| Year |
Citation |
Score |
| 2018 |
Thompson JL, Zhao Y, Stathopulos PB, Grossfield A, Shuttleworth TJ. Phosphorylation-mediated structural changes within the SOAR domain of STIM1 enable specific activation of distinct Orai channels. The Journal of Biological Chemistry. PMID 29326165 DOI: 10.1074/Jbc.M117.819078 |
0.399 |
|
| 2016 |
Shuttleworth TJ. Selective activation of distinct Orai channels by STIM1. Cell Calcium. PMID 27847114 DOI: 10.1016/J.Ceca.2016.11.001 |
0.362 |
|
| 2015 |
Thompson JL, Shuttleworth TJ. Anchoring protein AKAP79-mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store-independent Orai channel. The Journal of Physiology. 593: 559-72. PMID 25504574 DOI: 10.1113/Jphysiol.2014.284182 |
0.452 |
|
| 2014 |
Duquette M, Nadler M, Okuhara D, Thompson J, Shuttleworth T, Lawler J. Members of the thrombospondin gene family bind stromal interaction molecule 1 and regulate calcium channel activity. Matrix Biology : Journal of the International Society For Matrix Biology. 37: 15-24. PMID 24845346 DOI: 10.1016/J.Matbio.2014.05.004 |
0.367 |
|
| 2013 |
Thompson JL, Shuttleworth TJ. Exploring the unique features of the ARC channel, a store-independent Orai channel. Channels (Austin, Tex.). 7: 364-73. PMID 24025406 DOI: 10.4161/Chan.26156 |
0.424 |
|
| 2013 |
Thompson JL, Mignen O, Shuttleworth TJ. The ARC channel--an endogenous store-independent Orai channel. Current Topics in Membranes. 71: 125-48. PMID 23890114 DOI: 10.1016/B978-0-12-407870-3.00006-8 |
0.414 |
|
| 2013 |
Thompson JL, Shuttleworth TJ. How many Orai's does it take to make a CRAC channel? Scientific Reports. 3: 1961. PMID 23743658 DOI: 10.1038/Srep01961 |
0.404 |
|
| 2013 |
Thompson JL, Shuttleworth TJ. Molecular basis of activation of the arachidonate-regulated Ca2+ (ARC) channel, a store-independent Orai channel, by plasma membrane STIM1. The Journal of Physiology. 591: 3507-23. PMID 23690558 DOI: 10.1113/Jphysiol.2013.256784 |
0.448 |
|
| 2012 |
Thompson JL, Shuttleworth TJ. A plasma membrane-targeted cytosolic domain of STIM1 selectively activates ARC channels, an arachidonate-regulated store-independent Orai channel. Channels (Austin, Tex.). 6: 370-8. PMID 22992514 DOI: 10.4161/Chan.21947 |
0.408 |
|
| 2012 |
Shuttleworth TJ. Orai channels - new insights, new ideas. The Journal of Physiology. 590: 4155-6. PMID 22962035 DOI: 10.1113/Jphysiol.2012.237552 |
0.532 |
|
| 2012 |
Palk L, Sneyd J, Patterson K, Shuttleworth TJ, Yule DI, Maclaren O, Crampin EJ. Modelling the effects of calcium waves and oscillations on saliva secretion. Journal of Theoretical Biology. 305: 45-53. PMID 22521411 DOI: 10.1016/J.Jtbi.2012.04.009 |
0.523 |
|
| 2012 |
Shuttleworth TJ. STIM and Orai proteins and the non-capacitative ARC channels. Frontiers in Bioscience (Landmark Edition). 17: 847-60. PMID 22201777 DOI: 10.2741/3960 |
0.413 |
|
| 2012 |
Shuttleworth TJ. Orai3--the 'exceptional' Orai? The Journal of Physiology. 590: 241-57. PMID 22041188 DOI: 10.1113/Jphysiol.2011.220574 |
0.461 |
|
| 2012 |
Thompson JL, Shuttleworth TJ. Activation of ARC Channels, a Noncapacitative Orai Channel, is Independent of the N-Terminal Domains of STIM1 Biophysical Journal. 102: 425a. DOI: 10.1016/J.Bpj.2011.11.2324 |
0.441 |
|
| 2011 |
Thompson JL, Shuttleworth TJ. Orai channel-dependent activation of phospholipase C-δ: a novel mechanism for the effects of calcium entry on calcium oscillations. The Journal of Physiology. 589: 5057-69. PMID 21878525 DOI: 10.1113/Jphysiol.2011.214437 |
0.398 |
|
| 2010 |
Thompson J, Mignen O, Shuttleworth TJ. The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid. Channels (Austin, Tex.). 4: 398-410. PMID 20818184 DOI: 10.4161/Chan.4.5.13226 |
0.483 |
|
| 2010 |
Palk L, Sneyd J, Shuttleworth TJ, Yule DI, Crampin EJ. A dynamic model of saliva secretion. Journal of Theoretical Biology. 266: 625-40. PMID 20600135 DOI: 10.1016/J.Jtbi.2010.06.027 |
0.488 |
|
| 2010 |
Shuttleworth T, Mignen O, Thompson J. Orai3 and the Selective Activation of the Arc Channel by Arachidonic Acid Biophysical Journal. 98: 96a-97a. DOI: 10.1016/J.Bpj.2009.12.544 |
0.43 |
|
| 2009 |
Mignen O, Thompson JL, Shuttleworth TJ. The molecular architecture of the arachidonate-regulated Ca2+-selective ARC channel is a pentameric assembly of Orai1 and Orai3 subunits. The Journal of Physiology. 587: 4181-97. PMID 19622606 DOI: 10.1113/Jphysiol.2009.174193 |
0.468 |
|
| 2009 |
Shuttleworth TJ. Arachidonic acid, ARC channels, and Orai proteins. Cell Calcium. 45: 602-10. PMID 19278724 DOI: 10.1016/J.Ceca.2009.02.001 |
0.432 |
|
| 2009 |
Thompson JL, Mignen O, Shuttleworth TJ. The Orai1 severe combined immune deficiency mutation and calcium release-activated Ca2+ channel function in the heterozygous condition. The Journal of Biological Chemistry. 284: 6620-6. PMID 19075015 DOI: 10.1074/Jbc.M808346200 |
0.462 |
|
| 2008 |
Mignen O, Thompson JL, Shuttleworth TJ. Orai1 subunit stoichiometry of the mammalian CRAC channel pore. The Journal of Physiology. 586: 419-25. PMID 18006576 DOI: 10.1113/Jphysiol.2007.147249 |
0.53 |
|
| 2008 |
Mignen O, Thompson JL, Shuttleworth TJ. Both Orai1 and Orai3 are essential components of the arachidonate-regulated Ca2+-selective (ARC) channels. The Journal of Physiology. 586: 185-95. PMID 17991693 DOI: 10.1113/Jphysiol.2007.146258 |
0.498 |
|
| 2007 |
Gin E, Crampin EJ, Brown DA, Shuttleworth TJ, Yule DI, Sneyd J. A mathematical model of fluid secretion from a parotid acinar cell. Journal of Theoretical Biology. 248: 64-80. PMID 17559884 DOI: 10.1016/J.Jtbi.2007.04.021 |
0.379 |
|
| 2007 |
Shuttleworth TJ, Thompson JL, Mignen O. STIM1 and the noncapacitative ARC channels. Cell Calcium. 42: 183-91. PMID 17391754 DOI: 10.1016/J.Ceca.2007.01.012 |
0.568 |
|
| 2007 |
Mignen O, Thompson JL, Shuttleworth TJ. STIM1 regulates Ca2+ entry via arachidonate-regulated Ca2+-selective (ARC) channels without store depletion or translocation to the plasma membrane. The Journal of Physiology. 579: 703-15. PMID 17158173 DOI: 10.1113/Jphysiol.2006.122432 |
0.56 |
|
| 2006 |
Shuttleworth TJ, Thompson J, Munger RS, Wood CM. A critical analysis of carbonic anhydrase function, respiratory gas exchange, and the acid-base control of secretion in the rectal gland of Squalus acanthias. The Journal of Experimental Biology. 209: 4701-16. PMID 17114403 DOI: 10.1242/Jeb.02564 |
0.419 |
|
| 2005 |
Mignen O, Brink C, Enfissi A, Nadkarni A, Shuttleworth TJ, Giovannucci DR, Capiod T. Carboxyamidotriazole-induced inhibition of mitochondrial calcium import blocks capacitative calcium entry and cell proliferation in HEK-293 cells. Journal of Cell Science. 118: 5615-23. PMID 16306224 DOI: 10.1242/Jcs.02663 |
0.332 |
|
| 2005 |
Mignen O, Thompson JL, Shuttleworth TJ. Arachidonate-regulated Ca2+-selective (ARC) channel activity is modulated by phosphorylation and involves an A-kinase anchoring protein. The Journal of Physiology. 567: 787-98. PMID 15994185 DOI: 10.1113/Jphysiol.2005.090209 |
0.469 |
|
| 2005 |
Mignen O, Thompson JL, Yule DI, Shuttleworth TJ. Agonist activation of arachidonate-regulated Ca2+-selective (ARC) channels in murine parotid and pancreatic acinar cells. The Journal of Physiology. 564: 791-801. PMID 15760932 DOI: 10.1113/Jphysiol.2005.085704 |
0.579 |
|
| 2005 |
Melvin JE, Yule D, Shuttleworth T, Begenisich T. Regulation of fluid and electrolyte secretion in salivary gland acinar cells. Annual Review of Physiology. 67: 445-69. PMID 15709965 DOI: 10.1146/Annurev.Physiol.67.041703.084745 |
0.527 |
|
| 2005 |
Tsaneva-Atanasova K, Shuttleworth TJ, Yule DI, Thompson JL, Sneyd J. Calcium Oscillations and Membrane Transport: The Importance of Two Time Scales Multiscale Modeling & Simulation. 3: 245-264. DOI: 10.1137/030602472 |
0.448 |
|
| 2004 |
Shuttleworth TJ, Thompson JL, Mignen O. ARC channels: a novel pathway for receptor-activated calcium entry. Physiology (Bethesda, Md.). 19: 355-61. PMID 15546853 DOI: 10.1152/Physiol.00018.2004 |
0.581 |
|
| 2004 |
Shuttleworth TJ. Receptor-activated calcium entry channels--who does what, and when? Science's Stke : Signal Transduction Knowledge Environment. 2004: pe40. PMID 15280582 DOI: 10.1126/Stke.2432004Pe40 |
0.533 |
|
| 2004 |
Sneyd J, Tsaneva-Atanasova K, Yule DI, Thompson JL, Shuttleworth TJ. Control of calcium oscillations by membrane fluxes. Proceedings of the National Academy of Sciences of the United States of America. 101: 1392-6. PMID 14734814 DOI: 10.1073/Pnas.0303472101 |
0.5 |
|
| 2004 |
Bruce JI, Giovannucci DR, Blinder G, Shuttleworth TJ, Yule DI. Modulation of [Ca2+]i signaling dynamics and metabolism by perinuclear mitochondria in mouse parotid acinar cells. The Journal of Biological Chemistry. 279: 12909-17. PMID 14699167 DOI: 10.1074/Jbc.M309070200 |
0.495 |
|
| 2004 |
Shuttleworth TJ, Mignen O. Calcium entry and the control of calcium oscillations. Biochemical Society Transactions. 31: 916-9. PMID 14505448 DOI: 10.1042/Bst0310916 |
0.578 |
|
| 2003 |
Mignen O, Thompson JL, Shuttleworth TJ. Calcineurin directs the reciprocal regulation of calcium entry pathways in nonexcitable cells. The Journal of Biological Chemistry. 278: 40088-96. PMID 12874277 DOI: 10.1074/Jbc.M306365200 |
0.571 |
|
| 2003 |
Mignen O, Thompson JL, Shuttleworth TJ. Ca2+ selectivity and fatty acid specificity of the noncapacitative, arachidonate-regulated Ca2+ (ARC) channels. The Journal of Biological Chemistry. 278: 10174-81. PMID 12522216 DOI: 10.1074/Jbc.M212536200 |
0.556 |
|
| 2002 |
Bruce JI, Yule DI, Shuttleworth TJ. Ca2+-dependent protein kinase--a modulation of the plasma membrane Ca2+-ATPase in parotid acinar cells. The Journal of Biological Chemistry. 277: 48172-81. PMID 12368283 DOI: 10.1074/Jbc.M208393200 |
0.539 |
|
| 2002 |
Giovannucci DR, Bruce JI, Straub SV, Arreola J, Sneyd J, Shuttleworth TJ, Yule DI. Cytosolic Ca(2+) and Ca(2+)-activated Cl(-) current dynamics: insights from two functionally distinct mouse exocrine cells. The Journal of Physiology. 540: 469-84. PMID 11956337 DOI: 10.1113/Jphysiol.2001.013453 |
0.542 |
|
| 2002 |
Bruce JI, Shuttleworth TJ, Giovannucci DR, Yule DI. Phosphorylation of inositol 1,4,5-trisphosphate receptors in parotid acinar cells. A mechanism for the synergistic effects of cAMP on Ca2+ signaling. The Journal of Biological Chemistry. 277: 1340-8. PMID 11694504 DOI: 10.1074/Jbc.M106609200 |
0.54 |
|
| 2001 |
Mignen O, Thompson JL, Shuttleworth TJ. Reciprocal regulation of capacitative and arachidonate-regulated noncapacitative Ca2+ entry pathways. The Journal of Biological Chemistry. 276: 35676-83. PMID 11470795 DOI: 10.1074/Jbc.M105626200 |
0.576 |
|
| 2001 |
Mignen O, Shuttleworth TJ. Permeation of monovalent cations through the non-capacitative arachidonate-regulated Ca2+ channels in HEK293 cells. Comparison with endogenous store-operated channels. The Journal of Biological Chemistry. 276: 21365-74. PMID 11285268 DOI: 10.1074/Jbc.M102311200 |
0.524 |
|
| 2000 |
Mignen O, Shuttleworth TJ. I(ARC), a novel arachidonate-regulated, noncapacitative Ca(2+) entry channel. The Journal of Biological Chemistry. 275: 9114-9. PMID 10734044 DOI: 10.1074/Jbc.275.13.9114 |
0.567 |
|
| 2000 |
Osterhout JL, Shuttleworth TJ. A Ca(2+)-independent activation of a type IV cytosolic phospholipase A(2) underlies the receptor stimulation of arachidonic acid-dependent noncapacitative calcium entry. The Journal of Biological Chemistry. 275: 8248-54. PMID 10713151 DOI: 10.1074/Jbc.275.11.8248 |
0.731 |
|
| 1999 |
Shuttleworth TJ, Thompson JL. Discriminating between capacitative and arachidonate-activated Ca(2+) entry pathways in HEK293 cells. The Journal of Biological Chemistry. 274: 31174-8. PMID 10531309 DOI: 10.1074/Jbc.274.44.31174 |
0.55 |
|
| 1999 |
Shuttleworth TJ. What drives calcium entry during [Ca2+]i oscillations?--challenging the capacitative model. Cell Calcium. 25: 237-46. PMID 10378085 DOI: 10.1054/Ceca.1999.0022 |
0.539 |
|
| 1999 |
Shuttleworth TJ, Hildebrandt JP. Vertebrate salt glands: short- and long-term regulation of function. The Journal of Experimental Zoology. 283: 689-701. PMID 10222591 DOI: 10.1002/(Sici)1097-010X(19990601)283:7<689::Aid-Jez7>3.0.Co;2-T |
0.424 |
|
| 1999 |
Shuttleworth TJ, Thompson JL. Muscarinic receptor activation of arachidonate-mediated Ca2+ entry in HEK293 cells is independent of phospholipase C. The Journal of Biological Chemistry. 273: 32636-43. PMID 9830003 DOI: 10.1074/Jbc.273.49.32636 |
0.55 |
|
| 1996 |
Wu JV, Shuttleworth TJ, Stampe P. Clustered distribution of calcium sensitivities: an indication of hetero-tetrameric gating components in Ca2+-activated K+ channels reconstituted from avian nasal gland cells. The Journal of Membrane Biology. 154: 275-82. PMID 8952957 DOI: 10.1007/S002329900152 |
0.405 |
|
| 1996 |
Shuttleworth TJ. Arachidonic acid activates the noncapacitative entry of Ca2+ during [Ca2+]i oscillations. The Journal of Biological Chemistry. 271: 21720-5. PMID 8702966 DOI: 10.1074/Jbc.271.36.21720 |
0.549 |
|
| 1996 |
Shuttleworth TJ, Thompson JL. Evidence for a non-capacitative Ca2+ entry during [Ca2+] oscillations. The Biochemical Journal. 819-24. PMID 8670157 DOI: 10.1042/Bj3160819 |
0.537 |
|
| 1996 |
Shuttleworth TJ, Thompson JL. Ca2+ entry modulates oscillation frequency by triggering Ca2+ release. The Biochemical Journal. 815-9. PMID 8611160 DOI: 10.1042/Bj3130815 |
0.493 |
|
| 1996 |
Shuttleworth TJ. A re-evaluation of the apparent effects of luminal Ca2+ on inositol 1,4,5-trisphosphate-induced Ca2+ release. Cell Calcium. 17: 393-8. PMID 8521453 DOI: 10.1016/0143-4160(95)90085-3 |
0.498 |
|
| 1995 |
Martin SC, Shuttleworth TJ. Activation by ATP of a P(2U) 'nucleotide' receptor in an exocrine cell British Journal of Pharmacology. 115: 321-329. PMID 7670734 DOI: 10.1111/J.1476-5381.1995.Tb15880.X |
0.428 |
|
| 1994 |
Martin SC, Shuttleworth TJ. Muscarinic-receptor activation stimulates oscillations in K+ and Cl- currents which are acutely dependent on extracellular Ca2+ in avian salt gland cells PflüGers Archiv European Journal of Physiology. 426: 231-238. PMID 8183633 DOI: 10.1007/Bf00374776 |
0.521 |
|
| 1994 |
Shuttleworth TJ. Temporal relationships between Ca2+ store mobilization and Ca2+ entry in an exocrine cell. Cell Calcium. 15: 457-66. PMID 8082129 DOI: 10.1016/0143-4160(94)90110-4 |
0.538 |
|
| 1994 |
Martin SC, Thompson J, Shuttleworth TJ. Potentiation of Ca2+-activated secretory activity by a cAMP-mediated mechanism in avian salt gland cells American Journal of Physiology - Cell Physiology. 267. PMID 8048486 DOI: 10.1152/Ajpcell.1994.267.1.C255 |
0.412 |
|
| 1994 |
Martin SC, Shuttleworth TJ. Ca2+ influx drives agonist-activated [Ca2+]i oscillations in an exocrine cell Febs Letters. 352: 32-36. PMID 7925936 DOI: 10.1016/0014-5793(94)00913-9 |
0.522 |
|
| 1994 |
Martin SC, Shuttleworth TJ. Vasoactive intestinal peptide stimulates a cAMP-mediated Cl- current in avian salt gland cells Regulatory Peptides. 52: 205-214. PMID 7800853 DOI: 10.1016/0167-0115(94)90055-8 |
0.384 |
|
| 1993 |
Hildebrandt JP, Shuttleworth TJ. A Gq-type G protein couples muscarinic receptors to inositol phosphate and calcium signaling in exocrine cells from the avian salt gland. The Journal of Membrane Biology. 133: 183-90. PMID 8515432 DOI: 10.1007/Bf00233798 |
0.328 |
|
| 1993 |
Shuttleworth TJ, Thompson JL. Modulation of inositol(1,4,5)trisphosphate-sensitive calcium store content during continuous receptor activation and its effects on calcium entry. Cell Calcium. 13: 541-51. PMID 1334808 DOI: 10.1016/0143-4160(92)90034-P |
0.544 |
|
| 1992 |
Hildebrandt JP, Shuttleworth TJ. Calcium-sensitivity of inositol 1,4,5-trisphosphate metabolism in exocrine cells from the avian salt gland. The Biochemical Journal. 703-10. PMID 1313230 DOI: 10.1042/Bj2820703 |
0.461 |
|
| 1991 |
Hildebrandt JP, Shuttleworth TJ. Inositol phosphates and [Ca2+]i signals in a differentiating exocrine cell. The American Journal of Physiology. 261: C210-7. PMID 1872367 DOI: 10.1152/Ajpcell.1991.261.2.C210 |
0.505 |
|
| 1990 |
Shuttleworth TJ, Thompson JL. Intracellular [Ca2+] and inositol phosphates in avian nasal gland cells. The American Journal of Physiology. 257: C1020-9. PMID 2596581 DOI: 10.1152/Ajpcell.1989.257.5.C1020 |
0.539 |
|
| 1990 |
Shuttleworth TJ. Fluoroaluminate activation of different components of the calcium signal in an exocrine cell. The Biochemical Journal. 269: 417-22. PMID 2386484 DOI: 10.1042/Bj2690417 |
0.544 |
|
| 1990 |
Shuttleworth TJ. Receptor-activated calcium entry in exocrine cells does not occur via agonist-sensitive intracellular pools. The Biochemical Journal. 266: 719-26. PMID 2327960 DOI: 10.1042/Bj2660719 |
0.549 |
|
| 1987 |
Shuttleworth TJ, Thompson JL. Secretory activity in salt glands of birds and turtles: stimulation via cyclic AMP. The American Journal of Physiology. 252: R428-32. PMID 3028184 DOI: 10.1152/Ajpregu.1987.252.2.R428 |
0.35 |
|
| 1986 |
Davis MS, Shuttleworth TJ. Mode of adrenergic and peptidergic inhibition of ion transport in flounder gill. The American Journal of Physiology. 251: R1064-70. PMID 2878620 DOI: 10.1152/Ajpregu.1986.251.6.R1064 |
0.311 |
|
| 1985 |
Davis MS, Shuttleworth TJ. Peptidergic and adrenergic regulation of electrogenic ion transport in isolated gills of the flounder (Platichthys flesus L.) Journal of Comparative Physiology B. 155: 471-478. DOI: 10.1007/Bf00684677 |
0.336 |
|
| 1984 |
Shuttleworth TJ. Role of calcium in cAMP-mediated effects in the elasmobranch rectal gland. The American Journal of Physiology. 245: R894-900. PMID 6318578 DOI: 10.1152/Ajpregu.1983.245.6.R894 |
0.329 |
|
| 1980 |
Shuttleworth TJ, Thompson JL. The mechanism of cyclic AMP stimulation of secretion in the dogfish rectal gland Journal of Comparative Physiology ? B. 140: 209-216. DOI: 10.1007/Bf00690405 |
0.378 |
|
| 1974 |
Shuttleworth TJ, Freeman RFH. Factors affecting the net fluxes of ions in the isolated perfused gills of freshwaterAnguilla dieffenbachii Journal of Comparative Physiology ? B. 94: 297-307. DOI: 10.1007/Bf00710642 |
0.302 |
|
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