| Year |
Citation |
Score |
| 2019 |
Boudreau MD, Sohn KH, Rhee SH, Lee SW, Hunt JD, Hwang DH. Editor's Note: Suppression of Tumor Cell Growth Both in Nude Mice and in Culture by n-3 Polyunsaturated Fatty Acids: Mediation through Cyclooxygenase-Independent Pathways. Cancer Research. 79: 5125. PMID 31575633 DOI: 10.1158/0008-5472.CAN-19-2362 |
0.702 |
|
| 2016 |
Ono-Moore KD, Snodgrass RG, Huang S, Singh S, Freytag TL, Burnett DJ, Bonnel EL, Woodhouse LR, Zunino SJ, Peerson JM, Lee JY, Rutledge JC, Hwang DH. Postprandial Inflammatory Responses and Free Fatty Acids in Plasma of Adults Who Consumed a Moderately High-Fat Breakfast with and without Blueberry Powder in a Randomized Placebo-Controlled Trial. The Journal of Nutrition. PMID 27306892 DOI: 10.3945/jn.115.223909 |
0.411 |
|
| 2016 |
Hwang DH, Kim JA, Lee JY. Mechanisms for the activation of Toll-like receptor 2/4 by saturated fatty acids and inhibition by docosahexaenoic acid. European Journal of Pharmacology. PMID 27085899 DOI: 10.1016/j.ejphar.2016.04.024 |
0.37 |
|
| 2014 |
Rutkowsky JM, Knotts TA, Ono-Moore KD, McCoin CS, Huang S, Schneider D, Singh S, Adams SH, Hwang DH. Acylcarnitines activate proinflammatory signaling pathways. American Journal of Physiology. Endocrinology and Metabolism. 306: E1378-87. PMID 24760988 DOI: 10.1152/ajpendo.00656.2013 |
0.343 |
|
| 2014 |
Jeong E, Koo JE, Yeon SH, Kwak MK, Hwang DH, Lee JY. PPARδ deficiency disrupts hypoxia-mediated tumorigenic potential of colon cancer cells. Molecular Carcinogenesis. 53: 926-37. PMID 24610641 DOI: 10.1002/mc.22144 |
0.308 |
|
| 2013 |
Snodgrass RG, Huang S, Choi IW, Rutledge JC, Hwang DH. Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids. Journal of Immunology (Baltimore, Md. : 1950). 191: 4337-47. PMID 24043885 DOI: 10.4049/jimmunol.1300298 |
0.411 |
|
| 2012 |
Huang S, Rutkowsky JM, Snodgrass RG, Ono-Moore KD, Schneider DA, Newman JW, Adams SH, Hwang DH. Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways. Journal of Lipid Research. 53: 2002-13. PMID 22766885 DOI: 10.1194/Jlr.D029546 |
0.44 |
|
| 2012 |
Dawson K, Zhao L, Adkins Y, Vemuri M, Rodriguez RL, Gregg JP, Kelley DS, Hwang DH. Modulation of blood cell gene expression by DHA supplementation in hypertriglyceridemic men. The Journal of Nutritional Biochemistry. 23: 616-21. PMID 21775114 DOI: 10.1016/J.Jnutbio.2011.03.004 |
0.35 |
|
| 2010 |
Lee JY, Zhao L, Hwang DH. Modulation of pattern recognition receptor-mediated inflammation and risk of chronic diseases by dietary fatty acids. Nutrition Reviews. 68: 38-61. PMID 20041999 DOI: 10.1111/j.1753-4887.2009.00259.x |
0.315 |
|
| 2010 |
Youn HS, Kim YS, Park ZY, Kim SY, Choi NY, Joung SM, Seo JA, Lim KM, Kwak MK, Hwang DH, Lee JY. Sulforaphane suppresses oligomerization of TLR4 in a thiol-dependent manner. Journal of Immunology (Baltimore, Md. : 1950). 184: 411-9. PMID 19949083 DOI: 10.4049/jimmunol.0803988 |
0.398 |
|
| 2009 |
Wong SW, Kwon MJ, Choi AM, Kim HP, Nakahira K, Hwang DH. Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species-dependent manner. The Journal of Biological Chemistry. 284: 27384-92. PMID 19648648 DOI: 10.1074/Jbc.M109.044065 |
0.519 |
|
| 2009 |
Lee JK, Kim SY, Kim YS, Lee WH, Hwang DH, Lee JY. Suppression of the TRIF-dependent signaling pathway of Toll-like receptors by luteolin. Biochemical Pharmacology. 77: 1391-400. PMID 19426678 DOI: 10.1016/j.bcp.2009.01.009 |
0.408 |
|
| 2008 |
Dasu MR, Devaraj S, Zhao L, Hwang DH, Jialal I. High glucose induces toll-like receptor expression in human monocytes: mechanism of activation. Diabetes. 57: 3090-8. PMID 18650365 DOI: 10.2337/db08-0564 |
0.32 |
|
| 2008 |
Lee JS, Lee JY, Lee MY, Hwang DH, Youn HS. Acrolein with an alpha, beta-unsaturated carbonyl group inhibits LPS-induced homodimerization of toll-like receptor 4. Molecules and Cells. 25: 253-7. PMID 18414004 |
0.391 |
|
| 2008 |
Huang S, Zhao L, Kim K, Lee DS, Hwang DH. Inhibition of Nod2 signaling and target gene expression by curcumin. Molecular Pharmacology. 74: 274-81. PMID 18413660 DOI: 10.1124/mol.108.046169 |
0.369 |
|
| 2008 |
Youn HS, Lim HJ, Lee HJ, Hwang D, Yang M, Jeon R, Ryu JH. Garlic (Allium sativum) extract inhibits lipopolysaccharide-induced Toll-like receptor 4 dimerization. Bioscience, Biotechnology, and Biochemistry. 72: 368-75. PMID 18256479 DOI: 10.1271/bbb.70434 |
0.422 |
|
| 2008 |
Zhao L, Lee JY, Hwang DH. The phosphatidylinositol 3-kinase/Akt pathway negatively regulates Nod2-mediated NF-kappaB pathway. Biochemical Pharmacology. 75: 1515-25. PMID 18243161 DOI: 10.1016/j.bcp.2007.12.014 |
0.303 |
|
| 2008 |
Youn HS, Lee JK, Choi YJ, Saitoh SI, Miyake K, Hwang DH, Lee JY. Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization. Biochemical Pharmacology. 75: 494-502. PMID 17920563 DOI: 10.1016/j.bcp.2007.08.033 |
0.43 |
|
| 2007 |
Zhao L, Kwon MJ, Huang S, Lee JY, Fukase K, Inohara N, Hwang DH. Differential modulation of Nods signaling pathways by fatty acids in human colonic epithelial HCT116 cells. The Journal of Biological Chemistry. 282: 11618-28. PMID 17303577 DOI: 10.1074/jbc.M608644200 |
0.46 |
|
| 2006 |
Youn HS, Lee JY, Saitoh SI, Miyake K, Hwang DH. Auranofin, as an anti-rheumatic gold compound, suppresses LPS-induced homodimerization of TLR4. Biochemical and Biophysical Research Communications. 350: 866-71. PMID 17034761 DOI: 10.1016/j.bbrc.2006.09.097 |
0.385 |
|
| 2006 |
Youn HS, Lee JY, Saitoh SI, Miyake K, Kang KW, Choi YJ, Hwang DH. Suppression of MyD88- and TRIF-dependent signaling pathways of Toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea. Biochemical Pharmacology. 72: 850-9. PMID 16890209 DOI: 10.1016/j.bcp.2006.06.021 |
0.429 |
|
| 2006 |
Lee JY, Hwang DH. The modulation of inflammatory gene expression by lipids: mediation through Toll-like receptors. Molecules and Cells. 21: 174-85. PMID 16682810 |
0.345 |
|
| 2006 |
Youn HS, Saitoh SI, Miyake K, Hwang DH. Inhibition of homodimerization of Toll-like receptor 4 by curcumin. Biochemical Pharmacology. 72: 62-9. PMID 16678799 DOI: 10.1016/j.bcp.2006.03.022 |
0.429 |
|
| 2005 |
Lee JY, Lowell CA, Lemay DG, Youn HS, Rhee SH, Sohn KH, Jang B, Ye J, Chung JH, Hwang DH. The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4. Biochemical Pharmacology. 70: 1231-40. PMID 16140274 DOI: 10.1016/J.Bcp.2005.07.020 |
0.719 |
|
| 2005 |
Youn HS, Lee JY, Fitzgerald KA, Young HA, Akira S, Hwang DH. Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex. Journal of Immunology (Baltimore, Md. : 1950). 175: 3339-46. PMID 16116226 |
0.445 |
|
| 2005 |
Weatherill AR, Lee JY, Zhao L, Lemay DG, Youn HS, Hwang DH. Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4. Journal of Immunology (Baltimore, Md. : 1950). 174: 5390-7. PMID 15843537 |
0.413 |
|
| 2004 |
Gao Z, Zhang X, Zuberi A, Hwang D, Quon MJ, Lefevre M, Ye J. Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes. Molecular Endocrinology (Baltimore, Md.). 18: 2024-34. PMID 15143153 DOI: 10.1210/Me.2003-0383 |
0.364 |
|
| 2004 |
Lee JY, Zhao L, Youn HS, Weatherill AR, Tapping R, Feng L, Lee WH, Fitzgerald KA, Hwang DH. Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1. The Journal of Biological Chemistry. 279: 16971-9. PMID 14966134 DOI: 10.1074/Jbc.M312990200 |
0.424 |
|
| 2003 |
Lee JY, Ye J, Gao Z, Youn HS, Lee WH, Zhao L, Sizemore N, Hwang DH. Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. The Journal of Biological Chemistry. 278: 37041-51. PMID 12865424 DOI: 10.1074/jbc.M305213200 |
0.468 |
|
| 2003 |
Lee JY, Plakidas A, Lee WH, Heikkinen A, Chanmugam P, Bray G, Hwang DH. Differential modulation of Toll-like receptors by fatty acids: preferential inhibition by n-3 polyunsaturated fatty acids. Journal of Lipid Research. 44: 479-86. PMID 12562875 DOI: 10.1194/jlr.M200361-JLR200 |
0.502 |
|
| 2002 |
Paik J, Lee JY, Hwang D. Signaling pathways for TNFa-induced COX-2 expression: Mediation through map kinases and NFkB, and inhibition by certain nonsteroidal anti-inflammatory drugs Advances in Experimental Medicine and Biology. 507: 503-508. PMID 12664632 DOI: 10.1007/978-1-4615-0193-0_77 |
0.379 |
|
| 2002 |
Lee JY, Hwang DH. Docosahexaenoic acid suppresses the activity of peroxisome proliferator-activated receptors in a colon tumor cell line. Biochemical and Biophysical Research Communications. 298: 667-74. PMID 12419306 |
0.376 |
|
| 2002 |
Bray GA, Lovejoy JC, Smith SR, DeLany JP, Lefevre M, Hwang D, Ryan DH, York DA. The influence of different fats and fatty acids on obesity, insulin resistance and inflammation. The Journal of Nutrition. 132: 2488-91. PMID 12221198 DOI: 10.1093/Jn/132.9.2488 |
0.318 |
|
| 2002 |
Hwang D. Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived signaling pathways. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 15: 2556-64. PMID 11726530 DOI: 10.1096/Fj.01-0432Com |
0.588 |
|
| 2001 |
Lee JY, Sohn KH, Rhee SH, Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. The Journal of Biological Chemistry. 276: 16683-9. PMID 11278967 DOI: 10.1074/Jbc.M011695200 |
0.728 |
|
| 2001 |
Boudreau MD, Sohn KH, Rhee SH, Lee SW, Hunt JD, Hwang DH. Suppression of tumor cell growth both in nude mice and in culture by n-3 polyunsaturated fatty acids: mediation through cyclooxygenase-independent pathways. Cancer Research. 61: 1386-91. PMID 11245439 |
0.702 |
|
| 2000 |
Rhee SH, Hwang D. Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase. The Journal of Biological Chemistry. 275: 34035-40. PMID 10952994 DOI: 10.1074/Jbc.M007386200 |
0.705 |
|
| 2000 |
Hwang D. Fatty acids and immune responses--a new perspective in searching for clues to mechanism. Annual Review of Nutrition. 20: 431-56. PMID 10940341 DOI: 10.1146/Annurev.Nutr.20.1.431 |
0.457 |
|
| 2000 |
Paik JH, Ju JH, Lee JY, Boudreau MD, Hwang DH. Two opposing effects of non-steroidal anti-inflammatory drugs on the expression of the inducible cyclooxygenase. Mediation through different signaling pathways. The Journal of Biological Chemistry. 275: 28173-9. PMID 10866999 DOI: 10.1074/jbc.M002329200 |
0.447 |
|
| 1999 |
Hwang D, Rhee SH. Receptor-mediated signaling pathways: potential targets of modulation by dietary fatty acids. The American Journal of Clinical Nutrition. 70: 545-56. PMID 10500025 DOI: 10.1093/Ajcn/70.4.545 |
0.663 |
|
| 1999 |
Hwang D, Chanmugam P, Boudreau M, Sohn KH, Stone K, Pryor WA. Activation and inactivation of cyclo-oxygenase in rat alveolar macrophages by aqueous cigarette tar extracts. Free Radical Biology & Medicine. 27: 673-82. PMID 10490288 DOI: 10.1016/S0891-5849(99)00120-3 |
0.697 |
|
| 1998 |
Wu D, Mura C, Beharka AA, Han SN, Paulson KE, Hwang D, Meydani SN. Age-associated increase in PGE2 synthesis and COX activity in murine macrophages is reversed by vitamin E. The American Journal of Physiology. 275: C661-8. PMID 9730949 DOI: 10.1152/Ajpcell.1998.275.3.C661 |
0.346 |
|
| 1997 |
Feng L, Jang BC, Hwang D. Inhibitor of protein tyrosine kinase, radicicol, suppresses the expression of cyclooxygenase and pro-inflammatory cytokines in LPS-stimulated rat alveolar macrophage in part by accelerating degradation of mRNA. Advances in Experimental Medicine and Biology. 407: 281-8. PMID 9321965 DOI: 10.1007/978-1-4899-1813-0_42 |
0.468 |
|
| 1997 |
Hwang D, Jang BC, Yu G, Boudreau M. Expression of mitogen-inducible cyclooxygenase induced by lipopolysaccharide: mediation through both mitogen-activated protein kinase and NF-kappaB signaling pathways in macrophages. Biochemical Pharmacology. 54: 87-96. PMID 9296354 DOI: 10.1016/S0006-2952(97)00154-8 |
0.523 |
|
| 1996 |
Hwang D, Fischer NH, Jang BC, Tak H, Kim JK, Lee W. Inhibition of the expression of inducible cyclooxygenase and proinflammatory cytokines by sesquiterpene lactones in macrophages correlates with the inhibition of MAP kinases. Biochemical and Biophysical Research Communications. 226: 810-8. PMID 8831694 DOI: 10.1006/Bbrc.1996.1433 |
0.424 |
|
| 1993 |
Feng L, Sun W, Xia Y, Tang WW, Chanmugam P, Soyoola E, Wilson CB, Hwang D. Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. Archives of Biochemistry and Biophysics. 307: 361-368. PMID 8274023 DOI: 10.1006/Abbi.1993.1601 |
0.436 |
|
| 1989 |
Hwang D. Essential fatty acids and immune response. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 3: 2052-61. PMID 2501132 DOI: 10.1096/Fasebj.3.9.2501132 |
0.403 |
|
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