Larry A. Sklar - Publications

University of New Mexico, Albuquerque, NM, United States 
Molecular Biology, Cell Biology

118 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Revankar CM, Bologa CG, Pepermans RA, Sharma G, Petrie WK, Alcon SN, Field AS, Ramesh C, Parker MA, Savchuk NP, Sklar LA, Hathaway HJ, Arterburn JB, Oprea TI, Prossnitz ER. A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling. Cell Chemical Biology. PMID 31706983 DOI: 10.1016/j.chembiol.2019.10.009  0.92
2018 Oprea TI, Jan L, Johnson GL, Roth BL, Ma'ayan A, Schürer S, Shoichet BK, Sklar LA, McManus MT. Far away from the lamppost. Plos Biology. 16: e3000067. PMID 30532236 DOI: 10.1371/journal.pbio.3000067  0.4
2018 Perez DR, Edwards BS, Sklar LA, Chigaev A. High-Throughput Flow Cytometry Drug Combination Discovery with Novel Synergy Analysis Software, SynScreen. Slas Discovery : Advancing Life Sciences R & D. 2472555218775913. PMID 29842834 DOI: 10.1177/2472555218775913  0.64
2018 Palsuledesai CC, Surviladze Z, Waller A, Miscioscia TF, Guo Y, Wu Y, Strouse J, Romero E, Salas VM, Curpan R, Young S, Carter M, Foutz T, Galochkina Z, Ames H, ... ... Sklar LA, et al. Activation of Rho-family GTPases by small molecules. Acs Chemical Biology. PMID 29746086 DOI: 10.1021/acschembio.8b00038  0.64
2018 Buranda T, Gineste C, Wu Y, Bondu V, Perez D, Lake KR, Edwards BS, Sklar LA. A High-Throughput Flow Cytometry Screen Identifies Molecules That Inhibit Hantavirus Cell Entry. Slas Discovery : Advancing Life Sciences R & D. 2472555218766623. PMID 29608398 DOI: 10.1177/2472555218766623  0.64
2018 Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A, Gomez SM, Guha R, Hersey A, Holmes J, Jadhav A, Jensen LJ, Johnson GL, Karlson A, Leach AR, ... ... Sklar LA, et al. Unexplored therapeutic opportunities in the human genome. Nature Reviews. Drug Discovery. PMID 29567993 DOI: 10.1038/nrd.2018.52  0.44
2018 Oprea TI, Bologa CG, Brunak S, Campbell A, Gan GN, Gaulton A, Gomez SM, Guha R, Hersey A, Holmes J, Jadhav A, Jensen LJ, Johnson GL, Karlson A, Leach AR, ... ... Sklar LA, et al. Unexplored therapeutic opportunities in the human genome. Nature Reviews. Drug Discovery. PMID 29472638 DOI: 10.1038/nrd.2018.14  0.44
2018 Haynes MK, Garcia M, Peters R, Waller A, Tedesco P, Ursu O, Bologa CG, Santos RG, Pinilla C, Wu TH, Lovchik JA, Oprea TI, Sklar LA, Tegos GP. High-Throughput Flow Cytometry Screening of Multidrug Efflux Systems. Methods in Molecular Biology (Clifton, N.J.). 1700: 293-318. PMID 29177837 DOI: 10.1007/978-1-4939-7454-2_16  0.44
2017 Bredemeyer AL, Edwards BS, Haynes MK, Morales AJ, Wang Y, Ursu O, Waller A, Sklar LA, Sleckman BP. High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining. Slas Discovery : Advancing Life Sciences R & D. 2472555217746324. PMID 29232168 DOI: 10.1177/2472555217746324  0.64
2017 Cannon DC, Yang JJ, Mathias SL, Ursu O, Mani S, Waller A, Schürer SC, Jensen LJ, Sklar LA, Bologa CG, Oprea TI. TIN-X: Target Importance and Novelty Explorer. Bioinformatics (Oxford, England). PMID 28398460 DOI: 10.1093/bioinformatics/btx200  0.44
2016 Nguyen DT, Mathias S, Bologa C, Brunak S, Fernandez N, Gaulton A, Hersey A, Holmes J, Jensen LJ, Karlsson A, Liu G, Ma'ayan A, Mandava G, Mani S, Mehta S, ... ... Sklar LA, et al. Pharos: Collating protein information to shed light on the druggable genome. Nucleic Acids Research. PMID 27903890 DOI: 10.1093/nar/gkw1072  0.4
2016 Yang JJ, Ursu O, Lipinski CA, Sklar LA, Oprea TI, Bologa CG. Badapple: promiscuity patterns from noisy evidence. Journal of Cheminformatics. 8: 29. PMID 27239230 DOI: 10.1186/s13321-016-0137-3  0.44
2015 Oprea TI, Sklar LA, Agola JO, Guo Y, Silberberg M, Roxby J, Vestling A, Romero E, Surviladze Z, Murray-Krezan C, Waller A, Ursu O, Hudson LG, Wandinger-Ness A. Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases. Plos One. 10: e0142182. PMID 26558612 DOI: 10.1371/journal.pone.0142182  0.4
2015 Wu Y, Stauffer SR, Stanfield RL, Tapia PH, Ursu O, Fisher GW, Szent-Gyorgyi C, Evangelisti A, Waller A, Strouse JJ, Carter MB, Bologa C, Gouveia K, Poslusney M, Waggoner AS, ... ... Sklar LA, et al. Discovery of Small-Molecule Nonfluorescent Inhibitors of Fluorogen-Fluorogen Activating Protein Binding Pair. Journal of Biomolecular Screening. PMID 26442911 DOI: 10.1177/1087057115609145  0.68
2015 Hong L, Guo Y, BasuRay S, Agola JO, Romero E, Simpson DS, Schroeder CE, Simons P, Waller A, Garcia M, Carter M, Ursu O, Gouveia K, Golden JE, Aubé J, ... ... Sklar LA, et al. A Pan-GTPase Inhibitor as a Molecular Probe. Plos One. 10: e0134317. PMID 26247207 DOI: 10.1371/journal.pone.0134317  0.68
2015 Guo Y, Kenney SR, Cook LS, Adams SF, Rutledge T, Romero E, Oprea T, Sklar LA, Bedrick E, Wiggins CL, Kang H, Lomo L, Muller CY, Wandinger-Ness A, Hudson LG. A novel pharmacologic activity of ketorolac for therapeutic benefit in ovarian cancer patients. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 26071482 DOI: 10.1158/1078-0432.CCR-15-0461  0.4
2015 Schreiber SL, Kotz JD, Li M, Aubé J, Austin CP, Reed JC, Rosen H, White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, de Souza A, Foley MA, et al. Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes. Cell. 161: 1252-1265. PMID 26046436 DOI: 10.1016/j.cell.2015.05.023  0.68
2015 Edwards BS, Sklar LA. Flow Cytometry: Impact on Early Drug Discovery. Journal of Biomolecular Screening. 20: 689-707. PMID 25805180 DOI: 10.1177/1087057115578273  0.68
2015 Agola JO, Sivalingam D, Cimino DF, Simons PC, Buranda T, Sklar LA, Wandinger-Ness A. Quantitative bead-based flow cytometry for assaying Rab7 GTPase interaction with the Rab-interacting lysosomal protein (RILP) effector protein. Methods in Molecular Biology (Clifton, N.J.). 1298: 331-54. PMID 25800855 DOI: 10.1007/978-1-4939-2569-8_28  0.68
2015 Hong L, Chavez S, Smagley Y, Chigaev A, Sklar LA. Relationship of light scatter change and Cdc42-regulated actin status. Cytometry. Part B, Clinical Cytometry. PMID 25641607 DOI: 10.1002/cyto.b.21223  0.68
2015 Zhao Z, Haynes MK, Ursu O, Edwards BS, Sklar LA, Zweifach A. A high-throughput phenotypic screen of cytotoxic T lymphocyte lytic granule exocytosis reveals candidate immunosuppressants. Journal of Biomolecular Screening. 20: 359-71. PMID 25381253 DOI: 10.1177/1087057114557620  0.68
2015 Chigaev A, Smagley Y, Haynes MK, Ursu O, Bologa CG, Halip L, Oprea T, Waller A, Carter MB, Zhang Y, Wang W, Buranda T, Sklar LA. FRET detection of lymphocyte function-associated antigen-1 conformational extension. Molecular Biology of the Cell. 26: 43-54. PMID 25378583 DOI: 10.1091/mbc.E14-06-1050  0.68
2014 Bernardo SM, Allen CP, Waller A, Young SM, Oprea T, Sklar LA, Lee SA. An automated high-throughput cell-based multiplexed flow cytometry assay to identify novel compounds to target Candida albicans virulence-related proteins. Plos One. 9: e110354. PMID 25350399 DOI: 10.1371/journal.pone.0110354  0.68
2014 Cordero D, Fullenkamp CR, Pelly RR, Reed KM, Caffo LM, Zahrt AN, Newman M, Komanapalli S, Niemeier EM, Bishop DL, Bruns HA, Haynes MK, Sklar LA, Sammelson RE, McDowell SA. Small Molecule Inhibitors Limit Endothelial Cell Invasion by Staphylococcus aureus. Current Pharmaceutical Biotechnology. 15: 727-37. PMID 25213310  0.68
2014 Tegos GP, Evangelisti AM, Strouse JJ, Ursu O, Bologa C, Sklar LA. A high throughput flow cytometric assay platform targeting transporter inhibition. Drug Discovery Today. Technologies. 12: e95-103. PMID 25027381 DOI: 10.1016/j.ddtec.2014.03.010  0.68
2014 Sully EK, Malachowa N, Elmore BO, Alexander SM, Femling JK, Gray BM, DeLeo FR, Otto M, Cheung AL, Edwards BS, Sklar LA, Horswill AR, Hall PR, Gresham HD. Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance. Plos Pathogens. 10: e1004174. PMID 24945495 DOI: 10.1371/journal.ppat.1004174  0.68
2014 Hill JW, Thompson JF, Carter MB, Edwards BS, Sklar LA, Rosenberg GA. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. Plos One. 9: e96761. PMID 24804769 DOI: 10.1371/journal.pone.0096761  0.68
2014 Smurthwaite CA, Hilton BJ, O'Hanlon R, Stolp ZD, Hancock BM, Abbadessa D, Stotland A, Sklar LA, Wolkowicz R. Fluorescent genetic barcoding in mammalian cells for enhanced multiplexing capabilities in flow cytometry. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 85: 105-13. PMID 24700576 DOI: 10.1002/cyto.a.22406  0.68
2014 Wu Y, Tapia PH, Jarvik J, Waggoner AS, Sklar LA. Real-time detection of protein trafficking with high-throughput flow cytometry (HTFC) and fluorogen-activating protein (FAP) base biosensor. Current Protocols in Cytometry / Editorial Board, J. Paul Robinson, Managing Editor ... [Et Al.]. 67: Unit 9.43.. PMID 24510772 DOI: 10.1002/0471142956.cy0943s67  0.68
2014 Edwards BS, Gouveia K, Oprea TI, Sklar LA. The University of New Mexico Center for Molecular Discovery. Combinatorial Chemistry & High Throughput Screening. 17: 256-65. PMID 24409953  0.64
2013 Pinilla C, Edwards BS, Appel JR, Yates-Gibbins T, Giulianotti MA, Medina-Franco JL, Young SM, Santos RG, Sklar LA, Houghten RA. Selective agonists and antagonists of formylpeptide receptors: duplex flow cytometry and mixture-based positional scanning libraries. Molecular Pharmacology. 84: 314-24. PMID 23788657 DOI: 10.1124/mol.113.086595  0.68
2013 Santos RG, Appel JR, Giulianotti MA, Edwards BS, Sklar LA, Houghten RA, Pinilla C. The mathematics of a successful deconvolution: a quantitative assessment of mixture-based combinatorial libraries screened against two formylpeptide receptors. Molecules (Basel, Switzerland). 18: 6408-24. PMID 23722730 DOI: 10.3390/molecules18066408  0.68
2013 Medina-Franco JL, Edwards BS, Pinilla C, Appel JR, Giulianotti MA, Santos RG, Yongye AB, Sklar LA, Houghten RA. Rapid scanning structure-activity relationships in combinatorial data sets: identification of activity switches. Journal of Chemical Information and Modeling. 53: 1475-85. PMID 23705689 DOI: 10.1021/ci400192y  0.68
2013 Strouse JJ, Ivnitski-Steele I, Waller A, Young SM, Perez D, Evangelisti AM, Ursu O, Bologa CG, Carter MB, Salas VM, Tegos G, Larson RS, Oprea TI, Edwards BS, Sklar LA. Fluorescent substrates for flow cytometric evaluation of efflux inhibition in ABCB1, ABCC1, and ABCG2 transporters. Analytical Biochemistry. 437: 77-87. PMID 23470221 DOI: 10.1016/j.ab.2013.02.018  0.68
2013 Hong L, Kenney SR, Phillips GK, Simpson D, Schroeder CE, Nöth J, Romero E, Swanson S, Waller A, Strouse JJ, Carter M, Chigaev A, Ursu O, Oprea T, Hjelle B, ... ... Sklar LA, et al. Characterization of a Cdc42 protein inhibitor and its use as a molecular probe. The Journal of Biological Chemistry. 288: 8531-43. PMID 23382385 DOI: 10.1074/jbc.M112.435941  0.68
2013 Wu Y, Tapia PH, Fisher GW, Waggoner AS, Jarvik J, Sklar LA. High-throughput flow cytometry compatible biosensor based on fluorogen activating protein technology. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 83: 220-6. PMID 23303704 DOI: 10.1002/cyto.a.22242  0.68
2013 Florian AE, Lepensky CK, Kwon O, Haynes MK, Sklar LA, Zweifach A. Flow cytometry enables a high-throughput homogeneous fluorescent antibody-binding assay for cytotoxic T cell lytic granule exocytosis. Journal of Biomolecular Screening. 18: 420-9. PMID 23160568 DOI: 10.1177/1087057112466697  0.68
2013 Strouse JJ, Ivnitski-Steele I, Khawaja HM, Perez D, Ricci J, Yao T, Weiner WS, Schroeder CE, Simpson DS, Maki BE, Li K, Golden JE, Foutz TD, Waller A, Evangelisti AM, ... ... Sklar LA, et al. A selective ATP-binding cassette subfamily G member 2 efflux inhibitor revealed via high-throughput flow cytometry. Journal of Biomolecular Screening. 18: 26-38. PMID 22923785 DOI: 10.1177/1087057112456875  0.68
2012 Thal DM, Homan KT, Chen J, Wu EK, Hinkle PM, Huang ZM, Chuprun JK, Song J, Gao E, Cheung JY, Sklar LA, Koch WJ, Tesmer JJ. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. Acs Chemical Biology. 7: 1830-9. PMID 22882301 DOI: 10.1021/cb3003013  0.68
2012 Polireddy K, Khan MM, Chavan H, Young S, Ma X, Waller A, Garcia M, Perez D, Chavez S, Strouse JJ, Haynes MK, Bologa CG, Oprea TI, Tegos GP, Sklar LA, et al. A novel flow cytometric HTS assay reveals functional modulators of ATP binding cassette transporter ABCB6. Plos One. 7: e40005. PMID 22808084 DOI: 10.1371/journal.pone.0040005  0.68
2012 Wu Y, Tapia PH, Fisher GW, Simons PC, Strouse JJ, Foutz T, Waggoner AS, Jarvik J, Sklar LA. Discovery of regulators of receptor internalization with high-throughput flow cytometry. Molecular Pharmacology. 82: 645-57. PMID 22767611 DOI: 10.1124/mol.112.079897  0.68
2012 Agola JO, Hong L, Surviladze Z, Ursu O, Waller A, Strouse JJ, Simpson DS, Schroeder CE, Oprea TI, Golden JE, Aubé J, Buranda T, Sklar LA, Wandinger-Ness A. A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition. Acs Chemical Biology. 7: 1095-108. PMID 22486388 DOI: 10.1021/cb3001099  0.68
2012 Edwards BS, Zhu J, Chen J, Carter MB, Thal DM, Tesmer JJ, Graves SW, Sklar LA. Cluster cytometry for high-capacity bioanalysis. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 81: 419-29. PMID 22438314 DOI: 10.1002/cyto.a.22039  0.68
2012 Chen J, Young SM, Allen C, Seeber A, Péli-Gulli MP, Panchaud N, Waller A, Ursu O, Yao T, Golden JE, Strouse JJ, Carter MB, Kang H, Bologa CG, Foutz TD, ... ... Sklar LA, et al. Identification of a small molecule yeast TORC1 inhibitor with a multiplex screen based on flow cytometry. Acs Chemical Biology. 7: 715-22. PMID 22260433 DOI: 10.1021/cb200452r  0.84
2012 Chan CY, Prudom C, Raines SM, Charkhzarrin S, Melman SD, De Haro LP, Allen C, Lee SA, Sklar LA, Parra KJ. Inhibitors of V-ATPase proton transport reveal uncoupling functions of tether linking cytosolic and membrane domains of V0 subunit a (Vph1p). The Journal of Biological Chemistry. 287: 10236-50. PMID 22215674 DOI: 10.1074/jbc.M111.321133  0.68
2012 Surviladze Z, Young SM, Sklar LA. High-throughput flow cytometry bead-based multiplex assay for identification of Rho GTPase inhibitors. Methods in Molecular Biology (Clifton, N.J.). 827: 253-70. PMID 22144280 DOI: 10.1007/978-1-61779-442-1_17  0.68
2012 Chen J, Carter MB, Edwards BS, Cai H, Sklar LA. High throughput flow cytometry based yeast two-hybrid array approach for large-scale analysis of protein-protein interactions. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 81: 90-8. PMID 21954189 DOI: 10.1002/cyto.a.21144  0.68
2011 Oprea TI, Bauman JE, Bologa CG, Buranda T, Chigaev A, Edwards BS, Jarvik JW, Gresham HD, Haynes MK, Hjelle B, Hromas R, Hudson L, Mackenzie DA, Muller CY, Reed JC, ... ... Sklar LA, et al. Drug Repurposing from an Academic Perspective. Drug Discovery Today. Therapeutic Strategies. 8: 61-69. PMID 22368688 DOI: 10.1016/j.ddstr.2011.10.002  0.68
2011 Oprea TI, Nielsen SK, Ursu O, Yang JJ, Taboureau O, Mathias SL, Kouskoumvekaki L, Sklar LA, Bologa CG. Associating Drugs, Targets and Clinical Outcomes into an Integrated Network Affords a New Platform for Computer-Aided Drug Repurposing. Molecular Informatics. 30: 100-111. PMID 22287994 DOI: 10.1002/minf.201100023  0.68
2011 Zwartz GJ, Chigaev A, Foutz TD, Edwards B, Sklar LA. A miniature Couette to generate shear for flow cytometry: studying real-time modulation of intracellular calcium in monocytic cells. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 79: 233-40. PMID 22045643 DOI: 10.1002/cyto.a.21027  0.84
2011 Dennis MK, Field AS, Burai R, Ramesh C, Petrie WK, Bologa CG, Oprea TI, Yamaguchi Y, Hayashi S, Sklar LA, Hathaway HJ, Arterburn JB, Prossnitz ER. Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. The Journal of Steroid Biochemistry and Molecular Biology. 127: 358-66. PMID 21782022 DOI: 10.1016/j.jsbmb.2011.07.002  0.68
2011 Simons PC, Young SM, Carter MB, Waller A, Zhai D, Reed JC, Edwards BS, Sklar LA. Simultaneous in vitro molecular screening of protein-peptide interactions by flow cytometry, using six Bcl-2 family proteins as examples. Nature Protocols. 6: 943-52. PMID 21720309 DOI: 10.1038/nprot.2011.339  0.68
2011 Curpan RF, Simons PC, Zhai D, Young SM, Carter MB, Bologa CG, Oprea TI, Satterthwait AC, Reed JC, Edwards BS, Sklar LA. High-throughput screen for the chemical inhibitors of antiapoptotic bcl-2 family proteins by multiplex flow cytometry. Assay and Drug Development Technologies. 9: 465-74. PMID 21561376 DOI: 10.1089/adt.2010.0363  0.68
2011 Chigaev A, Smagley Y, Zhang Y, Waller A, Haynes MK, Amit O, Wang W, Larson RS, Sklar LA. Real-time analysis of the inside-out regulation of lymphocyte function-associated antigen-1 revealed similarities to and differences from very late antigen-4. The Journal of Biological Chemistry. 286: 20375-86. PMID 21515675 DOI: 10.1074/jbc.M110.206185  0.68
2011 Tegos GP, Haynes M, Strouse JJ, Khan MM, Bologa CG, Oprea TI, Sklar LA. Microbial efflux pump inhibition: tactics and strategies. Current Pharmaceutical Design. 17: 1291-302. PMID 21470111  0.68
2011 Gros R, Ding Q, Sklar LA, Prossnitz EE, Arterburn JB, Chorazyczewski J, Feldman RD. GPR30 expression is required for the mineralocorticoid receptor-independent rapid vascular effects of aldosterone. Hypertension. 57: 442-51. PMID 21242460 DOI: 10.1161/HYPERTENSIONAHA.110.161653  0.68
2011 Chigaev A, Wu Y, Williams DB, Smagley Y, Sklar LA. Discovery of very late antigen-4 (VLA-4, alpha4beta1 integrin) allosteric antagonists. The Journal of Biological Chemistry. 286: 5455-63. PMID 21131351 DOI: 10.1074/jbc.M110.162636  0.68
2010 Saunders MJ, Edwards BS, Zhu J, Sklar LA, Graves SW. Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. Current Protocols in Cytometry / Editorial Board, J. Paul Robinson, Managing Editor ... [Et Al.]. Unit 13.12.1-17. PMID 20938917 DOI: 10.1002/0471142956.cy1312s54  0.68
2010 Nayak TK, Dennis MK, Ramesh C, Burai R, Atcher RW, Sklar LA, Norenberg JP, Hathaway HJ, Arterburn JB, Prossnitz ER. Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents. Acs Chemical Biology. 5: 681-90. PMID 20486699 DOI: 10.1021/cb1000636  0.68
2010 Burai R, Ramesh C, Shorty M, Curpan R, Bologa C, Sklar LA, Oprea T, Prossnitz ER, Arterburn JB. Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs. Organic & Biomolecular Chemistry. 8: 2252-9. PMID 20401403 DOI: 10.1039/c001307b  0.68
2010 Buranda T, Wu Y, Perez D, Jett SD, BonduHawkins V, Ye C, Edwards B, Hall P, Larson RS, Lopez GP, Sklar LA, Hjelle B. Recognition of decay accelerating factor and alpha(v)beta(3) by inactivated hantaviruses: Toward the development of high-throughput screening flow cytometry assays. Analytical Biochemistry. 402: 151-60. PMID 20363206 DOI: 10.1016/j.ab.2010.03.016  0.68
2010 Ramesh C, Nayak TK, Burai R, Dennis MK, Hathaway HJ, Sklar LA, Prossnitz ER, Arterburn JB. Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30. Journal of Medicinal Chemistry. 53: 1004-14. PMID 20041667 DOI: 10.1021/jm9011802  0.68
2010 Saunders MJ, Graves SW, Sklar LA, Oprea TI, Edwards BS. High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. Assay and Drug Development Technologies. 8: 37-46. PMID 20035615 DOI: 10.1089/adt.2009.0219  0.68
2010 Johnson RM, Allen C, Melman SD, Waller A, Young SM, Sklar LA, Parra KJ. Identification of inhibitors of vacuolar proton-translocating ATPase pumps in yeast by high-throughput screening flow cytometry. Analytical Biochemistry. 398: 203-11. PMID 20018164 DOI: 10.1016/j.ab.2009.12.020  0.68
2010 Surviladze Z, Waller A, Wu Y, Romero E, Edwards BS, Wandinger-Ness A, Sklar LA. Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay. Journal of Biomolecular Screening. 15: 10-20. PMID 20008126 DOI: 10.1177/1087057109352240  0.64
2009 Guo H, Yang J, Gallazzi F, Prossnitz ER, Sklar LA, Miao Y. Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide. Bioconjugate Chemistry. 20: 2162-8. PMID 19817405 DOI: 10.1021/bc9003475  0.92
2009 Arterburn JB, Oprea TI, Prossnitz ER, Edwards BS, Sklar LA. Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30. Current Topics in Medicinal Chemistry. 9: 1227-36. PMID 19807662 DOI: 10.2174/156802609789753608  0.68
2009 Njus BH, Chigaev A, Waller A, Wlodek D, Ostopovici-Halip L, Ursu O, Wang W, Oprea TI, Bologa CG, Sklar LA. Conformational mAb as a tool for integrin ligand discovery. Assay and Drug Development Technologies. 7: 507-15. PMID 19754304 DOI: 10.1089/adt.2009.0203  0.44
2009 Oprea TI, Bologa CG, Boyer S, Curpan RF, Glen RC, Hopkins AL, Lipinski CA, Marshall GR, Martin YC, Ostopovici-Halip L, Rishton G, Ursu O, Vaz RJ, Waller C, Waldmann H, ... Sklar LA, et al. A crowdsourcing evaluation of the NIH chemical probes. Nature Chemical Biology. 5: 441-7. PMID 19536101 DOI: 10.1038/nchembio0709-441  0.68
2009 Haynes MK, Strouse JJ, Waller A, Leitao A, Curpan RF, Bologa C, Oprea TI, Prossnitz ER, Edwards BS, Sklar LA, Thompson TA. Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system. Journal of Biomolecular Screening. 14: 596-609. PMID 19470718 DOI: 10.1177/1087057109335671  0.68
2009 Dennis MK, Burai R, Ramesh C, Petrie WK, Alcon SN, Nayak TK, Bologa CG, Leitao A, Brailoiu E, Deliu E, Dun NJ, Sklar LA, Hathaway HJ, Arterburn JB, Oprea TI, et al. In vivo effects of a GPR30 antagonist. Nature Chemical Biology. 5: 421-7. PMID 19430488 DOI: 10.1038/nchembio.168  0.68
2009 Edwards BS, Young SM, Ivnitsky-Steele I, Ye RD, Prossnitz ER, Sklar LA. High-content screening: flow cytometry analysis. Methods in Molecular Biology (Clifton, N.J.). 486: 151-65. PMID 19347622 DOI: 10.1007/978-1-60327-545-3_11  0.92
2009 Chigaev A, Waller A, Amit O, Halip L, Bologa CG, Sklar LA. Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation. The Journal of Biological Chemistry. 284: 14337-46. PMID 19251697 DOI: 10.1074/jbc.M901178200  0.68
2009 Strouse JJ, Young SM, Mitchell HD, Ye RD, Prossnitz ER, Sklar LA, Edwards BS. A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 75: 264-70. PMID 19006074 DOI: 10.1002/cyto.a.20670  0.68
2009 Young SM, Bologa CM, Fara D, Bryant BK, Strouse JJ, Arterburn JB, Ye RD, Oprea TI, Prossnitz ER, Sklar LA, Edwards BS. Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 75: 253-63. PMID 18785269 DOI: 10.1002/cyto.a.20645  0.68
2008 Schwartz SL, Tessema M, Buranda T, Pylypenko O, Rak A, Simons PC, Surviladze Z, Sklar LA, Wandinger-Ness A. Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases. Analytical Biochemistry. 381: 258-66. PMID 18638444 DOI: 10.1016/j.ab.2008.06.039  0.68
2008 Chigaev A, Waller A, Amit O, Sklar LA. Galphas-coupled receptor signaling actively down-regulates alpha4beta1-integrin affinity: a possible mechanism for cell de-adhesion. Bmc Immunology. 9: 26. PMID 18534032 DOI: 10.1186/1471-2172-9-26  0.68
2008 Nayak TK, Hathaway HJ, Ramesh C, Arterburn JB, Dai D, Sklar LA, Norenberg JP, Prossnitz ER. Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 49: 978-86. PMID 18483091 DOI: 10.2967/jnumed.107.048546  0.68
2008 Salas VM, Edwards BS, Sklar LA. Advances in multiple analyte profiling. Advances in Clinical Chemistry. 45: 47-74. PMID 18429493  0.64
2008 Prossnitz ER, Oprea TI, Sklar LA, Arterburn JB. The ins and outs of GPR30: a transmembrane estrogen receptor. The Journal of Steroid Biochemistry and Molecular Biology. 109: 350-3. PMID 18406603 DOI: 10.1016/j.jsbmb.2008.03.006  0.68
2008 Dennis MK, Bowles HJ, MacKenzie DA, Burchiel SW, Edwards BS, Sklar LA, Prossnitz ER, Thompson TA. A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 73: 390-9. PMID 18340645 DOI: 10.1002/cyto.a.20552  0.92
2008 Winter SS, Lovato DM, Khawaja HM, Edwards BS, Steele ID, Young SM, Oprea TI, Sklar LA, Larson RS. High-throughput screening for daunorubicin-mediated drug resistance identifies mometasone furoate as a novel ABCB1-reversal agent. Journal of Biomolecular Screening. 13: 185-93. PMID 18310528 DOI: 10.1177/1087057108314610  0.64
2008 Zeineldin R, Piyasena ME, Sklar LA, Whitten D, Lopez GP. Detection of membrane biointeractions based on fluorescence superquenching. Langmuir : the Acs Journal of Surfaces and Colloids. 24: 4125-31. PMID 18302435 DOI: 10.1021/la703575r  0.68
2008 Prossnitz ER, Arterburn JB, Smith HO, Oprea TI, Sklar LA, Hathaway HJ. Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annual Review of Physiology. 70: 165-90. PMID 18271749 DOI: 10.1146/annurev.physiol.70.113006.100518  0.68
2008 Prossnitz ER, Sklar LA, Oprea TI, Arterburn JB. GPR30: a novel therapeutic target in estrogen-related disease. Trends in Pharmacological Sciences. 29: 116-23. PMID 18262661 DOI: 10.1016/  0.68
2008 Ivnitski-Steele I, Larson RS, Lovato DM, Khawaja HM, Winter SS, Oprea TI, Sklar LA, Edwards BS. High-throughput flow cytometry to detect selective inhibitors of ABCB1, ABCC1, and ABCG2 transporters. Assay and Drug Development Technologies. 6: 263-76. PMID 18205550 DOI: 10.1089/adt.2007.107  0.64
2007 Edwards BS, Young SM, Saunders MJ, Bologa C, Oprea TI, Ye RD, Prossnitz ER, Graves SW, Sklar LA. High-throughput flow cytometry for drug discovery. Expert Opinion On Drug Discovery. 2: 685-96. PMID 23488958 DOI: 10.1517/17460441.2.5.685  0.68
2007 Edwards BS, Ivnitski-Steele I, Young SM, Salas VM, Sklar LA. High-throughput cytotoxicity screening by propidium iodide staining. Current Protocols in Cytometry / Editorial Board, J. Paul Robinson, Managing Editor ... [Et Al.]. Unit9.24. PMID 18770858 DOI: 10.1002/0471142956.cy0924s41  0.64
2007 Wu Y, Buranda T, Simons PC, Lopez GP, McIntire WE, Garrison JC, Prossnitz ER, Sklar LA. Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides. Analytical Biochemistry. 371: 10-20. PMID 17904091 DOI: 10.1016/j.ab.2007.08.011  0.92
2007 Buranda T, Waller A, Wu Y, Simons PC, Biggs S, Prossnitz ER, Sklar LA. Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads. Advances in Protein Chemistry. 74: 95-135. PMID 17854656 DOI: 10.1016/S0065-3233(07)74003-2  0.92
2007 Revankar CM, Mitchell HD, Field AS, Burai R, Corona C, Ramesh C, Sklar LA, Arterburn JB, Prossnitz ER. Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. Acs Chemical Biology. 2: 536-44. PMID 17655271 DOI: 10.1021/cb700072n  0.68
2007 Sklar LA, Carter MB, Edwards BS. Flow cytometry for drug discovery, receptor pharmacology and high-throughput screening Current Opinion in Pharmacology. 7: 527-534. PMID 17652026 DOI: 10.1016/j.coph.2007.06.006  0.68
2007 Simons PC, Young SM, Gibaja V, Lee WC, Josiah S, Edwards BS, Sklar LA. Duplexed, bead-based competitive assay for inhibitors of protein kinases. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 71: 451-9. PMID 17542028 DOI: 10.1002/cyto.a.20398  0.64
2007 Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, Prossnitz ER, Dun NJ. Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. The Journal of Endocrinology. 193: 311-21. PMID 17470522 DOI: 10.1677/JOE-07-0017  0.68
2007 Prossnitz ER, Arterburn JB, Sklar LA. GPR30: A G protein-coupled receptor for estrogen. Molecular and Cellular Endocrinology. 265: 138-42. PMID 17222505 DOI: 10.1016/j.mce.2006.12.010  0.68
2006 Prossnitz ER, Arterburn JB, Edwards BS, Sklar LA, Oprea TI. Steroid-binding G-protein-coupled receptors: new drug discovery targets for old ligands. Expert Opinion On Drug Discovery. 1: 137-50. PMID 23495797 DOI: 10.1517/17460441.1.2.137  0.68
2006 Prossnitz ER, Sklar LA. Modulation of GPCR conformations by ligands, G-proteins, and arrestins. Ernst Schering Foundation Symposium Proceedings. 211-28. PMID 17703584  0.92
2006 Edwards BS, Young SM, Oprea TI, Bologa CG, Prossnitz ER, Sklar LA. Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform. Nature Protocols. 1: 59-66. PMID 17406212 DOI: 10.1038/nprot.2006.9  0.92
2006 Ramesh C, Bryant B, Nayak T, Revankar CM, Anderson T, Carlson KE, Katzenellenbogen JA, Sklar LA, Norenberg JP, Prossnitz ER, Arterburn JB. Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates. Journal of the American Chemical Society. 128: 14476-7. PMID 17090028 DOI: 10.1021/ja066360p  0.68
2006 Saunders MJ, Kim H, Woods TA, Nolan JP, Sklar LA, Edwards BS, Graves SW. Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 69: 342-52. PMID 16604538 DOI: 10.1002/cyto.a.20268  0.68
2006 Zeineldin R, Piyasena ME, Bergstedt TS, Sklar LA, Whitten D, Lopez GP. Superquenching as a detector for microsphere-based flow cytometric assays. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 69: 335-41. PMID 16604535 DOI: 10.1002/cyto.a.20250  0.68
2006 Tessema M, Simons PC, Cimino DF, Sanchez L, Waller A, Posner RG, Wandinger-Ness A, Prossnitz ER, Sklar LA. Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 69: 326-34. PMID 16604533 DOI: 10.1002/cyto.a.20259  0.68
2006 Bologa CG, Revankar CM, Young SM, Edwards BS, Arterburn JB, Kiselyov AS, Parker MA, Tkachenko SE, Savchuck NP, Sklar LA, Oprea TI, Prossnitz ER. Virtual and biomolecular screening converge on a selective agonist for GPR30. Nature Chemical Biology. 2: 207-12. PMID 16520733 DOI: 10.1038/nchembio775  0.68
2005 Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz ER, Savchuck NP, Sklar LA, Oprea TI. Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Molecular Pharmacology. 68: 1301-10. PMID 16118363 DOI: 10.1124/mol.105.014068  0.92
2005 Oprea TI, Bologa CG, Edwards BS, Prossnitz ER, Sklar LA. Post-high-throughput screening analysis: an empirical compound prioritization scheme. Journal of Biomolecular Screening. 10: 419-26. PMID 16093551 DOI: 10.1177/1087057104272660  0.92
2005 Young SM, Bologa C, Prossnitz ER, Oprea TI, Sklar LA, Edwards BS. High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands. Journal of Biomolecular Screening. 10: 374-82. PMID 15964939 DOI: 10.1177/1087057105274532  0.92
2005 Babbitt SE, Kiss A, Deffenbaugh AE, Chang YH, Bailly E, Erdjument-Bromage H, Tempst P, Buranda T, Sklar LA, Baumler J, Gogol E, Skowyra D. ATP hydrolysis-dependent disassembly of the 26S proteasome is part of the catalytic cycle. Cell. 121: 553-65. PMID 15907469 DOI: 10.1016/j.cell.2005.03.028  0.68
2005 Larson RS, Davis T, Bologa C, Semenuk G, Vijayan S, Li Y, Oprea T, Chigaev A, Buranda T, Wagner CR, Sklar LA. Dissociation of I domain and global conformational changes in LFA-1: refinement of small molecule-I domain structure-activity relationships. Biochemistry. 44: 4322-31. PMID 15766261 DOI: 10.1021/bi048187k  0.68
2005 Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science (New York, N.Y.). 307: 1625-30. PMID 15705806 DOI: 10.1126/science.1106943  0.68
2005 Key TA, Vines CM, Wagener BM, Gurevich VV, Sklar LA, Prossnitz ER. Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins. Traffic (Copenhagen, Denmark). 6: 87-99. PMID 15634210 DOI: 10.1111/j.1600-0854.2004.00248.x  0.92
2004 Waller A, Simons PC, Biggs SM, Edwards BS, Prossnitz ER, Sklar LA. Techniques: GPCR assembly, pharmacology and screening by flow cytometry. Trends in Pharmacological Sciences. 25: 663-9. PMID 15530645 DOI: 10.1016/  0.92
2004 Edwards BS, Oprea T, Prossnitz ER, Sklar LA. Flow cytometry for high-throughput, high-content screening. Current Opinion in Chemical Biology. 8: 392-8. PMID 15288249 DOI: 10.1016/j.cbpa.2004.06.007  0.92
2003 Key TA, Foutz TD, Gurevich VV, Sklar LA, Prossnitz ER. N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity. The Journal of Biological Chemistry. 278: 4041-7. PMID 12424254 DOI: 10.1074/jbc.M204687200  0.92
2002 Potter RM, Key TA, Gurevich VV, Sklar LA, Prossnitz ER. Arrestin variants display differential binding characteristics for the phosphorylated N-formyl peptide receptor carboxyl terminus. The Journal of Biological Chemistry. 277: 8970-8. PMID 11777932 DOI: 10.1074/jbc.M111086200  0.92
2001 Key TA, Bennett TA, Foutz TD, Gurevich VV, Sklar LA, Prossnitz ER. Regulation of formyl peptide receptor agonist affinity by reconstitution with arrestins and heterotrimeric G proteins. The Journal of Biological Chemistry. 276: 49204-12. PMID 11598142 DOI: 10.1074/jbc.M109475200  0.68
2001 Bennett TA, Key TA, Gurevich VV, Neubig R, Prossnitz ER, Sklar LA. Real-time analysis of G protein-coupled receptor reconstitution in a solubilized system. The Journal of Biological Chemistry. 276: 22453-60. PMID 11309376 DOI: 10.1074/jbc.M009679200  0.68
1999 Gilbert TL, Prossnitz ER, Sklar LA. The uncoupled state of the human formyl peptide receptor. Journal of Receptor and Signal Transduction Research. 19: 327-40. PMID 10071768 DOI: 10.3109/10799899909036655  0.68
1999 Prossnitz ER, Gilbert TL, Chiang S, Campbell JJ, Qin S, Newman W, Sklar LA, Ye RD. Multiple activation steps of the N-formyl peptide receptor. Biochemistry. 38: 2240-7. PMID 10029516 DOI: 10.1021/bi982274t  0.68
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