William C. Skarnes - Publications

University of California, Berkeley, Berkeley, CA 
Molecular Biology, Cell Biology, Animal Physiology Biology

49/98 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, ... ... Skarnes WC, et al. High-throughput discovery of novel developmental phenotypes. Nature. PMID 27626380 DOI: 10.1038/nature19356  0.36
2016 Panamarova M, Cox A, Wicher K, Butler R, Bulgakova N, Jeon S, Rosen B, Seong RH, Skarnes W, Crabtree G, Zernicka-Goetz M. BAF chromatin remodelling complex is an epigenetic regulator of lineage specification in the early mouse embryo. Development (Cambridge, England). PMID 26952987 DOI: 10.1242/dev.131961  0.36
2015 Coelho PA, Bury L, Shahbazi MN, Liakath-Ali K, Tate PH, Wormald S, Hindley CJ, Huch M, Archer J, Skarnes WC, Zernicka-Goetz M, Glover DM. Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse. Open Biology. 5. PMID 26701933 DOI: 10.1098/rsob.150209  0.36
2015 Denning C, Borgdorff V, Crutchley J, Firth KS, George V, Kalra S, Kondrashov A, Hoang MD, Mosqueira D, Patel A, Prodanov L, Rajamohan D, Skarnes WC, Smith JG, Young LE. Cardiomyocytes from human pluripotent stem cells: From laboratory curiosity to industrial biomedical platform. Biochimica Et Biophysica Acta. PMID 26524115 DOI: 10.1016/j.bbamcr.2015.10.014  0.36
2015 Iyer V, Shen B, Zhang W, Hodgkins A, Keane T, Huang X, Skarnes WC. Off-target mutations are rare in Cas9-modified mice. Nature Methods. 12: 479. PMID 26020497 DOI: 10.1038/nmeth.3408  0.36
2015 Hodgkins A, Farne A, Perera S, Grego T, Parry-Smith DJ, Skarnes WC, Iyer V. WGE: a CRISPR database for genome engineering. Bioinformatics (Oxford, England). 31: 3078-80. PMID 25979474 DOI: 10.1093/bioinformatics/btv308  0.36
2015 Yeung AT, Hale C, Xia J, Tate PH, Goulding D, Keane JA, Mukhopadhyay S, Forrester L, Billker O, Skarnes WC, Hancock RE, Dougan G. Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function. Scientific Reports. 5: 8908. PMID 25752829 DOI: 10.1038/srep08908  0.36
2014 Shen B, Zhang W, Zhang J, Zhou J, Wang J, Chen L, Wang L, Hodgkins A, Iyer V, Huang X, Skarnes WC. Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects. Nature Methods. 11: 399-402. PMID 24584192 DOI: 10.1038/nmeth.2857  0.36
2014 Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, ... ... Skarnes WC, et al. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic Acids Research. 42: D802-9. PMID 24194600 DOI: 10.1093/nar/gkt977  0.36
2013 Ryder E, Gleeson D, Sethi D, Vyas S, Miklejewska E, Dalvi P, Habib B, Cook R, Hardy M, Jhaveri K, Bottomley J, Wardle-Jones H, Bussell JN, Houghton R, Salisbury J, ... Skarnes WC, et al. Molecular characterization of mutant mouse strains generated from the EUCOMM/KOMP-CSD ES cell resource. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 24: 286-94. PMID 23912999 DOI: 10.1007/s00335-013-9467-x  0.36
2013 White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, ... ... Skarnes WC, et al. Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell. 154: 452-64. PMID 23870131 DOI: 10.1016/j.cell.2013.06.022  0.36
2012 Mallon AM, Iyer V, Melvin D, Morgan H, Parkinson H, Brown SD, Flicek P, Skarnes WC. Accessing data from the International Mouse Phenotyping Consortium: state of the art and future plans. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 641-52. PMID 22991088 DOI: 10.1007/s00335-012-9428-9  0.36
2012 Bradley A, Anastassiadis K, Ayadi A, Battey JF, Bell C, Birling MC, Bottomley J, Brown SD, Bürger A, Bult CJ, Bushell W, Collins FS, Desaintes C, Doe B, Economides A, ... ... Skarnes WC, et al. The mammalian gene function resource: the International Knockout Mouse Consortium. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 580-6. PMID 22968824 DOI: 10.1007/s00335-012-9422-2  0.36
2012 Ayadi A, Birling MC, Bottomley J, Bussell J, Fuchs H, Fray M, Gailus-Durner V, Greenaway S, Houghton R, Karp N, Leblanc S, Lengger C, Maier H, Mallon AM, Marschall S, ... ... Skarnes WC, et al. Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 23: 600-10. PMID 22961258 DOI: 10.1007/s00335-012-9418-y  0.36
2012 Davis MP, Abreu-Goodger C, van Dongen S, Lu D, Tate PH, Bartonicek N, Kutter C, Liu P, Skarnes WC, Enright AJ, Dunham I. Large-scale identification of microRNA targets in murine Dgcr8-deficient embryonic stem cell lines. Plos One. 7: e41762. PMID 22912678 DOI: 10.1371/journal.pone.0041762  0.36
2012 Lu D, Davis MP, Abreu-Goodger C, Wang W, Campos LS, Siede J, Vigorito E, Skarnes WC, Dunham I, Enright AJ, Liu P. MiR-25 regulates Wwp2 and Fbxw7 and promotes reprogramming of mouse fibroblast cells to iPSCs. Plos One. 7: e40938. PMID 22912667 DOI: 10.1371/journal.pone.0040938  0.36
2011 Pfander C, Anar B, Schwach F, Otto TD, Brochet M, Volkmann K, Quail MA, Pain A, Rosen B, Skarnes W, Rayner JC, Billker O. A scalable pipeline for highly effective genetic modification of a malaria parasite. Nature Methods. 8: 1078-82. PMID 22020067 DOI: 10.1038/nmeth.1742  0.36
2011 Oakley DJ, Iyer V, Skarnes WC, Smedley D. BioMart as an integration solution for the International Knockout Mouse Consortium. Database : the Journal of Biological Databases and Curation. 2011: bar028. PMID 21930503 DOI: 10.1093/database/bar028  0.36
2011 Migliorini D, Bogaerts S, Defever D, Vyas R, Denecker G, Radaelli E, Zwolinska A, Depaepe V, Hochepied T, Skarnes WC, Marine JC. Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice. The Journal of Clinical Investigation. 121: 1329-43. PMID 21403399 DOI: 10.1172/JCI45784  0.36
2011 Tate PH, Skarnes WC. Bi-allelic gene targeting in mouse embryonic stem cells. Methods (San Diego, Calif.). 53: 331-8. PMID 21288739 DOI: 10.1016/j.ymeth.2010.12.025  0.36
2011 Ringwald M, Iyer V, Mason JC, Stone KR, Tadepally HD, Kadin JA, Bult CJ, Eppig JT, Oakley DJ, Briois S, Stupka E, Maselli V, Smedley D, Liu S, Hansen J, ... ... Skarnes WC, et al. The IKMC web portal: a central point of entry to data and resources from the International Knockout Mouse Consortium. Nucleic Acids Research. 39: D849-55. PMID 20929875 DOI: 10.1093/nar/gkq879  0.36
2010 Singla V, Hunkapiller J, Santos N, Seol AD, Norman AR, Wakenight P, Skarnes WC, Reiter JF. Floxin, a resource for genetically engineering mouse ESCs. Nature Methods. 7: 50-2. PMID 19966808 DOI: 10.1038/nmeth.1406  0.36
2009 Pettitt SJ, Liang Q, Rairdan XY, Moran JL, Prosser HM, Beier DR, Lloyd KC, Bradley A, Skarnes WC. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nature Methods. 6: 493-5. PMID 19525957 DOI: 10.1038/nmeth.1342  0.36
2008 Gao X, Tate P, Hu P, Tjian R, Skarnes WC, Wang Z. ES cell pluripotency and germ-layer formation require the SWI/SNF chromatin remodeling component BAF250a. Proceedings of the National Academy of Sciences of the United States of America. 105: 6656-61. PMID 18448678 DOI: 10.1073/pnas.0801802105  0.36
2007 Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y, Bacchetti P, Ferrin TE, Babbitt PC, Doniger SW, Skarnes WC, Young SG, Conklin BR. Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells. Plos One. 2: e617. PMID 17637833 DOI: 10.1371/journal.pone.0000617  0.36
2006 Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, et al. The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Research. 34: D642-8. PMID 16381950 DOI: 10.1093/nar/gkj097  0.36
2006 Reiter JF, Skarnes WC. Tectonic, a novel regulator of the Hedgehog pathway required for both activation and inhibition. Genes & Development. 20: 22-7. PMID 16357211 DOI: 10.1101/gad.1363606  0.36
2005 Parris JJ, Cooke VG, Skarnes WC, Duncan MK, Naik UP. JAM-A expression during embryonic development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 233: 1517-24. PMID 15977176 DOI: 10.1002/dvdy.20481  0.36
2005 Baumeister P, Luo S, Skarnes WC, Sui G, Seto E, Shi Y, Lee AS. Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers. Molecular and Cellular Biology. 25: 4529-40. PMID 15899857 DOI: 10.1128/MCB.25.11.4529-4540.2005  0.36
2004 Wang Z, Zhai W, Richardson JA, Olson EN, Meneses JJ, Firpo MT, Kang C, Skarnes WC, Tjian R. Polybromo protein BAF180 functions in mammalian cardiac chamber maturation. Genes & Development. 18: 3106-16. PMID 15601824 DOI: 10.1101/gad.1238104  0.36
2004 Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, ... ... Skarnes WC, et al. The knockout mouse project. Nature Genetics. 36: 921-4. PMID 15340423 DOI: 10.1038/ng0904-921  0.36
2004 Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J. A public gene trap resource for mouse functional genomics. Nature Genetics. 36: 543-4. PMID 15167922 DOI: 10.1038/ng0604-543  0.36
2003 Yin Y, Kikkawa Y, Mudd JL, Skarnes WC, Sanes JR, Miner JH. Expression of laminin chains by central neurons: analysis with gene and protein trapping techniques. Genesis (New York, N.Y. : 2000). 36: 114-27. PMID 12820173 DOI: 10.1002/gene.10206  0.36
2003 Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Research. 31: 278-81. PMID 12520002 DOI: 10.1093/nar/gkg064  0.36
2002 Bergo MO, Gavino BJ, Steenbergen R, Sturbois B, Parlow AF, Sanan DA, Skarnes WC, Vance JE, Young SG. Defining the importance of phosphatidylserine synthase 2 in mice. The Journal of Biological Chemistry. 277: 47701-8. PMID 12361952 DOI: 10.1074/jbc.M207734200  0.36
2002 Schymeinsky J, Nedbal S, Miosge N, Pöschl E, Rao C, Beier DR, Skarnes WC, Timpl R, Bader BL. Gene structure and functional analysis of the mouse nidogen-2 gene: nidogen-2 is not essential for basement membrane formation in mice. Molecular and Cellular Biology. 22: 6820-30. PMID 12215539 DOI: 10.1128/MCB.22.19.6820-6830.2002  0.36
2001 Zupicich J, Brenner SE, Skarnes WC. Computational prediction of membrane-tethered transcription factors. Genome Biology. 2: RESEARCH0050. PMID 11790253 DOI: 10.1186/gb-2001-2-12-research0050  0.36
2001 Mitchell KJ, Pinson KI, Kelly OG, Brennan J, Zupicich J, Scherz P, Leighton PA, Goodrich LV, Lu X, Avery BJ, Tate P, Dill K, Pangilinan E, Wakenight P, Tessier-Lavigne M, ... Skarnes WC, et al. Functional analysis of secreted and transmembrane proteins critical to mouse development. Nature Genetics. 28: 241-9. PMID 11431694 DOI: 10.1038/90074  0.36
2001 Leighton PA, Mitchell KJ, Goodrich LV, Lu X, Pinson K, Scherz P, Skarnes WC, Tessier-Lavigne M. Defining brain wiring patterns and mechanisms through gene trapping in mice. Nature. 410: 174-9. PMID 11242070 DOI: 10.1038/35065539  0.36
2001 Nadeau JH, Balling R, Barsh G, Beier D, Brown SD, Bucan M, Camper S, Carlson G, Copeland N, Eppig J, Fletcher C, Frankel WN, Ganten D, Goldowitz D, Goodnow C, ... ... Skarnes WC, et al. Sequence interpretation. Functional annotation of mouse genome sequences. Science (New York, N.Y.). 291: 1251-5. PMID 11233449 DOI: 10.1126/science.1058244  0.36
2001 Dionne MS, Skarnes WC, Harland RM. Mutation and analysis of Dan, the founding member of the Dan family of transforming growth factor beta antagonists. Molecular and Cellular Biology. 21: 636-43. PMID 11134349 DOI: 10.1128/MCB.21.2.636-643.2001  0.36
2000 Burgess RW, Skarnes WC, Sanes JR. Agrin isoforms with distinct amino termini: differential expression, localization, and function. The Journal of Cell Biology. 151: 41-52. PMID 11018052 DOI: 10.1083/jcb.151.1.41  0.36
2000 Chen H, Bagri A, Zupicich JA, Zou Y, Stoeckli E, Pleasure SJ, Lowenstein DH, Skarnes WC, Chédotal A, Tessier-Lavigne M. Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. Neuron. 25: 43-56. PMID 10707971 DOI: 10.1016/S0896-6273(00)80870-3  0.36
1999 Wallace MJ, Batt J, Fladd CA, Henderson JT, Skarnes W, Rotin D. Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPσ Nature Genetics. 21: 334-338. PMID 10080192 DOI: 10.1038/6866  0.36
1998 Steel M, Moss J, Clark KA, Kearns IR, Davies CH, Morris RG, Skarnes WC, Lathe R. Gene-trapping to identify and analyze genes expressed in the mouse hippocampus. Hippocampus. 8: 444-57. PMID 9825957 DOI: 10.1002/(SICI)1098-1063(1998)8:5<444::AID-HIPO5>3.0.CO;2-X  0.36
1996 Serafini T, Colamarino SA, Leonardo ED, Wang H, Beddington R, Skarnes WC, Tessier-Lavigne M. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell. 87: 1001-14. PMID 8978605 DOI: 10.1016/S0092-8674(00)81795-X  0.36
1996 Tate P, Skarnes W, Bird A. The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse Nature Genetics. 12: 205-208. PMID 8563762 DOI: 10.1038/ng0296-205  0.36
1995 Skarnes WC, Moss JE, Hurtley SM, Beddington RSP. Capturing genes encoding membrane and secreted proteins important for mouse development Proceedings of the National Academy of Sciences of the United States of America. 92: 6592-6596. PMID 7604039 DOI: 10.1073/pnas.92.14.6592  0.36
1989 Cho KO, Skarnes WC, Minsk B, Palmieri S, Jackson-Grusby L, Wagner JA. Nerve growth factor regulates gene expression by several distinct mechanisms. Molecular and Cellular Biology. 9: 135-43. PMID 2538715  0.36
Low-probability matches
2019 Skarnes WC, Pellegrino E, McDonough JA. Improving homology-directed repair efficiency in human stem cells. Methods (San Diego, Calif.). PMID 31216442 DOI: 10.1016/j.ymeth.2019.06.016  0.2
2004 Kelly OG, Pinson KI, Skarnes WC. The Wnt co-receptors Lrp5 and Lrp6 are essential for gastrulation in mice. Development (Cambridge, England). 131: 2803-15. PMID 15142971 DOI: 10.1242/dev.01137  0.04
2020 Eaton M, Zhang J, Ma Z, Park AC, Lietzke E, Romero CM, Liu Y, Coleman ER, Chen X, Xiao T, Que Z, Lai S, Wu J, Lee JH, Palant S, ... ... Skarnes WC, et al. Generation and basic characterization of a gene-trap knockout mouse model of Scn2a with a substantial reduction of voltage-gated sodium channel Na 1.2 expression. Genes, Brain, and Behavior. e12725. PMID 33369088 DOI: 10.1111/gbb.12725  0.01
2020 Tripathi J, Segeritz CP, Griffiths G, Bushell W, Vallier L, Skarnes WC, Mota MM, Billker O. A Novel Chemically Differentiated Mouse Embryonic Stem Cell-Based Model to Study Liver Stages of Plasmodium berghei. Stem Cell Reports. PMID 32442532 DOI: 10.1016/j.stemcr.2020.04.010  0.01
2020 Mukhopadhyay S, Heinz E, Porreca I, Alasoo K, Yeung A, Yang HT, Schwerd T, Forbester JL, Hale C, Agu CA, Choi YH, Rodrigues J, Capitani M, Jostins-Dean L, Thomas DC, ... ... Skarnes WC, et al. Loss of IL-10 signaling in macrophages limits bacterial killing driven by prostaglandin E2. The Journal of Experimental Medicine. 217. PMID 31819956 DOI: 10.1084/jem.20180649  0.01
2018 Nutter LMJ, Heaney JD, Lloyd KCK, Murray SA, Seavitt JR, Skarnes WC, Teboul L, Brown SDM, Moore M. Response to "Unexpected mutations after CRISPR-Cas9 editing in vivo". Nature Methods. PMID 29600991 DOI: 10.1038/nmeth.4559  0.01
2018 Kaye L, Sun L, Kumar P, Bolisetty M, McDonough J, Skarnes W, Nulsen J, Robson P. Functional investigation of the human primitive syncytium at the maternal-blastocyst interface Fertility and Sterility. 110: e380. DOI: 10.1016/J.FERTNSTERT.2018.07.1063  0.01
2017 Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, ... ... Skarnes WC, et al. Corrigendum: High-throughput discovery of novel developmental phenotypes. Nature. 551: 398. PMID 29144450 DOI: 10.1038/nature24643  0.01
2017 Bowl MR, Simon MM, Ingham NJ, Greenaway S, Santos L, Cater H, Taylor S, Mason J, Kurbatova N, Pearson S, Bower LR, Clary DA, Meziane H, Reilly P, Minowa O, ... ... Skarnes WC, et al. A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction. Nature Communications. 8: 886. PMID 29026089 DOI: 10.1038/s41467-017-00595-4  0.01
2017 Fisher CL, Marks H, Cho LT, Andrews R, Wormald S, Carroll T, Iyer V, Tate P, Rosen B, Stunnenberg HG, Fisher AG, Skarnes WC. An efficient method for generation of bi-allelic null mutant mouse embryonic stem cells and its application for investigating epigenetic modifiers. Nucleic Acids Research. PMID 28981838 DOI: 10.1093/nar/gkx811  0.01
2017 Pardo M, Yu L, Shen S, Tate P, Bode D, Letney BL, Quelle DE, Skarnes W, Choudhary JS. Myst2/Kat7 histone acetyltransferase interaction proteomics reveals tumour-suppressor Niam as a novel binding partner in embryonic stem cells. Scientific Reports. 7: 8157. PMID 28811661 DOI: 10.1038/s41598-017-08456-2  0.01
2017 Meehan TF, Conte N, West DB, Jacobsen JO, Mason J, Warren J, Chen CK, Tudose I, Relac M, Matthews P, Karp N, Santos L, Fiegel T, Ring N, Westerberg H, ... ... Skarnes WC, et al. Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium. Nature Genetics. PMID 28650483 DOI: 10.1038/ng.3901  0.01
2017 Metzakopian E, Strong A, Iyer V, Hodgkins A, Tzelepis K, Antunes L, Friedrich MJ, Kang Q, Davidson T, Lamberth J, Hoffmann C, Davis GD, Vassiliou GS, Skarnes WC, Bradley A. Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries. Scientific Reports. 7: 2244. PMID 28533524 DOI: 10.1038/s41598-017-01766-5  0.01
2017 Yeung ATY, Hale C, Lee AH, Gill EE, Bushell W, Parry-Smith D, Goulding D, Pickard D, Roumeliotis T, Choudhary J, Thomson N, Skarnes WC, Dougan G, Hancock REW. Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis. Nature Communications. 8: 15013. PMID 28440293 DOI: 10.1038/ncomms15013  0.01
2017 Andersson-Rolf A, Mustata RC, Merenda A, Kim J, Perera S, Grego T, Andrews K, Tremble K, Silva JC, Fink J, Skarnes WC, Koo BK. One-step generation of conditional and reversible gene knockouts. Nature Methods. PMID 28135257 DOI: 10.1038/nmeth.4156  0.01
2017 Bressan RB, Dewari PS, Kalantzaki M, Gangoso E, Matjusaitis M, Garcia-Diaz C, Blin C, Grant V, Bulstrode H, Gogolok S, Skarnes WC, Pollard SM. Efficient CRISPR/Cas9-assisted gene targeting enables rapid and precise genetic manipulation of mammalian neural stem cells. Development (Cambridge, England). PMID 28096221 DOI: 10.1242/dev.140855  0.01
2016 Schick JA, Seisenberger C, Beig J, Bürger A, Iyer V, Maier V, Perera S, Rosen B, Skarnes WC, Wurst W. CRISPR-Cas9 enables conditional mutagenesis of challenging loci. Scientific Reports. 6: 32326. PMID 27580957 DOI: 10.1038/srep32326  0.01
2016 Kaloff C, Anastassiadis K, Ayadi A, Baldock R, Beig J, Birling M, Bradley A, Brown S, Bürger A, Bushell W, Chiani F, Collins F, Doe B, Eppig J, Finnell R, ... ... Skarnes W, et al. Genome wide conditional mouse knockout resources Drug Discovery Today: Disease Models. 20: 3-12. DOI: 10.1016/J.DDMOD.2017.08.002  0.01
2015 Takahashi N, Gray D, Strogantsev R, Noon A, Delahaye C, Skarnes WC, Tate PH, Ferguson-Smith AC. ZFP57 and the Targeted Maintenance of Postfertilization Genomic Imprints. Cold Spring Harbor Symposia On Quantitative Biology. 80: 177-87. PMID 27325708 DOI: 10.1101/sqb.2015.80.027466  0.01
2015 Skarnes WC. Is mouse embryonic stem cell technology obsolete? Genome Biology. 16: 109. PMID 26013980 DOI: 10.1186/s13059-015-0673-6  0.01
2012 Skarnes WC. Building and sharing resources. Interview by Krystie Nybo. Biotechniques. 52: 299. PMID 22578120 DOI: 10.2144/000113846  0.01
2011 Guberman JM, Ai J, Arnaiz O, Baran J, Blake A, Baldock R, Chelala C, Croft D, Cros A, Cutts RJ, Di Génova A, Forbes S, Fujisawa T, Gadaleta E, Goodstein DM, et al. BioMart Central Portal: an open database network for the biological community. Database : the Journal of Biological Databases and Curation. 2011: bar041. PMID 21930507 DOI: 10.1093/database/bar041  0.01
2011 Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, et al. A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 474: 337-42. PMID 21677750 DOI: 10.1038/nature10163  0.01
2010 Osterwalder M, Galli A, Rosen B, Skarnes WC, Zeller R, Lopez-Rios J. Dual RMCE for efficient re-engineering of mouse mutant alleles. Nature Methods. 7: 893-5. PMID 20953177 DOI: 10.1038/nmeth.1521  0.01
2010 Fu J, Teucher M, Anastassiadis K, Skarnes W, Stewart AF. A recombineering pipeline to make conditional targeting constructs. Methods in Enzymology. 477: 125-44. PMID 20699140 DOI: 10.1016/S0076-6879(10)77008-7  0.01
2010 Landeira D, Sauer S, Poot R, Dvorkina M, Mazzarella L, Jørgensen HF, Pereira CF, Leleu M, Piccolo FM, Spivakov M, Brookes E, Pombo A, Fisher C, Skarnes WC, Snoek T, et al. Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators. Nature Cell Biology. 12: 618-24. PMID 20473294 DOI: 10.1038/ncb2065  0.01
2008 Brennan J, Skarnes WC. Gene trapping in mouse embryonic stem cells. Methods in Molecular Biology (Clifton, N.J.). 461: 133-48. PMID 19030794 DOI: 10.1007/978-1-60327-483-8_9  0.01
2008 Liang Q, Conte N, Skarnes WC, Bradley A. Extensive genomic copy number variation in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 105: 17453-6. PMID 18988746 DOI: 10.1073/pnas.0805638105  0.01
2006 Mendive F, Laurent P, Van Schoore G, Skarnes W, Pochet R, Vassart G. Defective postnatal development of the male reproductive tract in LGR4 knockout mice. Developmental Biology. 290: 421-34. PMID 16406039 DOI: 10.1016/J.YDBIO.2005.11.043  0.01
2006 Campos LS, Decker L, Taylor V, Skarnes W. Notch, epidermal growth factor receptor, and beta1-integrin pathways are coordinated in neural stem cells. The Journal of Biological Chemistry. 281: 5300-9. PMID 16332675 DOI: 10.1074/jbc.M511886200  0.01
2005 Skarnes WC. Two ways to trap a gene in mice. Proceedings of the National Academy of Sciences of the United States of America. 102: 13001-2. PMID 16150712 DOI: 10.1073/pnas.0506279102  0.01
2005 Henion TR, Raitcheva D, Grosholz R, Biellmann F, Skarnes WC, Hennet T, Schwarting GA. Beta1,3-N-acetylglucosaminyltransferase 1 glycosylation is required for axon pathfinding by olfactory sensory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1894-903. PMID 15728829 DOI: 10.1523/JNEUROSCI.4654-04.2005  0.01
2005 Ren J, Shi M, Liu R, Yang QH, Johnson T, Skarnes WC, Du C. The Birc6 (Bruce) gene regulates p53 and the mitochondrial pathway of apoptosis and is essential for mouse embryonic development. Proceedings of the National Academy of Sciences of the United States of America. 102: 565-70. PMID 15640352 DOI: 10.1073/pnas.0408744102  0.01
2004 Yamada S, Busse M, Ueno M, Kelly OG, Skarnes WC, Sugahara K, Kusche-Gullberg M. Embryonic fibroblasts with a gene trap mutation in Ext1 produce short heparan sulfate chains. The Journal of Biological Chemistry. 279: 32134-41. PMID 15161920 DOI: 10.1074/jbc.M312624200  0.01
2004 Beigneux AP, Kosinski C, Gavino B, Horton JD, Skarnes WC, Young SG. ATP-citrate lyase deficiency in the mouse. The Journal of Biological Chemistry. 279: 9557-64. PMID 14662765 DOI: 10.1074/jbc.M310512200  0.01
2004 Cooke VG, Naik MU, Skarnes W, Naik UP. Junctional Adhesion Molecule-1 Is Involved in bFGF-Induced Angiogenesis In Vivo. Blood. 104: 840-840. DOI: 10.1182/blood.v104.11.840.840  0.01
2002 Gurtu VE, Verma S, Grossmann AH, Liskay RM, Skarnes WC, Baker SM. Maternal effect for DNA mismatch repair in the mouse. Genetics. 160: 271-7. PMID 11805062  0.01
2001 Skarnes WC. Gene trapping methods for the identification and functional analysis of cell surface proteins in mice. Methods in Enzymology. 328: 592-615. PMID 11075368 DOI: 10.1016/S0076-6879(00)28420-6  0.01
2000 Pinson KI, Brennan J, Monkley S, Avery BJ, Skarnes WC. An LDL-receptor-related protein mediates Wnt signalling in mice. Nature. 407: 535-8. PMID 11029008 DOI: 10.1038/35035124  0.01
2000 Paine-Saunders S, Viviano BL, Zupicich J, Skarnes WC, Saunders S. glypican-3 controls cellular responses to Bmp4 in limb patterning and skeletal development. Developmental Biology. 225: 179-87. PMID 10964473 DOI: 10.1006/DBIO.2000.9831  0.01
1997 Townley DJ, Avery BJ, Rosen B, Skarnes WC. Rapid sequence analysis of gene trap integrations to generate a resource of insertional mutations in mice. Genome Research. 7: 293-8. PMID 9074932 DOI: 10.1101/GR.7.3.293  0.01
1994 Skarnes WC. The identification of new genes: gene trapping in transgenic mice. Current Opinion in Biotechnology. 4: 684-9. PMID 7764465 DOI: 10.1016/0958-1669(93)90050-7  0.01
1992 Skarnes WC, Auerbach BA, Joyner AL. A gene trap approach in mouse embryonic stem cells: the lacZ reported is activated by splicing, reflects endogenous gene expression, and is mutagenic in mice. Genes & Development. 6: 903-18. PMID 1592261  0.01
1992 Joyner AL, Auerbach A, Skarnes WC. The gene trap approach in embryonic stem cells: the potential for genetic screens in mice. Ciba Foundation Symposium. 165: 277-88; discussion 2. PMID 1516474  0.01
1991 Skarnes WC, Acheson NH. RNA polymerase II pauses in vitro, but does not terminate, at discrete sites in promoter-proximal regions on polyomavirus transcription complexes. Virology. 182: 54-60. PMID 1850913 DOI: 10.1016/0042-6822(91)90647-T  0.01
1991 Skarnes WC. Entrapment vectors: a new tool for mammalian genetics. Bio/Technology (Nature Publishing Company). 8: 827-31. PMID 1366793 DOI: 10.1038/NBT0990-827  0.01
1989 Joyner AL, Skarnes WC, Rossant J. Production of a mutation in mouse En-2 gene by homologous recombination in embryonic stem cells. Nature. 338: 153-6. PMID 2563902 DOI: 10.1038/338153a0  0.01
1989 Gossler A, Joyner AL, Rossant J, Skarnes WC. Mouse embryonic stem cells and reporter constructs to detect developmentally regulated genes. Science (New York, N.Y.). 244: 463-5. PMID 2497519  0.01
1988 Skarnes WC, Tessier DC, Acheson NH. RNA polymerases stall and/or prematurely terminate nearby both early and late promoters on polyomavirus DNA. Journal of Molecular Biology. 203: 153-71. PMID 2846852 DOI: 10.1016/0022-2836(88)90099-X  0.01
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