Eric R. Prossnitz - Publications

Affiliations: 
University of New Mexico, Albuquerque, NM, United States 
Area:
Molecular Biology, Cell Biology

104 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Sharma G, Hu C, Staquicini DI, Brigman JL, Liu M, Mauvais-Jarvis F, Pasqualini R, Arap W, Arterburn JB, Hathaway HJ, Prossnitz ER. Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes. Science Translational Medicine. 12. PMID 31996464 DOI: 10.1126/scitranslmed.aau5956  0.44
2019 Revankar CM, Bologa CG, Pepermans RA, Sharma G, Petrie WK, Alcon SN, Field AS, Ramesh C, Parker MA, Savchuk NP, Sklar LA, Hathaway HJ, Arterburn JB, Oprea TI, Prossnitz ER. A Selective Ligand for Estrogen Receptor Proteins Discriminates Rapid and Genomic Signaling. Cell Chemical Biology. PMID 31706983 DOI: 10.1016/j.chembiol.2019.10.009  0.56
2019 Triplett KD, Pokhrel S, Castleman MJ, Daly SM, Elmore BO, Joyner JA, Sharma G, Herbert G, Campen MJ, Hathaway HJ, Prossnitz ER, Hall PR. GPER activation protects against epithelial barrier disruption by Staphylococcus aureus α-toxin. Scientific Reports. 9: 1343. PMID 30718654 DOI: 10.1038/s41598-018-37951-3  0.36
2017 Castleman MJ, Pokhrel S, Triplett KD, Kusewitt DF, Elmore BO, Joyner JA, Femling JK, Sharma G, Hathaway HJ, Prossnitz ER, Hall PR. Innate Sex Bias of Staphylococcus aureus Skin Infection Is Driven by α-Hemolysin. Journal of Immunology (Baltimore, Md. : 1950). PMID 29222165 DOI: 10.4049/jimmunol.1700810  0.36
2017 Peretti AS, Dominguez D, Grimes MM, Hathaway HJ, Prossnitz ER, Rivera MR, Wandinger-Ness A, Kusewitt DF, Hudson LG. The R-enantiomer of ketorolac delays mammary tumor development in mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) mice. The American Journal of Pathology. PMID 29169987 DOI: 10.1016/j.ajpath.2017.10.018  0.36
2016 Meyer MR, Fredette NC, Daniel C, Sharma G, Amann K, Arterburn JB, Barton M, Prossnitz ER. Obligatory role for GPER in cardiovascular aging and disease. Science Signaling. 9: ra105. PMID 27803283 DOI: 10.1126/scisignal.aag0240  0.44
2016 Wagener BM, Marjon NA, Prossnitz ER. Regulation of N-Formyl Peptide Receptor Signaling and Trafficking by Arrestin-Src Kinase Interaction. Plos One. 11: e0147442. PMID 26788723 DOI: 10.1371/journal.pone.0147442  0.44
2015 Meyer MR, Fredette NC, Howard TA, Hu C, Ramesh C, Daniel C, Amann K, Arterburn JB, Barton M, Prossnitz ER. Erratum: G Protein-coupled Estrogen Receptor Protects from Atherosclerosis. Scientific Reports. 5: 13510. PMID 26373621 DOI: 10.1038/srep13510  0.44
2015 Meyer MR, Fredette NC, Barton M, Prossnitz ER. G protein-coupled estrogen receptor inhibits vascular prostanoid production and activity. The Journal of Endocrinology. PMID 26303299 DOI: 10.1530/JOE-15-0257  0.48
2015 Meyer MR, Fredette NC, Barton M, Prossnitz ER. Prostanoid-mediated contractions of the carotid artery become Nox2-independent with aging. Age (Dordrecht, Netherlands). 37: 9806. PMID 26228838 DOI: 10.1007/s11357-015-9806-9  0.48
2015 Prossnitz ER, Hathaway HJ. What have we learned about GPER function in physiology and disease from knockout mice? The Journal of Steroid Biochemistry and Molecular Biology. 153: 114-26. PMID 26189910 DOI: 10.1016/j.jsbmb.2015.06.014  0.36
2015 Prossnitz ER, Arterburn JB. International Union of Basic and Clinical Pharmacology. XCVII. G Protein-Coupled Estrogen Receptor and Its Pharmacologic Modulators. Pharmacological Reviews. 67: 505-40. PMID 26023144 DOI: 10.1124/pr.114.009712  0.48
2015 Barton M, Prossnitz ER. Emerging roles of GPER in diabetes and atherosclerosis. Trends in Endocrinology and Metabolism: Tem. 26: 185-92. PMID 25767029 DOI: 10.1016/j.tem.2015.02.003  0.48
2014 Meyer MR, Fredette NC, Howard TA, Hu C, Ramesh C, Daniel C, Amann K, Arterburn JB, Barton M, Prossnitz ER. G protein-coupled estrogen receptor protects from atherosclerosis. Scientific Reports. 4: 7564. PMID 25532911 DOI: 10.1038/srep07564  0.44
2014 Nayak TK, Ramesh C, Hathaway HJ, Norenberg JP, Arterburn JB, Prossnitz ER. GPER-targeted, 99mTc-labeled, nonsteroidal ligands demonstrate selective tumor imaging and in vivo estrogen binding. Molecular Cancer Research : McR. 12: 1635-43. PMID 25030373 DOI: 10.1158/1541-7786.MCR-14-0289  0.48
2014 Marjon NA, Hu C, Hathaway HJ, Prossnitz ER. G protein-coupled estrogen receptor regulates mammary tumorigenesis and metastasis. Molecular Cancer Research : McR. 12: 1644-54. PMID 25030371 DOI: 10.1158/1541-7786.MCR-14-0128-T  0.44
2014 Scaling AL, Prossnitz ER, Hathaway HJ. GPER mediates estrogen-induced signaling and proliferation in human breast epithelial cells and normal and malignant breast. Hormones & Cancer. 5: 146-60. PMID 24718936 DOI: 10.1007/s12672-014-0174-1  0.36
2014 Dai D, Bradford AP, Prossnitz ER. Endometrial cancer: molecular and cellular basis of tumor development, novel biomarkers and therapeutic agents, and innovative research approaches. Obstetrics and Gynecology International. 2014: 710405. PMID 24550988 DOI: 10.1155/2014/710405  0.36
2014 Lu J, Hathaway HJ, Royce ME, Prossnitz ER, Miao Y. Introduction of D-phenylalanine enhanced the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorganic & Medicinal Chemistry Letters. 24: 725-30. PMID 24418777 DOI: 10.1016/j.bmcl.2013.12.120  0.48
2013 Petrie WK, Dennis MK, Hu C, Dai D, Arterburn JB, Smith HO, Hathaway HJ, Prossnitz ER. G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth. Obstetrics and Gynecology International. 2013: 472720. PMID 24379833 DOI: 10.1155/2013/472720  0.44
2013 Guo H, Hathaway H, Royce ME, Prossnitz ER, Miao Y. Influences of hydrocarbon linkers on the receptor binding affinities of gonadotropin-releasing hormone peptides. Bioorganic & Medicinal Chemistry Letters. 23: 5484-7. PMID 24018188 DOI: 10.1016/j.bmcl.2013.08.075  0.48
2013 Sharma G, Hu C, Brigman JL, Zhu G, Hathaway HJ, Prossnitz ER. GPER deficiency in male mice results in insulin resistance, dyslipidemia, and a proinflammatory state. Endocrinology. 154: 4136-45. PMID 23970785 DOI: 10.1210/en.2013-1357  0.48
2013 Brunsing RL, Owens KS, Prossnitz ER. The G protein-coupled estrogen receptor (GPER) agonist G-1 expands the regulatory T-cell population under TH17-polarizing conditions. Journal of Immunotherapy (Hagerstown, Md. : 1997). 36: 190-6. PMID 23502766 DOI: 10.1097/CJI.0b013e31828d8e3b  0.72
2012 Burai R, Ramesh C, Nayak TK, Dennis MK, Bryant BK, Prossnitz ER, Arterburn JB. Synthesis and characterization of tricarbonyl-Re/Tc(I) chelate probes targeting the G protein-coupled estrogen receptor GPER/GPR30. Plos One. 7: e46861. PMID 23077529 DOI: 10.1371/journal.pone.0046861  0.48
2012 Meyer MR, Field AS, Kanagy NL, Barton M, Prossnitz ER. GPER regulates endothelin-dependent vascular tone and intracellular calcium. Life Sciences. 91: 623-7. PMID 22326502 DOI: 10.1016/j.lfs.2012.01.007  0.48
2012 Meyer MR, Amann K, Field AS, Hu C, Hathaway HJ, Kanagy NL, Walker MK, Barton M, Prossnitz ER. Deletion of G protein-coupled estrogen receptor increases endothelial vasoconstriction. Hypertension. 59: 507-12. PMID 22203741 DOI: 10.1161/HYPERTENSIONAHA.111.184606  0.48
2011 Yu X, Ma H, Barman SA, Liu AT, Sellers M, Stallone JN, Prossnitz ER, White RE, Han G. Activation of G protein-coupled estrogen receptor induces endothelium-independent relaxation of coronary artery smooth muscle. American Journal of Physiology. Endocrinology and Metabolism. 301: E882-8. PMID 21791623 DOI: 10.1152/ajpendo.00037.2011  0.48
2011 Dennis MK, Field AS, Burai R, Ramesh C, Petrie WK, Bologa CG, Oprea TI, Yamaguchi Y, Hayashi S, Sklar LA, Hathaway HJ, Arterburn JB, Prossnitz ER. Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. The Journal of Steroid Biochemistry and Molecular Biology. 127: 358-66. PMID 21782022 DOI: 10.1016/j.jsbmb.2011.07.002  0.48
2011 Guo H, Lu J, Hathaway H, Royce ME, Prossnitz ER, Miao Y. Synthesis and evaluation of novel gonadotropin-releasing hormone receptor-targeting peptides. Bioconjugate Chemistry. 22: 1682-9. PMID 21749045 DOI: 10.1021/bc200252j  0.48
2011 Brunsing RL, Prossnitz ER. Induction of interleukin-10 in the T helper type 17 effector population by the G protein coupled estrogen receptor (GPER) agonist G-1. Immunology. 134: 93-106. PMID 21722102 DOI: 10.1111/j.1365-2567.2011.03471.x  0.72
2010 Kuo J, Hamid N, Bondar G, Prossnitz ER, Micevych P. Membrane estrogen receptors stimulate intracellular calcium release and progesterone synthesis in hypothalamic astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 12950-7. PMID 20881113 DOI: 10.1523/JNEUROSCI.1158-10.2010  0.48
2010 Huang GS, Gunter MJ, Arend RC, Li M, Arias-Pulido H, Prossnitz ER, Goldberg GL, Smith HO. Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. American Journal of Obstetrics and Gynecology. 203: 242.e1-5. PMID 20605134 DOI: 10.1016/j.ajog.2010.04.046  0.48
2010 Nayak TK, Dennis MK, Ramesh C, Burai R, Atcher RW, Sklar LA, Norenberg JP, Hathaway HJ, Arterburn JB, Prossnitz ER. Influence of charge on cell permeability and tumor imaging of GPR30-targeted 111in-labeled nonsteroidal imaging agents. Acs Chemical Biology. 5: 681-90. PMID 20486699 DOI: 10.1021/cb1000636  0.48
2010 Huang GS, Brouwer-Visser J, Ramirez MJ, Kim CH, Hebert TM, Lin J, Arias-Pulido H, Qualls CR, Prossnitz ER, Goldberg GL, Smith HO, Horwitz SB. Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 2999-3010. PMID 20404007 DOI: 10.1158/1078-0432.CCR-09-3233  0.48
2010 Burai R, Ramesh C, Shorty M, Curpan R, Bologa C, Sklar LA, Oprea T, Prossnitz ER, Arterburn JB. Highly efficient synthesis and characterization of the GPR30-selective agonist G-1 and related tetrahydroquinoline analogs. Organic & Biomolecular Chemistry. 8: 2252-9. PMID 20401403 DOI: 10.1039/c001307b  0.48
2010 Barton M, Meyer MR, Bolton JL, Prossnitz ER. Lung cancer and hormone replacement therapy. Lancet (London, England). 375: 117-8; author reply . PMID 20109881 DOI: 10.1016/S0140-6736(10)60041-4  0.48
2010 Ariazi EA, Brailoiu E, Yerrum S, Shupp HA, Slifker MJ, Cunliffe HE, Black MA, Donato AL, Arterburn JB, Oprea TI, Prossnitz ER, Dun NJ, Jordan VC. The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells. Cancer Research. 70: 1184-94. PMID 20086172 DOI: 10.1158/0008-5472.CAN-09-3068  0.48
2010 Ramesh C, Nayak TK, Burai R, Dennis MK, Hathaway HJ, Sklar LA, Prossnitz ER, Arterburn JB. Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30. Journal of Medicinal Chemistry. 53: 1004-14. PMID 20041667 DOI: 10.1021/jm9011802  0.48
2010 Arias-Pulido H, Royce M, Gong Y, Joste N, Lomo L, Lee SJ, Chaher N, Verschraegen C, Lara J, Prossnitz ER, Cristofanilli M. GPR30 and estrogen receptor expression: new insights into hormone dependence of inflammatory breast cancer. Breast Cancer Research and Treatment. 123: 51-8. PMID 19902352 DOI: 10.1007/s10549-009-0631-7  0.48
2009 Guo H, Yang J, Gallazzi F, Prossnitz ER, Sklar LA, Miao Y. Effect of DOTA position on melanoma targeting and pharmacokinetic properties of 111In-labeled lactam bridge-cyclized alpha-melanocyte stimulating hormone peptide. Bioconjugate Chemistry. 20: 2162-8. PMID 19817405 DOI: 10.1021/bc9003475  0.56
2009 Arterburn JB, Oprea TI, Prossnitz ER, Edwards BS, Sklar LA. Discovery of selective probes and antagonists for G-protein-coupled receptors FPR/FPRL1 and GPR30. Current Topics in Medicinal Chemistry. 9: 1227-36. PMID 19807662 DOI: 10.2174/156802609789753608  0.48
2009 Blasko E, Haskell CA, Leung S, Gualtieri G, Halks-Miller M, Mahmoudi M, Dennis MK, Prossnitz ER, Karpus WJ, Horuk R. Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. Journal of Neuroimmunology. 214: 67-77. PMID 19664827 DOI: 10.1016/j.jneuroim.2009.06.023  0.48
2009 Wagener BM, Marjon NA, Revankar CM, Prossnitz ER. Adaptor protein-2 interaction with arrestin regulates GPCR recycling and apoptosis. Traffic (Copenhagen, Denmark). 10: 1286-300. PMID 19602204 DOI: 10.1111/j.1600-0854.2009.00957.x  0.44
2009 Arias-Pulido H, Smith HO, Joste NE, Bocklage T, Qualls CR, Chavez A, Prossnitz ER, Verschraegen CF. Estrogen and progesterone receptor status and outcome in epithelial ovarian cancers and low malignant potential tumors. Gynecologic Oncology. 114: 480-5. PMID 19560192 DOI: 10.1016/j.ygyno.2009.05.045  0.48
2009 Smith HO, Arias-Pulido H, Kuo DY, Howard T, Qualls CR, Lee SJ, Verschraegen CF, Hathaway HJ, Joste NE, Prossnitz ER. GPR30 predicts poor survival for ovarian cancer. Gynecologic Oncology. 114: 465-71. PMID 19501895 DOI: 10.1016/j.ygyno.2009.05.015  0.48
2009 Haynes MK, Strouse JJ, Waller A, Leitao A, Curpan RF, Bologa C, Oprea TI, Prossnitz ER, Edwards BS, Sklar LA, Thompson TA. Detection of intracellular granularity induction in prostate cancer cell lines by small molecules using the HyperCyt high-throughput flow cytometry system. Journal of Biomolecular Screening. 14: 596-609. PMID 19470718 DOI: 10.1177/1087057109335671  0.48
2009 Dennis MK, Burai R, Ramesh C, Petrie WK, Alcon SN, Nayak TK, Bologa CG, Leitao A, Brailoiu E, Deliu E, Dun NJ, Sklar LA, Hathaway HJ, Arterburn JB, Oprea TI, ... Prossnitz ER, et al. In vivo effects of a GPR30 antagonist. Nature Chemical Biology. 5: 421-7. PMID 19430488 DOI: 10.1038/nchembio.168  0.48
2009 Hazell GG, Yao ST, Roper JA, Prossnitz ER, O'Carroll AM, Lolait SJ. Localisation of GPR30, a novel G protein-coupled oestrogen receptor, suggests multiple functions in rodent brain and peripheral tissues. The Journal of Endocrinology. 202: 223-36. PMID 19420011 DOI: 10.1677/JOE-09-0066  0.48
2009 Edwards BS, Young SM, Ivnitsky-Steele I, Ye RD, Prossnitz ER, Sklar LA. High-content screening: flow cytometry analysis. Methods in Molecular Biology (Clifton, N.J.). 486: 151-65. PMID 19347622 DOI: 10.1007/978-1-60327-545-3_11  0.72
2009 Haas E, Bhattacharya I, Brailoiu E, Damjanović M, Brailoiu GC, Gao X, Mueller-Guerre L, Marjon NA, Gut A, Minotti R, Meyer MR, Amann K, Ammann E, Perez-Dominguez A, Genoni M, ... ... Prossnitz ER, et al. Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity. Circulation Research. 104: 288-91. PMID 19179659 DOI: 10.1161/CIRCRESAHA.108.190892  0.48
2009 Dun SL, Brailoiu GC, Gao X, Brailoiu E, Arterburn JB, Prossnitz ER, Oprea TI, Dun NJ. Expression of estrogen receptor GPR30 in the rat spinal cord and in autonomic and sensory ganglia. Journal of Neuroscience Research. 87: 1610-9. PMID 19125412 DOI: 10.1002/jnr.21980  0.48
2009 Strouse JJ, Young SM, Mitchell HD, Ye RD, Prossnitz ER, Sklar LA, Edwards BS. A novel fluorescent cross-reactive formylpeptide receptor/formylpeptide receptor-like 1 hexapeptide ligand. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 75: 264-70. PMID 19006074 DOI: 10.1002/cyto.a.20670  0.48
2009 Young SM, Bologa CM, Fara D, Bryant BK, Strouse JJ, Arterburn JB, Ye RD, Oprea TI, Prossnitz ER, Sklar LA, Edwards BS. Duplex high-throughput flow cytometry screen identifies two novel formylpeptide receptor family probes. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 75: 253-63. PMID 18785269 DOI: 10.1002/cyto.a.20645  0.48
2008 Nayak TK, Atcher RW, Prossnitz ER, Norenberg JP. Enhancement of somatostatin-receptor-targeted (177)Lu-[DOTA(0)-Tyr(3)]-octreotide therapy by gemcitabine pretreatment-mediated receptor uptake, up-regulation and cell cycle modulation. Nuclear Medicine and Biology. 35: 673-8. PMID 18678352 DOI: 10.1016/j.nucmedbio.2008.05.003  0.48
2008 Nayak TK, Hathaway HJ, Ramesh C, Arterburn JB, Dai D, Sklar LA, Norenberg JP, Prossnitz ER. Preclinical development of a neutral, estrogen receptor-targeted, tridentate 99mTc(I)-estradiol-pyridin-2-yl hydrazine derivative for imaging of breast and endometrial cancers. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 49: 978-86. PMID 18483091 DOI: 10.2967/jnumed.107.048546  0.48
2008 Prossnitz ER, Oprea TI, Sklar LA, Arterburn JB. The ins and outs of GPR30: a transmembrane estrogen receptor. The Journal of Steroid Biochemistry and Molecular Biology. 109: 350-3. PMID 18406603 DOI: 10.1016/j.jsbmb.2008.03.006  0.48
2008 Dennis MK, Bowles HJ, MacKenzie DA, Burchiel SW, Edwards BS, Sklar LA, Prossnitz ER, Thompson TA. A multifunctional androgen receptor screening assay using the high-throughput Hypercyt flow cytometry system. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 73: 390-9. PMID 18340645 DOI: 10.1002/cyto.a.20552  0.72
2008 Prossnitz ER, Arterburn JB, Smith HO, Oprea TI, Sklar LA, Hathaway HJ. Estrogen signaling through the transmembrane G protein-coupled receptor GPR30. Annual Review of Physiology. 70: 165-90. PMID 18271749 DOI: 10.1146/annurev.physiol.70.113006.100518  0.48
2008 Prossnitz ER, Sklar LA, Oprea TI, Arterburn JB. GPR30: a novel therapeutic target in estrogen-related disease. Trends in Pharmacological Sciences. 29: 116-23. PMID 18262661 DOI: 10.1016/j.tips.2008.01.001  0.48
2007 Edwards BS, Young SM, Saunders MJ, Bologa C, Oprea TI, Ye RD, Prossnitz ER, Graves SW, Sklar LA. High-throughput flow cytometry for drug discovery. Expert Opinion On Drug Discovery. 2: 685-96. PMID 23488958 DOI: 10.1517/17460441.2.5.685  0.48
2007 Wu Y, Buranda T, Simons PC, Lopez GP, McIntire WE, Garrison JC, Prossnitz ER, Sklar LA. Rapid-mix flow cytometry measurements of subsecond regulation of G protein-coupled receptor ternary complex dynamics by guanine nucleotides. Analytical Biochemistry. 371: 10-20. PMID 17904091 DOI: 10.1016/j.ab.2007.08.011  0.8
2007 Buranda T, Waller A, Wu Y, Simons PC, Biggs S, Prossnitz ER, Sklar LA. Some mechanistic insights into GPCR activation from detergent-solubilized ternary complexes on beads. Advances in Protein Chemistry. 74: 95-135. PMID 17854656 DOI: 10.1016/S0065-3233(07)74003-2  0.8
2007 Revankar CM, Mitchell HD, Field AS, Burai R, Corona C, Ramesh C, Sklar LA, Arterburn JB, Prossnitz ER. Synthetic estrogen derivatives demonstrate the functionality of intracellular GPR30. Acs Chemical Biology. 2: 536-44. PMID 17655271 DOI: 10.1021/cb700072n  0.48
2007 Brailoiu E, Dun SL, Brailoiu GC, Mizuo K, Sklar LA, Oprea TI, Prossnitz ER, Dun NJ. Distribution and characterization of estrogen receptor G protein-coupled receptor 30 in the rat central nervous system. The Journal of Endocrinology. 193: 311-21. PMID 17470522 DOI: 10.1677/JOE-07-0017  0.48
2007 Smith HO, Leslie KK, Singh M, Qualls CR, Revankar CM, Joste NE, Prossnitz ER. GPR30: a novel indicator of poor survival for endometrial carcinoma. American Journal of Obstetrics and Gynecology. 196: 386.e1-9; discussion. PMID 17403429 DOI: 10.1016/j.ajog.2007.01.004  0.48
2007 Albanito L, Madeo A, Lappano R, Vivacqua A, Rago V, Carpino A, Oprea TI, Prossnitz ER, Musti AM, Andò S, Maggiolini M. G protein-coupled receptor 30 (GPR30) mediates gene expression changes and growth response to 17beta-estradiol and selective GPR30 ligand G-1 in ovarian cancer cells. Cancer Research. 67: 1859-66. PMID 17308128 DOI: 10.1158/0008-5472.CAN-06-2909  0.36
2007 Nayak TK, Norenberg JP, Anderson TL, Prossnitz ER, Stabin MG, Atcher RW. Somatostatin-receptor-targeted alpha-emitting 213Bi is therapeutically more effective than beta(-)-emitting 177Lu in human pancreatic adenocarcinoma cells. Nuclear Medicine and Biology. 34: 185-93. PMID 17307126 DOI: 10.1016/j.nucmedbio.2006.11.006  0.48
2007 Xue M, Hsieh G, Raymond-Stintz MA, Pfeiffer J, Roberts D, Steinberg SL, Oliver JM, Prossnitz ER, Lidke DS, Wilson BS. Activated N-formyl peptide receptor and high-affinity IgE receptor occupy common domains for signaling and internalization. Molecular Biology of the Cell. 18: 1410-20. PMID 17267694 DOI: 10.1091/mbc.E05-11-1073  0.48
2007 Prossnitz ER, Arterburn JB, Sklar LA. GPR30: A G protein-coupled receptor for estrogen. Molecular and Cellular Endocrinology. 265: 138-42. PMID 17222505 DOI: 10.1016/j.mce.2006.12.010  0.48
2006 Prossnitz ER, Arterburn JB, Edwards BS, Sklar LA, Oprea TI. Steroid-binding G-protein-coupled receptors: new drug discovery targets for old ligands. Expert Opinion On Drug Discovery. 1: 137-50. PMID 23495797 DOI: 10.1517/17460441.1.2.137  0.48
2006 Prossnitz ER, Sklar LA. Modulation of GPCR conformations by ligands, G-proteins, and arrestins. Ernst Schering Foundation Symposium Proceedings. 211-28. PMID 17703584  0.56
2006 Edwards BS, Young SM, Oprea TI, Bologa CG, Prossnitz ER, Sklar LA. Biomolecular screening of formylpeptide receptor ligands with a sensitive, quantitative, high-throughput flow cytometry platform. Nature Protocols. 1: 59-66. PMID 17406212 DOI: 10.1038/nprot.2006.9  0.72
2006 Ramesh C, Bryant B, Nayak T, Revankar CM, Anderson T, Carlson KE, Katzenellenbogen JA, Sklar LA, Norenberg JP, Prossnitz ER, Arterburn JB. Linkage effects on binding affinity and activation of GPR30 and estrogen receptors ERalpha/beta with tridentate pyridin-2-yl hydrazine tricarbonyl-Re/(99m)Tc(I) chelates. Journal of the American Chemical Society. 128: 14476-7. PMID 17090028 DOI: 10.1021/ja066360p  0.48
2006 Potter RM, Maestas DC, Cimino DF, Prossnitz ER. Regulation of N-formyl peptide receptor signaling and trafficking by individual carboxyl-terminal serine and threonine residues. Journal of Immunology (Baltimore, Md. : 1950). 176: 5418-25. PMID 16622009  0.88
2006 Tessema M, Simons PC, Cimino DF, Sanchez L, Waller A, Posner RG, Wandinger-Ness A, Prossnitz ER, Sklar LA. Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 69: 326-34. PMID 16604533 DOI: 10.1002/cyto.a.20259  0.48
2006 Bologa CG, Revankar CM, Young SM, Edwards BS, Arterburn JB, Kiselyov AS, Parker MA, Tkachenko SE, Savchuck NP, Sklar LA, Oprea TI, Prossnitz ER. Virtual and biomolecular screening converge on a selective agonist for GPR30. Nature Chemical Biology. 2: 207-12. PMID 16520733 DOI: 10.1038/nchembio775  0.48
2006 Makino A, Prossnitz ER, Bünemann M, Wang JM, Yao W, Schmid-Schönbein GW. G protein-coupled receptors serve as mechanosensors for fluid shear stress in neutrophils. American Journal of Physiology. Cell Physiology. 290: C1633-9. PMID 16436471 DOI: 10.1152/ajpcell.00576.2005  0.48
2005 Edwards BS, Bologa C, Young SM, Balakin KV, Prossnitz ER, Savchuck NP, Sklar LA, Oprea TI. Integration of virtual screening with high-throughput flow cytometry to identify novel small molecule formylpeptide receptor antagonists. Molecular Pharmacology. 68: 1301-10. PMID 16118363 DOI: 10.1124/mol.105.014068  0.72
2005 Oprea TI, Bologa CG, Edwards BS, Prossnitz ER, Sklar LA. Post-high-throughput screening analysis: an empirical compound prioritization scheme. Journal of Biomolecular Screening. 10: 419-26. PMID 16093551 DOI: 10.1177/1087057104272660  0.72
2005 Carter JM, Gurevich VV, Prossnitz ER, Engen JR. Conformational differences between arrestin2 and pre-activated mutants as revealed by hydrogen exchange mass spectrometry. Journal of Molecular Biology. 351: 865-78. PMID 16045931 DOI: 10.1016/j.jmb.2005.06.048  0.48
2005 Young SM, Bologa C, Prossnitz ER, Oprea TI, Sklar LA, Edwards BS. High-throughput screening with HyperCyt flow cytometry to detect small molecule formylpeptide receptor ligands. Journal of Biomolecular Screening. 10: 374-82. PMID 15964939 DOI: 10.1177/1087057105274532  0.72
2005 Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science (New York, N.Y.). 307: 1625-30. PMID 15705806 DOI: 10.1126/science.1106943  0.48
2005 Key TA, Vines CM, Wagener BM, Gurevich VV, Sklar LA, Prossnitz ER. Inhibition of chemoattractant N-formyl peptide receptor trafficking by active arrestins. Traffic (Copenhagen, Denmark). 6: 87-99. PMID 15634210 DOI: 10.1111/j.1600-0854.2004.00248.x  0.56
2004 Waller A, Simons PC, Biggs SM, Edwards BS, Prossnitz ER, Sklar LA. Techniques: GPCR assembly, pharmacology and screening by flow cytometry. Trends in Pharmacological Sciences. 25: 663-9. PMID 15530645 DOI: 10.1016/j.tips.2004.10.009  0.72
2004 Xue M, Vines CM, Buranda T, Cimino DF, Bennett TA, Prossnitz ER. N-formyl peptide receptors cluster in an active raft-associated state prior to phosphorylation. The Journal of Biological Chemistry. 279: 45175-84. PMID 15302864 DOI: 10.1074/jbc.M407053200  0.48
2004 Edwards BS, Oprea T, Prossnitz ER, Sklar LA. Flow cytometry for high-throughput, high-content screening. Current Opinion in Chemical Biology. 8: 392-8. PMID 15288249 DOI: 10.1016/j.cbpa.2004.06.007  0.72
2004 Vines CM, Prossnitz ER. Mechanisms of G protein-coupled receptor-mediated degranulation. Fems Microbiology Letters. 236: 1-6. PMID 15212783 DOI: 10.1016/j.femsle.2004.05.017  0.44
2004 Chigaev A, Zwartz GJ, Buranda T, Edwards BS, Prossnitz ER, Sklar LA. Conformational regulation of alpha 4 beta 1-integrin affinity by reducing agents. "Inside-out" signaling is independent of and additive to reduction-regulated integrin activation. The Journal of Biological Chemistry. 279: 32435-43. PMID 15166232 DOI: 10.1074/jbc.M404387200  0.8
2004 Revankar CM, Vines CM, Cimino DF, Prossnitz ER. Arrestins block G protein-coupled receptor-mediated apoptosis. The Journal of Biological Chemistry. 279: 24578-84. PMID 15051714 DOI: 10.1074/jbc.M402121200  0.8
2004 Young SM, Curry MS, Ransom JT, Ballesteros JA, Prossnitz ER, Sklar LA, Edwards BS. High-throughput microfluidic mixing and multiparametric cell sorting for bioactive compound screening. Journal of Biomolecular Screening. 9: 103-11. PMID 15006133 DOI: 10.1177/1087057103262335  0.8
2004 Simons PC, Biggs SM, Waller A, Foutz T, Cimino DF, Guo Q, Neubig RR, Tang WJ, Prossnitz ER, Sklar LA. Real-time analysis of ternary complex on particles: direct evidence for partial agonism at the agonist-receptor-G protein complex assembly step of signal transduction. The Journal of Biological Chemistry. 279: 13514-21. PMID 14726530 DOI: 10.1074/jbc.M310306200  0.48
2003 Chigaev A, Buranda T, Dwyer DC, Prossnitz ER, Sklar LA. FRET detection of cellular alpha4-integrin conformational activation. Biophysical Journal. 85: 3951-62. PMID 14645084 DOI: 10.1016/S0006-3495(03)74809-7  0.8
2003 Vines CM, Revankar CM, Maestas DC, LaRusch LL, Cimino DF, Kohout TA, Lefkowitz RJ, Prossnitz ER. N-formyl peptide receptors internalize but do not recycle in the absence of arrestins. The Journal of Biological Chemistry. 278: 41581-4. PMID 12947104 DOI: 10.1074/jbc.C300291200  0.48
2003 Chigaev A, Zwartz G, Graves SW, Dwyer DC, Tsuji H, Foutz TD, Edwards BS, Prossnitz ER, Larson RS, Sklar LA. Alpha4beta1 integrin affinity changes govern cell adhesion. The Journal of Biological Chemistry. 278: 38174-82. PMID 12844491 DOI: 10.1074/jbc.M210472200  0.48
2003 Shi M, Bennett TA, Cimino DF, Maestas DC, Foutz TD, Gurevich VV, Sklar LA, Prossnitz ER. Functional capabilities of an N-formyl peptide receptor-G(alpha)(i)(2) fusion protein: assemblies with G proteins and arrestins. Biochemistry. 42: 7283-93. PMID 12809484 DOI: 10.1021/bi0341657  0.48
2003 Key TA, Foutz TD, Gurevich VV, Sklar LA, Prossnitz ER. N-formyl peptide receptor phosphorylation domains differentially regulate arrestin and agonist affinity. The Journal of Biological Chemistry. 278: 4041-7. PMID 12424254 DOI: 10.1074/jbc.M204687200  0.56
2002 Vines CM, Xue M, Maestas DC, Cimino DF, Prossnitz ER. Regulation of N-formyl peptide-mediated degranulation by receptor phosphorylation. Journal of Immunology (Baltimore, Md. : 1950). 169: 6760-6. PMID 12471107  0.8
2002 Sklar LA, Edwards BS, Graves SW, Nolan JP, Prossnitz ER. Flow cytometric analysis of ligand-receptor interactions and molecular assemblies. Annual Review of Biophysics and Biomolecular Structure. 31: 97-119. PMID 11988464 DOI: 10.1146/annurev.biophys.31.082901.134406  0.48
2002 Potter RM, Key TA, Gurevich VV, Sklar LA, Prossnitz ER. Arrestin variants display differential binding characteristics for the phosphorylated N-formyl peptide receptor carboxyl terminus. The Journal of Biological Chemistry. 277: 8970-8. PMID 11777932 DOI: 10.1074/jbc.M111086200  0.88
2002 Graham TE, Prossnitz ER, Dorin RI. Dexras1/AGS-1 inhibits signal transduction from the Gi-coupled formyl peptide receptor to Erk-1/2 MAP kinases. The Journal of Biological Chemistry. 277: 10876-82. PMID 11751935 DOI: 10.1074/jbc.M110397200  0.48
2001 Gilbert TL, Bennett TA, Maestas DC, Cimino DF, Prossnitz ER. Internalization of the human N-formyl peptide and C5a chemoattractant receptors occurs via clathrin-independent mechanisms. Biochemistry. 40: 3467-75. PMID 11297412 DOI: 10.1021/bi001320y  0.48
1999 Maestes DC, Potter RM, Prossnitz ER. Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. The Journal of Biological Chemistry. 274: 29791-5. PMID 10514456  0.88
1999 Gilbert TL, Prossnitz ER, Sklar LA. The uncoupled state of the human formyl peptide receptor. Journal of Receptor and Signal Transduction Research. 19: 327-40. PMID 10071768 DOI: 10.3109/10799899909036655  0.48
1999 Prossnitz ER, Gilbert TL, Chiang S, Campbell JJ, Qin S, Newman W, Sklar LA, Ye RD. Multiple activation steps of the N-formyl peptide receptor. Biochemistry. 38: 2240-7. PMID 10029516 DOI: 10.1021/bi982274t  0.48
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