| Year |
Citation |
Score |
| 2022 |
Chen FW, Davies JP, Calvo R, Chaudhari J, Dolios G, Taylor MK, Patnaik S, Dehdashti J, Mull R, Dranchack P, Wang A, Xu X, Hughes E, Southall N, Ferrer M, ... ... Ioannou YA, et al. Activation of mitochondrial TRAP1 stimulates mitochondria-lysosome crosstalk and correction of lysosomal dysfunction. Iscience. 25: 104941. PMID 36065186 DOI: 10.1016/j.isci.2022.104941 |
0.544 |
|
| 2019 |
Robinson G, Radziszewska A, Wincup C, Ciurtin C, Ioannou Y, Torra IP, Jury E, Lab J. Op0148 Metabolomics In Juvenile-Onset Sle: Identifying New Biomarkers To Predict Cardiovascular Risk Annals of the Rheumatic Diseases. 78: 149-150. DOI: 10.1136/Annrheumdis-2019-Eular.4067 |
0.323 |
|
| 2018 |
Wincup C, Ioannou Y. The Differences Between Childhood and Adult Onset Antiphospholipid Syndrome. Frontiers in Pediatrics. 6: 362. PMID 30542645 DOI: 10.3389/Fped.2018.00362 |
0.303 |
|
| 2018 |
McDonnell TCR, Willis R, Pericleous C, Ripoll VM, Giles IP, Isenberg DA, Brasier AR, Gonzalez EB, Papalardo E, Romay-Penabad Z, Jamaluddin M, Ioannou Y, Rahman A. PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome. Frontiers in Immunology. 9: 2413. PMID 30405613 DOI: 10.3389/Fimmu.2018.02413 |
0.331 |
|
| 2018 |
Robinson G, Pineda-Torra I, Ioannou Y, Jury E. PS5:87 Juvenile-onset sle immunopathogenesis could be associated with altered immune cell plasma membrane lipids and lipoprotein metabolism Lupus Science & Medicine. 5. DOI: 10.1136/Lupus-2018-Abstract.132 |
0.36 |
|
| 2016 |
Munkacsi AB, Hammond N, Schneider RT, Senanayake DS, Higaki K, Lagutin K, Bloor SJ, Ory DS, Maue RA, Chen FW, Hernandez-Ono A, Dahlson N, Repa JJ, Ginsberg HN, Ioannou YA, et al. Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat. The Journal of Biological Chemistry. PMID 28031458 DOI: 10.1074/Jbc.M116.770578 |
0.621 |
|
| 2015 |
Croca S, Bassett P, Chambers S, Davari M, Alber KF, Leach O, Ioannou Y, Giles I, Isenberg D, Rahman A. IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study. Arthritis Research & Therapy. 17: 26. PMID 25890187 DOI: 10.1186/S13075-015-0539-Z |
0.308 |
|
| 2014 |
Ripoll VM, Lambrianides A, Pierangeli SS, Poulton K, Ioannou Y, Heywood WE, Mills K, Latchman DS, Isenberg DA, Rahman A, Giles IP. Changes in regulation of human monocyte proteins in response to IgG from patients with antiphospholipid syndrome. Blood. 124: 3808-16. PMID 25301710 DOI: 10.1182/Blood-2014-05-577569 |
0.33 |
|
| 2013 |
Tamari F, Chen FW, Li C, Chaudhari J, Ioannou YA. PKC activation in Niemann pick C1 cells restores subcellular cholesterol transport. Plos One. 8: e74169. PMID 23977398 DOI: 10.1371/Journal.Pone.0074169 |
0.631 |
|
| 2012 |
Liapis A, Chen FW, Davies JP, Wang R, Ioannou YA. MLN64 transport to the late endosome is regulated by binding to 14-3-3 via a non-canonical binding site Plos One. 7. PMID 22514632 DOI: 10.1371/Journal.Pone.0034424 |
0.741 |
|
| 2012 |
Ioannou Y. The Michael Mason prize: Pathogenic antiphospholipid antibodies, stressed out antigens and the deployment of decoys Rheumatology. 51: 32-36. PMID 22120465 DOI: 10.1093/Rheumatology/Ker353 |
0.301 |
|
| 2012 |
Heathfield S, Parker B, Zeef L, Bruce I, Alexander Y, Collins F, Stone M, Wang E, Williams AS, Wright HL, Thomas HB, Moots RJ, Edwards SW, Bullock C, Chapman V, ... ... Ioannou Y, et al. Basic science232. Certolizumab pegol prevents pro-inflammatory alterations in endothelial cell function Rheumatology. 51. DOI: 10.1093/Rheumatology/Kes108 |
0.315 |
|
| 2011 |
Ioannou Y, Zhang JY, Qi M, Gao L, Qi JC, Yu DM, Lau H, Sturgess AD, Vlachoyiannopoulos PG, Moutsopoulos HM, Rahman A, Pericleous C, Atsumi T, Koike T, Heritier S, et al. Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modification of the major autoantigen β2-glycoprotein I. Arthritis and Rheumatism. 63: 2774-82. PMID 21618459 DOI: 10.1002/Art.30383 |
0.328 |
|
| 2011 |
Munkacsi AB, Chen FW, Brinkman MA, Higaki K, Gutiérrez GD, Chaudhari J, Layer JV, Tong A, Bard M, Boone C, Ioannou YA, Sturley SL. An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease. The Journal of Biological Chemistry. 286: 23842-51. PMID 21489983 DOI: 10.1074/Jbc.M111.227645 |
0.619 |
|
| 2010 |
Chen FW, Li C, Ioannou YA. Cyclodextrin induces calcium-dependent lysosomal exocytosis. Plos One. 5: e15054. PMID 21124786 DOI: 10.1371/Journal.Pone.0015054 |
0.59 |
|
| 2010 |
Ioannou Y, Rahman A. Domain I of β2-glycoprotein I: its role as an epitope and the potential to be developed as a specific target for the treatment of the antiphospholipid syndrome Lupus. 19: 400-405. PMID 20353977 DOI: 10.1177/0961203309360544 |
0.315 |
|
| 2009 |
Temel RE, Brown JM, Ma Y, Tang W, Rudel LL, Ioannou YA, Davies JP, Yu L. Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent Journal of Lipid Research. 50: 915-923. PMID 19141868 DOI: 10.1194/Jlr.M800631-Jlr200 |
0.31 |
|
| 2009 |
Walter M, Chen FW, Tamari F, Wang R, Ioannou YA. Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 101: 141-52. PMID 18681838 DOI: 10.1042/Bc20070171 |
0.608 |
|
| 2008 |
Tang W, Ma Y, Jia L, Ioannou YA, Davies JP, Yu L. Niemann-pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 448-454. PMID 18187667 DOI: 10.1161/Atvbaha.107.160465 |
0.309 |
|
| 2007 |
Knöpfel M, Davies JP, Duong PT, Kvaernø L, Carreira EM, Phillips MC, Ioannou YA, Hauser H. Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane. Biochimica Et Biophysica Acta. 1771: 1140-7. PMID 17689140 DOI: 10.1016/J.Bbalip.2007.05.011 |
0.331 |
|
| 2007 |
Temel RE, Tang W, Ma Y, Rudel LL, Willingham MC, Ioannou YA, Davies JP, Nilsson LM, Yu L. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe Journal of Clinical Investigation. 117: 1968-1978. PMID 17571164 DOI: 10.1172/Jci30060 |
0.314 |
|
| 2007 |
Labonté ED, Howles PN, Granholm NA, Rojas JC, Davies JP, Ioannou YA, Hui DY. Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1771: 1132-1139. PMID 17442616 DOI: 10.1016/J.Bbalip.2007.03.002 |
0.324 |
|
| 2007 |
Ioannou YA. Niemann-Pick C proteins in sterol transport and absorption: flies in the ointment. Developmental Cell. 12: 481-3. PMID 17419988 DOI: 10.1016/J.Devcel.2007.03.017 |
0.317 |
|
| 2007 |
Suzuki M, Sugimoto Y, Ohsaki Y, Ueno M, Kato S, Kitamura Y, Hosokawa H, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H. Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activation in the NPC brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1879-91. PMID 17314284 DOI: 10.1523/Jneurosci.5282-06.2007 |
0.316 |
|
| 2006 |
Ohsaki Y, Sugimoto Y, Suzuki M, Hosokawa H, Yoshimori T, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H. Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4. Journal of Cell Science. 119: 2643-53. PMID 16757520 DOI: 10.1242/Jcs.02993 |
0.368 |
|
| 2006 |
Davies JP, Ioannou YA. The role of the Niemann-Pick C1-like 1 protein in the subcellular transport of multiple lipids and their homeostasis Current Opinion in Lipidology. 17: 221-226. PMID 16680025 DOI: 10.1097/01.Mol.0000226112.12684.5E |
0.331 |
|
| 2005 |
Ioannou YA. Guilty until proven innocent: the case of NPC1 and cholesterol. Trends in Biochemical Sciences. 30: 498-505. PMID 16054367 DOI: 10.1016/J.Tibs.2005.07.007 |
0.346 |
|
| 2005 |
Chen FW, Gordon RE, Ioannou YA. NPC1 late endosomes contain elevated levels of non-esterified ('free') fatty acids and an abnormally glycosylated form of the NPC2 protein. The Biochemical Journal. 390: 549-61. PMID 15896196 DOI: 10.1042/Bj20050236 |
0.646 |
|
| 2005 |
Davies JP, Scott C, Oishi K, Liapis A, Ioannou YA. Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia Journal of Biological Chemistry. 280: 12710-12720. PMID 15671032 DOI: 10.1074/Jbc.M409110200 |
0.754 |
|
| 2004 |
Scott C, Ioannou YA. The NPC1 protein: structure implies function. Biochimica Et Biophysica Acta. 1685: 8-13. PMID 15465421 DOI: 10.1016/J.Bbalip.2004.08.006 |
0.358 |
|
| 2004 |
Scott C, Higgins ME, Davies JP, Ioannou YA. Targeting of NPC1 to late endosomes involves multiple signals, including one residing within the putative sterol-sensing domain Journal of Biological Chemistry. 279: 48214-48233. PMID 15347664 DOI: 10.1074/Jbc.M406090200 |
0.669 |
|
| 2004 |
Ohsaki Y, Sugimoto Y, Suzuki M, Kaidoh T, Shimada Y, Ohno-Iwashita Y, Davies JP, Ioannou YA, Ohno K, Ninomiya H. Reduced sensitivity of Niemann-Pick C1-deficient cells to θ-toxin (perfringolysin O): Sequestration of toxin to raft-enriched membrane vesicles Histochemistry and Cell Biology. 121: 263-272. PMID 15069562 DOI: 10.1007/S00418-004-0643-7 |
0.328 |
|
| 2003 |
Ioannou YA, Enriquez A, Benjamin C. Gene therapy for lysosomal storage disorders. Expert Opinion On Biological Therapy. 3: 789-801. PMID 12880379 DOI: 10.1517/14712598.3.5.789 |
0.695 |
|
| 2003 |
Walter M, Davies JP, Ioannou YA. Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes Journal of Lipid Research. 44: 243-253. PMID 12576506 DOI: 10.1194/Jlr.M200230-Jlr200 |
0.359 |
|
| 2001 |
Higgins ME, Ioannou YA. Apoptosis-induced release of mature sterol regulatory element-binding proteins activates sterol-responsive genes. Journal of Lipid Research. 42: 1939-46. PMID 11734566 |
0.651 |
|
| 2001 |
Sugimoto Y, Ninomiya H, Ohsaki Y, Higaki K, Davies JP, Ioannou YA, Ohno K. Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann-Pick C1-deficient cells. Proceedings of the National Academy of Sciences of the United States of America. 98: 12391-6. PMID 11675488 DOI: 10.1073/Pnas.221181998 |
0.348 |
|
| 2001 |
Ioannou YA. Multidrug permeases and subcellular cholesterol transport. Nature Reviews. Molecular Cell Biology. 2: 657-68. PMID 11533723 DOI: 10.1038/35089558 |
0.355 |
|
| 2000 |
Davies JP, Chen FW, Ioannou YA. Transmembrane molecular pump activity of Niemann-Pick C1 protein. Science (New York, N.Y.). 290: 2295-8. PMID 11125140 DOI: 10.1126/Science.290.5500.2295 |
0.628 |
|
| 2000 |
Ioannou YA. The structure and function of the Niemann-Pick C1 protein. Molecular Genetics and Metabolism. 71: 175-81. PMID 11001808 DOI: 10.1006/Mgme.2000.3061 |
0.376 |
|
| 2000 |
Davies JP, Ioannou YA. Topological analysis of Niemann-Pick C1 protein reveals that the membrane orientation of the putative sterol-sensing domain is identical to those of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein cleavage-activating protein. The Journal of Biological Chemistry. 275: 24367-74. PMID 10821832 DOI: 10.1074/Jbc.M002184200 |
0.335 |
|
| 2000 |
Davies JP, Levy B, Ioannou YA. Evidence for a Niemann-pick C (NPC) gene family: identification and characterization of NPC1L1. Genomics. 65: 137-45. PMID 10783261 DOI: 10.1006/Geno.2000.6151 |
0.364 |
|
| 1999 |
Chen FW, Ioannou YA. Ribosomal proteins in cell proliferation and apoptosis. International Reviews of Immunology. 18: 429-48. PMID 10672495 DOI: 10.3109/08830189909088492 |
0.601 |
|
| 1999 |
Higgins ME, Davies JP, Chen FW, Ioannou YA. Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network. Molecular Genetics and Metabolism. 68: 1-13. PMID 10479477 DOI: 10.1006/Mgme.1999.2882 |
0.76 |
|
| 1999 |
Ziegler RJ, Yew NS, Li C, Cherry M, Berthelette P, Romanczuk H, Ioannou YA, Zeidner KM, Desnick RJ, Cheng SH. Correction of enzymatic and lysosomal storage defects in Fabry mice by adenovirus-mediated gene transfer. Human Gene Therapy. 10: 1667-82. PMID 10428212 DOI: 10.1089/10430349950017671 |
0.319 |
|
| 1998 |
Chen FW, Davies JP, Ioannou YA. Differential gene expression in apoptosis: identification of ribosomal protein 23K, a cell proliferation inhibitor. Molecular Genetics and Metabolism. 64: 271-82. PMID 9758718 DOI: 10.1006/Mgme.1998.2718 |
0.597 |
|
| 1998 |
Rattazzi MC, Tsuda T, Benjamin CJ, Gordon RE, Friedrich VL, Desnick RJ, Ioannou YA. Delivery of Compacted DNA Across the Blood-Brain Barrier ♦ 732 Pediatric Research. 43: 127-127. DOI: 10.1203/00006450-199804001-00753 |
0.723 |
|
| 1997 |
Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, Cummings C, Gu J, Rosenfeld MA, Pavan WJ, Krizman DB, Nagle J, Polymeropoulos MH, Sturley SL, Ioannou YA, Higgins ME, et al. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science (New York, N.Y.). 277: 228-31. PMID 9211849 DOI: 10.1126/Science.277.5323.228 |
0.683 |
|
| 1997 |
Davies JP, Cotter PD, Ioannou YA. Cloning and mapping of human Rab7 and Rab9 cDNA sequences and identification of a Rab9 pseudogene Genomics. 41: 131-134. PMID 9126495 DOI: 10.1006/Geno.1997.4644 |
0.315 |
|
| 1996 |
Ioannou YA, Chen FW. Quantitation of DNA fragmentation in apoptosis. Nucleic Acids Research. 24: 992-3. PMID 8600475 |
0.499 |
|
| 1995 |
Schuchman EH, Ioannou YA, Rattazzi MC, Desnick RJ. Neural gene therapy for inherited diseases with mental retardation: Principles and prospects Mental Retardation and Developmental Disabilities Research Reviews. 1: 39-48. DOI: 10.1002/Mrdd.1410010109 |
0.311 |
|
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