Opinion in Immunology. 5: 747-752. PMID 7694594 DOI: 10.1016/0952-7915(93)90132-C  0.44
1993 Lenschow DJ, Su GH, Zuckerman LA, Nabavi N, Jellis CL, Gray GS, Miller J, Bluestone JA. Expression and functional significance of an additional ligand for CTLA-4. Proceedings of the National Academy of Sciences of the United States of America. 90: 11054-8. PMID 7504292 DOI: 10.1073/Pnas.90.23.11054  1
1992 Barrett TA, Delvy ML, Kennedy DM, Lefrancois L, Matis LA, Dent AL, Hedrick SM, Bluestone JA. Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue. The Journal of Experimental Medicine. 175: 65-70. PMID 1730927 DOI: 10.1084/Jem.175.1.65  1
1991 Woodle ES, Thistlethwaite JR, Ghobrial IA, Jolliffe LK, Stuart FP, Bluestone JA. OKT3 F(ab')2 fragments--retention of the immunosuppressive properties of whole antibody with marked reduction in T cell activation and lymphokine release. Transplantation. 52: 354-360. PMID 1908148 DOI: 10.1097/00007890-199108000-00033  0.36
1991 Newell KA, Ellenhorn JDI, Bruce DS, Bluestone JA. In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor Proceedings of the National Academy of Sciences of the United States of America. 88: 1074-1078. PMID 1899481 DOI: 10.1073/Pnas.88.3.1074  1
1991 Lefrancois L, LeCorre R, Mayo J, Bluestone JA, Goodman T. Selection of Vδ+ T cell receptors of intestinal intraepithelial lymphocytes is dependent on Class II histocompatibility antigen expression Current Topics in Microbiology and Immunology. 173: 255-267. PMID 1833152 DOI: 10.1007/978-3-642-76492-9_36  1
1991 Newell KA, Ellenhorn JDI, Hirsch R, Bluestone JA. Immunopotentiation of anti-viral and anti-tumor immune responses using anti-T cell receptor antibodies and mitogens Annals of the New York Academy of Sciences. 636: 279-287. PMID 1793214 DOI: 10.1111/J.1749-6632.1991.Tb33458.X  1
1991 Bluestone JA, Cron RQ, Barrett TA, Houlden B, Sperling AI, Dent A, Hedrick S, Rellahan B, Matis LA. Repertoire development and ligand specificity of murine TCR gamma delta cells. Immunological Reviews. 120: 5-33. PMID 1650760 DOI: 10.1111/J.1600-065X.1991.Tb00585.X  0.48
1991 Woodle ES, Thistlethwaite JR, Jolliffe LK, Fucello AJ, Stuart FP, Bluestone JA. Anti-CD3 monoclonal antibody therapy. An approach toward optimization by in vitro analysis of new anti-CD3 antibodies. Transplantation. 52: 361-368. DOI: 10.1097/00007890-199108000-00034  0.36
1990 Grusby MJ, Nabavi N, Wong H, Dick RF, Bluestone JA, Schotz MC, Glimcher LH. Cloning of an interleukin-4 inducible gene from cytotoxic T lymphocytes and its identification as a lipase Cell. 60: 451-459. PMID 2302735 DOI: 10.1016/0092-8674(90)90596-7  1
1990 Lefrancois L, LeCorre R, Mayo J, Bluestone JA, Goodman T. Extrathymic selection of TCR γδ+ T cells by class II major histocompatibility complex molecules Cell. 63: 333-340. PMID 2208290 DOI: 10.1016/0092-8674(90)90166-C  1
1990 Ellenhorn JDI, Woodle ES, Ghobreal I, Thistlethwaite JR, Bluestone JA. Activation of human T cells in vivo following treatment of transplant recipients with OKT3. Transplantation. 50: 608-612. PMID 2145669 DOI: 10.1097/00007890-199010000-00016  0.36
1989 Houlden BA, Matis LA, Cron RQ, Widacki SM, Brown GD, Pampeno C, Meruelo D, Bluestone JA. A TCRγδ cell recognizing a novel TL-encoded gene product Cold Spring Harbor Symposia On Quantitative Biology. 54: 45-55. PMID 2576978 DOI: 10.1101/Sqb.1989.054.01.006  1
1989 Bluestone JA, Potter T. T cell clones and monoclonal antibodies: immunologic probes of major histocompatibility complex class I molecules Chemical Immunology. 46: 23-48. PMID 2514705 DOI: 10.1159/000318822  1
1988 Ajitkumar P, Geier SS, Kesari KV, Borriello F, Nakagawa M, Bluestone JA, Saper MA, Wiley DC, Nathenson SG. Evidence that multiple residues on both the α-helices of the class I MHC molecule are simultaneously recognized by the T cell receptor Cell. 54: 47-56. PMID 3260136 DOI: 10.1016/0092-8674(88)90178-X  1
1988 Langlet C, Guimezanes A, Kaldy P, Boyer C, Buferne M, Poenie M, Tsien R, Leo O, Bluestone J, Leserman L. Role of Ti/CD3, Thy-1, and Ly-6 in cytolytic T-cell activation analyzed with Ti loss variants. Annals of the New York Academy of Sciences. 532: 33-43. PMID 2902820 DOI: 10.1111/J.1749-6632.1988.Tb36323.X  1
1987 Pardoll DM, Lew AM, Maloy WL, Fowlkes BJ, Kruisbeek A, Bluestone JA, Schwartz RH, Coligan JE. Analysis of T-cell receptor gamma chain expression in the thymus Advances in Experimental Medicine and Biology. 225: 241-246. PMID 3453602 DOI: 10.1007/978-1-4684-5442-0_21  1
1987 Bluestone JA, Pardoll D, Sharrow SO, Fowlkes BJ. Characterization of murine thymocytes with CDS-associated T-cell receptor structures Nature. 326: 82-84. PMID 3102972 DOI: 10.1038/326082A0  1
1987 Pardoll DM, Fowlkes BJ, Bluestone JA, Kruisbeek A, Maloy WL, Coligan JE, Schwartz RH. Differential expression of two distinct T-cell receptors during thymocyte development Nature. 326: 79-81. PMID 3102971 DOI: 10.1038/326079A0  1
1986 Lew AM, Pardoll DM, Maloy WL, Fowlkes BJ, Kruisbeek A, Cheng SF, Germain RN, Bluestone JA, Schwartz RH, Coligan JE. Characterization of T cell receptor gamma chain expression in a subset of murine thymocytes Science. 234: 1401-1405. PMID 3787252 DOI: 10.1126/Science.3787252  1
1986 Ildstad ST, Bluestone JA, Sachs DH. Alloresistance to engraftment of allogeneic donor bone marrow is mediated by an Lyt-2+ T cell in mixed allogeneic reconstitution (C57BL/10Sn + B10.D2/nSn → C57BL/10Sn) Journal of Experimental Medicine. 163: 1343-1348. PMID 2939173 DOI: 10.1084/Jem.163.5.1343  1
1985 Frels WI, Bluestone JA, Hodes RJ, Capecchi MR, Singer DS. Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. Science (New York, N.Y.). 228: 577-80. PMID 3885396 DOI: 10.1126/Science.3885396  1
1985 Ildstad ST, Wren SM, Bluestone JA, Barbieri SA, Sachs DH. Characterization of mixed allogeneic chimeras. Immunocompetence, in vitro reactivity, and genetic specificity of tolerance Journal of Experimental Medicine. 162: 231-244. PMID 3159825 DOI: 10.1084/Jem.162.1.231  1
1982 Bluestone JA, Metzger JJ, Knode MC, Ozato K, Sachs DH. Anti-idiotypes to monoclonal anti-H-2 antibodies-I. Contribution of isolated heavy and light chains to idiotype expression Molecular Immunology. 19: 515-524. PMID 6178014 DOI: 10.1016/0161-5890(82)90219-X  1
1981 Bluestone JA, Epstein SL, Ozato K, Sharrow SO, Sachs DH. Anti-idiotypes to monoclonal anti-H2 antibodies. II. Expression of anti-H-2K(k) idiotypes on antibodies induced by anti-idiotype or H-2K(k) antigen Journal of Experimental Medicine. 154: 1305-1318. PMID 7028910 DOI: 10.1084/Jem.154.5.1305  1
1981 Epstein SL, Ozato K, Bluestone JA, Sachs DH. Idiotypes of anti-Ia antibodies. I. Expression of the 14-4-4S idiotype in humoral immune responses Journal of Experimental Medicine. 154: 397-410. PMID 6790657 DOI: 10.1084/Jem.154.2.397  1
1981 Bluestone JA, Sharrow SO, Epstein SL, Ozato K, Sachs DH. Induction of anti-H-2 antibodies without alloantigen exposure by in vivo administration of anti-idiotype Nature. 291: 233-235. PMID 6785654 DOI: 10.1038/291233A0  1
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