Amato J. Giaccia - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
Oncology, Cell Biology, Animal Physiology Biology

215 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Mehibel M, Xu Y, Li CG, Moon EJ, Thakkar KN, Diep AN, Kim RK, Bloomstein JD, Xiao Y, Bacal J, Saldivar JC, Le QT, Cimprich KA, Rankin EB, Giaccia AJ. Eliminating hypoxic tumor cells improves response to PARP inhibitors in homologous recombination-deficient cancer models. The Journal of Clinical Investigation. 131. PMID 34060485 DOI: 10.1172/JCI146256  0.44
2021 Grachan JJ, Kery M, Giaccia AJ, Denko NC, Papandreou I. Lipid droplet storage promotes murine pancreatic tumor growth. Oncology Reports. 45: 1. PMID 33649859 DOI: 10.3892/or.2021.7972  0.68
2020 Nishioka S, Wu PH, Yakabe T, Giaccia AJ, Le QT, Aoyama H, Shimizu S, Shirato H, Onodera Y, Nam JM. Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma. Neuro-Oncology Advances. 2: vdaa091. PMID 33409495 DOI: 10.1093/noajnl/vdaa091  0.44
2020 Tailor D, Going CC, Resendez A, Kumar V, Nambiar DK, Li Y, Dheeraj A, LaGory EL, Ghoochani A, Birk AM, Stoyanova T, Ye J, Giaccia AJ, Le QT, Singh RP, et al. Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer. British Journal of Cancer. PMID 33139797 DOI: 10.1038/s41416-020-01137-4  0.44
2020 Wu PH, Onodera Y, Giaccia AJ, Le QT, Shimizu S, Shirato H, Nam JM. Lysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation. Communications Biology. 3: 620. PMID 33110168 DOI: 10.1038/s42003-020-01339-9  0.44
2020 Cui L, Gouw AM, LaGory EL, Guo S, Attarwala N, Tang Y, Qi J, Chen YS, Gao Z, Casey KM, Bazhin AA, Chen M, Hu L, Xie J, Fang M, ... ... Giaccia AJ, et al. Mitochondrial copper depletion suppresses triple-negative breast cancer in mice. Nature Biotechnology. PMID 33077961 DOI: 10.1038/s41587-020-0707-9  0.44
2020 Klockow JL, Hettie KS, LaGory EL, Moon EJ, Giaccia AJ, Graves EE, Chin FT. An Activatable NIR Fluorescent Rosol for Selectively Imaging Nitroreductase Activity. Sensors and Actuators. B, Chemical. 306. PMID 32265579 DOI: 10.1016/J.Snb.2019.127446  0.4
2020 Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, Chi JA, Jeffrey SS, Giaccia AJ. Retraction Note: Lysyl oxidase is essential for hypoxia-induced metastasis. Nature. 579: 456. PMID 32188947 DOI: 10.1038/S41586-020-2112-4  0.44
2020 Aguilera TA, Elghonaimy E, Shehade H, Rafat M, Castellini L, Jiang D, Kariolis M, Koong A, Le QT, Ellies LG, Rankin EB, Graves EE, Giaccia AJ. Induced tumor heterogeneity reveals factors informing radiation and immunotherapy combinations. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32098769 DOI: 10.1158/1078-0432.Ccr-19-4220  0.44
2020 Li Y, Gruber JJ, Litzenburger UM, Zhou Y, Miao YR, LaGory EL, Li AM, Hu Z, Yip M, Hart LS, Maris JM, Chang HY, Giaccia AJ, Ye J. Acetate supplementation restores chromatin accessibility and promotes tumor cell differentiation under hypoxia. Cell Death & Disease. 11: 102. PMID 32029721 DOI: 10.1038/S41419-020-2303-9  0.4
2019 Nambiar DK, Aguilera T, Cao H, Kwok S, Kong C, Bloomstein J, Wang Z, Rangan VS, Jiang D, von Eyben R, Liang R, Agarwal S, Colevas AD, Korman A, Allen CT, ... ... Giaccia A, et al. Galectin-1-driven T cell exclusion in the tumor endothelium promotes immunotherapy resistance. The Journal of Clinical Investigation. PMID 31710313 DOI: 10.1172/Jci129025  0.6
2019 Gholamin S, Youssef OA, Rafat M, Esparza R, Kahn S, Shahin M, Giaccia AJ, Graves EE, Weissman I, Mitra S, Cheshier SH. Irradiation or temozolomide chemotherapy enhances anti-CD47 treatment of glioblastoma. Innate Immunity. 1753425919876690. PMID 31547758 DOI: 10.1177/1753425919876690  0.4
2019 Wu PH, Onodera Y, Recuenco FC, Giaccia AJ, Le QT, Shimizu S, Shirato H, Nam JM. Lambda-Carrageenan Enhances the Effects of Radiation Therapy in Cancer Treatment by Suppressing Cancer Cell Invasion and Metastasis through Racgap1 Inhibition. Cancers. 11. PMID 31426369 DOI: 10.3390/Cancers11081192  0.44
2019 VandeKopple MJ, Wu J, Auer EN, Giaccia AJ, Denko NC, Papandreou I. HILPDA regulates lipid metabolism, lipid droplet abundance and response to microenvironmental stress in solid tumors. Molecular Cancer Research : McR. PMID 31308147 DOI: 10.1158/1541-7786.Mcr-18-1343  0.68
2019 Hacker BC, Alves SM, Jiang D, Koong AC, Giaccia AJ, Graves EE, Rafat M. Abstract 3931: The irradiated tissue microenvironment and its role in breast cancer recurrence: Enhanced macrophage infiltration promotes tumor cell recruitment Cancer Research. 79: 3931-3931. DOI: 10.1158/1538-7445.Am2019-3931  0.6
2019 Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le Q, Koong AC, Giaccia AJ, Chen C, Yu B, Papandreou I, Denko NC. Abstract 2927: Papaverine and its novel derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism Cancer Research. 79: 2927-2927. DOI: 10.1158/1538-7445.Am2019-2927  0.68
2018 Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen CS, Papandreou I, Denko NC. Erratum: Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism (Proceedings of the National Academy of Sciences of the United States of America (2018) 115 (10756–10761) DOI: 10.1073/pnas.1808945115) Proceedings of the National Academy of Sciences of the United States of America. 115. PMID 30455291 DOI: 10.1073/Pnas.1818732115  0.68
2018 Chen X, Litzenburger UM, Wei Y, Schep AN, LaGory EL, Choudhry H, Giaccia AJ, Greenleaf WJ, Chang HY. Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. Nature Communications. 9: 4590. PMID 30389926 DOI: 10.1038/S41467-018-07115-Y  0.4
2018 Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen SC, Papandreou I, Denko NC. Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proceedings of the National Academy of Sciences of the United States of America. PMID 30201710 DOI: 10.1073/Pnas.1808945115  0.68
2018 Rafat M, Aguilera TA, Vilalta M, Bronsart LL, Soto LA, von Eyben R, Golla MA, Ahrari Y, Melemenidis S, Afghahi A, Jenkins MJ, Kurian AW, Horst K, Giaccia AJ, Graves EE. Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence Following Radiation Therapy in Immunosuppressed Patients. Cancer Research. PMID 29880480 DOI: 10.1158/0008-5472.Can-17-3623  0.4
2018 Olcina MM, Kim RK, Melemenidis S, Graves EE, Giaccia AJ. The tumour microenvironment links complement system dysregulation and hypoxic signalling. The British Journal of Radiology. 20180069. PMID 29544344 DOI: 10.1259/Bjr.20180069  0.4
2018 Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. A Human Genome-wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1α-XBP1 Activation. Molecular Cancer Research : McR. PMID 29440447 DOI: 10.1158/1541-7786.Mcr-17-0307  0.68
2018 Shirato H, Le QT, Kobashi K, Prayongrat A, Takao S, Shimizu S, Giaccia A, Xing L, Umegaki K. Selection of external beam radiotherapy approaches for precise and accurate cancer treatment. Journal of Radiation Research. PMID 29373709 DOI: 10.1093/Jrr/Rrx092  0.44
2018 Ko SH, Nauta AC, Morrison SD, Hu MS, Zimmermann AS, Chung MT, Glotzbach JP, Wong VW, Walmsley GG, Peter Lorenz H, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT. PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing. Plastic and Reconstructive Surgery. 141: 55e-67e. PMID 29280872 DOI: 10.1097/Prs.0000000000003959  0.96
2017 Chiou SH, Risca VI, Wang GX, Yang D, Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, Castellini L, Graves EE, Kim GE, Mourrain P, Koong AC, ... Giaccia AJ, et al. Blimp1 induces transient metastatic heterogeneity in pancreatic cancer. Cancer Discovery. PMID 28790031 DOI: 10.1158/2159-8290.Cd-17-0250  0.6
2017 Castellini L, Moon EJ, Razorenova OV, Krieg AJ, von Eyben R, Giaccia AJ. KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Research. PMID 28073943 DOI: 10.1093/Nar/Gkw1281  0.4
2016 Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ. Reprogramming the immunological microenvironment through radiation and targeting Axl. Nature Communications. 7: 13898. PMID 28008921 DOI: 10.1038/Ncomms13898  0.6
2016 Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. The Journal of Clinical Investigation. PMID 27893463 DOI: 10.1172/Jci85610  0.6
2016 Vilalta M, Hughes NP, Von Eyben R, Giaccia AJ, Graves EE. Patterns of Vasculature in Mouse Models of Lung Cancer Are Dependent on Location. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. PMID 27709411 DOI: 10.1007/S11307-016-1010-5  0.4
2016 Jiang D, Lynch C, Medeiros BC, Liedtke M, Bam R, Tam AB, Yang Z, Alagappan M, Abidi P, Le QT, Giaccia AJ, Denko NC, Niwa M, Koong AC. Identification of Doxorubicin as an Inhibitor of the IRE1α-XBP1 Axis of the Unfolded Protein Response. Scientific Reports. 6: 33353. PMID 27634301 DOI: 10.1038/Srep33353  0.68
2016 Sun RC, Koong A, Giaccia A, Denko NC. Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells. Advances in Experimental Medicine and Biology. 899: 113-20. PMID 27325264 DOI: 10.1007/978-3-319-26666-4_7  0.68
2016 Olcina MM, Giaccia AJ, Hammond EM. Isolation of Proteins on Nascent DNA in Hypoxia and Reoxygenation Conditions. Advances in Experimental Medicine and Biology. 899: 27-40. PMID 27325260 DOI: 10.1007/978-3-319-26666-4_3  0.6
2016 Jiang D, Tam A, Alagappan M, Hay MP, Gupta A, Kozak M, Solow-Cordero DE, Lum PY, Denko N, Giaccia AJ, Le QT, Niwa M, Koong AC. Acridine Derivatives as Inhibitors of the IRE1α-XBP1 Pathway Cytotoxic to Human Multiple Myeloma. Molecular Cancer Therapeutics. PMID 27307600 DOI: 10.1158/1535-7163.Mct-15-1023  0.68
2016 Leszczynska KB, Göttgens EL, Biasoli D, Olcina MM, Ient J, Anbalagan S, Bernhardt S, Giaccia AJ, Hammond EM. Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1. Scientific Reports. 6: 21698. PMID 26875667 DOI: 10.1038/Srep21698  0.6
2016 Rafat M, Vilalta M, Aguilera TA, Giaccia AJ, Graves EE. Abstract 5124: Tumor and immune cell infiltration are enhanced by irradiation of normal tissues in immunocompromised mice Cancer Research. 76: 5124-5124. DOI: 10.1158/1538-7445.Am2016-5124  0.4
2016 Aguilera TA, Rafat MR, Castellini L, Kariolis MS, vonEbyen R, Graves EE, Giaccia AJ. Abstract 4988: Reprogramming the immunologic microenvironment through radiation and Axl targeting Cancer Research. 76: 4988-4988. DOI: 10.1158/1538-7445.Am2016-4988  0.4
2016 Moon EJ, Mello SS, Chi J, Krieg AJ, Giaccia A. Abstract 1628: MAFF, a new hypoxia target gene involving tumor invasion and metastasis Cancer Research. 76: 1628-1628. DOI: 10.1158/1538-7445.Am2016-1628  0.4
2016 Rankin EB, Nam JM, Giaccia AJ. Hypoxia: Signaling the Metastatic Cascade Trends in Cancer. 2: 295-304. DOI: 10.1016/j.trecan.2016.05.006  0.96
2015 Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Sandusky G, Abadie J, Lyons KM, Giaccia AJ, Schipani E. Fibrosis and Hypoxia-Inducible Factor-1α-Dependent Tumors of the Soft Tissue on Loss of Von Hippel-Lindau in Mesenchymal Progenitors. The American Journal of Pathology. 185: 3090-101. PMID 26348575 DOI: 10.1016/J.Ajpath.2015.07.008  0.96
2015 LaGory EL, Wu C, Taniguchi CM, Ding CC, Chi JT, von Eyben R, Scott DA, Richardson AD, Giaccia AJ. Suppression of PGC-1α Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma. Cell Reports. PMID 26119730 DOI: 10.1016/J.Celrep.2015.06.006  0.96
2015 Pollom EL, Deng L, Pai RK, Brown JM, Giaccia A, Loo BW, Shultz DB, Le QT, Koong AC, Chang DT. Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy. International Journal of Radiation Oncology, Biology, Physics. 92: 568-576. PMID 26068491 DOI: 10.1016/J.Ijrobp.2015.02.016  0.96
2015 Le QT, Shirato H, Giaccia AJ, Koong AC. Emerging Treatment Paradigms in Radiation Oncology. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 21: 3393-401. PMID 25991820 DOI: 10.1158/1078-0432.Ccr-14-1191  0.6
2015 Wu C, Rankin EB, Castellini L, Fernandez-Alcudia J, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ. Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin. Genes & Development. 29: 817-31. PMID 25846796 DOI: 10.1101/Gad.255000.114  0.96
2015 Aguilera TA, Giaccia AJ. The end of the hypoxic EPOch. International Journal of Radiation Oncology, Biology, Physics. 91: 895-7. PMID 25832683 DOI: 10.1016/J.Ijrobp.2015.01.041  0.96
2015 Finger EC, Castellini L, Rankin EB, Vilalta M, Krieg AJ, Jiang D, Banh A, Zundel W, Powell MB, Giaccia AJ. Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells. Proceedings of the National Academy of Sciences of the United States of America. 112: 4441-6. PMID 25792458 DOI: 10.1073/Pnas.1418164112  0.44
2015 Jiang D, LaGory EL, Kenzelmann Brož D, Bieging KT, Brady CA, Link N, Abrams JM, Giaccia AJ, Attardi LD. Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function. Cell Reports. 10: 1096-109. PMID 25704813 DOI: 10.1016/J.Celrep.2015.01.043  0.96
2015 Le QT, Shirato H, Giaccia AJ, Koong AC. Emerging treatment paradigms in radiation oncology Clinical Cancer Research. 21: 3393-3401. DOI: 10.1158/1078-0432.CCR-14-1191  0.6
2015 LaGory EL, Wu C, Taniguchi CM, Ding CKC, Chi JT, Eyben Rv, Scott DA, Richardson AD, Giaccia AJ. Erratum to Suppression of PGC-1a Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma [Cell Reports, 12, 2015, 116-127] Cell Reports. 12: 717. DOI: 10.1016/J.Celrep.2015.07.027  0.4
2014 Merceron C, Mangiavini L, Robling A, Wilson TL, Giaccia AJ, Shapiro IM, Schipani E, Risbud MV. Loss of HIF-1α in the notochord results in cell death and complete disappearance of the nucleus pulposus. Plos One. 9: e110768. PMID 25338007 DOI: 10.1371/Journal.Pone.0110768  0.96
2014 Kuo P, Bratman SV, Shultz DB, von Eyben R, Chan C, Wang Z, Say C, Gupta A, Loo BW, Giaccia AJ, Koong AC, Diehn M, Le QT. Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 20: 5558-69. PMID 25189484 DOI: 10.1158/1078-0432.Ccr-14-1138  0.96
2014 Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ. Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. Proceedings of the National Academy of Sciences of the United States of America. 111: 13373-8. PMID 25187556 DOI: 10.1073/Pnas.1404848111  0.96
2014 Xiao N, Lin Y, Cao H, Sirjani D, Giaccia AJ, Koong AC, Kong CS, Diehn M, Le QT. Neurotrophic factor GDNF promotes survival of salivary stem cells. The Journal of Clinical Investigation. 124: 3364-77. PMID 25036711 DOI: 10.1172/Jci74096  0.96
2014 Vilalta M, Rafat M, Giaccia AJ, Graves EE. Recruitment of circulating breast cancer cells is stimulated by radiotherapy. Cell Reports. 8: 402-9. PMID 25017065 DOI: 10.1016/J.Celrep.2014.06.011  0.96
2014 Koumenis C, Hammond E, Giaccia A. Tumor microenvironment and cellular stress: signaling, metabolism, imaging, and therapeutic targets. Preface. Advances in Experimental Medicine and Biology. 772: v-viii. PMID 24765667 DOI: 10.1007/978-1-4614-5915-6  0.56
2014 Zimmermann AS, Morrison SD, Hu MS, Li S, Nauta A, Sorkin M, Meyer NP, Walmsley GG, Maan ZN, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT. Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury. Plos One. 9: e93373. PMID 24695462 DOI: 10.1371/Journal.Pone.0093373  0.96
2014 Bonnet M, Flanagan JU, Chan DA, Giaccia AJ, Hay MP. Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents. Bioorganic & Medicinal Chemistry. 22: 711-20. PMID 24387866 DOI: 10.1016/J.Bmc.2013.12.028  0.96
2014 Razorenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Molecular and Cellular Biology. 34: 739-51. PMID 24344197 DOI: 10.1128/Mcb.00644-12  0.96
2014 Finger EC, Cheng CF, Williams TR, Rankin EB, Bedogni B, Tachiki L, Spong S, Giaccia AJ, Powell MB. CTGF is a therapeutic target for metastatic melanoma. Oncogene. 33: 1093-100. PMID 23435419 DOI: 10.1038/Onc.2013.47  0.96
2014 Kuo P, Bratman S, Shultz D, Eyben Rv, Chan C, Wang Z, Say C, Gupta A, Loo BW, Giaccia A, Koong A, Diehn M, Le Q. Abstract 848: Galectin-1 mediates radiation-related lymphopenia in non-small cell lung cancer and attenuates tumor radiation response Cancer Research. 74: 848-848. DOI: 10.1158/1538-7445.Am2014-848  0.36
2013 Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton LC, Lefai E, Simon MC, Maher JJ, ... ... Giaccia AJ, et al. A liver Hif-2α-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nature Medicine. 19: 1331-7. PMID 24037094 DOI: 10.1038/Nm.3295  0.96
2013 Taniguchi CM, Finger EC, Krieg AJ, Wu C, Diep AN, LaGory EL, Wei K, McGinnis LM, Yuan J, Kuo CJ, Giaccia AJ. Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Nature Medicine. 19: 1325-30. PMID 24037093 DOI: 10.1038/Nm.3294  0.96
2013 Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT. A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 19: 4455-64. PMID 23812668 DOI: 10.1158/1078-0432.Ccr-13-0127  0.96
2012 Catalina-Rodriguez O, Kolukula VK, Tomita Y, Preet A, Palmieri F, Wellstein A, Byers S, Giaccia AJ, Glasgow E, Albanese C, Avantaggiati ML. The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget. 3: 1220-35. PMID 23100451 DOI: 10.18632/Oncotarget.714  0.96
2012 Jonasch E, Futreal PA, Davis IJ, Bailey ST, Kim WY, Brugarolas J, Giaccia AJ, Kurban G, Pause A, Frydman J, Zurita AJ, Rini BI, Sharma P, Atkins MB, Walker CL, et al. State of the science: an update on renal cell carcinoma. Molecular Cancer Research : McR. 10: 859-80. PMID 22638109 DOI: 10.1158/1541-7786.Mcr-12-0117  0.96
2012 Krieg SA, Fan X, Hong Y, Sang QX, Giaccia A, Westphal LM, Lathi RB, Krieg AJ, Nayak NR. Global alteration in gene expression profiles of deciduas from women with idiopathic recurrent pregnancy loss. Molecular Human Reproduction. 18: 442-50. PMID 22505054 DOI: 10.1093/Molehr/Gas017  0.4
2012 Rankin EB, Wu C, Khatri R, Wilson TL, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, Giaccia AJ. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell. 149: 63-74. PMID 22464323 DOI: 10.1016/J.Cell.2012.01.051  0.96
2012 Le QT, Fisher R, Oliner KS, Young RJ, Cao H, Kong C, Graves E, Hicks RJ, McArthur GA, Peters L, O'Sullivan B, Giaccia A, Rischin D. Prognostic and predictive significance of plasma HGF and IL-8 in a phase III trial of chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 1798-807. PMID 22383739 DOI: 10.1158/1078-0432.Ccr-11-2094  0.96
2012 Maes C, Araldi E, Haigh K, Khatri R, Van Looveren R, Giaccia AJ, Haigh JJ, Carmeliet G, Schipani E. VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 27: 596-609. PMID 22162090 DOI: 10.1002/Jbmr.1487  0.96
2012 Lim AM, Rischin D, Fisher R, Cao H, Kwok K, Truong D, McArthur GA, Young RJ, Giaccia A, Peters L, Le QT. Prognostic significance of plasma osteopontin in patients with locoregionally advanced head and neck squamous cell carcinoma treated on TROG 02.02 phase III trial. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 18: 301-7. PMID 22096023 DOI: 10.1158/1078-0432.Ccr-11-2295  0.44
2011 Huang M, Nguyen P, Jia F, Hu S, Gong Y, de Almeida PE, Wang L, Nag D, Kay MA, Giaccia AJ, Robbins RC, Wu JC. Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction. Circulation. 124: S46-54. PMID 21911818 DOI: 10.1161/Circulationaha.110.014019  0.96
2011 Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan JU, Bouley DM, Graves EE, Denny WA, ... ... Giaccia AJ, et al. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Science Translational Medicine. 3: 94ra70. PMID 21813754 DOI: 10.1126/Scitranslmed.3002394  0.96
2011 Bonnet M, Flanagan JU, Chan DA, Lai EW, Nguyen P, Giaccia AJ, Hay MP. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells. Bioorganic & Medicinal Chemistry. 19: 3347-56. PMID 21561782 DOI: 10.1016/J.Bmc.2011.04.042  0.96
2011 Banh A, Zhang J, Cao H, Bouley DM, Kwok S, Kong C, Giaccia AJ, Koong AC, Le QT. Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis. Cancer Research. 71: 4423-31. PMID 21546572 DOI: 10.1158/0008-5472.Can-10-4157  0.6
2011 Chan DA, Giaccia AJ. Harnessing synthetic lethal interactions in anticancer drug discovery. Nature Reviews. Drug Discovery. 10: 351-64. PMID 21532565 DOI: 10.1038/Nrd3374  0.96
2011 Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proceedings of the National Academy of Sciences of the United States of America. 108: 1931-6. PMID 21233420 DOI: 10.1073/Pnas.1011777108  0.96
2011 Araldi E, Khatri R, Giaccia AJ, Simon MC, Schipani E. Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development. Nature Medicine. 17: 25-6; author reply 2. PMID 21217667 DOI: 10.1038/nm0111-25  0.96
2011 Banh A, Zhang J, Cao H, Bouley D, Kwok S, Kong C, Giaccia A, Koong A, Le Q. Abstract 1557: Tumor Galectin-1 mediates lung cancer growth and metastasis through immunoregulation of T-cell apoptosis Cancer Research. 71: 1557-1557. DOI: 10.1158/1538-7445.Am2011-1557  0.36
2011 Finger EC, Banh A, Rankin EB, Vilalta M, Krieg AJ, Broome-Powell M, Giaccia AJ. Abstract 1460: AKAP12 regulates melanoma tumor growth and metastasis Cancer Research. 71: 1460-1460. DOI: 10.1158/1538-7445.Am2011-1460  0.4
2011 Banh A, Zhang J, Cao H, Bouley D, Kwok S, Kong C, Giaccia A, Koong A, Le Q. 255 INVITED Targeting Galectin-1, a Hypoxia Induced Protein, in Non-Small Cell Lung Cancers European Journal of Cancer. 47. DOI: 10.1016/S0959-8049(11)70470-1  0.36
2010 Graves EE, Vilalta M, Cecic IK, Erler JT, Tran PT, Felsher D, Sayles L, Sweet-Cordero A, Le QT, Giaccia AJ. Hypoxia in models of lung cancer: implications for targeted therapeutics. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 4843-52. PMID 20858837 DOI: 10.1158/1078-0432.Ccr-10-1206  0.96
2010 Rankin EB, Fuh KC, Taylor TE, Krieg AJ, Musser M, Yuan J, Wei K, Kuo CJ, Longacre TA, Giaccia AJ. AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Research. 70: 7570-9. PMID 20858715 DOI: 10.1158/0008-5472.Can-10-1267  0.4
2010 Patten DA, Lafleur VN, Robitaille GA, Chan DA, Giaccia AJ, Richard DE. Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species. Molecular Biology of the Cell. 21: 3247-57. PMID 20660157 DOI: 10.1091/Mbc.E10-01-0025  0.96
2010 Wiley M, Sweeney KR, Chan DA, Brown KM, McMurtrey C, Howard EW, Giaccia AJ, Blader IJ. Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling. The Journal of Biological Chemistry. 285: 26852-60. PMID 20581113 DOI: 10.1074/Jbc.M110.147041  0.96
2010 Chan DA, Giaccia AJ. PHD2 in tumour angiogenesis. British Journal of Cancer. 103: 1-5. PMID 20461086 DOI: 10.1038/Sj.Bjc.6605682  0.96
2010 Huang X, Le QT, Giaccia AJ. MiR-210 - micromanager of the hypoxia pathway Trends in Molecular Medicine. 16: 230-237. PMID 20434954 DOI: 10.1016/J.Molmed.2010.03.004  0.96
2010 Courter D, Cao H, Kwok S, Kong C, Banh A, Kuo P, Bouley DM, Vice C, Brustugun OT, Denko NC, Koong AC, Giaccia A, Le QT. The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways. Plos One. 5: e9633. PMID 20224789 DOI: 10.1371/Journal.Pone.0009633  0.68
2010 Turcotte S, Giaccia AJ. Targeting cancer cells through autophagy for anticancer therapy. Current Opinion in Cell Biology. 22: 246-51. PMID 20056398 DOI: 10.1016/J.Ceb.2009.12.007  0.4
2010 Hay MP, Turcotte S, Flanagan JU, Bonnet M, Chan DA, Sutphin PD, Nguyen P, Giaccia AJ, Denny WA. 4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death. Journal of Medicinal Chemistry. 53: 787-97. PMID 19994864 DOI: 10.1021/Jm901457W  0.96
2010 Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Molecular and Cellular Biology. 30: 344-53. PMID 19858293 DOI: 10.1128/Mcb.00444-09  0.4
2010 Lai EW, Chan DA, Hay MP, Giaccia AJ. Abstract 67: Selective cytotoxic targeting of von Hippel-Lindau-deficient renal cell carcinoma cells Cancer Research. 70: 67-67. DOI: 10.1158/1538-7445.Am10-67  0.96
2010 Le QT, Courter D, Giaccia A. Hypoxia, angiogenesis, and oral cancer metastasis Oral Cancer Metastasis. 299-321. DOI: 10.1007/978-1-4419-0775-2_14  0.96
2009 Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 139: 891-906. PMID 19931152 DOI: 10.1016/J.Cell.2009.10.027  0.96
2009 Cairns RA, Bennewith KL, Graves EE, Giaccia AJ, Chang DT, Denko NC. Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 7170-4. PMID 19920111 DOI: 10.1158/1078-0432.Ccr-09-1676  0.68
2009 Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ. Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Molecular Cell. 35: 856-67. PMID 19782034 DOI: 10.1016/J.Molcel.2009.09.006  0.96
2009 Le QT, Harris J, Magliocco AM, Kong CS, Diaz R, Shin B, Cao H, Trotti A, Erler JT, Chung CH, Dicker A, Pajak TF, Giaccia AJ, Ang KK. Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 27: 4281-6. PMID 19667273 DOI: 10.1200/Jco.2008.20.6003  0.44
2009 Xu Y, Hammerick KE, James AW, Carre AL, Leucht P, Giaccia AJ, Longaker MT. Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells. Tissue Engineering. Part A. 15: 3697-707. PMID 19505250 DOI: 10.1089/Ten.Tea.2009.0213  0.96
2009 Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell. 15: 527-38. PMID 19477431 DOI: 10.1016/J.Ccr.2009.04.010  0.96
2009 Rankin EB, Giaccia AJ, Hammond EM. Bringing H2AX into the angiogenesis family. Cancer Cell. 15: 459-61. PMID 19477424 DOI: 10.1016/J.Ccr.2009.05.004  0.6
2009 Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE. Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood. 113: 5568-74. PMID 19336759 DOI: 10.1182/Blood-2008-10-185686  0.96
2009 Bennewith KL, Huang X, Ham CM, Graves EE, Erler JT, Kambham N, Feazell J, Yang GP, Koong A, Giaccia AJ. The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth. Cancer Research. 69: 775-84. PMID 19179545 DOI: 10.1158/0008-5472.Can-08-0987  0.4
2009 Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell. 15: 35-44. PMID 19111879 DOI: 10.1016/J.Ccr.2008.11.012  0.96
2009 Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM. ATM activation and signaling under hypoxic conditions. Molecular and Cellular Biology. 29: 526-37. PMID 18981219 DOI: 10.1128/Mcb.01301-08  0.6
2008 Choi CY, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS, Giaccia AJ. Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice. Molecular Imaging. 7: 139-46. PMID 19123984  0.96
2008 Torti FM, Altieri D, Broach J, Fan H, Lotze M, Manfredi J, Matrisian L, Yu D, Giaccia A. Ph.D. training in cancer biology Cancer Research. 68: 9122-9124. PMID 19010881 DOI: 10.1158/0008-5472.Can-08-2626  0.96
2008 Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC. Short hairpin RNA interference therapy for ischemic heart disease. Circulation. 118: S226-33. PMID 18824759 DOI: 10.1161/Circulationaha.107.760785  0.96
2008 Chan DA, Giaccia AJ. Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Cell Cycle (Georgetown, Tex.). 7: 2987-90. PMID 18818511 DOI: 10.4161/Cc.7.19.6776  0.96
2008 Turcotte S, Sutphin PD, Giaccia AJ. Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death. Autophagy. 4: 944-6. PMID 18769110 DOI: 10.4161/Auto.6785  0.96
2008 Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell. 14: 90-102. PMID 18598947 DOI: 10.1016/J.Ccr.2008.06.004  0.96
2008 Basak S, Jacobs SB, Krieg AJ, Pathak N, Zeng Q, Kaldis P, Giaccia AJ, Attardi LD. The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Molecular Cell. 30: 303-14. PMID 18471976 DOI: 10.1016/J.Molcel.2008.04.002  0.96
2008 Lauzier MC, Robitaille GA, Chan DA, Giaccia AJ, Richard DE. (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors. Molecular Pharmacology. 74: 282-8. PMID 18424552 DOI: 10.1124/Mol.108.045690  0.96
2008 Pagé EL, Chan DA, Giaccia AJ, Levine M, Richard DE. Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Molecular Biology of the Cell. 19: 86-94. PMID 17942596 DOI: 10.1091/Mbc.E07-06-0612  0.96
2008 Giaccia AJ, Choi CYH, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS. Molecular imaging of hypoxia-inducible factor 1α and von Hippel-Lindau interaction in mice Molecular Imaging. 7: 139-146. DOI: 10.2310/7290.2008.00017  0.96
2007 Chang EI, Loh SA, Ceradini DJ, Chang EI, Lin SE, Bastidas N, Aarabi S, Chan DA, Freedman ML, Giaccia AJ, Gurtner GC. Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation. 116: 2818-29. PMID 18040029 DOI: 10.1161/Circulationaha.107.715847  0.96
2007 Hammond EM, Kaufmann MR, Giaccia AJ. Oxygen sensing and the DNA-damage response. Current Opinion in Cell Biology. 19: 680-4. PMID 18023567 DOI: 10.1016/J.Ceb.2007.10.002  0.6
2007 Chan DA, Krieg AJ, Turcotte S, Giaccia AJ. HIF gene expression in cancer therapy. Methods in Enzymology. 435: 323-45. PMID 17998061 DOI: 10.1016/S0076-6879(07)35016-7  0.96
2007 Cecic I, Chan DA, Sutphin PD, Ray P, Gambhir SS, Giaccia AJ, Graves EE. Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia. Molecular Imaging. 6: 219-28. PMID 17711777 DOI: 10.2310/7290.2007.00017  0.96
2007 Le QT, Kong C, Lavori PW, O'byrne K, Erler JT, Huang X, Chen Y, Cao H, Tibshirani R, Denko N, Giaccia AJ, Koong AC. Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. International Journal of Radiation Oncology, Biology, Physics. 69: 167-75. PMID 17707270 DOI: 10.1016/J.Ijrobp.2007.01.071  0.6
2007 Sutphin PD, Chan DA, Li JM, Turcotte S, Krieg AJ, Giaccia AJ. Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells. Cancer Research. 67: 5896-905. PMID 17575159 DOI: 10.1158/0008-5472.Can-07-0604  0.96
2007 Sutphin PD, Giaccia AJ, Chan DA. Energy regulation: HIF MXIes it up with the C-MYC powerhouse. Developmental Cell. 12: 845-6. PMID 17543856 DOI: 10.1016/J.Devcel.2007.05.006  0.96
2007 Chan DA, Giaccia AJ. Hypoxia, gene expression, and metastasis. Cancer Metastasis Reviews. 26: 333-9. PMID 17458506 DOI: 10.1007/s10555-007-9063-1  0.96
2007 Graves EE, Giaccia AJ. Imaging tumoral hypoxia: oxygen concentrations and beyond. Oncology (Williston Park, N.Y.). 21: 368-76; discussion 3. PMID 17447439  0.4
2007 Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC. Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Molecular and Cellular Biology. 27: 912-25. PMID 17101781 DOI: 10.1128/Mcb.01223-06  0.96
2006 Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KS, Chapman JD, Eckelman WC, Fyles AW, Giaccia AJ, Hill RP, Koch CJ, Krishna MC, Krohn KA, Lewis JS, et al. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. International Journal of Radiation Biology. 82: 699-757. PMID 17118889 DOI: 10.1080/09553000601002324  0.96
2006 Petrik D, Lavori PW, Cao H, Zhu Y, Wong P, Christofferson E, Kaplan MJ, Pinto HA, Sutphin P, Koong AC, Giaccia AJ, Le QT. Plasma osteopontin is an independent prognostic marker for head and neck cancers. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 24: 5291-7. PMID 17114663 DOI: 10.1200/Jco.2006.06.8627  0.96
2006 Krieg AJ, Hammond EM, Giaccia AJ. Functional analysis of p53 binding under differential stresses. Molecular and Cellular Biology. 26: 7030-45. PMID 16980608 DOI: 10.1128/Mcb.00322-06  0.6
2006 Hammond EM, Giaccia AJ. Hypoxia-inducible factor-1 and p53: friends, acquaintances, or strangers? Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 5007-9. PMID 16951213 DOI: 10.1158/1078-0432.Ccr-06-0613  0.6
2006 Freiberg RA, Krieg AJ, Giaccia AJ, Hammond EM. Checking in on hypoxia/reoxygenation. Cell Cycle (Georgetown, Tex.). 5: 1304-7. PMID 16760660 DOI: 10.4161/Cc.5.12.2811  0.96
2006 Dornhöfer N, Spong S, Bennewith K, Salim A, Klaus S, Kambham N, Wong C, Kaper F, Sutphin P, Nacamuli R, Nacalumi R, Höckel M, Le Q, Longaker M, Yang G, ... ... Giaccia A, et al. Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer Research. 66: 5816-27. PMID 16740721 DOI: 10.1158/0008-5472.Can-06-0081  0.96
2006 Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, Chi JT, Jeffrey SS, Giaccia AJ. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature. 440: 1222-6. PMID 16642001 DOI: 10.1038/Nature04695  0.44
2006 Hammond EM, Mandell DJ, Salim A, Krieg AJ, Johnson TM, Shirazi HA, Attardi LD, Giaccia AJ. Genome-wide analysis of p53 under hypoxic conditions Molecular and Cellular Biology. 26: 3492-3504. PMID 16611991 DOI: 10.1128/Mcb.26.9.3492-3504.2006  0.96
2006 Le QT, Chen E, Salim A, Cao H, Kong CS, Whyte R, Donington J, Cannon W, Wakelee H, Tibshirani R, Mitchell JD, Richardson D, O'Byrne KJ, Koong AC, Giaccia AJ. An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 12: 1507-14. PMID 16533775 DOI: 10.1158/1078-0432.Ccr-05-2049  0.6
2006 Freiberg RA, Hammond EM, Dorie MJ, Welford SM, Giaccia AJ. DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Molecular and Cellular Biology. 26: 1598-609. PMID 16478982 DOI: 10.1128/Mcb.26.5.1598-1609.2006  0.96
2006 Kaper F, Dornhoefer N, Giaccia AJ. Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Cancer Research. 66: 1561-9. PMID 16452213 DOI: 10.1158/0008-5472.Can-05-3375  0.96
2006 Le QT, Cao H, Koong A, Giaccia A. Comment on: Osteopontin as toxic marker [1] Radiotherapy and Oncology. 78: 230. PMID 16442647 DOI: 10.1016/J.Radonc.2005.12.011  0.96
2006 Chi JT, Wang Z, Nuyten DS, Rodriguez EH, Schaner ME, Salim A, Wang Y, Kristensen GB, Helland A, Børresen-Dale AL, Giaccia A, Longaker MT, Hastie T, Yang GP, van de Vijver MJ, et al. Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. Plos Medicine. 3: e47. PMID 16417408 DOI: 10.1371/Journal.Pmed.0030047  0.96
2006 Hammond EM, Freiberg RA, Giaccia AJ. The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation. Cancer Letters. 238: 161-7. PMID 16085356 DOI: 10.1016/J.Canlet.2005.06.029  0.96
2006 Dornhöfer N, Spong S, Bennewith K, Salim A, Klaus S, Kambham N, Wong C, Kaper F, Sutphin P, Nacamuli R, Höckel M, Le Q, Longaker M, Yang G, Koong A, ... Giaccia A, et al. Erratum: Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis (Cancer Research (June 1, 2006) 66 (5816-5827)) Cancer Research. 66. DOI: 10.1158/0008-5472.Can-66-15-Cor  0.96
2005 Koong A, Kong C, Zhao S, Richardson D, O'Byrne K, Pinto H, Denko NC, Giaccia AJ, Le QT. Expression and prognostic significance of tissue hypoxia markers in head and neck squamous cell carcinomas (HNSCC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 5559. PMID 27945317 DOI: 10.1200/Jco.2005.23.16_Suppl.5559  0.68
2005 Le QT, Koong AC, Pinto HA, Giaccia AJ, Kong C. Expression of p16 as a prognostic marker in head and neck squamous cell carcinomas (HNSCC). Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 5520. PMID 27945247 DOI: 10.1200/Jco.2005.23.16_Suppl.5520  0.6
2005 Petrik DW, Cao H, Zhu Y, Wong P, Sutphin P, Giaccia AJ, Koong AA, Le QT. An expanded study of the relationship between osteopontin, tumor pO2 and prognosis in head and neck squamous cell carcinomas. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 5521. PMID 27945243 DOI: 10.1200/Jco.2005.23.16_Suppl.5521  0.44
2005 Spong SM, Dornhofer N, Wong C, Lomongsod E, Salim A, Le Q, Koong A, Klaus S, Giaccia A. Inhibition of pancreatic tumor growth and progression by a human monoclonal antibody specific for connective tissue growth factor. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 4150. PMID 27944587 DOI: 10.1200/Jco.2005.23.16_Suppl.4150  0.36
2005 Le QT, Shi G, Cao H, Nelson DW, Wang Y, Chen EY, Zhao S, Kong C, Richardson D, O'Byrne KJ, Giaccia AJ, Koong AC. Galectin-1: a link between tumor hypoxia and tumor immune privilege. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 23: 8932-41. PMID 16219933 DOI: 10.1200/Jco.2005.02.0206  0.6
2005 Chan DA, Sutphin PD, Yen SE, Giaccia AJ. Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha. Molecular and Cellular Biology. 25: 6415-26. PMID 16024780 DOI: 10.1128/Mcb.25.15.6415-6426.2005  0.96
2005 Nelson DW, Cao H, Zhu Y, Sunar-Reeder B, Choi CY, Faix JD, Brown JM, Koong AC, Giaccia AJ, Le QT. A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia. Cancer Research. 65: 6151-8. PMID 16024616 DOI: 10.1158/0008-5472.Can-04-2602  0.6
2005 Zhu Y, Denhardt DT, Cao H, Sutphin PD, Koong AC, Giaccia AJ, Le QT. Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer. Oncogene. 24: 6555-63. PMID 16007184 DOI: 10.1038/Sj.Onc.1208800  0.96
2005 Fang TD, Salim A, Xia W, Nacamuli RP, Guccione S, Song HM, Carano RA, Filvaroff EH, Bednarski MD, Giaccia AJ, Longaker MT. Angiogenesis is required for successful bone induction during distraction osteogenesis. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 20: 1114-24. PMID 15940364 DOI: 10.1359/Jbmr.050301  0.96
2005 Hammond EM, Giaccia AJ. The role of p53 in hypoxia-induced apoptosis. Biochemical and Biophysical Research Communications. 331: 718-25. PMID 15865928 DOI: 10.1016/J.Bbrc.2005.03.154  0.6
2005 Papandreou I, Krishna C, Kaper F, Cai D, Giaccia AJ, Denko NC. Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Research. 65: 3171-8. PMID 15833847 DOI: 10.1158/0008-5472.Can-04-3395  0.96
2005 Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Molecular Cell. 17: 503-12. PMID 15721254 DOI: 10.1016/J.Molcel.2005.01.011  0.96
2005 Johnson TM, Hammond EM, Giaccia A, Attardi LD. The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality Nature Genetics. 37: 145-152. PMID 15654339 DOI: 10.1038/Ng1498  0.96
2004 Chen Y, Shi G, Xia W, Kong C, Zhao S, Gaw AF, Chen EY, Yang GP, Giaccia AJ, Le QT, Koong AC. Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. Cancer Research. 64: 7302-10. PMID 15492250 DOI: 10.1158/0008-5472.Can-04-0899  0.6
2004 Hammond EM, Dorie MJ, Giaccia AJ. Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Research. 64: 6556-62. PMID 15374968 DOI: 10.1158/0008-5472.Can-04-1520  0.6
2004 Gerald D, Berra E, Frapart YM, Chan DA, Giaccia AJ, Mansuy D, Pouysségur J, Yaniv M, Mechta-Grigoriou F. JunD reduces tumor angiogenesis by protecting cells from oxidative stress Cell. 118: 781-794. PMID 15369676 DOI: 10.1016/J.Cell.2004.08.025  0.96
2004 Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Research. 64: 5943-7. PMID 15342372 DOI: 10.1158/0008-5472.Can-04-1606  0.68
2004 Hammond EM, Giaccia AJ. The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation. Dna Repair. 3: 1117-22. PMID 15279800 DOI: 10.1016/J.Dnarep.2004.03.035  0.6
2004 Soltys SG, Le QT, Shi G, Tibshirani R, Giaccia AJ, Koong AC. The use of plasma surface-enhanced laser desorption/ionization time-of-flight mass spectrometry proteomic patterns for detection of head and neck squamous cell cancers. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 10: 4806-12. PMID 15269156 DOI: 10.1158/1078-0432.Ccr-03-0469  0.6
2004 Salim A, Nacamuli RP, Morgan EF, Giaccia AJ, Longaker MT. Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. The Journal of Biological Chemistry. 279: 40007-16. PMID 15263007 DOI: 10.1074/Jbc.M403715200  0.96
2004 Leo C, Giaccia AJ, Denko NC. The hypoxic tumor microenvironment and gene expression. Seminars in Radiation Oncology. 14: 207-14. PMID 15254863 DOI: 10.1016/J.Semradonc.2004.04.007  0.68
2004 Le QT, Denko NC, Giaccia AJ. Hypoxic gene expression and metastasis Cancer and Metastasis Reviews. 23: 293-310. PMID 15197330 DOI: 10.1023/B:Canc.0000031768.89246.D7  0.96
2004 Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development (Cambridge, England). 131: 2497-508. PMID 15128677 DOI: 10.1242/Dev.01138  0.96
2004 Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W, Koch CJ, Maxwell P, et al. Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Research. 64: 3350-6. PMID 15126380 DOI: 10.1158/0008-5472.Can-03-2611  0.96
2004 Bemis L, Chan DA, Finkielstein CV, Qi L, Sutphin PD, Chen X, Stenmark K, Giaccia AJ, Zundel W. Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes & Development. 18: 739-44. PMID 15082527 DOI: 10.1101/Gad.1180104  0.96
2004 Swiersz LM, Giaccia AJ, Yun Z. Oxygen-dependent regulation of adipogenesis. Methods in Enzymology. 381: 387-95. PMID 15063688 DOI: 10.1016/S0076-6879(04)81026-7  0.96
2004 Bedogni B, O'Neill MS, Welford SM, Bouley DM, Giaccia AJ, Denko NC, Powell MB. Topical Treatment with Inhibitors of the Phosphatidylinositol 3′-Kinase/Akt and Raf/Mitogen-Activated Protein Kinase Kinase/Extracellular Signal-Regulated Kinase Pathways Reduces Melanoma Development in Severe Combined Immunodeficient Mice Cancer Research. 64: 2552-2560. PMID 15059911 DOI: 10.1158/0008-5472.Can-03-3327  0.96
2004 Sutphin PD, Chan DA, Giaccia AJ. Dead cells don't form tumors: HIF-dependent cytotoxins. Cell Cycle (Georgetown, Tex.). 3: 160-3. PMID 14712081  0.96
2004 Sutphin PD, Chan DA, Giaccia AJ. Dead Cells Don’t Form Tumors: HIF-Dependent Cytotoxins Cell Cycle. 3: 160-163. DOI: 10.4161/Cc.3.2.617  0.96
2003 Hammond EM, Green SL, Giaccia AJ. Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutation Research. 532: 205-13. PMID 14643437 DOI: 10.1016/J.Mrfmmm.2003.08.017  0.96
2003 Le QT, Giaccia AJ. Therapeutic exploitation of the physiological and molecular genetic alterations in head and neck cancer Clinical Cancer Research. 9: 4287-4295. PMID 14555497  0.96
2003 Denko NC, Fontana LA, Hudson KM, Sutphin PD, Raychaudhuri S, Altman R, Giaccia AJ. Investigating hypoxic tumor physiology through gene expression patterns. Oncogene. 22: 5907-14. PMID 12947397 DOI: 10.1038/Sj.Onc.1206703  0.96
2003 Le QT, Giaccia AJ. HIF-α, a gender independent transcription factor Clinical Cancer Research. 9: 2391-2393. PMID 12855609  0.96
2003 Le QT, Sutphin PD, Raychaudhuri S, Yu SC, Terris DJ, Lin HS, Lum B, Pinto HA, Koong AC, Giaccia AJ. Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 9: 59-67. PMID 12538452  0.96
2003 Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. The Journal of Biological Chemistry. 278: 12207-13. PMID 12519769 DOI: 10.1074/Jbc.M212360200  0.6
2002 Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Molecular and Cellular Biology. 22: 7004-14. PMID 12242281 DOI: 10.1128/Mcb.22.20.7004-7014.2002  0.96
2002 Maecker HL, Yun Z, Maecker HT, Giaccia AJ. Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. Cancer Cell. 2: 139-48. PMID 12204534 DOI: 10.1016/S1535-6108(02)00095-8  0.56
2002 Chan DA, Sutphin PD, Denko NC, Giaccia AJ. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. The Journal of Biological Chemistry. 277: 40112-7. PMID 12186875 DOI: 10.1074/Jbc.M206922200  0.96
2002 Hammond EM, Giaccia AJ. Antiangiogenic therapy and p53. Science (New York, N.Y.). 297: 471; discussion 471. PMID 12142499 DOI: 10.1126/Science.297.5581.471A  0.6
2002 Yun Z, Maecker HL, Johnson RS, Giaccia AJ. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Developmental Cell. 2: 331-41. PMID 11879638 DOI: 10.1016/S1534-5807(02)00131-4  0.56
2002 Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. Hypoxia links ATR and p53 through replication arrest. Molecular and Cellular Biology. 22: 1834-43. PMID 11865061 DOI: 10.1128/Mcb.22.6.1834-1843.2002  0.68
2001 Chen EY, Mazure NM, Cooper JA, Giaccia AJ. Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation. Cancer Research. 61: 2429-33. PMID 11289110  0.6
2001 Green SL, Freiberg RA, Giaccia AJ. p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Molecular and Cellular Biology. 21: 1196-206. PMID 11158306 DOI: 10.1128/Mcb.21.4.1196-1206.2001  0.96
2000 Sugawara J, Tazuke SI, Suen LF, Powell DR, Kaper F, Giaccia AJ, Giudice LC. Regulation of insulin-like growth factor-binding protein 1 by hypoxia and 3',5'-cyclic adenosine monophosphate is additive in HepG2 cells. The Journal of Clinical Endocrinology and Metabolism. 85: 3821-7. PMID 11061545 DOI: 10.1210/Jcem.85.10.6866  0.96
2000 Maecker HL, Koumenis C, Giaccia AJ. p53 promotes selection for Fas-mediated apoptotic resistance. Cancer Research. 60: 4638-44. PMID 10969818  0.56
2000 Sugawara J, Suh DS, Faessen GH, Suen LF, Shibata T, Kaper F, Giaccia AJ, Giudice LC. Regulation of insulin-like growth factor-binding protein-1 by nitric oxide under hypoxic conditions. The Journal of Clinical Endocrinology and Metabolism. 85: 2714-21. PMID 10946870 DOI: 10.1210/Jcem.85.8.6709  0.96
2000 Laderoute KR, Alarcon RM, Brody MD, Calaoagan JM, Chen EY, Knapp AM, Yun Z, Denko NC, Giaccia AJ. Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 6: 2941-50. PMID 10914744  0.96
2000 Denko NC, Green SL, Edwards D, Giaccia AJ. p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia. Experimental Cell Research. 258: 82-91. PMID 10912790 DOI: 10.1006/Excr.2000.4928  0.96
2000 Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes & Development. 14: 391-6. PMID 10691731 DOI: 10.1101/Gad.14.4.391  0.96
1999 Chen EY, Fujinaga M, Giaccia AJ. Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Teratology. 60: 215-25. PMID 10508975 DOI: 10.1002/(Sici)1096-9926(199910)60:4<215::Aid-Tera6>3.0.Co;2-2  0.6
1999 Laderoute KR, Mendonca HL, Calaoagan JM, Knapp AM, Giaccia AJ, Stork PJ. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. The Journal of Biological Chemistry. 274: 12890-7. PMID 10212278 DOI: 10.1074/Jbc.274.18.12890  0.96
1998 Spicher A, Guicherit OM, Duret L, Aslanian A, Sanjines EM, Denko NC, Giaccia AJ, Blau HM. Highly conserved RNA sequences that are sensors of environmental stress. Molecular and Cellular Biology. 18: 7371-82. PMID 9819424 DOI: 10.1128/Mcb.18.12.7371  0.96
1998 Green SL, Giaccia AJ. Tumor hypoxia and the cell cycle: implications for malignant progression and response to therapy. The Cancer Journal From Scientific American. 4: 218-23. PMID 9689978  0.96
1997 Mazure NM, Chen EY, Laderoute KR, Giaccia AJ. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood. 90: 3322-31. PMID 9345014 DOI: 10.1182/Blood.V90.9.3322  0.6
1997 Lemmon MJ, van Zijl P, Fox ME, Mauchline ML, Giaccia AJ, Minton NP, Brown JM. Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Therapy. 4: 791-6. PMID 9338007 DOI: 10.1038/Sj.Gt.3300468  0.96
1996 Fried LM, Koumenis C, Peterson SR, Green SL, van Zijl P, Allalunis-Turner J, Chen DJ, Fishel R, Giaccia AJ, Brown JM, Kirchgessner CU. The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction. Proceedings of the National Academy of Sciences of the United States of America. 93: 13825-30. PMID 8943020 DOI: 10.1073/Pnas.93.24.13825  0.96
1996 Mazure NM, Chen EY, Yeh P, Laderoute KR, Giaccia AJ. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Research. 56: 3436-40. PMID 8758908  0.6
1996 Graeber TG, Osmanian C, Jacks T, Housman DE, Koch CJ, Lowe SW, Giaccia AJ. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 379: 88-91. PMID 8538748 DOI: 10.1038/379088A0  0.96
1994 Denko NC, Giaccia AJ, Stringer JR, Stambrook PJ. The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle. Proceedings of the National Academy of Sciences of the United States of America. 91: 5124-8. PMID 8197195 DOI: 10.1073/Pnas.91.11.5124  0.96
1994 Koong AC, Chen EY, Kim CY, Giaccia AJ. Activators of protein kinase C selectively mediate cellular cytotoxicity to hypoxic cells and not aerobic cells. International Journal of Radiation Oncology, Biology, Physics. 29: 259-65. PMID 8195017 DOI: 10.1016/0360-3016(94)90272-0  0.6
1994 Koong AC, Auger EA, Chen EY, Giaccia AJ. The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors. Radiation Research. 138: S60-3. PMID 8146329 DOI: 10.2307/3578763  0.6
1994 Koong AC, Chen EY, Giaccia AJ. Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Research. 54: 1425-30. PMID 8137243  0.6
1994 Koong AC, Chen EY, Lee AS, Brown JM, Giaccia AJ. Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction. International Journal of Radiation Oncology, Biology, Physics. 28: 661-6. PMID 8113109 DOI: 10.1016/0360-3016(94)90191-0  0.6
1994 Graeber TG, Peterson JF, Tsai M, Monica K, Fornace AJ, Giaccia AJ. Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Molecular and Cellular Biology. 14: 6264-77. PMID 8065358 DOI: 10.1128/Mcb.14.9.6264  0.96
1994 Mivechi NF, Koong AC, Giaccia AJ, Hahn GM. Analysis of HSF-1 phosphorylation in A549 cells treated with a variety of stresses. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 10: 371-9. PMID 7930803 DOI: 10.3109/02656739409010281  0.6
1994 Saad AH, Kuo SS, Koong AC, Hahn GM, Giaccia AJ. Modulation of potassium channels by protein tyrosine kinase inhibitors. Journal of Cellular Physiology. 161: 142-8. PMID 7929599 DOI: 10.1002/Jcp.1041610117  0.6
1994 Koong AC, Chen EY, Mivechi NF, Denko NC, Stambrook P, Giaccia AJ. Hypoxic Activation of Nuclear Factor-kB Is Mediated by a Ras and Raf Signaling Pathway and Does Not Involve MAP Kinase (ERK1 or ERK2) Cancer Research. 54: 5273-5279. PMID 7923153  0.96
1993 Kuo SS, Saad AH, Koong AC, Hahn GM, Giaccia AJ. Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells. Proceedings of the National Academy of Sciences of the United States of America. 90: 908-12. PMID 8430104 DOI: 10.1073/Pnas.90.3.908  0.6
1993 Columna EA, Giaccia AJ, Evans JW, Yates BL, Morgan WF. Analysis of restriction enzyme‐induced chromosomal aberrations by fluorescence in situ hybridization Environmental and Molecular Mutagenesis. 22: 26-33. PMID 8393403 DOI: 10.1002/Em.2850220106  0.96
1993 Koong AC, Giaccia AJ, Hahn GM, Saad AH. Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549. Journal of Cellular Physiology. 156: 341-7. PMID 8344990 DOI: 10.1002/Jcp.1041560217  0.6
1993 Auger EA, Giaccia AJ, Hahn GM. Heat sensitivity of bleomycin-sensitive CHO derivatives is not due to improper initialization of heat shock response. International Journal of Hyperthermia : the Official Journal of European Society For Hyperthermic Oncology, North American Hyperthermia Group. 9: 275-84. PMID 7682247 DOI: 10.3109/02656739309022540  0.48
1992 Giaccia AJ, Auger EA, Koong A, Terris DJ, Minchinton AI, Hahn GM, Brown JM. Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro. International Journal of Radiation Oncology, Biology, Physics. 23: 891-7. PMID 1618682 DOI: 10.1016/0360-3016(92)90667-7  0.48
1992 Giaccia AJ, Biedermann KA, Tosto LM, Minchinton AI, Kovacs MS, Brown JM. Characterization of a CHO cell line resistant to killing by the hypoxic cell cytotoxin SR 4233. International Journal of Radiation Oncology, Biology, Physics. 22: 681-4. PMID 1544836 DOI: 10.1016/0360-3016(92)90502-9  0.96
1990 Bahari IB, Bedford JS, Giaccia AJ, Stamato TD. Measurement of the relative proportion of symmetrical and asymmetrical chromosome-type interchanges induced by γ radiation in human-hamster hybrid cells Radiation Research. 123: 105-107. PMID 2371375 DOI: 10.2307/3577665  0.96
1990 Giaccia AJ, MacLaren RA, Denko N, Nicolaou D, Stamato TD. Increased sensitivity to killing by restriction enzymes in the XR-1 DNA double-strand break repair-deficient mutant. Mutation Research. 236: 67-76. PMID 2164147 DOI: 10.1016/0921-8777(90)90034-3  0.6
1989 Giaccia AJ, Richardson E, Denko N, Stamato TD. Genetic analysis of XR-1 mutation in hamster and human hybrids. Somatic Cell and Molecular Genetics. 15: 71-7. PMID 2916163 DOI: 10.1007/Bf01534671  0.32
1989 Denko N, Giaccia A, Peters B, Stamato TD. An asymmetric field inversion gel electrophoresis method for the separation of large DNA molecules. Analytical Biochemistry. 178: 172-6. PMID 2729570 DOI: 10.1016/0003-2697(89)90375-8  0.32
1989 Stamato TD, Richardson E, Ianacone J, MacLaren RA, Denko N, Giaccia A. Isolation and characterization of glucose-6-phosphate dehydrogenase-deficient Chinese hamster cells derived from pure mutant colonies. Mutagenesis. 4: 259-64. PMID 2674604 DOI: 10.1093/Mutage/4.4.259  0.32
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