Peter M. Glazer - Publications

Yale University, New Haven, CT 
Genetics, Cell Biology, Radiology

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Year Citation  Score
2020 Kaplan AR, Pham H, Liu Y, Oyaghire S, Bahal R, Engelman DM, Glazer PM. Ku80-targeted pH-sensitive peptide-PNA conjugates are tumor selective and sensitize cancer cells to ionizing radiation. Molecular Cancer Research : McR. PMID 32098827 DOI: 10.1158/1541-7786.MCR-19-0661  0.76
2020 Oyaghire SN, Quijano E, Piotrowski-Daspit AS, Saltzman WM, Glazer PM. Poly(Lactic-co-Glycolic Acid) Nanoparticle Delivery of Peptide Nucleic Acids In Vivo. Methods in Molecular Biology (Clifton, N.J.). 2105: 261-281. PMID 32088877 DOI: 10.1007/978-1-0716-0243-0_17  0.76
2020 Economos NG, Oyaghire S, Quijano E, Ricciardi AS, Saltzman WM, Glazer PM. Peptide Nucleic Acids and Gene Editing: Perspectives on Structure and Repair. Molecules (Basel, Switzerland). 25. PMID 32046275 DOI: 10.3390/molecules25030735  0.76
2019 Svoronos AA, Bahal R, Pereira MC, Barrera FN, Deacon JC, Bosenberg M, DiMaio D, Glazer PM, Engelman DM. Tumor-Targeted, Cytoplasmic Delivery of Large, Polar Molecules using a pH-Low Insertion Peptide. Molecular Pharmaceutics. PMID 31855437 DOI: 10.1021/acs.molpharmaceut.9b00883  0.52
2019 Sahraei M, Chaube B, Liu Y, Sun J, Kaplan A, Price NL, Ding W, Oyaghire S, García-Milian R, Mehta S, Reshetnyak YK, Bahal R, Fiorina P, Glazer PM, Rimm DL, et al. Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response. The Journal of Clinical Investigation. PMID 31710308 DOI: 10.1172/JCI127125  0.76
2019 Mandl HK, Quijano E, Suh HW, Sparago E, Oeck S, Grun M, Glazer PM, Saltzman WM. Optimizing biodegradable nanoparticle size for tissue-specific delivery. Journal of Controlled Release : Official Journal of the Controlled Release Society. 314: 92-101. PMID 31654688 DOI: 10.1016/j.jconrel.2019.09.020  0.76
2019 Kaplan AR, Gueble SE, Liu Y, Oeck S, Kim H, Yun Z, Glazer PM. Cediranib suppresses homology-directed DNA repair through down-regulation of BRCA1/2 and RAD51. Science Translational Medicine. 11. PMID 31092693 DOI: 10.1126/scitranslmed.aav4508  0.32
2019 Oeck S, Malewicz NM, Krysztofiak A, Turchick A, Jendrossek V, Glazer PM. High-throughput Evaluation of Protein Migration and Localization after Laser Micro-Irradiation. Scientific Reports. 9: 3148. PMID 30816253 DOI: 10.1038/s41598-019-39760-8  0.32
2018 Neel BG, Xu Y, Taylor P, Andrade J, Ueberheide B, Shuch B, Glazer PM, Bindra RS, Moran MF, Linehan WM. Pathological Oxidation of PTPN12 Underlies ABL1 Phosphorylation in Hereditary Leiomyomatosis and Renal Cell Carcinoma. Cancer Research. PMID 30297534 DOI: 10.1158/0008-5472.CAN-18-0901  0.84
2018 Sulkowski PL, Sundaram RK, Oeck S, Corso CD, Liu Y, Noorbakhsh S, Niger M, Boeke M, Ueno D, Kalathil AN, Bao X, Li J, Shuch B, Bindra RS, Glazer PM. Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair. Nature Genetics. PMID 30013182 DOI: 10.1038/s41588-018-0170-4  0.84
2018 Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, et al. In utero nanoparticle delivery for site-specific genome editing. Nature Communications. 9: 2481. PMID 29946143 DOI: 10.1038/s41467-018-04894-2  0.76
2018 Lu Y, Liu Y, Oeck S, Glazer PM. Hypoxia Promotes Resistance to EGFR Inhibition in NSCLC Cells via the Histone Demethylases, LSD1 and PLU-1. Molecular Cancer Research : McR. PMID 29934325 DOI: 10.1158/1541-7786.MCR-17-0637  0.44
2018 Sulkowski PL, Scanlon SE, Oeck S, Glazer PM. PTEN Regulates Non-Homologous End Joining by Epigenetic Induction of NHEJ1/XLF. Molecular Cancer Research : McR. PMID 29739874 DOI: 10.1158/1541-7786.MCR-17-0581  0.32
2018 Ricciardi AS, Quijano E, Putman R, Saltzman WM, Glazer PM. Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing. Molecules (Basel, Switzerland). 23. PMID 29534473 DOI: 10.3390/molecules23030632  0.76
2018 Scanlon SE, Hegan DC, Sulkowski PL, Glazer PM. Suppression of homology-dependent DNA double-strand break repair induces PARP inhibitor sensitivity in VHL-deficient human renal cell carcinoma. Oncotarget. 9: 4647-4660. PMID 29435132 DOI: 10.18632/oncotarget.23470  0.44
2017 Quijano E, Bahal R, Ricciardi A, Saltzman WM, Glazer PM. 
Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities
. The Yale Journal of Biology and Medicine. 90: 583-598. PMID 29259523  0.76
2017 Gupta A, Quijano E, Liu Y, Bahal R, Scanlon SE, Song E, Hsieh WC, Braddock DE, Ly DH, Saltzman WM, Glazer PM. Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy. Molecular Therapy. Nucleic Acids. 9: 111-119. PMID 29246289 DOI: 10.1016/j.omtn.2017.09.001  0.76
2017 Turchick A, Hegan DC, Jensen RB, Glazer PM. A cell-penetrating antibody inhibits human RAD51 via direct binding. Nucleic Acids Research. PMID 29036688 DOI: 10.1093/nar/gkx871  0.44
2017 Scanlon SE, Scanlon CD, Hegan DC, Sulkowski PL, Glazer PM. Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells. Carcinogenesis. PMID 28472268 DOI: 10.1093/carcin/bgx038  0.44
2017 Sulkowski PL, Corso CD, Robinson ND, Scanlon SE, Purshouse KR, Bai H, Liu Y, Sundaram RK, Hegan DC, Fons NR, Breuer GA, Song Y, Mishra-Gorur K, De Feyter HM, de Graaf RA, ... ... Glazer PM, et al. 2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. Science Translational Medicine. 9. PMID 28148839 DOI: 10.1126/scitranslmed.aal2463  0.84
2016 Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, ... ... Glazer PM, et al. In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Nature Communications. 7: 13304. PMID 27782131 DOI: 10.1038/ncomms13304  0.76
2016 Gupta A, Bahal R, Gupta M, Glazer PM, Saltzman WM. Nanotechnology for delivery of peptide nucleic acids (PNAs). Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 26776051 DOI: 10.1016/j.jconrel.2016.01.005  1
2015 Stachelek GC, Peterson-Roth E, Liu Y, Fernandez RJ, Pike LR, Qian JM, Abriola L, Hoyer D, Hungerford W, Merkel J, Glazer PM. YU238259 is a Novel Inhibitor of Homology-dependent DNA Repair that Exhibits Synthetic Lethality and Radiosensitization in Repair-deficient Tumors. Molecular Cancer Research : McR. PMID 26116172 DOI: 10.1158/1541-7786.MCR-15-0036  0.44
2015 Yun Z, Glazer PM. Tumor suppressor p53 stole the AKT in hypoxia Journal of Clinical Investigation. 125: 2264-2266. PMID 25961449 DOI: 10.1172/JCI82058  1
2015 McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME. Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium. Nature Communications. 6: 6952. PMID 25914116 DOI: 10.1038/ncomms7952  0.4
2015 Colis LC, Hegan DC, Kaneko M, Glazer PM, Herzon SB. Mechanism of action studies of lomaiviticin a and the monomeric lomaiviticin aglycon. Selective and potent activity toward DNA double-strand break repair-deficient cell lines. Journal of the American Chemical Society. 137: 5741-7. PMID 25849366 DOI: 10.1021/ja513117p  1
2015 Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ. MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature. 518: 107-10. PMID 25409146 DOI: 10.1038/nature13905  0.4
2015 Reza F, Glazer PM. Therapeutic genome mutagenesis using synthetic donor DNA and triplex-forming molecules. Methods in Molecular Biology (Clifton, N.J.). 1239: 39-73. PMID 25408401 DOI: 10.1007/978-1-4939-1862-1_4  1
2015 Fields RJ, Quijano E, McNeer NA, Caputo C, Bahal R, Anandalingam K, Egan ME, Glazer PM, Saltzman WM. Modified poly(lactic-co-glycolic acid) nanoparticles for enhanced cellular uptake and gene editing in the lung. Advanced Healthcare Materials. 4: 361-6. PMID 25156908 DOI: 10.1002/adhm.201400355  0.4
2014 Bahal R, Quijano E, McNeer NA, Liu Y, Bhunia DC, Lopez-Giraldez F, Fields RJ, Saltzman WM, Ly DH, Glazer PM. Single-stranded γPNAs for in vivo site-specific genome editing via Watson-Crick recognition. Current Gene Therapy. 14: 331-42. PMID 25174576  1
2014 Lu Y, Wajapeyee N, Turker MS, Glazer PM. Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1. Cell Reports. 8: 501-13. PMID 25043185 DOI: 10.1016/j.celrep.2014.06.035  0.44
2014 Ricciardi AS, McNeer NA, Anandalingam KK, Saltzman WM, Glazer PM. Targeted genome modification via triple helix formation. Methods in Molecular Biology (Clifton, N.J.). 1176: 89-106. PMID 25030921 DOI: 10.1007/978-1-4939-0992-6_8  1
2014 Zhang M, Xiang S, Joo HY, Wang L, Williams KA, Liu W, Hu C, Tong D, Haakenson J, Wang C, Zhang S, Pavlovicz RE, Jones A, Schmidt KH, Tang J, ... ... Glazer PM, et al. HDAC6 deacetylates and ubiquitinates MSH2 to maintain proper levels of MutSα. Molecular Cell. 55: 31-46. PMID 24882211 DOI: 10.1016/j.molcel.2014.04.028  1
2014 Colis LC, Woo CM, Hegan DC, Li Z, Glazer PM, Herzon SB. The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA. Nature Chemistry. 6: 504-10. PMID 24848236 DOI: 10.1038/nchem.1944  1
2014 Kidane D, Chae WJ, Czochor J, Eckert KA, Glazer PM, Bothwell AL, Sweasy JB. Interplay between DNA repair and inflammation, and the link to cancer. Critical Reviews in Biochemistry and Molecular Biology. 49: 116-39. PMID 24410153 DOI: 10.3109/10409238.2013.875514  1
2014 Schleifman EB, Glazer PM. Peptide nucleic acid-mediated recombination for targeted genomic repair and modification. Methods in Molecular Biology (Clifton, N.J.). 1050: 207-22. PMID 24297362 DOI: 10.1007/978-1-62703-553-8_17  0.92
2013 Glazer PM, Hegan DC, Lu Y, Czochor J, Scanlon SE. Hypoxia and DNA repair. The Yale Journal of Biology and Medicine. 86: 443-51. PMID 24348208  0.44
2013 Schleifman EB, McNeer NA, Jackson A, Yamtich J, Brehm MA, Shultz LD, Greiner DL, Kumar P, Saltzman WM, Glazer PM. Site-specific Genome Editing in PBMCs With PLGA Nanoparticle-delivered PNAs Confers HIV-1 Resistance in Humanized Mice. Molecular Therapy. Nucleic Acids. 2: e135. PMID 24253260 DOI: 10.1038/mtna.2013.59  0.92
2013 Bahal R, McNeer NA, Ly DH, Saltzman WM, Glazer PM. Nanoparticle for delivery of antisense γPNA oligomers targeting CCR5. Artificial Dna, Pna & Xna. 4: 49-57. PMID 23954968 DOI: 10.4161/adna.25628  1
2013 Shahbazian D, Bindra RS, Kluger HM, Glazer PM. Radiation sensitivity and sensitization in melanoma. Pigment Cell & Melanoma Research. 26: 928-30. PMID 23870422 DOI: 10.1111/pcmr.12147  0.84
2013 Chin JY, Reza F, Glazer PM. Triplex-forming peptide nucleic acids induce heritable elevations in gamma-globin expression in hematopoietic progenitor cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 580-7. PMID 23337982 DOI: 10.1038/mt.2012.262  0.96
2013 McNeer NA, Schleifman EB, Cuthbert A, Brehm M, Jackson A, Cheng C, Anandalingam K, Kumar P, Shultz LD, Greiner DL, Mark Saltzman W, Glazer PM. Systemic delivery of triplex-forming PNA and donor DNA by nanoparticles mediates site-specific genome editing of human hematopoietic cells in vivo. Gene Therapy. 20: 658-69. PMID 23076379 DOI: 10.1038/gt.2012.82  1
2012 Hansen JE, Chan G, Liu Y, Hegan DC, Dalal S, Dray E, Kwon Y, Xu Y, Xu X, Peterson-Roth E, Geiger E, Liu Y, Gera J, Sweasy JB, Sung P, ... ... Glazer PM, et al. Targeting cancer with a lupus autoantibody. Science Translational Medicine. 4: 157ra142. PMID 23100628 DOI: 10.1126/scitranslmed.3004385  0.68
2012 Meng F, Evans JW, Bhupathi D, Banica M, Lan L, Lorente G, Duan JX, Cai X, Mowday AM, Guise CP, Maroz A, Anderson RF, Patterson AV, Stachelek GC, Glazer PM, et al. Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302. Molecular Cancer Therapeutics. 11: 740-51. PMID 22147748 DOI: 10.1158/1535-7163.MCT-11-0634  0.44
2012 Rockwell S, Liu Y, Seow HA, Ishiguro K, Baumann RP, Penketh PG, Shyam K, Akintujoye OM, Glazer PM, Sartorelli AC. Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors. International Journal of Radiation Biology. 88: 277-85. PMID 22111842 DOI: 10.3109/09553002.2012.638359  0.68
2012 Rogers FA, Lin SS, Hegan DC, Krause DS, Glazer PM. Targeted gene modification of hematopoietic progenitor cells in mice following systemic administration of a PNA-peptide conjugate. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 109-18. PMID 21829173 DOI: 10.1038/mt.2011.163  0.56
2011 Schleifman EB, Bindra R, Leif J, del Campo J, Rogers FA, Uchil P, Kutsch O, Shultz LD, Kumar P, Greiner DL, Glazer PM. Targeted disruption of the CCR5 gene in human hematopoietic stem cells stimulated by peptide nucleic acids. Chemistry & Biology. 18: 1189-98. PMID 21944757 DOI: 10.1016/j.chembiol.2011.07.010  0.92
2011 Glazer PM, Le QT, Bristow R, Helleday T, Pelroy R, Bernhard EJ. New translational possibilities for microenvironmental modulation of radiosensitivity Radiation Research. 176: 412-414. PMID 21867431 DOI: 10.1667/RRXX33.1  1
2011 Glazer PM, Grandis J, Powell SN, Brown JM, Helleday T, Bristow R, Powis G, Hill RP, Le QT, Pelroy R, Mohla S, Bernhard EJ. Radiation Resistance in Cancer Therapy: meeting summary and research opportunities. Report of an NCI Workshop held September 1-3, 2010. Radiation Research. 176: e0016-21. PMID 21867428 DOI: 10.1667/RROL02.1  1
2011 Lu Y, Chu A, Turker MS, Glazer PM. Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter. Molecular and Cellular Biology. 31: 3339-50. PMID 21670155 DOI: 10.1128/MCB.01121-10  0.44
2011 McNeer NA, Schleifman EB, Glazer PM, Saltzman WM. Polymer delivery systems for site-specific genome editing. Journal of Controlled Release : Official Journal of the Controlled Release Society. 155: 312-6. PMID 21620910 DOI: 10.1016/j.jconrel.2011.05.011  1
2011 McNeer NA, Chin JY, Schleifman EB, Fields RJ, Glazer PM, Saltzman WM. Nanoparticles deliver triplex-forming PNAs for site-specific genomic recombination in CD34+ human hematopoietic progenitors. Molecular Therapy : the Journal of the American Society of Gene Therapy. 19: 172-80. PMID 20859257 DOI: 10.1038/mt.2010.200  1
2010 Klein TJ, Glazer PM. The tumor microenvironment and DNA repair. Seminars in Radiation Oncology. 20: 282-7. PMID 20832021 DOI: 10.1016/j.semradonc.2010.05.006  1
2010 Hegan DC, Lu Y, Stachelek GC, Crosby ME, Bindra RS, Glazer PM. Inhibition of poly(ADP-ribose) polymerase down-regulates BRCA1 and RAD51 in a pathway mediated by E2F4 and p130. Proceedings of the National Academy of Sciences of the United States of America. 107: 2201-6. PMID 20133863 DOI: 10.1073/pnas.0904783107  0.84
2010 Stachelek GC, Dalal S, Donigan KA, Campisi Hegan D, Sweasy JB, Glazer PM. Potentiation of temozolomide cytotoxicity by inhibition of DNA polymerase beta is accentuated by BRCA2 mutation. Cancer Research. 70: 409-17. PMID 20028873 DOI: 10.1158/0008-5472.CAN-09-1353  0.44
2009 Crosby ME, Glazer PM, Ivan M. "Micro"-management of DNA repair genes by hypoxia Cell Cycle. 8: 4009-4010. PMID 19949295  1
2009 Crosby ME, Devlin CM, Glazer PM, Calin GA, Ivan M. Emerging roles of microRNAs in the molecular responses to hypoxia Current Pharmaceutical Design. 15: 3861-3866. PMID 19925433 DOI: 10.2174/138161209789649367  1
2009 Glazer PM, Bindra RS. Introduction: the evolving picture of the hypoxic tumour microenvironment. Current Molecular Medicine. 9: 399-400. PMID 19519396  0.84
2009 Lonkar P, Kim KH, Kuan JY, Chin JY, Rogers FA, Knauert MP, Kole R, Nielsen PE, Glazer PM. Targeted correction of a thalassemia-associated beta-globin mutation induced by pseudo-complementary peptide nucleic acids. Nucleic Acids Research. 37: 3635-44. PMID 19364810 DOI: 10.1093/nar/gkp217  1
2009 Crosby ME, Kulshreshtha R, Ivan M, Glazer PM. MicroRNA regulation of DNA repair gene expression in hypoxic stress Cancer Research. 69: 1221-1229. PMID 19141645 DOI: 10.1158/0008-5472.CAN-08-2516  1
2009 Chin JY, Glazer PM. Repair of DNA lesions associated with triplex-forming oligonucleotides. Molecular Carcinogenesis. 48: 389-99. PMID 19072762 DOI: 10.1002/mc.20501  1
2008 Chin JY, Kuan JY, Lonkar PS, Krause DS, Seidman MM, Peterson KR, Nielsen PE, Kole R, Glazer PM. Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids. Proceedings of the National Academy of Sciences of the United States of America. 105: 13514-9. PMID 18757759 DOI: 10.1073/pnas.0711793105  1
2008 Schleifman EB, Chin JY, Glazer PM. Triplex-mediated gene modification. Methods in Molecular Biology (Clifton, N.J.). 435: 175-90. PMID 18370076 DOI: 10.1007/978-1-59745-232-8_13  1
2008 Chan N, Koritzinsky M, Zhao H, Bindra R, Glazer PM, Powell S, Belmaaza A, Wouters B, Bristow RG. Chronic hypoxia decreases synthesis of homologous recombination proteins to offset chemoresistance and radioresistance. Cancer Research. 68: 605-14. PMID 18199558 DOI: 10.1158/0008-5472.CAN-07-5472  1
2007 Kim KH, Nielsen PE, Glazer PM. Site-directed gene mutation at mixed sequence targets by psoralen-conjugated pseudo-complementary peptide nucleic acids. Nucleic Acids Research. 35: 7604-13. PMID 17977869 DOI: 10.1093/nar/gkm666  0.56
2007 Chin JY, Schleifman EB, Glazer PM. Repair and recombination induced by triple helix DNA. Frontiers in Bioscience : a Journal and Virtual Library. 12: 4288-97. PMID 17485375 DOI: 10.2741/2388  1
2007 Bindra RS, Crosby ME, Glazer PM. Regulation of DNA repair in hypoxic cancer cells Cancer and Metastasis Reviews. 26: 249-260. PMID 17415527 DOI: 10.1007/s10555-007-9061-3  1
2007 Bindra RS, Glazer PM. Co-repression of mismatch repair gene expression by hypoxia in cancer cells: role of the Myc/Max network. Cancer Letters. 252: 93-103. PMID 17275176 DOI: 10.1016/j.canlet.2006.12.011  0.84
2007 Huang LE, Bindra RS, Glazer PM, Harris AL. Hypoxia-induced genetic instability--a calculated mechanism underlying tumor progression. Journal of Molecular Medicine (Berlin, Germany). 85: 139-48. PMID 17180667 DOI: 10.1007/s00109-006-0133-6  0.84
2007 Bindra RS, Glazer PM. Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia. Oncogene. 26: 2048-57. PMID 17001309 DOI: 10.1038/sj.onc.1210001  0.84
2006 Bindra RS, Glazer PM. Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites. Cancer Biology & Therapy. 5: 1400-7. PMID 17106239  0.84
2006 Gibson SL, Bindra RS, Glazer PM. CHK2-dependent phosphorylation of BRCA1 in hypoxia. Radiation Research. 166: 646-51. PMID 17007555 DOI: 10.1667/RR0660.1  1
2006 Knauert MP, Kalish JM, Hegan DC, Glazer PM. Triplex-stimulated intermolecular recombination at a single-copy genomic target. Molecular Therapy : the Journal of the American Society of Gene Therapy. 14: 392-400. PMID 16731047 DOI: 10.1016/j.ymthe.2006.03.020  1
2006 Hegan DC, Narayanan L, Jirik FR, Edelmann W, Liskay RM, Glazer PM. Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Carcinogenesis. 27: 2402-8. PMID 16728433 DOI: 10.1093/carcin/bgl079  1
2006 Shahid KA, Majumdar A, Alam R, Liu ST, Kuan JY, Sui X, Cuenoud B, Glazer PM, Miller PS, Seidman MM. Targeted cross-linking of the human beta-globin gene in living cells mediated by a triple helix forming oligonucleotide. Biochemistry. 45: 1970-8. PMID 16460044 DOI: 10.1021/bi0520986  1
2006 Smith-Roe SL, Löhr CV, Bildfell RJ, Fischer KA, Hegan DC, Glazer PM, Buermeyer AB. Induction of aberrant crypt foci in DNA mismatch repair-deficient mice by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP). Cancer Letters. 244: 79-85. PMID 16427736 DOI: 10.1016/j.canlet.2005.12.002  0.44
2006 Gibson SL, Narayanan L, Hegan DC, Buermeyer AB, Liskay RM, Glazer PM. Overexpression of the DNA mismatch repair factor, PMS2, confers hypermutability and DNA damage tolerance. Cancer Letters. 244: 195-202. PMID 16426742 DOI: 10.1016/j.canlet.2005.12.009  1
2006 Kim KH, Nielsen PE, Glazer PM. Site-specific gene modification by PNAs conjugated to psoralen. Biochemistry. 45: 314-23. PMID 16388608 DOI: 10.1021/bi051379a  0.56
2006 Smith-Roe SL, Hegan DC, Glazer PM, Buermeyer AB. Mlh1-dependent suppression of specific mutations induced in vivo by the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP). Mutation Research. 594: 101-12. PMID 16256150 DOI: 10.1016/j.mrfmmm.2005.08.011  0.44
2005 Kalish JM, Glazer PM. Targeted genome modification via triple helix formation. Annals of the New York Academy of Sciences. 1058: 151-61. PMID 16394134 DOI: 10.1196/annals.1359.023  0.44
2005 Bindra RS, Schaffer PJ, Meng A, Woo J, Måseide K, Roth ME, Lizardi P, Hedley DW, Bristow RG, Glazer PM. Alterations in DNA repair gene expression under hypoxia: elucidating the mechanisms of hypoxia-induced genetic instability. Annals of the New York Academy of Sciences. 1059: 184-95. PMID 16382054 DOI: 10.1196/annals.1339.049  1
2005 Bindra RS, Gibson SL, Meng A, Westermark U, Jasin M, Pierce AJ, Bristow RG, Classon MK, Glazer PM. Hypoxia-induced down-regulation of BRCA1 expression by E2Fs. Cancer Research. 65: 11597-604. PMID 16357170 DOI: 10.1158/0008-5472.CAN-05-2119  1
2005 Gibson SL, Bindra RS, Glazer PM. Hypoxia-induced phosphorylation of Chk2 in an ataxia telangiectasia mutated-dependent manner. Cancer Research. 65: 10734-41. PMID 16322218 DOI: 10.1158/0008-5472.CAN-05-1160  1
2005 Lewin AS, Glazer PM, Milstone LM. Gene therapy for autosomal dominant disorders of keratin. The Journal of Investigative Dermatology. Symposium Proceedings / the Society For Investigative Dermatology, Inc. [and] European Society For Dermatological Research. 10: 47-61. PMID 16250209 DOI: 10.1111/j.1087-0024.2005.10207.x  1
2005 Rogers FA, Lloyd JA, Glazer PM. Triplex-forming oligonucleotides as potential tools for modulation of gene expression. Current Medicinal Chemistry. Anti-Cancer Agents. 5: 319-26. PMID 16101484  0.56
2005 Meng AX, Jalali F, Cuddihy A, Chan N, Bindra RS, Glazer PM, Bristow RG. Hypoxia down-regulates DNA double strand break repair gene expression in prostate cancer cells. Radiotherapy and Oncology : Journal of the European Society For Therapeutic Radiology and Oncology. 76: 168-76. PMID 16026872 DOI: 10.1016/j.radonc.2005.06.025  1
2005 Kalish JM, Seidman MM, Weeks DL, Glazer PM. Triplex-induced recombination and repair in the pyrimidine motif. Nucleic Acids Research. 33: 3492-502. PMID 15961731 DOI: 10.1093/nar/gki659  0.44
2005 Knauert MP, Lloyd JA, Rogers FA, Datta HJ, Bennett ML, Weeks DL, Glazer PM. Distance and affinity dependence of triplex-induced recombination. Biochemistry. 44: 3856-64. PMID 15751961 DOI: 10.1021/bi0481040  1
2005 Bindra RS, Glazer PM. Genetic instability and the tumor microenvironment: towards the concept of microenvironment-induced mutagenesis. Mutation Research. 569: 75-85. PMID 15603753 DOI: 10.1016/j.mrfmmm.2004.03.013  0.84
2004 Rogers FA, Manoharan M, Rabinovitch P, Ward DC, Glazer PM. Peptide conjugates for chromosomal gene targeting by triplex-forming oligonucleotides. Nucleic Acids Research. 32: 6595-604. PMID 15602001 DOI: 10.1093/nar/gkh998  1
2004 Bindra RS, Schaffer PJ, Meng A, Woo J, Måseide K, Roth ME, Lizardi P, Hedley DW, Bristow RG, Glazer PM. Down-regulation of Rad51 and decreased homologous recombination in hypoxic cancer cells. Molecular and Cellular Biology. 24: 8504-18. PMID 15367671 DOI: 10.1128/MCB.24.19.8504-8518.2004  1
2004 Kuan JY, Glazer PM. Targeted gene modification using triplex-forming oligonucleotides. Methods in Molecular Biology (Clifton, N.J.). 262: 173-94. PMID 14769962 DOI: 10.1385/1-59259-761-0:173  1
2003 Mihaylova VT, Bindra RS, Yuan J, Campisi D, Narayanan L, Jensen R, Giordano F, Johnson RS, Rockwell S, Glazer PM. Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells. Molecular and Cellular Biology. 23: 3265-73. PMID 12697826 DOI: 10.1128/MCB.23.9.3265-3273.2003  1
2003 Macris MA, Glazer PM. Transcription dependence of chromosomal gene targeting by triplex-forming oligonucleotides. The Journal of Biological Chemistry. 278: 3357-62. PMID 12431993 DOI: 10.1074/jbc.M206542200  0.76
2002 Rogers FA, Vasquez KM, Egholm M, Glazer PM. Site-directed recombination via bifunctional PNA-DNA conjugates. Proceedings of the National Academy of Sciences of the United States of America. 99: 16695-700. PMID 12461167 DOI: 10.1073/pnas.262556899  1
2002 Peretz S, Kim C, Rockwell S, Baserga R, Glazer PM. IGF1 receptor expression protects against microenvironmental stress found in the solid tumor. Radiation Research. 158: 174-80. PMID 12105987  1
2002 Vasquez KM, Glazer PM. Triplex-forming oligonucleotides: principles and applications. Quarterly Reviews of Biophysics. 35: 89-107. PMID 11997982 DOI: 10.1017/S0033583502003773  1
2002 Vasquez KM, Christensen J, Li L, Finch RA, Glazer PM. Human XPA and RPA DNA repair proteins participate in specific recognition of triplex-induced helical distortions. Proceedings of the National Academy of Sciences of the United States of America. 99: 5848-53. PMID 11972036 DOI: 10.1073/pnas.082193799  1
2001 Rockwell S, Yuan J, Peretz S, Glazer PM. Genomic instability in cancer. Novartis Foundation Symposium. 240: 133-42; discussion 1. PMID 11727926  1
2001 Knauert MP, Glazer PM. Triplex forming oligonucleotides: sequence-specific tools for gene targeting. Human Molecular Genetics. 10: 2243-51. PMID 11673407  1
2001 Datta HJ, Chan PP, Vasquez KM, Gupta RC, Glazer PM. Triplex-induced recombination in human cell-free extracts. Dependence on XPA and HsRad51. The Journal of Biological Chemistry. 276: 18018-23. PMID 11278954 DOI: 10.1074/jbc.M011646200  1
2001 Peretz S, Jensen R, Baserga R, Glazer PM. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proceedings of the National Academy of Sciences of the United States of America. 98: 1676-81. PMID 11172010 DOI: 10.1073/pnas.041416598  0.68
2000 Yuan J, Narayanan L, Rockwell S, Glazer PM. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Research. 60: 4372-6. PMID 10969780  1
2000 Luo Z, Macris MA, Faruqi AF, Glazer PM. High-frequency intrachromosomal gene conversion induced by triplex-forming oligonucleotides microinjected into mouse cells. Proceedings of the National Academy of Sciences of the United States of America. 97: 9003-8. PMID 10900269 DOI: 10.1073/pnas.160004997  0.76
1999 Chan PP, Lin M, Faruqi AF, Powell J, Seidman MM, Glazer PM. Targeted correction of an episomal gene in mammalian cells by a short DNA fragment tethered to a triplex-forming oligonucleotide. The Journal of Biological Chemistry. 274: 11541-8. PMID 10206960  0.64
1998 Yuan J, Glazer PM. Mutagenesis induced by the tumor microenvironment. Mutation Research. 400: 439-46. PMID 9685702  1
1997 Turner BC, Haffty BG, Narayanan L, Yuan J, Havre PA, Gumbs AA, Kaplan L, Burgaud JL, Carter D, Baserga R, Glazer PM. Insulin-like growth factor-I receptor overexpression mediates cellular radioresistance and local breast cancer recurrence after lumpectomy and radiation. Cancer Research. 57: 3079-83. PMID 9242428  1
1997 Chan PP, Glazer PM. Triplex DNA: fundamentals, advances, and potential applications for gene therapy. Journal of Molecular Medicine (Berlin, Germany). 75: 267-82. PMID 9151213  0.64
1995 Yuan J, Yeasky TM, Rhee MC, Glazer PM. Frequent T:A-->G:C transversions in X-irradiated mouse cells. Carcinogenesis. 16: 83-8. PMID 7834808  1
1995 Havre PA, Yuan J, Hedrick L, Cho KR, Glazer PM. p53 inactivation by HPV16 E6 results in increased mutagenesis in human cells. Cancer Research. 55: 4420-4. PMID 7671255  1
1995 Yuan J, Yeasky TM, Havre PA, Glazer PM. Induction of p53 in mouse cells decreases mutagenesis by UV radiation. Carcinogenesis. 16: 2295-300. PMID 7586125  1
Low-probability matches
2004 Seidman MM, Glazer PM. Setting standards in gene repair. Oligonucleotides. 14: 79. PMID 15294071 DOI: 10.1089/1545457041526263  0.28
2003 Seidman MM, Glazer PM. The potential for gene repair via triple helix formation. The Journal of Clinical Investigation. 112: 487-94. PMID 12925687 DOI: 10.1172/JCI19552  0.28
2014 Reza F, Glazer PM. Triplex-mediated genome targeting and editing. Methods in Molecular Biology (Clifton, N.J.). 1114: 115-42. PMID 24557900 DOI: 10.1007/978-1-62703-761-7_8  0.24
2012 Neumeister VM, Sullivan CA, Lindner R, Lezon-Geyda K, Li J, Zavada J, Martel M, Glazer PM, Tuck DP, Rimm DL, Harris L. Hypoxia-induced protein CAIX is associated with somatic loss of BRCA1 protein and pathway activity in triple negative breast cancer. Breast Cancer Research and Treatment. 136: 67-75. PMID 22976806 DOI: 10.1007/s10549-012-2232-0  0.24
2019 Turchick A, Liu Y, Zhao W, Cohen I, Glazer PM. Synthetic lethality of a cell-penetrating anti-RAD51 antibody in PTEN-deficient melanoma and glioma cells. Oncotarget. 10: 1272-1283. PMID 30863489 DOI: 10.18632/oncotarget.26654  0.2
2018 Wen Z, Peng J, Tuttle PR, Ren Y, Garcia C, Debnath D, Rishi S, Hanson C, Ward S, Kumar A, Liu Y, Zhao W, Glazer PM, Liu Y, Sevilla MD, et al. Electron-Mediated Aminyl and Iminyl Radicals from C5 Azido-Modified Pyrimidine Nucleosides Augment Radiation Damage to Cancer Cells. Organic Letters. PMID 30457873 DOI: 10.1021/acs.orglett.8b03035  0.2
2015 Weisbart RH, Chan G, Jordaan G, Noble PW, Liu Y, Glazer PM, Nishimura RN, Hansen JE. DNA-dependent targeting of cell nuclei by a lupus autoantibody. Scientific Reports. 5: 12022. PMID 26156563 DOI: 10.1038/srep12022  0.2
2004 Jensen R, Glazer PM. Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions. Proceedings of the National Academy of Sciences of the United States of America. 101: 6134-9. PMID 15069205 DOI: 10.1073/pnas.0400051101  0.2
2011 Babar IA, Czochor J, Steinmetz A, Weidhaas JB, Glazer PM, Slack FJ. Inhibition of hypoxia-induced miR-155 radiosensitizes hypoxic lung cancer cells. Cancer Biology & Therapy. 12: 908-14. PMID 22027557 DOI: 10.4161/cbt.12.10.17681  0.16
2002 Haffty BG, Harrold E, Khan AJ, Pathare P, Smith TE, Turner BC, Glazer PM, Ward B, Carter D, Matloff E, Bale AE, Alvarez-Franco M. Outcome of conservatively managed early-onset breast cancer by BRCA1/2 status. Lancet (London, England). 359: 1471-7. PMID 11988246 DOI: 10.1016/S0140-6736(02)08434-9  0.12
2015 Gupta R, Liu AY, Glazer PM, Wajapeyee N. LKB1 preserves genome integrity by stimulating BRCA1 expression. Nucleic Acids Research. 43: 259-71. PMID 25488815 DOI: 10.1093/nar/gku1294  0.08
2011 Lin ZP, Lee Y, Lin F, Belcourt MF, Li P, Cory JG, Glazer PM, Sartorelli AC. Reduced level of ribonucleotide reductase R2 subunits increases dependence on homologous recombination repair of cisplatin-induced DNA damage. Molecular Pharmacology. 80: 1000-12. PMID 21875941 DOI: 10.1124/mol.111.074708  0.08
2006 Zheng H, Wang X, Legerski RJ, Glazer PM, Li L. Repair of DNA interstrand cross-links: interactions between homology-dependent and homology-independent pathways. Dna Repair. 5: 566-74. PMID 16569514 DOI: 10.1016/j.dnarep.2006.01.010  0.08
2018 Kim H, Lin Q, Glazer PM, Yun Z. The hypoxic tumor microenvironment in vivo selects the cancer stem cell fate of breast cancer cells. Breast Cancer Research : Bcr. 20: 16. PMID 29510720 DOI: 10.1186/s13058-018-0944-8  0.04
2011 Glazer PM, Grandis J, Powell SN, Brown JM, Helleday T, Bristow R, Powis G, Hill RP, Le QT, Pelroy R, Mohla S, Bernhard EJ. Radiation Resistance in Cancer Therapy: Meeting Summary and Research Opportunities: Report of an NCI Workshop held September 1-3, 2010. Radiation Research. PMID 21740251 DOI: 10.1667/RROL02.1  0.04
2003 Haffty BG, Glazer PM. Molecular markers in clinical radiation oncology. Oncogene. 22: 5915-25. PMID 12947398 DOI: 10.1038/sj.onc.1206704  0.04
2019 Kaplan AR, Glazer PM. Impact of hypoxia on DNA repair and genome integrity. Mutagenesis. PMID 31282537 DOI: 10.1093/mutage/gez019  0.01
2017 Nemec AA, Abriola L, Merkel JS, deStanchina E, DeVeaux M, Zelterman D, Glazer PM, Sweasy JB. DNA polymerase beta germline variant confers cellular response to cisplatin therapy. Molecular Cancer Research : McR. PMID 28074003 DOI: 10.1158/1541-7786.MCR-16-0227-T  0.01
2016 Czochor JR, Sulkowski P, Glazer PM. miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair. Molecular Cancer Research : McR. 14: 363-73. PMID 26850462 DOI: 10.1158/1541-7786.MCR-15-0399  0.01
2015 Scanlon SE, Glazer PM. Multifaceted control of DNA repair pathways by the hypoxic tumor microenvironment. Dna Repair. 32: 180-9. PMID 25956861 DOI: 10.1016/j.dnarep.2015.04.030  0.01
2014 Scanlon SE, Glazer PM. Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins. Molecular Cancer Research : McR. 12: 1016-28. PMID 24688021 DOI: 10.1158/1541-7786.MCR-13-0628  0.01
2014 Czochor JR, Glazer PM. microRNAs in cancer cell response to ionizing radiation. Antioxidants & Redox Signaling. 21: 293-312. PMID 24206455 DOI: 10.1089/ars.2013.5718  0.01
2013 Sweasy JB, Glazer PM. Introduction. The Yale Journal of Biology and Medicine. 86: 441-2. PMID 24498669  0.01
2011 Williams SA, Wilson JB, Clark AP, Mitson-Salazar A, Tomashevski A, Ananth S, Glazer PM, Semmes OJ, Bale AE, Jones NJ, Kupfer GM. Functional and physical interaction between the mismatch repair and FA-BRCA pathways. Human Molecular Genetics. 20: 4395-410. PMID 21865299 DOI: 10.1093/hmg/ddr366  0.01
2010 Rowe BP, Glazer PM. Emergence of rationally designed therapeutic strategies for breast cancer targeting DNA repair mechanisms. Breast Cancer Research : Bcr. 12: 203. PMID 20459590 DOI: 10.1186/bcr2566  0.01
2009 Kim Y, Lin Q, Glazer PM, Yun Z. Hypoxic tumor microenvironment and cancer cell differentiation. Current Molecular Medicine. 9: 425-34. PMID 19519400  0.01
2009 Peterson-Roth E, Brdlik CM, Glazer PM. Src-Induced cisplatin resistance mediated by cell-to-cell communication. Cancer Research. 69: 3619-24. PMID 19351863 DOI: 10.1158/0008-5472.CAN-08-0985  0.01
2008 Marek LR, Kottemann MC, Glazer PM, Bale AE. MEN1 and FANCD2 mediate distinct mechanisms of DNA crosslink repair. Dna Repair. 7: 476-86. PMID 18258493 DOI: 10.1016/j.dnarep.2007.12.009  0.01
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