Yiannis A. Ioannou - Publications

Affiliations: 
Icahn School of Medicine at Mount Sinai, New York, NY, United States 
Area:
Genetics, Molecular Biology, Cell Biology

31 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Munkacsi AB, Hammond N, Schneider RT, Senanayake DS, Higaki K, Lagutin K, Bloor SJ, Ory DS, Maue RA, Chen FW, Hernandez-Ono A, Dahlson N, Repa JJ, Ginsberg HN, Ioannou YA, et al. Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat. The Journal of Biological Chemistry. PMID 28031458 DOI: 10.1074/jbc.M116.770578  0.92
2013 Tamari F, Chen FW, Li C, Chaudhari J, Ioannou YA. PKC activation in Niemann pick C1 cells restores subcellular cholesterol transport. Plos One. 8: e74169. PMID 23977398 DOI: 10.1371/journal.pone.0074169  0.92
2012 Liapis A, Chen FW, Davies JP, Wang R, Ioannou YA. MLN64 transport to the late endosome is regulated by binding to 14-3-3 via a non-canonical binding site Plos One. 7. PMID 22514632 DOI: 10.1371/journal.pone.0034424  0.44
2011 Munkacsi AB, Chen FW, Brinkman MA, Higaki K, Gutiérrez GD, Chaudhari J, Layer JV, Tong A, Bard M, Boone C, Ioannou YA, Sturley SL. An "exacerbate-reverse" strategy in yeast identifies histone deacetylase inhibition as a correction for cholesterol and sphingolipid transport defects in human Niemann-Pick type C disease. The Journal of Biological Chemistry. 286: 23842-51. PMID 21489983 DOI: 10.1074/jbc.M111.227645  0.44
2010 Chen FW, Li C, Ioannou YA. Cyclodextrin induces calcium-dependent lysosomal exocytosis. Plos One. 5: e15054. PMID 21124786 DOI: 10.1371/journal.pone.0015054  0.92
2009 Temel RE, Brown JM, Ma Y, Tang W, Rudel LL, Ioannou YA, Davies JP, Yu L. Diosgenin stimulation of fecal cholesterol excretion in mice is not NPC1L1 dependent Journal of Lipid Research. 50: 915-923. PMID 19141868 DOI: 10.1194/jlr.M800631-JLR200  0.44
2009 Tang W, Ma Y, Jia L, Ioannou YA, Davies JP, Yu L. Genetic inactivation of NPC1L1 protects against sitosterolemia in mice lacking ABCG5/ABCG8 Journal of Lipid Research. 50: 293-300. PMID 18796403 DOI: 10.1194/jlr.M800439-JLR200  0.44
2009 Walter M, Chen FW, Tamari F, Wang R, Ioannou YA. Endosomal lipid accumulation in NPC1 leads to inhibition of PKC, hypophosphorylation of vimentin and Rab9 entrapment. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 101: 141-52. PMID 18681838 DOI: 10.1042/BC20070171  0.92
2008 Labonté ED, Camarota LM, Rojas JC, Jandacek RJ, Gilham DE, Davies JP, Ioannou YA, Tso P, Hui DY, Howles PN. Reduced absorption of saturated fatty acids and resistance to diet-induced obesity and diabetes by ezetimibe-treated and Npc1l1-/- mice American Journal of Physiology - Gastrointestinal and Liver Physiology. 295: G776-G783. PMID 18718999 DOI: 10.1152/ajpgi.90275.2008  0.44
2008 Tang W, Ma Y, Jia L, Ioannou YA, Davies JP, Yu L. Niemann-pick C1-like 1 is required for an LXR agonist to raise plasma HDL cholesterol in mice Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 448-454. PMID 18187667 DOI: 10.1161/ATVBAHA.107.160465  0.44
2007 Knöpfel M, Davies JP, Duong PT, Kvaernø L, Carreira EM, Phillips MC, Ioannou YA, Hauser H. Multiple plasma membrane receptors but not NPC1L1 mediate high-affinity, ezetimibe-sensitive cholesterol uptake into the intestinal brush border membrane. Biochimica Et Biophysica Acta. 1771: 1140-7. PMID 17689140 DOI: 10.1016/j.bbalip.2007.05.011  0.44
2007 Temel RE, Tang W, Ma Y, Rudel LL, Willingham MC, Ioannou YA, Davies JP, Nilsson LM, Yu L. Hepatic Niemann-Pick C1-like 1 regulates biliary cholesterol concentration and is a target of ezetimibe Journal of Clinical Investigation. 117: 1968-1978. PMID 17571164 DOI: 10.1172/JCI30060  0.44
2007 Labonté ED, Howles PN, Granholm NA, Rojas JC, Davies JP, Ioannou YA, Hui DY. Class B type I scavenger receptor is responsible for the high affinity cholesterol binding activity of intestinal brush border membrane vesicles Biochimica Et Biophysica Acta - Molecular and Cell Biology of Lipids. 1771: 1132-1139. PMID 17442616 DOI: 10.1016/j.bbalip.2007.03.002  0.44
2007 Suzuki M, Sugimoto Y, Ohsaki Y, Ueno M, Kato S, Kitamura Y, Hosokawa H, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H. Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activation in the NPC brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1879-91. PMID 17314284 DOI: 10.1523/JNEUROSCI.5282-06.2007  0.44
2006 Ohsaki Y, Sugimoto Y, Suzuki M, Hosokawa H, Yoshimori T, Davies JP, Ioannou YA, Vanier MT, Ohno K, Ninomiya H. Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4. Journal of Cell Science. 119: 2643-53. PMID 16757520 DOI: 10.1242/jcs.02993  0.44
2006 Davies JP, Ioannou YA. The role of the Niemann-Pick C1-like 1 protein in the subcellular transport of multiple lipids and their homeostasis Current Opinion in Lipidology. 17: 221-226. PMID 16680025 DOI: 10.1097/01.mol.0000226112.12684.5e  0.44
2005 Chen FW, Gordon RE, Ioannou YA. NPC1 late endosomes contain elevated levels of non-esterified ('free') fatty acids and an abnormally glycosylated form of the NPC2 protein. The Biochemical Journal. 390: 549-61. PMID 15896196 DOI: 10.1042/BJ20050236  0.92
2005 Davies JP, Scott C, Oishi K, Liapis A, Ioannou YA. Inactivation of NPC1L1 causes multiple lipid transport defects and protects against diet-induced hypercholesterolemia Journal of Biological Chemistry. 280: 12710-12720. PMID 15671032 DOI: 10.1074/jbc.M409110200  0.44
2004 Scott C, Higgins ME, Davies JP, Ioannou YA. Targeting of NPC1 to late endosomes involves multiple signals, including one residing within the putative sterol-sensing domain Journal of Biological Chemistry. 279: 48214-48233. PMID 15347664 DOI: 10.1074/jbc.M406090200  0.44
2004 Ohsaki Y, Sugimoto Y, Suzuki M, Kaidoh T, Shimada Y, Ohno-Iwashita Y, Davies JP, Ioannou YA, Ohno K, Ninomiya H. Reduced sensitivity of Niemann-Pick C1-deficient cells to θ-toxin (perfringolysin O): Sequestration of toxin to raft-enriched membrane vesicles Histochemistry and Cell Biology. 121: 263-272. PMID 15069562 DOI: 10.1007/s00418-004-0643-7  0.44
2003 Walter M, Davies JP, Ioannou YA. Telomerase immortalization upregulates Rab9 expression and restores LDL cholesterol egress from Niemann-Pick C1 late endosomes Journal of Lipid Research. 44: 243-253. PMID 12576506 DOI: 10.1194/jlr.M200230-JLR200  0.44
2002 Oishi K, Hofmann S, Diaz GA, Brown T, Manwani D, Ng L, Young R, Vlassara H, Ioannou YA, Forrest D, Gelb BD. Targeted disruption of Slc19a2, the gene encoding the high-affinity thiamin transporter Thtr-1, causes diabetes mellitus, sensorineural deafness and megaloblastosis in mice. Human Molecular Genetics. 11: 2951-60. PMID 12393806  0.32
2002 Ziegler RJ, Li C, Cherry M, Zhu Y, Hempel D, van Rooijen N, Ioannou YA, Desnick RJ, Goldberg MA, Yew NS, Cheng SH. Correction of the nonlinear dose response improves the viability of adenoviral vectors for gene therapy of Fabry disease. Human Gene Therapy. 13: 935-45. PMID 12031126 DOI: 10.1089/10430340252939041  0.44
2002 Stern AS, Klotman ME, Ioannou YA, Burrow CR, Wilson PD, Klotman PE, Lipkowitz MS. Polarity of alpha-galactosidase A uptake by renal tubule cells. Kidney International. 61: S52-5. PMID 11841613 DOI: 10.1046/j.1523-1755.2002.0610s1052.x  0.44
2001 Higgins ME, Ioannou YA. Apoptosis-induced release of mature sterol regulatory element-binding proteins activates sterol-responsive genes. Journal of Lipid Research. 42: 1939-46. PMID 11734566  0.76
2000 Davies JP, Chen FW, Ioannou YA. Transmembrane molecular pump activity of Niemann-Pick C1 protein. Science (New York, N.Y.). 290: 2295-8. PMID 11125140 DOI: 10.1126/science.290.5500.2295  0.92
1999 Chen FW, Ioannou YA. Ribosomal proteins in cell proliferation and apoptosis. International Reviews of Immunology. 18: 429-48. PMID 10672495  0.92
1999 Higgins ME, Davies JP, Chen FW, Ioannou YA. Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network. Molecular Genetics and Metabolism. 68: 1-13. PMID 10479477 DOI: 10.1006/mgme.1999.2882  0.92
1998 Chen FW, Davies JP, Ioannou YA. Differential gene expression in apoptosis: identification of ribosomal protein 23K, a cell proliferation inhibitor. Molecular Genetics and Metabolism. 64: 271-82. PMID 9758718 DOI: 10.1006/mgme.1998.2718  0.92
1997 Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, Cummings C, Gu J, Rosenfeld MA, Pavan WJ, Krizman DB, Nagle J, Polymeropoulos MH, Sturley SL, Ioannou YA, Higgins ME, et al. Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis. Science (New York, N.Y.). 277: 228-31. PMID 9211849 DOI: 10.1126/science.277.5323.228  0.44
1996 Ioannou YA, Chen FW. Quantitation of DNA fragmentation in apoptosis. Nucleic Acids Research. 24: 992-3. PMID 8600475  0.92
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