Stanley J. Korsmeyer - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
 2005 Dana-Farber Cancer Institute, Boston, MA, United States 
Area:
Cell Biology, Molecular Biology

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Zamorano S, Rojas-Rivera D, Lisbona F, Parra V, Court FA, Villegas R, Cheng EH, Korsmeyer SJ, Lavandero S, Hetz C. A BAX/BAK and cyclophilin D-independent intrinsic apoptosis pathway. Plos One. 7: e37782. PMID 22719850 DOI: 10.1371/journal.pone.0037782  0.88
2012 He C, Bassik MC, Moresi V, Sun K, Wei Y, Zou Z, An Z, Loh J, Fisher J, Sun Q, Korsmeyer S, Packer M, May HI, Hill JA, Virgin HW, et al. Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis. Nature. 481: 511-5. PMID 22258505 DOI: 10.1038/nature10758  0.88
2012 Chen DY, Lee Y, Van Tine BA, Searleman AC, Westergard TD, Liu H, Tu HC, Takeda S, Dong Y, Piwnica-Worms DR, Oh KJ, Korsmeyer SJ, Hermone A, Gussio R, Shoemaker RH, et al. A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer Research. 72: 736-46. PMID 22166309 DOI: 10.1158/0008-5472.CAN-11-2584  0.88
2010 Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, et al. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science (New York, N.Y.). 327: 593-6. PMID 20019247 DOI: 10.1126/science.1166202  0.88
2009 Ren D, Kim H, Tu HC, Westergard TD, Fisher JK, Rubens JA, Korsmeyer SJ, Hsieh JJ, Cheng EH. The VDAC2-BAK rheostat controls thymocyte survival. Science Signaling. 2: ra48. PMID 19706873 DOI: 10.1126/scisignal.2000274  0.4
2008 Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, ... ... Korsmeyer SJ, et al. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nature Medicine. 14: 144-53. PMID 18223655 DOI: 10.1038/nm1717  0.88
2008 Woodland RT, Fox CJ, Schmidt MR, Hammerman PS, Opferman JT, Korsmeyer SJ, Hilbert DM, Thompson CB. Multiple signaling pathways promote B lymphocyte stimulator dependent B-cell growth and survival. Blood. 111: 750-60. PMID 17942753 DOI: 10.1182/blood-2007-03-077222  0.88
2007 Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, et al. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nature Medicine. 13: 992-7. PMID 17676052 DOI: 10.1038/nm1602  0.88
2007 Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL. Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. Journal of the American Chemical Society. 129: 2456-7. PMID 17284038 DOI: 10.1021/ja0693587  0.88
2006 Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ. A stapled BID BH3 helix directly binds and activates BAX. Molecular Cell. 24: 199-210. PMID 17052454 DOI: 10.1016/j.molcel.2006.08.020  0.88
2006 Oh KJ, Barbuto S, Pitter K, Morash J, Walensky LD, Korsmeyer SJ. A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro. The Journal of Biological Chemistry. 281: 36999-7008. PMID 16987815 DOI: 10.1074/jbc.M602341200  0.88
2006 Takeda S, Chen DY, Westergard TD, Fisher JK, Rubens JA, Sasagawa S, Kan JT, Korsmeyer SJ, Cheng EH, Hsieh JJ. Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression. Genes & Development. 20: 2397-409. PMID 16951254 DOI: 10.1101/gad.1449406  0.4
2006 Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, Roberts TM. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum Journal of Biological Chemistry. 281: 23003-23012. PMID 16717086 DOI: 10.1074/jbc.M602648200  0.88
2006 Hetz C, Bernasconi P, Fisher J, Lee AH, Bassik MC, Antonsson B, Brandt GS, Iwakoshi NN, Schrinzel A, Glimcher LH, Korsmeyer SJ. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1α Science. 312: 572-576. PMID 16645094 DOI: 10.1126/science.1123480  0.88
2006 Goldsmith KC, Liu X, Dam V, Morgan BT, Shabbout M, Cnaan A, Letai A, Korsmeyer SJ, Hogarty MD. BH3 peptidomimetics potently activate apoptosis and demonstrate single agent efficacy in neuroblastoma Oncogene. 25: 4525-4533. PMID 16568093 DOI: 10.1038/sj.onc.1209489  0.88
2006 Zhou H, Spicuglia S, Hsieh JJ, Mitsiou DJ, Høiby T, Veenstra GJ, Korsmeyer SJ, Stunnenberg HG. Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. Molecular and Cellular Biology. 26: 2728-35. PMID 16537915 DOI: 10.1128/MCB.26.7.2728-2735.2006  0.4
2005 Zinkel SS, Hurov KE, Ong C, Abtahi FM, Gross A, Korsmeyer SJ. A role for proapoptotic BID in the DNA-damage response. Cell. 122: 579-91. PMID 16122425 DOI: 10.1016/j.cell.2005.06.022  0.48
2005 Schinzel AC, Takeuchi O, Huang Z, Fisher JK, Zhou Z, Rubens J, Hetz C, Danial NN, Moskowitz MA, Korsmeyer SJ. Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proceedings of the National Academy of Sciences of the United States of America. 102: 12005-10. PMID 16103352 DOI: 10.1073/pnas.0505294102  0.32
2005 Takeuchi O, Fisher J, Suh H, Harada H, Malynn BA, Korsmeyer SJ. Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 11272-7. PMID 16055554 DOI: 10.1073/pnas.0504783102  0.4
2005 Oltersdorf T, Elmore SW, Shoemaker AR, Armstrong RC, Augeri DJ, Belli BA, Bruncko M, Deckwerth TL, Dinges J, Hajduk PJ, Joseph MK, Kitada S, Korsmeyer SJ, Kunzer AR, Letai A, et al. An inhibitor of Bcl-2 family proteins induces regression of solid tumours. Nature. 435: 677-81. PMID 15902208 DOI: 10.1038/nature03579  0.88
2005 Mandal M, Borowski C, Palomero T, Ferrando AA, Oberdoerffer P, Meng F, Ruiz-Vela A, Ciofani M, Zuniga-Pflucker JC, Screpanti I, Look AT, Korsmeyer SJ, Rajewsky K, Von Boehmer H, Aifantis I. The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival Journal of Experimental Medicine. 201: 603-614. PMID 15728238 DOI: 10.1084/jem.20041924  0.88
2005 Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P, Anastasiadou E, Kutok JL, Kogan SC, Zinkel SS, Fisher JK, Hess JL, Golub TR, Armstrong SA, Akashi K, ... Korsmeyer SJ, et al. Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. The Embo Journal. 24: 368-81. PMID 15635450 DOI: 10.1038/sj.emboj.7600521  0.88
2005 Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ. Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proceedings of the National Academy of Sciences of the United States of America. 102: 105-10. PMID 15613488 DOI: 10.1073/pnas.0408352102  0.88
2005 Oh KJ, Barbuto S, Meyer N, Kim RS, Collier RJ, Korsmeyer SJ. Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding. A site-directed spin labeling study. The Journal of Biological Chemistry. 280: 753-67. PMID 15501827 DOI: 10.1074/jbc.M405428200  0.88
2004 Ernst P, Mabon M, Davidson AJ, Zon LI, Korsmeyer SJ. An Mll-dependent Hox program drives hematopoietic progenitor expansion. Current Biology : Cb. 14: 2063-9. PMID 15556871 DOI: 10.1016/j.cub.2004.11.012  0.68
2004 Harada H, Quearry B, Ruiz-Vela A, Korsmeyer SJ. Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity. Proceedings of the National Academy of Sciences of the United States of America. 101: 15313-7. PMID 15486085 DOI: 10.1073/pnas.0406837101  0.4
2004 Oakes SA, Korsmeyer SJ. Untangling the web: mitochondrial fission and apoptosis. Developmental Cell. 7: 460-2. PMID 15469833 DOI: 10.1016/j.devcel.2004.09.010  0.88
2004 Nam YJ, Mani K, Ashton AW, Peng CF, Krishnamurthy B, Hayakawa Y, Lee P, Korsmeyer SJ, Kitsis RN. Inhibition of both the extrinsic and intrinsic death pathways through nonhomotypic death-fold interactions. Molecular Cell. 15: 901-12. PMID 15383280 DOI: 10.1016/j.molcel.2004.08.020  0.88
2004 Letai A, Sorcinelli MD, Beard C, Korsmeyer SJ. Antiapoptotic BCL-2 is required for maintenance of a model leukemia Cancer Cell. 6: 241-249. PMID 15380515 DOI: 10.1016/j.ccr.2004.07.011  0.88
2004 Jamerson MH, Johnson MD, Korsmeyer SJ, Furth PA, Dickson RB. Bax regulates c-Myc-induced mammary tumour apoptosis but not proliferation in MMTV-c-myc transgenic mice. British Journal of Cancer. 91: 1372-9. PMID 15354213 DOI: 10.1038/sj.bjc.6602137  0.88
2004 Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ. Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science (New York, N.Y.). 305: 1466-70. PMID 15353804 DOI: 10.1126/science.1099191  0.88
2004 Mori M, Burgess DL, Gefrides LA, Foreman PJ, Opferman JT, Korsmeyer SJ, Cavalheiro EA, Naffah-Mazzacoratti MG, Noebels JL. Expression of apoptosis inhibitor protein Mcl1 linked to neuroprotection in CNS neurons. Cell Death and Differentiation. 11: 1223-33. PMID 15286683 DOI: 10.1038/sj.cdd.4401483  0.88
2004 Seo SY, Chen YB, Ivanovska I, Ranger AM, Hong SJ, Dawson VL, Korsmeyer SJ, Bellows DS, Fannjiang Y, Hardwick JM. BAD is a pro-survival factor prior to activation of its pro-apoptotic function. The Journal of Biological Chemistry. 279: 42240-9. PMID 15231831 DOI: 10.1074/jbc.M406775200  0.88
2004 Guo L, Pietkiewicz D, Pavlov EV, Grigoriev SM, Kasianowicz JJ, Dejean LM, Korsmeyer SJ, Antonsson B, Kinnally KW. Effects of cytochrome c on the mitochondrial apoptosis-induced channel MAC. American Journal of Physiology. Cell Physiology. 286: C1109-17. PMID 15075210 DOI: 10.1152/ajpcell.00183.2003  0.88
2004 Ernst P, Fisher JK, Avery W, Wade S, Foy D, Korsmeyer SJ. Definitive hematopoiesis requires the mixed-lineage leukemia gene. Developmental Cell. 6: 437-43. PMID 15030765  0.68
2004 Bassik MC, Scorrano L, Oakes SA, Pozzan T, Korsmeyer SJ. Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. The Embo Journal. 23: 1207-16. PMID 15010700 DOI: 10.1038/sj.emboj.7600104  0.88
2004 Armstrong SA, Mabon ME, Silverman LB, Li A, Gribben JG, Fox EA, Sallan SE, Korsmeyer SJ. FLT3 mutations in childhood acute lymphoblastic leukemia. Blood. 103: 3544-6. PMID 14670924 DOI: 10.1182/blood-2003-07-2441  0.88
2003 Chavez-Reyes A, Parant JM, Amelse LL, de Oca Luna RM, Korsmeyer SJ, Lozano G. Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Research. 63: 8664-9. PMID 14695178  0.88
2003 Opferman JT, Letai A, Beard C, Sorcinelli MD, Ong CC, Korsmeyer SJ. Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1. Nature. 426: 671-6. PMID 14668867 DOI: 10.1038/nature02067  0.88
2003 Hsieh JJ, Cheng EH, Korsmeyer SJ. Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell. 115: 293-303. PMID 14636557  0.4
2003 D'Sa C, Klocke BJ, Cecconi F, Lindsten T, Thompson CB, Korsmeyer SJ, Flavell RA, Roth KA. Caspase regulation of genotoxin-induced neural precursor cell death. Journal of Neuroscience Research. 74: 435-45. PMID 14598320 DOI: 10.1002/jnr.10738  0.88
2003 Armstrong SA, Golub TR, Korsmeyer SJ. MLL-rearranged leukemias: insights from gene expression profiling. Seminars in Hematology. 40: 268-73. PMID 14582077 DOI: 10.1016/S0037-1963(03)00196-3  0.88
2003 Oakes SA, Opferman JT, Pozzan T, Korsmeyer SJ, Scorrano L. Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochemical Pharmacology. 66: 1335-40. PMID 14555206 DOI: 10.1016/S0006-2952(03)00482-9  0.88
2003 Davidson AJ, Ernst P, Wang Y, Dekens MP, Kingsley PD, Palis J, Korsmeyer SJ, Daley GQ, Zon LI. cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes. Nature. 425: 300-6. PMID 13679919 DOI: 10.1038/nature01973  0.68
2003 Armstrong SA, Korsmeyer SJ. Comparison of human genomics and genetic models of cancer to identify novel therapeutic targets Cell Cycle (Georgetown, Tex.). 2: 408-409. PMID 12963826  0.88
2003 Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature. 424: 952-6. PMID 12931191 DOI: 10.1038/nature01825  0.88
2003 Cheng EH, Sheiko TV, Fisher JK, Craigen WJ, Korsmeyer SJ. VDAC2 inhibits BAK activation and mitochondrial apoptosis. Science (New York, N.Y.). 301: 513-7. PMID 12881569 DOI: 10.1126/science.1083995  0.32
2003 Ranger AM, Zha J, Harada H, Datta SR, Danial NN, Gilmore AP, Kutok JL, Le Beau MM, Greenberg ME, Korsmeyer SJ. Bad-deficient mice develop diffuse large B cell lymphoma. Proceedings of the National Academy of Sciences of the United States of America. 100: 9324-9. PMID 12876200 DOI: 10.1073/pnas.1533446100  0.88
2003 Kandasamy K, Srinivasula SM, Alnemri ES, Thompson CB, Korsmeyer SJ, Bryant JL, Srivastava RK. Involvement of proapoptotic molecules Bax and Bak in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced mitochondrial disruption and apoptosis: differential regulation of cytochrome c and Smac/DIABLO release. Cancer Research. 63: 1712-21. PMID 12670926  0.88
2003 Ferrando AA, Armstrong SA, Neuberg DS, Sallan SE, Silverman LB, Korsmeyer SJ, Look AT. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood. 102: 262-8. PMID 12637319 DOI: 10.1182/blood-2002-10-3221  0.88
2003 Scorrano L, Oakes SA, Opferman JT, Cheng EH, Sorcinelli MD, Pozzan T, Korsmeyer SJ. BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science (New York, N.Y.). 300: 135-9. PMID 12624178 DOI: 10.1126/science.1081208  0.88
2003 Armstrong SA, Kung AL, Mabon ME, Silverman LB, Stam RW, Den Boer ML, Pieters R, Kersey JH, Sallan SE, Fletcher JA, Golub TR, Griffin JD, Korsmeyer SJ. Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell. 3: 173-83. PMID 12620411 DOI: 10.1016/S1535-6108(03)00003-5  0.88
2003 Johnson H, Scorrano L, Korsmeyer SJ, Ley TJ. Cell death induced by granzyme C. Blood. 101: 3093-101. PMID 12515723 DOI: 10.1182/blood-2002-08-2485  0.88
2003 Perfettini JL, Ojcius DM, Andrews CW, Korsmeyer SJ, Rank RG, Darville T. Role of proapoptotic BAX in propagation of Chlamydia muridarum (the mouse pneumonitis strain of Chlamydia trachomatis) and the host inflammatory response Journal of Biological Chemistry. 278: 9496-9502. PMID 12509420 DOI: 10.1074/jbc.M211275200  0.88
2003 Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo Endocrinology. 144: 69-74. PMID 12488331 DOI: 10.1210/en.2002-220814  0.88
2003 Hsieh JJ, Ernst P, Erdjument-Bromage H, Tempst P, Korsmeyer SJ. Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization. Molecular and Cellular Biology. 23: 186-94. PMID 12482972  0.68
2003 Stam RW, Den Boer ML, Meijerink JPP, Ebus MEG, Peters GJ, Noordhuis P, Janka-Schaub GE, Armstrong SA, Korsmeyer SJ, Pieters R. Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia Blood. 101: 1270-1276. PMID 12406912 DOI: 10.1182/blood-2002-05-1600  0.88
2002 Datta SR, Ranger AM, Lin MZ, Sturgill JF, Ma YC, Cowan CW, Dikkes P, Korsmeyer SJ, Greenberg ME. Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis. Developmental Cell. 3: 631-43. PMID 12431371 DOI: 10.1016/S1534-5807(02)00326-X  0.88
2002 Sax JK, Fei P, Murphy ME, Bernhard E, Korsmeyer SJ, El-Deiry WS. BID regulation by p53 contributes to chemosensitivity. Nature Cell Biology. 4: 842-9. PMID 12402042 DOI: 10.1038/ncb866  0.88
2002 Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics Cancer Cell. 2: 183-192. PMID 12242151 DOI: 10.1016/S1535-6108(02)00127-7  0.88
2002 Fantin VR, Berardi MJ, Scorrano L, Korsmeyer SJ, Leder P. A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth. Cancer Cell. 2: 29-42. PMID 12150823 DOI: 10.1016/S1535-6108(02)00082-X  0.88
2002 McGill GG, Horstmann M, Widlund HR, Du J, Motyckova G, Nishimura EK, Lin YL, Ramaswamy S, Avery W, Ding HF, Jordan SA, Jackson IJ, Korsmeyer SJ, Golub TR, Fisher DE. Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell. 109: 707-18. PMID 12086670 DOI: 10.1016/S0092-8674(02)00762-6  0.88
2002 Armstrong SA, Hsieh JJ, Korsmeyer SJ. Genomic approaches to the pathogenesis and treatment of acute lymphoblastic leukemias. Current Opinion in Hematology. 9: 339-44. PMID 12042709 DOI: 10.1097/00062752-200207000-00012  0.88
2002 Ernst P, Wang J, Korsmeyer SJ. The role of MLL in hematopoiesis and leukemia. Current Opinion in Hematology. 9: 282-7. PMID 12042701  0.68
2002 Scorrano L, Ashiya M, Buttle K, Weiler S, Oakes SA, Mannella CA, Korsmeyer SJ. A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Developmental Cell. 2: 55-67. PMID 11782314 DOI: 10.1016/S1534-5807(01)00116-2  0.88
2002 Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD, Sallan SE, Lander ES, Golub TR, Korsmeyer SJ. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nature Genetics. 30: 41-7. PMID 11731795 DOI: 10.1038/ng765  0.88
2001 Thomas DA, Scorrano L, Putcha GV, Korsmeyer SJ, Ley TJ. Granzyme B can cause mitochondrial depolarization and cell death in the absence of BID, BAX, and BAK. Proceedings of the National Academy of Sciences of the United States of America. 98: 14985-90. PMID 11752447 DOI: 10.1073/pnas.261581498  0.88
2001 Plesnila N, Zinkel S, Le DA, Amin-Hanjani S, Wu Y, Qiu J, Chiarugi A, Thomas SS, Kohane DS, Korsmeyer SJ, Moskowitz MA. BID mediates neuronal cell death after oxygen/glucose deprivation and focal cerebral ischemia Proceedings of the National Academy of Sciences of the United States of America. 98: 15318-15323. PMID 11742085 DOI: 10.1073/pnas.261323298  0.88
2001 Zaidi AU, McDonough JS, Klocke BJ, Latham CB, Korsmeyer SJ, Flavell RA, Schmidt RE, Roth KA. Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent. Journal of Neuropathology and Experimental Neurology. 60: 937-45. PMID 11589424 DOI: 10.1093/jnen/60.10.937  0.88
2001 Cheng EH, Wei MC, Weiler S, Flavell RA, Mak TW, Lindsten T, Korsmeyer SJ. BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis. Molecular Cell. 8: 705-11. PMID 11583631 DOI: 10.1016/S1097-2765(01)00320-3  0.48
2001 Leonard JR, D'Sa C, Cahn BR, Korsmeyer SJ, Roth KA. Bid regulation of neuronal apoptosis. Brain Research. Developmental Brain Research. 128: 187-90. PMID 11412905 DOI: 10.1016/S0165-3806(01)00174-2  0.88
2001 Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, Korsmeyer SJ. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science (New York, N.Y.). 292: 727-30. PMID 11326099 DOI: 10.1126/science.1059108  0.48
2001 Ernst P, Wang J, Huang M, Goodman RH, Korsmeyer SJ. MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Molecular and Cellular Biology. 21: 2249-58. PMID 11259575 DOI: 10.1128/MCB.21.7.2249-2258.2001  0.88
2001 Vila M, Jackson-Lewis V, Vukosavic S, Djaldetti R, Liberatore G, Offen D, Korsmeyer SJ, Przedborski S. Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease Proceedings of the National Academy of Sciences of the United States of America. 98: 2837-2842. PMID 11226327 DOI: 10.1073/pnas.051633998  0.88
2001 Mootha VK, Wei MC, Buttle KF, Scorrano L, Panoutsakopoulou V, Mannella CA, Korsmeyer SJ. A reversible component of mitochondrial respiratory dysfunction in apoptosis can be rescued by exogenous cytochrome c. The Embo Journal. 20: 661-71. PMID 11179211 DOI: 10.1093/emboj/20.4.661  0.48
2001 Wen R, Wang D, McKay C, Bunting KD, Marine JC, Vanin EF, Zambetti GP, Korsmeyer SJ, Ihle JN, Cleveland JL. Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development. Molecular and Cellular Biology. 21: 678-89. PMID 11134353 DOI: 10.1128/MCB.21.2.678-689.2001  0.88
2000 Korsmeyer SJ, Wei MC, Saito M, Weiler S, Oh KJ, Schlesinger PH. Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c. Cell Death and Differentiation. 7: 1166-73. PMID 11175253 DOI: 10.1038/sj.cdd.4400783  0.88
2000 Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA, Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, ... ... Korsmeyer SJ, et al. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Molecular Cell. 6: 1389-99. PMID 11163212 DOI: 10.1016/S1097-2765(00)00136-2  0.88
2000 Ruffolo SC, Breckenridge DG, Nguyen M, Goping IS, Gross A, Korsmeyer SJ, Li H, Yuan J, Shore GC. BID-dependent and BID-independent pathways for BAX insertion into mitochondria Cell Death and Differentiation. 7: 1101-1108. PMID 11139284  0.88
2000 Zha J, Weiler S, Oh KJ, Wei MC, Korsmeyer SJ. Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. Science (New York, N.Y.). 290: 1761-5. PMID 11099414 DOI: 10.1126/science.290.5497.1761  0.88
2000 Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB, Korsmeyer SJ. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes & Development. 14: 2060-71. PMID 10950869  0.48
2000 Saito M, Korsmeyer SJ, Schlesinger PH. BAX-dependent transport of cytochrome C reconstituted in pure liposomes Nature Cell Biology. 2: 553-555. PMID 10934477 DOI: 10.1038/35019596  0.88
2000 Doughty ML, De Jager PL, Korsmeyer SJ, Heintz N. Neurodegeneration in Lurcher mice occurs via multiple cell death pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 3687-94. PMID 10804210  0.88
2000 Gross A, Pilcher K, Blachly-Dyson E, Basso E, Jockel J, Bassik MC, Korsmeyer SJ, Forte M. Biochemical and genetic analysis of the mitochondrial response of yeast to BAX and BCL-X(L) Molecular and Cellular Biology. 20: 3125-3136. PMID 10757797 DOI: 10.1128/MCB.20.9.3125-3136.2000  0.88
2000 Shirasawa S, Arata A, Onimaru H, Roth KA, Brown GA, Horning S, Arata S, Okumura K, Sasazuki T, Korsmeyer SJ. Rnx deficiency results in congenital central hypoventilation. Nature Genetics. 24: 287-90. PMID 10700185 DOI: 10.1038/73516  0.88
1999 Hotchkiss RS, Tinsley KW, Swanson PE, Chang KC, Cobb JP, Buchman TG, Korsmeyer SJ, Karl IE. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 14541-6. PMID 10588741 DOI: 10.1073/pnas.96.25.14541  0.88
1999 Hanson RD, Hess JL, Yu BD, Ernst P, van Lohuizen M, Berns A, van der Lugt NM, Shashikant CS, Ruddle FH, Seto M, Korsmeyer SJ. Mammalian Trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proceedings of the National Academy of Sciences of the United States of America. 96: 14372-7. PMID 10588712 DOI: 10.1073/pnas.96.25.14372  0.88
1999 Yin XM, Wang K, Gross A, Zhao Y, Zinkel S, Klocke B, Roth KA, Korsmeyer SJ. Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis. Nature. 400: 886-91. PMID 10476969 DOI: 10.1038/23730  0.88
1999 Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes & Development. 13: 1899-911. PMID 10444588 DOI: 10.1101/GAD.13.15.1899  0.48
1999 Lewis J, Oyler GA, Ueno K, Fannjiang YR, Chau BN, Vornov J, Korsmeyer SJ, Zou S, Hardwick JM. Inhibition of virus-induced neuronal apoptosis by Bax. Nature Medicine. 5: 832-5. PMID 10395331 DOI: 10.1038/10556  0.88
1999 McDonnell JM, Fushman D, Milliman CL, Korsmeyer SJ, Cowburn D. Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists. Cell. 96: 625-34. PMID 10089878  0.88
1999 Bar-Peled O, Knudson M, Korsmeyer SJ, Rothstein JD. Motor neuron degeneration is attenuated in bax-deficient neurons in vitro. Journal of Neuroscience Research. 55: 542-56. PMID 10082077 DOI: 10.1002/(SICI)1097-4547(19990301)55:5<542::AID-JNR2>3.0.CO;2-7  0.88
1999 Lentz SI, Knudson CM, Korsmeyer SJ, Snider WD. Neurotrophins support the development of diverse sensory axon morphologies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 1038-48. PMID 9920667  0.88
1999 Gross A, Yin XM, Wang K, Wei MC, Jockel J, Milliman C, Erdjument-Bromage H, Tempst P, Korsmeyer SJ. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. The Journal of Biological Chemistry. 274: 1156-63. PMID 9873064  0.48
1998 Shindler KS, Yunker AM, Cahn R, Zha J, Korsmeyer SJ, Roth KA. Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro. Cell Death and Differentiation. 5: 901-10. PMID 10203689 DOI: 10.1038/sj.cdd.4400421  0.88
1998 Moley KH, Chi MM, Knudson CM, Korsmeyer SJ, Mueckler MM. Hyperglycemia induces apoptosis in pre-implantation embryos through cell death effector pathways. Nature Medicine. 4: 1421-4. PMID 9846581 DOI: 10.1038/4013  0.88
1998 Wang K, Yin XM, Copeland NG, Gilbert DJ, Jenkins NA, Keck CL, Zimonjic DB, Popescu NC, Korsmeyer SJ. BID, a proapoptotic BCL-2 family member, is localized to mouse chromosome 6 and human chromosome 22q11. Genomics. 53: 235-8. PMID 9790773 DOI: 10.1006/geno.1998.5489  0.32
1998 Wang K, Gross A, Waksman G, Korsmeyer SJ. Mutagenesis of the BH3 domain of BAX identifies residues critical for dimerization and killing Molecular and Cellular Biology. 18: 6083-6089. PMID 9742125  0.88
1998 Deckwerth TL, Easton RM, Knudson CM, Korsmeyer SJ, Johnson EM. Placement of the BCL2 family member BAX in the death pathway of sympathetic neurons activated by trophic factor deprivation. Experimental Neurology. 152: 150-62. PMID 9682022 DOI: 10.1006/exnr.1998.6846  0.88
1998 Gross A, Jockel J, Wei MC, Korsmeyer SJ. Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis. The Embo Journal. 17: 3878-85. PMID 9670005 DOI: 10.1093/emboj/17.14.3878  0.48
1998 White FA, Keller-Peck CR, Knudson CM, Korsmeyer SJ, Snider WD. Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 1428-39. PMID 9454852  0.88
1997 Schlesinger PH, Gross A, Yin XM, Yamamoto K, Saito M, Waksman G, Korsmeyer SJ. Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2 Proceedings of the National Academy of Sciences of the United States of America. 94: 11357-11362. PMID 9326614 DOI: 10.1073/pnas.94.21.11357  0.88
1997 Miller TM, Moulder KL, Knudson CM, Creedon DJ, Deshmukh M, Korsmeyer SJ, Johnson EM. Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. The Journal of Cell Biology. 139: 205-17. PMID 9314540 DOI: 10.1083/jcb.139.1.205  0.88
1997 Zha J, Harada H, Osipov K, Jockel J, Waksman G, Korsmeyer SJ. BH3 domain of BAD is required for heterodimerization with BCL-X(L) and pro-apoptotic activity Journal of Biological Chemistry. 272: 24101-24104. PMID 9305851 DOI: 10.1074/jbc.272.39.24101  0.88
1997 Karrer U, Althage A, Odermatt B, Roberts CW, Korsmeyer SJ, Miyawaki S, Hengartner H, Zinkernagel RM. On the key role of secondary lymphoid organs in antiviral immune responses studied in alymphoplastic (aly/aly) and spleenless (Hox11(-)/-) mutant mice. The Journal of Experimental Medicine. 185: 2157-70. PMID 9182687 DOI: 10.1084/jem.185.12.2157  0.88
1997 Shirasawa S, Yunker AM, Roth KA, Brown GA, Horning S, Korsmeyer SJ. Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon. Nature Medicine. 3: 646-50. PMID 9176491 DOI: 10.1038/nm0697-646  0.88
1997 Merry DE, Korsmeyer SJ. Bcl-2 gene family in the nervous system Annual Review of Neuroscience. 20: 245-257. PMID 9056714 DOI: 10.1146/annurev.neuro.20.1.245  0.88
1996 Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L) Cell. 87: 619-628. PMID 8929531 DOI: 10.1016/S0092-8674(00)81382-3  0.88
1996 Deckwerth TL, Elliott JL, Knudson CM, Johnson EM, Snider WD, Korsmeyer SJ. BAX is required for neuronal death after trophic factor deprivation and during development. Neuron. 17: 401-11. PMID 8816704 DOI: 10.1016/S0896-6273(00)80173-7  0.88
1996 Chen G, Branton PE, Yang E, Korsmeyer SJ, Shore GC. Adenovirus E1B 19-kDa death suppressor protein interacts with Bax but not with Bad Journal of Biological Chemistry. 271: 24221-24225. PMID 8798665 DOI: 10.1074/jbc.271.39.24221  0.88
1996 Armstrong RC, Aja T, Xiang J, Gaur S, Krebs JF, Hoang K, Bai X, Korsmeyer SJ, Karanewsky DS, Fritz LC, Tomaselli KJ. Fas-induced activation of the cell death-related protease CPP32 Is inhibited by Bcl-2 and by ICE family protease inhibitors. The Journal of Biological Chemistry. 271: 16850-5. PMID 8663439 DOI: 10.1074/jbc.271.28.16850  0.88
1994 Tao W, Teh SJ, Melhado I, Jirik F, Korsmeyer SJ, Teh HS. The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus Journal of Experimental Medicine. 179: 145-153. PMID 8270861 DOI: 10.1084/jem.179.1.145  0.88
1994 Griffiths SD, Goodhead DT, Marsden SJ, Wright EG, Krajewski S, Reed JC, Korsmeyer SJ, Greaves M. Interleukin 7-dependent B lymphocyte precursor cells are ultrasensitive to apoptosis. The Journal of Experimental Medicine. 179: 1789-97. PMID 8195708 DOI: 10.1084/jem.179.6.1789  0.88
1994 Ashwell JD, Berger NA, Cidlowski JA, Lane DP, Korsmeyer SJ. Coming to terms with death: apoptosis in cancer and immune development. Immunology Today. 15: 147-51. PMID 7911020 DOI: 10.1016/0167-5699(94)90309-3  0.88
1993 Martin JM, Veis D, Korsmeyer SJ, Sugden B. Latent membrane protein of Epstein-Barr virus induces cellular phenotypes independently of expression of Bcl-2 Journal of Virology. 67: 5269-5278. PMID 8394449  0.88
1993 Young RL, Korsmeyer SJ. A negative regulatory element in the bcl-2 5'-untranslated region inhibits expression from an upstream promoter Molecular and Cellular Biology. 13: 3686-3697. PMID 8388542 DOI: 10.1128/MCB.13.6.3686  0.88
1992 McGuire EA, Rintoul CE, Sclar GM, Korsmeyer SJ. Thymic overexpression of Ttg-1 in transgenic mice results in T-cell acute lymphoblastic leukemia/lymphoma. Molecular and Cellular Biology. 12: 4186-96. PMID 1508213 DOI: 10.1128/MCB.12.9.4186  0.88
1991 Silverman GA, Jockel JI, Domer PH, Mohr RM, Taillon-Miller P, Korsmeyer SJ. Yeast artificial chromosome cloning of a two-megabase-size contig within chromosomal band 18q21 establishes physical linkage between BCL2 and plasminogen activator inhibitor type-2. Genomics. 9: 219-28. PMID 2004771 DOI: 10.1016/0888-7543(91)90245-A  0.88
1991 Yeh Tm, Korsmeyer SJ, Teale JM. Skewed B cell VH family repertoire in Bcl-2- transgenic mice International Immunology. 3: 1329-1333. PMID 1777425 DOI: 10.1093/intimm/3.12.1329  0.88
1990 Zutter M, Hockett RD, Roberts CWM, Mcguire EA, Bloomstone J, Morton CC, Deaven LL, Crist WM, Carroll AJ, Korsmeyer SJ. The t(10;14)(q24;q11) of T-cell acute lymphoblastic leukemia juxtaposes the S T-cell receptor with TCL3, a conserved and activated locus at 10q24 Proceedings of the National Academy of Sciences of the United States of America. 87: 3161-3165. PMID 2326274 DOI: 10.1073/pnas.87.8.3161  0.88
1989 Nunez G, Seto M, Seremetis S, Ferrero D, Grignani F, Korsmeyer SJ, Dalla-Favera R. Growth- and tumor-promoting effects of deregulated BCL2 in human B-lymphoblastoid cells Proceedings of the National Academy of Sciences of the United States of America. 86: 4589-4593. PMID 2543982  0.88
1989 McGuire EA, Hockett RD, Pollock KM, Bartholdi MF, O'Brien SJ, Korsmeyer SJ. The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein Molecular and Cellular Biology. 9: 2124-2132. PMID 2501659 DOI: 10.1128/MCB.9.5.2124  0.88
1988 Hockett RD, De Villartay JP, Pollock K, Poplack DG, Cohen DI, Korsmeyer SJ. Human T-cell antigen receptor (TCR) δ-chain locus and elements responsible for its deletion are within the TCR α-chain locus Proceedings of the National Academy of Sciences of the United States of America. 85: 9694-9698. PMID 2974161 DOI: 10.1073/PNAS.85.24.9694  0.88
1988 De Villartay JP, Hockett RD, Coran D, Korsmeyer SJ, Cohen DI. Deletion of the human T-cell receptor δ-gene by a site-specific recombination Nature. 335: 170-174. PMID 2842691 DOI: 10.1038/335170A0  0.88
1985 Waldmann TA, Davis MM, Bongiovanni KF, Korsmeyer SJ. Rearrangements of genes for the antigen receptor on T cells as markers of lineage and clonality in human lymphoid neoplasms. The New England Journal of Medicine. 313: 776-83. PMID 2993886 DOI: 10.1056/NEJM198509263131303  0.32
1984 Korsmeyer SJ, Waldmann TA. Immunoglobulin genes: rearrangement and translocation in human lymphoid malignancy. Journal of Clinical Immunology. 4: 1-11. PMID 6421869 DOI: 10.1007/BF00915280  0.32
1984 Benjamin D, Magrath IT, Triche TJ, Schroff RW, Jensen JP, Korsmeyer SJ. Induction of plasmacytoid differentiation by phorbol ester in B-cell lymphoma cell lines bearing 8;14 translocations Proceedings of the National Academy of Sciences of the United States of America. 81: 3547-3551. PMID 6203124  0.88
1983 Korsmeyer SJ, Arnold A, Bakhshi A, Ravetch JV, Siebenlist U, Hieter PA, Sharrow SO, LeBien TW, Kersey JH, Poplack DG, Leder P, Waldmann TA. Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. The Journal of Clinical Investigation. 71: 301-13. PMID 6401769  0.88
1983 Taub RA, Hollis GF, Hieter PA, Korsmeyer S, Waldmann TA, Leder P. Variable amplification of immunoglobulin lambda light-chain genes in human populations. Nature. 304: 172-4. PMID 6306474 DOI: 10.1038/304172a0  0.88
1983 Korsmeyer SJ, Greene WC, Cossman J, Hsu SM, Jensen JP, Neckers LM, Marshall SL, Bakhshi A, Depper JM, Leonard WJ, Jaffe ES, Waldmann TA. Rearrangement and expression of immunoglobulin genes and expression of Tac antigen in hairy cell leukemia. Proceedings of the National Academy of Sciences of the United States of America. 80: 4522-6. PMID 6192435 DOI: 10.1073/pnas.80.14.4522  0.88
1982 Korsmeyer SJ, Hieter PA, Sharrow SO, Goldman CK, Leder P, Waldmann TA. Normal human B cells display ordered light chain gene rearrangements and deletions. The Journal of Experimental Medicine. 156: 975-85. PMID 6818320 DOI: 10.1084/jem.156.4.975  0.88
1982 Korsmeyer SJ, Elfenbein GJ, Goldman CK, Marshall SL, Santos GW, Waldmann TA. B cell, helper T cell, and suppressor T cell abnormalities contribute to disordered immunoglobulin synthesis in patients following bone marrow transplantation. Transplantation. 33: 184-90. PMID 6277055 DOI: 10.1097/00007890-198202000-00015  0.88
1981 Hieter PA, Korsmeyer SJ, Waldmann TA, Leder P. Human immunoglobulin kappa light-chain genes are deleted or rearranged in lambda-producing B cells. Nature. 290: 368-72. PMID 6783958 DOI: 10.1038/290368a0  0.88
1981 Korsmeyer SJ, Hieter PA, Ravetch JV, Poplack DG, Waldmann TA, Leder P. Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. Proceedings of the National Academy of Sciences of the United States of America. 78: 7096-100. PMID 6273911  0.88
1981 Hieter PA, Hollis GF, Korsmeyer SJ, Waldmann TA, Leder P. Clustered arrangement of immunoglobulin lambda constant region genes in man. Nature. 294: 536-40. PMID 6273747 DOI: 10.1038/294536a0  0.88
1981 Ravetch JV, Siebenlist U, Korsmeyer S, Waldmann T, Leder P. Structure of the human immunoglobulin mu locus: characterization of embryonic and rearranged J and D genes. Cell. 27: 583-91. PMID 6101209  0.88
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