Stephen M Hedrick - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Cell Biology
Website:
https://biology.ucsd.edu/research/faculty/shedrick

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Allison KA, Sajti E, Collier JG, Gosselin D, Troutman TD, Stone EL, Hedrick SM, Glass CK. Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. Elife. 5. PMID 27376549 DOI: 10.7554/eLife.10134  1
2015 Mah IK, Soloff R, Hedrick SM, Mariani FV. Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway. Stem Cell Reports. PMID 26527382 DOI: 10.1016/j.stemcr.2015.09.021  1
2015 Kang H, Corr M, Mansson R, Welinder E, Hedrick SM, Stone EL. Loss of Murine FOXO3 in Cells of the Myeloid Lineage Enhances Myelopoiesis but Protects from K/BxN-Serum Transfer-Induced Arthritis. Plos One. 10: e0126728. PMID 25969990 DOI: 10.1371/journal.pone.0126728  0.36
2015 Stone EL, Pepper M, Katayama CD, Kerdiles YM, Lai CY, Emslie E, Lin YC, Yang E, Goldrath AW, Li MO, Cantrell DA, Hedrick SM. ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity. 42: 239-51. PMID 25692700 DOI: 10.1016/j.immuni.2015.01.017  1
2015 Kang H, Corr M, Mansson R, Welinder E, Hedrick SM, Stone EL. Loss of murine FOXO3 in cells of the myeloid lineage enhances myelopoiesis but protects from K/BxN-serum transfer-induced arthritis Plos One. 10. DOI: 10.1371/journal.pone.0126728  1
2014 Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick SM, Fehling HJ, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL. Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates. Immunity. 41: 934-46. PMID 25526308 DOI: 10.1016/j.immuni.2014.10.021  1
2014 Mingueneau M, Krishnaswamy S, Spitzer MH, Bendall SC, Stone EL, Hedrick SM, Pe'er D, Mathis D, Nolan GP, Benoist C. Single-cell mass cytometry of TCR signaling: amplification of small initial differences results in low ERK activation in NOD mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 16466-71. PMID 25362052 DOI: 10.1073/pnas.1419337111  1
2014 Roupé KM, Veerla S, Olson J, Stone EL, Sørensen OE, Hedrick SM, Nizet V. Transcription factor binding site analysis identifies FOXO transcription factors as regulators of the cutaneous wound healing process. Plos One. 9: e89274. PMID 24586650 DOI: 10.1371/journal.pone.0089274  1
2013 Ruff LE, Mahmoud EA, Sankaranarayanan J, Morachis JM, Katayama CD, Corr M, Hedrick SM, Almutairi A. Antigen-loaded pH-sensitive hydrogel microparticles are taken up by dendritic cells with no requirement for targeting antibodies. Integrative Biology : Quantitative Biosciences From Nano to Macro. 5: 195-203. PMID 23060228 DOI: 10.1039/c2ib20109g  1
2012 Gu L, Ruff LE, Qin Z, Corr M, Hedrick SM, Sailor MJ. Multivalent porous silicon nanoparticles enhance the immune activation potency of agonistic CD40 antibody. Advanced Materials (Deerfield Beach, Fla.). 24: 3981-7. PMID 22689074 DOI: 10.1002/adma.201200776  1
2012 Chang CF, D'Souza WN, Ch'en IL, Pages G, Pouyssegur J, Hedrick SM. Polar opposites: Erk direction of CD4 T cell subsets. Journal of Immunology (Baltimore, Md. : 1950). 189: 721-31. PMID 22675204 DOI: 10.4049/jimmunol.1103015  0.52
2011 Ch'en IL, Tsau JS, Molkentin JD, Komatsu M, Hedrick SM. Mechanisms of necroptosis in T cells. The Journal of Experimental Medicine. 208: 633-41. PMID 21402742 DOI: 10.1084/jem.20110251  0.32
2010 Kerdiles YM, Stone EL, Beisner DR, Beisner DL, McGargill MA, Ch'en IL, Stockmann C, Katayama CD, Hedrick SM. Foxo transcription factors control regulatory T cell development and function. Immunity. 33: 890-904. PMID 21167754 DOI: 10.1016/j.immuni.2010.12.002  1
2010 Hedrick SM, Ch'en IL, Alves BN. Intertwined pathways of programmed cell death in immunity. Immunological Reviews. 236: 41-53. PMID 20636807 DOI: 10.1111/j.1600-065X.2010.00918.x  1
2010 Soto PC, Stein LL, Hurtado-Ziola N, Hedrick SM, Varki A. Relative over-reactivity of human versus chimpanzee lymphocytes: implications for the human diseases associated with immune activation. Journal of Immunology (Baltimore, Md. : 1950). 184: 4185-95. PMID 20231688 DOI: 10.4049/jimmunol.0903420  1
2009 McGargill MA, Ch'en IL, Katayama CD, Pagès G, Pouysségur J, Hedrick SM. Cutting edge: Extracellular signal-related kinase is not required for negative selection of developing T cells. Journal of Immunology (Baltimore, Md. : 1950). 183: 4838-42. PMID 19801509 DOI: 10.4049/jimmunol.0902208  1
2009 Dejean AS, Beisner DR, Ch'en IL, Kerdiles YM, Babour A, Arden KC, Castrillon DH, DePinho RA, Hedrick SM. Transcription factor Foxo3 controls the magnitude of T cell immune responses by modulating the function of dendritic cells. Nature Immunology. 10: 504-13. PMID 19363483 DOI: 10.1038/ni.1729  1
2009 Kerdiles YM, Beisner DR, Tinoco R, Dejean AS, Castrillon DH, DePinho RA, Hedrick SM. Foxo1 links homing and survival of naive T cells by regulating L-selectin, CCR7 and interleukin 7 receptor. Nature Immunology. 10: 176-84. PMID 19136962 DOI: 10.1038/ni.1689  1
2008 D'Souza WN, Chang CF, Fischer AM, Li M, Hedrick SM. The Erk2 MAPK regulates CD8 T cell proliferation and survival. Journal of Immunology (Baltimore, Md. : 1950). 181: 7617-29. PMID 19017950  1
2008 McGargill MA, Choy C, Wen BG, Hedrick SM. Drak2 regulates the survival of activated T cells and is required for organ-specific autoimmune disease. Journal of Immunology (Baltimore, Md. : 1950). 181: 7593-605. PMID 19017948  1
2008 Ch'en IL, Beisner DR, Degterev A, Lynch C, Yuan J, Hoffmann A, Hedrick SM. Antigen-mediated T cell expansion regulated by parallel pathways of death. Proceedings of the National Academy of Sciences of the United States of America. 105: 17463-8. PMID 18981423 DOI: 10.1073/pnas.0808043105  1
2008 Wang S, Welte T, McGargill M, Town T, Thompson J, Anderson JF, Flavell RA, Fikrig E, Hedrick SM, Wang T. Drak2 contributes to West Nile virus entry into the brain and lethal encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 181: 2084-91. PMID 18641347  1
2008 Ch'en IL, Hedrick SM, Hoffmann A. NF-kappaB as a determinant of distinct cell death pathways. Methods in Enzymology. 446: 175-87. PMID 18603122 DOI: 10.1016/S0076-6879(08)01610-8  0.32
2008 Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chemical Biology. 4: 313-21. PMID 18408713 DOI: 10.1038/nchembio.83  1
2007 Allen JJ, Li M, Brinkworth CS, Paulson JL, Wang D, Hübner A, Chou WH, Davis RJ, Burlingame AL, Messing RO, Katayama CD, Hedrick SM, Shokat KM. A semisynthetic epitope for kinase substrates. Nature Methods. 4: 511-6. PMID 17486086 DOI: 10.1038/nmeth1048  0.52
2007 Peter ME, Budd RC, Desbarats J, Hedrick SM, Hueber AO, Newell MK, Owen LB, Pope RM, Tschopp J, Wajant H, Wallach D, Wiltrout RH, Zörnig M, Lynch DH. The CD95 receptor: apoptosis revisited. Cell. 129: 447-50. PMID 17482535 DOI: 10.1016/j.cell.2007.04.031  1
2006 Broussard C, Fleischacker C, Fleischecker C, Horai R, Chetana M, Venegas AM, Sharp LL, Hedrick SM, Fowlkes BJ, Schwartzberg PL. Altered development of CD8+ T cell lineages in mice deficient for the Tec kinases Itk and Rlk. Immunity. 25: 93-104. PMID 16860760 DOI: 10.1016/j.immuni.2006.05.011  1
2006 D'Souza WN, Hedrick SM. Cutting edge: latecomer CD8 T cells are imprinted with a unique differentiation program. Journal of Immunology (Baltimore, Md. : 1950). 177: 777-81. PMID 16818730  0.52
2005 Fischer AM, Katayama CD, Pagès G, Pouysségur J, Hedrick SM. The role of erk1 and erk2 in multiple stages of T cell development. Immunity. 23: 431-43. PMID 16226508 DOI: 10.1016/j.immuni.2005.08.013  0.52
2005 Friedrich ML, Wen BG, Bain G, Kee BL, Katayama C, Murre C, Hedrick SM, Walsh CM. DRAK2, a lymphoid-enriched DAP kinase, regulates the TCR activation threshold during thymocyte selection. International Immunology. 17: 1379-90. PMID 16172133 DOI: 10.1093/intimm/dxh315  1
2005 Beisner DR, Ch'en IL, Kolla RV, Hoffmann A, Hedrick SM. Cutting edge: innate immunity conferred by B cells is regulated by caspase-8. Journal of Immunology (Baltimore, Md. : 1950). 175: 3469-73. PMID 16148088  0.4
2005 Hedrick SM, Cohen DI, Nielsen EA, Davis MM. Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. 1984. Journal of Immunology (Baltimore, Md. : 1950). 175: 2771-5. PMID 16116160  1
2005 McGargill MA, Sharp LL, Bui JD, Hedrick SM, Calbo S. Active Ca2+/calmodulin-dependent protein kinase II gamma B impairs positive selection of T cells by modulating TCR signaling. Journal of Immunology (Baltimore, Md. : 1950). 175: 656-64. PMID 16002660  1
2005 Catlett IM, Hedrick SM. Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells. Nature Immunology. 6: 715-21. PMID 15924143 DOI: 10.1038/ni1211  0.32
2005 Lin MY, Zal T, Ch'en IL, Gascoigne NR, Hedrick SM. A pivotal role for the multifunctional calcium/calmodulin-dependent protein kinase II in T cells: from activation to unresponsiveness. Journal of Immunology (Baltimore, Md. : 1950). 174: 5583-92. PMID 15843557  0.32
2004 McGargill MA, Wen BG, Walsh CM, Hedrick SM. A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. Immunity. 21: 781-91. PMID 15589167 DOI: 10.1016/j.immuni.2004.10.008  1
2004 Soloff RS, Katayama C, Lin MY, Feramisco JR, Hedrick SM. Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. Journal of Immunology (Baltimore, Md. : 1950). 173: 3250-60. PMID 15322187  1
2003 Beisner DR, Chu IH, Arechiga AF, Hedrick SM, Walsh CM. The requirements for Fas-associated death domain signaling in mature T cell activation and survival. Journal of Immunology (Baltimore, Md. : 1950). 171: 247-56. PMID 12817005  0.4
2003 Brinkman-Van der Linden EC, Angata T, Reynolds SA, Powell LD, Hedrick SM, Varki A. CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice. Molecular and Cellular Biology. 23: 4199-206. PMID 12773563 DOI: 10.1128/MCB.23.12.4199-4206.2003  1
2002 Mertsching E, Wurster AL, Katayama C, Esko J, Ramsdell F, Marth JD, Hedrick SM. A mouse strain defective for alphabeta versus gammadelta T cell lineage commitment. International Immunology. 14: 1039-53. PMID 12202401 DOI: 10.1093/intimm/dxf067  1
2002 Onami TM, Lin MY, Page DM, Reynolds SA, Katayama CD, Marth JD, Irimura T, Varki A, Varki N, Hedrick SM. Generation of mice deficient for macrophage galactose- and N-acetylgalactosamine-specific lectin: limited role in lymphoid and erythroid homeostasis and evidence for multiple lectins. Molecular and Cellular Biology. 22: 5173-81. PMID 12077344 DOI: 10.1128/MCB.22.14.5173-5181.2002  1
2001 Bain G, Cravatt CB, Loomans C, Alberola-Ila J, Hedrick SM, Murre C. Regulation of the helix-loop-helix proteins, E2A and Id3, by the Ras-ERK MAPK cascade. Nature Immunology. 2: 165-71. PMID 11175815 DOI: 10.1038/84273  1
2000 Jepsen K, Hermanson O, Onami TM, Gleiberman AS, Lunyak V, McEvilly RJ, Kurokawa R, Kumar V, Liu F, Seto E, Hedrick SM, Mandel G, Glass CK, Rose DW, Rosenfeld MG. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell. 102: 753-63. PMID 11030619 DOI: 10.1016/S0092-8674(00)00064-7  1
2000 Bui JD, Calbo S, Hayden-Martinez K, Kane LP, Gardner P, Hedrick SM. A role for CaMKII in T cell memory. Cell. 100: 457-67. PMID 10693762 DOI: 10.1016/S0092-8674(00)80681-9  1
1999 Bain G, Quong MW, Soloff RS, Hedrick SM, Murre C. Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47. The Journal of Experimental Medicine. 190: 1605-16. PMID 10587351 DOI: 10.1084/jem.190.11.1605  1
1998 Schwarz DA, Katayama CD, Hedrick SM. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity. 9: 657-68. PMID 9846487 DOI: 10.1016/S1074-7613(00)80663-9  0.32
1998 Walsh CM, Wen BG, Chinnaiyan AM, O'Rourke K, Dixit VM, Hedrick SM. A role for FADD in T cell activation and development Immunity. 8: 439-449. PMID 9586634 DOI: 10.1016/S1074-7613(00)80549-X  1
1997 Weintraub BC, Eckmann L, Okamoto S, Hense M, Hedrick SM, Fierer J. Role of alphabeta and gammadelta T cells in the host response to Salmonella infection as demonstrated in T-cell-receptor-deficient mice of defined Ity genotypes. Infection and Immunity. 65: 2306-12. PMID 9169768 DOI: 10.1128/iai.65.6.2306-2312.1997  1
1996 Matechak EO, Killeen N, Hedrick SM, Fowlkes BJ. MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent Immunity. 4: 337-347. PMID 8612128 DOI: 10.1016/S1074-7613(00)80247-2  1
1995 Weintraub BC, Hedrick SM. The enigmatic specificity of gamma delta T cells. Immunologic Research. 14: 163-75. PMID 8778207 DOI: 10.1007/BF02918214  1
1995 Duncan DD, Stupakoff A, Hedrick SM, Marcu KB, Siu G. A Myc-associated zinc finger protein binding site is one of four important functional regions in the CD4 promoter Molecular and Cellular Biology. 15: 3179-3186. PMID 7760814  1
1995 Foy TM, Page DM, Waldschmidt TJ, Schoneveld A, Laman JD, Masters SR, Tygrett L, Ledbetter JA, Aruffo A, Claassen E, Xu JC, Flavell RA, Oehen S, Hedrick SM, Noelle RJ. An essential role for gp39, the ligand for CD40, in thymic selection. The Journal of Experimental Medicine. 182: 1377-88. PMID 7595208 DOI: 10.1084/jem.182.5.1377  1
1994 Siu G, Wurster AL, Duncan DD, Soliman TM, Hedrick SM. A transcriptional silencer controls the developmental expression of the CD4 gene. The Embo Journal. 13: 3570-9. PMID 8062832  1
1994 Wurster AL, Siu G, Leiden JM, Hedrick SM. Elf-1 binds to a critical element in a second CD4 enhancer. Molecular and Cellular Biology. 14: 6452-63. PMID 7935370  1
1994 Vasquez NJ, Kane LP, Hedrick SM. Intracellular signals that mediate thymic negative selection. Immunity. 1: 45-56. PMID 7889398 DOI: 10.1016/1074-7613(94)90008-6  1
1993 Penninger J, Kishihara K, Molina T, Wallace VA, Timms E, Hedrick SM, Mak TW. Requirement for tyrosine kinase p56lck for thymic development of transgenic gamma delta T cells. Science (New York, N.Y.). 260: 358-61. PMID 8469988 DOI: 10.1126/science.8469988  1
1993 Dent AL, Matis LA, Bluestone JA, Hedrick SM. Evidence for programmed cell death of self-reactive γδ T cell receptor-positive thymocytes European Journal of Immunology. 23: 2482-2487. PMID 8405049 DOI: 10.1002/eji.1830231016  1
1992 Barrett TA, Delvy ML, Kennedy DM, Lefrancois L, Matis LA, Dent AL, Hedrick SM, Bluestone JA. Mechanism of self-tolerance of gamma/delta T cells in epithelial tissue. The Journal of Experimental Medicine. 175: 65-70. PMID 1730927 DOI: 10.1084/jem.175.1.65  1
1992 Siu G, Wurster AL, Lipsick JS, Hedrick SM. Expression of the CD4 gene requires a Myb transcription factor Molecular and Cellular Biology. 12: 1592-1604. PMID 1347906  1
1990 Hedrick SM, Dent A. A model for γδ T-cell development: Rearranged γ- and δ-chain genes incorporated into the germline of mice Research in Immunology. 141: 588-592. PMID 2095602 DOI: 10.1016/0923-2494(90)90061-3  1
1989 Kaye J, Hsu ML, Sauron ME, Jameson SC, Gascoigne NR, Hedrick SM. Selective development of CD4+ T cells in transgenic mice expressing a class II MHC-restricted antigen receptor. Nature. 341: 746-9. PMID 2571940 DOI: 10.1038/341746a0  1
1989 Becker ML, Near R, Mudgett-Hunter M, Margolies MN, Kubo RT, Kaye J, Hedrick SM. Expression of a hybrid immunoglobulin-T cell receptor protein in transgenic mice. Cell. 58: 911-21. PMID 2528411 DOI: 10.1016/0092-8674(89)90943-4  1
1985 Cohen DI, Hedrick SM, Nielsen EA, D'Eustachio P, Ruddle F, Steinberg AD, Paul WE, Davis MM. Isolation of a cDNA clone corresponding to an X-linked gene family (XLR) closely linked to the murine immunodeficiency disorder xid. Nature. 314: 369-72. PMID 2984575 DOI: 10.1038/314369a0  0.16
1984 Davis MM, Chien YH, Gascoigne NR, Hedrick SM. A murine T cell receptor gene complex: isolation, structure and rearrangement Immunological Reviews. 81: 235-258. PMID 6096259  1
1980 Hedrick SM, Watson JD. Genetic control of the immune response to collagen. I. Quantitative determination of response levels by multiple I-region genes Journal of Immunogenetics. 7: 271-283. PMID 6774029  1
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